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岩﨑智憲

徳島大学

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2024年12月4日更新

職名: 教授
電話: 088-633-7358
電子メール: iwasaki@tokushima-u.ac.jp
学歴: 1990/3: 鹿児島大学歯学部卒業
1994/3: 鹿児島大学大学院歯学研究科博士課程単位取得後退学
学位: 博士(歯学) (鹿児島大学) (2004年5月)
職歴・経歴: 1994/4: 鹿児島大学歯学部助手 (小児歯科)
2008/4: 鹿児島大学大学院助教医歯学総合研究科(小児歯科学分野)
2010/8: 鹿児島大学講師医学部・歯学部附属病院(小児歯科)
2014/5: 鹿児島大学大学院准教授医歯学総合研究科(小児歯科学分野)
2021/2: 徳島大学大学院教授医歯薬学研究部(小児歯科学分野)

専門分野・研究分野: 小児歯科学 (Pediatric Dentistry)

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2024年12月4日更新

専門分野・研究分野: 小児歯科学 (Pediatric Dentistry)
担当経験のある授業科目: (臨床系)国家試験・CBT対策講義 (学部)
2022年度臨床能力試験説明用コンテンツ (学部)
口腔と健康 (共通教育)
実践口腔科学実習 (大学院)
小児口腔保健学 (大学院)
小児歯科学 (大学院)
小児歯科学実習 (学部)
小児歯科学A 講義 (学部)
小児歯科学B 講義 (学部)
小児歯科学演習 (大学院)
小児歯科学総論 (学部)
歯科臨床示説 (学部)
発達系歯科学 (学部)
研究基礎ゼミ (学部)
統合臨床講義 (学部)
総合歯科学三 (学部)
総合歯科学二 (学部)
臨床医学概論 (大学院)
臨床医科学概論 (大学院)
英語論文作成法 (大学院)
障害者口腔保健衛生学 (学部)
顎口腔発育・社会歯科学実験実習 (大学院)
指導経験: 1人 (博士)

研究者総覧で最新データを確認する

2024年12月4日更新

専門分野・研究分野: 小児歯科学 (Pediatric Dentistry)

研究テーマ: 研究者総覧に該当データはありませんでした。

著書

岩﨑智憲 :
小児OSAに対する上顎急速拡大効果,
2020年10月. 岩﨑智憲, 佐藤秀夫, 山﨑要一 :
小児歯科学ベーシックテキスト，新谷誠康編集, --- 第3章頭蓋と顎の発育 4 口腔機能の発達 2 呼吸機能の発達 ---,
永末書店, 京都, 2019年3月. 岩﨑智憲, 武元嘉彦 :
小児歯科学第5版，白川哲夫，飯沼光生，福本敏編集, --- 第6章歯列咬合の発育と異常 III 歯列および咬合の異常 ---,
医歯薬出版株式会社, 東京, 2017年12月. 菅北斗, 岩﨑智憲 :
外科的矯正治療カラーアトラス，上山吉哉，森悦秀編集, --- 第4部症例報告上気道シミュレーションを用いて鼻腔通気状態を評価した，上下顎歯列の狭窄を認めた症例 ---,
九州大学出版会, 福岡, 2017年9月. 山﨑要一, 岩﨑智憲, 長谷川大子 :
機能的矯正療法入門，氷室利彦編集, --- 4章成長発育段階と機能的矯正療法 3.顎関節の成長発育 4.乳歯の異常と咬合の形成 5章口腔機能の評価 2.機能的評価呼吸機能と乳幼児期の咬合異常 ---,
東京臨床出版, 東京, 2017年2月. 岩﨑智憲, 山﨑要一 :
新よくわかる顎口腔機能，顎口腔機能学会編集, --- 小児の咬合;小児期における呼吸機能と下顎位 ---,
医歯薬出版株式会社, 東京, 2017年2月. 丸山崇, 酒井紀彰, 岩﨑智憲, 西野精治 :
睡眠科学，三島和夫編集, --- 2章睡眠覚醒を支える神経機構 ---,
株式会社化学同人, 京都, 2016年8月. 岩﨑智憲 :
日本歯科評論増刊2015 子どもの患者の治療・対応に上手くなろう! 各ステージにおける対応ポイント，朝田芳信編集, --- 顎運動，顎関節，歯の交換期についての評価と対応 ---,
株式会社ヒョーロン・パブリッシャーズ, 東京, 2015年10月. 岩﨑智憲 :
DH style増刊号子どものお口のスペシャリストになろう Vol.6, No.10，奥猛志，田中英一，早崎治明編集, --- 第3章咬合への対応咬合異常の種類と要因 ---,
株式会社デンタルダイヤモンド社, 東京, 2012年9月. 岩﨑智憲 :
小児歯科はいま，成育医療へ吉田昊哲，嘉ノ海龍三，山崎要一編集, --- 3．成長・発育 ② 上顎永久中切歯の萌出時における正中離開 ⑥ 永久中切歯が乳中切歯の舌側に萌出したとき ⑦ 上顎正中過剰歯による正中の偏位 ---,
株式会社デンタルダイヤモンド社, 東京, 2011年4月. 岩﨑智憲, 山崎要一 :
小児歯科学第4版高木裕三，田村康夫，井上美津子，白川哲夫編集, --- 第1編小児歯科学概論，7章歯列および咬合の発育と異常，Ⅲ 歯列および咬合の異常 ---,
医歯薬出版株式会社, 2011年3月. 岩﨑智憲, 山崎要一 :
世代をつなぐ小児歯科 - 最新情報と子どもへの取り組み 45 五十嵐清治，吉田昊哲編集, --- Ⅴ 咬合誘導への取り組み:6 診断分析の実際とその意義，各種診断法の紹介 ---,
クインテッセンス出版株式会社, 東京, 2009年3月.

論文

Takamasa Kitamura, Anna Uegomori-Yokura, Yoichiro Oku, Kei Maeo, Wakana Kohira, Yukari Suzuki, Yoshihito Yamakawa, Kimiko Ueda, Hideo Sato, Hiroko Ishimaru, Ryuzo Kanomi, Youichi Yamasaki and Tomonori Iwasaki :
Effects of adenoid hypertrophy on nasopharyngeal airway ventilation: A computational fluid dynamics study.,
International Journal of Pediatric Otorhinolaryngology, Vol.180, 2024.

(要約): of less than 5 mm on cephalometric images results in NA obstruction with substantially increased airflow resistance.
(キーワード): Humans / Adenoids / 子ども (children) / 男性 (male) / 女性 (female) / Hypertrophy / Cone-Beam Computed Tomography / Nasopharynx / Airway Resistance / Hydrodynamics / Cephalometry / Airway Obstruction / Retrospective Studies
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.ijporl.2024.111961
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38705134; ● Summary page in Scopus @ Elsevier: 2-s2.0-85192020417

(DOI: 10.1016/j.ijporl.2024.111961, PubMed: 38705134, Elsevier: Scopus) Linze Xia, Fumiya Kano, Noboru Hashimoto, Yao Liu, Tsendsuren Khurel-Ochir, Naoko Ogasawara, Cheng Ding, Yang Xu, Hideharu Hibi, Tomonori Iwasaki, Eiji Tanaka and Akihito Yamamoto :
Conditioned Medium From Stem Cells of Human Exfoliated Deciduous Teeth Alleviates Mouse Osteoarthritis by Inducing sFRP1-Expressing M2 Macrophages.,
Stem Cells Translational Medicine, Vol.13, No.4, 399-413, 2024.

(要約): Intravenous administration of conditioned medium from stem cells of human exfoliated deciduous teeth (SHED-CM) regenerates mechanically injured osteochondral tissues in mouse temporomandibular joint osteoarthritis (TMJOA). However, the underlying therapeutic mechanisms remain unclear. Here, we showed that SHED-CM alleviated injured TMJ by inducing anti-inflammatory M2 macrophages in the synovium. Depletion of M2 by Mannosylated Clodrosome abolished the osteochondral repair activities of SHED-CM. Administration of CM from M2-induced by SHED-CM (M2-CM) effectively ameliorated mouse TMJOA by inhibiting chondrocyte inflammation and matrix degradation while enhancing chondrocyte proliferation and matrix formation. Notably, in vitro, M2-CM directly suppressed the catabolic activities while enhancing the anabolic activities of interleukin-1β-stimulated mouse primary chondrocytes. M2-CM also inhibited receptor activator of nuclear factor NF-κB ligand-induced osteoclastogenesis in RAW264.7 cells. Secretome analysis of M2-CM and M0-CM revealed that 5 proteins related to anti-inflammation and/or osteochondrogenesis were enriched in M2-CM. Of these proteins, the Wnt signal antagonist, secreted frizzled-related protein 1 (sFRP1), was the most abundant and played an essential role in the shift to anabolic chondrocytes, suggesting that M2 ameliorated TMJOA partly through sFRP1. This study suggests that secretome from SHED exerted remarkable osteochondral regeneration activities in TMJOA through the induction of sFRP1-expressing tissue-repair M2 macrophages.
(キーワード): Humans / Mice / Animals / Culture Media, Conditioned / Stem Cells / Macrophages / Osteoarthritis / Anti-Inflammatory Agents / Tooth, Deciduous
(出版サイトへのリンク): ● Publication site (DOI): 10.1093/stcltm/szae006
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38366885; ● Summary page in Scopus @ Elsevier: 2-s2.0-85190754023

(DOI: 10.1093/stcltm/szae006, PubMed: 38366885, Elsevier: Scopus) Soujiro HIsagai, Kacey Li, Tomonori Iwasaki, Toshiya tsujii, Rina Sakoda-Iwata, Youichiro Oku, Yuusuke Ban, Hideo Sato and Youichi Yamasaki :
Exploring the Widespread Effectiveness of Maxillomandibular Advancement,
Journal of Oral Health and Biosciences, Vol.35, No.2, 71-79, 2023.

(キーワード): OSA / CFD / Maxillomandibular Advancement
(徳島大学機関リポジトリ): ● Metadata: 118170
(出版サイトへのリンク): ● Publication site (DOI): 10.20738/johb.35.2_71
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.20738/johb.35.2_71

(徳島大学機関リポジトリ: 118170, DOI: 10.20738/johb.35.2_71) Yochiro Oku, Tomonori Iwasaki, Toshiya Tsujii, Rina Skoda-Iwata, Soujiro Hisagai, Yuusuke Ban, Hido Sato, Hitomi Ishii, Ryuzo Kanmi and Youichi Yamasaki :
Effect of palatine tonsil hypertrophy on tongue posture and maxillofacial dentition: A pharyngeal airway computational fluid dynamics study,
Pediatric Dental Journal, Vol.33, 42-51, 2023.

(キーワード): Tonsil / CFD / Tongue
(徳島大学機関リポジトリ): ● Metadata: 119012
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.pdj.2023.01.003
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1016/j.pdj.2023.01.003

(徳島大学機関リポジトリ: 119012, DOI: 10.1016/j.pdj.2023.01.003) Rina-Iwata Sakoda, Tomonori Iwasaki, Toshiya Tsujii, Soujiro Hisagai, Yoichiro Oku, Yusuke Ban, hideo Sato, Hitomi IshiI, Ryuuzo Kanomi and Youchi Yamasaki :
Does rapid maxillary expansion improve nasal airway obstruction? A computer fluid dynamics study in patients with nasal mucosa hypertrophy and obstructive adenoids,
American Journal of Orthodontics and Dentofacial Orthopedics (AJO-DO), Vol.164, No.1, e1-e13, 2023.

(要約): Rapid maxillary expansion (RME) expands the maxillary dentition laterally and improves nasal airway obstruction. However, the incidence of nasal airway obstruction improvement after RME is approximately 60%. This study aimed to clarify the beneficial effects of RME on nasal airway obstruction in specific pathologic nasal airway diseases (nasal mucosa hypertrophy and obstructive adenoids) using computer fluid dynamics. Sixty subjects (21 boys; mean age 9.1 years) were divided into 3 groups according to their nasal airway condition (control, nasal mucosa hypertrophy, and obstructive adenoids), and those requiring RME had cone-beam computed tomography images taken before and after RME. These data were used to evaluate the nasal airway ventilation condition (pressure) using computer fluid dynamics and measure the cross-sectional area of the nasal airway. The cross-sectional area of the nasal airway significantly increased after RME in all 3 groups. The pressures in the control and nasal mucosa groups significantly reduced after RME but did not change significantly in the adenoid group. The incidence of improvement in nasal airway obstruction in the control, nasal mucosa, and adenoid groups was 90.0%, 31.6%, and 23.1%, respectively. The incidence of improvement in nasal airway obstruction after RME depends on the nasal airway condition (nasal mucosa hypertrophy and obstructive adenoids). In patients with nonpathologic nasal airway conditions, the obstruction may be sufficiently improved with RME. Furthermore, to some extent, RME may be effective in treating nasal mucosa hypertrophy. However, because of obstructive adenoids, RME was ineffective in patients with nasal airway obstruction.
(キーワード): CFD / rapid maxillary expansion / nasal airway
(徳島大学機関リポジトリ): ● Metadata: 119011
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.ajodo.2023.04.014
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37191595; ● Search Scopus @ Elsevier (PMID): 37191595; ● Search Scopus @ Elsevier (DOI): 10.1016/j.ajodo.2023.04.014

(徳島大学機関リポジトリ: 119011, DOI: 10.1016/j.ajodo.2023.04.014, PubMed: 37191595) Linze XIA, Fumiya Kano, Noboru Hashimoto, Cheng DING, Yang XU, Hideharu HIBI, Tomonori Iwasaki, Eiji Tanaka and Akihito Yamamoto :
Conditioned Medium from Stem Cells of Human Exfoliated Deciduous Teeth Partially Alters the Expression of Inflammation-associated Molecules of Mouse Condylar Chondrocytes via Secreted Frizzled-related Protein 1,
Journal of Oral Health and Biosciences, Vol.35, No.2, 52-60, 2023.

(徳島大学機関リポジトリ): ● Metadata: 118150
(出版サイトへのリンク): ● Publication site (DOI): 10.20738/johb.35.2_52
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.20738/johb.35.2_52

(徳島大学機関リポジトリ: 118150, DOI: 10.20738/johb.35.2_52) Fumiya Kano, Noboru Hashimoto, Yao Liu, Linze Xia, Takaaki Nishihara, Wakana Oki, Keita Kawarabayashi, Noriko Mizusawa, Keiko Aota, Takayoshi Sakai, Masayuki Azuma, Hideharu Hibi, Tomonori Iwasaki, Tsutomu Iwamoto, Nobuyasu Horimai and Akihito Yamamoto :
Therapeutic benefits of factors derived from stem cells from human exfoliated deciduous teeth for radiation-induced mouse xerostomia,
Scientific Reports, Vol.13, No.1, 2706-2719, 2023.

(要約): Radiation therapy for head and neck cancers is frequently associated with adverse effects on the surrounding normal tissue. Irreversible damage to radiation-sensitive acinar cells in the salivary gland (SG) causes severe radiation-induced xerostomia (RIX). Currently, there are no effective drugs for treating RIX. We investigated the efficacy of treatment with conditioned medium derived from stem cells from human exfoliated deciduous teeth (SHED-CM) in a mouse RIX model. Intravenous administration of SHED-CM, but not fibroblast-CM (Fibro-CM), prevented radiation-induced cutaneous ulcer formation (p < 0.0001) and maintained SG function (p < 0.0001). SHED-CM treatment enhanced the expression of multiple antioxidant genes in mouse RIX and human acinar cells and strongly suppressed radiation-induced oxidative stress. The therapeutic effects of SHED-CM were abolished by the superoxide dismutase inhibitor diethyldithiocarbamate (p < 0.0001). Notably, quantitative liquid chromatography-tandem mass spectrometry shotgun proteomics of SHED-CM and Fibro-CM identified eight proteins activating the endogenous antioxidant system, which were more abundant in SHED-CM than in Fibro-CM (p < 0.0001). Neutralizing antibodies against those activators reduced antioxidant activity of SHED-CM (anti-PDGF-D; p = 0.0001, anti-HGF; p = 0.003). Our results suggest that SHED-CM may provide substantial therapeutic benefits for RIX primarily through the activation of multiple antioxidant enzyme genes in the target tissue.
(キーワード): Mice / Humans / Animals / Antioxidants / Stem Cells / Disease Models, Animal / Xerostomia / Tooth, Deciduous
(徳島大学機関リポジトリ): ● Metadata: 118051
(出版サイトへのリンク): ● Publication site (DOI): 10.1038/s41598-023-29176-w
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36792628; ● Summary page in Scopus @ Elsevier: 2-s2.0-85148115146

(徳島大学機関リポジトリ: 118051, DOI: 10.1038/s41598-023-29176-w, PubMed: 36792628, Elsevier: Scopus) Anrizandy Narwidina, Aya Miyazaki, Kokoro Iwata, Rika Kurogoushi, Asuna Sugimoto, Yasusei Kudo, Keita Kawarabayashi, Yoshihito Yamakawa, Yuki Akazawa, Takamasa Kitamura, Hiroshi Nakagawa, Kimiko Ueda Yamaguchi, Tomokazu Hasegawa, Keigo Yoshizaki, Satoshi Fukumoto, Akihito Yamamoto, Naozumi Ishimaru, Tomonori Iwasaki and Tsutomu Iwamoto :
Iroquois homeobox 3 regulates odontoblast proliferation and differentiation mediated by Wnt5a expression.,
Biochemical and Biophysical Research Communications, Vol.650, 47-54, 2023.

(要約): Iroquois homeobox (Irx) genes are TALE-class homeobox genes that are evolutionarily conserved across species and have multiple critical cellular functions in fundamental tissue development processes. Previous studies have shown that Irxs genes are expressed during tooth development. However, the precise roles of genes in teeth remain unclear. Here, we demonstrated for the first time that Irx3 is an essential molecule for the proliferation and differentiation of odontoblasts. Using cDNA synthesized from postnatal day 1 (P1) tooth germs, we examined the expression of all Irx genes (Irx1-Irx6) by RT-PCR and found that all genes except Irx4 were expressed in the tooth tissue. Irx1-Irx3 a were expressed in the dental epithelial cell line M3H1 cells, while Irx3 and Irx5 were expressed in the dental mesenchymal cell line mDP cells. Only Irx3 was expressed in both undifferentiated cell lines. Immunostaining also revealed the presence of IRX3 in the dental epithelial cells and mesenchymal condensation. Inhibition of endogenous Irx3 by siRNA blocks the proliferation and differentiation of mDP cells. Wnt3a, Wnt5a, and Bmp4 are factors involved in odontoblast differentiation and were highly expressed in mDP cells by quantitative PCR analysis. Interestingly, the expression of Wnt5a (but not Wnt3a or Bmp4) was suppressed by Irx3 siRNA. These results suggest that Irx3 plays an essential role in part through the regulation of Wnt5a expression during odontoblast proliferation and differentiation.
(キーワード): Homeodomain Proteins / Transcription Factors / Odontoblasts / Genes, Homeobox / 細胞分化 (cell differentiation) / 細胞増殖·分化 (cell proliferation and differentiation)
(徳島大学機関リポジトリ): ● Metadata: 118052
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.bbrc.2023.02.004
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36773339; ● Search Scopus @ Elsevier (PMID): 36773339; ● Search Scopus @ Elsevier (DOI): 10.1016/j.bbrc.2023.02.004

(徳島大学機関リポジトリ: 118052, DOI: 10.1016/j.bbrc.2023.02.004, PubMed: 36773339) 岩﨑智憲, 猪子芳美, 鈴木浩司, 佐藤光生, 鈴木善貴 :
睡眠歯科の用語集第2版日本睡眠歯科学術用語部会,
睡眠口腔医学, Vol.9, No.2, 36-41, 2023年.

(キーワード): 用語集 / 睡眠医学 / 睡眠歯科
(出版サイトへのリンク): ● Publication site (DOI): 10.24695/josm.9.2_36
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390858441639042560; ● Search Scopus @ Elsevier (DOI): 10.24695/josm.9.2_36

(DOI: 10.24695/josm.9.2_36, CiNii: 1390858441639042560) Kasey Li, Tomonori Iwasaki, Stacey Quo, Connor Li, Kara Young, Eileen Leary, Christian Guilleminault and Philippe Amat :
Persistent pediatric obstructive sleep apnea treated with skeletally anchored transpalatal distraction,
L' Orthodontie Française, Vol.93, No.2, 139-153, 2022.

(要約): Nasomaxillary expansion by skeletally anchored TPD improves OSA in children without transverse maxillary deficiency that were previously treated by RPE. A nearly parallel anterior-posterior opening of the mid-palatal suture achieves enlargement of the entire nasal passage with improvement of the airflow characteristics in the nasal and pharyngeal airway. The improved airflow characteristic is significantly correlated with the improved polysomnographic findings, thus demonstrating that nasomaxillary expansion in previously expanded patients is a viable treatment option.
(キーワード): Cone-Beam Computed Tomography / Humans / Nose / Palatal Expansion Technique / Pharynx / Sleep Apnea, Obstructive
(出版サイトへのリンク): ● Publication site (DOI): 10.1684/orthodfr.2022.82
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35818284; ● Summary page in Scopus @ Elsevier: 2-s2.0-85133814839

(DOI: 10.1684/orthodfr.2022.82, PubMed: 35818284, Elsevier: Scopus) 黒厚子璃佳, 岩田こころ, 中川弘, 長谷川智一, 上田(山口) 公子, 北村尚正, 赤澤友基, 杉本明日菜, 河原林啓太, 宮嵜彩, 尼寺理恵, 藤島史帆, 岩﨑智憲, 岩本勉 :
当科における5年間の障害児・有病児の初診時実態調査,
小児歯科学雑誌, Vol.60, No.1, 20-27, 2022年.

(要約): 障害児や有病児への理解の深まりから社会環境や福祉制度の整備が進みつつあるが，障害や全身疾患をもつ児が地域において疾病予防も含めた歯科医療を受けられる環境がいまだ十分にあるとは言えず，実情に応じた環境整備が求められる．そこで，今回，平成25年度から平成29年度に当科を受診した児のうち障害児・有病児の5年間の初診時実態調査を行い，過去に当科で行った調査と比較し，近年の変化を検討した．初診患者1,301名のうち，障害児・有病児の割合は49
(キーワード): う蝕先天奇形口蓋裂口唇裂 *障害者歯科医療発達障害染色体異常 *小児歯科医療 *慢性疾患患者歯科医療 *病院歯科診療部門紹介と相談年齢因子徳島県実態調査地域差ヒト小児(6∼12) 男女歯学
(出版サイトへのリンク): ● Publication site (DOI): 10.11411/jspd.60.1_20
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390295259235197952; ● Search Scopus @ Elsevier (DOI): 10.11411/jspd.60.1_20

(DOI: 10.11411/jspd.60.1_20, CiNii: 1390295259235197952) Rika Kurogoushi, Tomokazu Hasegawa, Yuki Akazawa, Kokoro Iwata, Asuna Sugimoto, Kimiko Ueda Yamaguchi, Aya Miyazaki, Anrizandy Narwidina, Keita Kawarabayashi, Takamasa Kitamura, Hiroshi Nakagawa, Tomonori Iwasaki and Tsutomu Iwamoto :
Fibroblast growth factor 2 suppresses the expression of C-C motif chemokine 11 through the c-Jun N-terminal kinase pathway in human dental pulp-derived mesenchymal stem cells,
Experimental and Therapeutic Medicine, Vol.22, No.6, 1356, 2021.

(要約): The regulation of the mesenchymal stem cell (MSC) programming mechanism promises great success in regenerative medicine. Tissue regeneration has been associated not only with the differentiation of MSCs, but also with the microenvironment of the stem cell niche that involves various cytokines and immune cells in the tissue regeneration site. In the present study, fibroblast growth factor 2 (FGF2), the principal growth factor for tooth development, dental pulp homeostasis and dentin repair, was reported to affect the expression of cytokines in human dental pulp-derived MSCs. FGF2 significantly inhibited the expression of chemokine C-C motif ligand 11 (CCL11) in a time- and dose-dependent manner in the SDP11 human dental pulp-derived MSC line. This inhibition was diminished following treatment with the AZD4547 FGF receptor (FGFR) inhibitor, indicating that FGF2 negatively regulated the expression of CCL11 in SDP11 cells. Furthermore, FGF2 activated the phosphorylation of p38 mitogen-activated protein kinase (p38 MAPK), extracellular signal-regulated kinase 1/2 (ERK1/2) and c-Jun N-terminal kinases (JNK) in SDP11 cells. The mechanism of the FGFR-downstream signaling pathway was then studied using the SB203580, U0126 and SP600125 inhibitors for p38 MAPK, ERK1/2, and JNK, respectively. Interestingly, only treatment with SP600125 blocked the FGF2-mediated suppression of CCL11. The present results suggested that FGF2 regulated the expression of cytokines and suppressed the expression of CCL11 via the JNK signaling pathway in human dental pulp-derived MSCs. The present findings could provide important insights into the association of FGF2 and CCL11 in dental tissue regeneration therapy.
(徳島大学機関リポジトリ): ● Metadata: 117039
(出版サイトへのリンク): ● Publication site (DOI): 10.3892/etm.2021.10791
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34659502; ● Search Scopus @ Elsevier (PMID): 34659502; ● Search Scopus @ Elsevier (DOI): 10.3892/etm.2021.10791

(徳島大学機関リポジトリ: 117039, DOI: 10.3892/etm.2021.10791, PubMed: 34659502) Tomonori Iwasaki, Spyridon N. Papageorgiou, Youichi Yamasaki, M. Ali Darendeliler and Alexandra K. Papadopoulou :
Papadopoulou, Nasal ventilation and rapid maxillary expansion(RME): a randomized trial,
European Journal of Orthodontics, Vol.43, No.3, 283-292, 2021.

(要約): To assess three rapid maxillary expansion (RME) appliances in nasal ventilation. Three-arm parallel randomized clinical trial. Sixty-six growing subjects (10-16 years old) needing RME as part of their orthodontic treatment were randomly allocated (1:1:1 ratio) to three groups of 22 patients receiving Hyrax (H), Hybrid-Hyrax (HH), or Keles keyless expander (K). The primary outcome of nasal ventilation (pressure and velocity) and secondary outcomes (skeletal, dental, soft tissue, and nasal obstruction changes) were blindly assessed on the initial (T0) and final (T1, 6 months at appliance removal) cone-beam computed tomography (CBCT) data by applying computational fluid dynamics (CFD) method. Differences across groups were assessed with crude and adjusted for baseline values and confounders (gender, age, skeletal maturation, expansion amount, mucosal/adenoid hypertrophy, nasal septum deviation) regression models with alpha = 5%. Fifty-four patients were analysed (19H, 21HH, 14K). RME reduced both nasal pressure (H: -45.8%, HH: -75.5%, K: -63.2%) and velocity (H: -30%, HH: -58.5%, K: -35%) accompanied with nasal obstruction resolution (H: 26%, HH: 62%, K: 50%). Regressions accounting for baseline severity indicated HH expander performing better in terms of post-expansion maximum velocity (P = 0.03) and nasal obstruction resolution (P = 0.04), which was robust to confounders. Mucosal/adenoid hypertrophy and nasal septum deviation changes were variable, minimal, and similar across groups. The HH resulted in significantly greater increase in the nasal cross-sectional area (62.3%), anterior (14.6%), and posterior (10.5%) nasal widths. Nasal obstruction resolution was more probable among younger (P = 0.04), skeletally immature (P = 0.03), and male patients (P = 0.02) without pre-treatment mucosal hypertrophy (P = 0.04), while HH was associated with marginal greater probability for obstruction resolution. RME resulted in improvement of nasal skeletal parameters and simulated ventilation with the former being in favour of the HH and the latter not showing significant differences among the three appliances. Attrition in the K group due to blocked activation rods possibly leading to limited sample to identify any existing group differences. Replacement of blocked Keles expanders for finalizing treatment. The protocol was not published before the trial commencement. Australian and New Zealand Clinical Trial Registry; ACTRN12617001136392.
(キーワード): Adolescent / Australia / Child / Cone-Beam Computed Tomography / Humans / Male / Maxilla / Nose / Palatal Expansion Technique / Respiration
(出版サイトへのリンク): ● Publication site (DOI): 10.1093/ejo/cjab001
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33564835; ● Search Scopus @ Elsevier (PMID): 33564835; ● Search Scopus @ Elsevier (DOI): 10.1093/ejo/cjab001

(DOI: 10.1093/ejo/cjab001, PubMed: 33564835) Emina Msuda, Akiko Ishizaki, Kojiro Hirano, Tomonori Iwasaki and Takehiko Sambe :
Computational fluid dynamics analysis in patients with nasal disease,
The Showa University Journal of Medical Sciences, Vol.33, No.3, 88-95, 2021.

(キーワード): acoustic rhinometry / allergic rhinitis / 数値流体力学 (computational fluid dynamics) / rhinomanometry / sinusitis
(徳島大学機関リポジトリ): ● Metadata: 117486
(出版サイトへのリンク): ● Publication site (DOI): 10.15369/sujms.33.88
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390570884497169920; ● Search Scopus @ Elsevier (DOI): 10.15369/sujms.33.88

(徳島大学機関リポジトリ: 117486, DOI: 10.15369/sujms.33.88, CiNii: 1390570884497169920) Tatsunori Takahashi, Noriaki Sakai, Tomonori Iwasaki, Timothy C. Doyle, William C. Mobley and Seiji Nishino :
Detailed evaluation of the upper airway in the Dp(16)1Yey mouse model of Down syndrome.,
Scientific Reports, Vol.10, No.1, 21323, 2020.

(要約): A high prevalence of obstructive sleep apnea (OSA) has been reported in Down syndrome (DS) owing to the coexistence of multiple predisposing factors related to its genetic abnormality, posing a challenge for the management of OSA. We hypothesized that DS mice recapitulate craniofacial abnormalities and upper airway obstruction of human DS and can serve as an experimental platform for OSA research. This study, thus, aimed to quantitatively characterize the upper airway as well as craniofacial abnormalities in Dp(16)1Yey (Dp16) mice. Dp16 mice demonstrated craniofacial hypoplasia, especially in the ventral part of the skull and the mandible, and rostrally positioned hyoid. These changes were accompanied with a shorter length and smaller cross-sectional area of the upper airway, resulting in a significantly reduced upper airway volume in Dp16 mice. Our non-invasive approach, a combination of computational fluid dynamics and high-resolution micro-CT imaging, revealed a higher negative pressure inside the airway of Dp16 mice compared to wild-type littermates, showing the potential risk of upper airway collapse. Our study indicated that Dp16 mice can be a useful model to examine the pathophysiology of increased upper airway collapsibility of DS and to evaluate the efficacy of therapeutic interventions for breathing and sleep anomalies.
(徳島大学機関リポジトリ): ● Metadata: 115758
(出版サイトへのリンク): ● Publication site (DOI): 10.1038/s41598-020-78278-2
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33288820; ● Summary page in Scopus @ Elsevier: 2-s2.0-85097263038

(徳島大学機関リポジトリ: 115758, DOI: 10.1038/s41598-020-78278-2, PubMed: 33288820, Elsevier: Scopus) Tomonori Iwasaki, Takesi Sugiyama, Ayaka Yanagisawa-Minami, Yoichiro Oku, Anna Yokura and Youichi Yamasaki :
Effect of adenoids and tonsil tissue on pediatric obstructive sleep apnea severity determined by computational fluid dynamics.,
Journal of Clinical Sleep Medicine, Vol.16, No.12, 2021-2028, 2020.

(要約): Obstructive sleep apnea (OSA) is a respiratory disorder caused by the obstruction of the upper airway during sleep. The most common cause of pediatric OSA is adenotonsillar hypertrophy. Adenotonsillectomy is the first-line treatment for pediatric OSA; however, OSA persists in a significant number of patients due, in part, to the method of evaluating enlarged adenoids and tonsil tissue. The reason for these effects on OSA severity is not clear. This study aimed to establish a method to diagnose the need for adenoidectomy or tonsillectomy. Twenty-seven Japanese children (mean age 6.6 years) participated in this study, undergoing polysomnography and computed tomography examination. Pharyngeal airway morphology (adenoids and tonsil tissue size, volume, and cross-sectional area [CSA]) and pressure on the upper airway were evaluated at each site using computational fluid dynamic analysis. Apnea-hypopnea index (AHI) showed a strong linear association with maximum negative pressure (P) (AHI = -0.055* events/h P -1.326, R² = .805). The relationship between minimum CSA (CSA) and P was represented by an inversely proportional fitted curve (P = -4797/CSA -5.1, R² = .507). The relationship between CSA and AHI was also represented by an inversely proportional fitted curve (AHI = 301.6 events/h/CSA, R² = .680). P greatly increased if CSA became ≤ 30 mm². The negative pressure of each site increased when CSA measured ≤ 50 mm². In children, when the CSA for each site is ≤ 50 mm², AHI is likely to be elevated, and the patient may require tonsillectomy or adenoidectomy.
(徳島大学機関リポジトリ): ● Metadata: 116138
(出版サイトへのリンク): ● Publication site (DOI): 10.5664/jcsm.8736
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32780013; ● Summary page in Scopus @ Elsevier: 2-s2.0-85097943521

(徳島大学機関リポジトリ: 116138, DOI: 10.5664/jcsm.8736, PubMed: 32780013, Elsevier: Scopus) Yoshito Shirazawa, Tomonori Iwasaki, Kazuhiro Ooi, Yutaka Kobayashi, Ayaka Yanagisawa-Minami, Yoichiro Oku, Anna Yokura, Yuusuke Ban, Hokuto Suga, Shuichi Kawashiri and Youichi Yamasaki :
Relationship between pharyngeal airway depth and ventilation condition in mandibular setback surgery: A computational fluid dynamics study.,
Orthodontics & Craniofacial Research, Vol.23, No.3, 313-322, 2020.

(要約): This study aimed to determine the anteroposterior depth (APD) of the pharyngeal airway (PA) where post-operative PA obstruction was predicted, using computer fluid dynamics (CFD), in order to prevent obstructive sleep apnoea after mandibular setback surgery. Nineteen skeletal Class III patients (8 men; mean age, 26.7 years) who required mandibular setback surgery had computed tomography images taken before and 6 months after surgery. The APD of each site of the four cross-sectional reference planes (retropalatal airway [RA], second cervical vertebral airway, oropharyngeal airway and third cervical vertebral airway) were measured. The Maximum negative pressure (Pmax) of the PA was measured at inspiration using CFD, based on a three-dimensional PA model. Intersite differences were determined using analysis of variance and the Friedman test with Bonferroni correction. The relationship between APD and Pmax was evaluated by Spearman correlation coefficients and non-linear regression analysis. The smallest PA site was the RA. Pmax was significantly correlated with the APD of the RA (r = .628, P < .001). The relationship between Pmax and the APD-RA was fitted to a curve, which showed an inversely proportional relationship of Pmax to the square of the APD-RA. Pmax substantially increased even with a slight reduction of the APD-RA. In particular, when the APD-RA was 7 mm or less, Pmax increased greatly, suggesting that PA obstruction was more likely to occur. The results of this study suggest that APD-RA is a useful predictor of good PA ventilation after surgery.
(キーワード): Adult / Cephalometry / Cross-Sectional Studies / Humans / Hydrodynamics / 男性 (male) / Malocclusion, Angle Class III / Mandible / Orthognathic Surgical Procedures / Pharynx
(出版サイトへのリンク): ● Publication site (DOI): 10.1111/ocr.12371
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32056328; ● Summary page in Scopus @ Elsevier: 2-s2.0-85080968387

(DOI: 10.1111/ocr.12371, PubMed: 32056328, Elsevier: Scopus) Tomonori Iwasaki, Audrey Yoon, Christian Guilleminault, Youichi Yamasaki and Stanley Yung Liu :
How does distraction osteogenesis maxillary expansion (DOME) reduce severity of obstructive sleep apnea?,
Sleep & Breathing = Schlaf & Atmung, Vol.24, No.1, 287-296, 2020.

(要約): Distraction osteogenesis maxillary expansion (DOME) is a reliable method to expand the nasal floor and hard palatal vault in adults with obstructive sleep apnea (OSA). DOME results in a reduction in the apnea-hypopnea index (AHI) and subjective report of improved nasal breathing. Using rhinomanometry augmented computational fluid dynamic (CFD) modeling, we propose a mechanism of how DOME reduces upper airway pharyngeal collapse in adults with OSA. A retrospective cohort with 20 subjects and mean age of 29.6 ± 8 years who completed DOME at Stanford University from September 2014 to April 2016. Subjects were included if polysomnography, airway morphology, and rhinomanometry were available for use. From the CBCT data, 3D nasal and pharyngeal airway model were generated. Numeric CFD simulation of the airway models were analyzed under the following conditions: (1) the volume of air was flowing at a velocity of 300 cm/s, (2) the wall surface was not slippery, and (3) the simulations were repeated 1000 times to calculate mean values. Statistical analyses using SPSS v24 software included paired t tests, nonparametric Wilcoxon rank test, Friedman test with Bonferroni correction, and Spearman's correlation coefficients (p < 0.05). Mean AHI improved from 17.8 ± 17.6 to 7.8 ± 7.1 events per hour (p < 0.001). Mean lowest oxygen saturation improved from 88.2 ± 7.2 to 90.9 ± 4.2% (p < 0.05). Mean airflow velocity within the nasal airway decreased from 15.6 ± 7.3 to 7.4 ± 2.1 m/s (p < 0.001) after DOME. Mean negative pressure of the nasal airway, retropalatal airway, oropharyngeal airway, and hypopharyngeal airway is reduced from - 158.4 ± 115.3 to - 48.6 ± 28.7 Pa, from - 174.8 ± 119.9 to - 52.5 ± 31.3 Pa, from - 177.0 ± 118.4 to - 54.9 ± 31.8 Pa and from - 177.9 ± 117.9 to - 56.9 ± 32.1 Pa (p < 0.001), respectively. AHI positively correlated with nasal flow velocity (p < 0.05) and negatively correlated with pharyngeal airway pressure (p < 0.05). ODI was positively correlated with nasal velocity (p < 0.05) and negatively correlated with nasal airway pressure (p < 0.05), retropalatal airway pressure (p < 0.001), oropharyngeal airway pressure (p < 0.001), and hypopharyngeal airway pressure (p < 0.05). Anatomic expansion of the nasal floor with widening of the hard palatal vault from DOME is associated with reduction of nasal airflow velocity and downstream reduction of negative pressure in the pharyngeal airway. This dynamic interaction correlates with a reduction in the apnea-hypopnea index (AHI) and Oxygen Desaturation Index (ODI).
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s11325-019-01948-7
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31823220; ● Summary page in Scopus @ Elsevier: 2-s2.0-85076768795

(DOI: 10.1007/s11325-019-01948-7, PubMed: 31823220, Elsevier: Scopus) Ayaka Yanagisawa-Minami, Takeshi Sugiyama, Tomonori Iwasaki and Youichi Yamasaki :
Primary site identification in children with obstructive sleep apnea by computational fluid dynamics analysis of the upper airway.,
Journal of Clinical Sleep Medicine, Vol.16, No.3, 431-439, 2020.

(要約): Obstructive sleep apnea (OSA) is a respiratory disorder caused by the obstruction of the upper airway during sleep. The identification of the primary site of OSA is essential to determine treatment strategy. This study aimed to establish computational fluid dynamics (CFD) analysis for determining the clinical severity of OSA and the primary site of OSA. Twenty children (mean age, 6 years) were divided into OSA and control groups according to their apnea-hypopnea index. Three-dimensional airways were constructed from computed tomography data. The pharyngeal airway morphology and the pressure and velocity of the upper airway were evaluated using CFD analysis. The maximum velocity and negative pressure of the upper airway in the OSA group were significantly correlated with the severity of OSA (r = .741, P < .001; r = -.653, P = .002). A velocity higher than 12 m/s indicated the primary site of OSA. In addition, we found that the primary site of OSA is not necessarily the same as the collapsible conduit site. CFD analysis allows both the evaluation of the disease severity of OSA and the identification of the primary site of OSA in children. The primary site of OSA is not necessarily the same as the collapsible conduit site; therefore, CFD analysis can be used to identify the appropriate intervention for treating OSA.
(徳島大学機関リポジトリ): ● Metadata: 116137
(出版サイトへのリンク): ● Publication site (DOI): 10.5664/jcsm.8224
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31992411; ● Summary page in Scopus @ Elsevier: 2-s2.0-85082147235

(徳島大学機関リポジトリ: 116137, DOI: 10.5664/jcsm.8224, PubMed: 31992411, Elsevier: Scopus) Hiroyuki Nakano, Katsuaki Mishima, Hokuto Suga, Tomonori Iwasaki, Kazuya Inoue, Takamitsu Mano, Chikara Yoshimura, Kei Suzuki, Naoko Imagawa, Takaaki Ueno, Yoshihide Mori and Yoshiya Ueyama :
The Effect of Cranial Change on Oropharyngeal Airway and Breathing During Sleep,
Journal of Hard Tissue Biology, Vol.29, No.1, 49-52, 2020.

(要約): Mandibular micrognathia is one of the characteristics of obstructive sleep apnea syndrome. The purpose of this study was to assess the effects of bimaxillary surgery without maxillary advancement on the upper airway using computational fluid dynamics (CFD) results of comparing pre- and post-operative finite element model. Seven female patients with jaw deformity, who underwent two-jaw surgery (Le Fort1 osteotomy and bilateral sagittal split ramus osteotomy; BSSRO) were enrolled. Maxillary was moved for correcting occlusal plane and mandibular was moved to advancement. Pharyngeal airway space and breathing during sleep were evaluated, comparing the periods of 2 days before and 6 months after the operation. The cross-sectional area of the level of the hard palate (HP) and the level of the tip of the uvula (TU), and airway volume of total, HP-TU, and TP- the level of the base of the epiglottis (BE) were increased. AI and AHI in 2 days before and 6 months after were decreased. As the result of nasal ventilation condition, velocity of HP and TU in 2 days before and 6 months after were decreased. We think that it was revealed that movement of the maxilla without advancement did not affect to the morphology and function of airway.
(キーワード): Cranial change / Bimaxillary surgery / Oropharyngeal surgery / Breathing during sleep / 数値流体力学 (computational fluid dynamics)
(徳島大学機関リポジトリ): ● Metadata: 115789
(出版サイトへのリンク): ● Publication site (DOI): 10.2485/jhtb.29.49
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390283659847882624; ● Search Scopus @ Elsevier (DOI): 10.2485/jhtb.29.49

(徳島大学機関リポジトリ: 115789, DOI: 10.2485/jhtb.29.49, CiNii: 1390283659847882624) Yoko Iwase, Issei Saitoh, Atsuyoshi Okamoto, Mie Kurosawa, Yuki Nakamura, Emi Inada, Tomonori Iwasaki, Youichi Yamasaki and Haruaki Hayasaki :
Comparison of dynamic occlusal contacts during chewing between children with primary dentition and normal adult females,
Pediatric Dental Journal, Vol.29, No.3, 116-122, 2019.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.pdj.2019.07.004
(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-85070557531

(DOI: 10.1016/j.pdj.2019.07.004, Elsevier: Scopus) Tomonori Iwasaki, Hokuto Suga, Ayaka Yanagisawa-Minami, Hideo Sato, Makiko Sato-Hashiguchi, Yoshito Shirazawa, Toshiya Tsujii, Yuushi Yamamoto, Ryuzo Kanomi and Youichi Yamasaki :
Relationships among tongue volume, hyoid position, airway volume and maxillofacial form in paediatric patients with Class-I, Class-II and Class-III malocclusions.,
Orthodontics & Craniofacial Research, Vol.22, No.1, 9-15, 2019.

(要約): To clarify the associations among tongue volume, hyoid position, airway volume and maxillofacial form using cone beam computed tomography (CBCT) data for children with Class-I, Class-II and Class-III malocclusion. Sixty children (mean age, 9.2 years) divided into Class-I, Class-II and Class-III malocclusion groups according to the A-nasion-B angle. Cone beam computed tomography was used for three-dimensional reconstruction of the maxillofacial region and airway. The hyoid position and the tongue, airway and oral cavity volumes were evaluated. Upper airway ventilation status was calculated using computational fluid dynamics. The groups were compared using analysis of variance and Kruskal-Wallis tests; relationships among the parameters were assessed using Pearson's and Spearman's rank correlation tests. The tongue volume was larger in Class-III patients (50.63 cm ) than in Class-I patients (44.24 cm ; P < 0.05). The hyoid position was lower (49.44 cm), and anatomical balance (AB; tongue volume/oral cavity volume; 85.06%) was greater in Class-II patients than in Class-I patients (46.06 cm, 80.57%, respectively; P < 0.05 for both). The hyoid height showed a positive correlation with AB (r = 0.614; P < 0.001). Children with Class-III malocclusion have large tongue volumes and small AB; the reverse is true for children with Class-II malocclusion. The hyoid position is closely associated with AB in children with malocclusion.
(キーワード): 子ども (children) / Cone-Beam Computed Tomography / 顔 (face) / 女性 (female) / Humans / Hyoid Bone / Imaging, Three-Dimensional / 男性 (male) / Malocclusion, Angle Class I / Malocclusion, Angle Class II / Malocclusion, Angle Class III / Maxilla / Nasopharynx / Retrospective Studies / Tongue
(出版サイトへのリンク): ● Publication site (DOI): 10.1111/ocr.12251
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30421852; ● Summary page in Scopus @ Elsevier: 2-s2.0-85057995782

(DOI: 10.1111/ocr.12251, PubMed: 30421852, Elsevier: Scopus) Tomonori Iwasaki, Hokuto Suga, Ayaka Minami-Yanagisawa, Makiko Hashiguchi-Sato, Hideo Sato, Yuushi Yamamoto, Yoshito Shirazawa, Toshiya Tsujii, Ryuzo Kanomi and Youichi Yamasaki :
Upper airway in children with unilateral cleft lip and palate evaluated with computational fluid dynamics.,
American Journal of Orthodontics and Dentofacial Orthopedics (AJO-DO), Vol.156, No.2, 257-265, 2019.

(要約): Children with unilateral cleft lip and palate (UCLP) exhibit snoring and mouth breathing. They are also reported to show obstructive sleep apnea syndrome. However, their upper airway ventilation condition is not clearly understood. Therefore, this study was performed to evaluate upper airway ventilation condition in children with UCLP with the use of computational fluid dynamics. Twenty-one children (12 boys, 9 girls; mean age 9.1 years) with UCLP and 25 children (13 boys, 12 girls; mean age 9.2 years) without UCLP who required orthodontic treatment underwent cone-beam computed tomography (CBCT). Nasal resistance and upper airway ventilation condition were evaluated with the use of computational fluid dynamics from CBCT data. The groups were compared with the use of Mann-Whitney U tests and Student t tests. Nasal resistance of the UCLP group (0.97 Pa/cm/s) was significantly higher than that of the control group (0.26 Pa/cm/s; P < 0.001). Maximal pressure of the upper airway (335.02 Pa) was significantly higher in the UCLP group than in the control group (67.57 Pa; P < 0.001). Pharyngeal airway (from choanae to base of epiglottis) pressure in the UCLP group (140.46 Pa) was significantly higher than in the control group (15.92 Pa; P < 0.02). Upper airway obstruction in children with UCLP resulted from both nasal and pharyngeal airway effects.
(キーワード): Adenoids / Anatomic Landmarks / 子ども (children) / Cleft Lip / Cleft Palate / Cone-Beam Computed Tomography / Epiglottis / 女性 (female) / Humans / Hydrodynamics / Hyoid Bone / Imaging, Three-Dimensional / Larynx / Malocclusion, Angle Class I / Nasopharynx / Nose / 呼吸 (respiration) / Sleep Apnea, Obstructive
(徳島大学機関リポジトリ): ● Metadata: 115788
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.ajodo.2018.09.013
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31375236; ● Summary page in Scopus @ Elsevier: 2-s2.0-85069847699

(徳島大学機関リポジトリ: 115788, DOI: 10.1016/j.ajodo.2018.09.013, PubMed: 31375236, Elsevier: Scopus) Tomonori Iwasaki, Ayaka Yanagisawa-Minami, Hokuto Suga, Yoshito Shirazawa, Toshiya Tsujii, Yuushi Yamamoto, Yuusuke Ban, Makiko Sato-Hashiguchi, Hideo Sato, Ryuzo Kanomi and Youichi Yamasaki :
Rapid maxillary expansion effects of nasal airway in children with cleft lip and palate using computational fluid dynamics.,
Orthodontics & Craniofacial Research, Vol.22, No.3, 201-207, 2019.

(要約): Rapid maxillary expansion (RME) improves nasal airway ventilation in non-cleft palate children. Children with unilateral cleft lip and palate (UCLP) may have nasal obstruction and experience an increased risk of obstructive sleep apnoea. The effect of RME in UCLP children is unclear. This retrospective study evaluated RME-induced changes in ventilation parameters in children with UCLP using computational fluid dynamics. Nineteen patients (10 boys, mean age 10.7 years) who required RME had cone-beam computed tomography images taken before and after RME. Twenty control participants (11 boys, mean age 11.1 years) received regular orthodontic treatment. Nasal airway ventilation parameters (air pressure, air velocity and airflow rate) were analysed via computational fluid dynamics, and nasal cross-sectional area (CSA) was measured. Maximum pressure, velocity and nasal resistance were significantly reduced by RME in the UCLP group. Air flow rate and CSA on the cleft side significantly were increased by RME in the UCLP group. In children with UCLP, increasing the quantity of airflow and CSA on the cleft side by RME substantially improved nasal ventilation.
(キーワード): 子ども (children) / Cleft Lip / Humans / Hydrodynamics / 男性 (male) / Palatal Expansion Technique / Retrospective Studies
(出版サイトへのリンク): ● Publication site (DOI): 10.1111/ocr.12311
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30912603; ● Summary page in Scopus @ Elsevier: 2-s2.0-85064624943

(DOI: 10.1111/ocr.12311, PubMed: 30912603, Elsevier: Scopus) Hokuto Suga, Tomonori Iwasaki, Katsuaki Mishima, Hiroyuki Nakano, Yoshiya Ueyama and Youichi Yamasaki :
Evaluation of the effect of oral appliance treatment on upper-airway ventilation conditions in obstructive sleep apnea using computational fluid dynamics.,
Cranio, 1-9, 2019.

(要約): To evaluate the effect of oral appliance (OA) treatment on upper-airway ventilation conditions in patients with obstructive sleep apnea (OSA) using computational fluid dynamics (CFD). Fifteen patients received OA treatment and underwent polysomnography (PSG) and computed tomography (CT). CT data were used to reconstruct three-dimensional models of nasal and pharyngeal airways. Airflow velocity and airway pressure measurements at inspiration were simulated using CFD. The apnea-hypopnea index (AHI) improved from 23.1 to 10.1 events/h after OA treatment. On CFD analysis, airflow velocity decreased at the retropalatal and epiglottis-tip levels, while airway pressure decreased at the retropalatal, uvular- and epiglottis-tip levels. The AHI of patients with OSA before OA treatment was correlated with airway pressure at the epiglottis-tip level. Treatment with OA improved the ventilation conditions of the pharyngeal airway and AHI. Results of CFD analysis of airway pressure and airflow velocity helped determine the severity and ventilatory impairment site of OSA, respectively.
(徳島大学機関リポジトリ): ● Metadata: 115756
(出版サイトへのリンク): ● Publication site (DOI): 10.1080/08869634.2019.1596554
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30931819; ● Summary page in Scopus @ Elsevier: 2-s2.0-85063602484

(徳島大学機関リポジトリ: 115756, DOI: 10.1080/08869634.2019.1596554, PubMed: 30931819, Elsevier: Scopus) Keika Mukaihara, Maiko Hasegawa-Moriyama, Tomonori Iwasaki, Youichi Yamasaki and Yuichi Kanmura :
Evaluation of the pharyngeal airway using computational fluid dynamics in patients with acromegaly.,
Laryngoscope Investigative Otolaryngology, Vol.3, No.2, 133-138, 2018.

(要約): Perioperative airway management may be particularly challenging in patients with acromegaly undergoing trans-sphenoidal pituitary surgery (TSS). Management for airway obstruction is required prior to pituitary surgery to minimize perioperative hypoxia. The purpose of this retrospective study was to evaluate airway obstruction by simulation of computational fluid dynamics (CFD) using computed tomography (CT) images in patients who had undergone TSS. CT images of the nasopharyngeal airways of patients with acromegaly (n = 5) or nonfunctional pituitary adenoma (n = 6) undergoing TSS from April 2012 to January 2017 were used to construct these airways in three dimensions. Estimated airflow pressure and velocity in the retropalatal airway (RA), oropharyngeal airway (OA), and hypopharyngeal airway (HA) were simulated using CFD. Estimated pharyngeal airflow pressure in the HA, OA, and RA was significantly greater in patients with acromegaly than in those with nonfunctional pituitary adenomas whereas the estimated pharyngeal airflow velocity was significantly impaired only in the RA of patients with acromegaly. Minimum postoperative SpO both within 3 hours and from 3 to 12 hours after the end of anesthesia was significantly lower in the patients with acromegaly. Additionally, estimated volume of tongue and pharyngeal airflow pressure in the HA, OA, and RA correlated with minimum postoperative SpO. Pharyngeal airflow pressure estimated from CT images is high in patients with acromegaly, and these values correlate with postoperative minimum values for SpO. Preoperative evaluation of CT images by CFD can predict difficulty in airway management and perioperative hypoxia. 4.
(徳島大学機関リポジトリ): ● Metadata: 115757
(出版サイトへのリンク): ● Publication site (DOI): 10.1002/lio2.151
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29721547; ● Search Scopus @ Elsevier (PMID): 29721547; ● Search Scopus @ Elsevier (DOI): 10.1002/lio2.151

(徳島大学機関リポジトリ: 115757, DOI: 10.1002/lio2.151, PubMed: 29721547) 宮川尚之, 岩﨑智憲, 菅北斗, 伴祐輔, 山﨑要一 :
小児の口呼吸が睡眠ならびに日中の行動におよぼす影響のアンケート調査,
小児歯科学雑誌, Vol.56, No.1, 19-25, 2018年.

(要約): 本研究は小児の口呼吸が睡眠や日中の行動におよぼす影響を明らかにすることを目的に，アンケート調査を行った．2017年7月と8月に鹿児島県内の歯科医院を受診した特記すべき既往のない3歳から12歳までの小児165名(男児73名，女児92名，平均年齢8.3±2.3歳)を対象とした．睡眠中にいびきをかく頻度は27.3%，息が止まる頻度は2.4%だった．口呼吸の頻度は16.4%で，口呼吸を認める場合，胸郭陥凹，開口，鼾，起床困難，風邪，鼻水，嚥下困難，日中傾眠，注意欠陥，多動を示し，小児の口呼吸は睡眠や日常生活に大きな影響をおよぼすことが示された．以上のことから，われわれ小児歯科医が小児の口腔を通した健全な成長発達に貢献するためには，齲蝕をはじめとする硬組織疾患，顎顔面歯列咬合異常や摂食・咀嚼・嚥下障害などの形態的・機能的な問題点に加えて，呼吸に関しても十分な注意を払う必要があることが示された．
(キーワード): 小児 (infant) / 口呼吸 / 睡眠 (sleep) / 日中の行動 / アンケート (enquête)
(徳島大学機関リポジトリ): ● Metadata: 115796
(出版サイトへのリンク): ● Publication site (DOI): 10.11411/jspd.56.1_19
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390282763100673536; ● Search Scopus @ Elsevier (DOI): 10.11411/jspd.56.1_19

(徳島大学機関リポジトリ: 115796, DOI: 10.11411/jspd.56.1_19, CiNii: 1390282763100673536) Mie Kurosawa, Issei Saitoh, Yoko Iwase, Emi Inada, Yukiko Nogami, Nozomi Murakami, Shinji Shibasaki, Tomoya Murakami, Tomonori Iwasaki, Kazunari Matsueda, Yuki Nakamura, Youichi Yamasaki and Haruaki Hayasaki :
Comparison of dynamic occlusal contacts during chewing between working and balancing sides,
Dental, Oral, and Craniofacial Research, Vol.4, No.2, 1-7, 2017.

(徳島大学機関リポジトリ): ● Metadata: 115759
(出版サイトへのリンク): ● Publication site (DOI): 10.15761/DOCR.1000244
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.15761/DOCR.1000244

(徳島大学機関リポジトリ: 115759, DOI: 10.15761/DOCR.1000244) Tomonori Iwasaki, Hideo Sato, Hokuto Suga, Yoshihiko Takemoto, Emi Inada, Issei Saitoh, Eriko Kakuno, Ryuzo Kanomi and Youichi Yamasaki :
Relationships among nasal resistance, adenoids, tonsils, and tongue posture and maxillofacial form in Class II and Class III children.,
American Journal of Orthodontics and Dentofacial Orthopedics (AJO-DO), Vol.151, No.5, 929-940, 2017.

(要約): The purpose of this study was to clarify the relationships between upper airway factors (nasal resistance, adenoids, tonsils, and tongue posture) and maxillofacial forms in Class II and III children. Sixty-four subjects (mean age, 9.3 years) with malocclusion were divided into Class II and Class III groups by ANB angles. Nasal resistance was calculated using computational fluid dynamics from cone-beam computed tomography data. Adenoids, tonsils, and tongue posture were evaluated in the cone-beam computed tomography images. The groups were compared using Mann-Whitney U tests and Student t tests. The Spearman rank correlations test assessed the relationships between the upper airway factors and maxillofacial form. Nasal resistance of the Class II group was significantly larger than that of the Class III group (P = 0.005). Nasal resistance of the Class II group was significantly correlated with inferior tongue posture (P <0.001) and negatively correlated with intermolar width (P = 0.028). Tonsil size of the Class III group was significantly correlated with anterior tongue posture (P <0.001) and mandibular incisor anterior position (P = 0.007). Anterior tongue posture of the Class III group was significantly correlated with mandibular protrusion. The relationships of upper airway factors differ between Class II and Class III children.
(キーワード): Adenoids / Airway Resistance / 子ども (children) / Cone-Beam Computed Tomography / 女性 (female) / Humans / 男性 (male) / Malocclusion, Angle Class II / Malocclusion, Angle Class III / Nasal Cavity / Palatine Tonsil / Pathology, Oral / Retrospective Studies / Tongue
(徳島大学機関リポジトリ): ● Metadata: 116136
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.ajodo.2016.10.027
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28457271; ● Summary page in Scopus @ Elsevier: 2-s2.0-85018259591

(徳島大学機関リポジトリ: 116136, DOI: 10.1016/j.ajodo.2016.10.027, PubMed: 28457271, Elsevier: Scopus) Tomonori Iwasaki, Hideo Sato, Hokuto Suga, Yoshihiko Takemoto, Emi Inada, Issei Saitoh, Eriko Kakuno, Ryozo Kanomi and Youichi Yamasaki :
Influence of pharyngeal airway respiration pressure on Class II mandibular retrusion in children: A computational fluid dynamics study of inspiration and expiration.,
Orthodontics & Craniofacial Research, Vol.20, No.2, 95-101, 2017.

(要約): To examine the influence of negative pressure of the pharyngeal airway on mandibular retraction during inspiration in children with nasal obstruction using the computational fluid dynamics (CFD) method. Sixty-two children were divided into Classes I, II (mandibular retrusion) and III (mandibular protrusion) malocclusion groups. Cone-beam computed tomography data were used to reconstruct three-dimensional shapes of the nasal and pharyngeal airways. Airflow pressure was simulated using CFD to calculate nasal resistance and pharyngeal airway pressure during inspiration and expiration. Nasal resistance of the Class II group was significantly higher than that of the other two groups, and oropharyngeal airway inspiration pressure in the Class II (-247.64 Pa) group was larger than that in the Class I (-43.51 Pa) and Class III (-31.81 Pa) groups (P<.001). The oropharyngeal airway inspiration-expiration pressure difference in the Class II (-27.38 Pa) group was larger than that in the Class I (-5.17 Pa) and Class III (0.68 Pa) groups (P=.006). Large negative inspiratory pharyngeal airway pressure due to nasal obstruction in children with Class II malocclusion may be related to their retrognathia.
(キーワード): Airway Resistance / 子ども (children) / Cone-Beam Computed Tomography / 女性 (female) / Humans / 男性 (male) / Malocclusion, Angle Class II / Nasal Obstruction / Pharynx / 圧力 (pressure)
(出版サイトへのリンク): ● Publication site (DOI): 10.1111/ocr.12145
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28414873; ● Summary page in Scopus @ Elsevier: 2-s2.0-85017552820

(DOI: 10.1111/ocr.12145, PubMed: 28414873, Elsevier: Scopus) Tomonori Iwasaki, Hideo Sato, Hokuto Suga, Ayaka Minami, Yuushi Yamamoto, Yoshihiko Takemoto, Emi Inada, Issei Saitoh, Eriko Kakuno, Ryuzo Kanomi and Youichi Yamasaki :
Herbst appliance effects on pharyngeal airway ventilation evaluated using computational fluid dynamics.,
The Angle Orthodontist, Vol.87, No.3, 397-403, 2017.

(要約): To evaluate the effect of a Herbst appliance on ventilation of the pharyngeal airway (PA) using computational fluid dynamics (CFD). Twenty-one Class II patients (10 boys; mean age, 11.7 years) who required Herbst therapy with edgewise treatment underwent cone-beam computed tomography (CBCT) before and after treatment. Nineteen Class I control patients (8 boys; mean age, 11.9 years) received edgewise treatment alone. The pressure and velocity of the PA were compared between the groups using CFD based on three-dimensional CBCT images of the PA. The change in oropharyngeal airway velocity in the Herbst group (1.95 m/s) was significantly larger than that in the control group (0.67 m/s). Similarly, the decrease in laryngopharyngeal airway velocity in the Herbst group (1.37 m/s) was significantly larger than that in the control group (0.57 m/s). The Herbst appliance improves ventilation of the oropharyngeal and laryngopharyngeal airways. These results may provide a useful assessment of obstructive sleep apnea treatment during growth.
(キーワード): 子ども (children) / Computational Biology / Cone-Beam Computed Tomography / 女性 (female) / Humans / Hydrodynamics / 男性 (male) / Malocclusion, Angle Class II / Orthodontic Appliances, Functional / Pharynx / 呼吸 (respiration) / Treatment Outcome
(徳島大学機関リポジトリ): ● Metadata: 115799
(出版サイトへのリンク): ● Publication site (DOI): 10.2319/080616-603.1
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28121164; ● Summary page in Scopus @ Elsevier: 2-s2.0-85019859164

(徳島大学機関リポジトリ: 115799, DOI: 10.2319/080616-603.1, PubMed: 28121164, Elsevier: Scopus) Ken Morizono, Yoshihiko Takemoto, Emi Inada, Daisuke Murakami, Issei Saitoh, Hideo Sato, Tomonori Iwasaki and Youichi Yamasaki :
Simultaneous Evaluation of Three-Dimensional Lip Kinetics and Tongue Pressure during Swallowing,
International Journal of Dentistry and Oral Health, Vol.2, No.2, 2016.

(要約): Objectives: The purpose of this study was to evaluate the amount of lip movement and simultaneous tongue pressure changes on an artificial palatal plate during swallowing. Methods: Subjects were 9 healthy males (25.4 ± 2.1 years of age). Three-dimensional lip movement was measured by a wireless optoelectronic system, and tongue pressure was simultaneously recorded by a sensor sheet attached to the incisive papilla of an artificial palatal plate. Reflective markers were attached to the right and left corners of the mouth to measure the distance between them. All subjects were instructed to swallow 5 mL and 20 mL samples of water at will. The maximum change of distance between the corners of mouth, the maximum tongue pressure, and the time interval between the two maxima (lip-tongue interval) were calculated. Wilcoxon's test was used to detect significant differences in these measurements between the two volumes. Results: Maximum tongue pressure did not differ significantly between swallowed volumes. The maximum change of distance between the corners of mouth was larger and the lip-tongue interval was significantly shorter with the larger volume. Conclusions: We suggest that swallowing a larger volume is accomplished by larger lip movement rather than larger tongue movement. These results indicate that lip movement during swallowing can be evaluated objectively.
(キーワード): Swallowing / Lip motion / Tongue pressure / Motion capture / Simultaneous evaluation
(徳島大学機関リポジトリ): ● Metadata: 115755
(出版サイトへのリンク): ● Publication site (DOI): 10.16966/2378-7090.169
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1050005822261407616; ● Search Scopus @ Elsevier (DOI): 10.16966/2378-7090.169

(徳島大学機関リポジトリ: 115755, DOI: 10.16966/2378-7090.169, CiNii: 1050005822261407616) Stanley Yung-Chuan Liu, Leh-Kiong Huon, Tomonori Iwasaki, Audrey Yoon, Robert Riley, Nelson Powell, Carlos Torre and Robson Capasso :
Efficacy of Maxillomandibular Advancement Examined with Drug-Induced Sleep Endoscopy and Computational Fluid Dynamics Airflow Modeling.,
Otolaryngology--Head and Neck Surgery, Vol.154, No.1, 189-195, 2016.

(要約): To use drug-induced sedation endoscopy (DISE) and computational fluid dynamics (CFD) modeling to study dynamic airway and airflow changes after maxillomandibular advancement (MMA), and how the changes correlate with surgical success based on polysomnography parameters. Retrospective cohort study. University medical center. DISE was rated with the VOTE (velum, oropharynx, tongue, epiglottis) classification, and CFD was used to model airflow velocity and negative pressure exerted on pharyngeal wall. Changes in VOTE score by site and CFD measurements were correlated with perioperative polysomnography outcomes of apnea-hypopnea index (AHI), apnea index (AI), oxygenation desaturation index (ODI), and lowest oxygen saturation. After MMA, 20 subjects (17 males, 3 females) with a mean age of 44 ± 12 years and body mass index of 27.4 ± 4.6 kg/m(2) showed mean decreases in AHI (53.6 ± 26.6 to 9.5 ± 7.4 events/h) and ODI (38.7 ± 30.3 to 8.1 ± 9.2 events/h; P < .001). Improvement in lateral pharyngeal wall collapse during DISE based on VOTE score correlated with the most decrease in AHI (60.0 ± 25.6 to 7.5 ± 3.4 events/h) and ODI (46.7 ± 29.8 to 5.3 ± 2 events/h; P = .002). CFD modeling showed significant positive Pearson correlations between reduction of retropalatal airflow velocity and AHI (r = 0.617, P = .04) and ODI (r = 0.773, P = .005). AHI and ODI improvement after MMA is best correlated with (1) decreased retropalatal airflow velocity modeled by CFD and (2) increased lateral pharyngeal wall stability based on VOTE scoring from DISE.
(キーワード): Adolescent / Adult / Cohort Studies / Endoscopy / 女性 (female) / Humans / Hydrodynamics / 男性 (male) / Mandibular Advancement / Middle Aged / Models, Theoretical / Polysomnography / Retrospective Studies / 睡眠 (sleep) / Treatment Outcome / Young Adult
(出版サイトへのリンク): ● Publication site (DOI): 10.1177/0194599815611603
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26740522; ● Summary page in Scopus @ Elsevier: 2-s2.0-84954177550

(DOI: 10.1177/0194599815611603, PubMed: 26740522, Elsevier: Scopus) Emi Inada, Issei Saitoh, Yong Yu, Daisuke Tomiyama, Daisuke Murakami, Yoshihiko Takemoto, Ken Morizono, Tomonori Iwasaki, Yoko Iwase and Youichi Yamasaki :
Quantitative evaluation of toothbrush and arm-joint motion during tooth brushing.,
Clinical Oral Investigations, Vol.19, No.6, 1451-1462, 2015.

(要約): It is very difficult for dental professionals to objectively assess tooth brushing skill of patients, because an obvious index to assess the brushing motion of patients has not been established. The purpose of this study was to quantitatively evaluate toothbrush and arm-joint motion during tooth brushing. Tooth brushing motion, performed by dental hygienists for 15 s, was captured using a motion-capture system that continuously calculates the three-dimensional coordinates of object's motion relative to the floor. The dental hygienists performed the tooth brushing on the buccal and palatal sides of their right and left upper molars. The frequencies and power spectra of toothbrush motion and joint angles of the shoulder, elbow, and wrist were calculated and analyzed statistically. The frequency of toothbrush motion was higher on the left side (both buccal and palatal areas) than on the right side. There were no significant differences among joint angle frequencies within each brushing area. The inter- and intra-individual variations of the power spectrum of the elbow flexion angle when brushing were smaller than for any of the other angles. This study quantitatively confirmed that dental hygienists have individual distinctive rhythms during tooth brushing. All arm joints moved synchronously during brushing, and tooth brushing motion was controlled by coordinated movement of the joints. The elbow generated an individual's frequency through a stabilizing movement. The shoulder and wrist control the hand motion, and the elbow generates the cyclic rhythm during tooth brushing.
(キーワード): Adult / Arm / Dental Hygienists / 女性 (female) / Humans / Imaging, Three-Dimensional / 男性 (male) / Movement / Toothbrushing
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s00784-014-1367-2
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25467235; ● Search Scopus @ Elsevier (PMID): 25467235; ● Search Scopus @ Elsevier (DOI): 10.1007/s00784-014-1367-2

(DOI: 10.1007/s00784-014-1367-2, PubMed: 25467235) Tomonori Iwasaki, Yoshihiko Takemoto, Emi Inada, Hideo Sato, Issei Saitoh, Eriko Kakuno, Ryuzo Kanomi and Youichi Yamasaki :
Three-dimensional cone-beam computed tomography analysis of enlargement of the pharyngeal airway by the Herbst appliance.,
American Journal of Orthodontics and Dentofacial Orthopedics (AJO-DO), Vol.146, No.6, 776-785, 2014.

(要約): Pharyngeal airway size is increasingly recognized as an important factor in obstructive sleep apnea. However, few studies have examined the changes of pharyngeal airway form after dental procedures for treating obstructive sleep apnea during growth. The purpose of this study was to evaluate the effect of the Herbst appliance on the 3-dimensional form of the pharyngeal airway using cone-beam computed tomography. Twenty-four Class II subjects (ANB, ≥5°; 11 boys; mean age, 11.6 years) who required Herbst therapy with edgewise treatment had cone-beam computed tomography images taken before and after Herbst treatment. Twenty Class I control subjects (9 boys; mean age, 11.5 years) received edgewise treatment only. The volume, depth, and width of the pharyngeal airway were compared between the groups using measurements from 3-dimensional cone-beam computed tomography images of the entire pharyngeal airway. The increase of the oropharyngeal airway volume in the Herbst group (5000.2 mm(3)) was significantly greater than that of the control group (2451.6 mm(3)). Similarly, the increase of the laryngopharyngeal airway volume in the Herbst group (1941.8 mm(3)) was significantly greater than that of the control group (1060.1 mm(3)). The Herbst appliance enlarges the oropharyngeal and laryngopharyngeal airways. These results may provide a useful assessment of obstructive sleep apnea treatment during growth.
(キーワード): Adolescent / Anatomic Landmarks / Anatomy, Cross-Sectional / Case-Control Studies / Cephalometry / 子ども (children) / Cone-Beam Computed Tomography / 女性 (female) / Follow-Up Studies / Humans / Image Processing, Computer-Assisted / Imaging, Three-Dimensional / Larynx / Longitudinal Studies / 男性 (male) / Malocclusion, Angle Class II / Mandible / Maxilla / Nasal Bone / Oropharynx / Orthodontic Appliances / Orthodontic Appliances, Functional / Pharynx / Retrospective Studies / Sella Turcica
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.ajodo.2014.08.017
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25432259; ● Summary page in Scopus @ Elsevier: 2-s2.0-84922151815

(DOI: 10.1016/j.ajodo.2014.08.017, PubMed: 25432259, Elsevier: Scopus) Daisuke Murakami, Emi Inada, Issei Saitoh, Yoshihiko Takemoto, Ken Morizono, Naoko Kubota, Tomonori Iwasaki, Takeshi Oku and Youichi Yamasaki :
Morphological differences of facial soft tissue contours from child to adult of Japanese males: a three-dimensional cross-sectional study.,
Archives of Oral Biology, Vol.59, No.12, 1391-1399, 2014.

(要約): To evaluate morphological differences of the facial soft tissue surface between male Japanese adults and children. 20 adult Japanese males (average age 28 years) and 20 Japanese boys (average age 5.5 years) with normal occlusion were selected for this study. The images of the subjects' facial surface were obtained with a 3-D laser scanner. To evaluate the three-dimensional morphological differences of the facial soft tissue, we transformed the coordinates of 16 facial landmarks to a new reference plane and compared the adults' and children's facial form drawn to the same scale in the same coordinate system. The morphological difference ratio of the lower facial area was higher than in the upper facial area, and the nose and lower face changed more forward than downward. The morphological difference ratio of the mid face width was smaller than other areas. Our study suggests that the morphological facial soft tissue differences between Japanese adults and children are more forward and downward than laterally, manifesting in a facial form of adults that is deeper and narrow.
(キーワード): Adult / Child, Preschool / Cross-Sectional Studies / 顔 (face) / Humans / Imaging, Three-Dimensional / 日本 (Japan) / Lasers / 男性 (male) / Maxillofacial Development
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.archoralbio.2014.08.004
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25214309; ● Summary page in Scopus @ Elsevier: 2-s2.0-84908452176

(DOI: 10.1016/j.archoralbio.2014.08.004, PubMed: 25214309, Elsevier: Scopus) Haruaki Hayasaki, Issei Saitoh, Kuniko Nakakura-Ohshima, Mika Hanasaki, Yukiko Nogami, Tsutomu Nakajima, Emi Inada, Tomonori Iwasaki, Yoko Iwase, Tadashi Sawami, Katsushige Kawasaki, Nozomi Murakami, Tomoya Murakami, Mie Kurosawa, Masami Kimi, Akiko Kagoshima, Miki Soda and Youich Yamasaki :
Tooth brushing for oral prophylaxis,
Japanese Dental Science Review, Vol.50, No.3, 69-77, 2014.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jdsr.2014.04.001
(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-84904294254

(DOI: 10.1016/j.jdsr.2014.04.001, Elsevier: Scopus) Emi Inada, Issei Saitoh, Daisuke Murakami, Naoko Kubota, Yoshihiko Takemoto, 岩﨑智憲, Kuniko Nakakura-Ohshima, Haruaki Hayasaki, Youichi Yamasaki :
Relationship between nasal and skeletal landmarks on lateral cephalograms of adults,
The Australian Journal of Forensic Sciences, Vol.46, No.3, 339-347, 2014年.

(出版サイトへのリンク): ● Publication site (DOI): 10.1080/00450618.2013.877079
(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-84904761450

(DOI: 10.1080/00450618.2013.877079, Elsevier: Scopus) Tomonori Iwasaki, Yoshihiko Takemoto, Emi Inada, Hideo Sato, Hokuto Suga, Issei Saitoh, Eriko Kakuno, Ryuzo Kanomi and Youichi Yamasaki :
The effect of rapid maxillary expansion on pharyngeal airway pressure during inspiration evaluated using computational fluid dynamics.,
International Journal of Pediatric Otorhinolaryngology, Vol.78, No.8, 1258-1264, 2014.

(要約): Recent evidence suggests that rapid maxillary expansion (RME) is an effective treatment of obstructive sleep apnea syndrome (OSAS) in children with maxillary constriction. Nonetheless, the effect of RME on pharyngeal airway pressure during inspiration is not clear. The purpose of this retrospective study was to evaluate changes induced by the RME in ventilation conditions using computational fluid dynamics. Twenty-five subjects (14 boys, 11 girls; mean age 9.7 years) who required RME had cone-beam computed tomography (CBCT) images taken before and after the RME. The CBCT data were used to reconstruct 3-dimensional shapes of nasal and pharyngeal airways. Measurement of airflow pressure was simulated using computational fluid dynamics for calculating nasal resistance during exhalation. This value was used to assess maximal negative pressure in the pharyngeal airway during inspiration. Nasal resistance after RME, 0.137 Pa/(cm(3)/s), was significantly lower than that before RME, 0.496 Pa/(cm(3)/s), and the maximal negative pressure in the pharyngeal airway during inspiration was smaller after RME (-48.66 Pa) than before (-124.96 Pa). Pharyngeal airway pressure during inspiration is decreased with the reduction of nasal resistance by the RME. This mechanism may contribute to the alleviation of OSAS in children.
(キーワード): Child / Computational Biology / Cone-Beam Computed Tomography / Exhalation / 女性 (female) / Humans / Hydrodynamics / Imaging, Three-Dimensional / Inhalation / Longitudinal Studies / 男性 (male) / Nasal Cavity / Palatal Expansion Technique / Pharynx / Pulmonary Ventilation / Retrospective Studies / Sleep Apnea, Obstructive
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.ijporl.2014.05.004
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24865805; ● Summary page in Scopus @ Elsevier: 2-s2.0-84904056045

(DOI: 10.1016/j.ijporl.2014.05.004, PubMed: 24865805, Elsevier: Scopus) Chiaki Yamada-Ito, Issei Saitoh, Kohtaro Yashiro, Emi Inada, Tomoaki Maruyama, Kenji Takada, Tomonori Iwasaki, Haruaki Hayasaki and Youichi Yamasaki :
Smoothness of molar movement during gum chewing in children with primary dentition.,
Cranio, Vol.31, No.4, 260-269, 2013.

(要約): The purpose of this study was to test the null hypothesis that molar movement during gum chewing in children with primary dentition is as smooth as in adults. Twenty-two healthy children with primary dentition and 23 healthy adult females participated in this study. Mandibular movement during gum chewing was recorded using an optoelectronic analysis system with six degrees-of-freedom at 100 Hz, and 10 cycles were selected for analysis. Normalized jerk cost (NJC) at the incisors and working and balancing molars were calculated in each phase (i.e., opening, closing and occlusal level phases) for each chewing cycle. The NJC of the working side molar in children was larger than in adults in both the opening and occlusal phases. Inter-individual variances of the NJC in each phase in children and adults were smaller than corresponding intra-individual variances, except for the NJC during the occlusal phase of adults for the working and balancing side molars. The inter- and intra-individual variances of the NJC during the closing phase were the smallest in each phase for both children and adults. This indicates that the jaw movements of children with primary dentition are more variable, less smooth, and faster than that of adults.
(キーワード): Chewing Gum / Child, Preschool / 女性 (female) / Humans / Linear Models / 男性 (male) / Mandible / Mastication / Molar / Movement / Tooth, Deciduous / Young Adult
(出版サイトへのリンク): ● Publication site (DOI): 10.1179/crn.2013.31.4.003
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24308099; ● Summary page in Scopus @ Elsevier: 2-s2.0-84888081765

(DOI: 10.1179/crn.2013.31.4.003, PubMed: 24308099, Elsevier: Scopus) Tomonori Iwasaki, Issei Saitoh, Yoshihiko Takemoto, Emi Inada, Eriko Kakuno, Ryuzo Kanomi, Haruaki Hayasaki and Youichi Yamasaki :
Tongue posture improvement and pharyngeal airway enlargement as secondary effects of rapid maxillary expansion: a cone-beam computed tomography study.,
American Journal of Orthodontics and Dentofacial Orthopedics (AJO-DO), Vol.143, No.2, 235-245, 2013.

(要約): Rapid maxillary expansion (RME) is known to improve nasal airway ventilation. Recent evidence suggests that RME is an effective treatment for obstructive sleep apnea in children with maxillary constriction. However, the effect of RME on tongue posture and pharyngeal airway volume in children with nasal airway obstruction is not clear. In this study, we evaluated these effects using cone-beam computed tomography. Twenty-eight treatment subjects (mean age 9.96 ± 1.21 years) who required RME treatment had cone-beam computed tomography images taken before and after RME. Twenty control subjects (mean age 9.68 ± 1.02 years) received regular orthodontic treatment. Nasal airway ventilation was analyzed by using computational fluid dynamics, and intraoral airway (the low tongue space between tongue and palate) and pharyngeal airway volumes were measured. Intraoral airway volume decreased significantly in the RME group from 1212.9 ± 1370.9 mm(3) before RME to 279.7 ± 472.0 mm(3) after RME. Nasal airway ventilation was significantly correlated with intraoral airway volume. The increase of pharyngeal airway volume in the control group (1226.3 ± 1782.5 mm(3)) was only 41% that of the RME group (3015.4 ± 1297.6 mm(3)). In children with nasal obstruction, RME not only reduces nasal obstruction but also raises tongue posture and enlarges the pharyngeal airway.
(キーワード): Adolescent / Airway Obstruction / Airway Resistance / Anatomy, Cross-Sectional / Case-Control Studies / Cephalometry / 子ども (children) / Cone-Beam Computed Tomography / 女性 (female) / Humans / Hydrodynamics / Longitudinal Studies / 男性 (male) / Matched-Pair Analysis / Maxilla / Nasal Cavity / Orthodontics, Corrective / Palatal Expansion Technique / Pharynx / Reference Values / Retrospective Studies / Tongue Habits / Treatment Outcome
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.ajodo.2012.09.014
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23374931; ● Summary page in Scopus @ Elsevier: 2-s2.0-84873128781

(DOI: 10.1016/j.ajodo.2012.09.014, PubMed: 23374931, Elsevier: Scopus) Tomonori Iwasaki, Issei Saitoh, Yoshihiko Takemoto, Emi Inada, Ryuzo Kanomi, Haruaki Hayasaki and Youichi Yamasaki :
Improvement of nasal airway ventilation after rapid maxillary expansion evaluated with computational fluid dynamics.,
American Journal of Orthodontics and Dentofacial Orthopedics (AJO-DO), Vol.141, No.3, 269-278, 2012.

(要約): Rapid maxillary expansion is known to improve nasal airway ventilation. However, it is difficult to precisely evaluate this improvement with conventional methods. The purpose of this longitudinal study was to use computational fluid dynamics to estimate the effect of rapid maxillary expansion. Twenty-three subjects (9 boys, 14 girls; mean ages, 9.74 ± 1.29 years before rapid maxillary expansion and 10.87 ± 1.18 years after rapid maxillary expansion) who required rapid maxillary expansion as part of their orthodontic treatment had cone-beam computed tomography images taken before and after rapid maxillary expansion. The computed tomography data were used to reconstruct the 3-dimensional shape of the nasal cavity. Two measures of nasal airflow function (pressure and velocity) were simulated by using computational fluid dynamics. The pressure after rapid maxillary expansion (80.55 Pa) was significantly lower than before rapid maxillary expansion (147.70 Pa), and the velocity after rapid maxillary expansion (9.63 m/sec) was slower than before rapid maxillary expansion (13.46 m/sec). Improvement of nasal airway ventilation by rapid maxillary expansion was detected by computational fluid dynamics.
(キーワード): 子ども (children) / Computational Biology / Cone-Beam Computed Tomography / Dental Arch / Exhalation / 女性 (female) / Follow-Up Studies / Humans / Hydrodynamics / Image Processing, Computer-Assisted / Imaging, Three-Dimensional / Inhalation / Longitudinal Studies / 男性 (male) / Maxilla / Nasal Cavity / Nasal Obstruction / Orthodontics, Corrective / Palatal Expansion Technique / 圧力 (pressure) / Pulmonary Ventilation
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.ajodo.2011.08.025
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22381487; ● Summary page in Scopus @ Elsevier: 2-s2.0-84857772183

(DOI: 10.1016/j.ajodo.2011.08.025, PubMed: 22381487, Elsevier: Scopus) Emi Inada, Issei Saitoh, Kuniko Nakakura-Ohshima, Tomoaki Maruyama, Tomonori Iwasaki, D Murakami, M Tanaka, Haruaki Hayasaki and Youichi Yamasaki :
Association between mouth opening and upper body movement with intake of different-size food pieces during eating.,
Archives of Oral Biology, Vol.57, No.3, 307-313, 2012.

(要約): Head rotation is coordinated with mandibular movement during mouth opening, and the range of head rotation and mouth opening change with food size. However, past research did not include upper body movement, and no reports have related head and mandibular movement during realistic eating. The purpose of this study was to analyse head and mandibular movements with intake of different-sized food pieces during realistic eating. The test food consisted of apple cut into two different cube sizes (10mm and 20mm). Head and mandibular movements of 20 healthy young adults eating the apple pieces were simultaneously recorded in three dimensions by a wireless opto-electronic system. Reflective markers were attached to the upper lip and chin to measure the mouth opening range. Five markers were attached to eyeglasses frames to measure linear motion and rotation of the head. One marker was attached to the jugular notch of the sternum to measure linear motion of the upper body. Linear motion, and the inclination angle of the head and upper body, and mouth opening range were compared during intake of different-sized apple pieces. Mouth opening, head-neck rotation angle and the amount of upper body forward translation and inclination increased with larger apple pieces. However, isolated relative head motion was stabilized. We conclude that upper body forward motion and head-neck rotation assist mouth opening whilst stabilizing head orientation, and that the range of head-neck rotation angle, upper body translation and range of mouth opening change with food size during realistic eating.
(キーワード): Adult / Biomechanical Phenomena / Eating / 女性 (female) / Head Movements / Humans / 男性 (male) / Mandible / Mouth / Movement / Neck / Range of Motion, Articular / Sex Factors / Thorax
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.archoralbio.2011.08.023
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21975117; ● Summary page in Scopus @ Elsevier: 2-s2.0-84857626456

(DOI: 10.1016/j.archoralbio.2011.08.023, PubMed: 21975117, Elsevier: Scopus) Hiroko Hasegawa, Issei Saitoh, Kuniko Nakakura-Ohshima, Koki Shigeta, Toshihiro Yoshihara, Shigeaki Suenaga, Emi Inada, Tomonori Iwasaki, Yuko Matsumoto and Youichi Yamasaki :
Condylar shape in relation to anterior disk displacement in juvenile females,
Cranio, Vol.29, No.2, 100-110, 2011.

(要約): The purpose of the study was to test the hypothesis that condylar shape varies based upon the condition of anterior disk displacement in young adolescent patients with temporomandibular disorder (TMD). The study design consisted of 96 juvenile female patients (aged 9 to 20; 15.1 +/- 2.3 yrs.) with clinical signs and/or symptoms of TMD. Bilateral high-resolution magnetic resonance imaging scans were performed in frontal and horizontal views with the mandible in the closed position. Disk positions were evaluated to classify the patients into three diagnostic groups. The results of the study, using ANOVA and Bonferroni tests, demonstrated significant differences among the groups. The conclusion drawn from the study was that condylar shape and size vary based on anterior disk position in juvenile females with TMD. The study's results suggest that disk displacement results in a smaller condyle.
(キーワード): Adolescent / Cephalometry / 子ども (children) / 女性 (female) / Humans / Image Enhancement / Image Processing, Computer-Assisted / Joint Dislocations / 磁気共鳴映像法 (magnetic resonance imaging) / Mandibular Condyle / Range of Motion, Articular / Temporomandibular Joint Disc / Temporomandibular Joint Disorders / Young Adult
(出版サイトへのリンク): ● Publication site (DOI): 10.1179/crn.2011.018
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21661584; ● Summary page in Scopus @ Elsevier: 2-s2.0-79959619099

(DOI: 10.1179/crn.2011.018, PubMed: 21661584, Elsevier: Scopus) Tomonori Iwasaki, Issei Saitoh, Yoshihiko Takemoto, Emi Inada, Ryuzo Kanomi, Haruaki Hayasaki and Youichi Yamasaki :
Evaluation of upper airway obstruction in Class II children with fluid-mechanical simulation.,
American Journal of Orthodontics and Dentofacial Orthopedics (AJO-DO), Vol.139, No.2, e135-45, 2011.

(要約): The purpose of this study was to test the null hypothesis that dolichofacial and brachyfacial children with Class II malocclusion do not differ in upper airway obstruction. Furthermore, the ability of fluid-mechanical simulation to detect airway obstruction within the limitations of simulation was examined. Forty subjects from 7 to 11 years of age with Class II malocclusion participated and were divided into 2 groups, dolichofacial and brachyfacial, based on their Frankfort mandibular plane angles. Cone-beam computed tomography images supplied the shape of the entire airway. Two measures of respiratory function, air velocity and pressure, were simulated by using 3-dimensional images of the airway. The images and simulations were compared between the 2 facial types. The size of the upper airway did not differ statistically between facial types; however, the simulated maximal pressure and velocity of the dolichofacial type were significantly higher than those of the brachyfacial type. Airway obstruction differs with the Frankfort mandibular plane angle, even though the depth and cross-sectional area of the airway do not. The fluid-mechanical simulation system developed in this study detected differences in airway obstruction that were not apparent from morphologic studies.
(キーワード): Airway Obstruction / Airway Resistance / Anatomy, Cross-Sectional / Cephalometry / 子ども (children) / Computer Simulation / Cone-Beam Computed Tomography / 顔 (face) / Humans / Hydrodynamics / Imaging, Three-Dimensional / Malocclusion, Angle Class II / Maxillofacial Development / Mouth Breathing / Nasal Cavity / Observer Variation / Pharynx / 圧力 (pressure) / Pulmonary Ventilation / Statistics, Nonparametric / Vertical Dimension
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.ajodo.2010.08.014
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21300224; ● Summary page in Scopus @ Elsevier: 2-s2.0-79551709509

(DOI: 10.1016/j.ajodo.2010.08.014, PubMed: 21300224, Elsevier: Scopus) Kuniyasu Kuroda, Issei Saitoh, Emi Inada, Yoshihiko Takemoto, Tomonori Iwasaki, Yoko Iwase, Chiaki Yamada, Miyuki Shinkai, Yuko Matsumoto, Hiroko Hasegawa, Youichi Yamasaki and Haruaki Hayasaki :
Head motion may help mouth opening in children.,
Archives of Oral Biology, Vol.56, No.1, 102-107, 2011.

(要約): Concomitant head and mandibular movement during jaw function is well known in adults; however, its importance in children has not been studied. The brain attains 85-90% of its adult weight at 5 years of age, though the maximum rate of condylar growth is attained at approximately 14 years of age. These findings suggest that the coordination of the head and mandible may differ between children and adults. This study investigated head and mandibular movements of 19 children with complete primary dentition (average age: 5 years 5 months) and compared their functional integration of jaw and head movements to those of 16 female adults (average age: 20 years 3 months) with permanent dentition. Although the mandibular opening distance was significantly greater in the adults, the magnitude of concomitant head motion was greater in children. The results suggest that head extension in children helps increase the magnitude of mouth opening more than in adult women.
(キーワード): Age Factors / 脳 (brain) / 子ども (children) / Child, Preschool / Dental Occlusion / Dentition, Permanent / Electronics / 女性 (female) / Head Movements / Humans / Imaging, Three-Dimensional / 男性 (male) / Mandible / Mandibular Condyle / Masticatory Muscles / Photography / Range of Motion, Articular / Rotation / 顎関節 (temporomandibular joint) / Tooth, Deciduous / Young Adult
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.archoralbio.2010.08.014
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20869696; ● Summary page in Scopus @ Elsevier: 2-s2.0-78650179279

(DOI: 10.1016/j.archoralbio.2010.08.014, PubMed: 20869696, Elsevier: Scopus) Yoshihiko Takemoto, Issei Saitoh, Tomonori Iwasaki, Emi Inada, Chiaki Yamada, Yoko Iwase, Miyuki Shinkai, Ryuzo Kanomi, Haruaki Hayasaki and Youichi Yamasaki :
Pharyngeal airway in children with prognathism and normal occlusion.,
The Angle Orthodontist, Vol.81, No.1, 75-80, 2011.

(要約): To test the hypothesis that there is no difference in the pharyngeal airway width and the position of the maxillofacial skeleton between prognathic and normal children. Twenty-five girls with prognathism (mean, 7.9 ± 0.9 years old) and 15 girls with normal occlusion (mean, 8.4 ± 1.5 years) participated in this study. On each girl's lateral cephalogram, the coordinates of all points were marked and systematically digitized using a mechanical three-dimensional digitizing system. An independent-groups t-test was used to detect significant upper and lower pharyngeal width differences between the two groups. Correlations between the horizontal positions of each point and upper and lower pharyngeal widths were examined. Prognathic girls had a significantly wider lower pharyngeal airway compared with those with normal occlusion (P = .01). Furthermore, the horizontal coordinate of Ar was significantly positively correlated with lower pharyngeal airway width in both groups of girls. The hypothesis is rejected. The mandible in prognathic girls tends to be positioned more anteriorly, resulting in a wider lower pharyngeal airway.
(キーワード): Airway Obstruction / Case-Control Studies / Cephalometry / 子ども (children) / 女性 (female) / Humans / Hyperplasia / Mandible / Palatine Tonsil / Pharynx / Prognathism / Radiography / Statistics, Nonparametric
(出版サイトへのリンク): ● Publication site (DOI): 10.2319/013010-65.1
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20936957; ● Search Scopus @ Elsevier (PMID): 20936957; ● Search Scopus @ Elsevier (DOI): 10.2319/013010-65.1

(DOI: 10.2319/013010-65.1, PubMed: 20936957) Atsushi Fukami, Issei Saitoh, Emi Inada, Takeshi Oku, Yoko Iwase, Yoshihiko Takemoto, Chiaki Yamada, Tomonori Iwasaki, Hiroko Hasegawa, Naoko Kubota, Tomoya Murakami, Kanami Harada, Megumi Nishi, Sachiko Kinjo, Noriko Igata, Haruaki Hayasaki and Youichi Yamasaki :
A reproducibility method to test lip-closing strength in preschool children.,
Cranio, Vol.28, No.4, 232-237, 2010.

(要約): This cross-sectional study tested the reproducibility of a simple button-pulling system for measuring lip-closing strength in normal preschool children and compared their strength to that of normal adults. The sample consisted of 348 preschool children and 123 adults. Lip-closing strength was measured by inserting a button, fastened to a piece of string, into the vestibule between the incisors and lips with minimal mouth opening. The string was attached to a digital tension gauge and was pulled parallel to the floor. Maximum tension, with three repetitions, was recorded at the instant that the button was pulled out of the mouth. Multilevel statistical models were used to evaluate any differences in contractive muscle strength between age groups and between the genders. The strength in children increased significantly from three years to five years (p<0.01). Gender-related differences were found in adults but not in preschool children. Inter-individual variation at each age was larger than intra-individual variation. Measurement of lip-closing strength by button pulling is highly reproducible in children and has potential clinical and research applications.
(キーワード): Adult / Age Factors / Child, Preschool / Cross-Sectional Studies / Facial Muscles / 女性 (female) / Humans / 口唇 (lip) / 男性 (male) / Muscle Contraction / Muscle Strength / Muscle Tonus / Posture / Reproducibility of Results / Sex Factors / Stress, Mechanical / Supine Position / Young Adult
(出版サイトへのリンク): ● Publication site (DOI): 10.1179/crn.2010.032
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21032977; ● Summary page in Scopus @ Elsevier: 2-s2.0-79951788069

(DOI: 10.1179/crn.2010.032, PubMed: 21032977, Elsevier: Scopus) 山崎要一, 岩﨑智憲, 早崎治明, 齋藤一誠, 徳冨順子, 八若保孝, 井上美津子, 朝田芳信, 田村康夫, 嘉ノ海龍三, 牧憲司, 吉原俊博, 船津敬弘, 手島陽子, 上里千夏, 山下一恵, 井出正道, 栗山千裕, 近藤亜子, 嘉藤幹夫, 渡邉京子, 藤田優子, 長谷川大子, 稲田絵美, 朝田芳信 :
日本人小児の永久歯先天性欠如に関する疫学調査,
小児歯科学雑誌, Vol.48, No.1, 29-39, 2010年.

(要約): 永久歯の先天性欠如は，その発現部位や欠如歯数によって様々な歯列咬合異常を誘発するため，小児期からの健全な永久歯咬合の育成を目標とした継続的な口腔管理を行う上で大きな問題となる．我が国の先天性欠如の発現頻度の報告は，単一の医療機関を受診した小児患者の資料に基づいたものが多く，被験者数も限られている．そこで，日本小児歯科学会学術委員会の企画で国内の7 大学の小児歯科学講座が中心となり，我が国初の永久歯先天性欠如に関する全国規模の疫学調査を実施した．参加7 大学の代表者と実務者による全体打ち合わせ会を通して，調査方法の規格化や症例の審議を重ね，調査の信頼性向上に努めた．対象者は，大学附属病院の小児歯科，またはこれらの大学の調査協力施設に来院し，エックス線写真撮影時の年齢が7 歳以上であった小児15,544 名(男子7,502 名，女子8,042 名)とした．第三大臼歯を除く永久歯の先天性欠如者数は1,568 名，発現頻度は10.09%であり，男子が9.13%，女子が10.98%であった．上顎では4.37%，下顎では7.58%に認められた．上顎および下顎における左右の頻度の差は0.11%，0.14%であり左右差は小さかった．歯種別では，下顎第二小臼歯に最も多く認められ，次いで下顎側切歯，上顎第二小臼歯，上顎側切歯の順であった．
(キーワード): 日本人小児 / 永久歯 / 先天性欠如 / 疫学調査 / 全国調査
(出版サイトへのリンク): ● Publication site (DOI): 10.11411/jspd.48.1_29
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390001205519843456; ● Search Scopus @ Elsevier (DOI): 10.11411/jspd.48.1_29

(DOI: 10.11411/jspd.48.1_29, CiNii: 1390001205519843456) 西嶋奈緒美, 深水篤, 岩﨑智憲, 武元嘉彦, 窪田直子, 稲田絵美, 井形紀子, 奥猛志, 齋藤一誠, 早崎治明, 山崎要一 :
幼児期の顔面軟組織の三次元形態解析 : 2. 幅径と高径について,
小児歯科学雑誌, Vol.47, No.5, 726-731, 2009年.

(要約): 顔面の形態は歯科だけでなく，人体寸法・形状という観点からも関心が持たれている．しかし，小児を対象とした近年の報告は限られており，特に幼児に関する報告は見当たらない．そこで，本研究はレーザー型三次元非接触型デジタイザを用い，鹿児島市のT 保育園・幼稚園に通園する健康な4∼6 歳の幼児(年齢毎に男女各20 名:計120 名)の顔面形態を計測し，成長に伴う変化と性差について横断的検討を行なった．計測項目は幅径として，外眼角幅径，内眼角幅径，鼻翼外側間幅径，口裂幅径の4 個，高径として，鼻部高径，上顔面高径，口裂高径，顔面高径，下顔面高径，赤唇高径の6 個を設定した．全体として，増齢的に幅径・高径が増加する傾向を認めた．しかし，5 歳と6 歳の年齢間には多くの計測項目において有意な差を認めたものの，4 歳と5 歳の年齢間では女児の2 項目だけに有意差を認めたことから，この2 年間においても1 年毎に成長量が異なることが示唆された．幅径の計測項目は，頭蓋に近い，より上方の計測項目ほど成人に近い値を示した．年齢毎に行なった性差の検定では，3 つの年齢における，それぞれ10 個の計測項目，計30 項目の中で5 個の項目において有意差を認めたが，一定の傾向は見られなかった．以上より，幼児の顔面は全体として成長していく中で，その量は年齢，性別，部位のそれぞれにおいて特徴があることが示唆された．
(キーワード): 顔面形態 / 軟組織 / 三次元計測 / 幼児 / 幅径と高径
(出版サイトへのリンク): ● Publication site (DOI): 10.11411/jspd.47.5_726
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390282680496434048; ● Search Scopus @ Elsevier (DOI): 10.11411/jspd.47.5_726

(DOI: 10.11411/jspd.47.5_726, CiNii: 1390282680496434048) Tomonori Iwasaki, Haruaki Hayasaki, Yoshihiko Takemoto, Ryuzo Kanomi and Youichi Yamasaki :
Oropharyngeal airway in children with Class III malocclusion evaluated by cone-beam computed tomography.,
American Journal of Orthodontics and Dentofacial Orthopedics (AJO-DO), Vol.136, No.3, 318.e1-9;discussion3189, 2009.

(要約): Upper airway size is increasingly recognized as an important factor in malocclusion. However, children with Class III malocclusion are somewhat neglected compared with those with a Class II skeletal pattern. Therefore, the purpose of this study was to establish the characteristic shape of the oropharyngeal airway (OA) in children with Class III malocclusion. The sample comprised 45 children (average age, 8.6 +/- 1.0 years) divided into 2 groups: 25 with Class I and 20 with Class III malocclusions. OA size of each group was evaluated by cone-beam computed tomography. Cluster analysis, based on OA shape, redivided the subjects into wide, square, and long types. The distributions of Class I and Class III subjects were compared among the types. The Class III group showed statistically larger OA area and width compared with the Class I group. Area was positively correlated with Class III severity. The square type included 84% of the Class I malocclusions but only 30% of the Class III malocclusions, indicating that the OA in Class III malocclusion tends to be flat. The Class III malocclusion is associated with a large and flat OA compared with the Class I malocclusion.
(キーワード): Anatomy, Cross-Sectional / Cephalometry / 子ども (children) / Cone-Beam Computed Tomography / Epiglottis / 女性 (female) / Humans / Image Processing, Computer-Assisted / Imaging, Three-Dimensional / 男性 (male) / Malocclusion, Angle Class I / Malocclusion, Angle Class III / Mandible / Maxilla / Nasal Bone / Nasopharynx / Oropharynx / Palatine Tonsil
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.ajodo.2009.02.017
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19732662; ● Summary page in Scopus @ Elsevier: 2-s2.0-69249239128

(DOI: 10.1016/j.ajodo.2009.02.017, PubMed: 19732662, Elsevier: Scopus) 岩﨑智憲, 早崎治明, 嘉ノ海龍三, 齊藤一誠, 山崎要一 :
上気道流体シミュレーションからみた通気状態が顎顔面形態に及ぼす歯科的影響,
小児耳鼻咽喉科, Vol.30, No.1, 5-9, 2009年.

(キーワード): 上気道流体シミュレーション / CT / 通気障害部位 / 歯科的影響
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390001205465449984

(CiNii: 1390001205465449984) 石谷徳人, 重田浩樹, 長谷川大子, 岩﨑智憲, 森主宜延, 小椋正 :
当科外来における20年間の思春期顎関節症患者の実態調査,
小児歯科学雑誌, Vol.40, No.5, 797-802, 2002年.

(要約): 講座開設以来約20年間に,鹿児島大学歯学部附属病院小児歯科外来に来院した思春期の顎関節症患者の実態調査を行い,前半期10年,後半期10年で比較し,検討を行った． 来院患者の実態調査より,来院患者数は前半期に比べ,後半期で増加している．男女比については20年間を通じて女子が男子と比べて,高頻度を示し,後半期では前半期より女子の比率が増加している．主訴別患者数,初発症状,初診時臨床症状についてはいずれも頻度順には変化はないものの,前半期に比べて後半期で,疼痛の割合が増加し,雑音の割合が減少している． 治療の実態調査より,治療法では前半期に比べて後半期に咬合治療の割合が大きく減少し,理学療法,薬物療法はその割合が大きく増加しているものの,治療効果については前半期に比べ,後半期では大きな変化は見られなかった．
(キーワード): 思春期 / 顎関節症 (temporomandibular disorder) / 実態調査
(出版サイトへのリンク): ● Publication site (DOI): 10.11411/jspd1963.40.5_797
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390282679663517184; ● Search Scopus @ Elsevier (DOI): 10.11411/jspd1963.40.5_797

(DOI: 10.11411/jspd1963.40.5_797, CiNii: 1390282679663517184) 岩﨑智憲, 小椋正 :
叢生者の成長発達に伴う第一大臼歯の移動様相,
小児歯科学雑誌, Vol.39, No.5, 1025-1035, 2001年.

(要約): 成長発達期における叢生者の第一大臼歯の移動様相を明らかにするため,Hellmanの歯齢IIIAからIVAにかけて経年的に得られた叢生者の側貌頭部エックス線規格写真を用いて,叢生者の第一大臼歯の顎骨に対する前後的位置ならびに歯軸の成長発達に伴う変化を調査し,以下の結論を得た. 1.ANS-PNSとMe-Goについて,IIIA,IVAいずれの時期も男女ともに叢生群は正常群より小さかった. 2.上顎第一大臼歯のIIIAからIV Aまでの前方移動量は男女とも叢生群は正常群より有意に大きかった. 3.IIIAでの∠U6-Pal.Pl.は男女とも叢生群は正常群より小さく,上顎第一大臼歯は遠心に傾斜していた.その後,IIIAからIVAまでの∠U6-Pal.Pl.の変化量は男女とも叢生群は正常群より有意に大きく,上顎第一大臼歯は大きく近心に傾斜した. 4.IIIAからIVAまでの下顎の第一大臼歯の前方移動量は男女とも叢生群と正常群の間に有意差を認めなかった.叢生者の上顎第一大臼歯はIIIAでは正常者より遠心に傾斜して萌出するが,その後歯齢の増加に伴い大きく近心に傾斜し,IVAでは正常者より近心に移動することが示された.
(キーワード): 叢生 / 第一大臼歯 / 近心移動 / 側貌頭部エックス線規格写真
(出版サイトへのリンク): ● Publication site (DOI): 10.11411/jspd1963.39.5_1025
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390001204686927616; ● Search Scopus @ Elsevier (DOI): 10.11411/jspd1963.39.5_1025

(DOI: 10.11411/jspd1963.39.5_1025, CiNii: 1390001204686927616) 岩﨑智憲 :
Hellmanの歯齢IICからIVAにおける叢生と咀嚼筋筋電図との関係,
小児歯科学雑誌, Vol.39, No.5, 986-995, 2001年.

(出版サイトへのリンク): ● Publication site (DOI): 10.11411/jspd1963.39.5_986
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.11411/jspd1963.39.5_986

(DOI: 10.11411/jspd1963.39.5_986) 岩﨑智憲, 小椋正 :
Hellman歯齢IICからIVAまでの叢生者の顎骨歯槽基底部の成長様相,
小児歯科学雑誌, Vol.39, 712-717, 2001年.

(出版サイトへのリンク): ● Publication site (DOI): 10.11411/jspd1963.39.3_712
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.11411/jspd1963.39.3_712

(DOI: 10.11411/jspd1963.39.3_712) 岩﨑智憲, 森主宜延, 堀川清一, 旭爪伸二, 小椋正 :
Hellmanの歯齢に基づく叢生歯列者の顎顔面・歯列形態の経年的研究,
小児歯科学雑誌, Vol.34, No.4, 924-941, 1996年.

(要約): 永久歯列における叢生の発生過程について,歯列模型ならびに側貌頭部エックス線規格写真により検討されている．しかし,明確に解決されているとは言えない．本研究は,Hellmanの歯齢に従った経年的歯列模型ならびに,頭部エックス線規格写真の分析から,永久歯列における叢生の成り立ちについて検討した．対象は,経年的資料が得られた男子12名,女子14名の計26名であり,歯列叢生度(Arch Length Discrepancy)により正常歯列群15名と叢生歯列群11名の2群に分け比較し検討した．得られた結果は,以下の通りである．1)叢生歯列群の上下顎骨体はHellmanの歯齢IIIA以後,正常歯列群と比較し,近遠心的に短い傾向にあった．2)叢生歯列群の前歯歯軸傾斜は,Hellmanの歯齢IIIA以後,正常歯列群と比較し,小さい傾向にあった．3)叢生歯列群の歯列形態において,歯列幅径がHellmanの歯齢IICにおいて歯列叢生度と有意に正の相関関係を示し,IIIA以後は,歯列弓長径と歯列弓周長ともに,歯列叢生度と有意に正の相関関係を示した．逆に,歯冠幅径については,歯列叢生度と有意に負の相関関係を示した．以上の所見から,永久歯列における叢生は,少なくともHellmanの歯齢IIIAからすでに,歯列形態にとどまらず顎顔面形態においても,歯列の叢生度と関連する変化が生じていることが示唆された．
(キーワード): 叢生 / 顎顔面形態 / 歯列形態 / 経年的研究
(出版サイトへのリンク): ● Publication site (DOI): 10.11411/jspd1963.34.4_924
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390282679659630080; ● Search Scopus @ Elsevier (DOI): 10.11411/jspd1963.34.4_924

(DOI: 10.11411/jspd1963.34.4_924, CiNii: 1390282679659630080) 岩﨑智憲 :
正常歯列者と叢生者の咀嚼機能の差についての経年的研究,
小児歯科学雑誌, Vol.32, No.1, 135-161, 1994年.

(要約): 叢生者の咀嚼機能の発育様相を明らかにする目的で,経年的に得られた咀嚼筋筋電図を用いて正常歯列者群と叢生歯列者群の比較を行った. 叢生歯列者群の筋電図積分値は,側頭筋優位から咬筋優位になるのが正常歯列老群より遅れた. 叢生歯列者群の咀嚼リズムの長さは歯牙年齢の進行に伴い短縮傾向を示したが,正常歯列者群より長かった.また,叢生歯列者群は歯牙年齢の進行に伴い咀嚼リズムは安定してきたが,正常歯列者群より不安定だった. 叢生歯列者群のsilent period出現頻度は,IVAで90%に達せず,正常歯列者群より低かった.また,叢生歯列者群のsilent period durationは歯牙年齢の進行に伴い短縮したが,正常歯列者群よりIIA-IIIB間で長かった. 以上のことから,叢生歯列者の咀嚼機能の発育様相は正常歯列者と同様の様相を示すものの,正常歯列者より遅延する事が示唆された.
(キーワード): 叢生 / 咀嚼機能 / 経年的研究
(出版サイトへのリンク): ● Publication site (DOI): 10.11411/jspd1963.32.1_135
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390001204685353728; ● Search Scopus @ Elsevier (DOI): 10.11411/jspd1963.32.1_135

(DOI: 10.11411/jspd1963.32.1_135, CiNii: 1390001204685353728)

MISC

Tomonori Iwasaki, Hideo Sato, Hokuto Suga, Yoshihiko Takemoto, Emi Inada, Issei Saitoh, Eriko Kakuno, Ryuzo Kanomi and Youichi Yamasaki :
Authors' response,
American Journal of Orthodontics and Dentofacial Orthopedics (AJO-DO), Vol.152, No.4, 442-443, 2017.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.ajodo.2017.07.001
(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-85032219266

(DOI: 10.1016/j.ajodo.2017.07.001, Elsevier: Scopus)

総説・解説

保坂啓一, 渡邉佳一郎, 田中栄二, 中島正俊, 岩﨑智憲 :
【小児のCR(コンポジットレジン)充填アップデート】接着システムのアップデート,
小児歯科臨床, Vol.28, No.12, 15-26, 2023年12月. 山崎要一, 岩﨑智憲 :
子どもの歯科からみた呼吸障害の問題点,
小児保健かごしま, Vol.33, 37-42, 2020年8月.

(キーワード): 睡眠時無呼吸症候群(合併症) 局所解剖学口 *口腔疾患(診断,合併症) 呼吸器系 *呼吸障害(合併症) 顔貌コンピュータシミュレーション *小児歯科医療人体模型三次元イメージング評価基準流体力学病態生理 *口腔機能発達不全症(診断,合併症) ヒト小児(6∼12) 歯学
(徳島大学機関リポジトリ): ● Metadata: 117485
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1050856583396321792

(徳島大学機関リポジトリ: 117485, CiNii: 1050856583396321792) 岩﨑智憲 :
小児期の上気道通気障害がもたらす顎顔面歯列咬合形態への影響と小児歯科からの睡眠医療への貢献,
小児歯科学雑誌, Vol.54, No.1, 1-8, 2016年.

(要約): 小児期の呼吸が顎顔面形態におよぼす影響について数多くの研究が行われてきた．しかし，上気道通気状態の適切な評価が困難なためコンセンサスは得られていない．そこで我々はコーンビームエックス線CT データを用いて上気道3 次元モデルを構築し，空気の流れを機能的に評価する流体解析を用いた精度の高い上気道通気状態の解析方法を確立した．その結果，ClassⅢ小児の咽頭気道形態では咽頭部の長径，幅径が大きく，低位舌を認めることを示す一方，ClassⅡ小児では上気道通気障害が長顔傾向の原因になり得ること，また，上気道の中でも鼻腔，上咽頭，口腔咽頭，下咽頭など様々な部分がその原因部位になることを明らかにした．さらに上顎骨急速拡大により鼻腔通気状態が改善すること，咽頭気道の気道体積が増大すること，鼻腔通気状態の改善に伴い低位舌が改善することを明らかにし，上顎骨急速拡大が上気道通気障害の改善におよぼすメカニズムを明らかにした．今後，有病率が2%と高頻度で，医科的対応法による治療成績が70%程度とされる小児閉塞性睡眠時無呼吸症候群に対して，その有効性が指摘されている上顎骨急速拡大や下顎前方誘導などの歯科的対応法を応用した治療効果のエビデンスを発信し，小児歯科からの新たな社会貢献に努めたい．
(キーワード): Class II / Class III / 上気道流体シミュレーション / 上顎骨急速拡大 / 睡眠時無呼吸症候群
(徳島大学機関リポジトリ): ● Metadata: 115795
(出版サイトへのリンク): ● Publication site (DOI): 10.11411/jspd.54.1_1
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390282680495505152; ● Search Scopus @ Elsevier (DOI): 10.11411/jspd.54.1_1

(徳島大学機関リポジトリ: 115795, DOI: 10.11411/jspd.54.1_1, CiNii: 1390282680495505152) Tomonori Iwasaki and Youichi Yamasaki :
Relation between maxillofacial form and respiratory disorders in children,
Sleep and Biological Rhythms, Vol.12, No.1, 2-12, Jan. 2014.

(出版サイトへのリンク): ● Publication site (DOI): 10.1111/sbr.12041
(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-84892899068

(DOI: 10.1111/sbr.12041, Elsevier: Scopus) 岩﨑智憲 :
上気道流体シミュレーションを用いた通気状態評価の臨床応用,
鹿児島大学歯学部紀要, Vol.31, 59-70, 2001年.

講演・発表

Yutaro Maeda, Naoki Shimojima, Kimiko Ueda Yamaguchi, Shinichi Nishibe, Shiroh Isono, Tomonori Iwasaki and Tatsuo Kuroda :
Digitizing and Visualization of airflow alterations by computational fluid dynamics after slide tracheoplasty for congenital tracheal stenosis,
The 56th Annual Meeting of the Pacific Association of Pediatric Surgeons, Bali Indonesia, Sep. 2023. Kimiko Ueda Yamaguchi, Naoki Shimojima, Yutaro Maeda, Junya Sugihara, Atsushi Harada, Yoshihito Yamakawa, Shinichi Nishibe, Shiroh Isono, Tatsuo Kuroda and Tomonori Iwasaki :
Preoperative evaluation of congenital tracheal stenosis using computational fluid dynamics,
The 56th Annual Meeting of the Pacific Association of Pediatric Surgeons, Bali Indonesia, Sep. 2023. kei Maeo, Takamasa Kitamura, Hitomi Ishii, Ryuzo Kanomi and Tomonori Iwasaki :
Association between low tongue posture, maxillary dentition form, and nasal airway ventilation condition -CFD study-,
Korean Academy of Pediatric Dentistry 2023 Conference, Apr. 2023. yukari Suzuki, Takamasa Kitamura, Hitomi Ishii, Ryuzo Kanomi and Tomonori Iwasaki :
CBCT study of the muscle composition of lips and the tongue of children with bimaxillary protrusion,
Korean Academy of Pediatric Dentistry 2023 Conference, Apr. 2023. Wakana Kohira, Takamasa Kitamura, kei Maeo, Hitomi Ishii, Ryuzo Kanomi and Tomonori Iwasaki :
Does Rapid Maxillary Expansion with Lip Traning and Myofunctional Therapy improve nasal airway ventilation obstruction?,
Korean Academy of Pediatric Dentistry 2023 Conference, Apr. 2023. Takamasa Kitamura, Kei Maeo, Yukari Suzuki, Wakana Kohira and Tomonori Iwasaki :
Adverse effects of oral development caused by jawbone destruction lesions in early childhood,
Korean Academy of Pediatric Dentistry 2023 Conference, Apr. 2023. Yuki Akazawa, Kimiko Ueda Yamaguchi, Hiroshi Nakagawa and Tomonori Iwasaki :
A case of using a mouthpiece for bites in perioperative,
Oral Care, Apr. 2022. Tomonori Iwasaki :
Indicarion of the dental treatment for pediatric OSAS using computer fluid dynamics,
The 21st Genaral Assembly, 41th annual Scientific Meeting and Dental Exhibition, Kaohsiung Taiwan, Oct. 2018. Tomonori Iwasaki, Hideo Sato, Hokuto Suga, Yoshihiko Takemoto, Emi Inada, Issei Saitoh, Eriko Kakuno, Ryuzo Kanomi and Youichi Yamasaki :
Relationships between nasal resistance, adenoids, tonsils, and tongue posture and maxillofacial dentition in Class II and Class III children,
10th Biennial Conference of the Pediatric Dentistry Association of Asia (PDAA), Tokyo, May 2016. Tomonori Iwasaki :
Obstructive Sleep Apnea Syndrome,
Stanford Sleep and Circadian Neurobiology Laboratory, Sleep seminar, Palo Alto, CA, USA, Nov. 2014. Tomonori Iwasaki :
Can we prevent childhood obstructive sleep apnea syndrome? -Clinical application using computational fluid dynamics -,
The 1st Annual Conference in Pediatric Dentistry between Gangneung-Wonju National University and Kagoshima University, Kagoshima, Jun. 2014. Tomonori Iwasaki :
Can We Prevent OSA? - Tongue posture improvement and pharyngeal airway enlargement as secondary effects of rapid maxillary expansion,
The 5th World Congress on Sleep Medicine, Valencia, Sep. 2013. Tomonori Iwasaki, Ryuzo Kanomi, Eriko Kakuno, Issei Saitoh, Haruaki Hayasaki and Youichi Yamasaki :
Evaluations of upper airway ventilation conditions in children with different anteroposterior skeletal patterns using fluid-mechanical simulation,
The 24th Congress of International Association of Paediatric Dentistry (IAPD), Seoul, Jun. 2013. Tomonori Iwasaki, Issei Saitoh, Mizue Harada, Keiichi Miyashita, Syouji Matsune, Yoshihiko Takemoto, Atsushi Fukami, Hideo Sato, Emi Inada, Hiroko Hasegawa, Eriko Kakuno, Ryuzo Kanomi, Haruaki Hayasaki, Yuuichi Kurono and Youichi Yamasaki :
Detection of specific obstruction sites using fluid-structure interaction analysis in children with upper airway obstruction,
7th Asian Sleep Research Society Congress 2012, Taipei, Nov. 2012. Tomonori Iwasaki :
Can We Prevent OSAS? Clinical Application to OSAS of Children Using Computational Fluid Dynamics,
The 7th Asian Sleep Research Society Congress, Taipei, Nov. 2012. Tomonori Iwasaki, Issei Saitoh, Ryuzo Kanomi, Haruaki Hayasaki and Youichi Yamasaki :
Improving tongue posture and pharynx airway as a side effect of rapid maxillary expansion in children: A cone-beam computed tomography study,
112th Annual Session 2012 - American Association of Orthodontists, Honolulu, May 2012. Tomonori Iwasaki, Issei Saitoh, Mizue Harada, Keiichi Miyashita, Shoji Matsune, Yoshihiko Takemoto, Emi Inada, Ryuzo Kanomi, Haruaki Hayasaki, Yuichi Kurono and Youichi Yamasaki :
Detection of specific obstruction sites using fluid-structure interaction analysis in children with upper airway obstruction,
World Sleep 2011, Kyoto, Oct. 2011. Tomonori Iwasaki, Ryuzo Kanomi, Haruaki Hayasaki and Youichi Yamasaki :
Evaluation of upper airway obstruction in Class II children using fluid-mechanical simulation,
110th Annual Session 2010 - American Association of Orthodontists, Washington, D.C., Apr. 2010. 岩﨑智憲 :
OSA,
48, 2024年7月. Tomonori Iwasaki :
Pharyngeal airway research using computational fluid dynamics,
第48回日本睡眠学会, Jul. 2024. 上田(山口) 公子, 下島直樹, 前田悠太郎, 杉原潤哉, 原田篤, 山川允仁, 西部伸一, 磯野史朗, 黒田達夫, 岩﨑智憲 :
流体解析を用いた先天性気管狭窄症の術前評価,
第268回徳島医学会学術集会，2024年3月10日徳島大学大塚講堂徳島市, 2024年3月. 赤澤友基, 長谷川智一, 岩﨑智憲 :
多数の永久歯に著しい短根を認めた1例,
小児歯科学雑誌, Vol.62, 74, 2024年. 北村尚正, 與倉杏奈, 奥陽一郎, 前尾慶, 幸平若奈, 鈴木結加里, 山川允仁, 上田(山口) 公子, 石丸紘子, 佐藤秀夫, 嘉ノ海龍三, 山﨑要一, 岩﨑智憲 :
アデノイド肥大による鼻咽腔通気状態の流体力学的研究,
第42回日本小児歯科学会中四国地方会大会及び総会，2023年11月19日，米子市，鳥取県, 2023年11月. 中川弘, 上田(山口) 公子, 北村尚正, 赤澤友基, 山川允仁, 前尾慶, 幸平若奈, 鈴木結加里, 兼松めぐみ, 石川英子, 岡本悦子, 森重代, 横井久美子, 森本みどり, 岩﨑智憲 :
Down症候群患者における歯周炎評価指標 (PISA)と歯周病原菌叢の関連,
第40回日本障害者歯科学会総会および学術大会, 2023年11月. 前尾慶, 北村尚正, 石井瞳, 嘉ノ海龍三, 岩﨑智憲 :
低位舌の筋脂肪組成から見た舌の機能評価 CBCTのグレースケール値を用いた研究,
日本睡眠歯科学会, 2023年10月. 北村尚正, 前尾慶, 幸平若奈, 鈴木結加里, 山川允仁, 上田(山口) 公子, 嶋村洋介, 池田このみ, 齋藤吉紀, 柳原健一, 清水清恵, 竜立雄, 千葉伸太郎, 岩﨑智憲 :
肥満OSA患者のHounsfield Unitを用いた舌の筋・脂肪組織の定量的解析,
日本睡眠学会第45回定期学術集会，2023年9月15-17日，横浜, 2023年9月. 和田涼平, 渡邉佳一郎, 吉永薫, 金秀河, 花輪茂己, 田中茉里子, 坂本幸, 島田亜紀, 近藤英司, 北村尚正, 山崎裕行, 峯田一秀, 日浅雅博, 堀内信也, 岩﨑智憲, 橋本一郎, 田中栄二 :
徳島大学病院における過去10年間の口唇裂・口蓋裂患者に関する臨床統計調査,
日本口蓋裂学会雑誌, Vol.48, No.2, 200, 2023年5月.

(キーワード): 口蓋裂 / 統計 (statistics) / 大学病院 / ヒト; 男; 女; 歯学

近藤英司, 坂本幸, 島田亜紀, 吉永薫, 北村尚正, 山崎裕行, 峯田一秀, 渡邉佳一郎, 日浅雅博, 堀内信也, 岩﨑智憲, 橋本一郎, 田中栄二 :
徳島大学病院における口蓋裂児の滲出性中耳炎と鼓膜チューブ留置術の検討,
第47回日本口蓋裂学会, 2023年5月. 前尾慶, 北村尚正, 石井瞳, 嘉ノ海龍三, 岩﨑智憲 :
低位舌の筋脂肪組成から見た舌の機能評価 CBCTのグレースケールを用いた研究,
小児歯科学雑誌, 2023年5月. 幸平若奈, 北村尚正, 前尾慶, 石井瞳, 嘉ノ海龍三, 岩﨑智憲 :
上顎洞粘膜肥厚は上顎急速拡大とLip Training・MFTの併用で改善するか?,
小児歯科学雑誌, 2023年5月. 鈴木結加里, 北村尚正, 石井瞳, 嘉ノ海龍三, 岩﨑智憲 :
上下顎前突児の口唇ならびに舌のCBCTを用いた筋の組成に関する研究,
小児歯科学雑誌, 2023年5月. 上田(山口) 公子, 赤澤友基, 中川弘, 山川允仁, 鈴木結加里, 岩﨑智憲 :
長期管理中の9pトリソミー症候群の1例,
小児歯科学雑誌, Vol.61, 213, 2023年4月. 坂本幸, 近藤英司, 島田亜紀, 吉永薫, 北村尚正, 山崎裕行, 峯田一秀, 渡邉佳一郎, 日浅雅博, 堀内信也, 岩﨑智憲, 橋本一郎, 田中栄二 :
徳島大学病院における口蓋裂児の新生児聴覚スクリーニング結果と滲出性中耳炎罹患率,
日本口蓋裂学会雑誌, Vol.48, No.2, 153, 2023年4月.

(キーワード): *口蓋裂(合併症) *新生児スクリーニング *中耳炎-滲出性(診断,合併症) 発生率大学病院 *聴覚検査ヒト乳児(1∼23ヶ月) 幼児(2∼5) 男女歯学

近藤英司, 坂本幸, 島田亜紀, 吉永薫, 北村尚正, 山崎裕行, 峯田一秀, 渡邉佳一郎, 日浅雅博, 堀内信也, 岩﨑智憲, 橋本一郎, 田中栄二 :
徳島大学病院における口蓋裂児の滲出性中耳炎と鼓膜チューブ留置術の検討,
日本口蓋裂学会雑誌, Vol.48, No.2, 154, 2023年4月.

(キーワード): *口蓋裂(合併症) *中耳炎-滲出性(外科的療法,合併症) *中耳換気大学病院結果再現性ヒト乳児(1∼23ヶ月) 幼児(2∼5) 小児(6∼12) 青年期(13∼18) 男女歯学

上田(山口) 公子, 赤澤友基, 河原林啓太, 宮嵜彩, 北村尚正, 長谷川智一, 中川弘, 岩﨑智憲 :
当院小児摂食嚥下外来における初診時調査,
小児歯科学雑誌, Vol.61, 53-54, 2023年2月. 金秀河, 渡邉佳一郎, 吉永薫, 天眞寛文, 中上絵美子, 比嘉佳基, 坂本幸, 近藤英司, 島田亜紀, 峯田一秀, 石田創士, 宮嵜彩, 北村尚正, 日浅雅博, 堀内信也, 岩﨑智憲, 橋本一郎, 田中栄二 :
徳島大学病院における口唇口蓋裂センター設立前後での患者動向の変化金秀河(徳島大学大学院口腔科学教育部口腔顎顔面矯正学分野), 渡邉佳一郎, 吉永薫, 天眞寛文, 中上絵美子, 比嘉佳基, 坂本幸, 近藤英司, 島田亜紀, 峯田一秀, 石田創士, 宮嵜彩, 北村尚正, 日浅雅博, 堀内信也, 岩崎智憲, 橋本一郎, 田中栄二日本口蓋裂学会雑誌(0386-5185)47巻2号 Page135(2022.04),
日本口蓋裂学会雑誌, Vol.47, No.2, 135, 2022年5月. 黒厚子璃佳, 長谷川智一, 岩﨑智憲, 岩本勉 :
両側性に生じた下顎第一大臼歯生歯困難の1例,
日本小児歯科学会, Vol.60, 207, 2022年5月. 渡邉佳一郎, 天眞寛文, 吉永薫, 中上絵美子, 坂本幸, 近藤英司, 島田亜紀, 峯田一秀, 石田創士, 日浅雅博, 堀内信也, 岩﨑智憲, 橋本一郎, 田中栄二 :
Pre-epiglottic baton plateによる保存的治療で重度気道閉塞の改善がみられたPierre Robin Sequenceの1例,
日本口蓋裂学会雑誌, Vol.47, No.2, 116, 2022年4月.

(キーワード): *Pierre Robin症候群(合併症) *気道閉塞(合併症,診断,予後) 呼吸障害(病因,予後) *保存的療法哺乳障害(病因,予後) ヒト新生児男歯学

前尾慶, 北村尚正, 幸平若奈, 石井瞳, 嘉ノ海龍三, 岩﨑智憲 :
低位舌と上顎歯列形態ならびに鼻腔通気状態との関連流体力学的研究,
小児歯科学雑誌, Vol.60, No.2, 103, 2022年3月. 杉本明日菜, 北村尚正, 前尾慶, 岩﨑智憲, 岩本勉 :
心停止の既往がある先天性QT延長症候群の児に対し口腔内管理を行った1例,
小児歯科学雑誌, Vol.60, No.2, 205, 2022年3月. 奥陽一郎, 岩﨑智憲, 佐藤秀夫, 嘉ノ海龍三, 山崎要一 :
骨格性II級小児の口蓋扁桃肥大が気道閉塞・舌姿勢・歯軸傾斜に及ぼす影響,
小児歯科学雑誌, Vol.60, No.2, 132, 2022年3月. 北村尚正, 幸平若奈, 前尾慶, 岩本勉, 岩﨑智憲 :
幼児期の骨破壊性病変が及ぼす顎口腔発育への影響,
小児歯科学雑誌, Vol.60, No.2, 202, 2022年3月. 赤澤友基, 上田(山口) 公子, 中川弘, 岩﨑智憲 :
習癖による咬傷に対してマウスピースを使用した1例,
小児歯科学雑誌, Vol.60, 63-64, 2022年2月. 尼寺理恵, 上田(山口) 公子, 赤澤友基, 北村尚正, 岩﨑智憲 :
Streptococcus mutans定着時期に低濃度フッ素化合物を応用した小児の5歳時の齲蝕罹患状況,
小児歯科学雑誌, Vol.60, No.2, 55-56, 2022年2月.

(キーワード): *Streptococcus mutans *う蝕(予防,予後) *フッ素(治療的利用) ヒト乳児(1∼23ヶ月) 幼児(2∼5) 歯学

岩﨑智憲, 前尾慶, 幸平若菜, 北村尚正, 河原林啓太, 宮嵜彩, 赤澤友基, 上田(山口) 公子, 中川弘, 長谷川智一 :
小児閉塞性睡眠時無呼吸への対応と展望,
徳島県小児保健協会総会並びに第62回講演会, 3, 2021年9月. 岩﨑智憲 :
歯科タイトレーション法-OA治療における最適下顎位の再考- 上気道流体シミュレーションを用いた歯科タイトレーション,
日本睡眠学会定期学術集会プログラム・抄録集, Vol.46, 111, 2021年9月.

(キーワード): *咽頭(X線診断) X線CT *下顎前方移動術 *オクルーザルスプリントコンピュータシミュレーション三次元イメージング *睡眠時無呼吸-閉塞性(治療,X線診断) *流体力学ヒト歯学

岩﨑智憲 :
OSA鼻咽腔気流動態上顎急速拡大による鼻腔通気障害改善の適応症例を考える,
日本睡眠学会定期学術集会プログラム・抄録集, Vol.46, 157, 2021年9月.

(キーワード): 上顎骨鼻腔 *睡眠時無呼吸-閉塞性(診断) ヒト

岩﨑智憲, 杉山剛, 柳澤彩佳, 迫田莉奈, 久貝宗次郎, 奥陽一郎, 伴祐輔, 佐藤秀夫, 山崎要一 :
小児OSAに対するアデノイド切除・口蓋扁桃摘出術の新たな適応法の提案上気道流体シミュレーションを用いて,
日本睡眠学会定期学術集会プログラム・抄録集, Vol.46, 208, 2021年9月.

(キーワード): アデノイド切除扁桃摘出術 *睡眠時無呼吸-閉塞性(X線診断,外科的療法) ヒト小児(6∼12)

久貝宗次郎, 岩﨑智憲, 迫田莉奈, 奥陽一郎, 柳澤彩佳, 伴祐輔 :
上下顎前方移動術前後の気道通気状態に関する流体力学を用いた評価方法の検討,
日本睡眠学会定期学術集会プログラム・抄録集, Vol.43, No.2, 219, 2021年9月.

(キーワード): 呼吸器系 *下顎前方移動術 *睡眠時無呼吸-閉塞性(診断,外科的療法) 流体力学ヒト男女

迫田莉奈, 岩﨑智憲, 久貝宗次郎, 與倉杏奈, 奥陽一郎, 合田義仁, 嘉ノ海龍三, 山崎要一 :
上顎急速拡大は鼻腔通気障害を改善するか? 流体力学的研究,
小児歯科学雑誌, Vol.59, No.2, 79, 2021年5月.

(キーワード): 圧力咽頭扁桃咽頭 *口蓋拡大法鼻粘膜三次元イメージング *鼻腔通気度検査コーンビームCT *流体力学ヒト歯学

岩﨑智憲 :
口腔内装置の実際，小児に対する治療法の実際，顎発育との関連,
日本口腔外科学会雑誌, 2020年10月. 柳澤彩佳, 岩﨑智憲, 杉山剛, 菅北斗, 白澤良執, 山本祐士, 辻井利弥, 橋口真紀子, 佐藤秀夫, 山崎要一 :
上気道流体シミュレーションを用いた小児OSAの原因部位の特定と閉塞部位との識別,
第18回日本睡眠歯科学会, 2019年11月. 岩﨑智憲, 柳澤彩佳, 菅北斗, 白澤良執, 奥陽一郎, 佐藤秀夫, 山﨑要一 :
CT値を用いた上気道周囲筋の評価と上気道流体シミュレーヨンを併用したOSAS治療戦略の展開,
第35回「歯科医学を中心とした総合的な研究を推進する集い」, 2019年8月. 岩﨑智憲, 菅北斗, 柳澤彩佳, 白澤良執, 辻井利弥, 橋口真紀子, 武元嘉彦, 嘉ノ海龍三, 山崎要一 :
上気道流体シミュレーションを用いた口唇口蓋裂児の鼻腔の上顎急速拡大効果,
第57回日本小児歯科学会, 2019年6月. 岩﨑智憲 :
CFDによるOSA原因部位の特定と閉塞部位との鑑別診断睡眠学会,
第44回日本睡眠学会, 2019年6月. 岩﨑智憲 :
上気道流体シミュレーションを用いた小児OSAの原因部位特定について,
第17回日本睡眠歯科学会, 2018年11月. 山本祐士, 佐藤秀夫, 岩﨑智憲, 南彩佳, 菅北斗, 橋口真紀子, 稲田絵美, 奥猛志, 山崎要一 :
上顎急速拡大によりDown症候群児OSASの改善を認めた1症例流体シミュレーションを用いた閉塞原因部位の特定,
第33回日本障害者歯科学会, 2016年9月. 岩﨑智憲 :
睡眠時無呼吸症候群の原因部位特定システム,
第1回医工連携マッチング例会次世代医療システム産業化フォーラム2016, 2016年5月. 岩﨑智憲 :
小児期の上気道通気障害がもたらす顎顔面歯列咬合形態への影響と小児歯科からの睡眠医療への貢献,
第53回日本小児歯科学会大会, 2015年5月. 岩﨑智憲 :
上顎急速拡大による上気道通気状態の変化,,
第12回日本睡眠歯科学会, 2013年9月. 岩﨑智憲 :
小児OSAに対する上顎急速拡大の有効性の検討,
第38回日本睡眠学会, 2013年6月. 岩﨑智憲 :
上気道流体シミュレーションを用いた小児閉塞性睡眠時無呼吸症候群への取り組み,
第22回日本歯科医学会総会, 2012年11月. 岩﨑智憲, 齊藤一誠, 原田みずえ, 宮下圭一, 松根彰志, 武元嘉彦, 深水篤, 佐藤秀夫, 稲田絵美, 長谷川大子, 覚野恵梨子, 嘉ノ海龍三, 早崎治明, 黒野祐一, 山崎要一 :
上気道流体シミュレーションを用いた上顎骨急速拡大による歯科治療前後の吸気時咽頭気道圧の評価,
第37回日本睡眠学会, 2012年6月. 岩﨑智憲 :
閉塞性睡眠時無呼吸症候群への上気道流体シミュレーションの歯科的臨床応用,
第37回日本睡眠学会, 2012年6月. 岩﨑智憲, 齊藤一誠, 早﨑治明, 山崎要一 :
上気道流体シミュレーションを用いた小児閉塞性睡眠時無呼吸症候群への取り組み,
第27回「歯科医学を中心とした総合的な研究を推進する集い」, 2011年1月. 岩﨑智憲 :
口腔内装置の実際，小児に対する治療法の実際，顎発育との関連,
日本口腔外科学会雑誌, 2010年11月.

(キーワード): 睡眠時無呼吸症候群

岩﨑智憲, 齊藤一誠, 武元嘉彦, 嘉ノ海龍三, 早崎治明, 山崎要一 :
上顎急速拡大前後の鼻腔通気状態に関する流体シミュレーション評価,
第69回日本矯正歯科学会大会, 2010年9月. 岩﨑智憲, 嘉ノ海龍三, 早崎治明, 山崎要一 :
流体シミュレーションからみた上気道通気障害が上顎前突に及ぼす影響 BrachyとDolicho typeの比較,
第67回日本矯正歯科学会大会, 2008年9月. 岩﨑智憲, 嘉ノ海龍三, 山崎要一 :
コーンビームエックス線CTを用いた反対咬合児の下咽頭部気道断面形態に関する研究,
第46回日本小児歯科学会, 2008年6月. 岩﨑智憲, 嘉ノ海龍三, 山崎要一 :
上気道流体シミュレーションからみた呼吸が顎顔面形態に及ぼす歯科的影響,
第3回日本小児耳鼻咽喉科学会, 2008年6月.

研究会・報告書

岩﨑智憲 :
小児の閉塞性睡眠時無呼吸症候群の歯科的治療の適応について,
第23回成育歯科医療研究会大会, 2018年9月. 岩﨑智憲 :
流体解析を用いた小児 OSAS の原因部位特定,
第10回霧島睡眠カンファレンス, 2018年9月. 岩﨑智憲 :
小児の閉塞性睡眠時無呼吸症候群の歯科的治療の適応について,
第23回成育歯科医療研究会, 2018年9月. 岩﨑智憲 :
歯科からの小児睡眠医療への貢献 -気道に関するこれまでの研究を通して-,
第18回高知睡眠医学研究会, 2016年11月. 岩﨑智憲 :
成育歯科からの小児睡眠医療への貢献 -気道に関するこれまでの研究を通して-,
第21回成育歯科医療研究会, 2016年9月. 岩﨑智憲 :
睡眠時無呼吸症候群の原因部位特定システムの開発,
イノベーション・ジャパン2016 ∼大学見本市&ビジネスマッチング∼, 2016年8月. 岩﨑智憲 :
顎顔面部の流体構造連成解析を用いた気道通気状態解析システム -睡眠時無呼吸症候群の独創的診断ツールの開発と治療への展開-,
医療・福祉・創薬新技術説明会, 2016年7月. Maiko Hasegawa-Moriyama, Tomonori Iwasaki, Keika Mukaihara, Mina Masuda and Yuichi Kanmura :
Unsuccessful tracheal intubation in a patient with Kniest dysplasia undergoing repeated general anesthesia: a case report.,
JA Clinical Reports, Vol.4, No.1, 41, May 2018.

(要約): Kniest dysplasia is a type of chondrodysplasia characterized by severe craniofacial abnormalities including tracheomalacia, midface hypoplasia, and cleft palate. We previously described a 6-year-old girl with Kniest dysplasia, in whom glottic edema rapidly developed after tracheal intubation. At the age of 13 years, a reoperation was scheduled to correct talipes equinovarus but was subsequently canceled due to failure of tracheal intubation and subsequent glottic edema. Airway evaluation by endoscopy and computed tomography 1 month later revealed severe laryngeal narrowing. Therefore, the second anesthesia was maintained with spinal anesthesia combined with sciatic nerve block without tracheal intubation. Careful perioperative airway evaluation is required in patients with Kniest dysplasia, and alternative strategies for airway management other than tracheal intubation should be considered.
(出版サイトへのリンク): ● Publication site (DOI): 10.1186/s40981-018-0178-x
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32025981; ● Search Scopus @ Elsevier (PMID): 32025981; ● Search Scopus @ Elsevier (DOI): 10.1186/s40981-018-0178-x

(DOI: 10.1186/s40981-018-0178-x, PubMed: 32025981) 稲田絵美, 齊藤一誠, 村上大輔, 武元嘉彦, 森園健, 岩﨑智憲, 早崎治明, 山崎要一 :
幼児期に多数歯齲蝕を有した患児に対し包括的な長期管理を行った一例,
小児歯科学雑誌, Vol.51, No.4, 447-455, 2013年4月.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1573105975994001664

(CiNii: 1573105975994001664) 重田浩樹, 岩﨑智憲, 齊藤一誠, 早崎治明, 山崎要一 :
逆生埋伏した上顎右側中切歯の鼻側に埋伏過剰歯を有する症例の歯列咬合管理,
小児歯科学雑誌, Vol.47, No.1, 111-118, 2009年3月.

(出版サイトへのリンク): ● Publication site (DOI): 10.11411/jspd.47.1_111
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.11411/jspd.47.1_111

(DOI: 10.11411/jspd.47.1_111) 倉元郁代, 岩﨑智憲, 山崎要一 :
若年者における上顎右側中切歯欠如を伴う叢生歯列の1治験例,
小児歯科学雑誌, Vol.41, No.4, 766-774, 2003年9月.

(出版サイトへのリンク): ● Publication site (DOI): 10.11411/jspd1963.41.4_766
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.11411/jspd1963.41.4_766

(DOI: 10.11411/jspd1963.41.4_766)

特許

岩﨑智憲, 山﨑要一 : 気道通気状態キャリブレーションシステム, 特願16/489311 (2019年8月), . 岩﨑智憲, 山﨑要一 : 気道通気状態キャリブレーションシステム, 特願2019-503110 (2018年3月), . 岩﨑智憲, 山﨑要一 : 歯冠の誤飲・誤嚥防止具, 特願2017-200970 (2017年10月), . 岩﨑智憲, 山﨑要一 : 睡眠時の気道変形予測システム, 特願2016-143249 (2016年7月), . 岩﨑智憲 : 顎顔面部の流体構造連成解析を用いた気道通気状態解析システム, 特願2016-532957 (2015年7月), 特許第6579472号 (2019年9月). 岩﨑智憲, 山﨑要一 : 歯冠の誤飲防止具, 特願2014-075685 (2014年4月), 特許第6433138号 (2018年11月).

作品

幸平若奈, 北村尚正, 前尾慶, 石井瞳, 嘉ノ海龍三, 岩﨑智憲 :
上顎急速拡大にLip Training・MFTを併用することで鼻腔通気障害は改善するか? 鼻粘膜肥厚症例に対して,
小児歯科学雑誌, Vol.60, No.2, 125, 2022年3月. 東條多恵, 河原林啓太, 岩﨑智憲, 吉田雅彦, 東條嶺, 岩本勉 :
急性壊疽性歯髄炎を発症した上顎右側第二小臼歯双生歯の1例,
小児歯科学雑誌, Vol.60, No.2, 58, 2022年2月.

(キーワード): *壊疽(合併症,外科的療法,予後) *歯の奇形(合併症,外科的療法,予後) *歯髄炎(合併症,外科的療法,予後) *上顎骨 *小臼歯 *双生歯(合併症,外科的療法,予後) ヒト青年期(13∼18) 男歯学

岩﨑智憲 :
これまでの上気道流体シミュレーションを用いた研究からみたタイトレーションについて,
睡眠口腔科学, 2020年11月.

(キーワード): 睡眠時無呼吸症候群

岩﨑智憲, 山﨑要一 :
乳歯既成冠の誤飲防止マルカン実用化に係るノウハウ,
鹿児島大学大学院医歯学総合研究科, 2016年5月. 岩﨑智憲 :
気道通気状態検査システム,
鹿児島大学大学院医歯学総合研究科, 2009年2月.

補助金・競争的資金

ダウン症児のCBCTを用いた舌の形態と筋組織ならびに呼吸からみた包括的新規解析 (研究課題/領域番号: 24K13240 )
小児OSAの歯科的治療は漏斗胸を改善するか？－流体力学的研究－ (研究課題/領域番号: 23K09416 )
数値流体力学的解析の導入による先天性気管狭窄症の手術水準向上 (研究課題/領域番号: 23K08307 )
小児鼻腔通気障害に対する歯科的治療法の開拓と治療効果の検討 (研究課題/領域番号: 22K10274 )
CT値から算出した気道周囲組織の物性値を用いた小児OSAの原因部位の特定 (研究課題/領域番号: 20K10230 )
ダウン症児ＯＳＡＳの原因部位特定と上顎側方拡大・ＭＦＴ併用療法の有効性の検討 (研究課題/領域番号: 18K09916 )
小児の睡眠無呼吸時に変動する通気障害部位を検出可能にする気道流体解析モデルの構築 (研究課題/領域番号: 18K09860 )
口腔筋機能療法の小児閉塞性睡眠時無呼吸への有効性が検出可能な流体音響解析法の開発 (研究課題/領域番号: 18K09859 )
小児OSASの新技術で構築された３次元睡眠呼吸モデルによる原因部位の特定 (研究課題/領域番号: 17K11965 )
咀嚼・嚥下機能の新評価法の確立による口唇閉鎖不全と異常口腔機能の関連性の解明 (研究課題/領域番号: 17K11964 )
小児の口唇閉鎖不全は咀嚼・嚥下機能にどのような影響を及ぼすのか？ (研究課題/領域番号: 16K20650 )
小児OSASの上顎側方急速拡大は漏斗胸を予防する－流体構造連成解析を用いて－ (研究課題/領域番号: 16K15841 )
流体解析を応用したダウン症児OSASの部位特定と歯科的治療モデルの構築 (研究課題/領域番号: 16K11864 )
小児の口唇閉鎖力を改善すると咀嚼運動は改善できる (研究課題/領域番号: 16K11802 )
小児における口呼吸が誘発する異常咀嚼・嚥下機能の3次元動態解析 (研究課題/領域番号: 15K20604 )
上気道通気障害小児の過大吸気陰圧は下顎を後退させる－流体構造連成解析を用いて－ (研究課題/領域番号: 26670889 )
小児期気道通気障害による吸気時過大陰圧の漏斗胸原因・増悪因子としての機序解明 (研究課題/領域番号: 25670878 )
乳幼児の捕食動作に関する研究 (研究課題/領域番号: 25463174 )
気道通気障害と口蓋扁桃肥大が小児の咀嚼・嚥下機能におよぼす包括的研究 (研究課題/領域番号: 25293420 )
呼吸様式は「食べ方」に影響するのか？ (研究課題/領域番号: 24792298 )
流体－構造連成解析を用いた小児睡眠時無呼吸症候群の通気障害評価システムの構築 (研究課題/領域番号: 24659914 )
上気道流体シミュレーションによる小児OSASの新しい診断法と歯科的対応法への展開 (研究課題/領域番号: 22792061 )
流体シミュレーションによる小児OSASの通気障害部位の特定と治療予測モデルの構築 (研究課題/領域番号: 22592292 )
仮説:歯列咬合状態から捕食動作は推察できる (研究課題/領域番号: 22592291 )
流体シミュレーション技法による3次元管腔気道形態の通気機能と顎咬合状態の関連評価 (研究課題/領域番号: 22390392 )
小児の睡眠障害およびブラキシズムとストレス、呼吸消化器症状、顎顔面形態との関連 (研究課題/領域番号: 19592361 )
コーンビームX線CTによる小児の気道と顎顔面形態の流体力学的研究 (研究課題/領域番号: 19592360 )
永久歯の先天性欠如に関する総合的研究 (研究課題/領域番号: 19390532 )
研究者番号（10264433）による検索

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2024年12月4日更新

専門分野・研究分野: 小児歯科学 (Pediatric Dentistry)
所属学会・所属協会: 日本小児歯科学会
日本矯正歯科学会
日本障害者歯科学会
日本睡眠学会
日本睡眠歯科学会
日本顎口腔機能学会
成育歯科医療研究会
World Federation of Orthodontists
International Association of Pediatric Dentistry
委員歴・役員歴: 日本小児歯科学会 (理事 [2014年4月〜2016年3月], Pediatric Dental Journal 編集委員 [2012年4月〜2014年3月], 和文誌編集委員会 [2014年4月〜], 研究倫理審査委員会 [2018年4月〜])
日本睡眠歯科学会 (理事学術委員会 [2019年11月〜])
成育歯科医療研究会 (常務理事庶務担当 [2005年8月〜])
受賞: 2008年5月, 第46回日本小児歯科学会大会優秀発表賞 (日本小児歯科学会)
2008年9月, 第67回日本矯正歯科学会大会優秀発表賞 (日本矯正歯科学会)
2010年9月, 第69回日本矯正歯科学会大会優秀発表賞 (日本矯正歯科学会)
2012年6月, 第37回日本睡眠学会大会ベストプレゼンテーション賞 (日本睡眠学会)
2015年5月, 平成26年度日本小児歯科学会学術賞LION AWARD (日本小児歯科学会)
2015年8月, 平成26年度鹿児島大学ベストリサーチャー賞 (鹿児島大学)
2017年5月, 平成28年度日本小児歯科学会町田賞優秀論文賞 (日本小児歯科学会)
2018年10月, 平成29年度鹿児島大学ベストリサーチャー賞 (鹿児島大学)
2019年6月, 第57回日本小児歯科学会大会町田賞優秀発表賞 (日本小児歯科学会)
2019年9月, 日本歯科医学会第35回「歯科医学を中心とした総合的な研究を推進する集い」優秀発表賞 (日本歯科医学会)
2019年11月, 令和元年度鹿児島大学歯学部同窓会奨励賞 (鹿児島大学歯学部同窓会)
2020年5月, 令和元年度日本小児歯科学会町田賞研究奨励賞 (日本小児歯科学会)
2021年7月, 石井町歯科継続健診 (石井町)
2021年9月, ベストプレゼンテーション賞 (日本睡眠学会)
2022年2月, 康楽賞 (徳島大学)
2023年4月, Award for excellent presentation (Korean Academy of Pediatric Dentistry)
活動: 研究者総覧に該当データはありませんでした。

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Ｊグローバル

Jグローバル最終確認日: 2024/11/30 01:24
氏名（漢字）: 岩崎智憲
氏名（フリガナ）: イワサキトモノリ
氏名（英字）: Iwasaki Tomonori
所属機関: 徳島大学医歯薬学研究部教授

リサーチマップ

researchmap最終確認日: 2024/12/1 03:43
氏名（漢字）: 岩崎智憲
氏名（フリガナ）: イワサキトモノリ
氏名（英字）: Iwasaki Tomonori
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2024年11月30日更新

研究者番号: 10264433

所属（現在）: 2024/4/1 : 徳島大学, 大学院医歯薬学研究部(歯学域), 教授

所属（過去の研究課題 情報に基づく）*注記: 2020/4/1 – 2024/4/1 : 徳島大学, 大学院医歯薬学研究部(歯学域), 教授
2015/4/1 – 2020/4/1 : 鹿児島大学, 医歯学域歯学系, 准教授
2015/4/1 : 鹿児島大学, 歯学部, 准教授
2014/4/1 – 2015/4/1 : 鹿児島大学, 医歯(薬)学総合研究科, 准教授
2014/4/1 : 鹿児島大学, 医歯学総合研究科, 准教授
2013/4/1 : 鹿児島大学医歯学附属病院, 小児歯科, 講師
2010/4/1 – 2013/4/1 : 鹿児島大学, 医学部・歯学部附属病院, 講師
2010/4/1 – 2011/4/1 : 鹿児島大学, 附属病院, 講師
2007/4/1 – 2009/4/1 : 鹿児島大学, 大学院・医歯学総合研究科, 助教

審査区分/研究分野

研究代表者

生物系 / 医歯薬学 / 歯学 / 矯正・小児系歯学
小区分57070:成長および発育系歯学関連

研究代表者以外

生物系 / 医歯薬学 / 歯学 / 矯正・小児系歯学
生物系 / 医歯薬学 / 歯学 / 社会系歯学
小区分57070:成長および発育系歯学関連
小区分57080:社会系歯学関連
小区分55040:呼吸器外科学関連

キーワード

研究代表者

小児の気道 / 流体力学 / コーンビームX線CT / 顎顔面形態 / 上気道通気障害 / コーンビームCT / 不正咬合 / 小児 / 気道 / 小児 OSAS / 上気道流体シミュレーション / 上顎骨急速拡大 / 鼻腔通気状態 / 舌位 / 咽頭気道体積 / 歯学 / 睡眠時無呼吸症候群 / 上顎急速拡大 / 小児OSAS / 小児閉塞性睡眠時無呼吸症候群 / 上顎骨急速拡大装置 / CT / airway pressure / Class II / 漏斗胸 / 上気道 / 通気障害 / 小児OSA / 原因部位 / 流体解析 / 3次元モデル / OSA / 小児ＯＳＡＳ / 睡眠呼吸モデル / 口蓋扁桃 / 閉塞性睡眠時無呼吸 / CFD / CT値 / 歯科的治療

研究代表者以外

永久歯 / 先天性欠如 / 疫学調査 / 全国調査 / 発生頻度 / 歯種別 / 小児歯科学 / 発現頻度 / 頻度 / 歯列咬合異常 / 歯学 / 睡眠時無呼吸症候群 / 睡眠障害 / 胃食道酸逆流 / PDSS / SDSC / GERD / 小児 / 睡眠時無呼吸 / 呼吸・消化器症状 / 顎顔面形態 / 睡眠時ブラキシズム / 矯正治療 / 治療効果 / 流体シミュレーション技法 / 顎咬合状態 / 上顎骨急速拡大 / 腔通気状態 / 上顎急速拡大 / 気道通気障害 / 流体シミュレーション / 管腔気道 / 通気圧力 / 通気速度 / CTデータ / 捕食 / 咀嚼 / 歯列形態 / 歯列咬合 / 乳幼児 / 口腔機能 / 咬合 / 歯列 / 動作解析 / 小児OSAS / 上気道流体シミュレーション / 鼻腔通気状態 / 舌位 / 咽頭気道体積 / 小児閉塞性睡眠時無呼吸症候群 / 通気障害部位の特定 / CT / 流体ー構造連成解析 / 通気障害 / 小児睡眠時無呼吸症候群 / 流体構造錬成解析 / 嚥下 / 機能評価 / モーションキャプチャ / 口唇動態 / 舌圧 / 三次元動態解析 / 動態解析 / 口唇運動 / 協調運動 / 口唇閉鎖 / 気道 / 摂食 / 捕食動作 / Motion Capture / 哺乳 / 離乳食 / 顎口腔機能 / 成人 / 成人比較 / airway pressure / Class II / 下顎 / 呼吸 / 下顎後退咬合 / 流体解析 / 不正咬合 / 咀嚼運動 / 下顎運動 / 口唇閉鎖力 / ダウン症候群 / アルツハイマー型認知症 / アミロイドβ / ダウン症 / アミロイドβタンパク / 上顎急速側方拡大 / 口腔筋機能療法 / 舌機能賦活装置 / ダウン症児 / 徐波睡眠 / グリンファティック / 閉塞性睡眠時無呼吸症候群 / Down症候群 / 上顎側方急速拡大 / OSAS改善 / 流体シミュレーション解析 / 歯科的治療モデル / OSAS / 漏斗胸 / 圧力 / 呼気 / 吸気 / 流体構造連成解析 / 協調動態 / 口唇機能評価 / 嚥下動作 / 三次元動作解析 / 口唇閉鎖不全 / モーションキャプチャー / ﾓｰｼｮﾝｷｬﾌﾟﾁｬｼｽﾃﾑ / 口腔内装置 / 閉塞性睡眠時無呼吸 / 流体力学解析 / OSA / 睡眠 / 音響解析 / ＯＳＡＳ / 通気障害部位 / 原因部位 / 睡眠無呼吸 / MFT / 流体力学的解析 / 気管 / 先天性気管狭窄症 / スライド気管形成術 / 気道抵抗 / 小児鼻腔通気障害 / 低位舌 / 鼻粘膜肥厚 / 筋機能訓練 / Hounsfield Unit / SliceOmatic / 鼻腔通気障害 / 小児OSA / 筋機能療法

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岩﨑 智憲

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岩﨑智憲