トップ研究者を探す肺癌に対する成熟樹状細胞を用いた特異的免疫療法の臨床研究

肺癌に対する成熟樹状細胞を用いた特異的免疫療法の臨床研究

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-15590812
研究種目 基盤研究(C)
研究分野 生物系
医歯薬学
内科系臨床医学
呼吸器内科学
研究機関 徳島大学
代表研究者 西岡 安彦
研究分担者 楊河 宏章
研究期間 開始年月日 2003/4/1
研究期間 終了年度 2005
研究ステータス 完了 (2005/4/1)
配分額(合計) 3,400,000 (直接経費 :3,400,000)
配分額(履歴) 2005年度:1,000,000 (直接経費 :1,000,000)
2004年度:1,100,000 (直接経費 :1,100,000)
2003年度:1,300,000 (直接経費 :1,300,000)
キーワード 肺癌
特異的免疫療法
成熟樹状細胞
MAGE-3
癌ワクチン
OK432
lung cancer
specific immunotherapy
mature dendritic cells
MAGE-3
cancer vaccine
OK-432

研究成果

[雑誌論文] A novel IκB kinase-β inhibitor ameliorates bleomycin-induced pulmonary fibrosis in mice

Inayama M, Nishioka Y (co-first author) 2006

[雑誌論文] A novel IκB kinase-β inhibitor ameliorates bleomycin-induced pulmonary fibrosis in mice

Inayama M, Nishioka Y(co-first author) 2006

[雑誌論文] A Novel IκB kinase-β Inhibitor Ameliorates Bleomycin-induced Pulmonary Fibrosis in Mice.

Inayama M, Nishioka Y (co-first author), Azuma M, Muto S, Aono Y, Makino H, Tani K, Uehara H, Izumi K, Itai A, Sone S. 2006

[雑誌論文] A case of sarcoidosis accompanying squamous cell carcinoma in the mandibular gingiva.

Hanibuchi M, Matsumori Y, Nishioka Y, Sone S. 2005

[雑誌論文] Imatinib as a novel antifibrotic agent in bleomycin-induced pulmonary fibrosis in mice.

Aono Y, Nishioka, Y., Inayama M, Kishi J, Ugai M, Uehara H, Izumi K, Sone, S. 2005

[図書] これだけは知っておきたい癌の免疫化学療法

西岡安彦 2005

[雑誌論文] Induction of HM1.24 peptide-specific cytotoxic T lymphocytes by using peripheral blood stem cell harvests in patients with multiple myeloma.

Jalili A, Ozaki S, Hara T, Shibata H, Hashimoto T, Abe M, Nishioka Y, Matsumoto T. 2005

[雑誌論文] Imatinib is a novel anti-fibrotic agent in bleomycin-induced pulmonary fibrosis in mice

Aono Y, Nishioka Y et al. 2005

[雑誌論文] Transforming growth factor □ stimulates rheumatoid synovial fibroblasts via the type II receptor.

Bira Y, Tani K, Nishioka Y, Miyata J, Sato K, Hayashi A, Nakaya Y, Sone S. 2005

[雑誌論文] 樹状細胞による肺癌の免疫療法

西岡安彦 2005

[雑誌論文] Elevation of macrophage-derived chemokine in eosinophilic pneumonia : a role of alveolar macrophages.

Manabe K, Nishioka Y, Kishi J, Inayama M, Aono Y, Nakamura Y, Ogushi F, Bando H, Tani K, Sone S. 2005

[雑誌論文] 癌治療とサイトカイン

西岡安彦 2005

[雑誌論文] Expression of Toll-Like Receptor 4 on Dendritic Cells is Significant for Anti-Cancer Effect of Dendritic Cell-Based Immunotherapy in Combination with an Active Component of OK-432,a Streptococcal Preparation.

Okamoto M, Furuichi S, Nishioka Y, Oshikawa T, Tano T, Uddin A, Takeda K, Akira S, Ryoma Y, Moriya Y, Saito M, Sone S, Sato M. 2004

[雑誌論文] Synthesis and Secretion of Interleukin-15 by Freshly Isolated Human Bronchial Epithelial Cells

Ge N, Nishioka Y et al. 2004

[雑誌論文] Synthesis and Secretion of Interleukin-15 by Freshly Isolated Human Bronchial Epithelial Cells.

Ge N, Nishioka Y, Nakamura Y, Okano Y, Yoneda K, Ogawa H, Sugita A, Yanagawa H, Sone S. 2004

[雑誌論文] 第3次対がん10か年総合戦略、7.免疫療法の現状と展望

西岡安彦 2004

[雑誌論文] Expression of Toll-Like Receptor 4 on Dendritic Cells is Significant for Anti-Cancer Effect of Dendritic Cell-Based Immunotherapy in Combination with an Active Component of OK-432, a Streptococcal Preparation.

Okamoto M, Nishioka Y et al. 2004

[雑誌論文] Adenoviral interleukin-12 gene transduction into human bronchial epithelial cells : up-regulation of pro-inflammatory cytokines and its prevention by corticosteroids.

Ogawa H, Nishimura N, Nishioka Y, Azuma M, Yanagawa H, Sone S. 2003

[雑誌論文] Increased macrophage inflammatory protein-1alpha and -1beta in BAL fluid of bronchiolitis obliterans organizing pneumonia.

Asano T, Ogushi F, Tani K, Tamiya H, Nishioka Y, Sone S. 2003

[雑誌論文] Differential effects of IL-12 on the generation of alloreactive CTL mediated by murine and human dendritic cells : A critical role for nitric oxide.

Nishioka Y 2003

[雑誌論文] Increased Binding and Chemotactic Capacities of PDGF-BB on Fibroblasts in Radiation Pneumonitis.

Tada H, Ogushi F, Tani K, Nishioka Y, Miyata JY, Sato K, Asano T, Sone S. 2003

[図書] ダイナミックメディシン4

西岡安彦 2003

[雑誌論文] Differential effects of IL-12 on the generation of alloreactive CTL mediated by murine and human dendritic cells : A critical role for nitric oxide.

Nishioka Y, Wen H, Mitani K, Robbins PD, Lotze MT, Sone S, Tahara H. 2003

[雑誌論文] Soluble Fas in malignant pleural effusion and its expression in lung cancer cells.

Mitani K, Nishioka Y, Yamabe K, Ogawa H, Miki T, Yanagawa H, Sone S. 2003

[雑誌論文] 難治性固形癌に対する癌抗原ペプチドパルス樹状細胞を用いた癌ワクチン療法-トランスレーショナルリサーチとしての展開-

西岡安彦 2003

[雑誌論文] Molecular mechanisms of angiogenesis in non-small cell lung cancer, and therapeutics targeting related molecules.

Yano S, Nishioka Y, Goto H, Sone S. 2003

職務発明

職務発明