口腔癌の微小転移機構の解析と分子標的治療による転移阻止

トップ›研究者を探す›口腔癌の微小転移機構の解析と分子標的治療による転移阻止

代表研究者	浜川裕之
研究課題番号	KAKENHI-PROJECT-14207091
研究種目	基盤研究(A)
研究分野	医学歯学外科系歯学
研究機関	愛媛大学
研究分担者	新谷悟
研究分担者	中城公一
研究期間開始年月日	2002/4/1
研究期間終了年度	2004
研究ステータス	完了 (2004/4/1)
配分額（合計）	43,030,000 (直接経費 :33,100,000、間接経費 :9,930,000)
配分額（履歴）	2004年度：5,850,000 (直接経費 :4,500,000、間接経費 :1,350,000) 2003年度：17,940,000 (直接経費 :13,800,000、間接経費 :4,140,000) 2002年度：19,240,000 (直接経費 :14,800,000、間接経費 :4,440,000)
キーワード	口腔癌転移分子標的治療 EGFR CXCR4 VEGF HIF-1 c-Met ZD1839 HGF c-met Stat-3 微小転移術中遺伝子診断リアルタイムPCR COX-2阻害剤浸潤 GFP マイクロアレイ Oral cancer Metastasis Molecular target therapy EGFR CXCR4 VEGF HIF-1 c-Met

研究成果

[雑誌論文] Growth regulated oncogene 1 expression is associated with angiogenesis and lymph node metastasis in human oral cancer.

Shintani S, T.Ishikawa, T.Nonaka, C.Li, K.Nakashiro, D.T.W.Wong, H.Hamakawa 2004

[雑誌論文] Overexpression of cyclooxygenase-2 is associated with radioresistance in oral squamous cell carcinoma

N Terakado, S Shintani, J Yano, C Li, M Mihara, K Nakashiro, Hamakawa H 2004

[雑誌論文] Gefinitib ('Iressa', ZD1839), an eppidermal growth factor receptor tyrosine kinase inhibitor, up-regulates p27KIPl and induces G1 arrest in oral squamous cell carcinoma cell lines.

S Shintani, C Li, M Mihara, J Yano, N Terakado, K Nakashiro, H Hamakawa 2004

[雑誌論文] Basic and clinical studies on quantitative analysis of lymph node micrometastasis in oral cancer.

A Onishi, K Nakashiro, M Mihara, T Sumida, H Kawamata, S Shintani, T Aida, T Tachikawa, H Hamakawa 2004

[雑誌論文] Overexpression of cyclooxygenase-2 is associated with radioresistance in oral squamous cell carcinoma.

N Terakado, S Shintani, J Yano, C Li, M Mihara, K Nakashiro, Hamakawa H 2004

[雑誌論文] HER2/neu expression in oral squamous cell carcinoma.

S Shintani, Y Nakahara, C Li, M Mihara, K Nakashiro, H Hamakawa 2004

[雑誌論文] Skp2 and Jab1 expression are associated with inverse expression of p27KIP1 and poor prognosis in oral squamous cell carcinomas.

S Shintani, C Li, M Mihara, S Hino, K Nakashiro, H Hamakawa 2004

[雑誌論文] Expression of vascular endothelial growth factor-A, B, C, and D in oral squamous cell carcinoma.

S Shintani, C Li, M Mihara, T Isikawa, M Mihara, K Nakashiro, H Hamakawa 2004

[雑誌論文] Phenotypic switch from paracrine to autocrine role of hepatocyte growth factor in an androgen-independent human prostatic carcinoma cell line, CWR22R.

Nakashiro K, Hara S, Shinohara Y, Oyasu M, Kawamata H, Shintani S, Hamakawa H, Oyasu R 2004

[雑誌論文] Expression of vascular endothelial growth factor A,B,C, and D in oral squamous cell carcinoma

S Shintani, C Li, M Mihara, T Isikawa, M Mihara, K Nakashiro, H Hamakawa 2004

[雑誌論文] Gefinitib ('Iressa', ZD1839), an eppidermal growth factor receptor tyrosine kinase inhibitor, up-regulates p27KIP1 and induces G1 arrest in oral squamous cell carcinoma cell lines

S Shintani, C Li, M Mihara, J Yano, N Terakado, K Nakashiro, H Hamakawa 2004

[雑誌論文] Constitutive activation of Stat3 correlates with increased expression of the c-Met/HGF receptor in oral squamous cell carcinoma..

Klosek SK, Nakashiro K, Hara S, Li C, Shintani S, Hamakawa H 2004

[雑誌論文] Gefinitib ('Iressa', ZD1839), an eppidermal growth factor receptor tyrosine kinase inhibitor, up-regulates p27KIP1 and induces G1 arrest in oral squamous cell carcinoma cell lines.

S Shintani, C Li, M Mihara, J Yano, N Terakado, K Nakashiro, H Hamakawa 2004

[雑誌論文] Skp2 and Jab1 expression are associated with inverse expression of p27KIP1 and poor prognosis in oral squamous cell carcinomas.

S Shintani, C Li, M Mihara, S Hino, K Nakashiro, H Hamakawa. 2004

[雑誌論文] Intraoperative real-time genetic diagnosis for sentinel node navigation surgery

H Hamakawa, A Onishi, T Sumida, N Terakado, S Hino, K Nakashiro, S Shintani 2004

[雑誌論文] Constitutive activation of Stat3 correlates with increased expression of the c-Met/ IHGF receptor in oral squamous cell carcinoma.

Klosek SK, Nakashiro K, Hara S, Li C, Shintani S, Hamakawa H 2004

[雑誌論文] Skp2 and Jab1 expression are associated with inverse expression of p27KIP1 and poor prognosis in oral squamous cell carcinomas

S Shintani, C Li, M Mihara, S Hino, K Nakashiro, H Hamakawa 2004

[雑誌論文] Growth regulated oncogene 1 expression is associated with angiogenesis and lymph node metastasis in human oral cancer

Shintani S, T.Ishikawa, T.Nonaka, C.Li, K.Nakashiro, D.T.W.Wong, H.Hamakawa 2004

[雑誌論文] Expression of vascular endothelial growth factor A, B, C, and D in oral squamous cell carcinoma.

S Shintani, C Li, M Mihara, T Isikawa, M Mihara, K Nakashiro, H Hamakawa 2004

[雑誌論文] Basic and clinical studies on quantitative analysis of lymph node micrometastasis in oral cancer

A Onishi, K Nakashiro, M Mihara, T Sumida, H Kawamata, S Shintani, T Aida, T Tachikawa, H Hamakawa 2004

[雑誌論文] Constitutive activation of Stat3 correlates with increased expression of the c-Met/HGF receptor in oral squamous cell carcinoma

Klosek SK, Nakashiro K, Hara S, Li C, Shintani S, Hamakawa H: 2004

[雑誌論文] Intraoperative real-time genetic diagnosis for sentinel node navigation surgery.

H Hamakawa, A Onishi, T Sumida, N Terakado, S Hino, K Nakashiro, S Shintani 2004

[雑誌論文] Up-regulation of DNA-dependent protein kinase correlates with radiation resistance in oral squamous cell carcinoma

S Shintani, M Mihara, C Li, Y Nakahara, K Nakashiro, Hamakawa H 2003

[雑誌論文] Flavopiridol, a cyclin dependent kinase (CDK) inhibitor, induces apoptosis by regulating Bcl-x in oral cancer cells.

M.Mihara, S.Shintani, K.Nakashiro, H.Hamakawa 2003

[雑誌論文] Thiazolidinediones inhibit cell growth of human oral squamous cell carcinoma in vitro independent of peroxisome proliferator-activated receptor gamma

Nakashiro K, Begum NM, Uchida D, Kawamata H, Shintani S, Sato M, Hamakawa H 2003

[雑誌論文] Gefitinib ('Iressa'), an epidermal growth factor receptor tyrosine kinase inhibitor, mediates the inhibition of lymph node metastasis in oral cancer cells.

S Shintani, C Li, M Mihara, K Nakashiro, Hamakawa H 2003

[雑誌論文] Possible role of stromal-cell-derived factor-1/CXCR4 signaling on lymph node metastasis of oral squamous cell carcinoma

Uchida D, Begum NM, Almofti A, Nakashiro K, Kawamata H, Tateishi Y, Hamakawa H, Yoshida H, Sato M 2003

[雑誌論文] Enhancement of radiosensitivity in head and neck cancer cells by ZD1839 ('Iressa'), a selective epidermal growth factor receptor tyrosine kinase inhibitor

Shintani S, Kiyota A, Mihara M, Sumida T, Kayahara H, Nakashiro K, Hamakawa H. 2003

[雑誌論文] Flavopiridol, a cyclin dependent kinase (CDK) inhibitor, induces apoptosis by regulating Bcl-x in oral cancer cells

M.Mihara, S.Shintani, K.Nakashiro, H.Hamakawa 2003

[雑誌論文] Enhancement of radiosensitivity in head and neck cancer cells by ZD1839 ('Iressa'), a selective epidermal growth factor receptor tyrosine kinase inhibitor.

Shintani S, Kiyota A, Mihara M, Sumida T, Kayahara H, Nakashiro K, Hamakawa H 2003

[雑誌論文] Thiazolidinediones inhibit cell growth of human oral squamous cell carcinoma in vitro independent of peroxisome proliferator-activated receptor gamma.

Nakashiro K, Begum NM, Uchida D, Kawamata H, Shintani S, Sato M, Hamakawa H 2003

[雑誌論文] Enhancement of tumor radioresponse by combined treatment with gefitinib (Iressa, ZD1839), an epidermal growth factor receptor tyrosine kinase inhibitor, is accompanied by inhibition of DNA damage repair and cell growth in oral cancer.

S Shintani, C Li, M Mihara, N Terakado, K Nakashiro, Hamakawa H 2003

[雑誌論文] Possible role of stromal-cell-derived factor-1/CXCR4 signaling on lymph node metastasis of oral squamous cell carcinoma.

Uchida D, Begum NM, Almofti A, Nakashiro K, Kawamata H, Tateishi Y, Hamakawa H, Yoshida H, Sato M 2003

[雑誌論文] Up-regulation of DNA-dependent protein kinase correlates with radiation resistance in oral squamous cell carcinoma.

S Shintani, M Mihara, C Li, Y Nakahara, K Nakashiro, Hamakawa H 2003

[雑誌論文] Enhancement of tumor radioresponse by combined treatment with gefitinib (Iressa, ZD1839), an epidermal growth factor receptor tyrosine kinase inhibitor, is accompanied by inhibition of DNA damage repair and cell growth in oral cancer

S Shintani, C Li, M Mihara, N Terakado, K Nakashiro, Hamakawa H. 2003

[雑誌論文] Gefitinib ('Iressa'), an epidermal growth factor receptor tyrosine kinase inhibitor, mediates the inhibition of lymph node metastasis in oral cancer cells

S Shintani, C Li, M Mihara, K Nakashiro, Hamakawa H. 2003