トップ›研究者を探す›放射線肺臓炎の分子病態に基づく新規治療法の開発

放射線肺臓炎の分子病態に基づく新規治療法の開発

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-15390256
研究種目 基盤研究(B)
研究分野 生物系
医歯薬学
内科系臨床医学
呼吸器内科学
研究機関 徳島大学
代表研究者 曽根 三郎
研究分担者 谷 憲治
研究期間 開始年月日 2003/4/1
研究期間 終了年度 2004
研究ステータス 完了 (2004/4/1)
配分額（合計） 11,800,000 (直接経費 :11,800,000)
配分額（履歴） 2004年度：5,300,000 (直接経費 :5,300,000)
2003年度：6,500,000 (直接経費 :6,500,000)
キーワード 放射線肺臓炎
CD13
Aminopetidase N
肺胞マクロファージ
Bestatin
Aminopeptidase N
radiation pneumonitis
CD13
aminopeptidase N
macrophages
bestatin

研究成果

[雑誌論文] Parathyroid hormone-related protein (PTHRP) is responsible for production of bone metastasis, but not visceral metastasis, by human small cell lung cancer SBC-5 cells in natural killer cell-depleted SCID mice.

Miki T, Sone, S, et al. 2004

[雑誌論文] Ebselen inhibits tumor necrosis factor- α -induced c-Jun N-terminal kinase activation and adhesion molecule expression in endothelial cells.

Yoshizumi M, Sone S, et al. 2004

[雑誌論文] Expression of Toll-Like Receptor 4 on Dendritic Cells is Significant for Anticancer Effect of Dendritic Cell-Based Immunotherapy in Combination with an Active Component of OK-432, a Streptococcal Preparation.

Okamoto M, Sone S, et al. 2004

[雑誌論文] Ebselen inhibits tumor necrosis factor-α-induced c-Jun N-terminal kinase activation and adhesion molecule ・・・

Yoshizumi, M., Sone S, et al. 2004

[雑誌論文] Sensitization of tumor-associated endothelial cell apotosis by the with cisplatin ・・・

Goto H, Sone S, et al. 2004

[雑誌論文] Synthesis and secretion of interleukin-15 by freshly isolated human bronchial epithelial cells ・・・

Ge N, Sone S, et al. 2004

[雑誌論文] Parathyroid hormone-related protein is responsible for production of bone metastasis ・・・

Miki T, Sone S, et al. 2004

[雑誌論文] Expression of toll-like receptor 4 on dendritic cells is significiant for anticancer effect of dendritic cell-based ・・・

Okamoto M, Sone S, et al. 2004

[雑誌論文] Stimulation of human bronchial epithelial cells by IgE-dependent histamine-releasing factor ・・・

Yoneda K, Sone S, et al. 2004

[雑誌論文] Multifunctional interleukin-1 β promotes metastasis of human lung cancer cells in SCID mice via enhanced expression of adhesion-, invasion- and angiogenesis-related molecules.

Yano S, Sone, S, et al. 2003

[雑誌論文] Combined therapy with a new bisphosphonate, minodronate and chemotherapy for multiple organ metastasis of small cell lung cancer cells in severe combined immunodeficient mice.

Yano S, Sone S et al. 2003

[雑誌論文] A novel bisphosphonate minodronate (YM529) specifically inhibits osteolytic bone metastasis produced by human small-cell lung cancer cells in NK-cell depleted SCID mice.

Zhang H, Sone S, et al. 2003

[雑誌論文] Genome-wide analysis of organ preferential metastasis of human small cell lung cancer in mice.

Kakiuchi S, Sone S, et al. 2003

[雑誌論文] Differential effects of IL-2 on the generation of alloreactive CTL mediated by murine and human dendritic cells.

Nishioka Y, Sone S, et al. 2003

[雑誌論文] Molecular mechanisms of angiogenesis in non-small cell lung cancer, and therapeutics targeting related molecules.

Yano S, Sone S, et al. 2003

[雑誌論文] Increased macrophage inflammatory protein-1 α and -1 β in BAL fluid of bronchiolitis obliterans organizing pneumonia.

Asano T, Tani K, Sone S, et al. 2003