胸腺における自己形成と認識

トップ›研究者を探す›胸腺における自己形成と認識

代表研究者	高浜洋介
研究課題番号	KAKENHI-PLANNED-19059010
研究種目	特定領域研究
研究分野
研究機関	徳島大学
研究分担者	松本満
研究期間開始年月日	2007/4/1
研究期間終了年度	2011
研究ステータス	完了 (2011/4/1)
配分額（合計）	184,500,000 (直接経費 :184,500,000)
配分額（履歴）	2011年度：45,000,000 (直接経費 :45,000,000、間接経費 :0) 2010年度：45,000,000 (直接経費 :45,000,000、間接経費 :0) 2009年度：31,500,000 (直接経費 :31,500,000) 2008年度：31,500,000 (直接経費 :31,500,000) 2007年度：31,500,000 (直接経費 :31,500,000)
キーワード	免疫学自己識別自己寛容胸腺胸腺微少環境胸腺上皮細胞胸腺プロテアソーム β5t Aire RANKL CCL21 XCL1 胸腺微小環境生命システム形成 AIRE Tリンパ球プロテアソーム

研究成果

[雑誌論文] CCR7 with S1P1 signaling through AP1 for migration of Foxp3+ regulatory T cells controls autoimmune exocrinopathy

Ishimaru N 2012

[雑誌論文] Parkin interacts with Klokinl for mitochondrial import and maintenance of membrane potential

Kuroda Y 2012

[雑誌論文] Rank signaling links the development of invariant γδ T cell progenitors and Aire+ medullary epithelium

Roberts NM, White AJ, Jenkinson WE, Turchinovich G, Nakamura K, Withers DR, McConnell FM, Desanti GE, Benezech C, Parnell SM, Cunningham AF, Paolino M, Penninger J, Simon K, Nitta T, Ohigashi I, Takahama Y, Caamano JH, Hayday AC, Lane PJ, Jenkinson EJ, Anderson G 2012

[学会発表] Thymic microenvironment and repertoire selection of T cells

Yousuke Takahama 2012

[学会発表] T lymphocyte repertoire formation in thymic microenvironments

Yousuke Takahama 2012

[学会発表] T lymphocyte repertoire formation in thymic microenvironments.

Takahama Y. 2012

[雑誌論文] Beta5t-containing thymoproteasome : specific expression in thymic cortical epithelial cells and role in positive selection of CD8+ T cells

Takahama Y 2012

[雑誌論文] Effects of RANKL on the thymic medulla

Ohigashi I 2011

[学会発表] Thymic microenvironments that shape T lymphocyte repertoire

Yousuke Takahama 2011

[学会発表] Mechanisms to establish self-tolerance in the thymic medulla

Yousuke Takahama 2011

[雑誌論文] Medullary interplay for central tolerance

Takahama Y 2011

[学会発表] 胸腺の機能

高浜洋介 2011

[学会発表] Chemokine regulation of central tolerance

Yousuke Takahama 2011

[学会発表] 中枢性免疫寛容と自己免疫疾患

高浜洋介 2011

[学会発表] Molecular Biology of Thymic Microenvironments

Yousuke Takahama 2011

[学会発表] Cytokine circuit that regulates T cell repertoire formation

Yousuke Takahama 2011

[雑誌論文] Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development

Lei Y, Mat Ripen A, Ishimaru N, Ohigashi T, Nagasawa T, Jeker L, Bosl M, Hollander GA, Hayashi Y, de Waal Malefyt R, Nitta T, Takahama Y 2011

[学会発表] Expression of Aire, a gene responsible for autoimmune disease, in ES cells

Matsumoto M 2011

[学会発表] Aire-dependent organization of thymic microenvironment for the establishment of self tolerance

Matsumoto M 2011

[学会発表] Aire-dependent organization of thymic microenvironment for the establishment of self tolerance

Matsumoto M 2011

[学会発表] Role of self-antigen expressed by Aire-expressing cells in the negative selection process

Matsumoto M 2011

[雑誌論文] Contrasting models for the roles of Aire in the differentiation program of epithelial cells in the thymic medulla

Matsumoto, M. 2011

[雑誌論文] Lymphotoxin signal promotes thymic organogenesis by eliciting RANK expression in the embryonic thymic stroma

Mouri Y 2011

[学会発表] 胸腺の構築

高浜洋介 2010

[学会発表] Thymic microenvironments that shape T cell repertoire

Takahama Y. 2010

[雑誌論文] Top three reasons to come to Kobe for the 14th International Congress of Immunology

Takahama Y, Miyasaka M. 2010

[雑誌論文] Thymoproteasome shapes immunocompetent repertoire of CD8+ T cells.

Nitta T, Murata S, Sasaki K, Fujii H, Mat Ripen A, Ishimaru N, Koyasu S, Tanaka K, Takahama Y 2010

[学会発表] XCL1 regulates medullary accumulation of thymic dendritic cells and thymic development of regulatory T cells

Yousuke Takahama 2010

[学会発表] 自己免疫疾患と胸腺

高浜洋介 2010

[学会発表] Thymic microenvironments that shape T cell repertoire

Yousuke Takahama 2010

[雑誌論文] Top three reasons to come to Kobe for the 14th International Congress of Immunology

Takahama Y, et al. 2010

[学会発表] XCL1 regulates medullary accumulation of thymic dendritic cells and thymic development of regulatory T cells

Takahama Y. 2010

[雑誌論文] Role of thymic cortex-specific self-peptides in positive selection of T cells

Takahama Y, et al. 2010

[学会発表] Thymus-specific self-peptide repertoire shaped immunocompetent repertoire of T cells

Yousuke Takahama 2010

[学会発表] T-cell repertoire formation in the thymus

Yousuke Takahama 2010

[学会発表] T-cell repertoire formation in the thymus

Takahama Y. 2010

[学会発表] Aire regulates XCL1-mediated medullary accumulation of thymic dendritic cells and thymic development of regulatory T cells

Yousuke Takahama 2010

[雑誌論文] Thymoproteasome shapes immunocompetent repertoire of CD8+ T cells.

Nitta T, Murata S, Sasaki K, Fujii H, Mat Ripen A, Ishimaru N, Koyasu S, Tanaka K, Takahama Y. 2010

[学会発表] 胸腺におけるT細胞選択と自己免疫疾患

高浜洋介 2010

[雑誌論文] Another zinc finger in the pie of CD4-CD8 lineage choice

Takada K, Takahama Y. 2010

[学会発表] AIRE and autoimmune disease

Mitsuru Matsumoto 2010

[学会発表] Roles of thymic epithelial cells for the establishment of self-tolerance

Mitsuru Matsumoto 2010

[雑誌論文] Biphasic Aire ｅxpression in early embryos and in medullary thymic epithelial cells prior to end-stage terminal differentiation.

Nishikawa Y, Hirota F, Yano M, Kitajima H, Miyazaki J, Kawamoto H, Mouri Y, Matsumoto M 2010

[学会発表] Biphasic Aire expression in early embryos and in medullary thymic epithelial cells prior to end-stage terminal differentiation

Mitsuru Matsumoto 2010

[雑誌論文] CCR7-mediated medulla migration of developing thymocytes is essential for negative selection to tissue-restricted antigens.

Nitta T, Nitta S, Lei Y, Lipp M, Takahama Y 2009

[図書] Systems Biology: The Challenge of Complexity(Toward understanding how the immune system establishes a diverse yet self-tolerant T-cell repertoire: stepwise roles of thymic microenvironments.)

Nitta T, Takahama Y., Nakanishi S, Kageyama R, Watanabe D. 2009

[図書] Systems Biology: The Challenge of Complexity. eds. Nakanishi S, Kageyama R, Watanabe D., Toward understanding how the immune system establishes a diverse yet self-tolerant T-cell repertoire: stepwise roles of thymic microenvironments.

Nitta T, Takahama Y. 2009

[学会発表] Thymus-specific self-peptide repertoire shapes immunocompetent repertoire of T cells

Yousuke Takahama 2009

[学会発表] Thymus-specific self-peptide repertoirｅ shapes immunocompetent repertoire of T cells

Takahama Y. 2009

[図書] 免疫学最新イラストレイテッド改訂第2版

高浜洋介 2009

[学会発表] Positive selection by thymoproteasome-expressing thymic epithelial cells shapes immunocompetent repertoire of CD8 T cells.

Takahama Y. 2009

[雑誌論文] The global thymus network : past, present, and future

Takahama Y, et al. 2009

[雑誌論文] CCR7-mediated medulla migration of developing thymocytes is essential for negative selection to tissue-restricted antigens.

Nitta T, Nitta S, Lei Y, Lipp M, Takahama Y 2009

[学会発表] 胸腺と自己免疫疾患

高浜洋介 2009

[学会発表] Positive selection by thymoproteasome-expressing thymic epithelial cells shapes immunocompetent repertoire of CD8 T cells

Yousuke Takahama 2009

[学会発表] Positive selection by thymoproteasome-expressing thymic epithelial cells shapes immunocompetent repertoire of CD8 T cells

Yousuke Takahama 2009

[学会発表] Aire-dependent organization of thymic microenvironment

Matsumoto M. 2009

[学会発表] Aire-dependent organization of thymic microenvironment

Mitsuru Matsumoto 2009

[雑誌論文] The role of autoimmune regulator (Aire) in the development of the immune system

Matsumoto M. 2009

[学会発表] RANK ligand produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator

Yousuke Takahama 2008

[雑誌論文] The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator.

Hikosaka Y, Nitta T, Ohigashi I, Yano K, Ishimaru N, Hayashi Y, Matsumoto M, Matsuo K, Penninger JM, Takayanagi H, Yokota Y, Yamada H, Yoshikai Y, Inoue J, Akiyama T, Takahama Y. 2008

[雑誌論文] One small step for immunologists

Takahama Y, et.al. 2008

[雑誌論文] The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance.

Akiyama T, Shimo Y, Yanai H, Qin J, Ohshima, D, Maruyama Y, Asaumi Y, Kitazawa J, Takayanagi H, Penninger JM, Matsumoto M, Nitta T, Takahama Y, Inoue J. 2008

[学会発表] Tリンパ球レパトア形成の分子基盤

高浜洋介 2008

[雑誌論文] Modest cortex and promiscuous medulla for thymic repertoire formation

Takahama Y, et.al. 2008

[学会発表] Development of thymus and T lymphocytes in medaka

高浜洋介 2008

[学会発表] The chemokine system in the construction and function of the thymus.

Takahama Y. 2008

[雑誌論文] Autoantigen-specific interactions with CD4+ thymocytes control mature medullary thymic epithelial cell cellularity.

Irla M, Hugues S, Gill J, Nitta T, Hikosaka Y, Williams IR, Hubert FX, Scott HS, Takahama Y, Hollander GA, Reith W 2008

[学会発表] RANK ligand produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator.

Takahama Y. 2008

[学会発表] The chemokine system in the construction and function of the thymus

Yousuke Takahama 2008

[雑誌論文] The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator.

Hikosaka Y, Nitta T, Ohigashi I, Yano K, Ishimaru N, Hayashi Y, Matsumoto M, Matsuo K, Penninger JM, Takayanagi H, Yokota Y, Yamada H, Yoshikai Y, Inoue J, Akiyama T, Takahama Y 2008

[図書] Effector CD4+ T Cells in Health and Disease., Development of helper and regulatory CD4+ T cells in the thymus.

Liu C, Takahama Y. 2008

[学会発表] The chemokine system in the construction and function of the thymus

Takahama Y. 2008

[学会発表] Thymoproteasome governs positive selection of CD8 T cells

Yousuke Takahama 2008

[学会発表] 中枢性自己寛容と自己免疫疾患

高浜洋介 2008

[雑誌論文] Aire controls the differentiation program of thymic epithelial cells in the medulla for the establishment of self-tolerance.

Yano M, Kuroda N, Han H, Meguro-Horike M, Nishikawa Y, Kiyonari H, Maemura K, Yanagawa Y, Obata K, Takahashi S, Ikawa T, Satoh R, Kawamoto H, Mouri Y, Matsumoto M. 2008

[雑誌論文] Targeted deletion of the murine corneodesmosin gene delineates its essential role in skin and hair physiology

Matsumoto M, et.al. 2008

[雑誌論文] Targeted deletion of the murine corneodesmosin gene delineates its essential role in skin and hair physiology.

Matsumoto M, Zhou Y, Matsuo S, Nakanishi H, Hirose K, Oura H, Arase S, Ishida-Yamamoto A, Bando Y, Izumi K, Kiyonari H, Oshima N, Nakayama R, Matsushima A, Hirota F, Mouri Y, Kuroda N, Sano S, Chaplin DD. 2008

[学会発表] Aire controls the differentiation program of medullary thymic epithelial cells

Mitsuru Matsumoto 2008

[学会発表] Aire-dependent organization of thymic microenvironment

松本満 2008

[学会発表] Thymic microenvironments for shaping T-cell repertoire

Takahama Y. 2007

[学会発表] Thymic microenvironments for shaping T-cell repertoire

Yousuke Takahama 2007

[学会発表] Thymic microenvironments and central tolerance

Takahama Y. 2007

[雑誌論文] Regulation of CD8+ T cell development by thymus-specific proteasomes

Murata S, Sasaki K, Kishimoto T, Niwa S, Hayashi H, Takahama Y, Tanaka K. 2007

[学会発表] Cortex-medulla microenvironments for thymocyte development

Yousuke Takahama 2007

[学会発表] Thymic microenvironments and central tolerance

Yousuke Takahama 2007

[雑誌論文] Japanese Society for Immunology goes public: immunology outreach in Japan

Yousuke Takahama 2007

[学会発表] Lessons learned from ENU-mutagenized athymic medaka mutants

Yousuke Takahama 2007

[雑誌論文] Autoimmime regulator functions in autoimmunity control

Mitsuru Matsumoto 2007

[学会発表] Aire-dependent organization of thymic microenvironment for the establishment of self-tolerance

Mitsuru Matsumoto 2007

[学会発表] Transcriptional regulation in the thymus for the establishment of self-tolerance

Mitsuru Matsumoto 2007