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渡邊毅

徳島大学

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2024年11月22日更新

職名: 助教
電話: 088-633-7073
電子メール: watanabe.takeshi.2@tokushima-u.ac.jp
学歴: 2004/3: 開成高等学校卒業
2008/3: 一橋大学経済学部経済学科卒業
2008/4: 東京医科歯科大学歯学部歯学科3年次学士編入学
2010/4: 東京医科歯科大学大学院医歯学総合研究科(DDS-PhDコース)入学
2016/3: 東京医科歯科大学歯学部歯学科卒業
学位: 博士(歯学) (東京医科歯科大学大学院医歯学総合研究科) (2018年1月)
職歴・経歴: 2012/4: 日本学術振興会特別研究員(DC2)
2016/4: 東京医科歯科大学歯学部附属病院歯科臨床研修医
2017/4: 東京医科歯科大学歯学部附属病院歯科心身医療外来医員
2018/4: 東京医科歯科大学歯学部附属病院歯科心身医療外来特任助教
2020/4: オーフス大学心理行動科学部(デンマーク)客員研究員(上原記念生命科学財団リサーチフェローシップ)
2021/8: 徳島大学大学院医歯薬学研究部予防医学分野助教

専門分野・研究分野: 歯科学 (Dentistry)
疫学 (Epidemiology)

研究者総覧で最新データを確認する

2024年11月22日更新

専門分野・研究分野: 歯科学 (Dentistry)
疫学 (Epidemiology)
担当経験のある授業科目: プレ配属演習 (学部)
予防医学 (学部)
予防歯科学実習 (学部)
予防歯科学実習 (学部)
社会医学・疫学・医学統計概論 (大学院)
社会医学実習 (学部)
衛生公衆衛生学 (学部)
指導経験: 研究者総覧に該当データはありませんでした。

研究者総覧で最新データを確認する

2024年11月22日更新

専門分野・研究分野: 歯科学 (Dentistry)
疫学 (Epidemiology)

研究テーマ: 歯科におけるノセボ効果の影響 (ノセボ効果, 歯科医学, 慢性疼痛)
生活習慣病
非感染性疾患 (メタボリック症候群, 糖尿病 (diabetes), 代謝表現型)

著書

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論文

Taichi Unohara, Takeshi Watanabe, Kokichi Arisawa, Akari Matsuura, Kahori Kita, Yuka Torii, Masashi Ishizu, Sakurako Katsuura-Kamano, Tien Van Nguyen, Jun Otonari, Hiroaki Ikezaki, Keitaro Tanaka, Chisato Shimanoe, Mako Nagayoshi, Yoko Kubo, Takashi Matsunaga, Rieko Okada, Isao Oze, Hidemi Ito, Nobuaki Michihata, Yohko Nakamura, Shiroh Tanoue, Chihaya Koriyama, Sadao Suzuki, Takeshi Nishiyama, Teruhide Koyama, Etsuko Ozaki, Kiyonori Kuriki, Naoyuki Takashima, Keiko Kondo, Takashi Tamura and Keitaro Matsuo :
Dietary acid load and mortality: Results from the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study,
Research Square, 2024.

(キーワード): 疫学 (epidemiology) / Dietary acid load / 死亡率 (mortality rate) / 心血管疾患 (cardiovascular disease) / 脳血管障害 (cerebrovascular disease)

Naoko Miyagawa, Naoyuki Takashima, Akiko Harada, Aya Kadota, Keiko Kondo, Katsuyuki Miura, Nahomi Imaeda, Chiho Goto, Jun Otonari, Hiroaki Ikezaki, Keitaro Tanaka, Chisato Shimanoe, Mako Nagayoshi, Takashi Tamura, Yoko Kubo, Yasufumi Kato, Yuriko N. Koyanagi, Hidemi Ito, Nobuaki Michihata, Yohko Nakamura, Shiroh Tanoue, Rie Ibusuki, Sadao Suzuki, Takeshi Nishiyama, Etsuko Ozaki, Isao Watanabe, Kiyonori Kuriki, Takeshi Watanabe, Masashi Ishizu, Asahi Hishida, Yoshikuni Kita, Kenji Wakai and Keitaro Matsuo :
Dairy Intake and All-Cause, Cancer, and Cardiovascular Disease Mortality Risk in A Large Japanese Population: A 12-Year Follow-Up of the J-MICC Study,
Journal of Atherosclerosis and Thrombosis, 2024. Takeshi Watanabe, Tien Van Nguyen, Sakurako Katuura-Kamano, Kokichi Arisawa, Masashi Ishizu, Taichi Unohara, Keitaro Tanaka, Chisato Shimanoe, Mako Nagayoshi, Takashi Tamura, Yoko Kubo, Yasufumi Kato, Isao Oze, Hidemi Ito, Nobuaki Michihara, Yohko Nakamura, Shiroh Tanoue, Chihaya Koriyama, Satomi Tomida, Kiyonori Kuriki, Naoyuki Takashimα, Akiko Harada, Kenji Wakai and Keitaro Matsuo :
The Significance of Comprehensive Metabolic Phenotypes in Cancer Risk: A Japan Multi-Institutional Collaborative Cohort (J-MICC) Study.,
Cancer Research Communications, 2024.

(キーワード): 癌 (cancer) / Metabolic phenotypes
(徳島大学機関リポジトリ): ● Metadata: 119641

(徳島大学機関リポジトリ: 119641) Taiki Hori, Ken-ichi Aihara, Takeshi Watanabe, Kaori Inaba, Keisuke Inaba, Yousuke Kaneko, Saki Kawata, Keisuke Kawahito, Hiroki Kita, Kazuma Shimizu, Minae Hosoki, Kensuke Mori, Teruyoshi Kageji, Hideyuki Uraoka and Shingen Nakamura :
The Respiratory Adjusted Shock Index at Admission Is a Valuable Predictor of In-Hospital Outcomes for Elderly Emergency Patients with Medical Diseases at a Japanese Community General Hospital.,
Journal of Clinical Medicine, Vol.13, No.16, 2024.

(要約): : The RASI is a simple indicator that can be used for predicting in-hospital outcomes in elderly emergency patients with medical diseases. Larger prospective studies based on this study are needed.
(徳島大学機関リポジトリ): ● Metadata: 119610
(出版サイトへのリンク): ● Publication site (DOI): 10.3390/jcm13164866
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 39201007; ● Search Scopus @ Elsevier (PMID): 39201007; ● Search Scopus @ Elsevier (DOI): 10.3390/jcm13164866

(徳島大学機関リポジトリ: 119610, DOI: 10.3390/jcm13164866, PubMed: 39201007) Tomoyo Hara, Takeshi Watanabe, Hiroki Yamagami, Kosuke Miyataka, Saya Yasui, Takahito Asai, Yohsuke Kaneko, Yukari Mitsui, Shiho Masuda, Kiyoe Kurahashi, Toshiki Otoda, Tomoyuki Yuasa, Akio Kuroda, Itsuro Endo, Soichi Honda, Akira Kondo, Munehide Matsuhisa and Ken-ichi Aihara :
Development of Liver Fibrosis Represented by the Fibrosis-4 Index Is a Specific Risk Factor for Tubular Injury in Individuals with Type 2 Diabetes,
Biomedicines, Vol.12, No.8, 1789, 2024.

(要約): Although hyperglycemia and hypertension are well-known risk factors for glomerular injury in individuals with type 2 diabetes (T2D), specific risk factors for tubular injury remain unclear. We aimed to clarify the differences between risk factors for glomerular injury and risk factors for tubular injury in individuals with T2D. We categorized 1243 subjects into four groups based on urinary biomarkers, including the albumin-to-creatinine ratio (uACR) and L-type fatty acid-binding protein-to-creatinine ratio (uL-ABPCR) as a normal (N) group (uACR < 30 mg/gCr and uL-FABPCR < 5 μg/gCr; n = 637), a glomerular specific injury (G) group (uACR ≥ 30 mg/gCr and uL-FABPCR < 5 μg/gCr; n = 248), a tubular specific injury (T) group (uACR < 30 mg/gCr and uL-FABPCR ≥ 5 μg/gCr; n = 90), and a dual injury (D) group (uACR ≥ 30 mg/gCr and uL-FABPCR ≥ 5 μg/gCr; n = 268). Logistic regression analysis referencing the N group revealed that BMI, current smoking, and hypertension were risk factors for the G group, creatinine (Cr) and Fibrosis-4 (FIB-4) index were risk factors for the T group, and BMI, hypertension, HbA1c, Cr, and duration of diabetes were risk factors for the D group. While hypertension was a distinct specific risk factor for glomerular injury, the FIB-4 index was a specific contributor to the prevalence of tubular injury. On the other hand, the logistic regression analysis revealed that the hepatic steatosis index (HSI) did not show any significant association with the G group, T group, or D group. Taken together, the development of liver fibrosis rather than liver steatosis is an inherent threat relating to tubular injury in individuals with T2D.
(出版サイトへのリンク): ● Publication site (DOI): 10.3390/biomedicines12081789
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 39200252; ● Summary page in Scopus @ Elsevier: 2-s2.0-85202596205

(DOI: 10.3390/biomedicines12081789, PubMed: 39200252, Elsevier: Scopus) Ryosuke Fujii, Asahi Hishida, Masahiro Nakatochi, Hiroshi Okumiyama, Naoyuki Takashima, Yoshiki Tsuboi, Koji Suzuki, Hiroaki Ikezaki, Chisato Shimanoe, Yasufumi Kato, Takashi Tamura, Hidemi Ito, Nobuaki Michihata, Shiroh Tanoue, Sadao Suzuki, Kiyonori Kuriki, Aya Kadota, Takeshi Watanabe, Yukihide Momozawa, Kenji Wakai and Keitaro Matsuo :
Polygenic risk score for blood pressure and lifestyle factors with overall and CVD mortality: a prospective cohort study in a Japanese population.,
Hypertension Research, 2024.

(要約): Attributable risks of CVD mortality by modifiable lifestyles were higher in the high PRS group ( > 80th percentile) compared with the low PRS group (0-80th percentile). In summary, blood pressure PRS is associated with CVD mortality in the general Japanese population. Our study implies that integrating PRS with lifestyle could contribute to identify target populations for lifestyle intervention even though improvement of discriminatory ability by PRS alone is limited.
(出版サイトへのリンク): ● Publication site (DOI): 10.1038/s41440-024-01766-9
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38961281; ● Search Scopus @ Elsevier (PMID): 38961281; ● Search Scopus @ Elsevier (DOI): 10.1038/s41440-024-01766-9

(DOI: 10.1038/s41440-024-01766-9, PubMed: 38961281) Satomi Tomida, Teruhide Koyama, Etsuko Ozaki, Naoyuki Takashima, Midori Morita, Koichi Sakaguchi, Yasuto Naoi, Yuichiro Nishida, Megumi Hara, Asahi Hishida, Takashi Tamura, Rieko Okada, Yoko Kubo, Jun Otonari, Hiroaki Ikezaki, Yohko Nakamura, Miho Kusakabe, Shiroh Tanoue, Chihaya Koriyama, N Yuriko Koyanagi, Hidemi Ito, Sadao Suzuki, Takahiro Otani, Naoko Miyagawa, Yukiko Okami, Kokichi Arisawa, Takeshi Watanabe, Kiyonori Kuriki, Kenji Wakai and Keitaro Matsuo :
Seven-plus hours of daily sedentary time and the subsequent risk of breast cancer: Japan Multi-Institutional Collaborative Cohort Study.,
Cancer Science, Vol.115, No.2, 611-622, 2024.

(要約): This study aimed to investigate the association between daily sedentary time and the risk of breast cancer (BC) in a large Japanese population. The participants were 36,023 women aged 35-69years from the Japan Multi-Institutional Collaborative Cohort Study. Cox proportional hazards analysis was used to estimate adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for BC incidence in relation to time spent sedentarily (categorical variables: <7 and 7hours/day [h/d]). Additionally, the associations of BC incidence to the joint effect of sedentary time with each component of physical activity, such as leisure-time metabolic equivalents (METs), frequency of leisure-time physical activity, and daily walking time, were examined. During 315,189 person-years of follow-up, 554 incident cases of BC were identified. When compared to participants who spent <7h/d sedentary, those who spent 7h/d sedentary have a significantly higher risk of BC (HR, 1.36; 95% CI, 1.07-1.71). The corresponding HRs among participants who spent 7h/d sedentary with more physical activity, such as 1h/d for leisure-time METs, 3days/week of leisure-time physical activity, and 1h/d of daily walking were 1.58 (95% CI, 1.11-2.25), 1.77 (95% CI, 1.20-2.61), and 1.42 (95% CI, 1.10-1.83), respectively, compared with those who spent <7h/d sedentary. This study found that spending 7h/d of sedentary time is associated with the risk of BC. Neither leisure-time physical activity nor walking had a BC-preventive effect in those with 7h/d of sedentary time.
(徳島大学機関リポジトリ): ● Metadata: 118784
(出版サイトへのリンク): ● Publication site (DOI): 10.1111/cas.16020
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38041484; ● Search Scopus @ Elsevier (PMID): 38041484; ● Search Scopus @ Elsevier (DOI): 10.1111/cas.16020

(徳島大学機関リポジトリ: 118784, DOI: 10.1111/cas.16020, PubMed: 38041484) Takahiko Nagamine, Takeshi Watanabe and Akira Toyofuku :
QTc Shortening on Electrocardiogram With Amitriptyline May Indicate No Effect on Pain Relief in Burning Mouth Syndrome.,
Clinical Neuropharmacology, 2024.

(要約): Amitriptyline provides analgesia in about half of BMS patients, but some BMS patients have worse pain with amitriptyline. Not only do changes in the QTc detect amitriptyline adverse effects with prolongation, but also, conversely, its shortening predicts amitriptyline ineffectiveness.
(徳島大学機関リポジトリ): ● Metadata: 118854
(出版サイトへのリンク): ● Publication site (DOI): 10.1097/WNF.0000000000000583
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38285063; ● Search Scopus @ Elsevier (PMID): 38285063; ● Search Scopus @ Elsevier (DOI): 10.1097/WNF.0000000000000583

(徳島大学機関リポジトリ: 118854, DOI: 10.1097/WNF.0000000000000583, PubMed: 38285063) Daisaku Nishimoto, Rie Ibusuki, Ippei Shimoshikiryo, Kenichi Shibuya, Shiroh Tanoue, Chihaya Koriyama, Toshiro Takezaki, Isao Oze, Hidemi Ito, Asahi Hishida, Takashi Tamura, Yasufumi Kato, Yudai Tamada, Yuichiro Nishida, Chisato Shimanoe, Sadao Suzuki, Takeshi Nishiyama, Etsuko Ozaki, Satomi Tomida, Kiyonori Kuriki, Naoko Miyagawa, Keiko Kondo, Kokichi Arisawa, Takeshi Watanabe, Hiroaki Ikezaki, Jun Otonari, Kenji Wakai and Keitaro Matsuo :
Association between awareness of limiting food intake and all-cause mortality: A cohort study in Japan,
Journal of Epidemiology, 2023.

(要約): Improving diets requires an awareness of the need to limit foods for which excessive consumption is a health problem. Since there are limited reports on the link between this awareness and mortality risk, we examined the association between awareness of limiting food intake (energy, fat, and sweets) and all-cause mortality in a Japanese cohort study. Participants comprised 58,772 residents (27,294 men; 31,478 women) aged 35-69 years who completed baseline surveys of the Japan Multi-Institutional Collaborative Cohort Study from 2004 to 2014. Hazard ratios (HRs) for all-cause mortality and 95% confidence intervals (CIs) were estimated by sex using a Cox proportional hazard model, with adjustment for related factors. Mediation analysis with fat intake as a mediator was also conducted. The mean follow-up period was 11 years and 2,516 people died. Estimated energy and fat intakes according to the Food Frequency Questionnaire were lower in those with awareness of limiting food intake than in those without this awareness. Women with awareness of limiting fat intake showed a significant decrease in mortality risk (HR=0.73; 95% CI, 0.55 to 0.94). Mediation analysis revealed that this association was due to the direct effect of the awareness of limiting fat intake and that the total effect was not mediated by actual fat intake. Awareness of limiting energy or sweets intake was not related to mortality risk reduction. Awareness of limiting food intake had a limited effect on reducing all-cause mortality risk.
(キーワード): awareness of limiting food intake / all-cause mortality / cohort study
(徳島大学機関リポジトリ): ● Metadata: 118729
(出版サイトへのリンク): ● Publication site (DOI): 10.2188/jea.JE20220354
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37926519; ● CiNii @ 国立情報学研究所 (CRID): 1390863329518063360; ● Summary page in Scopus @ Elsevier: 2-s2.0-85195435719

(徳島大学機関リポジトリ: 118729, DOI: 10.2188/jea.JE20220354, PubMed: 37926519, CiNii: 1390863329518063360, Elsevier: Scopus) Takashi Tamura, Kenji Wakai, Yasufumi Kato, Yudai Tamada, Yoko Kubo, Rieko Okada, Mako Nagayoshi, Asahi Hishida, Nahomi Imaeda, Chiho Goto, Hiroaki Ikezaki, Jun Otonari, Megumi Hara, Keitaro Tanaka, Yohko Nakamura, Miho Kusakabe, Rie Ibusuki, Chihaya Koriyama, Isao Oze, Hidemi Ito, Sadao Suzuki, Hiroko Nakagawa-Senda, Etsuko Ozaki, Daisuke Matsui, Kiyonori Kuriki, Keiko Kondo, Naoyuki Takashima, Takeshi Watanabe, Sakurako Kamano and Keitaro Matsuo :
Dietary carbohydrate and fat intakes and risk of mortality in the Japanese population: the Japan Multi-Institutional Collaborative Cohort Study.,
The Journal of Nutrition, Vol.153, No.8, 2352-2368, 2023.

(要約): An unfavorable association with mortality was observed for low carbohydrate intake in men and for high carbohydrate intake in women. High fat intake could be associated with a lower mortality risk in women among Japanese adults with a relatively high carbohydrate intake.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.tjnut.2023.05.027
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37271417; ● Search Scopus @ Elsevier (PMID): 37271417; ● Search Scopus @ Elsevier (DOI): 10.1016/j.tjnut.2023.05.027

(DOI: 10.1016/j.tjnut.2023.05.027, PubMed: 37271417) Takeshi Watanabe, Mette Sieg, Sigrid Juhl Lunde, Mads Persson, Pankaj Taneja, Lene Baad-Hansen, Maria Pigg and Lene Vase :
Nocebo response in dentistry: A systematic review and meta-analysis of adverse events in analgesic trials of third molar removal,
Journal of Oral Rehabilitation, Vol.50, No.4, 332-342, 2023.

(要約): The nocebo response refers to the phenomenon where non-specific factors, including negative verbal suggestion and treatment expectations, cause adverse events (AE) following a placebo treatment. Non-specific factors are also likely to influence AE occurrence following administration of active pharmacological treatments. This meta-analysis aimed to estimate the nocebo response in dentistry by assessing the AEs prevalence in placebo- and active arms of randomised controlled trials (RCTs) assessing analgesic treatment following third molar (M3) surgery. A systematic search was performed in PubMed, Embase, Scopus, Web of Science and the Cochrane Central Register of Controlled Trials. Eligible studies had to report the number of patients experiencing at least one drug-related AE (patients with AE ≥ 1) separately for the active and placebo arms. The proportion of patients with AE ≥ 1 and drug-related dropouts were pooled, and risk differences (RDs) between patients in the placebo- and active arm were calculated. In 50 independent RCTs of 47 identified articles, the pooled rates of patients with AE ≥ 1 were 22.8% in the placebo arm and 20.6% in the active arm. The pooled rates of drug-related dropout were 0.24% in the placebo arm and 0.08% in the active arm. There were no significant RDs in patients with AE ≥ 1 and drug-related dropouts. These results show that patients in the placebo arm reported AEs to the same extent as patients receiving active treatment, suggesting that most AEs in analgesic medication following M3 surgery may be attributed to the nocebo phenomenon.
(キーワード): Nocebo effect / Surgery, Oral / Analgesics [Pharmacological Action] / Pain / Long Term Adverse Effects / Molar, Third
(徳島大学機関リポジトリ): ● Metadata: 117921
(出版サイトへのリンク): ● Publication site (DOI): 10.1111/joor.13414
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36648379; ● Search Scopus @ Elsevier (PMID): 36648379; ● Search Scopus @ Elsevier (DOI): 10.1111/joor.13414

(徳島大学機関リポジトリ: 117921, DOI: 10.1111/joor.13414, PubMed: 36648379) Takeshi Watanabe, Kokichi Arisawa, Tien Van Nguyen, Masashi Ishizu, Sakurako Katsuura-Kamano, Asahi Hishida, Takashi Tamura, Yasufumi Kato, Rieko Okada, Rie Ibusuki, Chihaya Koriyama, Sadao Suzuki, Takahiro Otani, Teruhide Koyama, Satomi Tomida, Kiyonori Kuriki, Naoyuki Takashima, Naoko Miyagawa, Kenji Wakai and Keitaro Matsuo :
Coffee and Metabolic Phenotypes: A Cross-sectional Analysis of the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study,
Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, Vol.33, No.3, 620-630, 2023.

(要約): To date, the relationship between coffee consumption and metabolic phenotypes has hardly been investigated and remains controversial. Therefore, the aim of this cross-sectional study is to examine the associations between coffee consumption and metabolic phenotypes in a Japanese population. We analyzed the data of 26,363 subjects (aged 35-69 years) in the baseline survey of the Japan Multi-Institutional Collaborative Cohort Study. Coffee consumption was assessed using a questionnaire. Metabolic Syndrome (MetS) was defined according to the Joint Interim Statement Criteria of 2009, using body mass index (BMI) instead of waist circumference. Subjects stratified by the presence or absence of obesity (normal weight: BMI <25 kg/m; obesity: BMI ≥25 kg/m) were classified by the number of MetS components (metabolically healthy: no components; metabolically unhealthy: one or more components) other than BMI. In multiple logistic regression analyses adjusted for sex, age, and other potential confounders, high coffee consumption (≥3 cups/day) was associated with a lower prevalence of MetS and metabolically unhealthy phenotypes both in normal weight (OR 0.83, 95% CI 0.76-0.90) and obese subjects (OR 0.83, 95% CI 0.69-0.99). Filtered/instant coffee consumption was inversely associated with the prevalence of MetS and metabolically unhealthy phenotypes, whereas canned/bottled/packed coffee consumption was not. The present results suggest that high coffee consumption, particularly filtered/instant coffee, is inversely associated with the prevalence of metabolically unhealthy phenotypes in both normal weight and obese Japanese adults.
(キーワード): Humans / Cross-Sectional Studies / Coffee / Cohort Studies / Japan / Metabolic Syndrome / Obesity / Body Mass Index / Phenotype / Risk Factors
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.numecd.2022.12.019
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36710119; ● Search Scopus @ Elsevier (PMID): 36710119; ● Search Scopus @ Elsevier (DOI): 10.1016/j.numecd.2022.12.019

(DOI: 10.1016/j.numecd.2022.12.019, PubMed: 36710119) Takuya Sakashita, Yasuyuki Nakamura, Yoichi Sutoh, Atsushi Shimizu, Tsuyoshi Hachiya, Yayoi Otsuka-Yamasaki, Naoyuki Takashima, Aya Kadota, Katsuyuki Miura, Yoshikuni Kita, Hiroaki Ikezaki, Jun Otonari, Keitaro Tanaka, Chisato Shimanoe, Teruhide Koyama, Isao Watanabe, Sadao Suzuki, Hiroko Nakagawa-Senda, Asahi Hishida, Takashi Tamura, Yasufumi Kato, Rieko Okada, Kiyonori Kuriki, Sakurako Katsuura-Kamano, Takeshi Watanabe, Shiroh Tanoue, Chihaya Koriyama, Isao Oze, Yuriko N. Koyanagi, Yohko Nakamura, Miho Kusakabe, Masahiro Nakatochi, Yukihide Momozawa, Kenji Wakai and Keitaro Matsuo :
Comparison of the loci associated with HbA1c and blood glucose levels identified by a genome-wide association study in the Japanese population,
Diabetology International, Vol.14, No.2, 188-198, 2023.

(要約): Hemoglobin A1c (HbA1c) levels are widely employed to diagnose diabetes. However, estimates of the heritability of HbA1c and glucose levels are different. Therefore, we explored HbA1c- and blood glucose-associated loci in a non-diabetic Japanese population. We conducted a two-stage genome-wide association study (GWAS) on variants associated with HbA1c and blood glucose levels in a Japanese population. In the initial stage, data of 4911 participants of the Japan Multi-Institutional Collaborative Cohort (J-MICC) were subjected to discovery analysis. In the second stage, two datasets from the Tohoku Medical Megabank project, with 8175 and 40,519 participants, were used for the replication study. Association of the imputed variants with HbA1c and blood glucose levels was determined via linear regression analyses adjusted for age, sex, body mass index (BMI), smoking, and genetic principal components (PC1-PC10). Moreover, we performed a BMI-stratified GWAS on HbA1c levels in the J-MICC. The discovery analysis and BMI-stratified GWAS results were validated with re-analyses of normalized HbA1c levels adjusted for site in addition to the above, and blood glucose adjusted for fasting time as an additional covariate. Genetic variants associated with HbA1c levels were identified in and . None of the genetic variants associated with blood glucose levels in the discovery analysis were replicated. Association of rs2299620 in with HbA1c levels showed heterogeneity between individuals with BMI ≥ 25 kg/m and BMI < 25 kg/m. The variant rs2299620 in might affect HbA1c levels differentially based on BMI grouping in the Japanese population. The online version contains supplementary material available at 10.1007/s13340-023-00618-0.
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s13340-023-00618-0
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37090135; ● Search Scopus @ Elsevier (PMID): 37090135; ● Search Scopus @ Elsevier (DOI): 10.1007/s13340-023-00618-0

(DOI: 10.1007/s13340-023-00618-0, PubMed: 37090135) Rintaro Sogawa, Chisato Shimanoe, Keitaro Tanaka, Megumi Hara, Yuichiro Nishida, Takuma Furukawa, Mako Nagayoshi, Asahi Hishida, Yoko Kubo, Yasufumi Kato, Isao Oze, Hidemi Ito, Yohko Nakamura, Miho Kusakabe, Shiroh Tanoue, Chihaya Koriyama, Sadao Suzuki, Takahiro Otani, Daisuke Matsui, Isao Watanabe, Kiyonori Kuriki, Naoyuki Takashima, Aya Kadota, Takeshi Watanabe, Kokichi Arisawa, Hiroaki Ikezaki, Jun Otonari, Kenji Wakai and Keitaro Matsuo :
Sex- and age-specific all-cause mortality in insomnia with hypnotics: Findings from Japan multi-institutional Collaborative Cohort Study.,
Sleep Medicine, Vol.100, 410-418, 2022.

(要約): During the follow-up (mean, 8.4 ± 2.5 years), 1,492 mortalities were recorded, and the prevalence of taking hypnotics was 4.2%. Hypnotic use was associated with significantly greater risk of all-cause mortality, even after adjustment for the covariates (HR, 1.32; 95% CI, 1.07-1.63). The association between hypnotic use and all-cause mortality was robust in males (HR, 1.51; 95% CI, 1.15-1.96), and participants aged <60 years (HR, 1.75; 95% CI, 1.21-2.54).
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.sleep.2022.09.020
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36240602; ● Search Scopus @ Elsevier (PMID): 36240602; ● Search Scopus @ Elsevier (DOI): 10.1016/j.sleep.2022.09.020

(DOI: 10.1016/j.sleep.2022.09.020, PubMed: 36240602) 井上徹, 渡邊毅, 石川賀代 :
介護施設入所者におけるGeriatric Nutritional Risk Index，血清アルブミン値，Body Mass Index の評価と関連する因子について,
四国医学雑誌, Vol.78, No.3, 4, 95-102, 2022年.

(要約): Geriatric Nutritional Risk Index(GNRI)is a nutritional risk assessment tool for the elderly calculated from Body Mass Index(BMI)and serum albumin level. GNRI score has been known to be correlated with Mini nutritional assessment score and be calculated easily, therefore this index has been utilized as a useful tool to evaluate nutritional status of the elderly staying in nursing homes. The aim of this study is to investigate the relationship between GNRI and indicators of geriatric health status such as activities of daily living(ADL), cognitive functions, oral functions and number of regular drugs. This cross-sectional study was conducted with the data of 207(40 males, 167 females)nursing home residents examined in 2019 - 2020. We evaluated GNRI, serum albumin level, BMI, ADL, HDS-R, oral functions, number of regular drugs, and CBC(complete blood count). Multiple regression analysis was performed by using the obtained data. As a result, GNRI was associated with ADL and HDS-R. BMI and serum albumin, which are components of GNRI, were associated with ADL and HDS-R, respectively. This study suggests that that GNRI is associated with mobility and cognitive functions. Therefore, GNRI could be a useful assessment tool for overall health status of the elderly, not just their nutritional status.
(キーワード): 介護施設 / 栄養 / 日常生活動作 / 認知機能
(徳島大学機関リポジトリ): ● Metadata: 117789
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1050294407571218432

(徳島大学機関リポジトリ: 117789, CiNii: 1050294407571218432) Takeshi Watanabe, Mette Sieg, Sigrid Juhl Lunde, Pankaj Taneja, Lene Baad-Hansen, Maria Pigg and Lene Vase :
What is the nocebo effect and does it apply to dentistry? A narrative review.,
Journal of Oral Rehabilitation, 2022.

(要約): Evidence for the nocebo effect, a phenomenon characterised by suboptimal treatment efficacy, worsening of symptoms, or the occurrence of adverse events caused by an individual's negative treatment expectations, is growing across a multitude of medical fields. Within dentistry, little attention has been paid to patients' negative expectations, despite a number of studies supporting the influence of related factors, such as dental fear and anxiety, on the severity of peri- and post-operative dental pain. Only recently, a small number of commentaries and letters have emerged, urging dentists to recognise the possible existence of nocebo effects in dentistry and its implications for patient care. The present review summarises essential evidence of the nocebo phenomenon especially in relation to pain and drug administration. Subsequently, an overview of the current evidence of the nocebo phenomenon in the dental field is presented. Finally, based on the general knowledge of the nocebo effect, the review indicates fruitful arrays of research into the nocebo effect in dentistry.
(徳島大学機関リポジトリ): ● Metadata: 116847
(出版サイトへのリンク): ● Publication site (DOI): 10.1111/joor.13306
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35043415; ● Search Scopus @ Elsevier (PMID): 35043415; ● Search Scopus @ Elsevier (DOI): 10.1111/joor.13306

(徳島大学機関リポジトリ: 116847, DOI: 10.1111/joor.13306, PubMed: 35043415) Yojiro Umezaki, Motoko Watanabe, Yukiko Shinohara, Shiori Sugawara, Kaoru Kawasaki, Trang T.H. Tu, Takeshi Watanabe, Takayuki Suga, Anna Miura, Miho Takenoshita, Yusuke Sato, Ichiro Minami, Jun Oyama, Akira Toriihara, Tatsuya Yoshikawa, Toru Naito, Haruhiko Motomura and Akira Toyofuku :
Comparison of Cerebral Blood Flow Patterns in Patients with Phantom Bite Syndrome with Their Corresponding Clinical Features.,
Neuropsychiatric Disease and Treatment, Vol.16, 2277-2284, 2020.

(要約): Patients with PBS showed blood flow imbalance in the thalamus and parietal region corresponding to symptom laterality. There are two types of symmetrical and asymmetrical rCBF patterns in the pathophysiology of PBS despite similar clinical manifestations.
(徳島大学機関リポジトリ): ● Metadata: 118036
(出版サイトへのリンク): ● Publication site (DOI): 10.2147/NDT.S262892
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33116526; ● Search Scopus @ Elsevier (PMID): 33116526; ● Search Scopus @ Elsevier (DOI): 10.2147/NDT.S262892

(徳島大学機関リポジトリ: 118036, DOI: 10.2147/NDT.S262892, PubMed: 33116526) Kaoru Kawasaki, Shiori Sugawara, Kazuya Watanabe, Chaoli Hong, Trang T.H. Tu, Takeshi Watanabe, Junichiro Sakamoto, Norio Yoshino, Takayuki Suga, Lou Mikuzuki, Miho Takenoshita, Satoshi Takada, Tohru Kurabayashi and Akira Toyofuku :
Differences in the Clinical Characteristics of Persistent Idiopathic Facial Pain (Atypical Odontalgia) Patients with or Without Neurovascular Compression of the Trigeminal Nerve.,
Pain Medicine, Vol.21, No.4, 814-821, 2020.

(要約): These results suggest that PIFP patients can be divided into two groups: one consistent with a neuropathic pain phenotype when NVC is present and a functional somatic symptom phenotype when presenting without NVC. Our findings may enable a more precise understanding of pathophysiology of PIFP and lead to better treatment strategies.
(キーワード): Anxiety Disorders / Bipolar Disorder / Case-Control Studies / Catastrophization / Chest Pain / Depressive Disorder / Dyspnea / Facial Neuralgia / Female / Headache / Humans / Magnetic Resonance Imaging / Male / Mental Disorders / Middle Aged / Nerve Compression Syndromes / Retrospective Studies / Somatoform Disorders / Toothache / Trigeminal Nerve
(徳島大学機関リポジトリ): ● Metadata: 116306
(出版サイトへのリンク): ● Publication site (DOI): 10.1093/pm/pnz300
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32040150; ● Search Scopus @ Elsevier (PMID): 32040150; ● Search Scopus @ Elsevier (DOI): 10.1093/pm/pnz300

(徳島大学機関リポジトリ: 116306, DOI: 10.1093/pm/pnz300, PubMed: 32040150) 渡邊毅, 上甲カユ, 中村明美, 櫻庭佑佳, 青田宥馬, 美久月瑠宇, 三浦和仁, 須賀隆行, 篠原優貴子, 竹之下美穂, 渋田敏詩, 高橋晋, 石河朝子, 堤祐一郎, 豊福明 :
博慈会優秀臨床レポート賞精神科入院患者の口腔内環境および抗精神病薬副作用 : 精神疾患を有する患者の歯科治療を安全に行うために,
未病と抗老化 : Pre symptomatic medicine and anti aging : 財団法人博慈会老人病研究所紀要 / 博慈会老人病研究所編, Vol.28, 22-26, 2019年.

(徳島大学機関リポジトリ): ● Metadata: 118109
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1050295801993341440

(徳島大学機関リポジトリ: 118109, CiNii: 1050295801993341440) Yukiko Shinohara, Yojiro Umezaki, Ichiro Minami, Motoko Watanabe, Anna Miura, Lou Mikutsuki, Kaoru Kawasaki, Shiori Sugawara, Trang T.H. Tu, Takayuki Suga, Takeshi Watanabe, Tatsuya Yoshikawa, Miho Takenoshita, Haruhiko Motomura and Akira Toyofuku :
Comorbid depressive disorders and left-side dominant occlusal discomfort in patients with phantom bite syndrome.,
Journal of Oral Rehabilitation, Vol.47, No.1, 36-41, 2019.

(要約): Approximately half of the 199 enrolled patients had bilateral occlusal discomfort. In the others, the side with occlusal discomfort generally tended to be the one that had received dental treatment. There was no significant relationship between the side chiefly affected by occlusal discomfort and whether dental treatment had been received; however, the affected side differed depending on whether the patient had comorbid psychiatric disorders (P = .041).
(キーワード): Dental Occlusion / Depressive Disorder / Humans / Retrospective Studies / Syndrome
(徳島大学機関リポジトリ): ● Metadata: 116307
(出版サイトへのリンク): ● Publication site (DOI): 10.1111/joor.12872
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31398263; ● Search Scopus @ Elsevier (PMID): 31398263; ● Search Scopus @ Elsevier (DOI): 10.1111/joor.12872

(徳島大学機関リポジトリ: 116307, DOI: 10.1111/joor.12872, PubMed: 31398263) 渡邊毅, 美久月瑠宇, 三浦和仁, 須賀隆行, 長嶺敬彦, 豊福明 :
プラセボ効果と歯科治療-Medically Unexplained Oral Symptoms (MUOS) を生じさせないために,
最新精神医学, Vol.24, No.3, 235-240, 2019年.

(徳島大学機関リポジトリ): ● Metadata: 118035
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1050580372639831808

(徳島大学機関リポジトリ: 118035, CiNii: 1050580372639831808) Trang T.H. Tu, Anna Miura, Yukiko Shinohara, Lou Mikuzuki, Kaoru Kawasaki, Shiori Sugawara, Takayuki Suga, Takeshi Watanabe, Yuma Aota, Yojiro Umezaki, Miho Takenoshita and Akira Toyofuku :
Pharmacotherapeutic outcomes in atypical odontalgia: determinants of pain relief.,
Journal of Pain Research, Vol.12, 831-839, 2019.

(要約): Our findings confirm the efficacy of tricyclic antidepressants (TCAs) as a treatment for AO and indicate that other medications, especially aripiprazole used in combination with a TCA, may be useful. A considerable number of patients, especially women, those with lower levels of depression at baseline, and those who responded to 4 weeks of treatment, achieved pain relief.
(徳島大学機関リポジトリ): ● Metadata: 116318
(出版サイトへのリンク): ● Publication site (DOI): 10.2147/JPR.S188362
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30881094; ● Search Scopus @ Elsevier (PMID): 30881094; ● Search Scopus @ Elsevier (DOI): 10.2147/JPR.S188362

(徳島大学機関リポジトリ: 116318, DOI: 10.2147/JPR.S188362, PubMed: 30881094) Takeshi Watanabe, Takahiko Nagamine, Lou Mikuzuki, Yuma Aota, Takayuki Suga, Trang T.H. Tu, Kaoru Kawasaki, Yukiko Shinohara, Miho Takenoshita and Akira Toyofuku :
Changes in Corrected QT Interval May Be Associated with Clinical Responses in Burning Mouth Syndrome.,
International Medical Journal, Vol.26, No.1, 13-14, 2019.

(徳島大学機関リポジトリ): ● Metadata: 117855
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1010003825519573637

(徳島大学機関リポジトリ: 117855, CiNii: 1010003825519573637) Trang T.H. Tu, Miho Takenoshita, Hirofumi Matsuoka, Takeshi Watanabe, Takayuki Suga, Yuma Aota, Yoshihiro Abiko and Akira Toyofuku :
Current management strategies for the pain of elderly patients with burning mouth syndrome: a critical review.,
BioPsychoSocial Medicine, Vol.13, 2019.

(要約): Burning Mouth Syndrome (BMS), a chronic intraoral burning sensation or dysesthesia without clinically evident causes, is one of the most common medically unexplained oral symptoms/syndromes. Even though the clinical features of BMS have been astonishingly common and consistent throughout the world for hundreds of years, BMS remains an enigma and has evolved to more intractable condition. In fact, there is a large and growing number of elderly BMS patients for whom the disease is accompanied by systemic diseases, in addition to aging physical change, which makes the diagnosis and treatment of BMS more difficult. Because the biggest barrier preventing us from finding the core pathophysiology and best therapy for BMS seems to be its heterogeneity, this syndrome remains challenging for clinicians. In this review, we discuss currently hopeful management strategies, including central neuromodulators (Tricyclic Antidepressants - TCAs, Serotonin, and Norepinephrine Reuptake Inhibitors - SNRIs, Selective Serotonin Reuptake Inhibitors - SSRIs, Clonazepam) and solutions for applying non-pharmacology approaches. Moreover, we also emphasize the important role of patient education and anxiety management to improve the patients' quality of life. A combination of optimized medication with a short-term supportive psychotherapeutic approach might be a useful solution.
(徳島大学機関リポジトリ): ● Metadata: 116308
(出版サイトへのリンク): ● Publication site (DOI): 10.1186/s13030-019-0142-7
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30733824; ● Search Scopus @ Elsevier (PMID): 30733824; ● Search Scopus @ Elsevier (DOI): 10.1186/s13030-019-0142-7

(徳島大学機関リポジトリ: 116308, DOI: 10.1186/s13030-019-0142-7, PubMed: 30733824) Takeshi Watanabe, Akinori Kimura and Hidehito Kuroyanagi :
Alternative Splicing Regulator RBM20 and Cardiomyopathy.,
Frontiers in Molecular Biosciences, Vol.5, 2018.

(要約): pre-mRNA splicing, raising RBM20 as a potential therapeutic target.
(徳島大学機関リポジトリ): ● Metadata: 116317
(出版サイトへのリンク): ● Publication site (DOI): 10.3389/fmolb.2018.00105
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30547036; ● Search Scopus @ Elsevier (PMID): 30547036; ● Search Scopus @ Elsevier (DOI): 10.3389/fmolb.2018.00105

(徳島大学機関リポジトリ: 116317, DOI: 10.3389/fmolb.2018.00105, PubMed: 30547036) Yojiro Umezaki, Anna Miura, Yukiko Shinohara, Lou Mikuzuki, Shiori Sugawara, Kaoru Kawasaki, Trang T.H. Tu, Takeshi Watanabe, Takayuki Suga, Motoko Watanabe, Miho Takenoshita, Tatsuya Yoshikawa, Akihito Uezato, Toru Nishikawa, Ken Hoshiko, Toru Naito, Haruhiko Motomura and Akira Toyofuku :
Clinical characteristics and course of oral somatic delusions: a retrospective chart review of 606 cases in 5 years.,
Neuropsychiatric Disease and Treatment, Vol.14, 2057-2065, 2018.

(要約): Patients with oral cenesthopathy in our clinic were predominantly elderly female patients. Dental treatment in the acute phase of depression might be a risk factor for oral cenesthopathy. Therefore, comprehending the situation of psychiatric disorder and obtaining adequate informed consent might be required to prevent the trouble concerning oral cenesthopathy.
(徳島大学機関リポジトリ): ● Metadata: 116310
(出版サイトへのリンク): ● Publication site (DOI): 10.2147/NDT.S167527
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30147319; ● Search Scopus @ Elsevier (PMID): 30147319; ● Search Scopus @ Elsevier (DOI): 10.2147/NDT.S167527

(徳島大学機関リポジトリ: 116310, DOI: 10.2147/NDT.S167527, PubMed: 30147319) Takeshi Watanabe, Takahiko Nagamine, Lou Mikuzuki, Yuma Aota, Takayuki Suga, Trang T.H. Tu, Miho Takenoshita and Akira Toyofuku :
An increase in corrected QT interval may indicate a good clinical response to amitriptyline in female patients with burning mouth syndrome,
Neurology and Neurobiology, Vol.1, No.1, 1-3, 2018.

(要約): Burning mouth syndrome (BMS) is characterized by a burning sensation of the oral mucosa in the absence of underlying causes. BMS patients can pose a therapeutic challenge to clinicians. Amitriptyline has been a first-line treatment for BMS and is known to prolong corrected QT interval (QTc) in a dose dependent manner. However, little is known about the QTc lengthening effect of amitriptyline at analgesic dosages. The objective of this study was to evaluate changes in QTc in female BMS patients treated with amitriptyline. We conducted a single-center retrospective observational study and evaluated 40 female BMS patients. The QTc interval did not show statistically significant increase with amitriptyline (p=0.1502). However, the change in QTc of amitriptyline-responders was significantly longer than that of non-responders (p=0.0142). The change in QTc may be a non-invasive maker of clinical responses to amitriptyline in female BMS patients.
(キーワード): Amitriptyline / autonomic nerve function / burning mouth syndrome / QTc
(徳島大学機関リポジトリ): ● Metadata: 117856
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1050294562444024320

(徳島大学機関リポジトリ: 117856, CiNii: 1050294562444024320) 渡邊毅, 長嶺敬彦, 美久月瑠宇, 川崎カオル, 須賀隆行, 竹之下美穂, 豊福明 :
歯科領域における慢性疼痛に対する抗うつ薬の効果と副作用,
最新精神医学, Vol.23, No.4, 357-362, 2018年.

(キーワード): chronic oral pain / burning mouth syndrome (BMS) / atypical odontalgia (AO) / antidepressant / adverse effect
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1521136280313388928

(CiNii: 1521136280313388928) Kaoru Kawasaki, Takahiko Nagamine, Takeshi Watanabe, Takayuki Suga, Trang T.H. Tu, Shiori Sugawara, Lou Mikuzuki, Anna Miura, Yukiko Shinohara, Tatsuya Yoshikawa, Miho Takenoshita and Akira Toyofuku :
An increase in salivary flow with amitriptyline may indicate treatment resistance in burning mouth syndrome.,
Asia-Pacific Psychiatry, Vol.10, No.3, 2018.

(キーワード): Adult / Aged / Amitriptyline / Analgesics, Non-Narcotic / Burning Mouth Syndrome / Female / Humans / Male / Middle Aged / Sialorrhea
(出版サイトへのリンク): ● Publication site (DOI): 10.1111/appy.12315
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29575764; ● Search Scopus @ Elsevier (PMID): 29575764; ● Search Scopus @ Elsevier (DOI): 10.1111/appy.12315

(DOI: 10.1111/appy.12315, PubMed: 29575764) Trang T.H. Tu, Anna Miura, Yukiko Shinohara, Lou Mikuzuki, Kaoru Kawasaki, Shiori Sugawara, Takayuki Suga, Takeshi Watanabe, Motoko Watanabe, Yojiro Umezaki, Tatsuya Yoshikawa, Haruhiko Motomura, Miho Takenoshita and Akira Toyofuku :
Evaluating Burning Mouth Syndrome as a Comorbidity of Atypical Odontalgia: The Impact on Pain Experiences.,
Pain Practice, Vol.18, No.5, 580-586, 2017.

(要約): AO-BMS patients have different epidemiological characteristics, sleep quality, and pain experiences compared to AO-only patients. The presence of psychiatric comorbidities in both groups may exacerbate sleep quality. We suggest that BMS as a comorbid oral disorder in AO patients contributes to a more intensively painful experience.
(キーワード): Aged / Burning Mouth Syndrome / Comorbidity / Depression / Female / Humans / Male / Middle Aged / Prevalence / Sleep Wake Disorders / Toothache
(徳島大学機関リポジトリ): ● Metadata: 116313
(出版サイトへのリンク): ● Publication site (DOI): 10.1111/papr.12647
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28972293; ● Search Scopus @ Elsevier (PMID): 28972293; ● Search Scopus @ Elsevier (DOI): 10.1111/papr.12647

(徳島大学機関リポジトリ: 116313, DOI: 10.1111/papr.12647, PubMed: 28972293) Anna Miura, Trang T.H. Tu, Yukiko Shinohara, Lou Mikuzuki, Kaoru Kawasaki, Shiori Sugawara, Takayuki Suga, Takeshi Watanabe, Motoko Watanabe, Yojiro Umezaki, Tatsuya Yoshikawa, Haruhiko Motomura, Miho Takenoshita, Hidefumi Maeda and Akira Toyofuku :
Psychiatric comorbidities in patients with Atypical Odontalgia.,
Journal of Psychosomatic Research, Vol.104, 35-40, 2017.

(要約): About half of AO patients had comorbid psychiatric disorders. Dental procedures are not necessarily causative factors of AO. In AO patients with comorbid psychiatric disorders, pain might have a larger emotional component than a sensory one. VAS, SDS, and SF-MPQ scores might aid in the noticing of underlying comorbid psychiatric disorders in AO patients.
(キーワード): Adolescent / Adult / Aged / Aged, 80 and over / Comorbidity / Female / Humans / Male / Mental Disorders / Middle Aged / Pain Measurement / Retrospective Studies / Surveys and Questionnaires / Toothache / Young Adult
(徳島大学機関リポジトリ): ● Metadata: 116312
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jpsychores.2017.11.001
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29275783; ● Search Scopus @ Elsevier (PMID): 29275783; ● Search Scopus @ Elsevier (DOI): 10.1016/j.jpsychores.2017.11.001

(徳島大学機関リポジトリ: 116312, DOI: 10.1016/j.jpsychores.2017.11.001, PubMed: 29275783) Takeshi Watanabe, Shiori Sekine, Isao Naguro, Yusuke Sekine and Hidenori Ichijo :
Apoptosis Signal-regulating Kinase 1 (ASK1)-p38 Pathway-dependent Cytoplasmic Translocation of the Orphan Nuclear Receptor NR4A2 Is Required for Oxidative Stress-induced Necrosis.,
The Journal of Biological Chemistry, Vol.290, No.17, 10791-10803, 2015.

(要約): p38 mitogen-activated protein kinases (MAPKs) play important roles in various cellular stress responses, including cell death, which is roughly categorized into apoptosis and necrosis. Although p38 signaling has been extensively studied, the molecular mechanisms of p38-mediated cell death are unclear. ASK1 is a stress-responsive MAP3K that acts as an upstream kinase of p38 and is activated by various stresses, such as oxidative stress. Here, we show that NR4A2, a member of the NR4A nuclear receptor family, acts as a necrosis promoter downstream of ASK1-p38 pathway during oxidative stress. Although NR4A2 is well known as a nucleus-localized transcription factor, we found that it is translocated into the cytosol after phosphorylation by p38. Because the phosphorylation site mutants of NR4A2 cannot rescue the cell death-promoting activity, ASK1-p38 pathway-dependent phosphorylation and subsequent cytoplasmic translocation of NR4A2 may be required for oxidative stress-induced cell death. In addition, NR4A2-mediated cell death does not depend on caspases and receptor-interacting protein 1 (RIP1)-RIP3 complex, suggesting that NR4A2 promotes an RIP kinase-independent necrotic type of cell death. Our findings may enable a more precise understanding of molecular mechanisms that regulate oxidative stress-induced and p38-mediated necrosis.
(キーワード): Animals / Biological Transport, Active / Cell Line / Cytoplasm / HeLa Cells / Humans / Hydrogen Peroxide / MAP Kinase Kinase Kinase 5 / MAP Kinase Signaling System / Mice / Necrosis / Nuclear Receptor Subfamily 4, Group A, Member 2 / Oxidative Stress / Phosphorylation / RNA, Small Interfering / p38 Mitogen-Activated Protein Kinases
(徳島大学機関リポジトリ): ● Metadata: 116314
(出版サイトへのリンク): ● Publication site (DOI): 10.1074/jbc.M114.623280
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25752609; ● Search Scopus @ Elsevier (PMID): 25752609; ● Search Scopus @ Elsevier (DOI): 10.1074/jbc.M114.623280

(徳島大学機関リポジトリ: 116314, DOI: 10.1074/jbc.M114.623280, PubMed: 25752609) Yusuke Sekine, Ryo Hatanaka, Takeshi Watanabe, Naoki Sono, Shun-ichiro Iemura, Tohru Natsume, Erina Kuranaga, Masayuki Miura, Kohsuke Takeda and Hidenori Ichijo :
The Kelch repeat protein KLHDC10 regulates oxidative stress-induced ASK1 activation by suppressing PP5.,
Molecular Cell, Vol.48, No.5, 692-704, 2012.

(要約): Reactive oxygen species (ROS)-induced activation of Apoptosis signal-regulating kinase 1 (ASK1) plays crucial roles in oxidative stress-mediated cell death through the activation of the JNK and p38 MAPK pathways. However, the regulatory mechanism of ASK1 in the oxidative stress response remains to be elucidated. Here, we identified the kelch repeat protein, Slim, as an activator of ASK1 through a Drosophila misexpression screen. We also performed a proteomics screen and revealed that Kelch domain containing 10 (KLHDC10), a mammalian ortholog of Slim, interacted with Protein phosphatase 5 (PP5), which has been shown to inactivate ASK1 in response to ROS. KLHDC10 bound to the phosphatase domain of PP5 and suppressed its phosphatase activity. Moreover, KLHDC10 was required for H(2)O(2)-induced sustained activation of ASK1 and cell death in Neuro2A cells. These findings suggest that Slim/KLHDC10 is an activator of ASK1, contributing to oxidative stress-induced cell death through the suppression of PP5.
(キーワード): Animals / Carrier Proteins / Cell Death / Cell Line, Tumor / Cloning, Molecular / Drosophila Proteins / Drosophila melanogaster / Enzyme Activation / Gene Expression Regulation / HEK293 Cells / Humans / Hydrogen Peroxide / MAP Kinase Kinase Kinase 5 / MAP Kinase Kinase Kinases / Melanins / Mice / Mutagenesis, Site-Directed / Nuclear Proteins / Oxidants / Oxidative Stress / Phosphoprotein Phosphatases / Point Mutation / Protein Interaction Domains and Motifs / Protein Interaction Mapping / Proteomics / RNA Interference / Signal Transduction / Time Factors / Transfection / Ubiquitin-Protein Ligases / p38 Mitogen-Activated Protein Kinases
(徳島大学機関リポジトリ): ● Metadata: 116315
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.molcel.2012.09.018
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23102700; ● Search Scopus @ Elsevier (PMID): 23102700; ● Search Scopus @ Elsevier (DOI): 10.1016/j.molcel.2012.09.018

(徳島大学機関リポジトリ: 116315, DOI: 10.1016/j.molcel.2012.09.018, PubMed: 23102700) Yusuke Sekine, Shuichi Takagahara, Ryo Hatanaka, Takeshi Watanabe, Haruka Oguchi, Takuya Noguchi, Isao Naguro, Kazuto Kobayashi, Makoto Tsunoda, Takashi Funatsu, Hiroshi Nomura, Takeshi Toyoda, Norio Matsuki, Erina Kuranaga, Masayuki Miura, Kohsuke Takeda and Hidenori Ichijo :
p38 MAPKs regulate the expression of genes in the dopamine synthesis pathway through phosphorylation of NR4A nuclear receptors.,
Journal of Cell Science, Vol.124, No.Pt 17, 3006-3016, 2011.

(要約): In Drosophila, the melanization reaction is an important defense mechanism against injury and invasion of microorganisms. Drosophila tyrosine hydroxylase (TH, also known as Pale) and dopa decarboxylase (Ddc), key enzymes in the dopamine synthesis pathway, underlie the melanin synthesis by providing the melanin precursors dopa and dopamine, respectively. It has been shown that expression of Drosophila TH and Ddc is induced in various physiological and pathological conditions, including bacterial challenge; however, the mechanism involved has not been fully elucidated. Here, we show that ectopic activation of p38 MAPK induces TH and Ddc expression, leading to upregulation of melanization in the Drosophila cuticle. This p38-dependent melanization was attenuated by knockdown of TH and Ddc, as well as by that of Drosophila HR38, a member of the NR4A family of nuclear receptors. In mammalian cells, p38 phosphorylated mammalian NR4As and Drosophila HR38 and potentiated these NR4As to transactivate a promoter containing NR4A-binding elements, with this transactivation being, at least in part, dependent on the phosphorylation. This suggests an evolutionarily conserved role for p38 MAPKs in the regulation of NR4As. Thus, p38-regulated gene induction through NR4As appears to function in the dopamine synthesis pathway and may be involved in immune and stress responses.
(キーワード): Amino Acid Sequence / Animals / Dopa Decarboxylase / Dopamine / Drosophila / Female / Gene Expression Regulation / Male / Molecular Sequence Data / Phosphorylation / Receptors, Cytoplasmic and Nuclear / Sequence Alignment / Transfection / p38 Mitogen-Activated Protein Kinases
(徳島大学機関リポジトリ): ● Metadata: 116316
(出版サイトへのリンク): ● Publication site (DOI): 10.1242/jcs.085902
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21878507; ● Search Scopus @ Elsevier (PMID): 21878507; ● Search Scopus @ Elsevier (DOI): 10.1242/jcs.085902

(徳島大学機関リポジトリ: 116316, DOI: 10.1242/jcs.085902, PubMed: 21878507)

MISC

渡邊毅, 細川育子, 工藤景子, 新嶋祐一朗 :
歯科治療の不快感を最小化する,
メディカル・サイエンス・ダイジェスト, Vol.58, No.8, 34-36, 2024年.

(キーワード): Nocebo effect / Dentistry / Pain / Negative expectation / バーチャル·リアリティ (virtual reality)

渡邊毅 :
素顔のニューロサイエンティスト Lene Vase,
Clinical Neuroscience, Vol.41, 1379, 2023年. Takeshi Watanabe, Mette Sieg, Sigrid Juhl Lunde, Pankaj Taneja, Lene Baad-Hansen, Maria Pigg and Lene Vase :
Hvad er noceboeffekten, og spiller den en rolle i odontologien? En narrativ oversigt,
tandlaegebladet.dk, 2023.

(徳島大学機関リポジトリ): ● Metadata: 118087

(徳島大学機関リポジトリ: 118087) 渡邊毅 :
令和3年度研究者ラウンジ: ノセボ効果とは何か?歯科領域への応用は可能か?,
未病と抗老化, Vol.31, 101, 2022年.

(徳島大学機関リポジトリ): ● Metadata: 117836
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1050576282619785088

(徳島大学機関リポジトリ: 117836, CiNii: 1050576282619785088) 渡邊毅 :
コロナ禍でのデンマーク留学,
上原記念生命科学財団海外留学だより, 2021年.

(徳島大学機関リポジトリ): ● Metadata: 118029

(徳島大学機関リポジトリ: 118029) 渡邊毅 :
北欧・バルト三国で活躍する日本人研究者の紹介②,
JSPS Stockholm News Letter, Vol.67, 9-12, 2021年.

(徳島大学機関リポジトリ): ● Metadata: 118055

(徳島大学機関リポジトリ: 118055) Takeshi Watanabe, Kaoru Kawasaki, Trang T.H. Tu, Akira Toyofuku and Takahiko Nagamine :
Amitriptyline increases salivary flow in treatment-resistant burning mouth syndrome: What is the underlying mechanism?,
Atlas of Science, 2018.

(徳島大学機関リポジトリ): ● Metadata: 117854
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1050576502663609856

(徳島大学機関リポジトリ: 117854, CiNii: 1050576502663609856) Takahiko Nagamine and Takeshi Watanabe :
The catastrophic perception of pain in burning mouth syndrome may be associated with sympathetic tone as indicated by the QTc interval,
Innovations in Clinical Neuroscience, Vol.21, No.1-3, 8-9, 2024.

(キーワード): burning mouth syndrome / large-scale brain network / maladaptive cognition / pain catarstrophiczing scale / QTc interval
(徳島大学機関リポジトリ): ● Metadata: 118645
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38495607; ● CiNii @ 国立情報学研究所 (CRID): 1050863550660812032; ● Summary page in Scopus @ Elsevier: 2-s2.0-85188258086

(徳島大学機関リポジトリ: 118645, PubMed: 38495607, CiNii: 1050863550660812032, Elsevier: Scopus) Takahiko Nagamine and Takeshi Watanabe :
QTc interval and sympathetic tone in burning mouth syndrome,
Brain & Heart, Vol.2, No.1, 2016, 2023.

(徳島大学機関リポジトリ): ● Metadata: 118845
(出版サイトへのリンク): ● Publication site (DOI): 10.36922/bh.2016
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.36922/bh.2016

(徳島大学機関リポジトリ: 118845, DOI: 10.36922/bh.2016) Takayuki Suga, Takeshi Watanabe, Yuma Aota, Takahiko Nagamine and Akira Toyofuku :
Burning mouth syndrome: The challenge of an aging population.,
Geriatrics & Gerontology International, Vol.18, No.12, 1649-1650, 2018.

(キーワード): Age Factors / Aged / Burning Mouth Syndrome / Female / Humans / Japan / Male / Prevalence / Quality of Life
(徳島大学機関リポジトリ): ● Metadata: 116309
(出版サイトへのリンク): ● Publication site (DOI): 10.1111/ggi.13548
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30548780; ● Search Scopus @ Elsevier (PMID): 30548780; ● Search Scopus @ Elsevier (DOI): 10.1111/ggi.13548

(徳島大学機関リポジトリ: 116309, DOI: 10.1111/ggi.13548, PubMed: 30548780) Takeshi Watanabe, Kaoru Kawasaki, Trang T.H. Tu, Takayuki Suga, Shiori Sugawara, Lou Mikuzuki, Anna Miura, Yukiko Shinohara, Tatsuya Yoshikawa, Miho Takenoshita, Akira Toyofuku and Takahiko Nagamine :
The QTc shortening with amitriptyline may indicate treatment resistance in chronic nonorganic orofacial pain,
Clinical Neuropsychopharmacology and Therapeutics, Vol.9, No.0, 12-14, 2018.

(徳島大学機関リポジトリ): ● Metadata: 118034
(出版サイトへのリンク): ● Publication site (DOI): 10.5234/cnpt.9.12
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390282680315095936; ● Search Scopus @ Elsevier (DOI): 10.5234/cnpt.9.12

(徳島大学機関リポジトリ: 118034, DOI: 10.5234/cnpt.9.12, CiNii: 1390282680315095936)

総説・解説

渡邊毅, 一條秀憲, 西頭英起 :
神経変性疾患と小胞体ストレス,
Bio Clinica, Vol.26, No.7, 612-616, 2011年7月.

講演・発表

Takeshi Watanabe, Taichi Unohara and Takahiko Nagamine :
Nociplastic Pain in Dentistry: A Literature Review,
IASP 2024 World Congress on Pain, Amsterdam, Netherlands, Aug. 2024. Takeshi Watanabe :
Placebo/Nocebo research in the post-GWAS era,
4th International Conference of the Society for Interdisciplinary Placebo Studies (SIPS), Duisburg, Germany, May 2023. Nguyen Van Tien, Kokichi Arisawa, Sakurako Kamano, Takeshi Watanabe and Masashi Ishizu :
Association of metabolic syndrome and metabolically unhealthy obesity with cancer mortality,
Asia Pacific Conference 2022, Beppu, Dec. 2022. Takeshi Watanabe, Mette Sieg, Sigrid Juhl Lunde, Mads Persson, Pankaj Taneja, Lene Baad-Hansen, Maria Pigg and Lene Vase :
Nocebo response in Dentistry: A systematic review and meta-analysis,
IASP 2022 World Congress on Pain, Toronto, Canada, 19-23, September, Toronto, Sep. 2022.

(キーワード): nocebo response / analgesics / dentistry / 3rd molar / randomised controlled trial

Takeshi Watanabe, Mette Sieg, Sigrid Juhl Lunde, Pankaj Taneja, Lene Baad-Hansen and Lene Vase :
Adverse events in placebo groups of clinical trials of analgesics for post-operative dental pain: A systematic review and meta-analysis,
3rd International conference of Society for Interdisciplinary Placebo Studies (SIPS), the the University of Maryland, Baltimore U.S.A., May 2021. 渡邊毅 :
コーヒー摂取と代謝表現型:J-MICC研究のベースラインデータを用いた横断研究,
令和5年度コホート・生体試料支援プラットフォーム若手支援研究成果発表会, 2024年2月. 釜野桜子, 石津将, 渡邊毅 :
出生体重と日本人中高年の不安特性との関連:J-MICC Study 徳島地区調査,
第34階日本疫学会学術総会, 2024年2月. 渡邊毅 :
コーヒー摂取と代謝表現型:J-MICC研究のベースラインデータを用いた横断研究,
2023 年度科学研究費補助⾦「コホート・⽣体試料⽀援プラットフォーム」⽀援に係る会議⽇本多施設共同コーホート(J-MICC)研究2023 年度第2回全体会議, 2023年12月. 釜野桜子, 有澤孝吉, 石津将, 渡邊毅, TIEN VAN NGUYEN :
大豆製品およびイソフラボン摂取量と糖尿病罹患との関連:J-MICC Study,
第33回日本疫学会学術総会, 2023年2月. 渡邊毅, 有澤孝吉, Nguyen Van Tien, 石津将, 釜野桜子 :
コーヒー摂取と代謝表現型:J-MICC Studyのベースラインデータを用いた横断研究,
第33回日本疫学会学術総会, 2023年2月. 釜野桜子, 有澤孝吉, 石津将, 渡邊毅, Nguyen Van Tien, for the J-MICC Study Group :
朝食欠食および睡眠時間とメタボリック症候群との関連:J-MICC Study,
第264回徳島医学会学術集会, 2022年2月. Tien Van Nguyen, Kokichi Arisawa, Sakurako Kamano, Takeshi Watanabe, Masashi Ishizu and for the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study Group :
Associations of metabolic syndrome and metabolically unhealthy obesity with cancer mortality: Results of prospective cohort study in Japanese population,
第264回徳島医学会学術集会, Feb. 2022. Tien Van Nguyen, Kokichi Arisawa, Sakurako Katsuura-Kamano, Takeshi Watanabe, Masashi Ishizu and for the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study Group :
Associations of metabolic syndrome and metabolically unhealthy obesity with cancer mortality,
第32回日本疫学会学術総会, Jan. 2022. 釜野桜子, 有澤孝吉, 石津将, 渡邊毅, NGUYEN TIEN VAN, for the J-MICC Study Group :
大豆製品およびイソフラボン摂取量と全死亡・がん死亡との関連:J-MICC Study,
第32回日本疫学会学術総会, 2022年1月.

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補助金・競争的資金: 歯科治療時における疼痛、不安要因を軽減させるVR（仮想現実）システムの確立 (研究課題/領域番号: 24K20112 )
コホート・生体試料支援プラットフォーム (研究課題/領域番号: 22H04923 )
口腔内の慢性疼痛に対する期待感による鎮痛メカニズムの解析 (研究課題/領域番号: 20K18659 )
ASK-p38経路による核内受容体NR4Aファミリーのリン酸化制御と生理機能解析 (研究課題/領域番号: 12J09553 )
研究者番号（80815217）による検索

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2024年11月22日更新

専門分野・研究分野: 歯科学 (Dentistry)
疫学 (Epidemiology)
所属学会・所属協会: International Association for the Study of Pain
The Society for Interdisciplinary Placebo Studies
日本疫学会
歯科基礎医学会
日本生化学会
日本糖尿病・生活習慣病ヒューマンデータ学会
International Epidemiological Association
日本公衆衛生学会
委員歴・役員歴: International Association for the Study of Pain (IASP)
The Society for Interdisciplinary Placebo Studies (SIPS)
International Epidemiological Association (IEA)
日本公衆衛生学会 ( [2024年5月])
受賞: 2019年11月, 優秀臨床レポート賞 (一般社団法人博慈会)
活動: 日本多施設共同コーホート研究 (運営委員 [2024年4月])
四国公衆衛生学会 (幹事 [2024年4月])

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Jグローバル最終確認日: 2024/11/23 01:32
氏名（漢字）: 渡邊毅
氏名（フリガナ）: ワタナベタケシ
氏名（英字）: Watanabe Takeshi
所属機関: 徳島大学助教

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researchmap最終確認日: 2024/11/24 04:02
氏名（漢字）: 渡邊毅
氏名（フリガナ）: ワタナベタケシ
氏名（英字）: Watanabe Takeshi
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登録日時: 2018/10/18 22:46
更新日時: 2024/11/10 15:01
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eメール: watanabe.takeshi.2@tokushima-u.ac.jp
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所属: 徳島大学
部署: 大学院医歯薬学研究部予防医学
職名: 助教
学位: 歯学博士
学位授与機関: 東京医科歯科大学
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研究者番号: 80815217

所属（現在）: 2024/4/1 : 徳島大学, 大学院医歯薬学研究部(医学域), 助教

所属（過去の研究課題 情報に基づく）*注記: 2024/4/1 : 徳島大学, 大学院医歯薬学研究部(医学域), 助教
2021/4/1 – 2022/4/1 : 徳島大学, 大学院医歯薬学研究部(医学域), 助教
2020/4/1 : 東京医科歯科大学, 歯学部附属病院, 特任助教
2013/4/1 : 東京医科歯科大学, 大学院医歯学総合研究科, 特別研究員(DC2)
2012/4/1 : 東京医科歯科大学, 大学院・医歯学総合研究科, 特別研究員(DC2)

審査区分/研究分野: 研究代表者

医歯薬学 / 歯学 / 機能系基礎歯科学
小区分57060:外科系歯学関連
小区分57080:社会系歯学関連

キーワード

研究代表者

ノセボ効果 / プラセボ効果 / 期待感 / 不安感 / 歯科医療 / 慢性疼痛 / プラセボ―ム / ASK1 / p38 / 酸化ストレス / ネクローシス / NR4A2 / リン酸化 / 核外移行 / 核内受容体 / ASK1-p38MAPキナーゼ経路 / カスパーゼ非依存 / 細胞死 / 歯科治療 / VR / 痛み / 不快感

研究代表者以外

生体試料支援 / コホート / 臨床検体 / 一般健常人 / 大規模ゲノム解析・オミックス解析

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