糖尿病関連遺伝子群の解明 - MATCI 産学連携支援マッチング情報システム

トップ›研究者を探す›糖尿病関連遺伝子群の解明

糖尿病関連遺伝子群の解明

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代表研究者	牧野英一
研究課題番号	KAKENHI-PROJECT-12204007
研究種目	特定領域研究
研究分野
研究機関	愛媛大学
研究分担者	大澤春彦
研究分担者	大沼裕
研究分担者	橋本尚武
研究期間開始年月日	2000/4/1
研究期間終了年度	2004
研究ステータス	完了 (2004/4/1)
配分額（合計）	47,100,000 (直接経費 :47,100,000)
配分額（履歴）	2004年度：9,600,000 (直接経費 :9,600,000) 2003年度：11,500,000 (直接経費 :11,500,000) 2002年度：12,000,000 (直接経費 :12,000,000) 2001年度：14,000,000 (直接経費 :14,000,000)
キーワード	糖尿病感受性遺伝子 SNP 多型インスリン抵抗性アディポサイトカインレジスチン転写転写因子ハプロタイプ PDE3B 脂肪細胞インスリン遺伝子疾患感受性 PDE diabetes susceptibility genes SNP polymorphism insulin resistance adipocytokine resistin transcription

研究成果

[雑誌論文] Resistin SNP-420 determines its monocyte mRNA and serum levels inducing type 2 diabetes.

Osawa, H., et al. 2005

[雑誌論文] Resistin SNP-420 determines its monocyte mRNA and serum levels inducing type 2 diabetes.

Osawa H., et al. 2005

[雑誌論文] A newly identified 50 kDa protein which is associated with phosphodiesterase 3B is phosphorylated by insulin in rat adipocytes.

Onuma, H., et al. 2005

[雑誌論文] The G/G Genotype of a resistin single-nucleotide polymorphism at-420 increases type 2 diabetes mellitus susceptibility by inducing promoter activity through specific binding of Sp1/3

Osawa H et al. 2004

[雑誌論文] The G/G Genotype of a resistin single-nucleotide polymorphism at -420increases type 2 diabetes mellitus susceptibility by inducing promoter activity through specific binding of Sp1/3.

Osawa, H., et al. 2004

[雑誌論文] The G/G Genotype of a resistin single-nucleotide polymorphism at -420 increases type 2 diabetes mellitus susceptibility by inducing promoter activity through specific binding of Sp1/3.

Osawa, H., et al. 2004

[雑誌論文] Systematic search for single nucleon a polymorphisms in the FOXC2 gene : The absence of evidence for the association of three frequent single nucleotide polymorphisms and four common haplotypes with Japanese type 2 diabetes.

Osawa, H., et al. 2003

[雑誌論文] Systematic search for single nucleotide polymorphisms in the FOXC2 gene : The absence of evidence for the association of three frequent single nucleotide polymorphisms and four common haplotypes with Japanese type 2 diabetes.

Osawa, H., et al. 2003

[雑誌論文] Systematic search for single nucleotide polymorphisms in the 5' flanking region of the human phosphodiesterase 3B gene : Absence of evidence for major effects of identified polymorphisms on susceptibility to Japanese type 2 diabetes.

Osawa, H., et al. 2003

[雑誌論文] Systematic search for single nucleotide polymorphisms in the 5 flanking region of the human phosphodiesterase 3B gene : Absence of evidence for major effects of identified polymorphisms on susceptibility to Japanese type 2 diabetes.

Osawa, H., et al. 2003

[雑誌論文] Systematic search for single nucleotide polymorphisms in the resistin gene : The absence of evidence for the association of three identified single nucleotide polymorphisms with Japanese type 2 diabetes.

Osawa, H., et al. 2002

[雑誌論文] Identification of the insulin-regulated interaction of phosphodiesterase 3B with 14-3-3 β protein.

Onuma, H., et al. 2002

[雑誌論文] Identification of novel C253Y missense and Y864X nonsense mutations in the insulin receptor gene in type A insulin resistant patients.

Osawa, H., et al. 2001

[雑誌論文] Systematic search for single nucleotide polymorphisms in the insulin gene : Evidence for a high frequency of g.-23T>A in Japanese subjects.

Osawa, H. 2001

[雑誌論文] Systematic search for single nucleotide polymorphisms in the insulin gene : Evidence for a high frequency of g.-23T>A in Japanese subjects.

Osawa, H., et al. 2001

[雑誌論文] A systematic search for single nucleotide polymorphisms (SNPs) in the insulin receptor gene : Association of an sSNP with hyperlipidemia in Japanese type 2 diabetic subjects.

Osawa, H., et al. 2001