研究成果

[雑誌論文] Loss of core fucosylation of low-density lipoprotein receptor-related protein-1 impairs its function, leading to the upregulation of serum levels of insulin-like growth factor-binding protein 3 in fut8-/-mice.

Lee, S.H., Takahashi, M., Honke, K., Miyoshi, E., Osumi, D., Sakiyama, H., Ekuni, A., Wang, X., Inoue, S., Gu, J., Kadomatsu, K.., Taniguchi, N. 2006

[雑誌論文] A specific detection of GlcNAc {beta} 1-6Man {alpha} 1 branches in N-linked glycoproteins based on the specificity of N-acetylglucosaminyltransferase VI.

Watanabe, T., Ihara, H., Miyoshi, E., Honke, K., Taniguchi, N., Taguchi, T. 2006

[雑誌論文] Dysregulation of TGF-beta1 receptor activation leads to abnormal lung development and emphysema-like phenotype in core fucose-deficient mice.

Wang, X., Inoue, S., Gu, J., Miyoshi, E., Noda, K., Li, W., Mizuno-Horikawa, Y., Nakano, M., Asahi, M., Takahashi, M., Uozumi, N., Ihara, S., Lee, S.H., Ikeda, Y., Yamaguchi, Y., Aze, Y., Tomiyama, Y., Fujii, J., Suzuki, K., Kondo, A., Shapiro, S.D., Lopez-Otin, C., Kuwaki, T., Okabe, M., Honke, K., Taniguchi, N. 2006

[雑誌論文] Modification of oligosaccharides by reactive oxygen species decreases sialyl lewis x-mediated cell adhesion.

Eguchi, H., Ikeda, Y., Ookawara, T., Koyota, S., Fujiwara, N., Honke, K., Wang, P.G., Taniguchi, N., Suzuki, K. 2005

[雑誌論文] Testis-specific sulfoglycolipid, seminolipid, is essential for germ cell function in spermatogenesis.

Zhang Y, Hayashi Y, Cheng X, Watanabe T, Wang X, Taniguchi N, Honke K. 2005

[雑誌論文] Production of a recombinant single-chain variable-fragment (scFv) antibody against sulfoglycolipid.

Cheng, X., Zhang, Y., Kotani, N., Watanabe, T., Lee, S., Wang, X., Kawashima, I., Tai, T., Taniguchi, N., Honke, K. 2005

[雑誌論文] Dysregulation of TGF-beta1 receptor activation leads to abnormal lung development and emphysema-like phenotype in core fucose-deficient mice.

Wang, X., Inoue, S., Gu, J., Miyoshi, E., Noda, K., Li, W., Mizuno-Horikawa, Y., Nakano, M., Asahi, M., Takahashi, M., Uozumi, N., Ihara, S., Lee, S.H., Ikeda, Y., Yamaguchi, Y., Aze, Y., Tomiyama, Y., Fujii, J., Suzuki, K., Kondo, A., Shapiro, S.D., Lopez-Otin, C., Kuwaki, T., Okabe, M., Honke, K., Taniguchi, N. 2005

[雑誌論文] Bisecting GlcNAc mediates the binding of annexin V to Hsp47.

Gao, C.X., Miyoshi, E., Uozumi, N., Takamiya, R., Wang, X., Noda, K., Gu, J., Honke, K., Wada, Y., Taniguchi, N. 2005

[雑誌論文] Introduction of bisecting GlcNAc into integrin alpha5betal reduces ligand binding and down-regulates cell adhesion and cell migration.

Isaji, T., Gu, J., Nishiuchi, R, Zhao, Y., Takahashi, M., Miyoshi, E., Honke, K., Sekiguchi, K.., Taniguchi, N. 2004

[雑誌論文] Biological roles of sulfoglycolipids and pathophysiology of their deficiency.

Honke K et al. 2004

[雑誌論文] N-Acetylglucosaminyltransferase IX acts on the GlcNAc beta 1,2-Man alpha 1-Ser/Thr moiety, forming a 2,6-branched structure in brain O-mannosyl glycan.

Inamori, K., Endo, T., Gu, J., Matsuo, I., Ito, Y., Fujii, S., Iwasaki, H., Narimatsu, H., Miyoshi, E., Honke, K.., Taniguchi, N. 2004

[雑誌論文] Betal,4-N-Acetylglucosaminyltransferase III down-regulates neurite outgrowth induced by costimulation of epidermal growth factor and integrins through the Ras/ERK signaling pathway in PC12 cells.

Gu, J., Zhao, Y., Isaji, T., Shibukawa, Y., Ihara, H., Takahashi, M., Ikeda, Y., Miyoshi, E., Honke, K.., Taniguchi, N. 2004

[雑誌論文] Cerebroside sulfotransferase deficiency ameliorates L-selectin-dependent monocyte infiltration in the kidney after ureteral obstruction.

Ogawa, D., Shikata, K., Honke, K., Sato, S., Matsuda, M., Nagase, R., Tone, A., Okada, S., Usui, H., Wada, J., Miyasaka, M., Kawashima, H., Suzuki, Y., Suzuki, T., Taniguchi, N., Hirahara, Y., Tadano-Aritomi, K., Ishizuka, I., Tedder, T.F., Makino, H. 2004

[雑誌論文] Role of N-glycans in growth factor signaling.

Takahashi, M., Tsuda, T., Ikeda, Y., Honke, K.., Taniguchi, N. 2004

[雑誌論文] Addition of betal-6 GlcNAc branching to the oligosaccharide attached to Asn 772 in the serine protease domain of matriptase plays a pivotal role in its stability and resistance against trypsin.

Ihara, S., Miyoshi, E., Nakahara, S., Sakiyama, H., Ihara, H., Akinaga, A., Honke, K., Dickson, R.B., Lin, C.Y., Taniguchi, N. 2004

[雑誌論文] Lactosylsulfatide expression in hepatocellular carcinoma cells enhances cell adhesion to vitronectin and intrahepatic metastasis in nude mice.

Zhong Wu, X., Honke, K., Long Zhang, Y., Liang Zha, X., Taniguchi, N. 2004

[雑誌論文] Biological roles of sulfoglycolipids and pathophysiology of their deficiency.

Honke, K., Zhang, Y., Cheng, X., Kotani, N., Taniguchi, N. 2004

[雑誌論文] Identification of the binding site of methylglyoxal on glutathione peroxidase : methylglyoxal inhibits glutathione peroxidase activity via binding to glutathione binding sites Arg 184 and 185.

Park, Y.S., Koh, Y.H., Takahashi, M., Miyamoto, Y., Suzuki, K., Dohmae, N., Takio, K., Honke, K.., Taniguchi, N. 2003

[雑誌論文] Carbohydrate binding activity of annexin V toward a bisecting N-acetylglucosamine.

Gao, C.X., Honke, K.., Taniguchi, N. 2003

[雑誌論文] Differences in recognition of sulfated and sialylated carbohydrate chains.

Honke, K., Ikeda, N., Taniguchi, N. 2003

[雑誌論文] Molecular cloning and characterization of human GnT-IX, a novel betal,6-N-acetylglucosaminyltransferase that is specifically expressed in the brain.

Inamori, K., Endo, T., Ide, Y., Fujii, S., Gu, J., Honke, K.., Taniguchi, N. 2003

[雑誌論文] Purification and cDNA cloning of UDP-GlcNAc : GlcNAcbetal-3Galbetal-4Glc(NAc)-R [GlcNAc to Gal]betal,6N-acetylglucosaminyltransferase from rat small intestine : a major carrier of dIGnT activity in rat small intestine.

Korekane, H., Taguchi, T., Sakamoto, Y., Honke, K., Dohmae, N., Salminen, H., Toivonen, S., Helin, J., Takio, K., Renkonen, 0., Taniguchi, N. 2003

[雑誌論文] Caveolin-1 regulates the functional localization of N-acetylglucosaminyltransferase III within the golgi apparatus.

Sasai, K., Ikeda, Y., Ihara, H., Honke, K., Taniguchi, N. 2003

[雑誌論文] Differences in recognition of sulfated and sialylated carbohydrate chains.

Honke K et al. 2003

[雑誌論文] Relationship between elevated FX expression and increased production of GDP-L-fucose, a common donor substrate for fucosylation in human hepatocellular carcinoma and hepatoma cell lines.

Noda, K., Miyoshi, E., Gu, J., Gao, C.X., Nakahara, S., Kitada, T., Honke, K., Suzuki, K., Yoshihara, H., Yoshikawa, K., Kawano, K., Tonetti, M., Kasahara, A., Hori, M., Hayashi, N., Taniguchi, N. 2003

[雑誌論文] Down-regulation of hydrogen peroxide-induced PKC delta activation in N-acetylglucosaminyltransferase III-transfected HeLaS3 cells.

Shibukawa, Y., Takahashi, M., Laffont, I., Honke, K.., Taniguchi, N. 2003

[雑誌論文] Involvement of oligosaccharide changes in alpha5betal integrin in a cisplatin-resistant human squamous cell carcinoma cell line.

Nakahara, S., Miyoshi, E., Noda, K., Ihara, S., Gu, J., Honke, K., Inohara, H., Kubo, T., Taniguchi, N. 2003

[雑誌論文] The enzymatic basis for the conversion of nonfucosylated to fucosylated alpha-fetoprotein by acyclic retinoid treatment in human hepatoma cells : activation of alphal-6 fucosyltransferase.

Noda, K., Miyoshi, E., Kitada, T., Nakahara, S., Gao, C.X., Honke, K., Shiratori, Y., Moriwaki, H., Sasaki, Y., Kasahara, A., Hori, M., Hayashi, N., Taniguchi, N. 2002

[雑誌論文] The action of N-acetylglucosaminyltransferase-V is prevented by the bisecting GlcNAc residue at the catalytic step.

Sasai, K., Ikeda, Y., Eguchi, H., Tsuda, T., Honke, K.., Taniguchi, N. 2002

[雑誌論文] An enzymatic method of analysis for GDP-L-fucose in biological samples, involving high-performance liquid chromatography.

Noda, K., Miyoshi, E., Nakahara, S., Ihara, H., Gao, C.X., Honke, K., Yanagidani, S., Sasaki, Y., Kasahara, A., Hori, M., Hayashi, N., Taniguchi, N. 2002

[雑誌論文] Prometastatic effect of N-acetylglucosaminyltransferase V is due to modification and stabilization of active matriptase by adding beta 1-6 GlcNAc branching.

Ihara, S., Miyoshi, E., Ko, J.H., Murata, K., Nakahara, S., Honke, K., Dickson, R.B., Lin, C.Y., Taniguchi, N. 2002

[雑誌論文] A glycomic approach to hepatic tumors in N-acetylglucosaminyltransferase III (GnT-III) transgenic mice induced by diethylnitrosamine (DEN) : identification of haptoglobin as a target molecule of GnT-III.

Ekuni, A., Miyoshi, E., Ko, J.H., Noda, K., Kitada, T., Ihara, S., Endo, T., Hino, A., Honke, K.., Taniguchi, N. 2002

[雑誌論文] A catalytically inactive beta 1,4-N-acetylglucosaminyltransferase III (GnT-III) behaves as a dominant negative GnT-III inhibitor.

Ihara, H., Ikeda, Y., Koyota, S., Endo, T., Honke, K.., Taniguchi, N. 2002

[雑誌論文] The possibility of reducing xenoantigen levels with a novel gal 3'-sulfotransferase (GP3ST).

Koma, M., Miyagawa, S., Honke, K., Nakai, R., Miyoshi, S., Ohta, M., Matsuda, H., Shirakura, R., Taniguchi, N. 2002

[雑誌論文] Paranodal junction formation and spermatogenesis require sulfoglycolipids.

Honke, K., Hirahara, Y., Dupree, J., Suzuki, K., Popko, B., Fukushima, K., Fukushima, J., Nagasawa, T., Yoshida, N., Wada, Y., Taniguchi, N. 2002

[雑誌論文] Sulfotransferases and sulfated oligosaccharides.

Honke K et al. 2002

[雑誌論文] Oxidative damage due to copper ion and hydrogen peroxide induces GlcNAc-specific cleavage of an Asn-linked oligosaccharide.

Eguchi, H., Ikeda, Y., Koyota, S., Honke, K., Suzuki, K., Gutteridge, J.M., Taniguchi, N. 2002

[雑誌論文] A secreted type of beta 1,6-N-acetylglucosaminyltransferase V (GnT-V) induces tumor angiogenesis without mediation of glycosylation : a novel function of GnT-V distinct from the original glycosyltransferase activity.

Saito, T., Miyoshi, E., Sasai, K., Nakano, N., Eguchi, H., Honke, K.., Taniguchi, N. 2002

[雑誌論文] Sulfotransferases and sulfated oligosaccharides.

Honke, K.., Taniguchi, N. 2002

[雑誌論文] Paranodal junction formation and spermatogenesis require sulfoglycolipids.

Honke K et al. 2002

[雑誌論文] A remodeling system of the 3'-sulfo-Lewis a and 3'-sulfo-Lewis x epitopes.

Ikeda, N., Eguchi, H., Nishihara, S., Narimatsu, H., Kannagi, R, Irimura, T., Ohta, M., Matsuda, H., Taniguchi, N., Honke, K. 2001

[雑誌論文] Overexpression of N-acetylglucosaminyltransferase III enhances the epidermal growth factor-induced phosphorylation of ERK in HeLaS3 cells by up-regulation of the internalization rate of the receptors.

Sato, Y., Takahashi, M., Shibukawa, Y., Jain, S.K., Hamaoka, R., Miyagawa, J., Yaginuma, Y., Honke, K., Ishikawa, M., Taniguchi, N. 2001

[雑誌論文] Down-regulation of the alpha-Gal epitope expression in N-glycans of swine endothelial cells by transfection with the N-acetylglucosaminyltransferase III gene. Modulation of the biosynthesis of terminal structures by a bisecting GlcNAc.

Koyota, S., Ikeda, Y., Miyagawa, S., Ihara, H., Koma, M., Honke, K., Shirakura, R., Taniguchi, N. 2001

[雑誌論文] Domain-specific mutations of a transforming growth factor (TGF)-beta 1 latency-associated peptide cause Camurati-Engelmann disease because of the formation of a constitutively active form of TGF-beta 1.

Saito, T., Kinoshita, A., Yoshiura, K., Makita, Y., Wakui, K., Honke, K., Niikawa, N., Taniguchi, N. 2001

[雑誌論文] A glycomic approach to the identification and characterization of glycoprotein function in cells transfected with glycosyltransferase genes.

Taniguchi, N., Ekuni, A., Ko, J.H., Miyoshi, E., Ikeda, Y., Ihara, Y., Nishikawa, A., Honke, K.., Takahashi, M. 2001

[雑誌論文] Ectopic expression of alphal,6 fucosyltransferase in mice causes steatosis in the liver and kidney accompanied by a modification of lysosomal acid lipase.

Wang, W., Li, W., Ikeda, Y., Miyagawa, J.I., Taniguchi, M., Miyoshi, E., Sheng, Y., Ekuni, A., Ko, J.H., Yamamoto, Y., Sugimoto, T., Yamashita, S., Matsuzawa, Y., Grabowski, G.A., Honke, K., Taniguchi, N 2001

[雑誌論文] Molecular cloning and characterization of a human beta-Gal-3'-sulfotransferase that acts on both type 1 and type 2 (Gal beta 1-3/1-4GlcNAc-R) oligosaccharides.

Honke, K., Tsuda, M., Koyota, S., Wada, Y., Iida-Tanaka, N., Ishizuka, I., Nakayama, J., Taniguchi, N. 2001

[雑誌論文] Molecular cloning and characterization of a human beta-Gal-3'-sulfotransferase that acts on both type 1 and type 2 (Gal beta l-3/1-4GlcNAc-R) oligosaccharides.

Honke K et al. 2001