トップ›研究者を探す›脳内AT2受容体およびHDAC2の相互作用による認知機能への影響

脳内AT2受容体およびHDAC2の相互作用による認知機能への影響

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-15K19974
研究種目 若手研究(B)
研究分野 生物系
医歯薬学
外科系臨床医学
脳神経外科学
研究機関 愛媛大学
代表研究者 岩波 純
研究期間 開始年月日 2015/4/1
研究期間 終了年度 2016
研究ステータス 完了 (2016/4/1)
配分額（合計） 4,030,000 (直接経費 :3,100,000、間接経費 :930,000)
配分額（履歴） 2016年度：1,950,000 (直接経費 :1,500,000、間接経費 :450,000)
2015年度：2,080,000 (直接経費 :1,600,000、間接経費 :480,000)
キーワード 認知機能
血管性認知症
レニン・アンジオテンシン系
エピジェネティクス
アンジオテンシンII2型受容体
ヒストン脱アセチル化酵素２

研究成果

[学会発表] AT2 receptor stimulation reduces stroke size in concert with AT2 receptor-interacting protein

Jun Iwanami, Masaki Mogi, Xiao-Li Wang, Kana Tsukuda, Akinori Higaki, Masanori Kukida, Hirotomo Nakaoka, Toshifumi Yamauchi, Hui-Yu Bai, Bao-Shuai Shan, Li-Juan Min, Masatsugu Horiuchi 2017

[学会発表] Attenuation of Stroke Damage by Angiotensin II Type 2 Receptor Stimulation via Peroxisome Proliferator-Activated Receptor-gamma Activation

Jun Iwanami, Bao-Shuai Shan, Masaki Mogi, Hui-Yu Bai, Masayoshi Kukida, Toshihiro Yamauchi, Akinori Higaki, Li-Juan Min, Masatsugu Horiuchi 2017

[雑誌論文] Administration of bovine casein-derived peptide prevents cognitive decline in Alzheimer disease model mice.

Min LJ, Kobayashi Y, Mogi M, Tsukuda K, Yamada A, Yamauchi K, Abe F, Iwanami J, Xiao JZ, Horiuchi M 2017

[学会発表] Deficiency of Angiotensin Converting Enzyme 2 Causes Deterioration of Cognitive Function

Jun Iwanami, Masaki Mogi, Xiao-Li Wang, Kana Tsukuda, Akinori Higaki, Masanori Kukida, Hirotomo Nakaoka, Toshifumi Yamauchi, Hui-Yu Bai, Bao-Shuai Shan, Li-Juan Min, Masatsugu Horiuchi 2016

[学会発表] Cognitive Impairment in Angiotensin Converting Enzyme 2 Deficient Mice

Jun Iwanami, Masaki Mogi, Xiao-Li Wang, Kana Tsukuda, Akinori Higaki, Masanori Kukida, Hirotomo Nakaoka, Toshifumi Yamauchi, Hui-Yu Bai, Bao-Shuai Shan, Li-Juan Min, Masatsugu Horiuchi 2016

[雑誌論文] Synergistic Inhibitory Effect of Rosuvastatin and Angiotensin II Type 2 Receptor Agonist on Vascular Remodeling.

Bai HY, Mogi M, Nakaoka H, Kan-No H, Tsukuda K, Wang XL, Shan BS, Kukida M, Yamauchi T, Higaki A, Min LJ, Iwanami J, Horiuchi M 2016

[雑誌論文] Enhancement of Adipocyte Browning by Angiotensin II Type 1 Receptor Blockade.

Tsukuda K, Mogi M, Iwanami J, Kanno H, Nakaoka H, Wang XL, Bai HY, Shan BS, Kukida M, Higaki A, Yamauchi T, Min LJ, Horiuchi M 2016

[学会発表] Possible Epigenetic Modulation of Cerebral Angiotensin Type 2 Receptor in the Cognitive Function in Vascular Dementia

Jun Iwanami, Masaki Mogi, Kana Tsukuda, Xiao-Li Wang, Akinori Higaki, Masanori Kukida, Hirotomo Nakaoka, Toshifumi Yamauchi, Hui-Yu Bai, Bao-Shuai Shan, Li-Juan Min, Masatsugu Horiuchi 2016

[学会発表] AT2 receptor-interacting protein ameliorates cognitive deficit induced by chronic cerebral hypoperfusio

Jun Iwanami, Masaki Mogi, Xiao-Li Wang, Kana Tsukuda, Akinori Higaki, Masanori Kukida, Hirotomo Nakaoka, Toshifumi Yamauchi, Hui-Yu Bai, Bao-Shuai Shan, Li-Juan Min, Masatsugu Horiuchi 2016

[学会発表] 脳内ATIPによる認知機能低下予防効果

岩波純、茂木正樹、佃架奈、王小俐、中岡裕智、檜垣彰典、莖田昌敬、山内俊史、白薈鈺、単宝帥、閔莉娟、堀内正嗣 2016

[雑誌論文] Low-Protein Diet-Induced Fetal Growth Restriction Leads to Exaggerated Proliferative Response to Vascular Injury in Postnatal Life.

Chisaka T, Mogi M, Nakaoka H, Kan-No H, Tsukuda K, Wang XL, Bai HY, Shan BS, Kukida M, Iwanami J, Higaki T, Ishii E, Horiuchi M. 2016

[雑誌論文] Diabetic mice exhibited a peculiar alteration in body composition with exaggerated ectopic fat deposition after muscle injury due to anomalous cell differentiation.

Mogi M, Kohara K, Nakaoka H, Kan-No H, Tsukuda K, Wang XL, Chisaka T, Bai HY, Shan BS, Kukida M, Iwanami J, Miki T, Horiuchi M 2016

[雑誌論文] Interferon regulatory factor 1 attenuates vascular remodeling; roles of angiotensin II type 2 receptor.

Nakaoka H, Mogi M, Suzuki J, Kan-No H, Min LJ, Iwanami J, Horiuchi M. 2016

[雑誌論文] Angiotensin II Type 2 Receptor Inhibits Vascular Intimal Proliferation With Activation of PPARγ

Kukida M, Mogi M, Ohshima K, Nakaoka H, Iwanami J, Kanno H, Tsukuda K, Chisaka T, Min LJ, Wang XL, Bai HY, Shan BS, Higaki A, Yamauchi T, Okura T, Higaki J, Horiuchi M. 2016

[学会発表] Cerebral AT2 receptor-interacting protein enhances protective effects of AT2 receptor stimulation on ischemic brain damage

Jun Iwanami, Masaki Mogi, Xiao-Li Wang, Kana Tsukuda, Akinori Higaki, Masanori Kukida, Hirotomo Nakaoka, Toshifumi Yamauchi, Hui-Yu Bai, Bao-Shuai Shan, Li-Juan Min, Masatsugu Horiuchi 2016

[学会発表] 脳内IRF-1欠損による認知機能への影響

岩波純、茂木正樹、佃架奈、王小俐、中岡裕智、檜垣彰典、莖田昌敬、山内俊史、白薈鈺、単宝帥、閔莉娟、堀内正嗣 2016

[雑誌論文] Direct angiotensin II type 2 receptor stimulation by compound 21 prevents vascular dementia.

Iwanami J, Mogi M, Tsukuda K, Wang XL, Nakaoka H, Kan-no H, Chisaka T, Bai HY, Shan BS, Kukida M, Horiuchi M. 2015

[雑誌論文] Angiotensin II Type 2 Receptor Inhibits Vascular Intimal Proliferation With Activation of PPARγ.

Kukida M, Mogi M, Ohshima K, Nakaoka H, Iwanami J, Kanno H, Tsukuda K, Chisaka T, Min LJ, Wang XL, Bai HY, Shan BS, Higaki A, Yamauchi T, Okura T, Higaki J, Horiuchi M. 2015

[雑誌論文] e-treatment with LCZ696, an orally active angiotensin receptor neprilysin inhibitor, prevents ischemic brain damage.

Bai HY, Mogi M, Nakaoka H, Kan-No H, Tsukuda K, Chisaka T, Wang XL, Kukida M, Shan BS, Yamauchi T, Higaki A, Iwanami J, Horiuchi M. 2015

[学会発表] 血管性認知症モデルマウスにおける脳内AT2受容体とHDAC2阻害による改善効果

岩波純、茂木正樹、佃架奈、王小俐、中岡裕智、檜垣彰典、莖田昌敬、山内俊史、白薈鈺、単宝帥、閔莉娟、堀内正嗣 2015

[学会発表] 脳内AT2受容体とHDAC2阻害による認知機能低下抑制効果

岩波純、茂木正樹、佃架奈、王小俐、中岡裕智、檜垣彰典、莖田昌敬、山内俊史、白薈鈺、単宝帥、閔莉娟、堀内正嗣 2015

[雑誌論文] Angiotensin II type 2 receptor signaling affects dopamine levels in the brain and prevents binge eating disorder.

Nakaoka H, Mogi M, Kan-No H, Tsukuda K, Ohshima K, Wang XL, Chisaka T, Bai HY, Shan BS, Kukida M, Iwanami J, Horiuchi M 2015

[学会発表] 慢性脳低灌流モデルマウスにおける脳内ATIPの役割

岩波純、茂木正樹、佃架奈、王小俐、中岡裕智、檜垣彰典、莖田昌敬、山内俊史、白薈鈺、単宝帥、閔莉娟、堀内正嗣 2015

[学会発表] 血管性認知症モデルマウスにおける脳内IRF-1の役割

岩波純、茂木正樹、佃架奈、王小俐、中岡裕智、檜垣彰典、莖田昌敬、山内俊史、白薈鈺、単宝帥、閔莉娟、堀内正嗣 2015