トップ›研究者を探す›多細胞システムのパターン形成を駆動するシンギュラリティ細胞の同定と操作

多細胞システムのパターン形成を駆動するシンギュラリティ細胞の同定と操作

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PLANNED-18H05415
研究種目 新学術領域研究(研究領域提案型)
研究分野
研究機関 徳島大学
代表研究者 堀川 一樹
研究分担者 竹本 龍也
研究期間 開始年月日 2018/4/1
研究期間 終了年度 2022
研究ステータス 完了 (2022/4/1)
配分額（合計） 128,960,000 (直接経費 :99,200,000、間接経費 :29,760,000)
配分額（履歴） 2022年度：25,870,000 (直接経費 :19,900,000、間接経費 :5,970,000)
2021年度：26,910,000 (直接経費 :20,700,000、間接経費 :6,210,000)
2020年度：25,480,000 (直接経費 :19,600,000、間接経費 :5,880,000)
2019年度：24,050,000 (直接経費 :18,500,000、間接経費 :5,550,000)
2018年度：26,650,000 (直接経費 :20,500,000、間接経費 :6,150,000)
キーワード 自己組織化
生物物理
cAMP
パターン形成
ゲノム編集
細胞周期
社会性アメーバ
光メモリー

研究成果

[雑誌論文] Intercellular exchange of Wnt ligands reduces cell population heterogeneity during embryogenesis

Yudai Hatakeyama, Nen Saito, Yusuke Mii, Ritsuko Takada, Takuma Shinozuka, Tatsuya Takemoto, Honda Naoki, Shinji Takada 2023

[雑誌論文] Development of a screening system for agents that modulate taste receptor expression with the CRISPR-Cas9 system in medaka

Beppu Kana、Tsutsumi Rie、Ansai Satoshi、Ochiai Nana、Terakawa Mai、Mori Marie、Kuroda Masashi、Horikawa Kazuki、Tomoi Takumi、Sakamoto Joe、Kamei Yasuhiro、Naruse Kiyoshi、Sakaue Hiroshi 2022

[雑誌論文] Live Imaging of cAMP Signaling in D. discoideum Based on a Bioluminescent Indicator, Nano-lantern (cAMP)

Horikawa Kazuki、Nagai Takeharu 2022

[学会発表] 円順列変異体化による 1 蛍光型プローブの機能改良

堀川一樹 2022

[学会発表] 10万細胞の集団に生じる細胞間信号波の形成機構

堀川一樹 2022

[学会発表] 多細胞システムのパターン形成を駆使するシンギュラリティ細胞の同定と操作

堀川一樹 2022

[雑誌論文] Programmed death (PD)‐1/PD‐ligand 1 blockade mediates antiangiogenic effects by tumor‐derived CXCL10/11 as a potential predictive biomarker

Mitsuhashi Atsushi、Kondoh Kensuke、Horikawa Kazuki、Koyama Kazuya、Nguyen Na Thi、Afroj Tania、Yoneda Hiroto、Otsuka Kenji、Ogino Hirokazu、Nokihara Hiroshi、Shinohara Tsutomu、Nishioka Yasuhiko 2021

[学会発表] Onset of the signaling wave at 10,000 cell population

Kazuki Horikawa 2021

[学会発表] 興奮性多細胞システムのトランススケールイメージングで明らかになったらせん状信号波の形成機構

堀川一樹 2021

[雑誌論文] Design and synthesis of gene-directed caged cyclic nucleotides exhibiting cell type selectivity

Suzuki Akinobu Z.、Sakano Taichi、Sasaki Hirona、Watahiki Rei、Sone Masaki、Horikawa Kazuki、Furuta Toshiaki 2021

[雑誌論文] Sox2 gene regulation via the D1 enhancer in embryonic neural tube and neural crest by the combined action of SOX2 and ZIC2

Iida H, Furukawa Y, Teramoto M, Suzuki H, Takemoto T, Uchikawa M, Kondoh H. 2020

[図書] "Zygote Electroporation for CRISPR/Cas9 Delivery to Generate Genetically Modified Mice" in Electroporation Protocols (Methods in Molecular Biology)

Tatsuya Takemoto 2020

[雑誌論文] The absence of SOX2 in the anterior foregut alters the esophagus into trachea and bronchi in both epithelial and mesenchymal components

Teramoto M, Sugawara R, Minegishi K, Uchikawa M, Takemoto T, Kuroiwa A, Ishii Y, Kondoh H. 2020

[雑誌論文] Generation of PDX-1 mutant porcine blastocysts by introducing CRISPR/Cas9-system into porcine zygotes via electroporation

Tanihara F, Hirata M, Nguyen NT, Le QA, Hirano T, Takemoto T, Nakai M, Fuchimoto DI, Otoi T 2019

[雑誌論文] Hoxa13 regulates expression of common Hox target genes involved in cartilage development to coordinate the expansion of the autopodal anlage

Yamamoto S, Uchida Y, Ohtani T, Nozaki E, Yin C, Gotoh Y, Yakushiji‐Kaminatsui N, Higashiyama T, Suzuki T, Takemoto T, Shiraishi Y, Kuroiwa A. 2019

[雑誌論文] Restriction of PD-1 function by cis-PD-L1/CD80 interactions is required for optimal T cell responses

Sugiura D, Maruhashi T, Okazaki I, Shimizu K, Maeda T, Takemoto T, Okazaki T. 2019

[学会発表] “Singularity Biology : small elements change the function of the systems”

Kazuki Horikawa 2019

[学会発表] 大規模イメージングで明らかになった、cAMP信号波の螺旋コア形成機構

堀川一樹 2019

[雑誌論文] Effects of voltage strength during electroporation on the development and quality of in vitro-produced porcine embryos

Nishio K, Tanihara F, Nguyen TV, Kunihara T, Nii M, Hirata M, Takemoto T, Otoi T 2018

[雑誌論文] Generation of a TP53-modified porcine cancer model by CRISPR/Cas9-mediated gene modification in porcine zygotes via electroporation

Tanihara F, Hirata M, Nguyen NT, Le QA, Hirano T, Takemoto T, Nakai M, Fuchimoto DI, Otoi T 2018

[雑誌論文] Histone H3.3 sub-variant H3mm7 is required for normal skeletal muscle regeneration

Harada A, Maehara K, Ono Y, Taguchi H, Yoshioka K, Kitajima Y, Xie Y, Sato Y, Iwasaki T, “Nogami J, Okada S, Komatsu T, Semba Y, Takemoto T, Kimura H, Kurumizaka H, Ohkawa Y 2018

[雑誌論文] Cardiomyocytes cultured on mechanically compliant substrates, but not on conventional culture devices, exhibit prominent mitochondrial dysfunction due to reactive oxygen species and insulin resistance under high glucose

Morishima M, Horikawa K, Funaki M 2018

[図書] How Low Can You Go? The Numbers of Cells That Make Up Bodies: Large Numbers and Small Numbers, Minorities and Small Numbers from Molecules to Organisms in Biology-Toward a New Understanding of Biological Phenomena

Kazuki Horikawa 2018

[学会発表] Red fluorescent cAMP indicator with increased affinity and expanded dynamic range

Kazuki Horikawa 2018

[図書] 蛍光タンパク質ⅳ．cAMPプローブ, 生きてるものは全部観る！ イメージングの選び方・使い方100＋実験医学増刊 36 No.20

堀川一樹 2018