トップ研究者を探す脳梗塞発症後のマクロファージ活性化とその制御による脳保護作用

脳梗塞発症後のマクロファージ活性化とその制御による脳保護作用

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-15K10306
研究種目 基盤研究(C)
研究分野 生物系
医歯薬学
外科系臨床医学
脳神経外科学
研究機関 福岡大学
徳島大学
代表研究者 八木 謙次
研究分担者 宇都 義浩
研究分担者 永廣 信治
研究期間 開始年月日 2015/4/1
研究期間 終了年度 2017
研究ステータス 完了 (2017/4/1)
配分額(合計) 4,810,000 (直接経費 :3,700,000、間接経費 :1,110,000)
配分額(履歴) 2017年度:780,000 (直接経費 :600,000、間接経費 :180,000)
2016年度:2,340,000 (直接経費 :1,800,000、間接経費 :540,000)
2015年度:1,690,000 (直接経費 :1,300,000、間接経費 :390,000)
キーワード 脳・神経
脳梗塞
M1/M2様マクロファージ
炎症性サイトカイン
phagocytosis
神経再生
M1/M2マクロファージ
炎症性サイトカイン

研究成果

[雑誌論文] Cryptic recanalization of chronic vertebral artery occlusion by head rotation

Yagi K, Nakagawa H, Mure H, Okita S, Nagahiro S 2017

[雑誌論文] Coexistence of Quasi-moyamoya Disease and POEMS Syndrome in a Patient with Intracranial Hemorrhage: A Case Report and Literature Review

Yamaguchi I, Satomi J, Yamamoto N, Yoshioka S, Tada Y, Yagi K, Kanematsu Y, Nagahiro S 2017

[学会発表] Activation of M2 macrophages in the late phase of cerebral ischema may contribute to phagocytosis of infract area and neurogenesis

Y. Kurashiki, K.T. Kitazato, K. Shimada, K. Yagi, Y. Tada, T. Kinouchi, M. Sumiyoshi, T. Miyamoto, T. Yamaguchi, J. Satomi, Y. Uto, S. Nagahiro 2016

[学会発表] A Pilot Study of the Mineralocorticoid Receptor Blocker Eplerenone in Hypertensive Patients with Unruptured Cerebral Aneurysms

J. Satomi, Y. Tada, Y. Kanematsu, K. Kuwayama, K. Yagi, T. Kinouchi, K. Nakajima, N. Matsushita, T. Miyamoto, T. Yamaguchi, M. Korai, H. Mure, K. T. Kitazato, S. Nagahiro 2016

[学会発表] Porphyromonas gingivalis lipopolysaccharide enhances the rupture of intracranial aneurysms in rats

T. Miyamoto, K.T. Kitazato, H. Maekawa, T. Yamaguchi, K. Shimada, K. Yagi, Y. Tada, Y. Kurashiki, S. Yoshioka, Y. Kanematsu, J. Satomi, S. Nagahiro 2016

[学会発表] Early Morphological Changes in Cerebral Arteries of Cerebral Aneurysm Rupture Model Rats

H. Maekawa, T. Miyamoto, K.T. Kitazato, K. Yagi, Y. Tada, K. Shimada, J. Satomi, S. Nagahiro 2016

[学会発表] Impact of Periodontal Disease and -Bacteria on Intracranial Aneurysms

S. Yoshioka, Y. Tada, J. Satomi, K. Yagi, K. Naruishi, K. Kuwayama, K. T. Kitazato, T. Miyamoto, Y. Kanematsu, M. Harada, T. Nagata, S. Nagahiro 2016

[学会発表] 3D structure of vasa vasorum in thrombosed rat cerebral aneurysms

H. Maekawa, T. Miyamoto, K.T. Kitazato, S. Nagahiro 2016

[学会発表] Activation of M2 macrophages in the late phase of cerebral ischema may contribute to phagocytosis of infract area and neurogenesis

Y. Kurashiki, K.T. Kitazato, K. Shimada, K. Yagi, Y. Tada, T. Kinouchi, M. Sumiyoshi, T. Miyamoto, T. Yamaguchi, J. Satomi, Y. Uto, S. Nagahiro 2016

[学会発表] Porphyromonas gingivalis lipopolysaccharide enhances the rupture of intracranial aneurysms in rats

T. Miyamoto, K.T. Kitazato, H. Maekawa, T. Yamaguchi, K. Shimada, K. Yagi, Y. Tada, Y. Kurashiki, S. Yoshioka, Y. Kanematsu, J. Satomi, S. Nagahiro 2016

[雑誌論文] Angiotensin-(1-7) protects against the development of aneurysmal subarachnoid hemorrhage in mice

Shimada K, Furukawa H, Wada K, Wei Y, Tada Y, Kuwabara A, Shikata F, Kanematsu Y, Lawton M, Kitazato K, Nagahiro S, Hashimoto T 2015

[雑誌論文] Protective Role of Peroxisome Proliferator-Activated Receptor-γ in the Development of Intracranial Aneurysm Rupture

Shimada K, Furukawa H, Wada K, Korai M, Wei Y, Tada Y, Kuwabara A, Shikata F, Kitazato KT, Nagahiro S, Lawton MT, Hashimoto T 2015

[雑誌論文] Intraoperative Arachnoid Plasty Has Possibility to Prevent Chronic Subdural Hematoma after Surgery for Unruptured Cerebral Aneurysms

Yagi K, Irie S, Inagaki T, Ishii Y, Saito O, Lee T, Nakagawa H, Saito K, Nagahiro S 2015

[雑誌論文] DIAS-J Investigators Safety and Tolerability of Desmoteplase Within 3 to 9 Hours After Symptoms Onset in Japanese Patients With Ischemic Stroke

Mori E, Minematsu K, Nakagawara J, Hasegawa Y, Nagahiro S, Okada Y, Truelsen T, Lindsten A, Ogawa A, Yamaguchi T 2015

[雑誌論文] Therapeutically Targeting Tumor Necrosis Factor-α/Sphingosine-1-Phosphate Signaling Corrects Myogenic Reactivity in Subarachnoid Hemorrhage

Yagi K, Lidington D, Wan H, Fares JC, Meissner A, Sumiyoshi M, Ai J1, Foltz WD, Nedospasov SA, Offermanns S, Nagahiro S, Macdonald RL, Bolz SS 2015