トップ›研究者を探す›Toll様受容体-4シグナル:口腔癌における抗癌剤・放射線治療の増強効果

Toll様受容体-4シグナル:口腔癌における抗癌剤・放射線治療の増強効果

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-14207090
研究種目 基盤研究(A)
研究分野 医学
歯学
外科系歯学
研究機関 徳島大学
代表研究者 佐藤 光信
研究分担者 東 雅之
研究分担者 岡本 正人
研究分担者 原田 耕志
研究期間 開始年月日 2002/4/1
研究期間 終了年度 2005
研究ステータス 完了 (2005/4/1)
配分額（合計） 50,440,000 (直接経費 :38,800,000、間接経費 :11,640,000)
配分額（履歴） 2005年度：5,980,000 (直接経費 :4,600,000、間接経費 :1,380,000)
2004年度：7,540,000 (直接経費 :5,800,000、間接経費 :1,740,000)
2003年度：10,530,000 (直接経費 :8,100,000、間接経費 :2,430,000)
2002年度：26,390,000 (直接経費 :20,300,000、間接経費 :6,090,000)
キーワード 口腔癌
Toll-like receptor 4
MD-2
OK-432
UFT
放射線
リポタイコ酸関連分子
NF-κB
Toll-like receptor4
抗腫瘍免疫療法剤OK-432
リポタイコ酸関連分子OK-PSA
Toll様受容体4
テガフール
樹状細胞(DC)
DC局所療法
リポタイコ酸
NF-kB
Oral cancer
Toll-like receptor 4
MD-2
OK-432
UFT
Radiation
Lipoteichoic acid-related molecule
NF-κB

研究成果

[雑誌論文] Mechanism of anti-cancer host response induced by OK-432,a streptococcal preparation, mediated by phagocytosis and Toll-like receptor 4 signaling.

Masato Okamoto 2006

[雑誌論文] Mechanism of anti-cancer host response induced by OK-432, a streptococcal preparation, mediated by phagocytosis and Toll-like receptor 4 signaling

Masato Okamoto 2006

[雑誌論文] Mechanism of anti-cancer host response induced by OK-432, a streptococcal preparation, mediated by phagocytosis and Toll-like receptor 4 signaling.

Masato Okamoto 2006

[図書] Streptococcal preparation, OK-432-based immunotherapy for head and neck cancer : Possible stimulation of dendritic cells via Toll-Like Receptor 4

Masato Okamoto 2005

[雑誌論文] Potentiation of induction of apoptosis by sequential treatment with cisplatin followed by 5-fluorouracil in human oral cancer cells

Masayuki Azuma 2004

[雑誌論文] Expression of toll-like receptor 4 on dendritic cells is significant for anticancer effet of dendritic cell-based immunotherapy in conbination with an active component of OK-432, a streptococcal preparation

Masato Okamoto 2004

[雑誌論文] Expression of Toll-like receptor 4 on dendritic cells is significant for anti cancer effect of dendritic cell-based immunotherapy in combination with an active component of OK-432,a streptococcal preparation.

Masato Okamoto 2004

[雑誌論文] Expression of Toll-like receptor 4 on dendritic cells is significant for anti-cancer effect of dendritic cell-based immunotherapy in combination with an active component of OK-432, a streptococcal preparation.

Masato Okamoto 2004

[雑誌論文] Cisplatin induces apoptosis in oral squamous carcinoma cells by the mitochondria-mediated but not the NF-kB-suppressed pathway.

Masayuki Azuma 2003

[雑誌論文] Cisplatin induces apoptosis in oral squamous carcinoma cells by the mitochondria-mediated but not the NF-kB-suppressed pathway.

Masayuki Azuma 2003

[雑誌論文] Involvement of Toll-like receptor 4 signaling in interferon-g production and anti-tumor effect by a streptococcal agent OK-432.

Masato Okamoto 2003

[図書] Current progress of human cancer gene therapy-Head and neck cancer-(Oral Surgery Hand Manual)(Seto K, Noma H, Katsuki T, Ueda M (ed.))

Mitsunobu Sato 2003

[図書] Effective molecule of a streptococcal preparation OK-432 and its molecular targets : Significance for cancer immunotherapy. (Recent Research Development in Infection & Immunity Vol 1)(S.G.Pandalai (ed.))

Masato Okamoto 2003

[雑誌論文] Involvement of Toll-like receptor 4 signaling in interferon-g production and ante-tumor effect by a streptococcal agent OK-432.

Masato Okamoto 2003

[図書] Effective molecule of a streptococcal preparation OK-432 and its molecular targets : Significance for cancer immunotherapy.

Masato Okamoto 2003

[雑誌論文] Enhancement of anti-tumor immunity by lipoteichoic acid-related molecule isolated from OK-432, a streptococcal agent, in athymic nude mice bearing human salivary adenocarcinoma : Role of natural killer cells.

Masato Okamoto 2002

[雑誌論文] Enhancement of anti-tumor immunity by lipoteichoic acid-related molecule isolated from OK-432,a streptococcal agent, in athymic nude mice bearing human salivary adenocarcinoma : Role of natural killer cells.

Masato Okamoto 2002