トップ›研究者を探す›メタボリックシンドロームにおける内因性リガンドと病原体センサーの機能的意義の解明

メタボリックシンドロームにおける内因性リガンドと病原体センサーの機能的意義の解明

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PLANNED-21117007
研究種目 新学術領域研究(研究領域提案型)
研究分野
研究機関 東京医科歯科大学
代表研究者 小川 佳宏
研究分担者 佐田 政隆
研究期間 開始年月日 2009/4/1
研究期間 終了年度 2013
研究ステータス 完了 (2013/4/1)
配分額（合計） 214,240,000 (直接経費 :164,800,000、間接経費 :49,440,000)
配分額（履歴） 2013年度：38,870,000 (直接経費 :29,900,000、間接経費 :8,970,000)
2012年度：38,870,000 (直接経費 :29,900,000、間接経費 :8,970,000)
2011年度：41,730,000 (直接経費 :32,100,000、間接経費 :9,630,000)
2010年度：40,690,000 (直接経費 :31,300,000、間接経費 :9,390,000)
2009年度：54,080,000 (直接経費 :41,600,000、間接経費 :12,480,000)
キーワード メタボリックシンドローム
病原体センサー
内因性リガンド
マクロファージ
脂肪酸
crown-like structure
NASH
肥満
TLR9
遊離核酸
脂肪組織
Mincle
動脈硬化
血管新生
飽和脂肪酸
TLR4
HMGB-1
ATF3
冠動脈疾患

研究成果

[雑誌論文] Endothelial PGC-1α mediates vascular dysfunction in diabetes

N. Sawada, A. Jiang, F. Takizawa, A. Safdar, A. Manika, Y. Tesmenitsky, K.-T. Kang, J. Bischoff, H. Kalwa, J.L. Sartoretto, Y. Kamei, L.E. Benjamin, H. Watada, Y. Ogawa, Y. Higashikuni, C.W. Kessinger, F.A. Jaffer, T. Michel, M. Sata, K. Croce, R. Tanaka, Z Arany 2014

[学会発表] Epicardial adipose tissue plays a role in the pathogenesis of atherosclerosis

M. Sata 2014

[雑誌論文] HMGB1 plays a critical role in vascular inflammation and lesion formation via toll-like receptor 9

Y. Hirata, H. Kurobe, M. Higashida, D. Fukuda, M. Shimabukuro, Y. Higashikuni, T. Kitagawa, M. Sata 2013

[雑誌論文] Exendin-4, a glucagon-like peptide-1 receptor agonist, attenuates neointimal hyperplasia after vascular injury

Y. Hirata, H. Kurobe, C. Nishio, K. Tanaka, D. Fukuda, E. Uematsu, S. Nishimoto, T. Soeki, N. Harada, H. Sakaue, T. Kitagawa, M. Shimabukuro, N. Nakaya, M. Sata 2013

[雑誌論文] Epicardial adipose tissue volume and adipocytokine imbalance are strongly linked to human coronary atherosclerosis

M. Shimabukuro, Y. Hirata, M. Tabata, M. Dagvasumberel, H. Sato, H. Kurobe, D. Fukuda, T. Soeki, T. Kitagawa, S. Takanashi, M. Sata 2013

[雑誌論文] Androgen receptor promotes sex-independent angiogenesis in response to ischemia and is required for activation of vascular endothelial growth factor receptor signaling

Yoshida S, Aihara KI, Ikeda Y, Sumitomo-Ueda Y, Uemoto R, Ishikawa K, Ise T, Yagi S, Iwase T, Mouri Y, Sakari M, Matsumoto T, Takeyama KI, Akaike M, Matsumoto M, Sata M, Walsh K, Kato S, Matsumoto T 2013

[学会発表] NLRP3 Inflammasome Activation Through the Heart-Brain Interaction Contributes to Adaptive Cardiac Hypertrophy in Response to Pressure Overload

Higashikuni Y, Nagai R, Sata M, Komuro I 2013

[学会発表] Macrophage Toll-like Receptor 9 Signaling Contributes to the Development of Insulin Resistance through the Promotion of Inflammation in Adipose Tissue

Nishimoto S, Fukuda D, Shimabukuro M, Yagi S, Soeki T, Sakaue H, Nakaya Y, Sata M 2013

[雑誌論文] Beneficial effect of a synthetic prostacyclin agonist, ONO-1301, in rat autoimmune myocarditis model

Y. Hirata, H. Kurobe, E. Uematsu, S. Yagi, T. Soeki, H. Yamada, D. Fukuda, M. Shimabukuro, M. Nakayama, K. Matsumoto, Y. Sakai, T. Kitagawa, M. Sata 2013

[学会発表] Epicardial adipose tissue plays a role in the pathogenesis of Atherosclerosis

M. Sata 2012

[学会発表] Inflammation in atherosclerosis and adipose tissue

M. Sata 2012

[雑誌論文] Gender disparities in the association between epicardial adipose tissue volume and coronary atherosclerosis: A 3-dimensional cardiac computed tomography imaging study in Japanese subjects

Dagvasumberel M, Shimabukuro M, Nishiuchi T, Ueno J, Takao S, Fukuda D, Hirata Y, Kurobe H, Soeki T, Iwase T, Kusunose K, Niki T, Yamaguchi K, Taketani Y, Yagi S, Tomita N, Yamada H, Wakatsuki T, Harada M, Kitagawa T, Sata M 2012

[学会発表] Locally applied suramin inhibits angiogenesis in adventitia and arterial lesion progression in apolipoprotein E-deficient mice

Tanaka K, Hirata Y, Tabata Y, Ouchi Y, Sata M 2012

[雑誌論文] The ATP-binding cassette transporter ABCG2 protects against pressure overload-induced cardiac hypertrophy and heart failure by promoting angiogenesis and antioxidant response

Y. Higashikuni, J. Sainz, K. Nakamura, M. Takaoka, S. Enomoto, H. Iwata, T. Kimie, M. Sahara, Y. Hirata, R. Nagai, M. Sata 2012

[雑誌論文] The ATP-binding cassette transporter ABCG2 protects against pressure overload-induced cardiac hypertrophy and heart failure by promoting angiogenesis and antioxidant response

Higashikuni Y, Sainz J, Nakamura K, Takaoka M, Enomoto S, Iwata H, Kimie T, Sahara M, Hirata Y, Nagai R, Sata M 2012

[雑誌論文] The Radioprotective 105/MD-1 complex contributes to diet-induced obesity and adipose tissue inflammation

Y. Watanabe, T. Nakamura, S. Ishikawa, S. Fujisaka, I. Usui, K. Tsuneyama, Y. Ichihara, T. Wada, Y. Hirata, T. Suganami, H. Izaki, S. Akira, K. Miyake, H. Kanayama, M. Shimabukuro, M. Sata, T. Sasaoka, Y. Ogawa, K. Tobe, K. Takatsu, Y. Nagai 2012

[雑誌論文] Augmented angiogenesis in adventitia promotes growth of atherosclerotic plaque in apolipoprotein E-deficient mice

K. Tanaka, D. Nagata, Y. Hirata, Y. Tabata, R. Nagai, M. Sata 2011

[雑誌論文] Coronary atherosclerosis is associated with macrophage polarization in epicardial adipose tissue

Y. Hirata, M. Tabata, H. Kurobe, T. Motoki, M. Akaike, C. Nishio, M. Higashida, H. Mikasa, Y. Nakaya, S. Takanashi, T. Igarashi, T. Kitagawa, M. Sata 2011

[雑誌論文] Increased expression of macrophage-inducible C-type lectin in adipose tissue of obese mice and humans

M. Ichioka, T. Suganami, N. Tsuda, I. Shirakawa, Y. Hirata, N. Satoh-Asahara, Y. Shimoda, M. Tanaka, M. Kim-Saijo, Y. Miyamoto, Y. Kamei, M. Sata, Y. Ogawa 2011

[雑誌論文] Synergistic protection against vascular inflammation with a calcium channel blocker and a statin

Hirata, Y, et al 2011

[雑誌論文] Chronic inflammation and atherosclerosis : A critical role for renin angiotensin system that is activated by lifestyle-related diseases

Sata, M, et al 2011

[雑誌論文] Enhanced Inflammation in Epicardial Fat in Patients With Coronary Artery Disease

Hirata, Y, et al 2011

[雑誌論文] Bone marrow-derived cells contribute to vascular inflammation but do not differentiate into smooth muscle cell lineages

H. Iwata, I. Manabe, K. Fujiu, T. Yamamoto, N. Takeda, K. Eguchi, A. Furuya, M. Kuro-o, M. Sata, R. Nagai 2010

[学会発表] Vascular injury and repair : beyond the endothelium

M. Sata 2010

[学会発表] Vascular injury anr repair : beyond the endothelium

M.Sata 2010

[学会発表] Orally administered eicosapentaenoic acid reduces and stabilizes atherosclerotic lesions

M.Sata 2010

[雑誌論文] Crucial role of renin-angiotensin system in the pathogenesis of atheroscle rosis

M.Sata, et al 2010

[雑誌論文] Endovascular injury induces rapid phenotypic changes in perivascular adipose tissue

M. Takaoka, H. Suzuki, S. Shioda, K. Sekikawa, Y. Saito, R. Nagai, M. Sata 2010

[学会発表] Atherosclerosis, Angiogenesis and Sex hormones

佐田政隆 2010

[雑誌論文] Periadventitial adipose tissue plays a critical role in vascular remodeling

M. Takaoka, D. Nagata, S. Kihara, S. Shimomura, Y. Kimura, Y. Tabata, Y. Saito, R. Nagai, M. Sata 2009