トップ研究者を探す神経構造・機能画像を統合した筋萎縮性側索硬化症の新規バイオマーカーの開発

神経構造・機能画像を統合した筋萎縮性側索硬化症の新規バイオマーカーの開発

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-15K19487
研究種目 若手研究(B)
研究分野 生物系
医歯薬学
内科系臨床医学
神経内科学
研究機関 徳島大学
代表研究者 佐光 亘
研究期間 開始年月日 2015/4/1
研究期間 終了年度 2016
研究ステータス 完了 (2016/4/1)
配分額(合計) 2,600,000 (直接経費 :2,000,000、間接経費 :600,000)
配分額(履歴) 2016年度:1,170,000 (直接経費 :900,000、間接経費 :270,000)
2015年度:1,430,000 (直接経費 :1,100,000、間接経費 :330,000)
キーワード 筋萎縮性側索硬化症
バイオマーカー
MRI
fMRI
DTI
機能的MRI
fractional anisotropy

研究成果

[雑誌論文] MR Spectroscopy in Patients with Hereditary Diffuse Leukoencephalopathy with Spheroids and Asymptomatic Carriers of Colony-stimulating Factor 1 Receptor Mutation

Takashi Abe, Toshitaka Kawarai, Koji Fujita, Wataru Sako, Yuka Terasawa, Tsuyoshi Matsuda, Waka Sakai, Ai Tsukamoto-Miyashiro, Naoko Matsui, Yuishin Izumi, Ryuji Kaji, Masafumi Harada 2017

[雑誌論文] Spontaneous brain activity in the sensorimotor cortex in amyotrophic lateral sclerosis can be negatively regulated by corticospinal fiber integrity

Wataru Sako, Takashi Abe, Yuishin Izumi, Hiroki Yamazaki, Naoko Matsui, Masafumi Harada, Ryuji Kaji 2017

[雑誌論文] The utility of the combination of a SPECT study with [123I]-FP-CIT of dopamine transporters and [123I]-MIBG myocardial scintigraphy in differentiating Parkinson disease from other degenerative parkinsonian syndromes

Naoto Uyama, Hideki Otsuka, Takayoshi Shinya, Yoichi Otomi, Masafumi Harada, Wataru Sako, Yuishin Izumi, Ryuji Kaji, Yuya Watanabe, Satoru Takashi, Yamato Kunikane 2017

[雑誌論文] Parkinson’s disease-related network topographies characterized with resting state functional MRI

An Vo, Wataru Sako, Koji Fujita, Shichun Peng, Paul J. Mattis, Frank M. Skidmore, Yilong Ma, Aziz M. Ulug, David Eidelberg 2017

[雑誌論文] Imaging-based differential diagnosis between multiple system atrophy and Parkinson’s disease

Wataru Sako, Takashi Abe, Nagahisa Murakami, Yoshimichi Miyazaki, Yuishin Izumi, Masafumi Harada, Ryuji Kaji 2016

[雑誌論文] Fractional anisotrophy in the supplementary motor area correlates with disease duration and severity of amyotrophic lateral sclerosis

Wataru Sako, Takashi Abe, Yuishin Izumi, Masafumi Harada, Ryuji Kaji 2016

[学会発表] Neuroimagingを用いた神経変性疾患に対する新規バイオマーカー開発

佐光 亘 2016

[学会発表] 上小脳脚異常に基づくパーキンソン症候群鑑別

佐光 亘, 村上永尚, 和泉唯信, 梶 龍兒 2016

[雑誌論文] The ratio of N-acetyl aspartate to glutamate correlates with disease duration of amyotrophic lateral sclerosis

Wataru Sako, Takashi Abe, Yuishin Izumi, Masafumi Harada, Ryuji Kaji 2016

[学会発表] Imaging-based differential diagnosis between multiple system atrophy and Parkinson’s disease

Wataru Sako, Takashi Abe, Nagahisa Murakami, Yoshimichi Miyazaki, Yuishin Izumi, Masafumi Harada, Ryuji Kaji 2016

[雑誌論文] The difference of apparent diffusion coefficient in the middle cerebellar peduncle among parkinsonian syndromes: Evidence from a meta-analysis

Wataru Sako, Nagahisa Murakami, Yoshimichi Miyazaki, Yuishin Izumi, Ryuji Kaji 2016

[雑誌論文] Distinct brain networks underlie cognitive dysfunction in Parkinson and Alzheimer diseases

Paul J. Mattis, Martin Niethammer, Wataru Sako, Chris C. Tang, Amir Nazem, Marc L. Gordon, Vicky Brandt, Vijay Dhawan, David Eidelberg 2016

[学会発表] Neuroimagingを用いた神経疾患に対する新規バイオマーカー開発

佐光 亘 2016

[雑誌論文] On-period unified Parkinson’s disease rating scale before surgery correlates with differences in outcomes between pallidal and subthalamic stimulation: a meta-analysis

Wataru Sako, Takashi Abe, Yuishin Izumi, Masafumi Harada, Ryuji Kaji 2016

[学会発表] 筋萎縮性側索硬化症における脳機能ネットワーク独立性の消失

佐光 亘, 阿部考志, 原田雅史, 和泉唯信, 梶 龍兒 2016

[学会発表] MSAの早期診断とバイオマーカー

佐光 亘 2016

[学会発表] 筋萎縮性側索硬化症における低周波帯域の安静時脳機能MRI信号変化とFA値の関係

佐光 亘, 阿部考志, 原田雅史, 和泉唯信, 梶 龍兒 2016

[学会発表] The effect of corticospinal fiber integrity on spontaneous brain activity in the sensorimotor cortex in amyotrophic lateral sclerosis

Wataru Sako, Takashi Abe, Yuishin Izumi, Naoko Matsui, Masafumi Harada, Ryuji Kaji 2016

[雑誌論文] The effect of tremor onset on middle cerebellar peduncle of Parkinson’s disease

Wataru Sako, Nagahisa Murakami, Yoshimichi Miyazaki, Takashi Abe, Masafumi Harada, Yuishin Izumi, Ryuji Kaji 2015

[雑誌論文] How sick are dialysis patients undergoing cholecystectomy? Analysis of 92,672 patients from the American College of Surgeons National Surgical Quality Improvement Program database

Sophia F. Tam, Joyce T. Au, Wataru Sako, Antonio E. Alfonso, Gainosuke Sugiyama 2015

[雑誌論文] 18FDG-microPET and MR DTI findings in Tor1a+/- heterozygous knock-out mice

An Vo, Wataru Sako, Stephen L. Dewey, David Eidelberg, Aziz M. Ulug 2015

[雑誌論文] Neurofilament light chain level in cerebrospinal fluid can differentiate Parkinson’s disease from atypical parkinsonism: Evidence from a meta-analysis

Wataru Sako, Nagahisa Murakami, Yuishin Izumi, Ryuji Kaji 2015

[学会発表] Abnormal neural activity in natural motion perception in DYT1 dystonia

佐光 亘, An Vo, Aziz M. Ulug, David Eidelberg 2015

[雑誌論文] Val66Met polymorphism of brain-derived neurotrophic factor is associated with primary dystonia: A meta-analysis of case-control studies

Wataru Sako, Nagahisa Murakami, Yuishin Izumi, Ryuji Kaji 2015

[雑誌論文] Metabolic resting-state brain networks in health and disease

Phoebe G. Spetsieris, Ji Hyun Ko, Chris C. Tang, Amir Nazem, Wataru Sako, Shichun Peng, Yilong Ma, Vijay Dhawan, David Eidelberg 2015

[学会発表] 筋萎縮性側索硬化症における低周波帯域の安静時脳機能MRI信号変化

佐光 亘, 阿部考志, 原田雅史, 和泉唯信, 梶 龍兒 2015

[雑誌論文] The visual perception of natural motion: abnormal task-related neural activity in DYT1 dystonia

Wataru Sako, Koji Fujita, An Vo, Janet Rucker, John-Ross Rizzo, Martin Niethammer, Maren Carbon, Susan Bressman, Aziz M. Ulug, David Eidelberg 2015

[雑誌論文] Thalamocortical connectivity correlates with phenotypic variability in dystonia

An Vo, Wataru Sako, Martin Niethammer, Maren Carbon, Susan Bressman, Aziz Ulug, David Eidelberg 2015

[学会発表] The effect of tremor onset on middle cerebellar peduncle of Parkinson’s disease

佐光 亘, 村上永尚, 宮崎由道, 阿部考志, 原田雅史, 和泉唯信, 梶 龍兒 2015

[雑誌論文] Clinical Significance of Discrepancy between Arterial Spin Labeling Images and Contrast-enhanced Images in the Diagnosis of Brain Tumors

Takashi Abe, Yoshifumi Mizobuchi, Wataru Sako, Saho Irahara, Yoichi Otomi, Yuki Obama, Kohei Nakajima, Delgerdalai Khashbat, Mungunkhuyag Majigsuren, Teruyoshi Kageji, Shinji Nagahiro, Masafumi Harada 2015