研究成果

[雑誌論文] A novel S-sulfhydrated human serum albumin preparation suppresses melanin synthesis,

Ikeda M, Ishima Y, Kinoshita R, Chuang VTG, Tasaka N, Matsuo N, Watanabe H, Shimizu T, Ishida T, Otagiri M, Maruyama T, 2018

[雑誌論文] Dual therapeutic effects of an albumin-based nitric oxide donor on two experimental models of chronic kidney disease

Oshiro S, Ishima Y, Maeda H, Honda N, Bi J, Kinoshita R, Ikeda M, Iwao Y, Imafuku T, Nishida K, Miyamura S, Watanabe H, Otagiri M, Maruyama T 2018

[雑誌論文] Potential therapeutic interventions for chronic kidney disease-associated sarcopenia via indoxyl sulfate-induced mitochondrial dysfunction

Enoki Y, Watanabe H, Arake R, Fujimura R, Ishiodori K, , Imafuku T, Nishida T, Sugimoto R, Nagao S, Miyamura S, Ishima Y, Tanaka M, Matsushita K, Komaba H, Fukagawa M, Otagiri M, Maruyama T 2017

[雑誌論文] The down-regulation of ABCG2, a urate exporter, by parathyroid hormone enhances urate accumulation in secondary hyperparathyroidism

Sugimoto R, Watanabe H, Ikegami K, Enoki Y, Imafuku T, Sakaguchi Y, Murata M, Nishida K, Miyamura S, Ishima Y, Tanaka M, Matsushita K, Komaba H, Fukagawa M, Otagiri M, Maruyama T. 2017

[雑誌論文] Indoxyl sulfate potentiates skeletal muscle atrophy by inducing the oxidative stress-mediated expression of myostatin and atrogin-1

Enoki Y, Watanabe H, Arake R, Sugimoto R, Imafuku T, Tominaga Y, Ishima Y, Kotani S, Nakajima M, Tanaka M, Matsushita K, Fukagawa M, Otagiri M, Maruyama T 2016

[学会発表] S-Nitrosated human serum albumin dimer as a novel nano EPR enhancer applied to nanotechnology based anticancer drug

Ryo Kinoshita (D2), Yu Ishima, Mayumi Ikeda, Jun Fang, Hiroshi Maeda,Masaki Otagiri, Toru Maruyama 2016

[雑誌論文] Human Serum Albumin Hydropersulfide is a potent reactive oxygen species scavenger in oxidative stress conditions such as chronic kidney disease

Shibata A, Ishima Y, Ikeda M, Sato H, Imafuku T, Chuang VTG, Ouchi Y, Abe T, Watanabe H, Ishida T, Otagiri M, Maruyama T 2016

[学会発表] 遺伝子工学的手法を用いた血中滞留型BMP7の設計と持続的腎保護作用の評価

戸田 翔太、渡邊 博志、異島 優、小田切 優樹、丸山 徹 2015

[雑誌論文] Poly-S-nitrosated human albumin enhances the antitumor and antimetastasis effect of bevacizumab, partly by inhibiting autophagy via the generation of nitric oxide

Ishima Y, Inoue A, Fang J, Kinoshita R, Ikeda M, Watanabe H, Maeda H, Otagiri M, Maruyama T 2015

[学会発表] 腎指向型アルブミン-BMP7ハイブリット体の創製と腎保護効果の検討

戸田 翔太、渡邊 博志、弥永 直樹、濱崎 慶輔、國安 明彦、長谷川 功紀、後藤 久美子、異島 優、小田切 優樹、丸山 徹 2015

[雑誌論文] S-Nitrosated human serum albumin dimer as novel nano EPR enhancer applied to macromolecular anti-tumor drugs such as micelles and liposomes

Kinoshita R, Ishima Y, Ikeda M, Kragh-Hansen U, Fang J, Nakamura H, Chuang VTG, Tanaka R, Maeda H, Kodama A, Watanabe H, Maeda H, Otagiri M, Maruyama T 2015

[学会発表] アルブミン融合技術を利用した血中滞留型チオレドキシンの創製と難治性肺疾患治療への応用

渡邊 博志、田中 遼大、異島 優、Chuang VTG、小田切 優樹、丸山 徹 2015

[雑誌論文] Polythiol-containing, recombinant mannosylated-albumin is a superior CD68+/CD206+ Kupffer cell-targeted nano-antioxidant for the treatment of two acute hepatitis models

Maeda H, Hirata K, Watanabe H, Ishima Y, Chuang VTG, Taguchi K, Inatsu A, Kinoshita M, Tanaka M, Sasaki Y, Otagiri M, Maruyama T 2015

[学会発表] アルブミン融合技術を利用した血中滞留型BMP7の作製と腎線維化抑制作用

渡邊 博志、戸田 翔太、異島 優、小田切 優樹、丸山 徹 2015