トップ›研究者を探す›ネオ・セルフの生成・機能・構造に対する国際活動支援

ネオ・セルフの生成・機能・構造に対する国際活動支援

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-INTERNATIONAL-16K21731
研究種目 新学術領域研究(研究領域提案型)
研究分野
研究機関 徳島大学
代表研究者 松本 満
研究分担者 横須賀 忠
研究期間 開始年月日 2016/4/1
研究期間 終了年度 2022
研究ステータス 完了 (2022/4/1)
配分額（合計） 28,990,000 (直接経費 :22,300,000、間接経費 :6,690,000)
配分額（履歴） 2020年度：8,060,000 (直接経費 :6,200,000、間接経費 :1,860,000)
2019年度：4,810,000 (直接経費 :3,700,000、間接経費 :1,110,000)
2018年度：8,060,000 (直接経費 :6,200,000、間接経費 :1,860,000)
2017年度：4,810,000 (直接経費 :3,700,000、間接経費 :1,110,000)
2016年度：3,250,000 (直接経費 :2,500,000、間接経費 :750,000)
キーワード ネオ・セルフ
国際活動支援
免疫学的自己
国際共同研究
バイオリソース
HLA
T細胞抗原受容体
免疫認識機構
国際研究協力

研究成果

[学会発表] Aire suppresses CTLA-4 expression from medullary thymic epithelial cells to avoid autoimmunity

Junko Morimoto, Mitsuru Matsumoto 2023

[図書] Transcriptomics in Health and Disease

Hideyuki Yoshida, Mitsuru Matsumoto, Minoru Matsumoto 2022

[学会発表] 胸腺癌におけるAIRE発現と胸腺髄質上皮細胞との類似性

松本　穣、松本　満、尾矢剛志 2022

[学会発表] 胸腺内Treg誘導における胸腺髄質上皮細胞と樹状細胞の機能的差異

森本　純子、松本　満 2022

[学会発表] Elucidation of the pathogenesis of autoimmune disease: from serology toward molecular biology

Mitsuru Matsumoto 2022

[学会発表] Autoimmune pathology caused by the abnormal function of thymic epithelial cells

Mitsuru Matsumoto 2022

[学会発表] Tissue-specific autoimmunity controlled by Aire, a gene response for APECED

Minoru Matsumoto, Hitoshi Nishijima, Junko Morimoto, Koichi Tsuneyama, Mitsuru Matsumoto 2021

[学会発表] 胸腺髄質上皮細胞からDCへの抗原転移におけるAireの役割

森本　純子、松本　満 2021

[学会発表] Aireレポーターマウスを用いた胸腺内Aire発現樹状細胞の解析

松本　穣、尾矢剛志、松本　満 2021

[雑誌論文] Aberrant type 1 immunity drives susceptibility to mucosal fungal infection

T Break, V Oikonomou, N Dutzan, J Desai, M Swidergall, T Freiwald, D Chauss, O Harrison, J Alejo, D Williams, S Pittaluga, C-C Lee, N Bouladoux, M Swamydas, K Hoffman, T Greenwell-Wild, V Bruno, L Rosen, W Lwin, A Renteria, S Pontejo, J Shannon, I Myles, P Olbrich, E Ferre, M Schmitt, D Martin, M Matsumoto, et al. 2021

[学会発表] Aire suppresses CTLA-4 expression from medullary thymic epithelial cells to avoid autoimmunity

Junko Morimoto , Minoru Matsumoto , Ryuichiro Miyazawa , Hideyuki Yoshida , Mitsuru Matsumoto 2021

[雑誌論文] Aireを基軸とする自己免疫疾患の病態解明

森本純子、宮澤龍一郎、松本　穣、松本　満 2020

[雑誌論文] 胸腺上皮細胞を対象とする自己免疫疾患への橋渡し研究の可能性

森本純子、松本　穣、宮澤龍一郎、松本　満 2020

[図書] Thymus Transcriptome and Cell Biology

Minoru Matsumoto, Pedro M. Rodrigues, Laura Sousa, Koichi Tsuneyama, Mitsuru Matsumoto, Nuno L. Alves. 2019

[雑誌論文] Development of a new monoclonal antibody specific to mouse Vg6 chain

Hatano S, Tun X, Noguchi N, Yue D, Yamada H, Sun X, Matsumoto M, Yoshikai Y. 2019

[学会発表] Characterization of Aire-expressing DCs with a high-sensitivity and high-fidelity Aire-reporter strain

Minoru Matsumoto, Hitoshi Nishijima, Ryuichiro Miyazawa, Junko Morimoto, Koichi Tsuneyama, Mitsuru Matsumoto 2019

[学会発表] Antigen transfer from thymic epithelial cells to DCs contributes to the production of thymic Tregs

Junko Morimoto, Hitoshi Nishijima, Minoru Matsumoto, Mitsuru Matsumoto 2019

[学会発表] Aire-dependent establishment of self-tolerance studied by genetically modified mice

Mitsuru Matsumoto, Junko Morimoto, Minoru Matsumoto, Koichi Tsuneyama, Ryuichiro Miyazawa, Hitoshi Nishijima 2019

[学会発表] Tissue-specific autoimmunity controlled by Aire in thymic and peripheral tolerance mechanisms

Minoru Matsumoto, Mitsuru Matsumoto 2019

[学会発表] Aireを高発現する胸腺髄質上皮細胞の免疫学的機能とトランスクリプトーム解析

西嶋　仁、杉田瑞季、森本純子、松本　穣、松本　満 2019

[学会発表] Aire-dependent establishment of self-tolerance

Matsumoto M, Morimoto J, Matsumoto M, Tsuneyama K, Miyazawa R, Nishijima H 2019

[雑誌論文] ヒトAIREを発現させたNODマウスに認められる自己免疫応答

西嶋　仁、松本　満 2019

[学会発表] 腺髄質上皮細胞に発現する転写調節因子Aireを用いた自己免疫病態の解析

松本　満 2019

[学会発表] 胸腺におけるネオ・セルフ生成機構

松本　満 2019

[学会発表] Aire-dependent subset of mTECs with tolerogenic functions is defined by Ly6 family protein expression.

Mitsuru Matsumoto, Junko Morimoto, Minoru Matsumoto, Koichi Tsuneyama, Hitoshi Nishijima 2018

[学会発表] Acquisition of the resistance to autoimmune diabetes by the expression of human AIRE in BM-derived APCs in NOD

Minoru Matsumoto, Hitoshi Nishijima, Junko Morimoto, Koichi Tsuneyama, Mitsuru Matsumoto 2018

[雑誌論文] Paradoxical development of polymyositis-like autoimmunity through augmented expression of autoimmune regulator (AIRE)

Nishijima Hitoshi、Kajimoto Tatsuya、Matsuoka Yoshiki、Mouri Yasuhiro、Morimoto Junko、Matsumoto Minoru、Kawano Hiroshi、Nishioka Yasuhiko、Uehara Hisanori、Izumi Keisuke、Tsuneyama Koichi、Okazaki Il-mi、Okazaki Taku、Hosomichi Kazuyoshi、Shiraki Ayako、Shibutani Makoto、Mitsumori Kunitoshi、Matsumoto Mitsuru 2018

[学会発表] Expression of Ly6C/6G defines a novel subset of medullary thymic epithelial cells

Junko Morimoto, Yumiko Nishikawa, Naoki Kihara, Kazuyoshi Hosomichi, Hitoshi Nishijima, Mitsuru Matsumoto 2018

[雑誌論文] Aire Controls in Trans the Production of Medullary Thymic Epithelial Cells Expressing Ly-6C/Ly6G

Junko Morimoto, Yumiko Nishikawa, Takumi Kakimoto, Kohei Furutani, Naoki Kihara, Minoru Matsumoto, Koichi Tsuneyama, Yuko Kozono, Haruo Kozono, Katsuto Hozumi, Kazuyoshi Hosomichi, Hitoshi Nishijima and Mitsuru Matsumoto 2018

[学会発表] Manipulation of thymic and peripheral tolerance by AIRE defines distinct tissue-specific autoimmunity

Minoru Matsumoto, Hitoshi Nishijima, Junko Morimoto, Koichi Tsuneyama and Mitsuru Matsumoto 2018

[学会発表] Amelioration of diabetes development in NOD by the transgenic human AIRE expression in DCs

Mitsuru Matsumoto 2018

[学会発表] Tissue-specific autoimmune response controlled by Aire.

Mitsuru Matsumoto 2017

[学会発表] Paradoxical development of polymyositis-like autoimmunity through augmented expression of AIRE

Nishijima, H., Mouri, Y., Morimoto, J., Matsumoto, M. 2017

[学会発表] Expression of Ly6C/6G defines a novel Aire-dependent subset of medullary thymic epithelial cells with tolerogenic function

Morimoto, J., Nishikawa, Y., Nishijima, H., Matsumoto, M. 2017

[学会発表] Expression of Ly6C/6G defines a novel subset of medullary thymic epithelial cells.

Junko Morimoto, Yumiko Nishikawa, Naoki Kihara, Kazuyoshi Hosomichi, Hitoshi Nishijima, Mitsuru Matsumoto 2017

[学会発表] Paradoxical development of polymyositis-like autoimmunity through augmented expression of human AIRE in mice

Nishijima, H., Mouri, Y., Morimoto, J., Matsumoto, M. 2017

[学会発表] Immunological tolerance mediated by Aire

Matsumoto, M. 2016

[学会発表] Possible defect in the Treg production in mice overexpressing AIRE/Aire which exhibit muscle-specific autoimmunity

Nishijima, H., Matsuoka, Y., Mouri, Y., Morimoto, J., Matsumoto, M. 2016

[学会発表] Massive infiltration of macrophages and eosinophils in the muscle of mice overexpressing Aire in thymic and peripheral antigen-presenting cells

Nishijima, H., Matsumoto, M. 2016