トップ›研究者を探す›エネルギー代謝と細胞死の制御におけるミトコンドリアタンパク質の役割

エネルギー代謝と細胞死の制御におけるミトコンドリアタンパク質の役割

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-14370746
研究種目 基盤研究(B)
研究分野 医学
薬学
生物系薬学
研究機関 徳島大学
代表研究者 篠原 康雄
研究分担者 山崎 尚志
研究分担者 寺田 弘
研究期間 開始年月日 2002/4/1
研究期間 終了年度 2005
研究ステータス 完了 (2005/4/1)
配分額（合計） 13,800,000 (直接経費 :13,800,000)
配分額（履歴） 2005年度：2,500,000 (直接経費 :2,500,000)
2004年度：2,500,000 (直接経費 :2,500,000)
2003年度：2,500,000 (直接経費 :2,500,000)
2002年度：6,300,000 (直接経費 :6,300,000)
キーワード ミトコンドリア
細胞死
透過性遷移
シトクロムc
プロテオミクス解析
エネルギー代謝
酵母
酸化的リン酸化
遺伝子壊変酵母
エネルギー変換
アポトーシス
mitochondria
apoptosis
permeability transition
cytochrome c
proteomics analysis
energy conversion
Yeast

研究成果

[雑誌論文] Essential role of citrate export from mitochondria at early differentiation stage of 3T3-L1 cells for their effective differentiation into fat cells, as revealed by studies using specific inhibitors of mitochondrial di- and tricarbodylate carriers

K.Kajimoto, H.Terada, Y.Baba, Y.Shinohara 2005

[雑誌論文] Molecular basis of the morphological changes of mitochondrial membrane accompanies with induction of permeability transition as revealed by studies using immuno-electron microscopy

S.Terauchi, T.Yamamoto, K.Yamashita, M.Kataoka, H.Terada, Y.Shinohara 2005

[雑誌論文] Cysteine labeling studies detect conformational changes in region 106-132 of the mitochondrial ADP/ATP carrier of Saccharomyces cerevisiae

Y.Kihira, E.Majima, Y.Shinohara, H.Terada 2005

[雑誌論文] Analysis of mitochondrial membrane potential in the cells by microchip flow cytometry

M.Kataoka, Y.Fukura, Y.Shinohara, Y.Baba 2005

[雑誌論文] Analysis of mitochondrial membrane potential in the cells by microchip flow cytometry.

M.Kataoka, Y.Fukura, Y.Shinohara, Y.Baba 2005

[雑誌論文] Essential role of citrate export from mitochondria at early differentiation stage of 3T3-L1 cells for their effective differentiation into fat cells, as revealed by studies using specific inhibitors of mitochondrial di- and tricarbodylate carriers

K.Kajimoto, H.Terada, Y.Baba, Y.Shinohara 2005

[雑誌論文] Two critical factors affecting the release of mitochondrial cytochrome c as revealed by studies using N, N'-dicyclohexylcarbodiimide as an atypical inducer of permeability transition

T.Yamamoto, S.Terauchi, A.Tachikawa, K.Yamashita, M.Kataoka, H.Terada, Y.Shinohara 2005

[雑誌論文] Drug-induced gingival overgrowth-a review

M.Kataoka, J.Kido, Y.Shinohara, T.Nagata 2005

[雑誌論文] Drug-induced gingival overgrowth - a review

M.Kataoka, J.Kido, Y.Shinohara, T.Nagata 2005

[雑誌論文] Molecular basis of the morphological changes of mitochondrial membrane accompanied with induction of permeability transition as revealed by studies using immuno-electron microscopy

S.Terauchi, T.Yamamoto, K.Yamashita, M.Kataoka, H.Terada, Y.Shinohara 2005

[雑誌論文] Mitochondrial delivery of mastoparan with transferrin liposomes equipped with a pH-sensitive fusogenic peptide for selective cancer therapy

Y.Yamada, Y.Shinohara, T.Kakudo, S.Chaki, S.Futaki, H.Kamiya, H.Harashima 2005

[雑誌論文] Comparison of gene expression profiles between white and brown adipose tissues of rat by microarray analysis

Unami, Y.Shinohara, K.Kajimoto, Y.Baba 2004

[雑誌論文] Twisting of the second transmembrane alpha-helix of the mitochondrial ADP/ATP carrier during transition between 2 carrier conformational states

Y.Kihira, A.Iwahashi, E.Majima, H.Terada, Y.Shinohara 2004

[雑誌論文] Usefulness of microchip electrophoresis for reliable analyses of non-satndard DNA samples and subsequent on-chip enzymatic digestion.

M.Kataoka, S.Inoue, K.Kajimoto, Y.Shinohara, Y.Baba 2004

[雑誌論文] Comparison of gene expression profiles between white and brown adipose tissues of rat by microarray analysis

Unami, Y.Shinohara, K.Kajimoto, Y.Baba 2004

[雑誌論文] Usefulness of microchip electrophoresis for reliable analyses of non-satndard DNA samples and subsequent on-chip enzymatic digestion

M.Kataoka, S.Inoue, K.Kajimoto, Y.Shinohara, Y.Baba 2004

[雑誌論文] Biochemical and microarray analyses of bupivacaine-induced apoptosis.

Unami, Y.Shinohara, T.Ichikawa, Y.Baba 2003

[雑誌論文] Biochemical and microarray analyses of bupivacaine-induced apoptosis.

Unami, Y.Shinohara, T.Ichikawa, Y.Baba 2003

[雑誌論文] 脱共役剤研究の最近の進歩

篠原康雄, 山本武範, 寺田 弘 2003

[雑誌論文] Recent progress in studies on the uncouplers of oxidative phosphorylation

Y.Shinohara, T Yamamoto, H.Terada 2003

[雑誌論文] The gene encoding muscle type carnitine palmitoyltransferase I : comparison of the 5'-upstream region of human and rodent genes

N.Yamazaki et al. 2003

[雑誌論文] The gene encoding muscle type carnitine palmitoyltransferase I : comparison of the 5'-upstream region of human and rodent genes

N.Yamazaki et al. 2003

[雑誌論文] Requirement of continuous transcription for production of certain amount of protein by Rapid Translation System

M.Hino, Y.Shinohara, K.Kajimoto, H.Terada, Y.Baba 2002

[雑誌論文] Permeability transition-independent release of mitochondrial cytochrome c induced by valinomycin

Y.Shinohara et al. 2002

[雑誌論文] Permeability transition-independent release of mitochondrial cytochrome c induced by valinomycin

Y.Shinohara et al. 2002

[雑誌論文] Structural properties of mammalian mitochondrial ADP/ATP carriers

N.Yamazaki, Y.Shinohara, K.Tanida, H.Terada 2002

[雑誌論文] Close location of the first loop to the third loop of the mitochondrial ADP/ATP carrier deduced from cross-linking catalyzed by copper-o-phenanthroline of the solubilized carrier with Triton X-100

E.Majima, M.Takeda, S.Miki, Y.Shinohara, H.Terada 2002

[雑誌論文] Close location of the first loop to the third loop of the mitochondrial ADP/ATP carrier deduced from cross-linking catalyzed by copper-c-phenanthroline of the solubilized carrier with Triton X-100

E.Majima, M.Takeda, S.Miki, Y.Shinohara, H.Terada 2002

[雑誌論文] Cell-free protein synthesis on a microchip

M.Tabuchi, M.Hino, Y.Shinohara, Y.Baba 2002

[雑誌論文] Requirement of continuous transcription for production of certain amount of protein by Rapid Translation System

M.Hino, Y.Shinohara, K.Kajimoto, H.Terada, Y.Baba 2002

薬物の長期服用による歯肉増殖症の発症の危険度を判定するための方法