トップ研究者を探す免疫細胞と放射線増感剤併用における時間放射線生物学モデルの構築

免疫細胞と放射線増感剤併用における時間放射線生物学モデルの構築

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-15K09998
研究種目 基盤研究(C)
研究分野 生物系
医歯薬学
内科系臨床医学
放射線科学
研究機関 岡山大学
代表研究者 笈田 将皇
研究分担者 宇都 義浩
研究分担者 中田 一弥
研究分担者 吉見 陽児
研究協力者 富永 正英
研究協力者 勝井 邦彰
研究協力者 片山 敬久
研究期間 開始年月日 2015/4/1
研究期間 終了年度 2018
研究ステータス 完了 (2018/4/1)
配分額(合計) 4,550,000 (直接経費 :3,500,000、間接経費 :1,050,000)
配分額(履歴) 2017年度:1,300,000 (直接経費 :1,000,000、間接経費 :300,000)
2016年度:1,430,000 (直接経費 :1,100,000、間接経費 :330,000)
2015年度:1,820,000 (直接経費 :1,400,000、間接経費 :420,000)
キーワード 時間放射線生物学
免疫放射線療法
生物物理学的計算モデル
放射線感受性
最適化
生物物理理学計算モデル

研究成果

[雑誌論文] Effect of dose rate on antitumor activity in hypoxic cells by using flattening filter free beams

Hara T, Tominaga M, Yajyu K, Kouzaki R, Yamada H, Sasaki M, Azane S, Uto Y 2018

[雑誌論文] Immunologicalaspects of Improved Tumor and Normal Tissue Responses Using Biophysical modelling

Oita M, Udaka M, Aoyama H, Sasaki M, Tominaga M, Uto Y 2018

[学会発表] Immunologicalaspects of Improved Tumor and Normal Tissue Responses Using Biophysical modelling

Oita M, Udaka M, Aoyama H, Sasaki M, Tominaga M, Uto Y 2018

[雑誌論文] Photodynamic Therapy Mediated by a Novel Chlorin Derivative, TONS 501-Na, in EMT6 cells.

Osaki T, Sakata I, Uto Y, Azuma K, Murahata Y, Tsuka T, Itoh N, Imagawa T, Okamoto Y. 2017

[雑誌論文] Development of a novel Schiff base derivative for enhancing the anticancer potential of 5-aminolevulinic acid-based photodynamic therapy.

Shinohara Y, Endo Y, Abe C, Shiba I, Ishizuka M, Tanaka T, Yonemura Y, Ogura SI, Tominaga M, Yamada H, Uto Y. 2017

[雑誌論文] Design and Synthesis of Novel Anti-metastatic Hypoxic Cytotoxin TX-2137 Targeting AKT Kinase.

Shiba I, Kouzaki R, Yamada H, Endo Y, Takino T, Sato H, Kitazato K, Kageji T, Nagahiro S, Uto Y. 2017

[学会発表] Feasibility of dose delivery error detection by a transmission detector for patient - specific QA

H Honda, K Kubo, R Yamamoto, Y Ishii, H Kanzaki, Y Hamamoto, T Mochizuki, M Oita, M Sasaki, M Tominaga, Y Uto 2017

[雑誌論文] 1,2,3-Triazolyl esterization of PAK1-blocking propolis ingredients, artepillin C (ARC) and caffeic acid (CA), for boosting their anti-cancer/anti-PAK1 activities along with cell-permeability.

Takahashi H, Nguyen BCQ, Uto Y, Shahinozzaman M, Tawata S, Maruta H. 2017

[学会発表] マクロファージ活性化因子GcMAFの貪食活性化作用に関する受容体の同定と作用機序の解明

桑田 依洋,濱田 健,井亀 沙紀,青野 ゆかり,山田 久嗣,Martin Mette,久保 健太郎,乾 利夫,宇都 義浩 2017

[雑誌論文] Interactive Analysis of TX-1123 with Cyclo-oxygenase: Design of COX2 Selective TX Analogs.

Ohkura K, Tatematsu Y, Kawaguchi Y, Uto Y, Hori H. 2017

[雑誌論文] Both triazolyl ester of ketorolac (15K) and YM155 inhibit the embryonic angiogenesis <i>in ovo</i> (fertilized eggs) <i>via</i> their common PAK1-survivin/VEGF signaling pathway

Ahn MR, Bae JY, Jeong DH, Takahashi H, Uto Y, Maruta H. 2017

[学会発表] ウシ初乳由来マクロファージ活性化剤の創製と抗炎症作用機序の解明

桑田 依洋,濱田 健,井亀 沙紀,青野 ゆかり,山田 久嗣,Martin Mette,久保 健太郎,乾 利夫,宇都 義浩 2017

[雑誌論文] Case Report: A Non-small Cell Lung Cancer Patient Treated with GcMAF, Sonodynamic Therapy and Tumor Treating Fields.

Inui T, Amitani H, Kubo K, Kuchiike D, Uto Y, Nishikata T, Mette M 2016

[学会発表] Does the biophysical modelling for immunological aspects in radiotherapy precisely predict tumor and normal tissue responses?

M.Oita, K.Nakata, H.Aoyama, M.Sasaki, M.Tominaga, H.Hoda, Y.Uto 2016

[雑誌論文] Case Report: GcMAF Treatment in a Patient with Multiple Sclerosis

Inui T, Katsuura G, Kubo K, Kuchiike D, Chenery L, Uto Y, Nishikata T, Mette M 2016

[学会発表] Application of biophysical modelling for normal tissue response with immunological aspects in radiotherapy

M.Oita, H.Aoyama, M.Sasaki, M.Tominaga, H.Hoda, Y.Uto 2016

[雑誌論文] Does the biophysical modelling for immunological aspects in radiotherapy precisely predict tumor and normal tissue responses?

M.Oita, K.Nakata, H.Aoyama, M.Sasaki, M.Tominaga, H.Hoda, Y.Uto 2016

[雑誌論文] Macrophages Exhibit a Large Repertoire of Activation States via Multiple Mechanisms of Macrophage-activating Factors.

Sumiya YU, Inoue T, Ishikawa M, Inui T, Kuchiike D, Kubo K, Uto Y, Nishikata T 2016

[雑誌論文] Application of biophysical modelling for normal tissue response with immunological aspects in radiotherapy

M.Oita, H.Aoyama, M.Sasaki, M.Tominaga, H.Hoda, Y.Uto 2016

[雑誌論文] Macrophage Activation Mechanisms in Human Monocytic Cell Line-derived Macrophages.

Yu Sumiya, Mami Ishikawa, Takahiro Inoue, Toshio Inui, Daisuke Kuchiike, Kentaro Kubo, Yoshihiro Uto and Takahito Nishikata 2015

[雑誌論文] Degalactosylated/Desialylated Bovine Colostrum Induces Macrophage Phagocytic Activity Independently of Inflammatory Cytokine Production.

Yoshihiro Uto, Tomohito Kawai, Toshihide Sasaki, Ken Hamada, Hisatsugu Yamada, Daisuke Kuchiike, Kentaro Kubo, Toshio Inui, Martin Mette, Ken Tokunaga, Akio Hayakawa, Akiteru Go and Tomohiro Oosaki 2015