トップ研究者を探すCGHアレイ法によるゲノム異常解析に基づく口腔癌の悪性度予測と治療標的分子の探索

CGHアレイ法によるゲノム異常解析に基づく口腔癌の悪性度予測と治療標的分子の探索

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-15209069
研究種目 基盤研究(A)
研究分野 生物系
医歯薬学
歯学
外科系歯学
研究機関 東京医科歯科大学
代表研究者 天笠 光雄
研究分担者 稲澤 譲治
研究分担者 鵜沢 成一
研究分担者 井本 逸勢
研究期間 開始年月日 2003/4/1
研究期間 終了年度 2005
研究ステータス 完了 (2005/4/1)
配分額(合計) 43,940,000 (直接経費 :33,800,000、間接経費 :10,140,000)
配分額(履歴) 2005年度:4,810,000 (直接経費 :3,700,000、間接経費 :1,110,000)
2004年度:13,520,000 (直接経費 :10,400,000、間接経費 :3,120,000)
2003年度:25,610,000 (直接経費 :19,700,000、間接経費 :5,910,000)
キーワード 口腔癌
CGHアレイ
ゲノム
分子標的
DNAメチル化
Oral cancer
Array-CGH
Genome
Molecular target
DNA methylation

研究成果

[雑誌論文] Screening of DNA copy-number aberrations in gastric cancer cell lines by array-based comparative genomic hybridization.

Takada H., Imoto I., Tsuda H., Inazawa J, et al. 2005

[雑誌論文] Genetic classification of lung adenocarcinoma based on array-based comparative genomic hybridization analysis : its association with clinicopathologic features.

Shibata T., Uryu S., Kokubu A., Hosoda F., Ohki M., Sakiyama T., Matsuno Y., suchiya R., Kanai Y., Kondo T., Imoto I., Inazawa J., Hirohashi S 2005

[雑誌論文] The clinical significance of Aurora-A/STK15/BTAK expression in human esophageal squamous cell carcinoma.

Tanaka E., Hashimoto Y., Ito T., Okumura T., Kan T., Watanabe G., Imamura M., Inazawa J., Shimada Y 2005

[雑誌論文] Genetic profile of hepatocellular carcinoma revealed by array-based comparative genomic hybridization : Identification of genetic indicators to predict patient outcome.

Katoh H., Shibata T., Kokubo A., Ojima H., Loukopoulos P., Kanai Y., Kosuge T., Fukayama M., Kondo T., Sakamoto M., Hosoda F., Ohki M., Imoto I., Inazawa J., Hirohashi S 2005

[雑誌論文] Nuclear expression of cIAP-1, an apoptosis inhibiting protein, predicts lymph node metastasis and poor patient prognosis in head and neck squamous cell carcinomas.

Tanimoto T., Tsuda H., Inazawa J, et al. 2005

[雑誌論文] Array-based comparative genomic hybridization analysis of high-grade neuroendocrine tumors of the lung.

Peng WX., Shibata T., Katoh H., Kokubu A., Matsuno Y., Asamura H., Tsuchiya R., Kanai Y., Hosoda F., Sakiyama T., Ohki M., Imoto I., Inazawa J., Hirohashi S 2005

[雑誌論文] Methylation-associated silencing of the nuclear receptor 1I2 gene in advanced-type neuroblastomas, identified by bacterial artificial chromosome array-based methylated CpG island amplification.

Misawa A, Imoto I, Inazawa J, et al. 2005

[雑誌論文] Involvement of cyclin D3 in liver metastasis of colorectal cancer, revealed by genome-wide copy-number analysis.

Tanami H, Imoto I, Inazawa J, et al. 2005

[雑誌論文] Methylation-associated silencing of the nuclear receptor 112 gene in advanced-type neuroblastomas, identified by bacterial artificial chromosome array-based methylated CpG island amplification.

Misawa A., Inoue J., Sugino Y., Hosoi H., Sugimoto T., Hosoda F., Ohki M., Imoto I., Inazawa J 2005

[雑誌論文] Involvement of cyclin D3 in liver metastasis of colorectal cancer, revealed by genome-wide copy-number analysis.

Tanami H., Tsuda H., Okabe S., Iwai T., Sugihara K., Imoto I., Inazawa J 2005

[雑誌論文] Frequent silencing of DBC1 is by genetic or epigenetic mechanisms in non-small cell lung cancers.

Izumi H., Inoue J., Yokoi S., Hosoda H., Shibata T., Sunamori M., Hirohashi S., Inazawa J., Imoto I 2005

[雑誌論文] Poly (ethylene glycol) hydrogels cross-linked by hydrolyzable polyrotaxane containing hydrozyapatite particles as scaffolds for bone regeneration.

Fujimoto M., Isobe M., Yamaguchi S., Amagasa T, et al. 2005

[雑誌論文] Overexpressed Skp2 within 5p amplification detected by array-based comparative genomic hybridization is associated with poor prognosis of glioblastomas.

Saigusa K., Hashimoto N., Inazawa J, et al. 2005

[雑誌論文] Screening of DNA copy-number aberrations in gastric cancer cell lines by array-based comparative genomic hybridization.

Takada H., Imoto I., Tsuda H., Sonoda I., chikura T., Mochizuki H., Okanoue T., Inazawa J 2005

[雑誌論文] ADAM23, a possible tumor suppressor gene, is frequently silenced in gastric cancers by homozygous deletion or aberrant promoter hypermethylation.

Takada H., Imoto I., Inazawa J, et al. 2005

[雑誌論文] Overexpressed Skp2 within 5p amplification detected by array-based comparative genomic hybridization is associated with poor prognosis of glioblastomas.

Saigusa K., Hashimoto N., Tsuda H., Yokoi S., Maruno M., Yoshimine T., Aoyagi M., Ohno K., Imoto I., Inazawa J 2005

[雑誌論文] Array-based comparative genomic hybridization analysis of high-grade neuroendocrine tumors of the lung.

Peng WX, Shibata T., Katoh H., Imoto I., Inazawa J., et al. 2005

[雑誌論文] The clinical significance of Aurora-A/STK15/BTAK expression in human esophageal squamous cell carcinoma.

Tanaka E., Hashimoto Y., Inazawa J., et al. 2005

[雑誌論文] Detection of cryptic chromosome aberrations in a patient with a balanced t(1;9)(p34.2;p24) by array-based comparative genomic hybridization.

Hayashi S., Kurosawa K., Imoto I., Mizutani S., Inazawa J 2005

[雑誌論文] Poly (ethylene glycol) hydrogels cross-linked by hydrolyzable polyrotaxane containing hydroxyapatite particles as scaffolds for bone regeneration.

Fujimoto M., Isobe M., Yamaguchi S., Amagasa T., Watanabe A., Ooya T, Yui N 2005

[雑誌論文] Nuclear expression of clAP-1, an apoptosis inhibiting protein, predicts lymph node metastasis and poor patient prognosis in head and neck squamous cell carcinomas.

Tanimoto T., Tsuda H., Imazeki N., Ohno Y., Imoto I., Inazawa J., Matsubara O 2005

[雑誌論文] Frequent silencing of DBC1 is by genetic or epigenetic mechanisms in non-small cell lung cancers.

Izumi H, Imoto I, Inazawa J, et al. 2005

[雑誌論文] ADAM23, a possible tumor suppressor gene, is frequently silenced in gastric cancers by homozygous deletion or aberrant promoter hypermethylation.

Takada H., Imoto I., Tsuda H., Nakanishi Y., Ichikura T., Mochizuki H., Mitsufuji S., Hosoda F., Hirohashi S., Ohki M., Inazawa J 2005

[雑誌論文] Establishment of a cell line from a malignant rhabdoid tumor of the liver lacking the function of two tumor suppressor genes, hSNF5/INI1 and p16.

Kuroda H., Moritake H., Sawada K., Kuwahara Y., Imoto I., Inazawa J., Sugimoto T 2005

[雑誌論文] Alteration in copy numbers of genes as a mechanism for acquired drug resistance.

Yasui K., Mihara S., Zhao C., Okamoto H., Saito-Ohara F., Tomida A., Funato T., Yokomizo A., Naito S., Imoto I., Tsuruo T., Inazawa J 2004

[雑誌論文] Frequent silencing of low density lipoprotein Receptor-Related Protein 1B (LRP1B) expression by genetic and epigenetic mechanisms in esophageal squamous cell carcinoma.

Sonoda I., Imoto I., Shibata T., Shimada Y., Chin K., Imamura M., Amagasa T., J.W.Gray., Hirohashi S., Inazawa J. 2004

[雑誌論文] Involvement of overexpressed wild-type BRAF in the growth of malignant melanoma cell lines.

Tanami H., Imoto I., Hirasawa A., Inazawa J, et al. 2004

[雑誌論文] Translocation (1;22)(p36;q11.2) with concurrent del(22)(q11.2) resulted in homozygous deletion of SNF5/INI1 in a newly established cell line derived from extrarenal rhabdoid tumor.

Misawa A., Hosoi H., Imoto I., Iehara T., Sugimoto T., Inazawa J 2004

[雑誌論文] Mutations in EFHC1 cause juvenile myoclonic epilepsy.

Suzuki T., Delgado-Escueta AV., Aguan K., Alonso ME., Shi J., Hara Y., Nishida M., Numata T., Medina MT., Takeuchi T., Morita R., Bai D., Ganesh S., Sugimoto Y., Inazawa J., Bailey JN., Ochoa A., Jara-Prado A., Rasmussen A., Ramos-Peek J., Cordova S., Rubio-Donnadieu F., Inoue Y., Osawa M., Kaneko S., Oguni H., Mori Y., Yamakawa K 2004

[雑誌論文] Skp2 overexpression is a p27Kip1-independent poor prognosticator in patients with biliary tract cancers.

Sanada T., Yokoi S., Arii S., Yasui K., Imoto I., Inazawa J 2004

[雑誌論文] Identification of a novel fusion gene in a pre-B acute lymphoblastic leukemia with t(1;19)(q23;p13).

Yuki Y., Imoto I., Imaizumi M., Hibi S., Kaneko Y., Amagasa T., Inazawa J. 2004

[雑誌論文] Overexpression of PDZK1 within the 1q12-q22 amplicon is likely to be associated with drug-resistance phenotype in multiple myeloma.

Inoue J., Otsuki T., Hirasawa A., Imoto I., Matsuo Y., Shimizu S., Taniwaki M., Inazawa J 2004

[雑誌論文] Involvement of overexpressed wild-type BRAF in the growth of malignant melanoma cell lines.

Tanami H., Imoto I., Hirasawa A., Yuki Y., Sonoda I., Inoue J., Yasui K., Misawa-Furihata A., Kawakami Y., Inazawa J 2004

[雑誌論文] Frequent silencing of low density lipoprotein Receptor-Related Protein 1B(LRP1B) expression by genetic and epigenetic mechanisms in esophageal squamous cell carcinoma.

Sonoda I., Imoto I., Amagasa T., Inazawa J., et al. 2004

[雑誌論文] Identification of a novel fusion gene in a pre-B acute lymphoblastic leukemia with t (1;19)(q23;p13).

Yuki Y., Imoto I., Amagasa T., Inazawa J., et al. 2004

[雑誌論文] Identification of a novel fusion gene in a pre-B acute lymphoblastic leukemia with t(1;19)(q23;p13).

Yuki Y, Imoto I, Inazawa J, et al. 2004

[雑誌論文] Comparative genomic hybridization (CGH) arrays pave the way for identification of novel cancer-related genes.

Inazawa J., Inoue J., Imoto I 2004

[雑誌論文] Pigmented villonodular synovitis of the temporomandibular joint : differential diagnosis and case report.

Aoyama S., Iwaki H., Amagasa T., Kino K., Okada N., Kishimoto S. 2004

[雑誌論文] Frequent silencing of low density lipoprotein receptor-related protein 1B (LRP1B) expression by genetic and epigenetic mechanisms in esophageal squamous cell carcinoma.

Sonoda I, Imoto I, Inazawa J, et al. 2004

[雑誌論文] Identification of ZASC1ageal squamous cell carcinomas.

Imoto I., Yuki Y., Sonoda I., Ito T., Shimada Y., Imamura M., Inazawa J 2003

[雑誌論文] TERC identified as a probable target within the 3q26 amplicon that is detected frequently in non-small cell lung cancers.

Yokoi S., Yasui K., Iizasa T., Imoto I., Fujisawa T., Inazawa J 2003

[雑誌論文] Correlation between genetic alteration and long-term clinical outcome of patients with oligodendroglial tumors, with identification of a consistent region of deletion on chromosome arm 1p.

Hashimoto N., Murakami M., Inazawa J, et al. 2003

[雑誌論文] PPMID is a potential target for 17q gain in neuroblastoma.

Saito-Ohara F., Imoto I., Inoue I., Hosoi H., Nakagawara A., Sugimoto T., Inazawa J 2003

[雑誌論文] Correlation between genetic alteration and long-term clinical outcome of patients with oligodendroglial tumors., with identification of a consistent region of deletion on chromosome arm 1p.

Hashimoto N., Murakami M., Takahashi Y., Fujimoto M., Inazawa J., Mineura K 2003

[雑誌論文] PPM1D is a potential target for 17q gain in neuroblastoma.

Saito-Ohara F., Imoto I., Inazawa J, et al. 2003

[雑誌論文] Neck node metastasis after successful brachytherapy for early stage tongue carcinoma.

Nakagawa T., Sibuya H., Yoshimura R., Miura M., Okada N., Kishimoto S., Amagasa T., Omura K 2003

[雑誌論文] Cell culture in esophageal squamous cell carcinoma and the association with molecular markers.

Shimada Y., Maeda M., Watanabe G., Yamasaki S., Komoto I., Kagonoi J., Kan T., Hashimoto Y., Imoto I., Inazawa I 2003

[雑誌論文] Physical map and haplotype analysis of 16q-linked autosomal dominant cerebellar ataxia (ADCA) type III in Japan.

Li M., Ishikawa K., Toru S., Tomimitsu H., Takashima M., Goto J., Takiyama Y., Sasaki H., Imoto I., Imazawa J., Toda T., Kanazawa I., Mizusawa H 2003

[雑誌論文] A consistent region of deletion on 1p36 in meningiomas : identification and relation to malignant progression.

Murakami M., Hashimoto N., Takahashi Y., Hosokawa Y., Inazawa J., Minneura K 2003

[雑誌論文] Identification of ZASC1 encoding a Kruppel-like zinc finger protein as a novel target for 3q26 amplification in esophageal squamous cell carcinomas.

Imoto I., Yuki Y., Inazawa J, et al. 2003

[雑誌論文] GPC5 is a possible target for the 13q31-q32 amplification detected in lymphoma cell lines.

Yu W., Inoue J., Imoto I., Matsuo Y., Karpas A., Inazawa J 2003

[雑誌論文] Association of 17q21-q24 gain in ovarian clear cell adenocarcinomas with poor prognosis and identification of PPM1D and APPBP2 as likely amplification targets.

Hirasawa A., Saito-Ohara F., Inoue J., Aoki D., Susumu N., Yokoyama T., Nozawa S., Inazawa J., Imoto I 2003

[雑誌論文] A consistent region of deletion on 1p36 in meningiomas : identification and relation to malignant progression.

Murakami M., Hashimoto N., Inazawa J, et al. 2003

[雑誌論文] Unfavorable prognostic factors associated with high frequency of microsatellite instability and comparative genomic hybridization analysis in endometrial cancer.

Hirasawa A., Aoki D., Inoue J., Imoto I., Susumu N., Sugano K., Nozawa S., Inazawa J 2003