研究成果

[雑誌論文] Keratinocyte growth factor enhances post-natal T cell development via improvement in proliferation and function of thymic epithelial cells.

Rossi S, Jeker LT, Ueno T, Kuse S, Keller MP, Zuklys A, Gudkov A, Takahama Y, Krenger W, Blazar BR, Hollander GA. 2007

[雑誌論文] The lymphocyte guard-IANs : regulation of lymphocyte survival by IAN/GIMAP family proteins.

Nitta T, Takahama Y. 2007

[雑誌論文] Chemokines CCL19 and CCL21 promote activation-induced cell death of antigen-responding T cells.

Yasuda T, Kuwabara T, Nakano H, Aritomi K, Onodera T, Lipp M, Takahama Y, Kakiuchi T. 2007

[雑誌論文] Cellular and molecular events during early thymus development.

Hollander GA, Gill J, Zuklys S, Iwanami N, Liu C, Takahama Y. 2006

[雑誌論文] Journey through the thymus : stromal guides for T-cell development and selection.

Takahama Y. 2006

[雑誌論文] CCR7-dependent cortex-medulla migration of positively selected thymocytes is essential for establishing central tolerance.

Kurobe H, Liu C, Ueno T, Saito F, Ohigashi I, Seach N, Arakaki R, Hayashi Y, Kitagawa T, Lipp M, Boyd RL, Takahama Y. 2006

[雑誌論文] Journey through the thymus : stromal guides for T-cell development and selection.

Takahama Y. 2006

[雑誌論文] Thymic involution produced by diesel exhaust particles and their constituents in mice.

Tomita S, Maekawa S, Rahman M, Saito F, Kizu R, Tohi K, Ueno T, Nakase H, Gonzalez FJ, Hayakawa K, Korenaga T, Takahama Y. 2006

[雑誌論文] In vitro systems for the study of T cell development : fetal thymus organ culture and OP9-DL1 cell coculture.

Ramsdell F, Zuniga-Pflucker JC, Takahama Y. 2006

[雑誌論文] Coordination between CCR7-and CCR9-mediated chemokine signals in pre-vascular fetal thymus colonization.

Liu C, Saito F, Liu Z, Lei Y, Uehara S, Love PE, Lipp M, Kondo S, Manley NR, Takahama Y. 2006

[雑誌論文] IAN family critically regulates survival and development of T lymphocytes.

Nitta T, Nasreen M, Seike T, Goji A, Ohigashi I, Miyazaki T, Ohta T, Kanno M, Takahama, Y. 2006

[雑誌論文] Journey through the thymus : stromal guides for T-cell development and selection.

Takahama Y 2006

[雑誌論文] Controlling the thymic microenvironment.

Gray DHD, Ueno T, Chidgey AP, Malin M, Goldberg GL, Takahama Y, Boyd RL. 2005

[雑誌論文] The role of CCL21 in recruitment of T precursor cells to fetal thymi.

Liu C, Ueno T, Kuse S, Saito F, Nitta T, Piali L, Nakano H, Kakiuchi T, Lipp M, Hollander GA, TakahamaY. 2005

[雑誌論文] Development of autoimmunity against transcriptionally unrepressed target antigen in the thymus from Aire-deficient mice.

Kuroda N, Mitani T, Takeda N, Ishimaru N, Arakaki R, Hayashi Y, Bando Y, Izumi K, Takahashi T, Nomura T, Sakaguchi S, Ueno T, Takahama Y, Uchida D, Sun S, Kajiura F, Mouri Y, Han H, Matsushima A, Yamada G, Matsumoto M. 2005

[雑誌論文] Mutations affecting liver development and function in Medaka, Oryzias latipes.

Watanabe T, Asaka S, Kitagawa D, Saito K, Kurashige R, Sasado T, Morinaga C, Suwa H, Niwa K, Henrich T, Hirose Y, Yasuoka A, Yoda H, Deguchi T, Iwanami N, Kunimatsu S, Osakada M, Loosli F, Quiring R, Carl M, Grabher C, Winkler S, Del Bene F, Wittbrodt J, Abe K, Takahama Y, Takahashi K, Katada T, Nishina H, Kondoh H, Furutani-Seiki M. 2004

[雑誌論文] Mutations affecting somite formation in the Medaka (Oryzias latipes).

Elmasri H, Winider C, Liedtke D, Sasado T, Morinaga C, Suwa H, Niwa K, Henrich T, Hirose Y, Yasuoka A, Yoda H, Watanabe T, Deguchi T, Iwanami N, Kunimatsu S, Osakada M, Loosli F, Quiring R, Carl M, Grabher C, Winkler S, Del Bene F, Wittbrodt J, Abe K, Takahama Y, Takahashi K, Katada T, Nishina H, Kondoh H, Furutani-Seiki M. 2004

[雑誌論文] A systematic genome-wide screen for mutations affecting organogenesis in Medaka, Oryzias latipes.

Furutani-Seiki M, Sasado T, Morinaga C, Suwa H, Niwa K, Yoda H, Deguchi T, Hirose Y, Yasuoka A, Henrich T, Watanabe T, Iwanami N, Kitagawa D, Saito K, Asaka S, Osakada M, Kunimatsu S, Momoi A, Elmasri H, Winkler C, Ramialison M, Loosli F, Quiring R, Carl M, Grabher C, Winkler S, Del Bene F, Shinomiya A, Kota Y, Yamanaka T, Okamoto Y, Takahashi K, Todo T, Abe K, Takahama Y, Tanaka M, Mitani H, Katada T, Nishina H, Nakajima N, Wittbrodt J, Kondoh H. 2004

[雑誌論文] Increased frequency of aberrant V(D)J recombination preparation in core RAG-expressing mice.

Talukder SR, Dudley DD, Alt FW, Takahama Y, Akamatsu Y. 2004

[雑誌論文] The development of T lymphocytes in mouse fetal thymus organ culture.

Ueno T, Liu C, Nitta T, Takahama Y. 2004

[雑誌論文] Developmental status of CD4-CD8+ and CD4+CD8-thymocytes with medium expression of CD3.

Sheard MA, Liu C, Takahama Y. 2004

[雑誌論文] NF-kappaB-inducing kinase establishes self-tolerance in a thymic-stroma dependent manner.

Kajiura F, Sun S, Nomura T, Izumi K, Ueno T, Bando Y, Kuroda N, Han H, Li Y, Matsushima A, Takahama Y, Sakaguchi S, Mitani T, Matsumoto M. 2004

[雑誌論文] Mutations affecting thymus organogenesis in medaka, Oryzias latipe.

Iwanami N, Takahama Y, Kunimatsu S, Li J, Takei R, Ishikura Y, Suwa H, Niwa K, Sasado T, Morinaga C, Yasuoka A, Deguchi T, Hirose Y, Yoda H, Henrich T, Ohara 0, Kondoh H, Furutani-Seiki M. 2004

[雑誌論文] Ueno T, Saito F, Kuse S, Gray DHD, Nakano H, Kakiuchi T, Lipp M, CCR7 signals are essential for cortex-medulla migration of developing thymus.

Boyd RL, Takahama Y. 2004

[雑誌論文] T cell-specific disruption of aryl hydrocarbon receptor nuclear translocator gene causes resistance to 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced thymic involution.

Tomita S, Jiang HB, Ueno T, Takagi S, Tohi K, Maekawa S, Miyatake A, Furukawa A, Gonzalez FJ, Takeda J, Ichikawa Y, Takahama, Y. 2003

[雑誌論文] Deletion of the RAG2 C-terminus leads to impaired lymphoid development in mice.

Akamatsu Y, Monroe R, Dudley DD, Elkin SK, Gartner F, Talukder SR, Takahama Y, Alt FW, Bassing CH, Oettinger MA. 2003

[雑誌論文] In vivo treatment of class II MHC-deficient mice with anti-TCR antibody restores the generation of circulating CD4 T cells and optimal architecture of thymic medulla.

Nasreen M, Ueno T, Saito F, Takahama Y. 2003

[雑誌論文] Defective brain development in mice lacking HIF-1 alpha in neural cells.

Tomita S, Ueno M, Sakamoto M, Kitahama Y, Ueki M, Maekawa N, Sakamoto H, Gassmann M, Kageyama R, Ueda N, Gonzalez FJ, Takahama Y. 2003

[雑誌論文] Effect of CpG methylation on RAG1/RAG2 reactivity : implications of direct and indirect mechanism for controlling V(D)J cleavage.

Nakase H, Takahama Y, Akamatsu Y. 2003

胸腺器官発生因子TOF1及びTOF2両遺伝子とその用途