研究成果

[雑誌論文] Daily Coffee Intake Inhibits Pancreatic Beta Cell Damage and Nonalcoholic Steatohepatitis in a Mouse Model of Spontaneous Metabolic Syndrome, Tsumura-Suzuki Obese Diabetic Mice.

Watanabe S, Takahashi T, Ogawa H, Uehara H, Tsunematsu T, Baba H, Morimoto Y, Tsuneyama K. 2017

[雑誌論文] Primary Biliary Cholangitis: Its Pathological Characteristics and Immunopathological Mechanisms

Tsuneyama K, Baba H, Morimoto Y, Tsunematsu T, Ogawa H. 2017

[雑誌論文] Toxicological role of an acyl glucuronide metabolite in diclofenac-induced acute liver injury in mice.

Oda S, Shirai Y, Akai S, Nakajima A, Tsuneyama K, Yokoi T. 2017

[雑誌論文] Human β-Defensin 2 in Primary Sclerosing Cholangitis.

Chang C, Lleo A, Kananurak A, Grizzi F, Tsuneyama K, Invernizzi P, Bevins CL, Bowlus CL. 2017

[雑誌論文] Chemokine receptor CXCR3 deficiency exacerbates murine autoimmune cholangitis by promoting pathogenic CD8(+) T cell activation.

Ma HD, Ma WT, Liu QZ, Zhao ZB, Liu MZ, Tsuneyama K, Gao JM, Ridgway WM, Ansari AA, Gershwin ME, Fei YY, Lian ZX. 2017

[雑誌論文] Prolonged activation of IL-5-producing ILC2 causes pulmonary arterial hypertrophy.

Ikutani M, Tsuneyama K, Kawaguchi M, Fukuoka J, Kudo F, Nakae S, Arita M, Nagai Y, Takaki S, Takatsu K. 2017

[雑誌論文] Establishment of a mouse model of enalapril-induced liver injury and investigation of the pathogenesis.

Shirai Y, Oda S, Makino S, Tsuneyama K, Yokoi T. 2017

[学会発表] 異なるメカニズムに起因する新しい肝細胞癌発症モデル動物の開発と病態解析、及び治療法解明への応用

常山幸一 2016

[雑誌論文] Aberrant iron metabolism might have an impact on progression of diseases in Tsumura Suzuki obese diabetes mice, a model of spontaneous metabolic syndrome.

Nishida T, Tsuneyama K, Fujimoto M, Nomoto K, Hayashi S, Miwa S, Nakajima T, Nakanishi Y, Hatta H, Imura J. 2016

[雑誌論文] Kupffer cell-mediated exacerbation of methimazole-induced acute liver injury in rats.

Akai S, Uematsu Y, Tsuneyama K, Oda S, Yokoi T. 2016

[雑誌論文] ORAL ADMINISTRATION OF a-LIPOIC ACID INCREASES SERUM LEVELS OF ASCORBIC ACID AND TOCOPHEROL: A PILOT HEMATOLOGICAL STUDY

Takahashi T, Baba H, Hatta H, Ogawa H, Uehara H, Nishida Y, Kataguchi I, Tsuneyama K 2016

[雑誌論文] Histopaythologival characteristics of glutamine syntheses-positive hepatic tumor lesions in a mouse model of spontaneous metabolic syndrome (TSOD mouse)

Takahashi T, Nishida T, Baba H, Hatta H, Imura J, Sutoh M, Toyohara S, Hokao R, Watanabe S, Ogawa H, Uehara H, Tsuneyama K 2016

[雑誌論文] HIF-1α in Myeloid Cells Promotes Adipose Tissue Remodeling Toward Insulin Resistance.

Takikawa A, Mahmood A, Nawaz A, Kado T, Okabe K, Yamamoto S, Aminuddin A, Senda S, Tsuneyama K, Ikutani M, Watanabe Y, Igarashi Y, Nagai Y, Takatsu K, Koizumi K, Imura J, Goda N, Sasahara M, Matsumoto M, Saeki K, Nakagawa T, Fujisaka S, Usui I, Tobe K. 2016

[雑誌論文] Liver disease risk of xenobiotics due to percutaneous absorption revealed by nano-PALDI imaging mass spectrometry.

Taira S, Yamaguchi N, Morimoto S, Tatsuta Y, Katano H, Ichiyanagi Y, tsuneyama K, Kikuchi K. 2016

[学会発表] New animal models of metabolic syndrome-associated liver cancer

Koichi Tsuneyama 2016

[学会発表] メタボリックシンドローム関連肝疾患に出現するautoimmune featuresの臨床病理学的特徴

常山幸一 2016

[雑誌論文] Endogenous interleukin-22 protects against inflammatory bowel disease but not autoimmune cholangitis in dominant negative form of transforming growth factor beta receptor type II mice.

Yang GX, Sun Y, Tsuneyama K, Zhang W, Leung PS, He XS, Ansari AA, Bowlus C, Ridgway WM, Gershwin ME. 2016

[学会発表] 新生児期ストレプトゾトシン投与４CS系マウスは通常食飼育によって持続高血糖なし に肝腫瘍を発症する

常山幸一、小川博久、常松貴明、上原久典 2016

[雑誌論文] Chronic expression of interferon-gamma leads to murine autoimmune cholangitis with a female predominance.

Bae HR, Leung PS, Tsuneyama K, Valencia JC, Hodge DL, Kim S, Back T, Karwan M, Merchant AS, Baba N, Feng D, Park O, Gao B, Yang GX, Gershwin ME, Young HA. 2016

[雑誌論文] Zomepirac Acyl Glucuronide Is Responsible for Zomepirac-Induced Acute Kidney Injury in Mice.

Iwamura A, Watanabe K, Akai S, Nishinosono T, Tsuneyama K, Oda S, Kume T, Yokoi T. 2016

[雑誌論文] A diagnostic marker for superficial urothelial bladder carcinoma: lack of nuclear ATBF1 (ZFHX3) by immunohistochemistry suggests malignant progression.

Kawaguchi M, Hara N, Bilim V, Koike H, Suzuki M, Kim TS, Gao N, Dong Y, Zhang S, Fujinawa Y, Yamamoto O, Ito H, Tomita Y, Naruse Y, Sakamaki A, Ishii Y, Tsuneyama K, Inoue M, Itoh J, Yasuda M, Sakata N, Jung CG, Kanazawa S, Akatsu H, Minato H, Nojima T, Asai K, Miura Y. 2016

[学会発表] 機能化した磁性ナノ微粒子を用いたマウス肝臓質量分析イメージング

森本翔大、兵藤公美典、山崎貴大、石川智也、平修、常山幸一、一柳優子 2015

[雑誌論文] Accumulated myeloid-derived suppressor cells demonstrate distinct phenotypes and functions in two non-alcoholic steatohepatitis mouse models.

Tsunashima H, Tsuneyama K, Moritoki Y, Hara M, Kikuchi K. 2015

[雑誌論文] Successful treatment of murine autoimmune cholangitis by parabiosis: Implications for hematopoietic therapy.

Yang JB, Wang YH, Yang W, Lu FT, Ma HD, Zhao ZB, Jia YJ, Tang W, Tsuneyama K, Ridgway WM, Gershwin ME, Lian ZX. 2015

[雑誌論文] Gastrointestinal Immune Response to the Shrimp Allergen Tropomyosin: Histological and Immunological Analysis in an Animal Model of Shrimp Tropomyosin Hypersensitivity.

Lam YF, Tong KK, Kwan KM, Tsuneyama K, Shu SA, Leung PS, Chu KH. 2015

[学会発表] メタボリックシンドローム関連肝疾患モデル動物の開発と応用

常山幸一 2015

[学会発表] Hyperinsulinemia, not hyperglycemia accelerates the progression of hepatocellular carcinoma in neonatal STZ induced mouse model

Ryosuke Bessho, Masahiro Miki, Hayato Baba, Koichi Tsuneyama 2015

[学会発表] Nano-PALDI MSイメージングを用いた 経皮吸収の薬物動態解析

山口菜月、菊池健太郎、常山幸一、森本翔大、一柳優子、片野肇、平修 2015

[学会発表] Mass spectrometric imaging of mouse livers using functional γ-Fe2O3 nanoparticles

Morimoto S, Ishikawa T, Hyodo K, Yamazaki T, Taira S, Tsuneyama K, ichiyanagi Y. 2015