トップ研究者を探す自然肝発癌するNASHモデルマウスでのPPAR-αを介した発癌抑止の分子機構

自然肝発癌するNASHモデルマウスでのPPAR-αを介した発癌抑止の分子機構

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-15K09010
研究種目 基盤研究(C)
研究分野 生物系
医歯薬学
内科系臨床医学
消化器内科学
研究機関 高知大学
代表研究者 西原 利治
研究分担者 耕崎 拓大
研究分担者 戸田 勝巳
研究分担者 水田 洋
研究期間 開始年月日 2015/4/1
研究期間 終了年度 2017
研究ステータス 完了 (2017/4/1)
配分額(合計) 4,680,000 (直接経費 :3,600,000、間接経費 :1,080,000)
配分額(履歴) 2017年度:1,170,000 (直接経費 :900,000、間接経費 :270,000)
2016年度:1,560,000 (直接経費 :1,200,000、間接経費 :360,000)
2015年度:1,950,000 (直接経費 :1,500,000、間接経費 :450,000)
キーワード PPAR-alpha
melanocortin receptor
insulin resistance
fatty liver
IL-6
NASH
hepatocellular carcinoma
knockout mouse
Melanocortin receptor
肝硬変
肝細胞癌
MC4R
ノックアウトマウス

研究成果

[雑誌論文] Analysis of factors influencing glucose tolerance in Japanese patients with non-alcoholic fatty liver disease

Ohmi Satoko、Ono Masafumi、Takata Hiroshi、Hirano Seiki、Funakoshi Shogo、Nishi Yuichi、Yoshimura Kumiko、Amano Eri、Terada Yoshio、Saibara Toshiji、Fujimoto Shimpei 2018

[雑誌論文] Prevalence of pruritus in patients with chronic liver disease: a multicenter study.

Oeda S, Ono M, Saibara T, Eguchi Y(他16名) 2018

[雑誌論文] The novel cutoff points for the FIB4 index categorized by age increase the diagnostic accuracy in NAFLD: a multi-center study

Ishiba H, Sumida Y, Tanaka S, Yoneda M, Hyogo H, Ono M, Fujii H, Eguchi Y, Suzuki Y, Yoneda M, Takahashi H, Nakahara T, Seko Y, Mori K, Kanemasa K, Shimada K, Imai S, Imajo K, Kawaguchi T, Nakajima A, Chayama K, Saibara T、 Shima T, Fujimoto K, Okanoue T, Itoh Y 2018

[雑誌論文] Evaluation of postprandial hypoglycemia in patients with nonalcoholic fatty liver disease by oral glucose tolerance testing and continuous glucose monitoring

Oki Y, Ono M, Hyogo H, Ochi T, Munekage K, Nozaki Y, Hirose A, Masuda K, Mizuta H, Okamoto N, Saibara T 2018

[雑誌論文] New scoring system combining the FIB-4 index and cytokeratin-18 fragments for predicting steatohepatitis and liver fibrosis in patients with nonalcoholic fatty liver disease

Tada T, Kumada T, Toyoda H, Saibara T, Ono M, Kage M 2018

[学会発表] Vonoprazan-based third-line triple therapy in Helicobacter pyloli eradication and study of the diversity of antimicrobial susceptibilities

Yano Y,Mizuta H,Ono M,Nagano S,Tsuda H,Kitagawa T,Hashiba M,Okamoto N,Kira M,Takeuchi H,Matsumura Y,Saibara T 2017

[学会発表] Involvement of PNPLA3 function for hepatic lipids metabolism through XBP1 and modulation of endoplasmic reticulum stress in mice

Nagano S,Ono M,Ochi T,Munekage K,Yano Y,Mizuta H,Ogasawara M,Hirose A,Nozalki Y,Okamoto N,Iwasaki S,Jude A ObenT,Saibara T 2017

[学会発表] Functional roles of AGE-RAGE system for the development of hepatic fibrosis of NASH

Ono M,Munekage K,Ochi T,Hirose A,Ogasawara M,Okamoto N,Saibara T 2017

[学会発表] Efficient delivery of siRNA targeted CCDC88A mRNA topancreatic cancer tumor inhibits the invasiveness and metastasis

Taniuchi K,Yawata T,Ueda T,Saibara T 2017

[学会発表] A case of osteoclast-like giant cell tumor of the pancreas without epithelial differentiation.

Kohsaki T,Oe K, Kigi A, Saibara T,Munekage M,Hanazaki K 2016

[学会発表] PNPLA3 IS INVOLVED IN HEPATIC LIPIDS METABOLISM THROUGH XBP1 AND MODUALATION OF ENDOPLASMIC RETICULUM SYRESS IN MICE

Ono M,Ochi T,Munegage K,Ogasawara M,Hirose A,Nozaki-Fujimura Y,Okamoto N, Iwasaki S,Oben J,Saibara T 2016

[学会発表] INVOLVEMENT OF AGE-RAGE SYSTEM FOR THE DEVEL-OPMENT OF HEPATIC FIBROSIS IN NASH

Munegage K,Ono M,Ochi T,Ogasawara M,Hirose A,Fujimura Y ,Iwasaki S,Saibara T 2016

[雑誌論文] PNPLA3 is involved in hepatic fatty acid and triglyceride metabolism through XBP1 and modulation of endoplasmic reticulum stress in mice.

Ochi T, Munekage K, Ono M, Higuchi T, Tsuda M, Hayashi Y, Okamoto N, Toda K, Sakamoto S, Oben JA, Saibara T. 2016

[雑誌論文] Inhibition of Cyclic Adenosine Monophosphate (cAMP)-response Element-binding Protein (CREB)- binding Protein (CBP)/β-Catenin Reduces Liver Fibrosis in Mice.

Osawa Y, Oboki K, Imamura J, Kojika E, Hayashi Y, Hishima T, Saibara T, Shibasaki F, Kohara M, Kimura K 2015

[学会発表] C型慢性肝炎患者とNAFLD患者の血糖日中変動に影響を及ぼす要因についての比較検討.

越智経浩,小野正文,西原利治 2015