トップ研究者を探す胸腺におけるネオ・セルフ生成機構

胸腺におけるネオ・セルフ生成機構

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PLANNED-16H06496
研究種目 新学術領域研究(研究領域提案型)
研究分野
研究機関 徳島大学
代表研究者 松本 満
研究分担者 吉開 泰信
研究期間 開始年月日 2016/4/1
研究期間 終了年度 2020
研究ステータス 完了 (2021/4/1)
配分額(合計) 201,110,000 (直接経費 :154,700,000、間接経費 :46,410,000)
配分額(履歴) 2020年度:38,870,000 (直接経費 :29,900,000、間接経費 :8,970,000)
2019年度:38,870,000 (直接経費 :29,900,000、間接経費 :8,970,000)
2018年度:38,870,000 (直接経費 :29,900,000、間接経費 :8,970,000)
2017年度:38,870,000 (直接経費 :29,900,000、間接経費 :8,970,000)
2016年度:45,630,000 (直接経費 :35,100,000、間接経費 :10,530,000)
キーワード 胸腺
自己免疫疾患
Aire
innate T細胞
ネオ・セルフ
免疫学的自己
Vγ6+γδTh17細胞
自然T細胞
抗原提示細胞
innate T cell
胸腺上皮細胞
抗原認識機構
自己抗原
自己寛容
自然免疫T細胞

研究成果

[学会発表] 胸腺内Treg誘導における胸腺髄質上皮細胞と樹状細胞の機能的差異

森本 純子、松本 満 2022

[図書] Transcriptomics in Health and Disease

Hideyuki Yoshida, Mitsuru Matsumoto, and Minoru Matsumoto 2022

[学会発表] 胸腺癌におけるAIRE発現と胸腺髄質上皮細胞との類似性

松本 穣、松本 満、尾矢剛志 2022

[学会発表] Aire suppresses CTLA-4 expression from medullary thymic epithelial cells to avoid autoimmunity

Junko Morimoto , Minoru Matsumoto , Ryuichiro Miyazawa , Hideyuki Yoshida , Mitsuru Matsumoto. 2021

[雑誌論文] 胸腺髄質上皮細胞における組織特異的自己抗原の発現と負の選択

松本 穣、宮澤龍一郎、森本純子、尾矢剛志、松本 満 2021

[雑誌論文] Development of a new monoclonal antibody specific to the murine Vγ6 chain.

Hatano S, Tun X, Noguchi N, Yue D, Yamada H, Sun X, Matsumoto M, and Yoshikai Y. 2019

[学会発表] Development of IL-17A+ Vγ6 γδ T cells in mouse thymus

Shinya Hatano, Xin Tun, Mitsuru Matsumoto, Yoshihiro Baba, Yasunobu Yoshikai. 2019

[学会発表] 胸腺髄質上皮細胞に発現する転写調節因子Aireを用いた自己免疫病態の解析

松本 満 2019

[学会発表] 胸腺におけるネオ・セルフ生成機構

松本 満 2019

[学会発表] Characterization of Aire-expressing DCs with a high-sensitivity and high-fidelity Aire-reporter strain Minoru Matsumoto, Hitoshi Nishijima, Ryuichiro Miyazawa, Junko Morimoto, Koichi Tsuneyama, Mitsuru Matsumoto

Minoru Matsumoto, Hitoshi Nishijima, Ryuichiro Miyazawa, Junko Morimoto, Koichi Tsuneyama, Mitsuru Matsumoto 2019

[学会発表] Aire-dependent establishment of self-tolerance

Matsumoto M, Morimoto J, Matsumoto M, Tsuneyama K, Miyazawa R, Nishijima H 2019

[学会発表] The analysis of roles of Vγ6 γδ T cells in host defense using a new monoclonal antibody specific to mouse Vγ6 chain

Shinya Hatano, Xin Tun, Dan Yue, Naoto Noguchi, Xun Sun, Mitsuru Matsumoto, Yasunobu Yoshikai. 2019

[雑誌論文] ヒトAIREを発現させたNODマウスに認められる自己免疫応答

西嶋 仁、松本 満 2019

[学会発表] Aireを高発現する胸腺髄質上皮細胞の免疫学的機能とトランスクリプトーム解析

西嶋 仁、杉田瑞季、森本純子、松本 穣、松本 満 2019

[学会発表] Tissue-specific autoimmunity controlled by Aire in thymic and peripheral tolerance mechanisms

Minoru Matsumoto, Mitsuru Matsumoto 2019

[図書] Thymus Transcriptome and Cell Biology

Minoru Matsumoto, Pedro M. Rodrigues, Laura Sousa, Koichi Tsuneyama, Mitsuru Matsumoto, Nuno L. Alves 2019

[学会発表] Aire-dependent establishment of self-tolerance studied by genetically modified mice

Mitsuru Matsumoto, Junko Morimoto, Minoru Matsumoto, Koichi Tsuneyama, Ryuichiro Miyazawa, Hitoshi Nishijima 2019

[学会発表] Antigen transfer from thymic epithelial cells to DCs contributes to the production of thymic Tregs

Junko Morimoto, Hitoshi Nishijima, Minoru Matsumoto, Mitsuru Matsumoto 2019

[雑誌論文] Fas/FasL signaling is critical for the survival of exhausted antigen-specific CD8+ T cells during tumor immune response.

Yajima T, Hoshino K, Muranushi R, Mogi A, Onozato R, Yamaki E, Kosaka T, Tanaka S, Shirabe K, Yoshikai Y and Kuwano H. 2019

[学会発表] Aire-dependent subset of mTECs with tolerogenic functions is defined by Ly6 family protein expression.

Mitsuru Matsumoto, Junko Morimoto, Minoru Matsumoto, Koichi Tsuneyama, Hitoshi Nishijima 2018

[学会発表] Acquisition of the resistance to autoimmune diabetes by the expression of human AIRE in BM-derived APCs in NOD

Minoru Matsumoto, Hitoshi Nishijima, Junko Morimoto, Koichi Tsuneyama, Mitsuru Matsumoto 2018

[学会発表] Amelioration of diabetes development in NOD by the transgenic human AIRE expression in DCs

Mitsuru Matsumoto 2018

[学会発表] Expression of Ly6C/6G defines a novel subset of medullary thymic epithelial cells

Junko Morimoto, Yumiko Nishikawa, Naoki Kihara, Kazuyoshi Hosomichi, Hitoshi Nishijima, Mitsuru Matsumoto 2018

[学会発表] Manipulation of thymic and peripheral tolerance by AIRE defines distinct tissue-specific autoimmunity

Minoru Matsumoto, Hitoshi Nishijima, Junko Morimoto, Koichi Tsuneyama and Mitsuru Matsumoto 2018

[学会発表] Paradoxical development of polymyositis-like autoimmunity through augmented expression of AIRE

Nishijima, H., Mouri, Y., Morimoto, J., Matsumoto, M. 2017

[学会発表] Tissue-specific autoimmune response controlled by Aire.

Mitsuru Matsumoto 2017

[学会発表] Expression of Ly6C/6G defines a novel Aire-dependent subset of medullary thymic epithelial cells with tolerogenic function

Morimoto, J., Nishikawa, Y., Nishijima, H., Matsumoto, M. 2017

[学会発表] Paradoxical development of polymyositis-like autoimmunity through augmented expression of human AIRE in mice

Nishijima, H., Mouri, Y., Morimoto, J., Matsumoto, M. 2017

[学会発表] Expression of Ly6C/6G defines a novel subset of medullary thymic epithelial cells.

Junko Morimoto, Yumiko Nishikawa, Naoki Kihara, Kazuyoshi Hosomichi, Hitoshi Nishijima, Mitsuru Matsumoto 2017

[学会発表] Massive infiltration of macrophages and eosinophils in the muscle of mice overexpressing Aire in thymic and peripheral antigen-presenting cells

Nishijima, H., Matsumoto, M. 2016

[学会発表] Immunological tolerance mediated by Aire

Matsumoto, M. 2016