トップ›研究者を探す›血管緊張と増殖制御機構の解明:蛋白質を無傷で細胞内導入する新しい方法の確立と応用

血管緊張と増殖制御機構の解明:蛋白質を無傷で細胞内導入する新しい方法の確立と応用

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-15590758
研究種目 基盤研究(C)
研究分野 生物系
医歯薬学
内科系臨床医学
循環器内科学
研究機関 九州大学
代表研究者 平野 勝也
研究期間 開始年月日 2003/4/1
研究期間 終了年度 2004
研究ステータス 完了 (2004/4/1)
配分額（合計） 3,500,000 (直接経費 :3,500,000)
配分額（履歴） 2004年度：1,700,000 (直接経費 :1,700,000)
2003年度：1,800,000 (直接経費 :1,800,000)
キーワード 蛋白質導入
血管平滑筋
血管内皮細胞
一酸化窒素
トロンビン受容体
アポトーシス
細胞周期
血管緊張
タンパク質
血管
平滑筋
内皮細胞
収縮
組換えDNA
脱リン酸化酵素
protein transduction
vascular smooth muscle cells
vascular endothelial cells
nitric oxide
thrombin receptor
apoptosis
cell cycle
vascular tone

研究成果

[雑誌論文] A critical period requiring Rho proteins for cell cycle progression uncovered by reversible protein transduction in endothelial cells.

Hirano K, Hirano M, Nishimura J, Kanaide H. 2004

[雑誌論文] Akt plays a central role in the anti-apoptotic effect of estrogen in endothelial cells

Koga M, Hirano K, Hirano M, Nishimura J, Kanaide H 2004

[雑誌論文] Akt plays a central role in the anti-apoptotic effect of estrogen in endothelial cells

Koga M, Hirano K, Hirano M, Nishimura J, Kanaide H. 2004

[雑誌論文] Transduction of the N-terminal fragments of MYPT1 enhances myofilament Ca^<2+> sensitivity in an intact coronary artery

Hirano K, Derkach DN, Hirano M, Nishimura J, Takahashi S, Kanaide H 2004

[雑誌論文] A critical period requiring Rho proteins for cell cycle progression uncovered by reversible protein transduction in endothelial cells

Hirano K, Hirano M, Nishimura J, Kanaide H 2004

[雑誌論文] Transduction of the N-terminal fragments of MYPT1 enhances myofilament Ca^<2+> sensitivity in an intact coronary artery

Hirano K, Derkach DN, Hirano M, Nishimura J, Takahashi S, Kanaide H. 2004

[雑誌論文] Facilitation of proteasomal degradation of p27^<Kip1> by N-terminal cleavage,

Hirano K, Ihara E, Hirano M, Nishimura J, Nawata H, Kanaide H 2004

[雑誌論文] Protein kinase network in the regulation of phosphorylation and dephosphoryla tion of smooth muscle myosin light chain (Review article)

Hirano K, Derkach DN, Hirano M, Nishimura J, Kanaide H. 2003

[雑誌論文] Protein kinase network in the regulation of phosphorylation and dephosphorylation of smooth muscle myosin light chain(Review article)

Hirano K, Derkach DN, Hirano M, Nishimura J, Kanaide H 2003

[雑誌論文] Protein kinase network in the regulation of phosphorylation and dephosphorylation of smooth muscle myosin light chain (Review article)

Hirano K, Derkach DN, Hirano M, Nishimura J, Kanaide H 2003

[雑誌論文] Long-term inhibition of RhoA attenuates vascular contractility by enhancing endothelial NO production in an intact rabbit mesenteric artery.

Shiga N, Hirano K, Hirano M, Nishimura J, Nawata H, Kanaide H.

[雑誌論文] Rac1 regulation of the surface expression of PAR1 and respon siveness to thrombin in vascular smooth muscle cells

Yufu T, Hirano K, Bi D, Hirano M, Nishimura J, Iwamoto Y, Kanaide H.

[雑誌論文] Rac1 regulation of the surface expression of PAR1 and responsiveness to thrombin in vascular smooth muscle cells

Yufu T, Hirano K, Bi D, Hirano M, Nishimura J, Iwamoto Y, Kanaide H.

[雑誌論文] Regulation of myosin phosphorylation and myofilament Ca^<2+> sensitivity in vascular smooth muscle(Review article)

Hirano K, Hirano M, Kanaide K

[雑誌論文] Long-term inhibition of RhoA attenuates vascular contractility by enhancing endothelial NO production in an intact rabbit mesenteric artery

Shiga N, Hirano K, Hirano M, Nishimura J, Nawata H, Kanaide H.