トップ研究者を探すサルモネラの食細胞内寄生の分子機構

サルモネラの食細胞内寄生の分子機構

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-16017218
研究種目 特定領域研究
研究分野
研究機関 千葉大学
代表研究者 山本 友子
研究分担者 友安 俊文
研究分担者 高屋 明子
研究期間 開始年月日 2004/4/1
研究期間 終了年度 2005
研究ステータス 完了 (2005/4/1)
配分額(合計) 14,700,000 (直接経費 :14,700,000)
配分額(履歴) 2005年度:7,300,000 (直接経費 :7,300,000)
2004年度:7,400,000 (直接経費 :7,400,000)
キーワード 病原性
サルモネラ
細胞内寄生
マクロファージ
マクロファージ内増殖能
ClpXP
PagC
OMV
attenuating virulence factor
持続感染
アポトーシス
細胞内寄生菌
Pathogenesis
Salmonella
Intracellular Growth
Macrophage

研究成果

[雑誌論文] The DnaK chaperone machinery converts the native FlhD2C2 hetero-tetramer into a functional transcriptional regulator of flagellar regulon expression in Salmonella.

A.Takaya, M.Matsui, T.Tomoyasu, M.Kaya, T.Yamamoto 2006

[雑誌論文] The DnaK chaperone machinery converts the native FlhD_2C_2 hetero-tetramer into a functional transcriptional regulator of flagellar regulon expression in Salmonella

Takaya, A., Matsui, M., Tomoyasu, T., Kaya, M., Tamamoto, T. 2006

[雑誌論文] The DnaK chaperone machinery converts the native F1hD2C2 hetero-tetramer into a functional transcriptional regulator of flagellar regulon expression in Salmonella.

A.Takaya, M.Matsui, T.Tomoyasu, M.Kaya, T.Yamamoto. 2006

[雑誌論文] Derepression of Salmonella pathogenicity island 1 genes within macrophages leads to rapid apoptosis via caspase-1- and caspase-3-dependent pathways

A.Takaya, A.Suzuki, Y.Kikuchi, M.Eguchi, E.Isogai, T.Tomoyasu, T.Yamamoto 2005

[雑誌論文] Derepression of Salmonella pathogenicity island 1 genes within macrophages leads to rapid apoptosis via caspase-1-and caspase-3- dependent pathways.

A.Takaya, A.Suzuki, Y.Kikuchi, M.Eguchi, E.Isogai, T.Tomoyasu, T.Yamamoto 2005

[雑誌論文] ClpXP controls the expression of LEE genes in enterohaemorrhagic Escherichia coli

Tomoyasu, T., Takaya, A., Handa, Y., Karata, K., Yamamoto, T. 2005

[雑誌論文] Derepression of Salmonella pathogenicity island 1 genes within macrophages leads to rapid apoptosis via caspase-1- and caspase-3-dependent pathways

A.Takaya, A.Suzuki, Y.Kikuchi, M.Eguchi, E.Isogai, T.Tomoyasu, T.Yamamoto 2005

[雑誌論文] The DnaK-DnaJ chaperone machinery of Salmonella enterica serovar Typhimurium is essential for invasion of epithelial cells and survival in macrophages, leading to systemic infection.

A.Takaya, T.Tomoyasu, H.Matsui, T.Yamamoto 2004

[雑誌論文] The DnaK-DnaJ chaperone machinery of Salmonella enterica serovar Typhimurium is essential for invasion of epithelial cells and survival in macrophages, leading to systemic infection.

A.Takaya, T.Tomoyasu, H.Matsui, T.Yamamoto 2004

[雑誌論文] A new heat shock gene agsA, which encodes a small chaperone involved in suppressing protein aggregation in Salmonella entrica serovar Typhimurium

T.Tomoyasu, A.Takaya, T.Sasaki, T.Nagase, R.Kikuno, M.Morioka, T.Yamamoto 2003

[雑誌論文] Turnover of FlhD and FlhC, master regulator proteins for Salmonella flagellum biogenesis, by the ATP-dependent ClpXP protease.

T.Tomoyasu, A.Takaya, E.Isogai, T.Yamamoto 2003

[雑誌論文] a stress-induced ATP-dependent protease, is critically important for the systemic Salmonella enterica serovar Typhimurium infection of mice.

A.Takaya, M.Suzuki, H.Matsui, T.Tomoyasu, H.Sashinami, A.Nakane, T.Yamamoto, Lon 2003

[雑誌論文] master regulator proteins for Salmonella flagellum biogenesis, by the ATP-dependent C1pXP protease.

T.Tomoyasu, A.Takaya, E.Isogai, T.Yamamoto, Turnover of F1hD, F1hC 2003

[雑誌論文] A new heat-shock gene agsA, which encodes a small chaperone involved in suppressing protein aggregation in Salmonella enterica serovar Typhimurium.

T.Tomoyasu, A.Takaya, T.Sasaki, T.Nagase, R.Kikuno, M.Morioka, T.Yamamoto 2003

[雑誌論文] Oral immunization with ATP-dependent protease-deficient mutants protects mice against subsequent oral challenge with virulent Salmonella enterica serovar Typhimurium.

H.Matsui, M.Suzuki, Y.Isshiki, M.Eguchi, Y.Kikuchi, K.Motokawa, A.Takaya, T.Tomoyasu, T.Yamamoto 2003

[雑誌論文] Lon, a stress induced ATP-dependent protease is critically important for the systemic Salmonella infection of mice.

A.Takaya, M.Suzuki, H.Matsui, T.Tomoyasu, H.Sashinami, A.Nakane, T.Yamamoto 2003