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北村直也

徳島大学

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2024年11月22日更新

職名: 教授
電話: 研究者総覧に該当データはありませんでした。
電子メール: nkitamura@tokushima-u.ac.jp
学歴: 研究者総覧に該当データはありませんでした。
学位: 博士(歯学) (広島大学大学院歯学研究科歯学臨床系(口腔外科学第一専攻)) (2002年3月)
職歴・経歴: 2024/1: 徳島大学教授, 大学院医歯薬学研究部

専門分野・研究分野: 歯学 (Dentistry)
ライフサイエンス
外科系歯学 (Oral and Maxillofacial Surgery)

研究者総覧で最新データを確認する

2024年11月22日更新

専門分野・研究分野: 歯学 (Dentistry)
ライフサイエンス
外科系歯学 (Oral and Maxillofacial Surgery)
担当経験のある授業科目: SIH道場~アクティブ・ラーニング入門~(歯学部) (共通教育)
医の倫理と安全管理 (学部)
医療コミュニケーション (学部)
口腔と健康 (共通教育)
口腔感染症学 (大学院)
口腔管理学 (大学院)
口腔管理学演習 (大学院)
外科系歯科学 (学部)
実践口腔科学実習 (大学院)
高齢者歯科学実験実習 (大学院)
指導経験: 研究者総覧に該当データはありませんでした。

研究者総覧で最新データを確認する

2024年11月22日更新

専門分野・研究分野: 歯学 (Dentistry)
ライフサイエンス
外科系歯学 (Oral and Maxillofacial Surgery)

研究テーマ: (ウイローム, マイクロバイオーム, バクテリオファージ (bacteriophage), 腫瘍ウイルス, 口腔癌, 口腔外科学)

著書

北村直也 :
口腔癌診療ガイドライン 2023年度版, --- 術前化学療法 ---,
金原出版株式会社, 東京, 2023年11月.

論文

Naoya Kitamura, Munefumi Kamamoto, Takeharu Ikoma, Daisuke Takeda, Taiki Suzuki, Haruki Sato, Seiji Asoda, Masatoshi Adachi, Hidemichi Yuasa, Narikazu Uzawa and Hiroshi Kurita :
Efficacy and safety of neoadjuvant chemotherapy in resectable oral squamous cell carcinomas: A systematic review and meta-analysis,
Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, Vol.36, No.3, 266-272, 2024.

(キーワード): Neoadjuvant chemotherapy / Resectable oral squamous cell carcinoma / Oral cancer / Systematic review / Meta-analysis
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.ajoms.2023.08.011
(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-85169049285

(DOI: 10.1016/j.ajoms.2023.08.011, Elsevier: Scopus) Yoji Nakase, Atsuko Hamada, Fumitaka Obayashi, Naoya Kitamura, Tsuyoshi Hata, Tetsuya Yamamoto and Tetsuji Okamoto :
Establishment of induced pluripotent stem cells derived from patients and healthy siblings of a nevoid basal cell carcinoma syndrome family,
In Vitro Cellular & Developmental Biology. Animal, Vol.59, No.6, 395-400, 2023.

(要約): It is known that a nevoid basal cell carcinoma syndrome (NBCCS) is characterized by a combination of developmental abnormalities and a predisposition to form various tumors. Although it is possible to create disease models via gene editing, there are significant potential problems with this approach such as off-target mutations and differences in SNPs. On the other hand, since disease families share common SNPs, research using iPSCs derived from both patients and healthy siblings of the same disease family is very important. Thus, establishment of induced pluripotent stem cells derived from patients and healthy siblings of the same NBCCS family will be of great importance to study the etiology of this disease and to develop therapeutics. In this study, we generated hiPSCs using peripheral blood mononuclear cells derived from the patients and healthy siblings of familial NBCCS with the novel mutation in PTCH1_c.3298_3299insAAG in the feeder- and serum-free culture conditions using SeVdp. In addition, disease-specific hiPSCs such as those expressing the PTCH1_c.3298_3299insAAG mutation could be powerful tools for revealing the genotype-phenotype relationship and pathogenicity of NBCCS.
(キーワード): Animals / Humans / Basal Cell Nevus Syndrome / 人工多能性幹細胞 (induced pluripotent stem cells) / Siblings / Leukocytes, Mononuclear / Mutation
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s11626-023-00778-y
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37460876; ● Summary page in Scopus @ Elsevier: 2-s2.0-85164948928

(DOI: 10.1007/s11626-023-00778-y, PubMed: 37460876, Elsevier: Scopus) Naoya Kitamura, Yumiko Hashida, Tomonori Higuchi, Seiji Ohno, Shinya Sento, Eri Sasabe, Ichiro Murakami, Tetsuya Yamamoto and Masanori Daibata :
Detection of Merkel cell polyomavirus in multiple primary oral squamous cell carcinomas,
Odontology, Vol.111, No.4, 971-981, 2023.

(要約): Oral microbiome studies have mainly focussed on bacteria, with the relationship between viruses and oral cancers remaining poorly understood. Oral cancers can develop even in the absence of any history of daily smoking or drinking. Oral cancer patients frequently have multiple primary cancers in the oral cavity and other organs, such as the upper gastrointestinal tract. Merkel cell polyomavirus (MCPyV) is a novel oncovirus identified from a subtype of skin cancer in 2008. In this study, we investigated the potential involvement of MCPyV in the pathogenesis of oral squamous cell carcinoma (OSCC). Participants comprised 115 Japanese patients with OSCC (single primary: 109 tumours in 109 patients; multiple primaries: 16 tumours in 6 patients) treated in our department between 2014 and 2017. DNA was extracted from formalin-fixed paraffin-embedded specimens of primary lesions. MCPyV DNA copy counts were analysed by quantitative real-time polymerase chain reaction. Twenty-four of the 115 patients (20.9%) were positive for MCPyV DNA. No association was found between presence or absence of MCPyV DNA and clinical characteristics other than number of primary lesions. The MCPyV DNA-positive rate was significantly higher for multiple primary OSCCs (62.5%, 10/16 tumours) than for single primary OSCCs (16.5%, 18/109 tumours; P < 0.001). Furthermore, MCPyV DNA load was significantly higher for patients with multiple primaries (P < 0.05). MCPyV was observed more frequently and DNA load was significantly higher with multiple primary OSCCs than with single primary OSCC. MCPyV may play some role as an oncovirus for multiple primary OSCCs.
(キーワード): Humans / Carcinoma, Squamous Cell / Merkel cell polyomavirus / Squamous Cell Carcinoma of Head and Neck / Polyomavirus Infections / DNA, Viral / Mouth Neoplasms / Head and Neck Neoplasms / Neoplasms, Multiple Primary
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s10266-023-00807-y
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36964865; ● Summary page in Scopus @ Elsevier: 2-s2.0-85150729178

(DOI: 10.1007/s10266-023-00807-y, PubMed: 36964865, Elsevier: Scopus) Satoru Kisoda, Yasuhiro Mouri, Naoya Kitamura, Tetsuya Yamamoto, Keiko Miyoshi and Yasusei Kudo :
The role of partial-EMT in the progression of head and neck squamous cell carcinoma.,
Journal of Oral Biosciences, Vol.64, No.2, 176-182, 2022.

(要約): In this review, we highlight the features of partial-EMT in HNSCC by summarizing previous studies. Moreover, we discuss the therapeutic potential for targeting partial-EMT.
(キーワード): Carcinoma, Squamous Cell / Epithelial-Mesenchymal Transition / Head and Neck Neoplasms / Humans / Lymphatic Metastasis / Squamous Cell Carcinoma of Head and Neck
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.job.2022.02.004
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35176487; ● Summary page in Scopus @ Elsevier: 2-s2.0-85125440565

(DOI: 10.1016/j.job.2022.02.004, PubMed: 35176487, Elsevier: Scopus) Eri Sasabe, Ayumi Tomomura, Hangyu Liu, Shinya Sento, Naoya Kitamura and Tetsuya Yamamoto :
Epidermal growth factor/epidermal growth factor receptor signaling blockage inhibits tumor cell-derived exosome uptake by oral squamous cell carcinoma through macropinocytosis,
Cancer Science, Vol.113, No.2, 609-621, 2022.

(要約): Various cell types secrete exosomes into their surrounding extracellular space, which consequently affect the function and activity of recipient cells. Numerous studies have showed that tumor cell-derived exosomes play important roles in tumor growth and progression. Although a variety of endocytic pathways are reportedly involved in the cellular uptake of exosomes, detailed mechanisms remain unknown. The present study demonstrated that treatment with recombinant epidermal growth factor (EGF) time- and dose-dependently promoted cellular uptake of oral squamous cell carcinoma (OSCC) cell-derived exosomes into OSCC cells themselves. Conversely, EGF receptor (EGFR) knockdown and treatment with EGFR inhibitors, including erlotinib and cetuximab, abrogated OSCC cell uptake of exosomes. The macropinocytosis inhibitor 5-(N-ethyl-N-isopropyl) amiloride (EIPA) blocked the effects of active EGF/EGFR signaling on uptake of OSCC cell-derived exosomes. These EGFR inhibitors also suppressed OSCC cell-derived exosome-induced proliferation, migration, invasion, stemness, and chemoresistance of OSCC cells. Taken together, the data presented herein suggest that EGFR inhibitors might inhibit the malignant potential of OSCC cells through direct inhibition of not only EGFR downstream signaling pathway but also cellular uptake of OSCC cell-derived exosomes through macropinocytosis.
(キーワード): Cell Line, Tumor / Cell Movement / Cell Proliferation / Drug Resistance, Neoplasm / Epidermal Growth Factor / ErbB Receptors / Exosomes / Humans / Mouth Neoplasms / Neoplastic Stem Cells / Pinocytosis / Protein Kinase Inhibitors / シグナル伝達 (signal transduction) / Squamous Cell Carcinoma of Head and Neck
(出版サイトへのリンク): ● Publication site (DOI): 10.1111/cas.15225
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34874595; ● Summary page in Scopus @ Elsevier: 2-s2.0-85121383395

(DOI: 10.1111/cas.15225, PubMed: 34874595, Elsevier: Scopus) Tomohiro Nishimori, Tomonori Higuchi, Yumiko Hashida, Takako Ujihara, Ayuko Taniguchi, Fumiya Ogasawara, Naoya Kitamura, Ichiro Murakami, Kensuke Kojima and Masanori Daibata :
Development of a novel cell line-derived xenograft model of primary herpesvirus 8-unrelated effusion large B-cell lymphoma and antitumor activity of birabresib in vitro and in vivo,
Cancer Medicine, Vol.10, No.24, 8976-8987, 2021.

(要約): Primary human herpesvirus 8 (HHV8)-unrelated effusion large B-cell lymphoma is a clinical disease entity distinct from HHV8-positive primary effusion lymphoma (PEL). However, the lack of experimental HHV8-unrelated effusion large B-cell lymphoma models continues to hinder the pathophysiologic and therapeutic investigations of this disorder. The lymphoma cells were obtained from the pleural effusion of a patient with primary HHV8-unrelated effusion large B-cell lymphoma and cultured in vitro. We established a novel HHV8-unrelated effusion large B-cell lymphoma cell line, designated Pell-1, carrying a c-MYC rearrangement with features distinct from those of HHV8-positive PEL. Moreover, we developed an HHV8-unrelated effusion large B-cell lymphoma cell line-derived xenograft model. Pell-1 cells induced profuse lymphomatous ascites and subsequently formed intra-abdominal tumors after intraperitoneal implantation into irradiated nonobese diabetic/severe combined immunodeficient mice. Thus, this xenograft mouse model mimicked the clinical phenomena observed in patients and recapitulated the sequential stages of aggressive HHV8-unrelated effusion large B-cell lymphoma. The bromodomain and extraterminal domain (BET) inhibitors JQ1 and birabresib (MK-8628/OTX015) reduced the proliferation of Pell-1 cells in vitro through the induction of cell cycle arrest and apoptosis. The antitumor effect of BET inhibition was also demonstrated in vivo, as birabresib significantly reduced ascites and suppressed tumor progression without apparent adverse effects in the xenografted mice. These preclinical findings suggest the therapeutic potential of targeting c-MYC through BET inhibition in HHV8-unrelated effusion large B-cell lymphoma.
(キーワード): Acetanilides / Aged / Animals / Antineoplastic Agents / Disease Models, Animal / Herpesvirus 8, Human / Heterocyclic Compounds, 3-Ring / Humans / Lymphoma, Large B-Cell, Diffuse / Male / Mice / Mice, Inbred NOD / Proteins / Xenograft Model Antitumor Assays
(出版サイトへのリンク): ● Publication site (DOI): 10.1002/cam4.4394
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34821060; ● Summary page in Scopus @ Elsevier: 2-s2.0-85120554908

(DOI: 10.1002/cam4.4394, PubMed: 34821060, Elsevier: Scopus) 大野清二, 北村直也, 笹部衣里, 山本哲也 :
慢性C型肝炎患者に生じた口腔扁平苔癬の臨床的検討,
日本口腔内科学会雑誌, Vol.27, No.2, 52-58, 2021年.

(キーワード): 口腔扁平苔癬 / C型肝炎ウイルス / 再燃 / 癌化 / oral lichen planus / hepatitis C virus / relapse / malignant transformation
(出版サイトへのリンク): ● Publication site (DOI): 10.6014/jjsom.27.52
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390011097096968832; ● Search Scopus @ Elsevier (DOI): 10.6014/jjsom.27.52

(DOI: 10.6014/jjsom.27.52, CiNii: 1390011097096968832) Naoya Kitamura, Eri Sasabe, Shinya Sento, Katsuhito Kiyasu, Kosuke Nakaji, Masanori Daibata and Tetsuya Yamamoto :
Vertebral fracture and splenomegaly in a head and neck cancer producing granulocyte colony-stimulating factor: A case report of systemic complications associated with a cytokine-producing solid tumor,
Molecular and Clinical Oncology, Vol.15, No.4, 202, 2021.

(要約): Granulocyte colony-stimulating factor (G-CSF)-producing tumors are rare and are associated with a poor prognosis when they occur in the lungs and the head and neck region. Positron emission tomography/computed tomography has been reported to show systemic specific accumulation of fluorodeoxyglucose in these cases, but the systemic complications associated with the cytokines produced are not well known. We herein present the case of a G-CSF-producing maxillary sinus squamous cell carcinoma in a 73-year-old Japanese woman with a vertebral fracture and splenomegaly. These findings are known severe adverse events of high-dose recombinant human G-CSF treatment. The aim of the present study was to further discuss the hypothesis that cytokines produced by solid tumors may induce spinal vertebral fracture and splenomegaly.
(出版サイトへのリンク): ● Publication site (DOI): 10.3892/mco.2021.2364
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34462658; ● Summary page in Scopus @ Elsevier: 2-s2.0-85114711278

(DOI: 10.3892/mco.2021.2364, PubMed: 34462658, Elsevier: Scopus) 北村直也, 山本哲也 :
習慣性顎関節脱臼に対する外科療法,
日本口腔外科学会雑誌, Vol.67, No.3, 181-187, 2021年.

(キーワード): 習慣性顎関節脱臼 / 外科療法 / 超高齢化社会 / 関節結節削除術
(出版サイトへのリンク): ● Publication site (DOI): 10.5794/jjoms.67.181
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390569557085366272; ● Search Scopus @ Elsevier (DOI): 10.5794/jjoms.67.181

(DOI: 10.5794/jjoms.67.181, CiNii: 1390569557085366272) 吉澤泰昌, 北村直也, 山本哲也 :
治療関連骨髄異形成症候群を発症した頬粘膜癌の1例,
日本口腔腫瘍学会誌, Vol.33, No.1, 19-27, 2021年.

(キーワード): 治療関連骨髄異形成症候群 / 化学放射線療法 / アザシチジン / 口腔癌
(出版サイトへのリンク): ● Publication site (DOI): 10.5843/jsot.33.19
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390287441186669696; ● Search Scopus @ Elsevier (DOI): 10.5843/jsot.33.19

(DOI: 10.5843/jsot.33.19, CiNii: 1390287441186669696) Naoya Kitamura, Shinya Sento, Yasumasa Yoshizawa, Eri Sasabe, Yasusei Kudo and Tetsuya Yamamoto :
Current Trends and Future Prospects of Molecular Targeted Therapy in Head and Neck Squamous Cell Carcinoma.,
International Journal of Molecular Sciences, Vol.22, No.1, 240, 2020.

(要約): In recent years, advances in drug therapy for head and neck squamous cell carcinoma (HNSCC) have progressed rapidly. In addition to cytotoxic anti-cancer agents such as platinum-based drug (cisplatin and carboplatin) and taxane-based drugs (docetaxel and paclitaxel), epidermal growth factor receptor-tyrosine kinase inhibitors (cetuximab) and immune checkpoint inhibitors such as anti-programmed cell death-1 (PD-1) antibodies (nivolumab and pembrolizumab) have come to be used. The importance of anti-cancer drug therapy is increasing year by year. Therefore, we summarize clinical trials of molecular targeted therapy and biomarkers in HNSCC from previous studies. Here we show the current trends and future prospects of molecular targeted therapy in HNSCC.
(キーワード): Algorithms / Animals / Antineoplastic Agents / Antineoplastic Combined Chemotherapy Protocols / Biomarkers, Tumor / Clinical Decision-Making / Combined Modality Therapy / Disease Management / Epigenesis, Genetic / Gene Expression Regulation, Neoplastic / Humans / 免疫療法 (immunotherapy) / Molecular Diagnostic Techniques / Molecular Targeted Therapy / Phototherapy / Squamous Cell Carcinoma of Head and Neck
(徳島大学機関リポジトリ): ● Metadata: 119253
(出版サイトへのリンク): ● Publication site (DOI): 10.3390/ijms22010240
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33383632; ● Summary page in Scopus @ Elsevier: 2-s2.0-85098572994

(徳島大学機関リポジトリ: 119253, DOI: 10.3390/ijms22010240, PubMed: 33383632, Elsevier: Scopus) Yoji Nakase, Atsuko Hamada, Naoya Kitamura, Tsuyoshi Hata, Shigeaki Toratani, Tetsuya Yamamoto and Tetsuji Okamoto :
Novel PTCH1 mutations in Japanese familial nevoid basal cell carcinoma syndrome,
Human Genome Variation, Vol.7, No.1, 38, 2020.

(要約): Nevoid basal cell carcinoma syndrome (NBCCS), also known as Gorlin syndrome, is inherited in an autosomal dominant manner and is characterized by a combination of developmental abnormalities and a predisposition to tumor formation. Hedgehog receptor Patched 1 (PTCH1) has been identified as the mutated gene in NBCCS. We identified the PTCH1_c.3298_3299insAAG_p.1099_1100insE mutation in the transmembrane region, which comprises a sterol transporter whose abnormal function is reportedly related to pathogenicity.
(出版サイトへのリンク): ● Publication site (DOI): 10.1038/s41439-020-00126-6
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33298892; ● Summary page in Scopus @ Elsevier: 2-s2.0-85096239784

(DOI: 10.1038/s41439-020-00126-6, PubMed: 33298892, Elsevier: Scopus) Kharisma Perdani Kusumahstuti, Tadashi Watabe, Naoya Kitamura and Tetsuya Yamamoto :
Diffuse bone marrow uptake related to granulocyte colony-stimulating factor-producing maxillary sinus carcinoma on 4-borono-2-18F-fluoro-L-phenylalanine positron emission tomography/computed tomography,
World Journal of Nuclear Medicine, Vol.20, No.2, 188-191, 2020.

(要約): Granulocyte colony-stimulating factor (G-CSF) can be produced by tumor cells and is known to promote tumor growth, thereby potentially accelerating disease progression. Squamous cell carcinoma (SCC) at maxillary sinus is aggressive growth with poor prognosis. Maxillary sinus carcinomas are rare and can be clinically silent in the early stages or manifest with the same signs and symptoms of more common illnesses, leading to their delayed diagnosis of disease. Hypermetabolic uptake of F-fluorodeoxyglucose (F-FDG) but not of 4-borono-2-F-fluoro- L-phenylalanine (F-FBPA), in the bone marrow of patients with G-CSF-producing tumors without bone marrow involvement during positron emission tomography (PET), has been reported. The present case report describes our first experience of bone marrow uptake in PET/computed tomography examination usingF-FBPA, high uptake seen in the bone marrow of a patient with a G-CSF-secreting SCC of the maxillary sinus that it relapsed following chemoradiation therapy and surgical resection of the tumor.
(出版サイトへのリンク): ● Publication site (DOI): 10.4103/wjnm.WJNM_80_20
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34321973; ● Search Scopus @ Elsevier (PMID): 34321973; ● Search Scopus @ Elsevier (DOI): 10.4103/wjnm.WJNM_80_20

(DOI: 10.4103/wjnm.WJNM_80_20, PubMed: 34321973) Natsumi Fujiwara, Naoya Kitamura, Kaya Yoshida, Tetsuya Yamamoto, Kazumi Ozaki and Yasusei Kudo :
Involvement of Fusobacterium Species in Oral Cancer Progression: A Literature Review Including Other Types of Cancer,
International Journal of Molecular Sciences, Vol.21, No.17, 6207, 2020.

(要約): Chronic inflammation caused by infections has been suggested to be one of the most important cause of cancers. It has recently been shown that there is correlation between intestinal bacteria and cancer development including metastasis. As over 700 bacterial species exist in an oral cavity, it has been concerning that bacterial infection may cause oral cancer. However, the role of bacteria regarding tumorigenesis of oral cancer remains unclear. Several papers have shown that species deriving the oral cavities, especially, play a crucial role for the development of colorectal and esophageal cancer. is a well-known oral bacterium involved in formation of typical dental plaque on human teeth and causing periodontal diseases. The greatest characteristic of is its ability to adhere to various bacteria and host cells. Interestingly, is frequently detected in oral cancer tissues. Moreover, detection of is correlated with the clinical stage of oral cancer. Although the detailed mechanism is still unclear, species have been suggested to be associated with cell adhesion, tumorigenesis, epithelial-to-mesenchymal transition, inflammasomes, cell cycle, etc. in oral cancer. In this review, we introduce the reports focused on the association of species with cancer development and progression including oral, esophageal, and colon cancers.
(キーワード): Cell Adhesion / Colonic Neoplasms / Disease Progression / Epithelial-Mesenchymal Transition / Esophageal Neoplasms / Fusobacterium / Fusobacterium Infections / Humans / Inflammasomes / Mouth / Mouth Neoplasms
(徳島大学機関リポジトリ): ● Metadata: 115246
(出版サイトへのリンク): ● Publication site (DOI): 10.3390/ijms21176207
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32867334; ● Summary page in Scopus @ Elsevier: 2-s2.0-85090108629

(徳島大学機関リポジトリ: 115246, DOI: 10.3390/ijms21176207, PubMed: 32867334, Elsevier: Scopus) Naoya Kitamura, Eri Sasabe, Shigenobu Matsuzaki, Masanori Daibata and Tetsuya Yamamoto :
Characterization of two newly isolated Staphylococcus aureus bacteriophages from Japan belonging to the genus Silviavirus,
Archives of Virology, Vol.165, No.10, 2355-2359, 2020.

(要約): Two Staphylococcus aureus bacteriophages, KSAP7 and KSAP11, were isolated from sewage and characterized. Based on morphology and DNA sequences, they were assigned to the genus Silviavirus, subfamily Twortvirinae, family Herelleviridae, whose members are hypothesized to be suitable for bacteriophage therapy. The KSAP7 and KSAP11 genomes were 137,950 and 138,307 bp in size, respectively. Although their DNA sequences were almost identical, evidence of site-specific DNA rearrangements was found in two regions. Changes in the number of PIEPEK amino acid sequence repeats encoded by orf10 and the insertion/deletion of a 541-bp sequence that includes a possible tail-related gene were identified.
(キーワード): Amino Acid Sequence / Caudovirales / DNA, Viral / Gene Rearrangement / Genome Size / Genome, Viral / INDEL Mutation / 日本 (Japan) / Open Reading Frames / Phage Therapy / Phylogeny / Sequence Alignment / Staphylococcus Phages / Staphylococcus aureus
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s00705-020-04749-6
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32748178; ● Summary page in Scopus @ Elsevier: 2-s2.0-85088867484

(DOI: 10.1007/s00705-020-04749-6, PubMed: 32748178, Elsevier: Scopus) Riki Tomita, Naoya Kitamura, Yasumasa Yoshizawa, Eri Sasabe, Yasusei Kudo and Tetsuya Yamamoto :
A case of large varix including partially organizing thrombosis on the oral floor,
Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, Vol.32, No.4, 313-315, 2020.

(徳島大学機関リポジトリ): ● Metadata: 119394
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.ajoms.2020.03.003
(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-85084568277

(徳島大学機関リポジトリ: 119394, DOI: 10.1016/j.ajoms.2020.03.003, Elsevier: Scopus) Shinya Sento, Yasusei Kudo, Kenji Hibiya, Naozumi Ishimaru, Eri Sasabe, Naoya Kitamura and Tetsuya Yamamoto :
Hyalinizing clear cell carcinoma of the anterior lingual salivary gland: A case report and review of the literature,
Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, Vol.32, No.4, 267-274, 2020.

(徳島大学機関リポジトリ): ● Metadata: 119395
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.ajoms.2020.03.002
(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-85084530986

(徳島大学機関リポジトリ: 119395, DOI: 10.1016/j.ajoms.2020.03.002, Elsevier: Scopus) Naoya Kitamura, Shinya Sento, Yasumasa Yoshizawa, Eri Sasabe and Tetsuya Yamamoto :
Tongue necrosis caused by systemic vascular diseases: A systematic review of the literature,
Oral Science International, Vol.17, No.2, 2020.

(出版サイトへのリンク): ● Publication site (DOI): 10.1002/osi2.1054
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1002/osi2.1054

(DOI: 10.1002/osi2.1054) Y. Yoshizawa, R. Tomita, Naoya Kitamura and T. Yamamoto :
Two cases of medication-related osteonecrosis of the jaw with extension to the cranial base,
Oral Surgery, Vol.13, No.2, 147-156, 2020.

(出版サイトへのリンク): ● Publication site (DOI): 10.1111/ors.12461
(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-85075431466

(DOI: 10.1111/ors.12461, Elsevier: Scopus) Eri Sasabe, Ayumi Tomomura, Naoya Kitamura and Tetsuya Yamamoto :
Metal nanoparticles-induced activation of NLRP3 inflammasome in human oral keratinocytes is a possible mechanism of oral lichenoid lesions,
Toxicology In Vitro, Vol.62, 104663, 2020.

(要約): The NLRP3 inflammasome has been implicated in the pathogenesis of various inflammatory diseases and is activated by particulate stimulants. Oral epithelial keratinocytes are frequently exposed to metal nanoparticles. In this study, we examined the effects of gold, silver, and palladium nanoparticles, which are frequently used for dental metal alloys on cell proliferation, cytotoxicity, autophagy, lysosomal functions, and NLRP3 inflammasome activation using the immortalized human oral keratinocyte cell line RT-7. The metal nanoparticles were agglomerated in the membrane vesicles in RT-7 cells and suppressed cell proliferation and increased lactate dehydrogenase activity as well as the proportion of apoptotic cells. Silver and palladium nanoparticles induced autophagy and lysosomal dysfunctions and all metal nanoparticles tested triggered the secretion of IL-1β through caspase-1 activation. Furthermore, the epithelium obtained from patients with oral lichenoid lesions (OLLs) had robust NLRP3, ASC, caspase-1, and IL-1β-positive keratinocytes and cDNA microarray showed significant elevation in the mRNA levels of NLRP3. These results suggest that internalized metal nanoparticles in oral mucosal epithelial cells activate the NLRP3 inflammasome through the induction of lysosomal damage and autophagy dysfunction. This process may be involved in the pathogenesis of OLL and suggest its potential as an alternative target for OLL therapy.
(キーワード): Adolescent / Adult / Aged / Aged, 80 and over / Cell Line / Cell Proliferation / Cell Survival / Child / 女性 (female) / Gold / Humans / Inflammasomes / Keratinocytes / L-Lactate Dehydrogenase / Lichenoid Eruptions / 男性 (male) / Metal Nanoparticles / Middle Aged / Mouth / NLR Family, Pyrin Domain-Containing 3 Protein / Silver / Young Adult
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.tiv.2019.104663
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31669392; ● Summary page in Scopus @ Elsevier: 2-s2.0-85074284107

(DOI: 10.1016/j.tiv.2019.104663, PubMed: 31669392, Elsevier: Scopus) 北村直也, 大野清二, 山本哲也 :
舌下腺に生じた黄色肉芽腫性唾液腺炎の1例,
日本口腔内科学会雑誌, Vol.25, No.1, 20-24, 2019年.

(キーワード): 黄色肉芽腫性組織反応 / 黄色肉芽腫性唾液腺炎 / 舌下腺
(出版サイトへのリンク): ● Publication site (DOI): 10.6014/jjsom.25.20
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390846609789904000; ● Search Scopus @ Elsevier (DOI): 10.6014/jjsom.25.20

(DOI: 10.6014/jjsom.25.20, CiNii: 1390846609789904000) Naoya Kitamura, E Sasabe, H Kitaoka and T Yamamoto :
Unilateral necrosis of the tongue caused by embolisation of cholesterol crystals,
The British Journal of Oral & Maxillofacial Surgery, Vol.56, No.4, 340-342, 2018.

(要約): Cholesterol crystals embolise when an aortic atherosclerotic lesion ruptures and cholesterol crystals are scattered and obstruct small peripheral arterioles. Risk factors include both iatrogenic factors such as intravascular catheterisation, and spontaneous factors for atherosclerosis such as aging, hypertension, dyslipidaemia, and smoking. We describe the case of an 83-year-old Japanese man who developed unilateral, superficial necrosis of the tongue as a result of spontaneous embolisation of cholesterol crystals.
(キーワード): Aged, 80 and over / Embolism, Cholesterol / Humans / 男性 (male) / Necrosis / Tongue / Tongue Diseases
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.bjoms.2018.03.003
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29599050; ● Summary page in Scopus @ Elsevier: 2-s2.0-85044300534

(DOI: 10.1016/j.bjoms.2018.03.003, PubMed: 29599050, Elsevier: Scopus) 吉澤泰昌, 國藤潤, 仙頭慎哉, 冨田理生, 北村直也, 山本哲也 :
バーディーバーRh血液型患者に生じた舌癌の1例,
日本口腔外科学会雑誌, Vol.64, No.3, 184-188, 2018年.

(キーワード): バーディーバー血液 / 貯血式自己血輸血 / 不規則抗体 / 舌癌
(出版サイトへのリンク): ● Publication site (DOI): 10.5794/jjoms.64.184
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390001206531887744; ● Search Scopus @ Elsevier (DOI): 10.5794/jjoms.64.184

(DOI: 10.5794/jjoms.64.184, CiNii: 1390001206531887744) 北村直也, 溝渕隆宏, 大野清二, 吉澤泰昌, 山本哲也 :
上顎歯肉に発症したエイズ関連形質芽細胞リンパ腫の1例,
日本口腔腫瘍学会誌, Vol.29, No.4, 233-239, 2017年.

(キーワード): 形質芽細胞リンパ腫 / 歯肉腫瘍 / HIV / エイズ
(出版サイトへのリンク): ● Publication site (DOI): 10.5843/jsot.29.233
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390001204344018048; ● Search Scopus @ Elsevier (DOI): 10.5843/jsot.29.233

(DOI: 10.5843/jsot.29.233, CiNii: 1390001204344018048) Shinya Sento, Naoya Kitamura, Tetsuya Yamamoto, Koichi Nakashiro, Hiroyuki Hamakawa, Soichiro Ibaragi, Akira Sasaki, Natsumi Takamaru, Youji Miyamoto, Isamu Kodani, Kazuo Ryoke, Katsuaki Mishima and Yoshiya Ueyama :
Palonosetron Prevents Highly Emetogenic Chemotherapy-induced Nausea and Vomiting in Oral Cancer Patients,
Anticancer Research, Vol.37, No.12, 6977-6981, 2017.

(要約): To evaluate the efficacy of palonosetron in preventing acute and delayed nausea and vomiting in patients receiving highly emetogenic chemotherapy (HEC) in oral cancer patients. Oral cancer patients receiving HEC were enrolled; among the 40 patients, 87 courses of chemotherapy were administered. On day 1, 0.75 mg palonosetron was intravenously administrated just before chemotherapy. The primary endpoint was the proportion of patients with a complete response (CR) and the secondary endpoint was the proportion of patients with complete control (CC) during the acute and delayed phase. During the acute phase, 86 of 87 courses (98.9%) had CR and 84 of 87 courses (96.6%) had CC. During the delayed phase, 84 of 87 courses (96.6%) had CR and 70 of 87 courses (80.5%) had CC. Palonosetron is effective at preventing HEC-induced chemotherapy-induced nausea and vomiting (CINV) in oral cancer chemotherapeutic regimens in the acute and delayed phases.
(キーワード): Administration, Intravenous / Adult / Aged / Aged, 80 and over / Antineoplastic Agents / Cisplatin / Drug Therapy, Combination / 女性 (female) / Humans / Isoquinolines / 男性 (male) / Middle Aged / Mouth Neoplasms / Nausea / Palonosetron / Quinuclidines / Serotonin Antagonists / Treatment Outcome / Vomiting
(出版サイトへのリンク): ● Publication site (DOI): 10.21873/anticanres.12165
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29187483; ● Summary page in Scopus @ Elsevier: 2-s2.0-85038130164

(DOI: 10.21873/anticanres.12165, PubMed: 29187483, Elsevier: Scopus) Eri Sasabe, Ayumi Tomomura, Riki Tomita, Shinya Sento, Naoya Kitamura and Tetsuya Yamamoto :
Ephrin-B2 reverse signaling regulates progression and lymph node metastasis of oral squamous cell carcinoma,
PLoS ONE, Vol.12, No.11, e0188965, 2017.

(要約): Oral squamous cell carcinoma (OSCC) is a common malignant tumor of the head and neck and frequently metastasizes to cervical lymph nodes. Aggressive local invasion and metastasis of OSCC are significant factors for poor prognosis. In this study, we investigated whether ephrin-B2 expressed in OSCC contributed to tumor progression and lymph node metastasis. Clinical specimens from patients with OSCC had robust ephrin-B2-positive tumor cells and ephrin-B2 protein level was associated with clinical stage, lymph node metastasis, and poor survival outcomes. We also determined that ephrin-B2 protein level was increased in OSCC cell lines compared to normal human oral keratinocytes and that its levels were associated with the migratory and invasive potential of OSCC cell lines. Transfection of an EFNB2-specific small interfering RNA (siRNA) into SAS-L1 cells significantly reduced proliferation, attachment, migration, and invasion through phosphorylation of the epidermal growth factor receptor, FAK, ERK1/2, p38, AKT, and JNK1/2 pathways. Furthermore, knockdown of EFNB2 significantly suppressed adhesion and transmigration of SAS-L1 cells toward human lymphatic endothelial cells. In addition, the growth rate of tumor xenografts and cervical lymph node metastases of OSCC were suppressed by local injection of EFNB2 siRNA. These results suggest that ephrin-B2 overexpression and activation of the ephrin-B2 reverse signaling pathway in tumor microenvironment in OSCC facilitates progression and lymph node metastasis via enhancement of malignant potential and interaction with surrounding cells.
(キーワード): Animals / アポトーシス (apoptosis) / Carcinoma, Squamous Cell / Cell Line, Tumor / Cell Proliferation / Disease Progression / Ephrin-B2 / 女性 (female) / Gene Knockdown Techniques / Heterografts / Humans / Lymphatic Metastasis / 男性 (male) / Mice / Mice, SCID / Middle Aged / Mouth Neoplasms / Protein Kinases / Real-Time Polymerase Chain Reaction / Reverse Transcriptase Polymerase Chain Reaction / シグナル伝達 (signal transduction) / Tumor Microenvironment
(出版サイトへのリンク): ● Publication site (DOI): 10.1371/journal.pone.0188965
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29190834; ● Summary page in Scopus @ Elsevier: 2-s2.0-85035751819

(DOI: 10.1371/journal.pone.0188965, PubMed: 29190834, Elsevier: Scopus) 北村直也, 冨田理生, 仙頭慎哉, 濱田史人, 吉澤泰昌, 山本哲也 :
上唇に発生したPoroid hidradenomaの1例本邦における報告例に関する文献的考察,
日本口腔外科学会雑誌, Vol.62, No.2, 73-78, 2016年.

(キーワード): 孔細胞汗腺腫 / 汗孔腫 / 皮膚付属器腫瘍
(出版サイトへのリンク): ● Publication site (DOI): 10.5794/jjoms.62.73
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390282681508618496; ● Search Scopus @ Elsevier (DOI): 10.5794/jjoms.62.73

(DOI: 10.5794/jjoms.62.73, CiNii: 1390282681508618496) 村田智子, 仙頭慎哉, 笹部衣里, 北村直也, 弘井誠, 山本哲也 :
舌に発生したHybrid peripheral nerve sheath tumorの1例,
日本口腔外科学会雑誌, Vol.61, No.11, 591-594, 2015年.

(キーワード): ハイブリッド末梢神経鞘腫瘍 / 神経鞘腫 / 神経周膜腫 / 舌
(出版サイトへのリンク): ● Publication site (DOI): 10.5794/jjoms.61.591
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390282681508645376; ● Search Scopus @ Elsevier (DOI): 10.5794/jjoms.61.591

(DOI: 10.5794/jjoms.61.591, CiNii: 1390282681508645376) Tomohiro Yamada, Seiji Ohno, Naoya Kitamura, Eri Sasabe and Tetsuya Yamamoto :
SPARC is associated with carcinogenesis of oral squamous epithelium and consistent with cell competition,
Medical Molecular Morphology, Vol.48, No.3, 129-137, 2015.

(要約): The matricellular protein, secreted protein acidic and rich in cysteine (SPARC) is thought to be involved in cell competition. The objective of this study is to investigate the role of SPARC in cancerization of oral squamous epithelium. Clinical specimens from 57 pre- and early cancerous lesion, 66 invasive squamous cell carcinoma (SCC) and controls were immunostained with SPARC. Clinical features and SPARC expression were evaluated. Furthermore, effects of SPARC knockdown and overexpression were examined in oral cancer and keratinocyte cell lines. Leukoplakia, carcinoma in situ, and early invasive SCC had more SPARC-positive cells than normal mucous epithelium. However, there were no significant differences between leukoplakia, carcinoma in situ, and early SCC, and there were no correlations between SPARC immunoreactivity and prognosis of invasive oral SCCs. Cell proliferation was down-regulated by SPARC siRNA, and enhanced by SPARC transformed keratinocytes. But SPARC overexpression did not enhance cell migration activity. SPARC is induced by dysplastic cells in the early stage of cancerization, and may improve survival capability, but is not involved in malignancy. SPARC may act to escape from elimination by cell competition.
(キーワード): Adult / Aged / Aged, 80 and over / Carcinoma, Squamous Cell / Cell Proliferation / 女性 (female) / Gene Expression Regulation, Neoplastic / Humans / 男性 (male) / Middle Aged / Mouth Neoplasms / Osteonectin / Up-Regulation
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s00795-014-0089-5
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25311631; ● Summary page in Scopus @ Elsevier: 2-s2.0-84941423948

(DOI: 10.1007/s00795-014-0089-5, PubMed: 25311631, Elsevier: Scopus) Tomohiro Yamada, Naoya Kitamura, Eri Sasabe and Tetsuya Yamamoto :
Plasmablastic lymphoma of the upper gingiva in an HIV-negative elderly patient,
Oral and Maxillofacial Surgery Cases, Vol.1, No.2, 19-24, 2015.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.omsc.2015.05.002
(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-84938483824

(DOI: 10.1016/j.omsc.2015.05.002, Elsevier: Scopus) 大野清二, 笹光治郎, 高橋真由, 北村直也, 山田朋弘, 山本哲也 :
上顎洞内に生じた骨増生を伴う粘液囊胞の1例,
日本口腔外科学会雑誌, Vol.61, No.6, 325-329, 2015年.

(キーワード): 粘液囊胞 / 上顎洞 / 骨増生
(出版サイトへのリンク): ● Publication site (DOI): 10.5794/jjoms.61.325
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390001206530749312; ● Search Scopus @ Elsevier (DOI): 10.5794/jjoms.61.325

(DOI: 10.5794/jjoms.61.325, CiNii: 1390001206530749312) 中村美保, 岡崎雅史, 見元尚, 前田武英, 光畑知佐子, 西原えり子, 北村直也, 有瀬和美, 西崎紗矢香, 武内世生 :
エイズ中核拠点病院における訪問看護師に対する実地研修の有用性,
日本エイズ学会誌, Vol.17, No.2, 106-112, 2015年.

(キーワード): HIV感染症 / エイズ / 実地研修 / 訪問看護師 / 在宅医療
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1520853834682899456

(CiNii: 1520853834682899456) Naoya Kitamura, Riki Tomita, Mayo Yamamoto, Yasumasa Yoshizawa, Eri Sasabe, Tomohiro Yamada and Tetsuya Yamamoto :
Complete remission of Merkel cell carcinoma on the upper lip treated with radiation monotherapy and a literature review of Japanese cases,
World Journal of Surgical Oncology, Vol.13, 152, 2015.

(要約): Merkel cell carcinoma is a rare and aggressive neuroendocrine-derived skin cancer arising most commonly on the sun-exposed head and neck skin of elderly and immunocompromised patients. Although a combination of wide excision and adjuvant radiotherapy is the optimal therapeutic approach for Merkel cell carcinoma, radiation monotherapy has recently been recommended for unresectable tumors. We report here a case of Merkel cell carcinoma treated with radiation monotherapy and reviewed Merkel cell carcinoma cases treated with radiotherapy alone in Japan. A 75-year-old man was referred for treatment of a tumor on the upper lip with a swollen submental lymph node. The histopathological diagnosis from biopsied material was Merkel cell carcinoma (T3N1bM0, stage IIIB). The submental lymph node was extirpated and radiation monotherapy was applied according to the 2014 National Comprehensive Cancer Network Guidelines because the Eastern Cooperative Oncology Group Performance Status of the patient was grade 3 and the patient and his family did not desire surgery. The primary site and bilateral upper neck regions were irradiated with 45 Gy followed by 20 Gy irradiation for the primary site alone. Three months after radiotherapy, the tumor seemed to have completely remitted. Approximately 1 year after radiotherapy, no evidence of local recurrence or late metastasis has been noted. Radiation monotherapy should be considered as a curative treatment for Merkel cell carcinoma, particularly in situations where extensive surgery is not favored.
(キーワード): Aged / Carcinoma, Merkel Cell / Humans / 日本 (Japan) / Lip Neoplasms / 男性 (male) / Prognosis / Radiotherapy, Adjuvant / Remission Induction / Skin Neoplasms
(出版サイトへのリンク): ● Publication site (DOI): 10.1186/s12957-015-0564-z
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25886455; ● Summary page in Scopus @ Elsevier: 2-s2.0-84928807462

(DOI: 10.1186/s12957-015-0564-z, PubMed: 25886455, Elsevier: Scopus) Eri Sasabe, Ayumi Tomomura, Mayuko Hamada, Naoya Kitamura, Tomohiro Yamada and Tetsuya Yamamoto :
Nitric Oxide Attenuates Hypoxia-Induced 5-FU Resistance of Oral Squamous Cell Carcinoma Cells,
International Journal of Cancer and Clinical Research, Vol.2, No.1, 2015.

(出版サイトへのリンク): ● Publication site (DOI): 10.23937/2378-3419/2/2/1014
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.23937/2378-3419/2/2/1014

(DOI: 10.23937/2378-3419/2/2/1014) 山田朋弘, 北村直也, 笹部衣里, 山本哲也 :
下顎骨に発生した骨未分化高悪性度多形肉腫の1例,
日本口腔腫瘍学会誌, Vol.26, No.4, 193-198, 2014年.

(キーワード): 骨未分化高悪性度多形肉腫 / 下顎骨 / 悪性線維性組織球腫
(出版サイトへのリンク): ● Publication site (DOI): 10.5843/jsot.26.193
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390282679321944064; ● Search Scopus @ Elsevier (DOI): 10.5843/jsot.26.193

(DOI: 10.5843/jsot.26.193, CiNii: 1390282679321944064) Tomohiro Yamada, Mayu Takahashi, Manabu Matsumoto, Makoto Toi, Seiji Ohno, Naoya Kitamura, Eri Sasabe and Tetsuya Yamamoto :
Mucinous Cystadenoma in the Upper Lip: Report of Two Cases,
International Journal of Surgical Pathology, Vol.22, No.4, 364-368, 2014.

(要約): Mucinous cystadenoma of the salivary gland is a very rare disease, and only a few cases have been reported. We report here 2 cases of mucinous cystadenoma in the upper lip. The first case was a 57-year-old man and the second was a 42-year-old woman. The tumors were painless nodules with a smooth-surfaced mucosa, and surgical excisions were performed. Histologically, the tumors were surrounded by a fibrous capsule and were composed of multiple cysts lined with columnar epithelial cells. The tumor cells contain mucous substances that reacted with periodic acid-Schiff base and Alcian blue. Immunohistochemical staining revealed that the tumor cells expressed cytokeratin (AE1/3 and CK7), but their immunoreactivity with MIB-1 (Ki-67) was less than 3%. They had negative immunoreactivity for neuroectoderm markers, S-100 protein, and myoepithelial markers, p63, α-smooth muscle actin, and calponin, except for the accompanying myoepithelial-like cells. No recurrences were noted after surgery at 7 years and 1 year, respectively.
(キーワード): Adult / Biomarkers, Tumor / Cystadenoma, Mucinous / 女性 (female) / Humans / 免疫組織化学 (immunohistochemistry) / Lip Neoplasms / 男性 (male) / Middle Aged / Salivary Gland Neoplasms / Salivary Glands, Minor
(出版サイトへのリンク): ● Publication site (DOI): 10.1177/1066896913494796
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23855021; ● Summary page in Scopus @ Elsevier: 2-s2.0-84904095979

(DOI: 10.1177/1066896913494796, PubMed: 23855021, Elsevier: Scopus) Tomohiro Yamada, Azumi Hirata, Eri Sasabe, Tomohide Yoshimura, Seiji Ohno, Naoya Kitamura and Tetsuya Yamamoto :
TCDD disrupts posterior palatogenesis and causes cleft palate,
Journal of Cranio-Maxillo-Facial Surgery, Vol.42, No.1, 1-6, 2014.

(要約): Dioxins (e.g. 2,3,7,8-tetrachlorodibenzo-p-dioxin; TCDD) cause cleft palate at a high rate. A post-fusional split may contribute to the pathogenesis, and tissue fragility may be a concern. The objective of this study was to investigate the effects of TCDD on the palatal epithelium, bone and muscle, which contribute to tissue integrity. ICR mice (10-12 weeks old) were used. TCDD was administered on E12.5 at 40 mg/kg. Immunohistochemical staining for AhR, ER-α, laminin, collagen IV, osteopontin, Runx2, MyoD, and desmin were performed. Furthermore, western blot analysis for osteopontin, Runx2, MyoD, and desmin were performed to evaluate protein expression in the palatal tissue. Immunohistologically, there was little difference in the collagen IV and laminin localization in the palatal epithelium between control versus TCDD-treated mice. Runx2 and osteopontin immunoreactivity decreased in the TCDD-treated palatal bone, and MyoD and desmin decreased in the TCDD-treated palatal muscle. AhR and ER-α immunoreactivity were localized to the normal palatal bone, but ER-α was diminished in the TCDD-treated palate. On western blot analysis, Runx2, MyoD, and desmin were all downregulated in the TCDD-treated palate. TCDD may suppress palatal osteogenesis and myogenesis via AhR, and cause cleft palates via a post-fusional split mechanism, in addition to a failure of palatal fusion.
(キーワード): Animals / Basic Helix-Loop-Helix Transcription Factors / Blotting, Western / Cleft Palate / Collagen Type IV / Core Binding Factor Alpha 1 Subunit / Desmin / Down-Regulation / Epithelium / Estrogen Receptor alpha / 女性 (female) / Gestational Age / 免疫組織化学 (immunohistochemistry) / Laminin / Mice / Mice, Inbred ICR / Muscle Development / MyoD Protein / Osteogenesis / オステオポンティン (osteopontin) / Palatal Muscles / Palate / Palate, Hard / Polychlorinated Dibenzodioxins / Pregnancy / Receptors, Aryl Hydrocarbon / Teratogens
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jcms.2013.01.024
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23602632; ● Summary page in Scopus @ Elsevier: 2-s2.0-84890861036

(DOI: 10.1016/j.jcms.2013.01.024, PubMed: 23602632, Elsevier: Scopus) 長﨑敦洋, 仙頭慎哉, 笹部衣里, 北村直也, 山田朋弘, 山本哲也 :
特発性唾液腺型高アミラーゼ血症の1例,
日本口腔外科学会雑誌, Vol.60, No.1, 23-28, 2014年.

(キーワード): 高アミラーゼ血症 / 特発性 / マクロアミラーゼ / 唾液腺型
(出版サイトへのリンク): ● Publication site (DOI): 10.5794/jjoms.60.23
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390001206531343104; ● Search Scopus @ Elsevier (DOI): 10.5794/jjoms.60.23

(DOI: 10.5794/jjoms.60.23, CiNii: 1390001206531343104) 北村直也, 仙頭慎哉, 濱田史人, 大野清二, 山田朋弘, 山本哲也 :
習慣性顎関節脱臼に対する外科的処置とその問題点 Buckley-Terry法と関節結節削除術の比較,
日本口腔外科学会雑誌, Vol.60, No.1, 2-6, 2014年.

(キーワード): Buckley-Terry法 / 関節結節削除術 / 習慣性顎関節脱臼 / 再発 / 合併症
(出版サイトへのリンク): ● Publication site (DOI): 10.5794/jjoms.60.2
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390001206531344640; ● Search Scopus @ Elsevier (DOI): 10.5794/jjoms.60.2

(DOI: 10.5794/jjoms.60.2, CiNii: 1390001206531344640) 北村直也, 大野清二, 吉村友秀, 笹部衣里, 山田朋弘, 山本哲也 :
口腔内症状を初発とし随伴腫瘍が同定されなかった腫瘍随伴性天疱瘡の1例,
日本口腔外科学会雑誌, Vol.59, No.4, 254-258, 2013年.

(キーワード): 腫瘍随伴性天疱瘡 / 免疫学的検討 / 閉塞性細気管支炎様肺病変
(出版サイトへのリンク): ● Publication site (DOI): 10.5794/jjoms.59.254
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390282681508408704; ● Search Scopus @ Elsevier (DOI): 10.5794/jjoms.59.254

(DOI: 10.5794/jjoms.59.254, CiNii: 1390282681508408704) Tomohiro Yamada, Tomohide Yoshimura, Naoya Kitamura, Eri Sasabe, Seiji Ohno and Tetsuya Yamamoto :
Low-grade myofibroblastic sarcoma of the palate,
International Journal of Oral Science, Vol.4, No.3, 170-173, 2012.

(要約): Low-grade myofibroblastic sarcoma (LGMS) is a rare, malignant tumor with myofibroblastic differentiation. Despite it being classified as a distinct entity by the World Health Organization, a few cases were reported in the oral and maxillofacial region. Here, a LGMS developed on the palate of a 73-year-old man who presented with a 1-cm tumor on the posterior border of the palate. Based on the histological and immunohistochemical features, a diagnosis of LGMS was established. The tumor was resected, and no recurrence was observed over 2 years. Although the tongue is the most preferred site for LGMS, it may occur in any region of the oral cavity.
(キーワード): Aged / Humans / 男性 (male) / Myofibroblasts / Osteosarcoma / Palatal Neoplasms / Palate, Hard
(出版サイトへのリンク): ● Publication site (DOI): 10.1038/ijos.2012.49
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22935748; ● Summary page in Scopus @ Elsevier: 2-s2.0-84866947787

(DOI: 10.1038/ijos.2012.49, PubMed: 22935748, Elsevier: Scopus) Tomohiro Yamada, Moritoshi Uchida, Kang Kwang-Lee, Naoya Kitamura, Tomohide Yoshimura, Eri Sasabe and Tetsuya Yamamoto :
Correlation of metabolism/hypoxia markers and fluorodeoxyglucose uptake in oral squamous cell carcinomas,
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Vol.113, No.4, 464-471, 2012.

(要約): The objective of this study was to analyze the relationship between the uptake of (18)F-2-fluoro-2-deoxy-d-glucose (FDG) by positron emission tomography-computerized tomography (PET-CT) and glucose metabolism/hypoxia markers in oral squamous cell carcinoma (OSCC). Thirty-six patients with OSCC (tongue [n = 23], buccal mucosa [n = 7], and floor of the mouth [n = 6]) were assessed and underwent incisional biopsy and subsequently received FDG-PET-CT. Expressions of hypoxia-inducible factor 1α (HIF-1α), glucose transporter protein 1 (GLUT-1), hexokinase-II (HK-II), and glucose-6-phosphatase (G6Pase) were immunohistochemically quantified, and FDG uptake was evaluated by the maximum standardized uptake values (SUV(max)) at the primary tumor site. FDG uptake was found to be significantly correlated with the T classification of OSCC but not with other clinicopathologic characteristics, such as the N classification, clinical type, and histologic grade of malignancy. In the early-stage (T1 and T2) tumor, FDG uptake was significantly associated with the expression levels of GLUT-1, HK II, and HIF-1α, and the expression levels of GLUT-1 and HK-II significantly correlated with HIF-1α expression levels. However, there were no correlations between the expression levels of these molecules and SUV(max) in the late-stage (T3 and T4) tumor. FDG uptake was significantly associated with the expression levels of glucose metabolism-related molecules, such as GLUT-1, HK II, and HIF-1α, especially in early-stage tumors.
(キーワード): Aged / Aged, 80 and over / Carcinoma, Squamous Cell / 女性 (female) / Fluorodeoxyglucose F18 / グルコース (glucose) / Glucose Transporter Type 1 / Glucose-6-Phosphatase / Hexokinase / Humans / Hypoxia / Hypoxia-Inducible Factor 1, alpha Subunit / 男性 (male) / Middle Aged / Mouth Floor / Mouth Mucosa / Mouth Neoplasms / Neoplasm Grading / Neoplasm Staging / Positron-Emission Tomography / Statistics, Nonparametric / Tongue
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.tripleo.2011.04.006
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22676927; ● Search Scopus @ Elsevier (PMID): 22676927; ● Search Scopus @ Elsevier (DOI): 10.1016/j.tripleo.2011.04.006

(DOI: 10.1016/j.tripleo.2011.04.006, PubMed: 22676927) Tomohide YOSHIMURA, Seiji OHNO, Naoya Kitamura, Eri SASABE, Tomohiro YAMADA and Tetsuya YAMAMOTO :
A case of intravascular papillary endothelial hyperplasia in the alveolar mucosa,
Journal of The Japanese Stomatological Society, Vol.61, No.2, 233-236, 2012.

(キーワード): 血管内乳頭状内皮過形成 / 歯槽粘膜 / 歯根端切除術
(出版サイトへのリンク): ● Publication site (DOI): 10.11277/stomatology.61.233
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390001206436440064; ● Search Scopus @ Elsevier (DOI): 10.11277/stomatology.61.233

(DOI: 10.11277/stomatology.61.233, CiNii: 1390001206436440064) H Satake, T Yamada, Naoya Kitamura, T Yoshimura, E Sasabe and T Yamamoto :
Post-surgical unilateral temporomandibular joint dislocation treated by open reduction followed by orthodontic treatment,
International Journal of Oral and Maxillofacial Surgery, Vol.40, No.3, 335-338, 2011.

(要約): A case of prolonged unilateral temporomandibular joint (TMJ) dislocation, which was treated by open surgical reduction and post-surgical orthodontic therapy, is presented. A 58-year-old woman presented complaining of facial asymmetry and malocclusion. She had received surgery for a malignant tumour in the right retromolar region 7 years previously. It was considered that contraction of the pterygoid muscle by surgical injury caused anterior meniscal displacement and TMJ dislocation. Since manual manipulation failed, direct open reduction was performed after separation of the lateral pterygoid muscle from the condylar head and removal of the intra-articular scar tissues. Although the condylar head was returned to the glenoid fossa, optimal occlusion was not obtained because of compensatory tooth movement and inclination. Satisfactory occlusion and symmetric facial appearance were brought about by post-surgical orthodontic therapy.
(キーワード): Contracture / Facial Asymmetry / 女性 (female) / Follow-Up Studies / Humans / Intraoperative Complications / Joint Dislocations / Malocclusion / Mandibular Condyle / Mandibular Neoplasms / Middle Aged / 開咬 (open bite) / Orthodontics, Corrective / Pterygoid Muscles / Temporomandibular Joint Disorders
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.ijom.2010.09.017
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20970308; ● Summary page in Scopus @ Elsevier: 2-s2.0-79952310284

(DOI: 10.1016/j.ijom.2010.09.017, PubMed: 20970308, Elsevier: Scopus) 中谷倫子, 成川玄, 中村裕一郎, 北村直也, 山田朋弘, 山本哲也 :
コルチコステロイドの局所注射が奏効した下顎骨ランゲルハンス細胞組織球症の1例,
日本口腔外科学会雑誌, Vol.57, No.3, 128-132, 2011年.

(キーワード): ランゲルハンス細胞組織球症 / 副腎皮質ホルモン / 局所注射 / 下顎
(出版サイトへのリンク): ● Publication site (DOI): 10.5794/jjoms.57.128
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390282681507720832; ● Search Scopus @ Elsevier (DOI): 10.5794/jjoms.57.128

(DOI: 10.5794/jjoms.57.128, CiNii: 1390282681507720832) Satoshi Ito, Toshiko Mandai, Kosei Ishida, Naoya Kitamura, Hiroyo Deguchi, Tsuyoshi Hata, Isao Irei and Masaru Hosoda :
Unicystic ameloblastoma of the maxilla: A case report,
Kawasaki Medical Journal, Vol.35, No.1, 95-98, 2009. 石田光生, 北村直也, 伊藤聡, 出口博代, 畑毅, 細田超 :
遊離腓骨皮弁移植により再建された下顎への歯科用インプラント義歯症例,
川崎医学会誌, Vol.34, No.3, 203-209, 2008年.

(要約): 症例報告
(キーワード): Dental implant / Mandible reconstruction / Vascularised fibular free-flap
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1050564287583231488

(CiNii: 1050564287583231488) 石田光生, 伊藤聡, 北村直也, 出口博代, 畑毅, 細田超 :
左側耳下腺に同時性にみられた多形性腺腫とWarthin腫瘍の1例,
日本口腔外科学会雑誌, Vol.53, No.8, 509-513, 2007年.

(キーワード): 同一耳下腺 / 多形性腺腫 / Warthin腫瘍
(出版サイトへのリンク): ● Publication site (DOI): 10.5794/jjoms.53.509
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390001206530903680; ● Search Scopus @ Elsevier (DOI): 10.5794/jjoms.53.509

(DOI: 10.5794/jjoms.53.509, CiNii: 1390001206530903680) 北村直也, 石田光生, 出口博代, 畑毅, 岡本哲治, 細田超 :
大腸癌が上顎および頸部リンパ節に転移した1例,
日本口腔外科学会雑誌, Vol.53, No.8, 504-508, 2007年.

(キーワード): 転移性口腔腫瘍 / 生活の質 (quality of life) / 横行結腸腺癌 / 遠隔転移
(出版サイトへのリンク): ● Publication site (DOI): 10.5794/jjoms.53.504
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390282681507613952; ● Search Scopus @ Elsevier (DOI): 10.5794/jjoms.53.504

(DOI: 10.5794/jjoms.53.504, CiNii: 1390282681507613952) 北村直也, 石田光生, 伊藤聡, 出口博代, 畑毅, 細田超 :
遊離皮弁による舌再建後に発症した急性肺血栓塞栓症の1例,
日本口腔外科学会雑誌, Vol.52, No.10, 565-568, 2006年.

(キーワード): 肺血栓塞栓症 / 遊離皮弁再建 / 抗血栓療法 / 抗凝固療法 / 血栓溶解療法
(出版サイトへのリンク): ● Publication site (DOI): 10.5794/jjoms.52.565
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390001206532517248; ● Search Scopus @ Elsevier (DOI): 10.5794/jjoms.52.565

(DOI: 10.5794/jjoms.52.565, CiNii: 1390001206532517248) Yan Zhang, Hua Wang, Akihide Kamegai, Tsuyoshi Hata, Naoya Kitamura, Masaru Hosoda, Ryouji Tani, Yasutaka Hayashido, Shigeaki Toratani and Tetsuji Okamoto :
Developmental Signaling Disorders in Craniofacial Anomalies and Cancers,
Oral Science International, Vol.3, No.2, 56-63, 2006.

(出版サイトへのリンク): ● Publication site (DOI): 10.11277/osi.3.56
(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-85024724651

(DOI: 10.11277/osi.3.56, Elsevier: Scopus) Chika Koike, Taketoshi Mizutani, Taiji Ito, Yasuhito Shimizu, Nobutake Yamamichi, Takashi Kameda, Eiji Michimukai, Naoya Kitamura, Tetsuji Okamoto and Hideo Iba :
Introduction of wild-type patched gene suppresses the oncogenic potential of human squamous cell carcinoma cell lines including A431,
Oncogene, Vol.21, No.17, 2670-2678, 2002.

(要約): Defects in a developmental signaling pathway involving the mammalian homologue of the Drosophila segment polarity gene, patched are associated with human tumors such as basal cell carcinoma, medulloblastoma and squamous cell carcinoma. Loss of heterozygosity (LOH) in some of these tumor cells suggests that patched functions as a tumor suppressor gene. To evaluate the biological significance of patched mutations in human sporadic tumor cells, we constructed a VSV-G pseudotyped retrovirus vector carrying the wild-type patched gene and transduced it into two human squamous cell carcinoma (SCC) cell lines, A431 and KA, that express only mutant patched mRNA. When SSC cells were transduced with Ptc virus, colony forming activity in soft agar was drastically reduced and these cells recovered anchorage independent growth when Sonic hedgehog (Shh), the ligand of Patched (Ptc), was added into the soft agar culture. Expression of exogenous patched, however, had no effect on anchorage independent growth of Ras-transformed NIH3T3 cells or SCC cell line, NA, which expresses wild-type patched mRNA. Cyclopamine, a specific inhibitor of the Shh/Ptc/Smo signaling pathway, efficiently suppressed anchorage independent growth of A431 and KA cells. These results indicate that loss of patched function plays a major role in the acquisition of oncogenic potential in these SCCs and further that Ptc virus would be an effective reagent for suppressing tumorigenicity of such SCCs.
(キーワード): Animals / Blotting, Western / Carcinoma, Squamous Cell / DNA Primers / DNA, Neoplasm / Genetic Vectors / Hedgehog Proteins / Humans / Intracellular Signaling Peptides and Proteins / Membrane Proteins / Mice / Oncogene Proteins / Patched Receptors / Patched-1 Receptor / RNA, Messenger / Receptors, Cell Surface / Retroviridae / Reverse Transcriptase Polymerase Chain Reaction / Trans-Activators / Transcription Factors / Transfection / Tumor Cells, Cultured / Veratrum Alkaloids / Zinc Finger Protein GLI1
(出版サイトへのリンク): ● Publication site (DOI): 10.1038/sj.onc.1205370
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11965540; ● Summary page in Scopus @ Elsevier: 2-s2.0-18344379127

(DOI: 10.1038/sj.onc.1205370, PubMed: 11965540, Elsevier: Scopus) Eiji Michimukai, Naoya Kitamura, Yan Zhang, Hua Wang, Yoshiko Hiraishi, Ken-Saku Sumi, Yasutaka Hayashido, Shigeaki Toratani and Tetsuji Okamoto :
Mutations in the human homologue of the drosophila segment polarity gene patched in oral squamous cell carcinoma cell lines,
In Vitro Cellular & Developmental Biology. Animal, Vol.37, No.7, 459-464, 2001.

(要約): In the present study, we have analyzed tumor deoxyribonucleic acid from oral squamous cell carcinoma (OSCC) cells for patched mutations using an exon-by-exon single strand conformation polymorphism assay and direct sequencing. We found two missense mutations which affected the conserved residue in the transmembrane domains of the gene product and in the intracellular loop at the C-terminal residue implicated in regulating the smoothened molecule. In addition, we demonstrated that the N-terminal fragment of sonic hedgehog (Shh-N) stimulates the growth of normal epithelial cells, the OSCC cell line, NA, and the salivary gland adenocarcinoma cell lines, HSG and HSY, which have no detectable mutation in patched. On the other hand, Shh has no effect on human SCC cells (UE, KA, KO, NI, A431 cells) that have mutations in patched. These results strongly suggest that an Shh-patched signaling is involved in the cell growth of oral epithelial cells and in the tumorigenesis of OSCCs.
(キーワード): Carcinoma, Squamous Cell / Cell Division / Culture Media, Serum-Free / DNA Mutational Analysis / DNA, Neoplasm / Epithelial Cells / Hedgehog Proteins / Humans / Membrane Proteins / Mouth Neoplasms / Mutation / Mutation, Missense / Patched Receptors / Peptide Fragments / Polymorphism, Single-Stranded Conformational / RNA, Messenger / Receptors, Cell Surface / Sequence Analysis, DNA / シグナル伝達 (signal transduction) / Trans-Activators / Tumor Cells, Cultured
(出版サイトへのリンク): ● Publication site (DOI): 10.1290/1071-2690(2001)037<0459:mithho>2.0.co;2
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11573822; ● Summary page in Scopus @ Elsevier: 2-s2.0-0034837024

(DOI: 10.1290/1071-2690(2001)037<0459:mithho>2.0.co;2, PubMed: 11573822, Elsevier: Scopus)

MISC

山田朋弘, 笹部衣里, 吉村友秀, 北村直也, 大野清二, 李康広, 山本哲也 :
ピロカルピン塩酸塩の口腔乾燥症に対する臨床的効果の検討,
診療と新薬, Vol.49, No.2, 236-242, 2012年. 畑毅, 石田光生, 伊藤聡, 北村直也, 出口博代, 細田超 :
外耳道骨折を伴った関節突起骨折の1例,
川崎医学会誌, Vol.33, No.1, 49-55, 2007年.

(要約): 症例報告
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1050001337629792512

(CiNii: 1050001337629792512) 畑毅, 釋舎竜司, 永井清久, 伊藤聡, 石田光生, 北村直也, 出口博代, 細田超, 吉田耕治 :
保存療法を施行した顎関節円板前方転移症例の臨床経過ならびにMRI所見の検討,
川崎医学会誌, Vol.31, No.4, 227-233, 2005年.

総説・解説

研究者総覧に該当データはありませんでした。

講演・発表

Naoya Kitamura, Yumiko Hashida, Tomonori Higuchi, Eri Sasabe, Masanori Daibata and Tetsuya Yamamoto :
Detection of Merkel cell polyomavirus in multiple primary oral squamous cell carcinomas,
Taiwanese Association of Oral & Maxillofacial Surgeons, The 35th Annual Conference on Oral and Maxillofacial Surgery, Taipei, Mar. 2023. 高野栄之, 鳥井浩平, 桃田幸弘, 北村直也, 寺田賢治 :
大規模災害時の歯科的個人識別において画像解析や遠隔作業は許容されうるのか?,
日本法歯科医学会第18回学術大会, C-4, 2024年5月.

(キーワード): 歯科医療 (dental care) / 画像処理 (image processing)

北村直也 :
習慣性顎関節脱臼への対応-関節隆起切除術の術式と周術期管理を中心に-,
第59回・第60回(公社)日本口腔外科学会教育研修会口腔四学会合同研修会, 2024年2月. 北村直也, 山本哲也 :
当科における唾液腺腫瘍の臨床的検討,
第42回日本口腔腫瘍学会総会・学術大会, 2024年1月. 北村直也, 笹部衣里, 山本哲也 :
口腔扁平上皮癌におけるメルケル細胞ポリオーマウイルスの関わり- 口腔内多発癌ではウイルス検出率が高く，ウイルス量も多い –,
第59回日本口腔組織培養学会, 2023年11月. 北村直也, 笹部衣里, 山本哲也 :
口腔内多発癌におけるメルケル細胞ポリオーマウイルスの関わり,
第68回(公社)日本口腔外科学会総会・学術大会, 2023年11月. 北村直也, 山本哲也 :
有病高齢者の習慣性顎関節脱臼に対する関節隆起切除術ー適応，術式，周術期管理ー,
第68回(公社)日本口腔外科学会総会・学術大会, 2023年11月. 北村直也, 山本哲也 :
有病高齢者の習慣性顎関節脱臼に対する関節隆起切除術の適応と周術期管理,
第25回顎顔面手術手技研究会顎関節脱臼への対応, 2023年5月. 北村直也, 山本哲也 :
口腔扁平上皮癌における口腔ポリオーマウイルスの関わり,
第67回(公社)日本口腔外科学会総会・学術大会シンポジウム1, 2022年11月. 北村直也 :
有病高齢者の習慣性顎関節脱臼に対する外科療法のポイント,
第66回(公社)日本口腔外科学会総会・学術大会ビデオレクチャー6, 2021年11月. 北村直也 :
高齢者の習慣性顎関節脱臼に対する外科的療法のポイント,
第65回(公社)日本口腔外科学会総会・学術集会ビデオレクチャー5, 2020年11月. 北村直也, 山本哲也 :
高齢者の習慣性顎関節脱臼に対する外科的処置とその問題点,
第64回(公社)日本口腔外科学会総会・学術集会シンポジウム2「顎関節脱臼に対する外科療法」, 2019年10月. 北村直也, 山本哲也 :
口底正中に生じた暗赤色腫瘤,
第29回日本口腔内科学会 Clinicopathological conference「この病変，診断つきますか」, 2019年9月. 中瀬洋司, 濱田充子, 中峠洋隆, 大林史誠, 山崎佐知子, 畑毅, 北村直也, 山本哲也, 虎谷茂昭, 岡本哲治 :
基底細胞母斑症候群(NBCCS)の変異解析及びインテグレーションフリー・フィーダーフリー・無血清培養系でのNBCCS特異的iPSCの樹立,
日本口腔科学会雑誌, 2019年7月.

研究会・報告書: 笹部衣里, 仙頭慎哉, 北村直也, 山本哲也 :
口腔扁平上皮癌細胞へのエクソソームの取り込みにはEGFRシグナル伝達が関与する,
口腔組織培養学会誌, Vol.31, No.1, 3-4, 2022年3月. 笹部衣里, 仙頭慎哉, 北村直也, 山本哲也 :
口腔扁平上皮癌の抗癌剤耐性獲得における細胞老化関連分泌現象の関わり,
口腔組織培養学会誌, Vol.29, No.1, 13-14, 2020年3月. 中瀬洋司, 濱田充子, 中峠洋隆, 大林史誠, 山崎佐知子, 畑毅, 北村直也, 山本哲也, 虎谷茂昭, 岡本哲治 :
疾患特異的induced pluripotent stem cell(DS-iPSC)の樹立と疾患研究,
口腔組織培養学会誌, Vol.28, No.1, 23-24, 2019年3月. 仙頭慎哉, 笹部衣里, 北村直也, 山本哲也 :
エクソソーム取り込みを標的とする口腔癌治療薬の探索,
口腔組織培養学会誌, Vol.27, No.1, 27-28, 2018年3月. 笹部衣里, 仙頭慎哉, 北村直也, 山本哲也 :
口腔粘膜上皮細胞のインフラマソームに及ぼす金属ナノ粒子の影響,
口腔組織培養学会誌, Vol.26, No.1, 39-40, 2017年3月. 石黒光葉, 北村直也, 吉澤泰昌, 笹部衣里, 山田朋弘, 山本哲也 :
口腔内に発生した形質芽細胞リンパ腫の2例 HIV陽性例と陰性例,
日本口腔科学会雑誌, Vol.65, No.1, 58, 2016年3月. 仙頭慎哉, 笹部衣里, 北村直也, 山本哲也 :
口腔扁平上皮癌細胞分泌エクソソームを標的とした治療に関する基礎的研究,
口腔組織培養学会誌, Vol.25, No.1, 15-16, 2016年1月. 笹部衣里, 仙頭慎哉, 大野清二, 北村直也, 山本哲也 :
NK細胞の細胞傷害活性に及ぼすCXCL10の影響,
口腔組織培養学会誌, Vol.24, No.1, 33-34, 2015年2月. 仙頭慎哉, 笹部衣里, 大野清二, 北村直也, 山本哲也 :
口腔扁平上皮癌細胞分泌エクソソームによる腫瘍悪性化促進機序の解明,
口腔組織培養学会誌, Vol.23, No.1, 120-121, 2014年11月. 山田朋弘, 中谷倫子, 大野清二, 森下慶子, 北村直也, 笹部衣里, 山本哲也 :
片側性に生じた口腔扁平苔癬の臨床・病理組織学的検討,
日本口腔診断学会雑誌, Vol.27, No.1, 108-109, 2014年2月. 仙頭慎哉, 笹部衣里, 北村直也, 山田朋弘, 山本哲也 :
口腔扁平上皮癌細胞が分泌するエクソソームに含まれる核酸および蛋白質の働き,
日本口腔科学会雑誌, Vol.63, No.1, 121-122, 2014年1月. 山田朋弘, 中谷倫子, 大野清二, 森下慶子, 北村直也, 笹部衣里, 山本哲也 :
片側性に生じた口腔扁平苔癬の臨床・病理組織学的検討,
日本口腔内科学会雑誌, Vol.19, No.2, 107-108, 2013年12月. 仙頭慎哉, 吉村友秀, 笹部衣里, 北村直也, 山田朋弘, 山本哲也 :
扁平上皮癌細胞由来エクソソームが放射線感受性に及ぼす影響,
日本口腔科学会雑誌, Vol.62, No.2, 202, 2013年3月. 大野清二, 笹部衣里, 北村直也, 山本哲也 :
口腔扁平上皮癌の発癌におけるSPARCを介した細胞競合の関わり,
口腔組織培養学会誌, Vol.22, No.1, 45-46, 2013年2月. 北村直也, 長崎敦洋, 仙頭慎哉, 大野清二, 吉村友秀, 笹部衣里, 山田朋弘, 山本哲也 :
口腔癌患者の化学放射線療法による口内炎に対するオピオイドの併用効果,
日本口腔科学会雑誌, Vol.62, No.1, 86, 2013年1月. 山田朋弘, 大野清二, 笹部衣里, 長崎敦洋, 北村直也, 山本哲也 :
口腔扁平上皮癌の発癌ならびに進展におけるSPARCの関わり,
日本口腔科学会雑誌, Vol.62, No.1, 41-42, 2013年1月. 笹部衣里, 吉村友秀, 大野清二, 北村直也, 山本哲也 :
口腔扁平上皮癌に対する抗癌剤と一酸化窒素との併用療法に関する基礎的検討,
口腔組織培養学会誌, Vol.21, No.1, 19-20, 2012年2月. 山田朋弘, 中谷倫子, 領木崇人, 北村直也, 山本哲也 :
塩酸ピロカルピンの口腔乾燥症に対する臨床的効果の検討,
日本口腔科学会雑誌, Vol.61, No.1, 156-157, 2012年1月. 北村直也, 吉村友秀, 大野清二, 山田朋弘, 山本哲也 :
当科におけるインプラント治療に関連した紹介患者の臨床的検討,
Japanese Journal of Maxillo Facial Implants, Vol.10, No.3, 209, 2011年11月. 吉村友秀, 成川玄, 北村直也, 山田朋弘, 山本哲也 :
頸部郭清術中に脳梗塞を発症した頸動脈狭窄症を有する舌癌患者の1例,
日本口腔外科学会雑誌, Vol.57, No.Suppl., 259, 2011年9月. 山田朋弘, 森仁志, 森下慶子, 成川玄, 中谷倫子, 仙頭慎哉, 北村直也, 山本哲也 :
当科における口腔扁平上皮癌T4症例の臨床病理組織学的検討,
日本口腔外科学会雑誌, Vol.57, No.Suppl., 198, 2011年9月. 北村直也, 吉村友秀, 李康広, 笹部衣里, 山田朋弘, 山本哲也 :
口腔癌における近赤外線蛍光カラーカメラシステムを用いたセンチネルリンパ節の同定,
日本口腔外科学会雑誌, Vol.57, No.Suppl., 131, 2011年9月. 北村直也, 大野清二, 森下慶子, 成川玄, 中村裕一郎, 山田朋弘, 山本哲也 :
当科における放射線性顎骨骨髄炎症例の臨床的検討,
日本口腔科学会雑誌, Vol.60, No.3, 295, 2011年7月. 吉村友秀, 笹部衣里, 北村直也, 山本哲也 :
口腔扁平上皮癌におけるマイクロRNAの発現と増殖・浸潤における役割についての検討,
口腔組織培養学会誌, Vol.20, No.1, 43-44, 2011年2月. 笹部衣里, 大野清二, 北村直也, 山田朋弘, 山本哲也 :
口腔扁平上皮癌に対する抗癌剤と一酸化窒素併用療法に関する基礎的検討,
日本口腔科学会雑誌, Vol.60, No.1, 72-73, 2011年1月. 北村直也, 領木崇人, 大野清二, 成川玄, 山田朋弘, 山本哲也 :
当科における顎骨骨髄炎症例の臨床的検討,
日本口腔外科学会雑誌, Vol.56, No.Suppl., 101, 2010年9月. 山田朋弘, 吉村友秀, 北村直也, 笹部衣里, 山本哲也 :
口腔扁平上皮癌におけるFDG PET-CTのSUVmax値と低酸素関連分子発現との関連,
日本口腔外科学会雑誌, Vol.56, No.Suppl., 95, 2010年9月. 河野倫子, 成川玄, 中村裕一郎, 北村直也, 佐竹秀太, 山田朋弘, 山本哲也 :
コルチコステロイドの局所注射が奏効した下顎骨ランゲルハンス細胞組織球症の1例,
日本口腔科学会雑誌, Vol.59, No.2, 92, 2010年3月. 大野清二, 吉村友秀, 北村直也, 笹部衣里, 山本哲也 :
不死化正常ヒト角化細胞のタイトジャンクションに及ぼす炎症性サイトカインの影響,
口腔組織培養学会誌, Vol.19, No.1, 45-46, 2010年2月. 北村直也, 大野清二, 森下慶子, 河野倫子, 成川玄, 吉村友秀, 山田朋弘, 山本哲也 :
口腔癌に対するDocetaxel併用化学・放射線療法における有害事象の検討,
日本口腔外科学会雑誌, Vol.55, No.Suppl., 117, 2009年9月. 張雁, 北村直也, 虎谷茂昭, 岡本哲治 :
口腔粘膜上皮細胞および口腔扁平上皮癌細胞株におけるPatched-1 Splicing Variantの同定とその機能解析,
組織培養研究, Vol.25, No.1, 66, 2006年3月. 北村直也, 張雁, 汪華, 林堂安貴, 虎谷茂昭, 細田超, 岡本哲治 :
野性型patched遺伝子導入によるヒト扁平上皮癌細胞の増殖制御,
口腔組織培養学会誌, Vol.12, No.1, 41-42, 2003年3月. 汪華, 張雁, 岡本康正, 神田拓, 北村直也, 福井康人, 林堂安貴, 虎谷茂昭, 岡本哲治 :
ヒト唾液腺におけるアンジオポエチンとその受容体Tie-2の機能解析,
口腔組織培養学会誌, Vol.11, No.1, 47-48, 2002年3月.

特許: 北村直也, 松崎茂展, 山本哲也, 大畑雅典 : 黄色ブドウ球菌および/または緑膿菌を原因とする感染症の治療剤, 特願2019-041510 (2019年3月), 特許第7385233号 (2023年11月).
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研究者総覧で最新データを確認する

2024年11月22日更新

専門分野・研究分野: 歯学 (Dentistry)
ライフサイエンス
外科系歯学 (Oral and Maxillofacial Surgery)
所属学会・所属協会: 日本口腔感染症学会
日本口腔内科学会
日本口腔腫瘍学会
日本顎顔面インプラント学会
特定非営利活動法人日本口腔科学会
アジア口腔顎顔面外科学会
日本口腔組織培養学会
社団法人日本口腔外科学会改訂合同委員会策定グループ委員 [2021年5月〜2024年2月], 代議員 [2014年7月〜2022年6月])
社団法人日本口腔外科学会
総合歯科学会
日本歯科医学教育学会
委員歴・役員歴: 特定非営利活動法人日本口腔科学会 ( [2006年9月〜2039年3月])
アジア口腔顎顔面外科学会 ( [2004年7月〜2039年3月])
日本口腔組織培養学会 ( [2002年4月〜2039年3月])
社団法人日本口腔外科学会 (口腔がん診療ガイドライン(2023年版)改訂合同委員会策定グループ委員 [2021年5月〜2024年2月], 代議員 [2014年7月〜2022年6月])
社団法人日本口腔外科学会 ( [1999年10月〜2039年3月])
受賞: 2020年4月, 学会賞優秀ポスター賞 (NPO法人日本口腔科学会)
2020年10月, 奨励賞 (広島大学顎・口腔外科(第一口腔外科)同門会)
活動: 国公立大学附属病院感染対策協議会 (歯科医療部門ガイドライン作業部会委員 [2019年11月〜])

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Jグローバル最終確認日: 2024/11/16 01:08
氏名（漢字）: 北村直也
氏名（フリガナ）: キタムラナオヤ
氏名（英字）: Kitamura Naoya
所属機関: 徳島大学大学院医歯薬学研究部教授

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researchmap最終確認日: 2024/11/17 01:09
氏名（漢字）: 北村直也
氏名（フリガナ）: キタムラナオヤ
氏名（英字）: Kitamura Naoya
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研究者番号: 70351921

所属（現在）: 2024/4/1 : 徳島大学, 大学院医歯薬学研究部(歯学域), 教授

所属（過去の研究課題 情報に基づく）*注記: 2024/4/1 : 徳島大学, 大学院医歯薬学研究部(歯学域), 教授
2015/4/1 – 2023/4/1 : 高知大学, 教育研究部医療学系臨床医学部門, 講師
2010/4/1 – 2014/4/1 : 高知大学, 教育研究部医療学系, 助教
2013/4/1 : 高知大学, 医歯学系, 助教
2009/4/1 – 2011/4/1 : 高知大学, 教育研究部・医療学系, 助教
2004/4/1 – 2005/4/1 : 川崎医科大学, 医学部, 助手

審査区分/研究分野

研究代表者

生物系 / 医歯薬学 / 歯学 / 外科系歯学
生物系 / 医歯薬学 / 歯学 / 病態科学系歯学・歯科放射線学
小区分57060:外科系歯学関連

研究代表者以外

生物系 / 医歯薬学 / 歯学 / 外科系歯学
生物系 / 医歯薬学 / 歯学 / 病態科学系歯学・歯科放射線学
小区分54030:感染症内科学関連
小区分57060:外科系歯学関連

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研究代表者

口腔癌 / センチネルリンパ節 / 赤外観察カメラシステム / RI法 / MFG-E8 / 口腔扁平上皮癌 / LAK細胞 / インフラマソーム / 口腔扁平苔癬 / バクテリオファージ / 薬剤耐性 / 黄色ブドウ球菌 / ファージ療法 / ゲノム解析 / メチシリン耐性黄色ブドウ球菌 / 抗菌薬耐性 / 誤嚥性肺炎 / マイクロバイオーム / 重複癌 / ポリオーマウイルス / 腫瘍ウイルス / 共感染 / Field cancerization / 他臓器重複癌

研究代表者以外

口腔カンジダ症 / 病原因子 / 唾液 / 抗菌ペプチド / カンジダ / 病原性 / 口腔カンジダ菌 / 抗真菌剤 / Phenotype / Genotype / MIC / 低酸素 / 口腔扁平上皮癌 / 抗腫瘍免疫 / HIF-1α / NK細胞 / LAK細胞 / 細胞競合 / 扁平上皮癌 / SPARC / 腫瘍関連マクロファージ / 抗がん剤 / 抗癌剤 / エクソソーム / マイクロRNA / miRNA / microRNA / センチネルリンパ節 / 生検 / 頸部郭清術 / 頸部リンパ節 / 選択的頸部郭清術 / 頸部リンパ節転移 / sentinel lymph node / biopsy / oral squamous cell carcinoma / neck dissection / EGFR / マクロピノサイトーシス / マイクロピノサイトーシス / 細胞老化 / SASP / バイオマーカー / ファージライシン療法 / 結核菌 / 抗酸菌 / スメグマ菌 / ファージ療法 / 溶菌酵素 / 抗酸菌ファージ / ライシン / 脂質分解酵素 / 口腔扁平苔癬 / OPMD / 免疫療法 / 免疫チェックポイント阻害剤 / PD-L1 / 口腔がん / がん微小環境 / HPV陽性癌 / 脱ユビキチン化酵素 / HPV陽性がん / 頭頸部癌 / ユビキチン化 / HPV

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