研究成果

[雑誌論文] Generation of diversity in thymic epithelial cells.

Takahama Y, Ohigashi I, Baik S, Anderson G. 2017

[雑誌論文] Foxn1-β5t transcriptional axis controls CD8+ T cell production in the thymus.

Uddin MM, Ohigashi I, Motosugi R, Nakayama T, Sakata M, Hamazaki J, Nishito Y, Rode I, Tanaka K, Takemoto T, Murata S, Takahama Y. 2017

[雑誌論文] Generation of peptides that promote positive selection in the thymus.

Takada K, Kondo K, Takahama Y. 2017

[学会発表] cTEC-dependent positive selection of CD8 T cells

Yousuke Takahama 2017

[雑誌論文] Dynamic spatio-temporal contribution of single β5t+ cortical epithelial precursors to the thymus medulla

Mayer CE, Zuklys S, Zhanybekova S, Ohigashi I, Teh HY, Sansom SN, Shikama-Dorn N, Hafen K, Macaulay IC, Deadman ME, Ponting CP, Takahama Y, Hollander GA. 2016

[雑誌論文] Development and developmental potential of cortical thymic epithelial cells.

Ohigashi I, Kozai M, Takahama Y. 2016

[図書] Synthetic Immunology

渡邊武、高濱洋介 2016

[雑誌論文] TCR affinity for thymoproteasome-dependent positively selecting peptides conditions antigen responsiveness in CD8+ T cells


Takada K, Van Laethem F, Xing Y, Akane K, Suzuki H, Murata S, Tanaka K, Jameson SC, Singer A, Takahama Y. 2016

[学会発表] T cell development and selection in the thymus

高濱洋介 2016

[学会発表] How the thymic medulla attracts thymocytes for the establishment of self-tolerance

高濱 洋介 2016

[学会発表] Thymic microenvironments that form T cell repertoire

高濱洋介 2015

[学会発表] T cell formation in thymus microenvironments

高濱洋介 2015

[学会発表] Cell-cell interactions in the thymus

高濱洋介 2015

[学会発表] Thymus-dependent positive selection of T cells

高濱洋介 2015

[雑誌論文] Gimap3 and Gimap5 cooperate to maintain T-cell numbers in the mouse.,

Kouta Yano, Christine Carter, Naofumi Yoshida, Takaya Abe, Akiko Yamada, Takeshi Nitta, Naozumi Ishimaru, Kensuke Takada, W Geoffrey Butcher and Yousuke Takahama : 2014

[雑誌論文] A novel CD3-specific antibody induces immunosuppression via impaired phosphorylation of LAT and PLCγ1 following T-cell stimulation.

Shiheido H, Aoyama　T,　Takahashi　H,　Hanaoka　K,　Abe　T,　Nishida　E,　Chen　C,　Koga　O,　Hikida　M,　Shibagaki　Y, Morita A, Nikawa T, Hattori S, Watanabe T, Shimizu J. 2014

[雑誌論文] A novel CD3-specific antibody induces immunosuppression via impaired phosphorylation of LAT and PLCγ1 following T-cell stimulation

Shiheido H, Aoyama T, Takahashi H, Hanaoka K, Abe T, Nishida E, Chen C, Koga O, Hikida M, Shibagaki Y, Morita A, Nikawa T, Hattori S, Watanabe T, Shimizu J. 2014

[雑誌論文] Characterization of the interleukin-15 niche in primary and secondary lymphoid organs in vivo.

Cui G, Hara T, Simmons S, Wagatsuma K, Abe A, Miyachi H, Kitano S, Ishii M, Tani-ichi S, Ikuta K. 2014

[雑誌論文] Environments of B cell development.

Tsuneto M, Kajikhina E, Seiler K, Reimer A, Tornack J, Bouquet C, Simmons S, Knoll M, Wolf I, Tokoyoda K, Hauser A, Hara T, Tani-Ichi S, Ikuta K, Grun J. R, Grutzkau A, Engels N, Wienands J, Yanagisawa Y, Ohnishi K , Melchers F. 2014

[雑誌論文] Interleukin-7 produced by thymic epithelial cells plays a major role in the development of thymocytes and TCRγδ+ intraepithelial lymphocytes.

Shitara S, Hara T, Liang B, Wagatsuma K, Zuklys S, Hollander GA, Nakase H, Chiba T, Tani-ichi S, Ikuta K. 2013

[雑誌論文] B cell progenitors and precursors change their microenvironment in fetal liver during early development.

Tsuneto M, Tokoyoda K, Kajikhina E, Hauser AE, Hara T, Tani-ichi S, Ikuta K, Melchers F. 2013