トップ›研究者を探す›プロテオーム解析によるサルモネラ属細菌の感染制御機構に関する研究

プロテオーム解析によるサルモネラ属細菌の感染制御機構に関する研究

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-13470058
研究種目 基盤研究(B)
研究分野 医学
病理
細菌学(含真菌学)
研究機関 千葉大学
代表研究者 山本 友子
研究分担者 友安 俊文
研究分担者 高屋 明子
研究期間 開始年月日 2001/4/1
研究期間 終了年度 2004
研究ステータス 完了 (2004/4/1)
配分額（合計） 14,300,000 (直接経費 :14,300,000)
配分額（履歴） 2004年度：2,100,000 (直接経費 :2,100,000)
2003年度：2,100,000 (直接経費 :2,100,000)
2002年度：4,900,000 (直接経費 :4,900,000)
2001年度：5,200,000 (直接経費 :5,200,000)
キーワード サルモネラ
プロテオーム
マクロファージ
病原性
アポトーシス
分子シャペロン
Lon
ClpXP
SPI1
Lonプロテアーゼ
ClpXPプロテアーゼ
侵入性
鞭毛
ストレス蛋白質
Salmonella
Proteome
Macrophage
Pathogenesis
Apoptosis
Molecular Chaperone
Lon
ClpXP

研究成果

[雑誌論文] Derepression of Salmonella pathogenicity island 1 genes within macrophages leads to rapid apoptosis via caspase-1- and caspase-3-dependent pathways

A.Takaya, A.Suzuki, Y.Kikuchi, M.Eguchi, E.Isogai, T.Tomoyasu, T.Yamamoto 2005

[雑誌論文] Derepression of Salmonella pathogenicity island 1 genes within macrophages leads to rapid apoptosis via caspase-1-and caspase-3-dependent pathways.

A.Takaya, A.Suzuki, Y.Kikuchi, M.Eguchi, E.Isogai, T.Tomoyasu, T.Yamamoto 2005

[雑誌論文] Derepression of Salmonella pathogenicity island 1 genes within macrophages leads to rapid apoptosis via caspase-1- and caspase-3-dependent pathways

A.Takaya, A.Suzuki, Y.Kikuchi, M.Eguchi, E.Isogai, T.Tomoyasu, T.Yamamoto 2005

[雑誌論文] The DnaK-DnaJ chaperone machinery of Salmonella enterica serovar Typhimurium is essential for invasion of epithelial cells and survival in macrophages, leading to systemic infection.

A.Takaya, T.Tomoyasu, H.Matsui, T.Yamamoto 2004

[雑誌論文] The DnaK-DnaJ chaperone machinery of Salmonella enterica serovar Typhimurium is essential for invasion of epithelial cells and survival in macrophages, leading to systemic infection.

A.Takaya, T.Tomoyasu, H.Matsui, T.Yamamoto 2004

[雑誌論文] Lon, a stress induced A ATP-dependent protease is critically important for the systemic Salmonella infection of mice.

A.Takaya, M.Suzuki, H.Matsui, T.Tomoyasu, H.Sashinami, A.Nakane, T.Yamamoto 2003

[雑誌論文] Turnover of FlhD and FlhC, masterregulator proteins for Salmonella flagellum biogenesis, by the ATP dependent ClpXP protease

T.Tomoyasu, A.Takaya, E.Isogai, T.Yamamoto 2003

[雑誌論文] Oral immunization with ATP-dependent protease deficient mutants protects mice against subsequent oral challenge with virulent Salmonella enterica serovar Typhimurium.

H.Matsui, M.Suzuki, Y.Isshiki, C.Kodama, M.Eguchi, Y.Kikuchi, K.Motokawa, A.Takaya, T.Tomoyasu, T.Yamamoto 2003

[雑誌論文] Lon, a stress-induced ATP-dependent protease, is critically important for the systemic Salmonella enterica serovar Typhamurium infection of mice.

A.Takaya, M.Suzuki, H.Matsui, T.Tomoyasu, H.Sashinami, A.Nakane, T.Yamamoto 2003

[雑誌論文] A new heat shock gene agsA, which encodes a small chaperone involved in suppressing protein aggregation in salmonella entrica serovar Typhimurium

T.Tomoyasu, A.Takaya, T.Sasaki, T.Nagase, R.Kikuno, M.Morioka, T.Yamamoto 2003

[雑誌論文] Turnover of FlhD and FlhC, master regulator proteins for Salmonella flagellum biogenesis, by the ATP-dependent ClpXP protease.

T.Tomoyasu, A.Takaya, E.Isogai, T.Yamamoto 2003

[雑誌論文] Oral immunization with ATP-dependent protease-deficient mutants protects mice against subsequent oral challenge with virulent Salmonella enterica serovar Typhimurium.

H.Matsui, M.Suzuki, Y.Isshiki, M.Eguchi, T.Kikuchi, K.Motokawa, A.Takaya, T.Tomoyasu, T.Yamamoto 2003

[雑誌論文] A new heat-shock gene-agsA, which encodes a small chaperone involved in suppressing protein aggregation in Salmonella enterica serovar Typhimurium.

T.Tomoyasu, A.Takaya, T.Sasaki, T.Nagase, R.Kikuno, M.Morioka T.Yamamoto 2003

[雑誌論文] 総説:大腸菌のトリガーファクター

友安俊文 2002

[雑誌論文] The ATP-dependent Lon protease of Salmonella enterica serovar Typhimurium regulates invasion and expression of genes carried on Salmonella pathogenicity island 1

A.Takaya, T.Tomoyasu, A.Tokumitsu, M.Morioka, T.Yamamoto 2002

[雑誌論文] The ClpXP ATP-dependent protease regulates flagellum Synthesis in Salmonella enterica serovar Typhimurium.

T.Tomoyasu, T.Ohkishi, Y.Ukyo, A.Tokumitsu, A.Takaya, M.Suzuki, K.Sekiya, H.Matsui, K.Kutsukake, T.Yamamoto 2002

[雑誌論文] The ATP-dependent Lon protease of Salmonella enterica serovar Typhimurium regulates invasion and expression of genes carried on Salmonella pathogenicity island 1.

A.Takaya, T.Tomoyasu, A.Tokumitsu, M.Morioka, T.Yamamoto 2002

[雑誌論文] The ClpXP ATP-dependent protease regulates flagellum Synthesis in Salmonella enterica serovar Typhimurium

T.Tomoyasu, T.Ohkishi, Y.Ukyo, A.Tokumitsu, A.Takaya, M.Suzuki, K.Sekiya, H.Matsui, K.Kutsukake, T.Yamamoto. 2002

[雑誌論文] Disruption of the genes for ClpXP protease in Salmonella enterica serovar Typhimurium results in persistent infection in mice, and development of persistence requires endogenous gamma interferon and tumour necrosis factor alpha.

T.Yamamoto, H.Sashinami, A.Takaya, T.Tomoyasu, H.Matsui, T.Hanawa, S.Kamiya, A.Nakane 2001

[雑誌論文] Disruption of the genes for ClpXP protease in Salmonella enterica serovar Typhimurium results in persistent infection in mice, and development of persistence requires endogenous gamma interferon and tumour necrosis factor alpha

T.Yamamoto, H.Sashinami, A.Takaya, T.Tomoyasu, H.Matsui, T.Hanawa, S.Kamiya, A.Nakane 2001