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卲文華

徳島大学

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2026年7月2日更新

職名: 助教
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電子メール: shao.wenhua@tokushima-u.ac.jp
学歴: 2015/9: 桂林医学院修士病理学 ( - 2018. 6.)
2019/4: 徳島大学大学院口腔科学教育部博士課程口腔科学専攻 ( - 2023. 3.)
2019/4: 徳島大学大学院医歯薬学研究部論文博士医学 ( - 2024. 2.)
学位: 博士 / 博士(歯学) (徳島大学) (2023年3月)
職歴・経歴: 2022/8: 徳島大学助教, 大学院医歯薬学研究部

専門分野・研究分野: ライフサイエンス (Life sciences) [実験病理学 (Experimental pathology)]
ライフサイエンス (Life sciences) [病態系口腔科学 (Oral medicine (pathology))]

研究者総覧で最新データを確認する

2026年7月2日更新

専門分野・研究分野: ライフサイエンス (Life sciences) [実験病理学 (Experimental pathology)]
ライフサイエンス (Life sciences) [病態系口腔科学 (Oral medicine (pathology))]
担当経験のある授業科目: 病理学(Ⅰ・Ⅱ) (学部)
病理学Ⅰ・病理学Ⅰ実習 (学部)
病理学Ⅱ・病理学Ⅱ実習 (学部)
病理学実習 (学部)
指導経験: 研究者総覧に該当データはありませんでした。

研究者総覧で最新データを確認する

2026年7月2日更新

専門分野・研究分野: ライフサイエンス (Life sciences) [実験病理学 (Experimental pathology)]
ライフサイエンス (Life sciences) [病態系口腔科学 (Oral medicine (pathology))]

研究テーマ: 研究者総覧に該当データはありませんでした。

著書

卲文華, 常山幸一 :
肝臓,
2025年5月.

論文

Soichiro Kinjyo, Yasuhiro Mouri, Wenhua Shao, Satoshi Fukumoto, Eiji Tanaka, Yasusei Kudo and Keiko Miyoshi :
Spatiotemporal profiling of Fat family genes highlights Fat2 as a novel marker of outer enamel epithelium and stratum intermedium.,
Journal of Oral Biosciences, 68, 2, 100766, 2026.

(要約): The Fat gene family, also known as atypical cadherins, contributes to the formation of planar cell polarity, which determines organ shape, size, and polarity. However, their roles in tooth morphogenesis remain unclear. In this study, the aim was to investigate the spatiotemporal expression patterns of Fat1-Fat4 during murine tooth development.Quantitative polymerase chain reaction was performed using total RNA from newborn C57BL/6J murine tissues to determine Fat1-Fat4 expression. In situ hybridization was performed to examine the localization of Fat family transcripts during tooth development from embryonic Day 12.5 to birth. The dental epithelial stem cell line, M3H1, was used as an in vitro differentiation model, and small-interfering-RNA-mediated knockdown of Fat2 was performed to assess its function. Public single-cell RNA-sequence (scRNA-seq) datasets were analyzed to confirm cell-type specificity.All Fat genes were expressed in the teeth, with Fat2 having the highest level among tissues examined. Fat1 was expressed in the epithelial and mesenchymal cells, and Fat2 expression was restricted to the outer enamel epithelium (OEE) and stratum intermedia (SI). Fat3 and Fat4 were expressed in the dental mesenchyme. In M3H1 cells, Fat1 and Fat2 had biphasic expression at undifferentiated and differentiated stages. Fat2 knockdown decreased Sox2 and nephronectin expression, and increased Foxj1 expression. scRNA-seq supported Fat2 specificity in the OEE and SI.Fat genes have cell-type-specific and developmentally regulated expression during tooth development. Among them, Fat2 emerges as a novel marker of OEE and SI, and it may contribute to epithelial identity and differentiation during odontogenesis.
(キーワード): Animals / Mice / Mice, Inbred C57BL / Odontogenesis / Dental Enamel / Cell Differentiation / Gene Expression Regulation, Developmental / Biomarkers / Epithelium / Cell Line
(徳島大学機関リポジトリ): ● Metadata: 2014135
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.job.2026.100766
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 41862271; ● Search Scopus @ Elsevier (PMID): 41862271; ● Search Scopus @ Elsevier (DOI): 10.1016/j.job.2026.100766

(徳島大学機関リポジトリ: 2014135, DOI: 10.1016/j.job.2026.100766, PubMed: 41862271) Takaaki Tsunematsu, Yasuhiro Mouri, Wenhua Shao, Rieko Arakaki, Jan G. Ruppert, Kensaku Murano, Naozumi Ishimaru, Daniele Guardavaccaro, Michele Pagano and Yasusei Kudo :
Sustained chromosomal passenger complex activity preserves the pluripotency of human embryonic carcinoma cells,
Science Signaling, 18, 874, 2025.

(出版サイトへのリンク): ● Publication site (DOI): 10.1126/scisignal.adg4626
(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-85218629117

(DOI: 10.1126/scisignal.adg4626, Elsevier: Scopus) Orgil Jargalsaikhan, Wenhua Shao, Mayuko Shimizu, Soichiroh Ishimaru, Takaaki Koma, Masako Nomaguchi, Hirohisa Ogawa, Shotaroh Tachibana, Battogtokh Chimeddorj, Khongorzul Batchuluun, Anujin Tseveenjav, Battur Magvan, Bayarmaa Enkhbat, Sayamaa Lkhagvadorj, Adilsaikhan Mendjargal, Lkhagvadulam Ganbaatar, Minoru Irahara, Masashi Akaike, Damdindorj Boldbaatar and Koichi Tsuneyama :
Histopathological Features of Hepatocellular Carcinoma in Patients with Hepatitis B and D Virus Infection: A Single-Institution Study in Mongolia.,
Cancers, 17, 3, 432, 2025.

(要約): : Based on this clinicopathological study, CD4 and CD8 immunostaining can be considered an adjunctive diagnostic tool in cases with significant lymphocytic infiltration and hepatocellular damage. Additionally, HDV screening using blood and tissue samples may be recommended to ensure accurate diagnosis.
(徳島大学機関リポジトリ): ● Metadata: 2014086
(出版サイトへのリンク): ● Publication site (DOI): 10.3390/cancers17030432
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 39941800; ● Summary page in Scopus @ Elsevier: 2-s2.0-85217523532

(徳島大学機関リポジトリ: 2014086, DOI: 10.3390/cancers17030432, PubMed: 39941800, Elsevier: Scopus) Orgil Jargalsaikhan, Wenhua Shao, Mayuko Shimizu, Soichiro Ishimaru, Takaaki Koma, Masako Nomaguchi, Battogtokh Chimeddorj, Khongorzul Batchuluun, Ganzorig Batbaatar, Gankhuu Gankhuyag, Saruul Gerelchuluun, Minoru Irahara, Masashi Akaike and Koichi Tsuneyama :
Analysis of 69 Hepatocellular Carcinoma Cases from the National Center for Pathology in Mongolia : A Comprehensive Study of Samples Collected Nationwide.,
The Journal of Medical Investigation : JMI, 72, 1.2, 47-53, 2025.

(要約): The high rate of chronic hepatitis, including hepatitis B, C and D, in Mongolia creates a large health burden of advanced liver disease. This includes liver failure and the highest incidence rate of hepatocellular carcinoma (HCC) worldwide. In the present study, we histopathologically examined 69 recent cases of HCC from the Mongolian National Center for Pathology, which collects specimens from across the country. The background liver histology of HCC exhibited a bimodal distribution, with one peak corresponding to advanced liver fibrosis and another to mild liver fibrosis. The fibrosis severity negatively correlated with age. Additionally, the frequency of poorly differentiated tumors was significantly higher in the HCC with early stage of fibrosis. A comparison of the pathological characteristics of HCC in urban and rural areas showed that poorly differentiated tumors were highly prevalent in urban areas. The characteristics of HCC in Mongolia are different from those in other countries, suggesting that the causes of liver disease are not only related to viruses but also other factors that depend on the region. This study will provide insight into what research is needed next for liver cancer control in Mongolia. J. Med. Invest. 72 : 47-53, February, 2025.
(キーワード): Humans / Carcinoma, Hepatocellular / Liver Neoplasms / Mongolia / 男性 (male) / Middle Aged / 女性 (female) / Aged / Adult / Liver Cirrhosis / Aged, 80 and over
(徳島大学機関リポジトリ): ● Metadata: 2013282
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.72.47
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 40268455; ● Summary page in Scopus @ Elsevier: 2-s2.0-105003982065

(徳島大学機関リポジトリ: 2013282, DOI: 10.2152/jmi.72.47, PubMed: 40268455, Elsevier: Scopus) Wenhua Shao, Hitomi Kamo, Kazuo Yoshioka, Keisuke Izumi and Koichi Tsuneyama :
Cholangiolocellular Carcinoma Misdiagnosed As Hemangioma: Unique Central Fibrotic Area Devoid of Cancer Cells Detected on a Seven-Year Follow-Up,
Curēus, 16, 11, 2024.

(要約): Cholangiolocellular carcinoma, a subtype of peripheral-type intrahepatic cholangiocarcinoma, is a relatively rare primary liver tumor. This case report describes a patient with cholangiolocellular carcinoma that was initially misdiagnosed as hemangioma, and ultimately underwent complete tumor resection after a seven-year follow-up period. A 72-year-old female patient with a history of chronic hepatitis C was followed up regularly at the hospital. Computed tomography (CT) performed seven years prior had detected a small tumor (12 mm) with radiographic characteristics suggestive of hemangioma. The tumor increased in size from 12 to 32 mm over the next seven years. On CT, the tumor showed poor central enhancement, indicating reduced blood flow in the central region. Due to the suspicion of malignancy, partial surgical resection was performed. Pathological examination confirmed a diagnosis of cholangiolocellular carcinoma. The carcinoma exhibited vascular invasion and a broad central fibrous area with hyalinization, lacking epithelial cells, and marked by venous obstruction. This case underscores the challenge of distinguishing cholangiolocellular carcinoma from hemangioma, particularly in small tumors with similar radiological features. The findings highlight the importance of employing additional diagnostic modalities such as ultrasound and magnetic resonance imaging, as well as the necessity of biopsy when suspicion arises. This case also describes the unique finding of a central fibrous area without tumor cells, which may have resulted from localized circulatory disturbances potentially caused by tumor embolism in the portal and hepatic veins. This pathological finding provides valuable insights into the nature of this rare tumor.
(出版サイトへのリンク): ● Publication site (DOI): 10.7759/cureus.73091
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 39650917; ● Search Scopus @ Elsevier (PMID): 39650917; ● Search Scopus @ Elsevier (DOI): 10.7759/cureus.73091

(DOI: 10.7759/cureus.73091, PubMed: 39650917) Jianfeng Zheng, Xiaoyu Zhang, Yaqiang Xue, Wenhua Shao, Yaxun Wei, Sisi Mi, Xiaojie Yang, Linan Hu, Yi Zhang and Ming Liang :
PAIP1 binds to pre-mRNA and regulates alternative splicing of cancer pathway genes including VEGFA,
BMC Genomics, 25, 1, 926, 2024.

(要約): Poly (A) binding protein interacting protein 1 (PAIP1) has been shown to causally contribute to the development and progression of cancer. However, the mechanisms of the PAIP1 regulation in tumor cells remain poorly understood. Here, we used a recently developed UV cross-linking and RNA immunoprecipitation method (iRIP-seq) to map the direct and indirect interaction sites between PAIP1 and RNA on a transcriptome-wide level in HeLa cells. We found that PAIP1 not only binds to 3'UTRs, but also to pre-mRNAs/mRNAs with a strong bias towards the coding region and intron. PAIP1 binding sites are enriched in splicing enhancer consensus GA-rich motifs. RNA-seq analysis revealed that PAIP1 selectively modulates the alternative splicing of genes in some cancer hallmarks including cell migration, the mTOR signaling pathway and the HIF-1 signaling pathway. PAIP1-regulated alternative splicing events were strongly associated with PAIP1 binding, demonstrating that the binding may promote selection of the nearby splice sites. Deletion of a PAIP1 binding site containing seven repeats of GA motif reduced the PAIP1-mediated suppression of the exon 6 inclusion in a VEGFA mRNA isoform. Proteomic analysis of the PAIP1-interacted proteins revealed the enrichment of the spliceosome components and splicing factors. These findings suggest that PAIP1 is both a polyadenylation and alternative splicing regulator, that may play a large role in RNA processing via its role in alternative splicing regulation.
(キーワード): Alternative splicing / PAIP1 / RNA binding protein / RNA immunoprecipitation / VEGFA
(出版サイトへのリンク): ● Publication site (DOI): 10.1186/s12864-024-10530-9
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 39363305; ● Summary page in Scopus @ Elsevier: 2-s2.0-85205606008

(DOI: 10.1186/s12864-024-10530-9, PubMed: 39363305, Elsevier: Scopus) Motoharu Sarubo, Yasuhiro Mouri, Akira Moromizato, Azusa Yamada, Shengjan Jin, Wenhua Shao, Hiroko Hagita, Keiko Miyoshi and Yasusei Kudo :
Involvement of TGFBI-TAGLN axis in cancer stem cell property of head and neck squamous cell carcinoma.,
Scientific Reports, 14, 1, 6767, 2024.

(要約): Head and neck squamous cell carcinoma (HNSCC) is a significant healthcare burden globally. Previous research using single-cell transcriptome analysis identified TGFBI as a crucial marker for the partial-epithelial-mesenchymal transition (partial-EMT) program. However, the precise role of TGFBI in HNSCC progression remains unclear. Therefore, our study aimed to clarify the impact of TGFBI on the malignant behavior of HNSCC cells. Through RNA-sequencing data from the TCGA database, we validated that increased TGFBI expression correlates with a higher occurrence of lymph node metastasis and unfavorable prognosis in HNSCC cases. Functional experiments demonstrated that TGFBI overexpression enhances the ability of sphere formation, indicating stem-cell-like properties. Conversely, TGFBI depletion reduces sphere formation and suppresses the expression of cancer stem cell (CSC) markers. RNA-sequencing analysis of TGFBI-overexpressing and control HNSCC cells revealed TAGLN as a downstream effector mediating TGFBI-induced sphere formation. Remarkably, TAGLN depletion abolished TGFBI-induced sphere formation, while its overexpression rescued the suppressed sphere formation caused by TGFBI depletion. Moreover, elevated TAGLN expression showed correlations with the expression of TGFBI and partial-EMT-related genes in HNSCC cases. In conclusion, our findings suggest that TGFBI may promote CSC properties through the upregulation of TAGLN. These novel insights shed light on the involvement of the TGFBI-TAGLN axis in HNSCC progression and hold implications for the development of targeted therapies.
(キーワード): Humans / Squamous Cell Carcinoma of Head and Neck / Carcinoma, Squamous Cell / Head and Neck Neoplasms / Cell Line, Tumor / Neoplastic Stem Cells / Epithelial-Mesenchymal Transition / RNA (RNA) / Gene Expression Regulation, Neoplastic
(徳島大学機関リポジトリ): ● Metadata: 2011952
(出版サイトへのリンク): ● Publication site (DOI): 10.1038/s41598-024-57478-0
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38514830; ● Summary page in Scopus @ Elsevier: 2-s2.0-85188230546

(徳島大学機関リポジトリ: 2011952, DOI: 10.1038/s41598-024-57478-0, PubMed: 38514830, Elsevier: Scopus) Shengjian Jin, Takaaki Tsunematsu, Taigo Horiguchi, Yasuhiro Mouri, Wenhua Shao, Keiko Miyoshi, Hiroko Hagita, Motoharu Sarubo, Natsumi Fujiwara, Qi Guangying, Naozumi Ishimaru and Yasusei Kudo :
Involvement of the OTUB1-YAP1 axis in driving malignant behaviors of head and neck squamous cell carcinoma.,
Cancer Medicine, 12, 24, 22156-22169, 2023.

(要約): In HNSCC patients, USP10, USP14, OTUB1, and STAMBP among the screened DUBs were associated with a poor prognosis. Among them, OTUB1 showed the most aggressive characteristics in both in vitro and in vivo experiments. Additionally, OTUB1 regulated the stability and nuclear localization of YAP1, a substrate involved in cell proliferation and invasion. Notably, OTUB1 expression exhibited a positive correlation with the HNSCC-YAP score in HNSCC cells.
(キーワード): deubiquitinating enzyme (DUB) / head and neck squamous cell carcinoma / invasion / OTUB1 / YAP
(徳島大学機関リポジトリ): ● Metadata: 2011517
(出版サイトへのリンク): ● Publication site (DOI): 10.1002/cam4.6735
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37986681; ● CiNii @ 国立情報学研究所 (CRID): 1360865816806461952; ● Summary page in Scopus @ Elsevier: 2-s2.0-85177448617

(徳島大学機関リポジトリ: 2011517, DOI: 10.1002/cam4.6735, PubMed: 37986681, CiNii: 1360865816806461952, Elsevier: Scopus) Wenhua Shao, Mayuko Shimizu, Hirohisa Ogawa, Shengjian Jin, Mitsuko Sutoh, Satoko Nakamura, Miki Onodera, Hirosuke Tawara, Shunji Toyohara, Ryoji Hokao, Yasusei Kudo, Takeshi Oya and Koichi Tsuneyama :
Establishment of repeated liver biopsy technique in experimental mice.,
Heliyon, 9, 6, e16978, 2023.

(要約): Biopsy is a commonly used method for determining pathological diagnoses by directly using human tissues and cells. Biopsies are widely used to determine disease progression and treatment efficacy. Although organs and tissues are usually obtained by sacrifice during animal experiments, it is theoretically possible to use the same biopsy techniques in humans. In the present study, we examined the feasibility of performing four repeated liver biopsies in a spontaneous metabolic syndrome mouse model. Even though a small number of mice died accidently, most mice were able to undergo four liver biopsies without significant adverse events. We also performed three liver biopsies in mouse liver tumor carcinogen models at 4, 8, and 12 weeks of age. In addition to the sample collected at 16 weeks of age during sacrifice, we successfully collected four liver samples from the same mice at different stages of disease progression. The application of this liver biopsy technique might make it possible for direct evaluation of pathological conditions in the same individual over time, thereby reducing the number of experimental animals.
(徳島大学機関リポジトリ): ● Metadata: 2011684
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.heliyon.2023.e16978
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37484353; ● Summary page in Scopus @ Elsevier: 2-s2.0-85161065015

(徳島大学機関リポジトリ: 2011684, DOI: 10.1016/j.heliyon.2023.e16978, PubMed: 37484353, Elsevier: Scopus) Wenhua Shao, Takaaki Tsunematsu, Masaaki Umeda, Hiroaki Tawara, Natsumi Fujiwara, Yasuhiro Mouri, Rieko Arakaki, Naozumi Ishimaru and Yasusei Kudo :
Cancer cell-derived novel periostin isoform promotes invasion in head and neck squamous cell carcinoma.,
Cancer Medicine, 12, 7, 8510-8525, 2023.

(要約): It recently has been reported that partial-epithelial-mesenchymal transition (p-EMT) program is associated with metastasis in head and neck squamous cell carcinoma (HNSCC). We previously have identified POSTN (which encodes periostin) as an invasion-promoting molecule in HNSCC. Interestingly, POSTN expression is frequently observed in cancer cells with higher p-EMT score by using a previous single-cell transcriptomic data of HNSCC cases. Although it is known that POSTN has 11 splicing variants, the role of them has not been determined in HNSCC. Here, we found that HNSCC cells with EMT features expressed POSTN isoforms, Iso3 (lacking exon 17 and 21) and Iso5 (lacking exon 17), whereas fibroblast expressed Iso3 and Iso4 (lacking exon 17, 18, and 21). The expression of POSTN Iso3 and Iso4 are known to be widely observed in various cell types including stromal cells. Therefore, we focused on the role of novel cancer cell-derived POSTN isoform, Iso5, in HNSCC. Single overexpression of POSTN Iso5 as well as Iso3 promoted invasion. Surprisingly, Iso5 synergistically promoted invasion together with Iso3. Notably, Iso5 as well as Iso3 upregulated p-EMT-related genes. We suggest that a novel cancer-specific POSTN isoform lacking exon 17 (Iso5) can be a useful marker for detecting cancer cells undergoing p-EMT. Moreover, a POSTN Iso5 can be a novel target for diagnosis and therapy in HNSCC.
(徳島大学機関リポジトリ): ● Metadata: 2011067
(出版サイトへのリンク): ● Publication site (DOI): 10.1002/cam4.5601
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36691359; ● Search Scopus @ Elsevier (PMID): 36691359; ● Search Scopus @ Elsevier (DOI): 10.1002/cam4.5601

(徳島大学機関リポジトリ: 2011067, DOI: 10.1002/cam4.5601, PubMed: 36691359) Wenhua Shao, Orgil Jargalsaikhan, Mayuko Shimizu, Qinyi Cai, Hirohisa Ogawa, Yuko Miyakami, Kengo Atsumi, Mitsuru Tomita, Mitsuko Sutoh, Shunji Toyohara, Ryoji Hokao, Yasusei Kudo, Takeshi Oya and Koichi Tsuneyama :
Spontaneous Occurrence of Various Types of Hepatocellular Adenoma in the Livers of Metabolic Syndrome-Associated Steatohepatitis Model TSOD Mice.,
International Journal of Molecular Sciences, 23, 19, 2022.

(要約): Male Tsumura-Suzuki Obese Diabetes (TSOD) mice, a spontaneous metabolic syndrome model, develop non-alcoholic steatohepatitis and liver tumors by feeding on a standard mouse diet. Nearly 70% of liver tumors express glutamine synthetase (GS), a marker of hepatocellular carcinoma. In contrast, approximately 30% are GS-negative without prominent nuclear or structural atypia. In this study, we examined the characteristics of the GS-negative tumors of TSOD mice. Twenty male TSOD mice were sacrificed at 40 weeks and a total of 21 tumors were analyzed by HE staining and immunostaining of GS, liver fatty acid-binding protein (L-FABP), serum amyloid A (SAA), and beta-catenin. With immunostaining for GS, six (29%) tumors were negative. Based on the histological and immunohistological characteristics, six GS-negative tumors were classified into several subtypes of human hepatocellular adenoma (HCA). One large tumor showed generally similar findings to inflammatory HCA, but contained small atypical foci with GS staining and partial nuclear beta-catenin expression suggesting malignant transformation. GS-negative tumors of TSOD mice contained features similar to various subtypes of HCA. Different HCA subtypes occurring in the same liver have been reported in humans; however, the diversity of patient backgrounds limits the ability to conduct a detailed, multifaceted analysis. TSOD mice may share similar mechanisms of HCA development as in humans. It is timely to review the pathogenesis of HCA from both genetic and environmental perspectives, and it is expected that TSOD mice will make further contributions in this regard.
(キーワード): Adenoma, Liver Cell / Animals / Carcinoma, Hepatocellular / 糖尿病 (diabetes mellitus) / Fatty Acid-Binding Proteins / Glutamate-Ammonia Ligase / Humans / 免疫組織化学 (immunohistochemistry) / Liver Neoplasms / 男性 (male) / Metabolic Syndrome / Mice / Mice, Obese / Non-alcoholic Fatty Liver Disease / Serum Amyloid A Protein / beta Catenin
(徳島大学機関リポジトリ): ● Metadata: 2011597
(出版サイトへのリンク): ● Publication site (DOI): 10.3390/ijms231911923
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36233225; ● Summary page in Scopus @ Elsevier: 2-s2.0-85139812612

(徳島大学機関リポジトリ: 2011597, DOI: 10.3390/ijms231911923, PubMed: 36233225, Elsevier: Scopus) Wenhua Shao, Natsumi Fujiwara, Yasuhiro Mouri, Satoru Kisoda, Kayo Yoshida, Kaya Yoshida, Hiromichi Yumoto, Kazumi Ozaki, Naozumi Ishimaru and Yasusei Kudo :
Conversion from epithelial to partial-EMT phenotype by Fusobacterium nucleatum infection promotes invasion of oral cancer cells.,
Scientific Reports, 11, 1, 14943, 2021.

(要約): The ability of cancer cells to undergo partial-epithelial mesenchymal transition (p-EMT), rather than complete EMT, poses a higher metastatic risk. Although Fusobacterium nucleatum mainly inhabits in oral cavity, attention has been focused on the F. nucleatum involvement in colorectal cancer development. Here we examined the p-EMT regulation by F. nucleatum in oral squamous cell carcinoma (OSCC) cells. We cultured OSCC cells with epithelial, p-EMT or EMT phenotype with live or heat-inactivated F. nucleatum. Expression of the genes involved in epithelial differentiation, p-EMT and EMT were examined in OSCC cells after co-culture with F. nucleatum by qPCR. Cell growth and invasion of OSCC cells were also examined. Both live and heat-inactivated F. nucleatum upregulated the expression of p-EMT-related genes in OSCC cells with epithelial phenotype, but not with p-EMT or EMT phenotype. Moreover, F. nucleatum promoted invasion of OSCC cells with epithelial phenotype. Co-culture with other strains of bacteria other than Porphyromonas gingivalis did not alter p-EMT-related genes in OSCC cells with epithelial phenotype. F. nucleatum infection may convert epithelial to p-EMT phenotype via altering gene expression in OSCC. Oral hygiene managements against F. nucleatum infection may contribute to reduce the risk for an increase in metastatic ability of OSCC.
(徳島大学機関リポジトリ): ● Metadata: 2009347
(出版サイトへのリンク): ● Publication site (DOI): 10.1038/s41598-021-94384-1
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34294795; ● Summary page in Scopus @ Elsevier: 2-s2.0-85111135598

(徳島大学機関リポジトリ: 2009347, DOI: 10.1038/s41598-021-94384-1, PubMed: 34294795, Elsevier: Scopus) Satoru Kisoda, Wenhua Shao, Natsumi Fujiwara, Yasuhiro Mouri, Takaaki Tsunematsu, Shengjian Jin, Rieko Arakaki, Naozumi Ishimaru and Yasusei Kudo :
Prognostic value of partial EMT-related genes in head and neck squamous cell carcinoma by a bioinformatic analysis.,
Oral Diseases, 26, 6, 1149-1156, 2020.

(要約): Our findings suggest that p-EMT program may be involved in poor prognosis of HNSCC. SERPINE1, ITGA5, TGFBI, P4HA2, CDH13, and LAMC2 can be used for a prognostic marker. Moreover, HNSCC cells with p-EMT phenotype can be a useful model for investigating a nature of p-EMT.
(徳島大学機関リポジトリ): ● Metadata: 2007901
(出版サイトへのリンク): ● Publication site (DOI): 10.1111/odi.13351
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32277532; ● Summary page in Scopus @ Elsevier: 2-s2.0-85083974773

(徳島大学機関リポジトリ: 2007901, DOI: 10.1111/odi.13351, PubMed: 32277532, Elsevier: Scopus) Kunihiro Otsuka, Akiko Yamada, Masako Saito, Aya Ushio, Mami Sato, Satoru Kisoda, Wenhua Shao, Takaaki Tsunematsu, Yasusei Kudo, Rieko Arakaki and Naozumi Ishimaru :
Ascl2-Regulated Follicular Helper T Cells Promote Autoimmunity in a Murine Model for Sjögren's Syndrome.,
The American Journal of Pathology, 189, 12, 2414-2427, 2019.

(要約): mice that received neonatal thymectomy treatment demonstrated that Ascl2 contributes to the Tfh cell differentiation associated with autoimmunity during the early stages independent of Bcl6. In conclusion, our results indicate that abnormal Tfh cell differentiation via Ascl2 regulation might contribute to the pathogenesis of autoimmunity.
(キーワード): Animals / Autoantibodies / 自己免疫 (autoimmunity) / B-Lymphocytes / Basic Helix-Loop-Helix Transcription Factors / 細胞分化 (cell differentiation) / Cytokines / Disease Models, Animal / 女性 (female) / Germinal Center / Mice / Mice, Inbred C57BL / Proto-Oncogene Proteins c-bcl-6 / シェーグレン症候群 (Sjögren's syndrome) / T-Lymphocytes, Helper-Inducer
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.ajpath.2019.08.008
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31539517; ● Summary page in Scopus @ Elsevier: 2-s2.0-85075213858

(DOI: 10.1016/j.ajpath.2019.08.008, PubMed: 31539517, Elsevier: Scopus) Yaping Ren, Wenhua Shao, Lijun Zuo, Wei Zhao, Haizhang Qin, Yingjie Hua, Dejie Lu, Chao Mi, Sien Zeng and Liao Zu :
Mechanism of cadmium poisoning on testicular injury in mice.,
Oncology Letters, 18, 2, 1035-1042, 2019.

(要約): Cadmium is a heavy metal that is toxic to humans and the reproductive system. The present study aimed to investigate the mechanisms of cadmium-induced reproductive toxicity in a male Institute of Cancer Research mouse model of cadmium poisoning. Changes in luteinizing hormone receptor (LHR), 17α-hydroxylase and endothelial nitric oxide (NO) synthase (eNOS) expression levels were examined. A total of 24 male mice (4-week-old) were randomly divided into four groups (normal control group and low, medium and high cadmium groups) and subjected to gavage treatment with normal saline or cadmium-containing saline solutions for 8 weeks prior to sacrifice. To assess testicular injury, serum androgen levels were determined by ELISA, testicular tissue pathological changes were evaluated using hematoxylin and eosin staining. In addition, LHR, 17α-hydroxylase and eNOS expressions levels were examined by western blotting, and apoptosis was examined with a terminal deoxynucleotidyl transferase dUTP nick end labeling assay. The results demonstrated that the severity of testes injury increased with cadmium concentration. In addition, LHR, 17α-hydroxylase and eNOS expression levels increased with low and medium concentrations of cadmium; however, they were decreased following treatment with high concentrations of cadmium. The results from the present study demonstrated that cadmium altered LHR, 17α-hydroxylase and eNOS expression levels in testicular stromal cells, which may impact testosterone synthesis. Furthermore, NO was suggested to be involved in cadmium-induced testicular injury by measurements of eNOS expression in testicular stromal cells.
(出版サイトへのリンク): ● Publication site (DOI): 10.3892/ol.2019.10418
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31423163; ● Search Scopus @ Elsevier (PMID): 31423163; ● Search Scopus @ Elsevier (DOI): 10.3892/ol.2019.10418

(DOI: 10.3892/ol.2019.10418, PubMed: 31423163) Tian Liu, Jing Liu, Qiuyue Chen, Shengjian Jin, Sisi Mi, Wenhua Shao, Yasusei Kudo, Sien Zeng and Guangying Qi :
Expression of USP22 and the chromosomal passenger complex is an indicator of malignant progression in oral squamous cell carcinoma.,
Oncology Letters, 17, 2, 2040-2046, 2018.

(要約): Oral cancer is a common cancer of the head and neck. Oral squamous cell carcinoma (OSCC) represents almost 90% of the total cases of head and neck cancer. Ubiquitin-specific protease 22 (USP22) is a deubiquitinating hydrolase, and it is highly expressed in various types of cancer, which also typically have a poor prognosis. Aurora-B and Survivin, which belong to the chromosomal passenger complex, are also highly expressed in a number of types of cancer. In the present study, USP22 expression and its associations with Aurora-B and Survivin, and the clinicopathological features in OSCC were explored. USP22 is highly expressed in OSCC. Overexpression of USP22 is associated with lymph node metastasis and histological grade (P<0.01). Additionally, the expression of USP22 was positively associated with Aurora-B (P<0.01), Survivin (P<0.01), and Ki-67 (P<0.01). Furthermore, USP22 small interfering RNA inhibited cell growth and reduced the expression levels of Aurora-B, Survivin and Cyclin B, together with the upregulation of cyclin-dependent kinase inhibitor 1A (p21). These data suggest that USP22, Aurora-B and Survivin promote the OSCC development and may represent novel targets for OSCC diagnosis and treatment in the future.
(徳島大学機関リポジトリ): ● Metadata: 2008589
(出版サイトへのリンク): ● Publication site (DOI): 10.3892/ol.2018.9837
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30675271; ● Summary page in Scopus @ Elsevier: 2-s2.0-85059632421

(徳島大学機関リポジトリ: 2008589, DOI: 10.3892/ol.2018.9837, PubMed: 30675271, Elsevier: Scopus) Haipeng Wang, Shengjian Jin, Huiling Lu, Sisi Mi, Wenhua Shao, Xiaoxv Zuo, Huangyi Yin, Sien Zeng, Fumio Shimamoto and Guangying Qi :
Expression of survivin, MUC2 and MUC5 in colorectal cancer and their association with clinicopathological characteristics.,
Oncology Letters, 14, 1, 1011-1016, 2017.

(要約): Survivin is a bifunctional protein that suppresses apoptosis and regulates cell division, and is highly expressed in various cancer types. Mucins are high-molecular-weight, heavily glycosylated proteins. In the present study, the association between survivin, mucin 2 (MUC2) and MUC5 expression, and the clinicopathological features of colorectal cancer (CRC) were investigated. The immunohistochemistry and western blotting results demonstrated that survivin was highly expressed in CRC tissues and rarely expressed in normal colon tissues. Moreover, the overexpression of survivin and MUC5 was strongly associated with lymph node metastasis, poor cellular differentiation, advanced tumor stage and a poor prognosis in CRC. By contrast, low expression of MUC2 was significantly associated with lymph node metastasis, poor cellular differentiation and an advanced tumor stage in CRC. The results of the present study suggest that survivin, MUC2 and MUC5 levels may be associated with tumor progression and could be used to aid the early diagnosis and clinical characterization of CRC.
(出版サイトへのリンク): ● Publication site (DOI): 10.3892/ol.2017.6218
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28693267; ● Search Scopus @ Elsevier (PMID): 28693267; ● Search Scopus @ Elsevier (DOI): 10.3892/ol.2017.6218

(DOI: 10.3892/ol.2017.6218, PubMed: 28693267) Guangying Qi, Jian Chen, Changrong Shi, Yukun Wang, Sisi Mi, Wenhua Shao, Xiangyuan Yu, Yili Ma, Jiapu Ling and Jian Huang :
Cinnamic Acid (CINN) Induces Apoptosis and Proliferation in Human Nasopharyngeal Carcinoma Cells.,
Cellular Physiology and Biochemistry, 40, 3-4, 589-596, 2016.

(要約): CINN inhibits the proliferation and induces the apoptosis of CNE2 cells. Therefore, CINN possesses a potential anti-tumor effect.
(キーワード): Apoptosis / Blotting, Western / Carcinoma / Cell Cycle / Cell Line, Tumor / Cell Proliferation / Cell Shape / Cinnamates / Flow Cytometry / Humans / Nasopharyngeal Carcinoma / Nasopharyngeal Neoplasms
(出版サイトへのリンク): ● Publication site (DOI): 10.1159/000452572
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27889776; ● Search Scopus @ Elsevier (PMID): 27889776; ● Search Scopus @ Elsevier (DOI): 10.1159/000452572

(DOI: 10.1159/000452572, PubMed: 27889776) Chunbo Xia, Lin Zhu, Wenhua Shao, Sisi Mi, Sen Du, Lin Ye, Manjun Liu, YongJun Pang, Linlin Nong, Changwen Jiang, Hailu Zhao and Guangying Qi :
The Effect of Hippocampal Cognitive Impairment and XIAP on Glucose and Lipids Metabolism in Rats.,
Cellular Physiology and Biochemistry, 38, 2, 609-618, 2016.

(要約): Cognitive impairment and hippocampal neuron apoptosis can cause glucose and lipids metabolic abnormalities, possibly by regulating gastrointestinal motility and AMPK expression in the liver. The changes in the function of XIAP, which is an anti-apoptotic protein in the hippocampus, may affect the metabolism of glucose and lipids.
(キーワード): AMP-Activated Protein Kinases / Animals / Apoptosis / Blood Glucose / Cognition Disorders / Female / Gastrointestinal Motility / Glucose / Hippocampus / Lipid Metabolism / Lipids / Male / Rats, Sprague-Dawley / X-Linked Inhibitor of Apoptosis Protein
(出版サイトへのリンク): ● Publication site (DOI): 10.1159/000438654
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26845572; ● Search Scopus @ Elsevier (PMID): 26845572; ● Search Scopus @ Elsevier (DOI): 10.1159/000438654

(DOI: 10.1159/000438654, PubMed: 26845572)

MISC

Hidesuke Tada, Wenhua Shao, Naozumi Ishimaru and Yasusei Kudo :
The life in Japan and status of private dental office at the times of COVID-19.,
Oral Diseases, 27 Suppl 3, 727-729, 2020.

(キーワード): COVID-19 / Dental Offices / Humans / 日本 (Japan) / SARS-CoV-2
(徳島大学機関リポジトリ): ● Metadata: 2007900
(出版サイトへのリンク): ● Publication site (DOI): 10.1111/odi.13449
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32475028; ● Summary page in Scopus @ Elsevier: 2-s2.0-85087066066

(徳島大学機関リポジトリ: 2007900, DOI: 10.1111/odi.13449, PubMed: 32475028, Elsevier: Scopus)

総説・解説

Guangying Qi, Jing Liu, Sisi Mi, Takaaki Tsunematsu, Shengjian Jin, Wenhua Shao, Tian Liu, Naozumi Ishimaru, Bo Tang and Yasusei Kudo :
Aurora Kinase Inhibitors In Head And Neck Cancer.,
Current Topics in Medicinal Chemistry, 18, 3, 199-213, Jan. 2018.

(要約): Aurora kinases are a group of serine/threonine kinases responsible for the regulation of mitosis. In recent years, with the increase in Aurora kinase-related research, the important role of Aurora kinases in tumorigenesis has been gradually recognized. Aurora kinases have been regarded as a new target for cancer therapy, resulting in the development of Aurora kinase inhibitors. The study and application of these small-molecule inhibitors, especially in combination with chemotherapy drugs, represents a new direction in cancer treatment. This paper reviews studies on Aurora kinases from recent years, including studies of their biological function, their relationship with tumor progression, and their inhibitors.
(徳島大学機関リポジトリ): ● Metadata: 2006618
(出版サイトへのリンク): ● Publication site (DOI): 10.2174/1568026618666180112163741
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29332580; ● Summary page in Scopus @ Elsevier: 2-s2.0-85047777413

(徳島大学機関リポジトリ: 2006618, DOI: 10.2174/1568026618666180112163741, PubMed: 29332580, Elsevier: Scopus)

講演・発表

Wenhua Shao, Mayuko Shimizu, Jargalsaikhan Orgil, Shengjun Xiao, Cai Li, Shuiwen Tang, Shibo Wang and Koichi Tsuneyama :
Clinicopathological Features of Liver Tumors in Guilin: A Region with Significant Aflatoxin Contamination in Food Crops in China,
May 2025. Koichi Tsuneyama, Wenhua Shao and Mayuko Shimizu :
Various type of hepatocellular adenomas occurred spontaneously in the liver of metabolic syndrome-associated steatohepatitis model, TSOD mice,
AASLD The Liver meeting 2022, Nov. 2022. Wenhua Shao :
徳島での私の生活,
第113回日本病理学会総会, Mar. 2024. Wenhua Shao, Yasuhiro Mouri, Takeshi Oya and Yasusei Kudo :
The role of Fat1 gene mutation in the development of maxillofacial anomalies,
第113回日本病理学会総会, Mar. 2024. 卲文華, 毛利安宏, 尾矢剛志, 工藤保誠 :
The novel function of Fat1 gene mutation in the development of maxillofacial anomalies,
第129回日本解剖学会総会・全国学術集会, 2024年3月. Jin Shengjian, 常松貴明, 堀口大吾, 毛利安宏, 卲文華, 三好圭子, 水澤典子, Hagita Hiroko, 猿棒元陽, 吉田佳世, 吉田賀弥, 藤原奈津美, 尾崎和美, 石丸直澄, 工藤保誠 :
頭頸部扁平上皮癌(HNSCC)の進行における脱ユビキチン化酵素 OTUB1 の役割,
第82回日本癌学会学術集会, 2023年9月. 猿棒元陽, 諸見里昭, 山田梓紗, 卲文華, Jin Shengjian, 毛利安宏, 工藤保誠 :
頸部扁平上皮癌の partial-EMT における TGFBI の役割,
第82回日本癌学会学術総会, 2023年9月. Wenhua Shao, Yasuhiro Mouri and Yasusei Kudo :
The role of Fat1 in maxillofacial development,
第112回日本病理学会総会, Apr. 2023. Jin Shengjian, Takaaki Tsunematsu, Taigo Horiguchi, Yasuhiro Mouri, Wenhua Shao, Keiko Miyoshi, Noriko Mizusawa, Hiroko Hagita, YOSHIDA Kayo, Kaya Yoshida, Natsumi Fujiwara, Kazumi Ozaki, Naozumi Ishimaru and Yasusei Kudo :
The role of Deubiquitinating enzyme, OTUB1 in head and neck squamous cell carcinoma (HNSCC) progression,
第61回四国歯学会, Mar. 2023. 猿棒元陽, 山田梓紗, 卲文華, 金晟劍, 毛利安宏, 工藤保誠 :
Transforming growth factor beta-induced (TGFBI)の役割,
第61回四国歯学会, 2023年3月. Wenhua Shao, Yasuhiro Mouri and Yasusei Kudo :
The novel function of Fat1 in maxillofacial development,
第45回日本分子生物学会年会, Dec. 2022. Sarubou Motoharu, 卲文華, 毛利安宏, 工藤保誠 :
口腔癌の進展における TGFβ1の役割,
第45回日本分子生物学会年会, 2022年12月. Wenhua Shao, Yasuhiro Mouri and Yasusei Kudo :
額顔面形成におけるFat1の役割,
第64回歯科基礎医学会学術大会, Sep. 2022. 大本美奈, 寺島実遥, 三宅夏穂, 森内快郁, 卲文華, 毛利安宏, 工藤保誠 :
阻害剤スクリーニングによる多能性制御因子の同定,
第64回歯科基礎医学会学術大会, 2022年9月. Wenhua Shao, Yasuhiro Mouri and Yasusei Kudo :
The role of Fat1 gene mutation in maxillofacial dysplasia,
第111回日本病理学会総会, Apr. 2022. 卲文華, 藤原奈津美, 毛利安宏, 工藤保誠 :
フソバクテリウム・ヌクレアタム感染による上皮性からp-EMT表現型への変換は，口腔癌細胞の浸潤を促進する,,
第44回日本分子生物学会年会, 2021年12月. 木曽田暁, 卲文華, 金晟劍, 毛利安宏, 工藤保誠 :
クロスプラットフォーム正規化と機械学習を利用した頭頚部扁平上皮癌の予後予測モデルの構築,
第80回日本癌学会学術総会, 2021年10月. 大塚邦紘, 山田安希子, 齋藤雅子, 牛尾綾, 佐藤真美, 木曽田暁, 卲文華, 常松貴明, 工藤保誠, 新垣理恵子, 石丸直澄 :
Achaete-Scute Homologue 2-Regulated Follicular Helper T Cells Promote Autoimmunity in a Murine Model for Sjögren Syndrome.,
第32回日本臨床口腔病理学会奨励賞(実験病理分野), 2021年8月. 山村佳子, 工藤保誠, 毛利安宏, 卲文華, 横田美保, 宮本洋二 :
腺房細胞の再生に関わる遺伝子ネットワークの同定,
第75回日本口腔科学会学術集会, 2021年5月. 木曽田暁, 卲文華, Jin Shengjian, 常松貴明, 石丸直澄, 工藤保誠 :
頭頸部扁平上皮癌の予後を予測する新規システムの構築,
第79回日本癌学会学術総会, 2020年10月. Wenhua Shao, Umeda Masaaki, Takaaki Tsunematsu, Kisoda Satoru and Naozumi Ishimaru :
Novel periostin inform promotes invasion and metastasis in head and neck squamous cell carcinoma.,
第109回日本病理学会総会, Jul. 2020. 木曽田暁, 卲文華, 常松貴明, 石丸直澄, 工藤保誠 :
口腔癌におけるpartial-EMTに関連する遺伝子の悪性度への関与,
第78回日本癌学会学術総会, 2019年9月. Wenhua Shao, Yuan Jin, Sisi Mi, Guangying Qi and Sien Zeng :
The research of HCG in the proliferation , invasion and metastasis of colorectal carcinoma,
第38回分子病理研究会, Jul. 2019. Wenhua Shao, Yuan Jin, Sisi Mi, guangying Qi and Sien Zeng :
The research of hCG in the proliferation and invasion and metastasis of colorectal carcinoma.,
第38回分子病理研究会, Jul. 2019. 木曽田暁, 卲文華, 牛尾綾, 佐藤真美, 新垣理恵子, 石丸直澄, 工藤保誠 :
口腔癌におけるpartial-EMTに関する遺伝子の悪性度への関与,
第38回分子病理研究会, 2019年7月.

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補助金・競争的資金: 新規Fat1変異マウスを用いた第1咽頭弓形成におけるFAT1の機能解析 (研究課題/領域番号: 26K12620 )
FAT1遺伝子変異がもたらす口腔発がんメカニズムの解明 (研究課題/領域番号: 23K15977 )
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2026年7月2日更新

専門分野・研究分野: ライフサイエンス (Life sciences) [実験病理学 (Experimental pathology)]
ライフサイエンス (Life sciences) [病態系口腔科学 (Oral medicine (pathology))]
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受賞: 2021年7月, 令和3年度口腔科学教育部研究奨励賞ゴールド賞 (徳島大学)
2021年10月, 徳島大学大学院口腔科学教育部中間発表優秀発表賞 (徳島大学)
2021年11月, 細井和留学生奨励奨励賞 (徳島大学大学院口腔科学教育部)
2023年3月, 令和4年優秀学位論文賞 (徳島大学)
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