トップ›研究者を探す›サルモネラのTypeIII病原蛋白分泌システムの機能解析

サルモネラのTypeIII病原蛋白分泌システムの機能解析

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-15590055
研究種目 基盤研究(C)
研究分野 生物系
医歯薬学
薬学
生物系薬学
研究機関 千葉大学
代表研究者 友安 俊文
研究分担者 山本 友子
研究分担者 高屋 明子
研究期間 開始年月日 2003/4/1
研究期間 終了年度 2004
研究ステータス 完了 (2004/4/1)
配分額（合計） 3,600,000 (直接経費 :3,600,000)
配分額（履歴） 2004年度：1,700,000 (直接経費 :1,700,000)
2003年度：1,900,000 (直接経費 :1,900,000)
キーワード サルモネラ属細菌
TypeIII分泌装置
AAA^+プロテアーゼ
シャペロン
Lon
ClpXP
DnaK
病原因子
Salmonella
TTSS
AAA+ protease
chaperone
Lon
ClpXP
DnaK
Dathogenic factor

研究成果

[雑誌論文] Derepression of Salmonella pathogenicity island 1 genes within macrophages leads to rapid apoptosis via caspase-1- and caspase-3-dependent pathways.

Takaya A, Suzuki A, Kikuchi Y, Eguchi M, Isogai E, Tomoyasu T, Yamamoto T. 2005

[雑誌論文] Derepression of Salmonella pathogenicity island 1 genes within macrophages leads to rapid apoptosis via caspase-1-and caspase-3-dependent pathways.

Takaya A, Suzuki A, Kikuchi Y, Eguchi M, Isogai E, Tomoyasu T, Yamamoto T. 2005

[雑誌論文] Depression of Salmonella pathogenicity island 1 genes within macrophages leads to rapid apoptosis via caspase-1- and caspase-3-dependent pathways.

Takaya A, Suzuki A, Kikuchi Y, Eguchi M, Isogai E, Tomoyasu T, Yamamoto T. 2005

[雑誌論文] The DnaK/DnaJ Chaperone Machinery of Salmonella enterica Serovar Thyphimurium is Essential for Invasion of Epitherial Cells and Survival within Macrophages, Leading to Systemic infection.

Takaya A, Tomoyasu T, Matsui H, Yamamoto T. 2004

[雑誌論文] The DnaK/DnaJ Chaperone Machinery of Salmonella enterica Serovar Thyphimurium Is Essential for Invasion of Epitherial Cells and Survival within Macrophages, Leading to Systemic infection.

Takaya A, Tomoyasu T, Matsui H, Yamamoto T. 2004

[雑誌論文] The DnaK/DnaJ Chaperone Machinery of Salmonella enterica Serovar Thyphimurium Is Essential for Invasion of Epitherial Cells and Survival within Macrophages, Leading to Systemic infection.

Takaya A, Tomoyasu T, Matsui H, Yamamoto T. 2004

[雑誌論文] A new heat-shock gene agsA, which encodes a small chaperone involved in suppressing protein aggregation in Salmonella entrica serovar Typhimurium.

Tomoyasu T, Takaya A, Sasaki T, Nagase T, Kikuno R, Morioka M, Yamamoto T. 2003

[雑誌論文] Lon, a stress-induced ATP-dependent protease is critically important for the systemic Salmonella infection of mice.

Takaya A, Suzuki M, Matsui H, Tomoyasu T, Sashinami H, Nakane A, Yamamoto T. 2003

[雑誌論文] A new heat-shock gene agsA, which encodes a small chaperone invloved in suppressing protein aggregation in Salmonella entrica serovar Typhimurium.

Tomoyasu T, Takaya A, Sasaki T, Nagase T, Kikuno R, Morioka M, Yamamoto T 2003

[雑誌論文] Turnover of F1hD and F1hC, master regulator proteins for Salmonella flagellum biogenesis, by the ATP-dependent ClpXP protease.

Tomoyasu T, Takaya A, Isogai E, Yamamoto T 2003

[雑誌論文] Turnover of FlhD and FlhC, master regulator proteins for Salmonella flagellum biogenesis, by the ATP-dependent ClpXP protease.

Tomoyasu T, Takaya A, Isogai E, Yamamoto T. 2003

[雑誌論文] Lon, a stress-induced ATP-dependent protease is critically important for the systemic Salmonella infection of mice.

Takaya A, Suzuki M, Matsui H, Tomoyasu T, Sashinami H, Nakane A, Yamamoto T. 2003

[雑誌論文] Oral immunization with ATP-dependeht protease-deficient mutants protects mice against subsequent oral challenge with virulent Salmonella enterica serovar Typhimurium.

Matsui H, Suzuki M, Isshiki Y, Eguchi M, Kikuchi Y, Motokawa K, Takaya A, Tomoyasu T, Yamamoto T. 2003