トップ研究者を探すPNPLA3遺伝子改変マウスを用いたERストレスを介するNASH発症・病因の解明

PNPLA3遺伝子改変マウスを用いたERストレスを介するNASH発症・病因の解明

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-15K09009
研究種目 基盤研究(C)
研究分野 生物系
医歯薬学
内科系臨床医学
消化器内科学
研究機関 高知大学
代表研究者 小笠原 光成
研究分担者 小野 正文
研究分担者 西原 利治
研究期間 開始年月日 2015/4/1
研究期間 終了年度 2017
研究ステータス 完了 (2017/4/1)
配分額(合計) 4,810,000 (直接経費 :3,700,000、間接経費 :1,110,000)
配分額(履歴) 2017年度:910,000 (直接経費 :700,000、間接経費 :210,000)
2016年度:1,300,000 (直接経費 :1,000,000、間接経費 :300,000)
2015年度:2,600,000 (直接経費 :2,000,000、間接経費 :600,000)
キーワード NASH
PNPLA3
遺伝子多型
PNPLA3 mutation
XBP-1
肝臓学

研究成果

[雑誌論文] Are donors or recipients a more important predictive factor for the development of non-alcoholic fatty liver disease after liver transplantation?

Ono Masafumi 2018

[学会発表] POTASSIUM-COMPETITIVE ACID BLOCKER-BASED THIRD-LINE TRIPLE THERAPY IN HELICOBACTER PY-LORI ERADICATION AND STUDY OF THE DIVERSITY OF ANTIMICROBIAL SUSCEPTIBILITIES

Yano Y,Mizuta H, Ono M,Saibara T.(他6名) 2017

[学会発表] Involvement of PNPLA3 function for hepatic lipids metabolism through XBP1 and modulation of endoplasmic reticulum stress in mice

Nagano S,Ono M,Ochi T,Munekage K,Yano Y,Mizuta H,Ogasawara M,Hirose A,Nozalki Y,Okamoto N,Iwasaki S, Oben JA, Saibara T 2017

[学会発表] :INVOLVEMENT OF AGE-RAGE SYSTEM FOR THE DEVEL-OPMENT OF HEPATIC FIBROSIS IN NASH

Munekage K,Ono M,Ochi T,Saibara T.(他4名) 2017

[学会発表] Characteristics of Japanese NAFLD/NASH

Ono M 2017

[学会発表] EFFICACY OF GLUTATHIONE FOR THE TREATMENT OF NON-ALCOHOLIC FATTY LIVER DISEASE:AN OPEN-LABEL, MULTICENTER, PROSPECTIVE STUDY

Kessoku T,Ono M,Eguchi Y,Nakajima A. (他13名) 2017

[雑誌論文] Efficacy of glutathione for the treatment of nonalcoholic fatty liver disease: an open-label, single-arm, multicenter, pilot study

Honda Y, Ono M, Nakajima A(他20名) 2017

[雑誌論文] Analysis of factors influencing glucose tolerance in Japanese patients with non-alcoholic fatty liver disease

Ohmi Satoko、Ono Masafumi、Takata Hiroshi、Hirano Seiki、Funakoshi Shogo、Nishi Yuichi、Yoshimura Kumiko、Amano Eri、Terada Yoshio、Saibara Toshiji、Fujimoto Shimpei 2017

[雑誌論文] Prevalence of pruritus in patients with chronic liver disease: A multicenter study

Oeda S, Ono M, Saibara T, Eguchi Y(他16名) 2017

[雑誌論文] 非アルコール性脂肪肝炎を来す薬剤

宮村充彦,横田淳子,西原利治 2016

[学会発表] PNPLA3 IS INVOLVED IN HEPATIC LIPIDS METABOLISM THROUGH XBP1 AND MODUALATION OF ENDOPLASMIC RETICULUM SYRESS IN MICE.

Ono M,Ochi T,Munegage K,Ogasawara M,Hirose A,Nozaki-Fujimura Y,Okamoto N, Iwasaki S,Oben J,Saibara T 2016

[学会発表] NASHの肝線維化進展におけるAGE-RAGE系の関与について.

宗景玄祐,小野正文,西原利治 2016

[雑誌論文] Are genetic variations the most important risk factors for development of hepatocellular carcinoma?

Ono M,Saibara T 2016

[学会発表] POTASSIUM-COMPETITIVE ACID BLOCKER-BASED THIRD-LINE TRIPLE THERAPY IN HELICOBACTER PY-LORI ERADICATION AND STUDY OF THE DIVERSITY OF ANTIMICROBIAL SUSCEPTIBILITIES.

Yano Y,Mizuta H,Kira M,Matsumura Y,Kitagawa T,Hashiba M,Okamoto N,Takeuchi H,Ono M,Saibara T 2016

[学会発表] INVOLVEMENT OF AGE-RAGE SYSTEM FOR THE DEVEL-OPMENT OF HEPATIC FIBROSIS IN NASH.

Munegage K,Ono M,Ochi T,Ogasawara M,Hirose A,Fujimura Y ,Iwasaki S,Saibara T 2016

[学会発表] NAFLD患者の肝線維化進展抑制には早期からの高インスリン血症,血糖変動,DM発症抑制への対策が重要である

宗景玄祐,小野正文,西原利治 2016

[雑誌論文] 診断の進め方:専門医への紹介のポイント

小野正文,西原利治 2016

[雑誌論文] 脂肪肝を防ぐ食生活と治療を考える

西原利治 2016

[雑誌論文] Magnetic Resonance Imaging More Accurately Classifies Steatosis and Fibrosis in Nonalcoholic Fatty Liver Disease Than Transient Elastography.

Imajo K, Kessoku T, Honda Y, Tomeno W, Ogawa Y, Mawatari H, Fujita K, Yoneda M, Taguri M, Hyogo H, Sumida Y, Ono M, Eguchi Y, Inoue T,Yamanaka T, Wada K, Saito S, Nakajima A 2016

[雑誌論文] Suppression of miR-7 biogenesis by NF90-NF45 controls cell proliferation in hepatocellular carcinoma.

Higuchi T, Todaka H, Sugiyama Y, Ono M, Tamaki N, Hatano E, Takezaki Y, Hanazaki K, Miwa T, Chin See LS, Morisawa K, Tsuda M, Taniguchi T, Sakamoto S 2016

[学会発表] EFFICACY OF GLUTATHIONE FOR THE TREATMENT OF NON-ALCOHOLIC FATTY LIVER DISEASE:AN OPEN-LABEL,MULTICENTER,PROSPECTIVE STUDY.

Kessoku T,Sumida Y,Imajo K,Honda Y,Ogawa Y,Yoneda M,Ono M,Egushi,Nakajima A 2016

[学会発表] 非B非C肝がんの発症・予後とアルブミンの関連:Random Forest分析.

川口巧,小野正文,鳥村拓司 2016

[雑誌論文] PNPLA3 is involved in hepatic fatty acid and triglyceride metabolism through XBP1 and modulation of endoplasmic reticulum stress in mice.

Ochi T, Munekage K, Ono M, Higuchi T, Tsuda M, Hayashi Y, Okamoto N, Toda K, Sakamoto S, Oben JA, Saibara T 2016

[雑誌論文] Hepatocellular carcinoma in Japanese patients with nonalcoholic fatty liver disease and alcoholic liver disease: multicenter survey.

Tokushige K, Hyogo H, Nakajima T, Ono M, Kawaguchi T, Honda K, Eguchi Y, Nozaki Y, Kawanaka M, Tanaka S, Imajo K, Sumida Y, Kamada Y, Fujii H, Suzuki Y, Kogiso T, Karino Y, Munekage K, Kuromatsu R, Oeda S, Yanase M, Mori K, Ogawa Y, Seko Y, Takehara T, Itoh Y, Nakajima A, Kanemasa K, Saibara T 2016

[雑誌論文] 肝臓における糖代謝の最新知見

小野正文,越智経浩,西原利治 2015

[雑誌論文] NAFLD、NASHの発症頻度はどれくらい?男女別および国内外の頻度について

小野正文,西原利治 2015

[学会発表] A novel noninvasive diagnostic method for nonalcoholic steatohepatitis(NASH) using two glycobiomarkers.

Kamada Y,Ono M,Hyogo H,Fujii H,Sumida Y,Mori K,Tanaka S,Yamada M,Akita M,Mizutani K,Fujii H,Yamamoto A,Takamatsu S,Yoshida Y,Itoh Y,Kawada N,Chayama K,Saibara T,Takehara T,Miyoshi E 2015

[雑誌論文] NASHはどれくらい存在するのか

越智経浩,小野正文,西原利治 2015

[雑誌論文] NASH/NAFLDおよび肥満研究の最前線

小野正文,西原利治 2015

[学会発表] 糖尿病発症前NAFLD患者の肝線維化進展に寄与する因子の解析-男女別の比較検討より

久家直子,小野正文,増田弘誠,宗景玄祐,越智経浩,西原利治 2015

[雑誌論文] Biphasic effect of alcohol intake on the development of fatty liver disease.

Takahashi H, Ono M, Ono N, Eguchi T, Fujimoto K, Chayama K, Saibara T, Anzai K, Eguchi Y 2015

[学会発表] 高インスリン血症は糖尿病未発症NAFLD患者の肝線維化進展に重要な因子である

宗景玄祐,小野正文,西原利治 2015

[学会発表] C型慢性肝炎患者とNAFLD患者の血糖日中変動に影響を及ぼす要因についての比較検討.

越智経浩,小野正文,西原利治 2015

[雑誌論文] 尿酸血症と非アルコール性脂肪性肝疾患(NAFLD・NASH)

西原利治 2015

[学会発表] 脂肪肝発症に対する性差の影響について-多施設検診受診者の解析より-

黒川早紀,宗景玄祐,越智経浩,高橋宏和,兵庫秀幸,小野正文,江口有一郎,西原利治 2015

[雑誌論文] Evidence-based clinical practice guidelines for nonalcoholic fatty liver disease/nonalcoholic steatohepatitis.

Watanabe S, Hashimoto E, Ikejima K, Uto H, Ono M, Sumida Y, Seike M, Takei Y, Takehara T, Tokushige K, Nakajima A, Yoneda M, Saibara T, Shiota G, Sakaida I, Nakamuta M, Mizuta T, Tsubouchi H, Sugano K, Shimosegawa T; Japanese Society of Gastroenterology; Japan Society of Hepatology. 2015

[雑誌論文] Is nonalcoholic fatty liver disease a systemic disease that promotes extrahepatic cancer development?

Ono M 2015

[学会発表] Risk factors for hepatocellular carcinoma recurrence in patients with nonalcoholic and alcoholic fatty liver disease:A Japanese multicenter survey.

Kogiso T,Hashimoto E,Hyogo H,Nakajima T,Ono M,Kawaguchi T,Honda K,Eguchi Y,Nozaki Y,Kawanaka M,Imajo K,Sumida Y,Kamada Y,Fujii H,Suzuki Y,Tokushige K 2015

[学会発表] PNPLA3遺伝子はER stressを介したapoptosisに関与する.

越智経浩,宗景玄祐,小野正文 2015