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羅成圭

徳島大学

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2024年4月30日更新

職名: 准教授
電話: 088-656-9309
電子メール: songgyura@tokushima-u.ac.jp
学歴: 2009/3: 朝鮮大学校体育学部卒業
2011/3: 筑波大学大学院人間総合科学研究科博士前期課程体育学専攻修了
2014/3: 筑波大学大学院人間総合科学研究科 3年制博士課程スポーツ医学専攻修了
学位: 博士(スポーツ医学) (筑波大学) (2014年3月)
職歴・経歴: 2013/4: 日本学術振興会特別研究員DC2(筑波大学大学院)(~2014年3月)
2014/4: 日本学術振興会特別研究員PD(筑波大学体育系，学位取得に伴いDC2から資格変更)(~2015年3月)
2015/4: 日本学術振興会特別研究員PD(筑波大学医学医療系)(~2015年8月)
2015/9: 福岡大学スポーツ科学部助教(~2020年3月)
2016/4: 福岡大学大学院スポーツ健康科学研究科助教(~2020年3月)
2020/4: 徳島大学教養教育院准教授
2022/4: 徳島大学大学院創成科学研究科地域創成専攻准教授(兼任)

専門分野・研究分野: 運動栄養学
運動生理学 (Exercise Physiology)
運動生化学
分子栄養学 (Molecular Nutrition)

研究者総覧で最新データを確認する

2024年4月30日更新

専門分野・研究分野: 運動栄養学
運動生理学 (Exercise Physiology)
運動生化学
分子栄養学 (Molecular Nutrition)
担当経験のある授業科目: ウェルネス総合演習 (共通教育)
スポーツ科学実験実習(運動生理学を含む) (学部)
地域創成特別演習 (大学院)
運動栄養学特論 (大学院)
領域横断セミナー (大学院)
指導経験: 研究者総覧に該当データはありませんでした。

研究者総覧で最新データを確認する

2024年4月30日更新

専門分野・研究分野: 運動栄養学
運動生理学 (Exercise Physiology)
運動生化学
分子栄養学 (Molecular Nutrition)

研究テーマ: タウリンの運動栄養学的機能の解析, 運動と栄養が糖代謝能力に及ぼす影響, 競技パフォーマンス向上のためのスポーツ栄養学, 運動と栄養が循環機能に及ぼす影響, 地域の健康課題を解決するための研究

著書

羅成圭, 川中健太郎 :
5章持久性トレーニングの基礎,
市村出版, 2018年9月. 羅成圭, 大森肇 :
第6章運動時のエネルギー供給機構,
西村書店, 2017年9月.

論文

Song-Gyu RA, Hajime Miura and Takashi Iwata :
Effects of electrical stimulation of the lower extremities on postprandial hyperglycemia and arterial stiffness,
Physical Activity and Nutrition, 2024. 西村里奈, 三浦哉, 羅成圭, 田村靖明, 中村みづき, 久我浩正, 出口純次 :
一過性の自転車こぎ運動と下肢への電気刺激の併用が動脈スティフネスに及ぼす影響,
体力科学, Vol.72, No.6, 371-380, 2023年.

(キーワード): electrical muscle stimulation / arterial stiffness / pulse wave velocity / cycling
(徳島大学機関リポジトリ): ● Metadata: 119135
(出版サイトへのリンク): ● Publication site (DOI): 10.7600/jspfsm.72.371
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390016649288914176; ● Search Scopus @ Elsevier (DOI): 10.7600/jspfsm.72.371

(徳島大学機関リポジトリ: 119135, DOI: 10.7600/jspfsm.72.371, CiNii: 1390016649288914176) Choi Youngju, Song-Gyu RA, Nishijima Takahiko and Maeda Seiji :
Effect of curcumin supplementation on inflammatory status and muscle damage in competitive female soccer players: a placebo-controlled, single-blind, nonrandomized, crossover pilot study,
Physical Activity and Nutrition, Vol.27, No.2, 34-38, 2023.

(出版サイトへのリンク): ● Publication site (DOI): 10.20463/pan.2023.0016
(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-85167683515

(DOI: 10.20463/pan.2023.0016, Elsevier: Scopus) Song-Gyu RA, Hironari Nakagawa, Yuki Tomiga, Hiroki Iizawa, Shihoko Nakashima, Yasuki Higaki and Kentaro Kawanaka :
Effects of dietary vitamin D deficiency on markers of skeletal muscle mitochondrial biogenesis and dynamics,
Journal of Nutritional Science and Vitaminology, Vol.68, No.4, 243-249, 2022.

(要約): We examined the effects of dietary vitamin D deficiency on markers of mitochondrial biogenesis and dynamics in rat soleus muscle. Male Wistar rats were fed a chow with no vitamin D (No-D; 0 IU/kg) or a moderate dose (Mod-D; 2,000 IU/kg) of vitamin D chow for 8 wk. Compared to the Mod-D group, at 8 wk the No-D group showed significantly lower serum 25(OH)D levels. Although vitamin D deficiency had no effect on body composition, the No-D rats showed significantly decreased levels of PGC-1α, a marker of skeletal muscle mitochondrial biogenesis, and DRP1, a marker of skeletal muscle mitochondrial fission. The change in the PGC-1α protein expression and the serum 25(OH)D concentrations were significantly correlated. The change in DRP1 protein expression and the serum 25(OH)D concentrations tended to be correlated. There was no significant between-group difference in markers of mitochondrial fusion (MFN2 and OPA1) and mitophagy (PARKIN) in soleus muscle, and no relationship with serum 25(OH)D concentrations. Collectively our findings suggest that dietary vitamin D deficiency decreased PGC-1α and DRP1 protein expression in rat soleus muscle.
(出版サイトへのリンク): ● Publication site (DOI): 10.3177/jnsv.68.243
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36047095; ● Search Scopus @ Elsevier (PMID): 36047095; ● Search Scopus @ Elsevier (DOI): 10.3177/jnsv.68.243

(DOI: 10.3177/jnsv.68.243, PubMed: 36047095) Kaname Tagawa, Song-Gyu RA, Toru Yoshikawa and Seiji Maeda :
Eccentric exercise improves myocardial oxygen supply/demand balance with decelerating aortic diastolic pressure decay: the acute and chronic studies,
European Journal of Sport Science, Vol.23, No.1, 92-100, 2022.

(要約): Both eccentric (ECC) and concentric (CON) exercises improve energy expenditure and blood lipid profile. Although ECC exercise has a more beneficial effect on these factors than CON exercise, its benefits on vital organs are still unclear. This study investigated the mode-of-action-dependent effects on myocardial perfusion index. Seventeen healthy men (age: 26 ± 5 years) were randomly enrolled in CON ( = 9) and ECC ( = 8) groups. Transient exercise and regular training (three-day a week for 4-week) included bicep curl comprising 5-set of 10-repetition, each using 75% one-repetition maximum concentric loading. The ECC group performed one-repetition of ECC for 3-s and CON for 1-s, while the CON group performed one-repetition of CON for 3-s and ECC for 1-s. All participants were assessed for subendocardial viability ratio (SEVR, myocardial perfusion index) and aortic diastolic pressure decay. Before study, these were found to be same for both groups. Transient (ΔSEVR: 20.3 ± 13.3%, = 0.01; Δdecay: -0.07 ± 0.02 s, < .001) and regular (ΔSEVR: 18.5 ± 12.8%, = .001; Δdecay: -0.06 ± 0.05 s, = .004) ECC (but not CON) exercises significantly increased SEVR and decelerated decay. Increased SEVR with ECC exercise was associated with decelerated decay (transient ECC: = 0.56, 95% confidence interval [CI] = -0.95 to -0.10, = .03; regular ECC: = 0.53, 95% CI = -0.95 to -0.05, = .04). These findings suggest that ECC exercise improves myocardial perfusion and diastolic pressure contour is involved in physiological mechanisms.
(出版サイトへのリンク): ● Publication site (DOI): 10.1080/17461391.2021.2025268
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34974818; ● Search Scopus @ Elsevier (PMID): 34974818; ● Search Scopus @ Elsevier (DOI): 10.1080/17461391.2021.2025268

(DOI: 10.1080/17461391.2021.2025268, PubMed: 34974818) Kohei Kido, Keiichi Koshinaka, Hiroki Iizawa, Hiroki Honda, Ayumu Hirota, Taishi Nakamura, Miku Arikawa, Song-Gyu RA and Kentaro Kawanaka :
Egg white protein promotes developmental growth in rodent muscle independent of the leucine content,
The Journal of Nutrition, Vol.152, No.1, 117-129, 2022.

(要約): Leucine has unique anabolic properties, serving as a nutrient signal that stimulates muscle protein synthesis. We tested whether the leucine concentration is the only factor determining protein quality for muscle development. We selected 3 dietary proteins: casein (CAS), egg white protein (EWP), and albumin (ALB), representing the leucine concentrations of ∼8.3%, 7.7%, and 6.7% of the total protein (wt:wt), respectively. In the chronic feeding experiment, these proteins were pair-fed to growing male Wistar rats [110-135 g body weight (BW)] for 14 d as a protein source, providing 10% of total energy intake, after which soleus and extensor digitorum longus (EDL) muscles were used to estimate muscle growth. In the acute administration experiment, we injected CAS, ALB, and EWP to rats by oral gavage (0.3 g protein/100 g BW), and after 1 or 3 h EDL muscle was excised for capillary electrophoresis-MS-based metabolomics. In another chronic feeding experiment, rats were pair-fed either CAS or a CAS diet supplemented with arginine to the same level as in the EWP diet for 14 d. At the end of the 14-d feeding, soleus and EDL muscle weight was 20% and 17% higher, respectively, when rats were fed EWP as compared with CAS (P < 0.05). In addition, the 14-d EWP diet increased the expression of p70S6K by 117% compared with CAS (P < 0.05). These results suggest the possibility that some amino acids (excluding leucine), derived from EWP, promote muscle growth. Metabolomics analysis showed that muscle arginine concentration, following acute protein administration, appeared to match muscle growth over the 14-d feeding period. In addition, 14-d arginine supplementation to a CAS diet increased EDL muscle weight by 15% when compared with the plain CAS diet (P < 0.05). EWP promotes rat developmental muscle growth compared with CAS, which can be partly explained by the arginine-rich EWP.
(キーワード): Animals / Egg Proteins / Leucine / Male / Muscle Proteins / Muscle, Skeletal / Rats / Rats, Wistar / Rodentia
(出版サイトへのリンク): ● Publication site (DOI): 10.1093/jn/nxab353
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34610138; ● Search Scopus @ Elsevier (PMID): 34610138; ● Search Scopus @ Elsevier (DOI): 10.1093/jn/nxab353

(DOI: 10.1093/jn/nxab353, PubMed: 34610138) Teruo Miyazaki, Yuho Nakamura-Shinya, Kei Ebina, Shoichi Komine, Song-Gyu RA, Keisuke Ishikura, Hajime Ohmori and Akira Honda :
N-aceytyltaurine and acetylcarnitine production for the mito-chondrial acetyl-CoA regulation in skeletal muscles during endurance exercise,
Metabolites, Vol.11, No.8, 522, 2021.

(徳島大学機関リポジトリ): ● Metadata: 116599
(出版サイトへのリンク): ● Publication site (DOI): 10.3390/metabo11080522
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.3390/metabo11080522

(徳島大学機関リポジトリ: 116599, DOI: 10.3390/metabo11080522) Yuki Tomiga, Kazuya Sakai, Song-Gyu RA, Masaki Kusano, Ai Ito, Yoshinari Uehara, Hirokazu Takahashi, Kentaro Kawanaka, Hidenobu Soejima and Yasuki Higaki :
Short-term running exercise alters DNA methylation patterns in nNOS and BDNF genes in the mouse hippocampus and reduces anxiety-like behaviors,
The FASEB journal, Vol.35, No.8, e21767, 2021.

(要約): Running exercise has beneficial effects on brain health. However, the effects of relatively short-term running exercise (STEx) on behavior, and its underlying signaling pathways, are poorly understood. In this study, we evaluated the possibility that the regulation by STEx of brain-derived neurotrophic factor (BDNF) and neuronal nitric oxide synthase (nNOS, encoded by NOS1), which are important molecules for anxiety regulation, might involve mechanisms of epigenetic modification, such as DNA methylation. C57BL/6J male mice were divided into sedentary (SED, n = 12) and STEx (EX, n = 15) groups; STEx was conducted with the mice for a duration of 11 days. STEx reduced anxiety-like behaviors, and STEx reduced Nos1α and increased Bdnf exon I and IV mRNA levels in the hippocampus. Interestingly, behavioral parameters were associated with Bdnf exon I and IV and Nos1α mRNA levels in the ventral, but not dorsal, hippocampal region. However, STEx had no effect on peroxisome proliferator-activated receptor-γ coactivator 1α (Pgc-1α) or fibronectin type III domain-containing 5 (Fndc5) mRNA levels, which are relatively long-term exercise-induced upstream regulators of BDNF. In parallel with gene expression changes, we found, for the first time, that STEx downregulated Bdnf promoter IV and upregulated Nos1 DNA methylation levels in the hippocampus, and these patterns were partially different between the dorsal and ventral regions. These findings suggest that the beneficial effects of running exercise on mood regulation may be controlled by alterations in epigenetic mechanisms, especially in the ventral hippocampus. These effects occur even after a relatively short-term period of exercise.
(キーワード): Adipose Tissue / Animals / Anxiety / Behavior, Animal / Body Composition / Body Weight / Brain-Derived Neurotrophic Factor / DNA Methylation / Fibronectins / Hippocampus / Male / Mice / Mice, Inbred C57BL / Nitric Oxide Synthase Type I / Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha / Physical Conditioning, Animal / RNA, Messenger / Random Allocation / Running / Time Factors
(出版サイトへのリンク): ● Publication site (DOI): 10.1096/fj.202100630R
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34325488; ● Search Scopus @ Elsevier (PMID): 34325488; ● Search Scopus @ Elsevier (DOI): 10.1096/fj.202100630R

(DOI: 10.1096/fj.202100630R, PubMed: 34325488) 出口純次, 三浦哉, 田村靖明, 石川みづき, 村上亜弥子, 羅成圭 :
課題前の有酸素性運動が筋力発揮調整能に及ぼす影響,
理学療法科学, Vol.36, No.3, 453-456, 2021年.

(要約): <p>〔目的〕課題前の有酸素性運動が筋力発揮調整能に及ぼす効果について検討した．〔対象と方法〕対象者は，健常成人15名であり，すべての対象者は60%VO<sub>2 max</sub>で10分間の自転車こぎ運動(aerobic exercise:AE)条件および安静座位のコントロール(control:CON)条件の2条件をランダムで実施した．筋力発揮調整能テストは，7つの強度をそれぞれ8回，計56回を無作為に実施した．〔結果〕AE条件における筋力発揮調整能の成功数は，実施1時間後および24時間後に実施前と比較して有意に増加した．CON条件では実施前と比較して有意な変化は認められなかった．〔結語〕課題前の有酸素性運動は筋力発揮調整能の促進および保持を向上させる可能性がある．</p>
(キーワード): 筋力発揮調整能 / 有酸素性運動 / 課題前
(徳島大学機関リポジトリ): ● Metadata: 117263
(出版サイトへのリンク): ● Publication site (DOI): 10.1589/rika.36.453
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390006973365876736; ● Search Scopus @ Elsevier (DOI): 10.1589/rika.36.453

(徳島大学機関リポジトリ: 117263, DOI: 10.1589/rika.36.453, CiNii: 1390006973365876736) Kaname Tagawa, Song-Gyu RA, Youngju Choi, Toru Yoshikawa, Hiroshi Kumagai and Seiji Maeda :
Regular resistance training favorably affects central artery stiffness response following transient resistance exercise,
Sport Sciences for Health, Vol.17, No.1, 901-909, 2021.

(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s11332-021-00748-5
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1007/s11332-021-00748-5

(DOI: 10.1007/s11332-021-00748-5) Youngju Choi, Nobuhiko Akazawa, Asako Zempo-Miyaki, Song-Gyu RA and Seiji Maeda :
Sleep quality is associated with central arterial stiffness in postmenopausal women: a cross-sectional pilot study,
Artery Research, Vol.27, No.1, 14-19, 2021.

(徳島大学機関リポジトリ): ● Metadata: 116271
(出版サイトへのリンク): ● Publication site (DOI): 10.2991/artres.k.201004.001
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.2991/artres.k.201004.001

(徳島大学機関リポジトリ: 116271, DOI: 10.2991/artres.k.201004.001) Kaname Tagawa, Youngju Choi, Song-Gyu RA, Toru Yoshikawa, Hiroshi Kumagai and Seiji Maeda :
Stature is negatively associated with increased arterial stiffness after high-intensity bicep curls training in young Japanese men,
European Journal of Sport Science, Vol.22, No.7, 1104-1112, 2021.

(要約): Reports have indicated that high-intensity resistance training (RT) increases or does not change arterial stiffness. Meanwhile, higher stature has been suggested to have a protective effect on cardiovascular disease and arterial stiffness. Stature could explain the disagreement in the reported effects of RT on arterial stiffness. This study was aimed at investigating whether stature is related to RT-induced change in arterial stiffness. Thirty-six young Japanese men were assigned to the control ( = 15) and training groups ( = 21). RT programme consisted of supervised bicep curls 3 days per week for 4 weeks (5 sets of 10 repetitions at 75% of 1-repetition maximum). Arterial compliance (AC) and β-stiffness index (via combination of ultrasound and carotid pressure waveforms) were measured in all participants. To verify the effect of stature on RT-induced change in arterial stiffness, the training group was divided into tertiles of stature: lower, middle, and higher stature groups (each group, = 7). RT significantly decreased AC and increased β-stiffness index in only the lower stature group (both, < 0.05). Moreover, stature was positively associated with decreased AC and negatively associated with increased β-stiffness index, even after adjusting for confounders including changes in relative strength, pulse pressure, and arterial distension ( < 0.05). The present results suggest that short stature contributes to the increase in arterial stiffness induced by RT in young Japanese men. The present findings suggest that stature should be taken into consideration when designing/engaging in RT programme, due to potential implications for cardiovascular health. Participants were divided into 3 groups according to tertiles of statures, and arterial stiffness of lower stature group (range of stature: 161.0-169.8 cm) increased after resistance training in young Japanese men, but not middle and higher stature group.Stature was negatively associated with the changed arterial stiffness by resistance training.This study suggests that short stature contributes to the elevation in arterial stiffness elicited by resistance training.
(出版サイトへのリンク): ● Publication site (DOI): 10.1080/17461391.2021.1900402
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33673788; ● Search Scopus @ Elsevier (PMID): 33673788; ● Search Scopus @ Elsevier (DOI): 10.1080/17461391.2021.1900402

(DOI: 10.1080/17461391.2021.1900402, PubMed: 33673788) 時野谷勝幸, 石倉惠介, 羅成圭, 海老名慧, 宮川俊平, 大森肇 :
アマチュアランナーにおけるフルマラソン後の血中酸化ストレス評価 -d-ROMおよびBAPテストを用いた検証-,
大学体育研究, Vol.43, 13-20, 2021年. Shoichi Komine, Teruo Miyazaki, Keisuke Ishikura, Takashi Matsui, Takashi Miyoshi, Song-Gyu RA, Akira Honda, Hideaki Soya, Shumpei Miyakawa and Hajime Ohmori :
Taurine supplementation enhances endurance capacity by delaying blood glucose decline during prolonged exercise in rats,
Amino Acids, Vol.54, No.2, 251-260, 2021.

(要約): Taurine enhances physical performance; however, the underlying mechanism remains unclear. This study examined the effect of taurine on the overtime dynamics of blood glucose concentration (BGC) during endurance exercise in rats. Male F344 rats were subjected to transient treadmill exercise until exhaustion following 3 weeks of taurine supplementation or non-supplementation (TAU and CON groups). Every 10 min during exercise, BGC was measured in blood collected through cannulation of the jugular vein. Gluconeogenesis-, lipolysis-, and fatty acid oxidation-related factors in the plasma, liver, and skeletal muscles were also analyzed after 120-min run. Exercise time to exhaustion was significantly longer with taurine supplementation. BGC in the two groups significantly increased by 40 min and gradually and significantly decreased toward the respective exhaustion point. The decline in BGC from the peak at 40 min was significantly slower in the TAU group. The time when the once-increased BGC regressed to the 0-time level was significantly and positively correlated with exercise time until exhaustion. At the 120-min point, where the difference in BGC between the two groups was most significant, plasma free fatty acid concentration and acetyl-carnitine and N-acetyltaurine concentrations in skeletal muscle were significantly higher in the TAU group, whereas glycogen and glucogenic amino acid concentrations and G6Pase activity in the liver were not different between the two groups. Taurine supplementation enhances endurance capacity by delaying the decrease in BGC toward exhaustion through increases of lipolysis in adipose tissues and fatty acid oxidation in skeletal muscles during endurance exercise.
(キーワード): Animals / Blood Glucose / Dietary Supplements / Male / Muscle, Skeletal / Physical Endurance / Rats / Rats, Inbred F344 / Taurine
(徳島大学機関リポジトリ): ● Metadata: 117208
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s00726-021-03110-8
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35122528; ● Summary page in Scopus @ Elsevier: 2-s2.0-85124289788

(徳島大学機関リポジトリ: 117208, DOI: 10.1007/s00726-021-03110-8, PubMed: 35122528, Elsevier: Scopus) Katsuyuki Tokinoya, Keisuke Ishikura, Yasuko Yoshida, Song-Gyu RA, Takehito Sugasawa, Atsushi Aoyagi, Yoshiharu Nabekura, Kazuhiro Takekoshi and Hajime Ohmori :
LDH isoenzyme 5 is an index of early onset muscle soreness (EOMS) during prolonged running.,
The Journal of Sports Medicine and Physical Fitness, Vol.60, No.7, 1020-1026, 2020.

(要約): EOMS started to occur at 20 km during a 30 km running task. Our data suggest that LDH isoenzyme 5 is a marker of occurrence in EOMS during prolonged running.
(出版サイトへのリンク): ● Publication site (DOI): 10.23736/S0022-4707.20.10278-0
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32253893; ● Search Scopus @ Elsevier (PMID): 32253893; ● Search Scopus @ Elsevier (DOI): 10.23736/S0022-4707.20.10278-0

(DOI: 10.23736/S0022-4707.20.10278-0, PubMed: 32253893) Song-Gyu RA, Emi Kawamoto, Keiichi Koshinaka, Maiko Iwabe, Yuki Tomiga, Hiroki Iizawa, Hiroki Honda, Yasuki Higaki and Kentaro Kawanaka :
Acute bout of exercise downregulates thioredoxin-interacting protein expression in rat contracting skeletal muscles.,
Physiological Reports, Vol.8, No.11, e14388, 2020.

(要約): We previously reported that in rat skeletal muscle, disuse (i.e., decreased muscle contractile activity) rapidly increases thioredoxin-interacting protein (TXNIP), which is implicated in the reduced glucose uptake. Accordingly, we sought herein to (a) determine the effect of exercise (i.e., increased muscle contractile activity) on muscle TXNIP protein expression, and (b) elucidate the mechanisms underlying the changes of TXNIP protein expression in response to exercise. Rat epitrochlearis and soleus muscles were dissected out after an acute bout of 3-hr swimming (without weight loading) or 3-hr treadmill running (15% grade at 9m/min). In a separate protocol, the isolated epitrochlearis and soleus muscles were incubated for 3 hr with AMP-dependent protein kinase activator AICAR. Immediately after the cessation of the 3-hr swimming, the TXNIP protein was decreased in epitrochlearis but not in soleus muscle. Conversely, 3-hr treadmill running decreased the TXNIP protein in soleus but not in epitrochlearis muscle. TXNIP protein was decreased concomitantly with reduced postexercise muscle glycogen, showing that a decrease in TXNIP protein expression occurs in muscles that are recruited during exercise. In addition, 3-hr incubation with AICAR decreased TXNIP protein in both isolated epitrochlearis and soleus muscles. Our results suggest that (a) an acute bout of exercise downregulates TXNIP protein expression in rat contracting skeletal muscles, and (b) the reduction in TXNIP protein expression in contracting muscles is probably mediated by AMPK activation, at least in part.
(徳島大学機関リポジトリ): ● Metadata: 116142
(出版サイトへのリンク): ● Publication site (DOI): 10.14814/phy2.14388
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32476292; ● Search Scopus @ Elsevier (PMID): 32476292; ● Search Scopus @ Elsevier (DOI): 10.14814/phy2.14388

(徳島大学機関リポジトリ: 116142, DOI: 10.14814/phy2.14388, PubMed: 32476292) Katsuyuki Tokinoya, Keisuke Ishikura, Song-Gyu RA, Kei Ebina, Shumpei Miyakawa and Hajime Ohmori :
Relationship between early-onset muscle soreness and indirect muscle damage markers and their dynamics after a full marathon.,
Journal of Exercise Science and Fitness, Vol.18, No.3, 115-121, 2020.

(要約): Muscle soreness peaked and muscle damage markers in the blood showed different dynamics after a full marathon. In other words, this is different from DOMS.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jesf.2020.03.001
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32351588; ● Search Scopus @ Elsevier (PMID): 32351588; ● Search Scopus @ Elsevier (DOI): 10.1016/j.jesf.2020.03.001

(DOI: 10.1016/j.jesf.2020.03.001, PubMed: 32351588) Yuki Tomiga, Saki Yoshimura, Song-Gyu RA, Yuri Takahashi, Rina Goto, Ikumi Kugimoto, Yoshinari Uehara, Kentaro Kawanaka and Yasuki Higaki :
Anxiety-like behaviors and hippocampal nNOS in response to diet-induced obesity combined with exercise.,
The Journal of Physiological Sciences, Vol.69, No.5, 711-722, 2019.

(要約): A high-fat diet (HFD) and overweight status can induce hippocampal dysfunction, leading to depression and anxiety. Exercise has beneficial effects on emotional behaviors. We previously reported that exercise training rescues HFD-induced excess hippocampal neuronal nitric oxide synthase (nNOS) expression, which is a key regulator of anxiety. Here, we investigated anxiety-like behaviors and hippocampal nNOS expression in response to HFD combined with exercise. Mice were assigned to standard diet, HFD, or HFD with exercise groups for 12 weeks. We found that exercise during the final 6 weeks of the HFD regime improved 12 weeks of HFD-induced defecation, accompanied by rescue of excess nNOS expression. However, anxiety indicators in the elevated plus maze were unchanged. These effects were not apparent after only 1 week of exercise. In conclusion, 6 weeks of exercise training reduced HFD-related anxiety according to one of our measures (defecation), and reversed changes in the hippocampal nNOS/NO pathway.
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s12576-019-00686-5
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31124076; ● Search Scopus @ Elsevier (PMID): 31124076; ● Search Scopus @ Elsevier (DOI): 10.1007/s12576-019-00686-5

(DOI: 10.1007/s12576-019-00686-5, PubMed: 31124076) Song-Gyu RA, Youngju Choi, Nobuhiko Akazawa, Kentaro Kawanaka, Hajime Ohmori and Seiji Maeda :
Effects of Taurine Supplementation on Vascular Endothelial Function at Rest and After Resistance Exercise.,
Advances in Experimental Medicine and Biology, Vol.1155, 407-414, 2019.

(要約): High-intensity resistance exercise has been shown to increase arterial stiffness and reduce vascular endothelial function. Taurine supplementation has a favorable effect on maintaining vascular function. We had previously reported that taurine supplementation attenuated increases in resistance exercise-induced arterial stiffness. In the present study, we further investigate the effects of taurine supplementation on vascular endothelial function at rest and after resistance exercise.Twenty-nine healthy men were recruited and randomly assigned to either the placebo supplement group (n=14) or the taurine supplement group (n=15) in a double-blinded manner. Subjects were required to ingest 6g of either a placebo or the taurine supplement for 2weeks prior to and 3days following the exercise. Two weeks after the commencement of supplementation, the subjects were asked to perform 2 sets of 20 repetitive unilateral maximal-effort resistance exercise of the elbow flexors on a Biodex isokinetic dynamometer, with each contraction lasting 3s, with 1 repetition performed every 9s and 4 min rest in between sets. We evaluated the changes in brachial artery flow-mediated dilation (FMD) in the non-exercised arm as an index of vascular endothelial function. Relative and absolute FMDs were measured prior to supplementation, before exercise, and 24, 48, and 96h after exercise.Two weeks of taurine supplementation significantly increased both relative and absolute FMDs. Baseline diameter significantly increased at 96h following the exercise in both groups. However, there was no change in the peak diameter. Consequently, both relative and absolute FMDs were significantly reduced at 96h after the exercise in both groups. Taurine supplementation does not affect resistance exercise-induced reduction in FMD.Two weeks of taurine supplementation (6g/day) significantly increased vascular endothelial function at rest; however, taurine supplementation did not improve resistance exercise-induced reduction in FMD.
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/978-981-13-8023-5_38
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31468418; ● Search Scopus @ Elsevier (PMID): 31468418; ● Search Scopus @ Elsevier (DOI): 10.1007/978-981-13-8023-5_38

(DOI: 10.1007/978-981-13-8023-5_38, PubMed: 31468418) Song-Gyu RA, Teruo Miyazaki, Ryo Kojima, Shoichi Komine, Keisuke Ishikura, Kentaro Kawanaka, Akira Honda, Yasushi Matsuzaki and Hajime Ohmori :
Effect of BCAA supplement timing on exercise-induced muscle soreness and damage: a pilot placebo-controlled double-blind study.,
The Journal of Sports Medicine and Physical Fitness, Vol.58, No.11, 1582-1591, 2018.

(要約): The present study confirmed that repeated BCAA supplementation before exercise had a more beneficial effect in attenuating DOMS and EIMD induced by eccentric exercise than repeated supplementation after exercise.
(出版サイトへのリンク): ● Publication site (DOI): 10.23736/S0022-4707.17.07638-1
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28944645; ● Search Scopus @ Elsevier (PMID): 28944645; ● Search Scopus @ Elsevier (DOI): 10.23736/S0022-4707.17.07638-1

(DOI: 10.23736/S0022-4707.17.07638-1, PubMed: 28944645) Kaname Tagawa, Song-Gyu RA, Hiroshi Kumagai, Yuriko Sawano, Kosaku Yamamoto, Toru Yoshikawa, Youngju Choi, Yasuko Yoshida, Kazuhiro Takekoshi and Seiji Maeda :
Resistance training-induced decreases in central arterial compliance is associated with increases in serum thromboxane B2 concentrations in young men,
Artery Research, Vol.23, No.C, 63-70, 2018.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.artres.2018.08.001
(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-85052907997

(DOI: 10.1016/j.artres.2018.08.001, Elsevier: Scopus) Kaname Tagawa, Song-Gyu RA, Hiroshi Kumagai, Toru Yoshikawa, Yasuko Yoshida, Kazuhiro Takekoshi, S Sakai, Takashi Miyauchi and Seiji Maeda :
Effects of resistance training on arterial compliance and plasma endothelin-1 levels in healthy men.,
Physiological Research / Academia Scientiarum Bohemoslovaca, Vol.67, No.Suppl 1, S155-S166, 2018.

(要約): Arterial compliance (AC) is an index of the elasticity of large arteries. Endothelial dysfunction has been reported to result in reduced arterial compliance, which represents increased arterial stiffness. A reduction in AC is elicited by high-intensity resistance training, however the mechanisms are obscure. Because a single bout of resistance exercise causes a transient increase in circulating plasma endothelin-1 in humans, some vasoconstrictors may play a role in the mechanisms. The present study aimed to investigate whether resistance training-induced decrease in AC is associated with changes in circulating vasoconstrictors levels in young men. Young sedentary men were assigned to control (n=5) or training (n=9) groups. The training group performed four-week high-intensity resistance training (weight training exercise; three sessions/week). We measured AC and plasma levels of endothelin-1, angiotensin II, and norepinephrine before and after intervention. Resistance training significantly decreased AC, whereas the changes in plasma levels of neither endothelin-1, nor angiotensin II, nor norepinephrine were significantly different between the control and the training groups. Moreover, we found no significant correlations between changes in circulating plasma levels (endothelin-1, angiotensin II, and norepinephrine) and in the AC. Despite of no alteration of the resting circulating plasma levels (endothelin-1, etc.), we cannot exclude a possibility that the tissue/local concentrations of vasoconstrictors (endothelin-1, etc.) around the vessels might be increased and also involved in a reduction of AC in the training group. Taken together, the present results suggest that circulating vasoconstrictors (endothelin-1, etc.) in plasma are not involved in a reduction in AC by the resistance training.
(出版サイトへのリンク): ● Publication site (DOI): 10.33549/physiolres.933818
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29947536; ● Search Scopus @ Elsevier (PMID): 29947536; ● Search Scopus @ Elsevier (DOI): 10.33549/physiolres.933818

(DOI: 10.33549/physiolres.933818, PubMed: 29947536) Song-Gyu RA, Kaname TAGAWA, Youngju CHOI and Seiji MAEDA :
Hemodynamic response to unilateral resistance exercise with lactotripeptides,
Gazzetta Medica Italiana Archivio per le Scienze Mediche, Vol.177, No.6, 277-283, 2018.

(出版サイトへのリンク): ● Publication site (DOI): 10.23736/S0393-3660.17.03631-2
(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-85048494846

(DOI: 10.23736/S0393-3660.17.03631-2, Elsevier: Scopus) Emi Kawamoto, Keigo Tamakoshi, Song-Gyu RA, Hiroyuki Masuda and Kentaro Kawanaka :
Immobilization rapidly induces thioredoxin-interacting protein gene expression together with insulin resistance in rat skeletal muscle.,
Journal of Applied Physiology, Vol.125, No.2, 596-604, 2018.

(要約): Acute short duration of disuse induces the development of insulin resistance for glucose uptake in rodent skeletal muscle. Because thioredoxin-interacting protein (TXNIP) has been implicated in the downregulation of insulin signaling and glucose uptake, we examined the possibility that muscle disuse rapidly induces insulin resistance via increased TXNIP mRNA and protein expression. Male Wistar rats were subjected to unilateral 6-h hindlimb immobilization by plaster cast. At the end of this period, the soleus muscles from both immobilized and contralateral nonimmobilized hindlimbs were excised and examined. The 6-h immobilization resulted in an increase in TXNIP mRNA and protein expressions together with a decrease in insulin-stimulated 2-deoxyglucose uptake in the rat soleus muscle. Additionally, in the rats euthanized 6 h after the plaster cast removal, TXNIP protein expression and insulin-stimulated glucose uptake in the immobilized muscle had both been restored to a normal level. Various interventions (pretreatment with transcription inhibitor actinomycin D or AMP-dependent protein kinase activator 5-aminoimidazole-4-carboxamide ribonucleotide) also suppressed the increase in TXNIP protein expression in 6-h-immobilized muscle together with partial prevention of insulin resistance for glucose uptake. These results suggested the possibility that increased TXNIP protein expression in immobilized rat soleus muscles was associated with the rapid induction of insulin resistance for glucose uptake in that tissue. NEW & NOTEWORTHY The cellular mechanism by which disuse rapidly induces muscle insulin resistance for glucose uptake remains to be identified. Using a rat hindlimb immobilization model, our findings suggest the possibility that transcriptional upregulation of thioredoxin-interacting protein is associated with the immobilization-induced rapid development of insulin resistance in skeletal muscle.
(出版サイトへのリンク): ● Publication site (DOI): 10.1152/japplphysiol.00951.2017
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29792552; ● Search Scopus @ Elsevier (PMID): 29792552; ● Search Scopus @ Elsevier (DOI): 10.1152/japplphysiol.00951.2017

(DOI: 10.1152/japplphysiol.00951.2017, PubMed: 29792552) Kaname Tagawa, Song-Gyu RA, Youngju Choi and Seiji Maeda :
Lactotripeptides Supplementations Alleviate the Decrease in Maximal Isometric Force After High-Intensity Eccentric Exercise: A Randomized, Placebo-Controlled, Double-Blind Clinical Trial.,
American Journal of Physical Medicine & Rehabilitation, Vol.97, No.5, 370-374, 2018.

(要約): The present results suggest that lactotripeptides supplementation alleviates the decrease in the maximal isometric force via an increase in brachial arterial diameter after ECC.
(出版サイトへのリンク): ● Publication site (DOI): 10.1097/PHM.0000000000000867
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29189308; ● Search Scopus @ Elsevier (PMID): 29189308; ● Search Scopus @ Elsevier (DOI): 10.1097/PHM.0000000000000867

(DOI: 10.1097/PHM.0000000000000867, PubMed: 29189308) Nobuhiko Akazawa, Koichiro Tanahashi, Keisei Kosaki, Song-Gyu RA, Tomoko Matsubara, Youngju Choi, Asako Zempo-Miyaki and Seiji Maeda :
Aerobic exercise training enhances cerebrovascular pulsatility response to acute aerobic exercise in older adults.,
Physiological Reports, Vol.6, No.8, e13681, 2018.

(要約): The brain's low resistance ensures a robust blood flow throughout systole and diastole and is susceptible to flow pulsatility. Increased cerebral pulsatility contributes to the progression of cerebrovascular disease. Although aerobic exercise affects vascular function, little is known about the effect of exercise on the cerebral pulsatility index in older adults. The aim of this study was to investigate the effect of exercise training on the post-exercise cerebral pulsatility response in older adults. Ten healthy older adults participated in a 12-week exercise training intervention. Before and after the intervention, we measured the pulsatility index of the middle cerebral artery by means of transcranial Doppler method at baseline and following a cycling exercise bout performed at an intensity corresponding to the ventilatory threshold. Before exercise training, there was no significant change in the cerebral pulsatility response to an acute bout of cycling exercise. However, after the intervention, cerebral pulsatility decreased significantly following 30 min of an acute cycling exercise (P < 0.05). This study demonstrated that cerebral pulsatility index did not change following an acute bout of cycling exercise at an intensity corresponding to ventilatory threshold, but that, after 12 weeks of exercise training, cerebral pulsatility index was reduced at 30 min after a single bout of cycling exercise. These results suggest that long-term aerobic exercise training may enhance the post-exercise reduction in pulsatility index in older adults.
(出版サイトへのリンク): ● Publication site (DOI): 10.14814/phy2.13681
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29687959; ● Search Scopus @ Elsevier (PMID): 29687959; ● Search Scopus @ Elsevier (DOI): 10.14814/phy2.13681

(DOI: 10.14814/phy2.13681, PubMed: 29687959) 石倉恵介, 小峰昇一, 羅成圭, 宮﨑照雄, 宮川俊平, 吉岡利貢, 鍋倉賢治, 大森肇 :
分岐鎖アミノ酸(BCAA)摂取がマラソン後の血清C反応性タンパク質濃度ならびに血漿グルタミン濃度に及ぼす効果,
ランニング学研究 = Journal of running science, Vol.29, No.2, 157-165, 2018年.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1520572359382196736

(CiNii: 1520572359382196736) Kaname Tagawa, Youngju Choi, Song-Gyu RA, Toru Yoshikawa, Hiroshi Kumagai and Seiji Maeda :
Resistance training-induced decrease in central arterial compliance is associated with decreased subendocardial viability ratio in healthy young men.,
Applied Physiology, Nutrition, and Metabolism, Vol.43, No.5, 510-516, 2017.

(要約): High-intensity resistance training decreases central arterial compliance (CAC). Subendocardial viability ratio (SEVR) is a useful tool that reflects the balance between coronary perfusion and left ventricular afterload. Animal studies have demonstrated that decreased CAC is associated with SEVR deterioration. Therefore, resistance training-induced decrease in CAC may be associated with changes in SEVR. The objective of the present study was to investigate the association between SEVR and CAC using both cross-sectional and longitudinal (i.e., resistance training) study designs. To achieve this, we first conducted a cross-sectional study to investigate the association between SEVR and CAC in 89 young men. Thereafter, a longitudinal study was performed to examine the effects of resistance training on SEVR and CAC in young men. A total of 28 young men were divided into 2 groups: control (n = 13) and training (n = 15). In the training group, subjects underwent supervised resistance training for 4 weeks (5 sets of 10 repetitions at 75% of 1-repetition maximum, 3 times/week). CAC and SEVR were then measured in all subjects. In the cross-sectional study, SEVR was significantly positively correlated with CAC, whereas resistance training significantly decreased both SEVR and CAC. Moreover, training-induced changes in CAC were significantly correlated with changes in SEVR. Thus, these results suggest that resistance training-induced decrease in CAC is associated with decreased SEVR in young men.
(出版サイトへのリンク): ● Publication site (DOI): 10.1139/apnm-2017-0449
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29253352; ● Search Scopus @ Elsevier (PMID): 29253352; ● Search Scopus @ Elsevier (DOI): 10.1139/apnm-2017-0449

(DOI: 10.1139/apnm-2017-0449, PubMed: 29253352) Keisei Kosaki, A Kamijo-Ikemori, T Sugaya, Koichiro Tanahashi, Y Sawano, Nobuhiko Akazawa, Song-Gyu RA, K Kimura, Y Shibagaki and Seiji Maeda :
Effect of habitual exercise on urinary liver-type fatty acid-binding protein levels in middle-aged and older adults.,
Scandinavian Journal of Medicine & Science in Sports, Vol.28, No.1, 152-160, 2017.

(要約): The purpose of this study was to examine the effect of habitual exercise on urinary liver-type fatty acid-binding protein (L-FABP), which can reflect the degree of various stresses on renal proximal tubule related to the progression of renal disease, in middle-aged and older adults. Cross-sectional and interventional approaches were used to comprehensively achieve this purpose. In the cross-sectional study, we investigated the relationship between physical activity levels and urinary L-FABP levels in 130 middle-aged and older adults. In the interventional study, subjects (n=31) were divided into two groups: exercise (n=19) and control group (n=12), whereby we examined the effects of 12-week aerobic exercise training on urinary L-FABP levels. The cross-sectional study showed that the urinary L-FABP levels were significantly lower in the higher physical activity group than in the lower physical activity group (P<.05). In the interventional study, 12-week aerobic exercise training significantly decreased urinary L-FABP levels (P<.01). Furthermore, the relative changes in urinary L-FABP levels were significantly correlated with the relative changes in physical activity levels and mean arterial pressure after intervention (r=-.374 and r=.530, respectively). Our results revealed that the urinary L-FABP levels were lower in the higher physical activity individuals, and aerobic exercise training decreased urinary L-FABP levels. These results suggest that habitual exercise appears to be associated with a decrease in the degree of several stresses on renal proximal tubule and to be beneficial for kidney health in middle-aged and older adults.
(出版サイトへのリンク): ● Publication site (DOI): 10.1111/sms.12867
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28247579; ● Search Scopus @ Elsevier (PMID): 28247579; ● Search Scopus @ Elsevier (DOI): 10.1111/sms.12867

(DOI: 10.1111/sms.12867, PubMed: 28247579) Keisei Kosaki, Atsuko Kamijo-Ikemori, Takeshi Sugaya, Koichiro Tanahashi, Hiroshi Kumagai, Yuriko Sawano, Nobuhiko Akazawa, Song-Gyu RA, Kenjiro Kimura, Yugo Shibagaki and Seiji Maeda :
Relationship between exercise capacity and urinary liver-type fatty acid-binding protein in middle-aged and older individuals.,
Clinical and Experimental Nephrology, Vol.21, No.5, 810-817, 2017.

(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s10157-017-1385-x
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28197733; ● Search Scopus @ Elsevier (PMID): 28197733; ● Search Scopus @ Elsevier (DOI): 10.1007/s10157-017-1385-x

(DOI: 10.1007/s10157-017-1385-x, PubMed: 28197733) Teruo Miyazaki, Yuho Nakamura, Kei Ebina, Takaki Mizushima, Song-Gyu RA, Keisuke Ishikura, Yasushi Matsuzaki, Hajime Ohmori and Akira Honda :
Increased N-Acetyltaurine in the Skeletal Muscle After Endurance Exercise in Rat.,
Advances in Experimental Medicine and Biology, Vol.975 Pt 1, 403-411, 2017.

(要約): Taurine is metabolized to a novel metabolite, N-acetyltaurine (NAT), through N-acetylation with acetate. Furthermore, NAT production increases when the endogenous production of acetate is elevated in some situations, such as alcohol catabolism and endurance exercise. We have previously reported that both the serum concentration and urinary excretion of NAT from humans were increased after endurance exercise, and that NAT was secreted by cultured skeletal muscle cells exposed to both acetate and taurine. The present study evaluated the hypothesis that NAT is synthesized in the skeletal muscle after endurance exercise. Normal rats were loaded to a transient treadmill running until exhaustion. Serum, skeletal muscle, and liver were collected immediately after the exercise. The NAT concentration in the plasma and in the soleus muscle from the exercised rats was significantly increased compared to that in the samples from the sedentary control rats. There was a significant positive correlation in the NAT concentration between the plasma and soleus muscle. The NAT concentration in the liver was unchanged after the endurance exercise. These results confirm that the significantly increased NAT in both the serum and urine after endurance exercise is derived from NAT synthesis in the skeletal muscle.
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/978-94-024-1079-2_33
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28849471; ● Search Scopus @ Elsevier (PMID): 28849471; ● Search Scopus @ Elsevier (DOI): 10.1007/978-94-024-1079-2_33

(DOI: 10.1007/978-94-024-1079-2_33, PubMed: 28849471) Youngju Choi, Nobuhiko Akazawa, Asako Zempo-Miyaki, Song-Gyu RA, Hitoshi Shiraki, Ryuichi Ajisaka and Seiji Maeda :
Acute Effect of High-Intensity Eccentric Exercise on Vascular Endothelial Function in Young Men.,
Journal of Strength and Conditioning Research, Vol.30, No.8, 2279-2285, 2016.

(要約): Choi, Y, Akazawa, N, Zempo-Miyaki, A, Ra, S-G, Shiraki, H, Ajisaka, R, and Maeda, S. Acute effect of high-intensity eccentric exercise on vascular endothelial function in young men. J Strength Cond Res 30(8): 2279-2285, 2016-Increased central arterial stiffness is as an independent risk factor for cardiovascular disease. Evidence regarding the effects of high-intensity resistance exercise on vascular endothelial function and central arterial stiffness is conflicting. The purpose of this study was to examine the effects of acute high-intensity eccentric exercise on vascular endothelial function and central arterial stiffness. We evaluated the acute changes in endothelium-dependent flow-mediated dilation (FMD), low-flow-mediated constriction (L-FMC), and arterial stiffness after high-intensity eccentric exercise. Seven healthy, sedentary men (age, 24 ± 1 year) performed maximal eccentric elbow flexor exercise using their nondominant arm. Before and 45 minutes after eccentric exercise, carotid arterial compliance and brachial artery FMD and L-FMC in the nonexercised arm were measured. Carotid arterial compliance was significantly decreased, and β-stiffness index significantly increased after eccentric exercise. Brachial FMD was significantly reduced after eccentric exercise, whereas there was no significant difference in brachial L-FMC before and after eccentric exercise. A positive correlation was detected between change in arterial compliance and change in FMD (r = 0.779; p 0.05), and a negative correlation was detected between change in β-stiffness index and change in FMD (r = -0.891; p < 0.01) with eccentric exercise. In this study, acute high-intensity eccentric exercise increased central arterial stiffness; this increase was accompanied by a decrease in endothelial function caused by reduced endothelium-dependent vasodilation but not by a change in endothelium-dependent vasoconstriction.
(出版サイトへのリンク): ● Publication site (DOI): 10.1519/JSC.0000000000000536
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24832967; ● Search Scopus @ Elsevier (PMID): 24832967; ● Search Scopus @ Elsevier (DOI): 10.1519/JSC.0000000000000536

(DOI: 10.1519/JSC.0000000000000536, PubMed: 24832967) Takehito Sugasawa, Naoki Mukai, K Tamura, T Tamba, S Mori, Y Miyashiro, M Yamaguchi, S Nissato, Song-Gyu RA, Yasuko Yoshida, M Hoshino, Hajime Ohmori, Yasushi Kawakami and Kazuhiro Takekoshi :
Effects of Cold Stimulation on Mitochondrial Activity and VEGF Expression in vitro.,
International Journal of Sports Medicine, Vol.37, No.10, 766-778, 2016.

(要約): We aimed to clarify the effects of cold stimulation at various temperatures on mitochondrial activity and vascular endothelial growth factor (VEGF) expression in vitro. Human fibroblast, human mesenchymal stem cell, and rat skeletal muscle myoblast cell lines were used. For each cell type, cells were divided into 4 groups and stimulated in various cold temperatures (0, 4, 17 and 25°C) 3 times for 15 min each by placement on crushed ice or floating on cold water set at each temperature. Control cells were subjected to warm water at 37°C. Factors related to mitochondrial activity, mitochondrial DNA copy numbers, and VEGF expression were analyzed 24 h after the last cold stimulation. In all cell types, significant increases of factors related to mitochondrial activity and mitochondrial DNA copy numbers were seen in the 4°C and 17°C-stimulated cells compared with control cells. In rat skeletal muscle cells stimulated at 4°C, VEGF expression significantly increased compared to the control cells. Our data suggest that cold stimulation at certain temperatures promotes mitochondrial activity, biogenesis and VEGF expression.
(出版サイトへのリンク): ● Publication site (DOI): 10.1055/s-0042-102659
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27116343; ● Search Scopus @ Elsevier (PMID): 27116343; ● Search Scopus @ Elsevier (DOI): 10.1055/s-0042-102659

(DOI: 10.1055/s-0042-102659, PubMed: 27116343) Song-Gyu RA, Youngju Choi, Nobuhiko Akazawa, Hajime Ohmori and Seiji Maeda :
Taurine supplementation attenuates delayed increase in exercise-induced arterial stiffness.,
Applied Physiology, Nutrition, and Metabolism, Vol.41, No.6, 618-623, 2016.

(要約): There is a delayed increase in arterial stiffness after eccentric exercise that is possibly mediated by the concurrent delayed increase in circulating oxidative stress. Taurine has anti-oxidant action, and taurine supplementation may be able to attenuate the increase in oxidative stress after exercise. The purpose of the present study was to investigate whether taurine supplementation attenuates the delayed increase in arterial stiffness after eccentric exercise. In the present double-blind, randomized, and placebo-controlled trial, we divided 29 young, healthy men into 2 groups. Subjects received either 2.0 g of placebo (n = 14) or taurine (n = 15) 3 times per day for 14 days prior to the exercise, on the day of exercise, and the following 3 days. The exercise consisted of 2 sets of 20 maximal-effort eccentric repetitions with the nondominant arm only. On the morning of exercise and for 4 days thereafter, we measured serum malondialdehyde (MDA) and carotid-femoral pulse wave velocity (cfPWV) as indices of oxidative stress and arterial stiffness, respectively. On the third and fourth days after exercise, both MDA and cfPWV significantly increased in the placebo group. However, these elevations were significantly attenuated in the taurine group. The increase in MDA was associated with an increase in cfPWV from before exercise to 4 days after exercise (r = 0.597, p < 0.05) in the placebo group, but not in the taurine group. Our results suggest that delayed increase in arterial stiffness after eccentric exercise was probably affected by the exercise-induced oxidative stress and was attenuated by the taurine supplementation.
(出版サイトへのリンク): ● Publication site (DOI): 10.1139/apnm-2015-0560
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27163699; ● Search Scopus @ Elsevier (PMID): 27163699; ● Search Scopus @ Elsevier (DOI): 10.1139/apnm-2015-0560

(DOI: 10.1139/apnm-2015-0560, PubMed: 27163699) Takehito SUGASAWA, Naoki MUKAI, Kyoko TAMURA, Taiko TAMBA, Shintaro MORI, Yuki MIYASHIRO, Mami YAMAGUCHI, Norihiko MORIYAMA, Sumiko NISSATO, Song-Gyu RA, Yasuko YOSHIDA, Yasushi KAWAKAMI and Kazuhiro TAKEKOSHI :
Effect of closed fracture on spot urinary thiobarbituric acid reactive substance level in old rats,
Gazzetta Medica Italiana Archivio per le Scienze Mediche, Vol.175, No.1-2, 15-22, 2016.

(出版サイトへのリンク): ● Publication site (DOI): 10.23736/S0393-3660.16.03312-X
(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-85014452052

(DOI: 10.23736/S0393-3660.16.03312-X, Elsevier: Scopus) Nobuhiko Akazawa, Song-Gyu RA, Jun Sugawara and Seiji Maeda :
Influence of aerobic exercise training on post-exercise responses of aortic pulse pressure and augmentation pressure in postmenopausal women.,
Frontiers in Physiology, Vol.6, 268, 2015.

(要約): Central arterial blood pressure (BP) is more predictive of future cardiovascular events than is brachial BP because it reflects the BP load imposed on the left ventricle with greater accuracy. However, little is known about the effects of exercise training on central hemodynamic response to acute exercise. The purpose of the present study was to determine the influence of an aerobic exercise regimen on the response of aortic BP after a single aerobic exercise in postmenopausal women. Nine healthy postmenopausal women (age: 61 ± 2 years) participated in a 12-week aerobic exercise training regimen. Before and after the training, each subjects performed a single bout of cycling at ventilatory thresholds for 30 min. We evaluated the post-exercise aortic BP response, which was estimated via the general transfer function from applanation tonometry. After the initial pre-training aerobic exercise session, aortic BP did not change significantly: however, aortic pulse pressure and augmentation pressure were significantly attenuated after the single aerobic exercise session following the 12-week training regimen. The present study demonstrated that a regular aerobic exercise training regimen induced the post-exercise reduction of aortic pulse pressure and augmentation pressure. Regular aerobic exercise training may enhance post-exercise reduction in aortic BP.
(出版サイトへのリンク): ● Publication site (DOI): 10.3389/fphys.2015.00268
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26500554; ● Search Scopus @ Elsevier (PMID): 26500554; ● Search Scopus @ Elsevier (DOI): 10.3389/fphys.2015.00268

(DOI: 10.3389/fphys.2015.00268, PubMed: 26500554) Yoko Tanabe, Seiji Maeda, Nobuhiko Akazawa, Asako Zempo-Miyaki, Youngju Choi, Song-Gyu RA, Atsushi Imaizumi, Yoshihiko Otsuka and Kazunori Nosaka :
Attenuation of indirect markers of eccentric exercise-induced muscle damage by curcumin.,
European Journal of Applied Physiology, Vol.115, No.9, 1949-1957, 2015.

(要約): It is concluded that theracurmin ingestion attenuates some aspects of muscle damage such as MVC loss and CK activity increase.
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s00421-015-3170-4
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25921600; ● Search Scopus @ Elsevier (PMID): 25921600; ● Search Scopus @ Elsevier (DOI): 10.1007/s00421-015-3170-4

(DOI: 10.1007/s00421-015-3170-4, PubMed: 25921600) 石倉恵介, 宮﨑照雄, 松坂賢, 羅成圭, 宮川俊平, 大森肇 :
骨格筋糖代謝ならびにアミノ酸代謝関連の遺伝子発現に及ぼすタウリン投与の影響,
タウリンリサーチ, Vol.1, No.1, 59-62, 2015年.

(要約): 骨格筋の糖代謝ならびにセリン・グリシン・スレオニンのアミノ酸代謝の遺伝子発現に及ぼすタウリン投与の影響を明らかにすることを目的とした．ラットへ2 週間タウリンを経口投与し，腓腹筋内側頭白色部の遺伝子発現をDNA マイクロアレイ法にて網羅的に解析を行った．その結果，タウリン投与によって，骨格筋の糖代謝ならびにセリン・グリシン・スレオニンのアミノ酸代謝には影響を及ぼさなかった．タウリン投与のエネルギー代謝への影響は骨格筋よりむしろ肝臓など他の臓器への作用が関連する可能性が示唆された．
(出版サイトへのリンク): ● Publication site (DOI): 10.32172/taurine.1.1_59
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390564227317322752; ● Search Scopus @ Elsevier (DOI): 10.32172/taurine.1.1_59

(DOI: 10.32172/taurine.1.1_59, CiNii: 1390564227317322752) Teruo Miyazaki, Keisuke Ishikura, Akira Honda, Song-Gyu RA, Shoichi Komine, Yasunori Miyamoto, Hajime Ohmori and Yasushi Matsuzaki :
Increased N-acetyltaurine in serum and urine after endurance exercise in human.,
Advances in Experimental Medicine and Biology, Vol.803, 53-62, 2015.

(出版サイトへのリンク): ● Publication site (DOI): 10.1007/978-3-319-15126-7_5
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25833487; ● Search Scopus @ Elsevier (PMID): 25833487; ● Search Scopus @ Elsevier (DOI): 10.1007/978-3-319-15126-7_5

(DOI: 10.1007/978-3-319-15126-7_5, PubMed: 25833487) Song-Gyu RA, Nobuhiko Akazawa, Youngju Choi, Tomoko Matsubara, Satoshi Oikawa, Hiroshi Kumagai, Koichiro Tanahashi, Hajime Ohmori and Seiji Maeda :
Taurine supplementation reduces eccentric exercise-induced delayed onset muscle soreness in young men.,
Advances in Experimental Medicine and Biology, Vol.803, 765-772, 2015.

(出版サイトへのリンク): ● Publication site (DOI): 10.1007/978-3-319-15126-7_61
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25833543; ● Search Scopus @ Elsevier (PMID): 25833543; ● Search Scopus @ Elsevier (DOI): 10.1007/978-3-319-15126-7_61

(DOI: 10.1007/978-3-319-15126-7_61, PubMed: 25833543) Tomoko MATSUBARA, Asako ZEMPO-MIYAKI, Nobuhiko AKAZAWA, Youngju CHOI, Song-Gyu RA, Koichiro TANAHASHI, Hiroshi KUMAGAI, Satoshi OIKAWA, Toru YOSHIKAWA and Seiji MAEDA :
Aerobic Exercise Training Improves Vascular Endothelial Function with an Increase in Circulating Klotho Levels in Postmenopausal Women,
Advances in Exercise and Sports Physiology, Vol.20, No.3, 61-66, 2014.

(要約): Circulating Klotho is expected to have vascular protective effects, including the enhancement of nitric oxide (NO) production by endothelial cells. Aerobic exercise training increases circulating Klotho levels and improves endothelial function, which decreases with aging. However, it is unclear whether aerobic exercise training-induced improvement in endothelial function is related to elevation of circulating Klotho levels. In the present study, we investigated the effect of aerobic exercise training on the correlation between plasma Klotho levels and endothelial function in postmenopausal women. First, we studied the correlation between plasma Klotho levels and flow-mediated vasodilation (FMD) as an index of endothelial function. FMD correlated positively with plasma Klotho levels, but the baseline diameter did not correlate with plasma Klotho levels. Second, we examined the effects of aerobic exercise training on plasma Klotho levels and FMD. After aerobic exercise training, plasma Klotho levels and FMD increased significantly. Furthermore, there was a positive correlation between the changes in plasma Klotho levels and those in FMD. These results suggested that an increase in circulating Klotho levels induced by aerobic exercise training may contribute to improvement of endothelial function.
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1520009409933187584

(CiNii: 1520009409933187584) Hiroshi Kumagai, Asako Miyaki, Ryota Higashino, Nobuhiko Akazawa, Youngju Choi, Song-Gyu RA, Miki Eto, Kiyoji Tanaka, Ryuichi Ajisaka and Seiji Maeda :
Lifestyle modification-induced increase in serum testosterone and SHBG decreases arterial stiffness in overweight and obese men,
Artery Research, Vol.8, No.3, 80-87, 2014.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.artres.2014.04.003
(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-84905728604

(DOI: 10.1016/j.artres.2014.04.003, Elsevier: Scopus) Song-Gyu RA, Seiji Maeda, Ryota Higashino, Tomoko Imai and Shumpei Miyakawa :
Metabolomics of salivary fatigue markers in soccer players after consecutive games.,
Applied Physiology, Nutrition, and Metabolism, Vol.39, No.10, 1120-1126, 2014.

(要約): Strenuous and consecutive exercise leads to fatigue symptoms in athletes. Metabolomics is a comprehensive method to assess metabolites that involves the measurements of the overall metabolic signature of biological samples. Using metabolomic analysis, we investigated the identification of salivary fatigue markers in soccer players after 3 consecutive days of a game program. One hundred twenty-two male soccer players participated in 3 consecutive days of a game program. To detect fatigued athletes, we measured indices of traditional fatigue symptoms, i.e., heart rate, body mass and mood, before and after the program. We detected 37 fatigued players throughout the program. Before and after the program, the saliva in these players was analyzed using capillary electrophoresis and time-of-flight mass spectrometry (CE-TOFMS) and a multivariate statistical technique, principal component analysis, was used to process the data. CE-TOFMS was used to identify 144 metabolites in the saliva of fatigued players. A significant metabolomic difference was observed before and after 3 consecutive days of a soccer game program. Interestingly, metabolites were all increased after the program (P < 0.001). The identified metabolites, including 3-methylhistidine, glucose 1- and 6-phosphate, taurine, and some amino acids, were involved in skeletal muscle catabolism, glucose metabolism, lipid metabolism, amino acid metabolism, and energy metabolism. Our work demonstrated some salivary metabolites were significantly increased in the fatigued players after consecutive days of short soccer matches. We propose that the detected salivary metabolites may be new fatigue markers in athletes.
(出版サイトへのリンク): ● Publication site (DOI): 10.1139/apnm-2013-0546
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24988119; ● Search Scopus @ Elsevier (PMID): 24988119; ● Search Scopus @ Elsevier (DOI): 10.1139/apnm-2013-0546

(DOI: 10.1139/apnm-2013-0546, PubMed: 24988119) Koichiro Tanahashi, Nobuhiko Akazawa, Asako Miyaki, Youngju Choi, Song-Gyu RA, Tomoko Matsubara, Hiroshi Kumagai, Satoshi Oikawa, Takashi Miyauchi and Seiji Maeda :
Plasma ADMA concentrations associate with aerobic fitness in postmenopausal women.,
Life Sciences, Vol.108, No.1, 30-33, 2014.

(要約): We found that plasma ADMA concentrations were associated with aerobic fitness in postmenopausal women. The results of this study suggest that habitual aerobic exercise may decrease plasma ADMA concentrations.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.lfs.2014.05.003
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24825610; ● Search Scopus @ Elsevier (PMID): 24825610; ● Search Scopus @ Elsevier (DOI): 10.1016/j.lfs.2014.05.003

(DOI: 10.1016/j.lfs.2014.05.003, PubMed: 24825610) Koichiro Tanahashi, Nobuhiko Akazawa, Asako Miyaki, Youngju Choi, Song-Gyu RA, Tomoko Matsubara, Hiroshi Kumagai, Satoshi Oikawa and Seiji Maeda :
Aerobic exercise training decreases plasma asymmetric dimethylarginine concentrations with increase in arterial compliance in postmenopausal women.,
American Journal of Hypertension, Vol.27, No.3, 415-421, 2014.

(要約): We demonstrated that aerobic exercise training significantly decreased plasma ADMA concentrations with increase in carotid arterial compliance in postmenopausal women. These results suggest that reduction in ADMA may play an important role in the aerobic exercise training-induced increase in arterial compliance.
(出版サイトへのリンク): ● Publication site (DOI): 10.1093/ajh/hpt217
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24280041; ● Search Scopus @ Elsevier (PMID): 24280041; ● Search Scopus @ Elsevier (DOI): 10.1093/ajh/hpt217

(DOI: 10.1093/ajh/hpt217, PubMed: 24280041) 羅成圭, 崔英珠, 赤澤暢彦 :
若年男性における血漿タウリン濃度と血管内皮機能に関する横断研究,
健康支援, Vol.16, No.1, 15-22, 2014年.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1520009409751393152

(CiNii: 1520009409751393152) 羅成圭, 前田清司, 今井智子, 宮川俊平 :
男子大学サッカー選手における試合合宿前後の唾液中タウリン濃度の変動,
体力科学, Vol.63, No.4, 409-414, 2014年.

(要約): Strenuous and consecutive exercise results in fatigue symptoms accompanied decrease in salivary secretory immunoglobulin A (sIgA) in athletes. On the other hand, it has been reported that plasma taurine concentration was increased after the high intensity exercise. However, change in salivary taurine concentration after strenuous and consecutive exercise is unknown. The purpose of this study was to investigate the relationship between fatigue symptoms and changes in salivary taurine concentration in collegiate male soccer players. Thirty seven collegiate male soccer players participated in three consecutive days of match program. To detect of fatigued players, we measured awakening heart rate and body weight. As the results of these two measurements, we divided subjects to two groups (non-fatigue group, n=15; fatigue group, n=22). We also measured salivary sIgA and taurine concentrations before and after program. Before the program, there were no significant differences in any parameters between two groups. Salivary flow rate and sIgA secretion rate were significantly decreased after the program in the fatigue group. Furthermore, salivary taurine concentration was significantly increased after the program in the fatigue group. In the non-fatigue group, there were no significant differences in any parameters during program. Our results indicated that salivary taurine concentration increased after consecutive high-intense exercise in the collegiate male soccer players.
(出版サイトへのリンク): ● Publication site (DOI): 10.7600/jspfsm.63.409
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390282679897258624; ● Summary page in Scopus @ Elsevier: 2-s2.0-84904979431

(DOI: 10.7600/jspfsm.63.409, CiNii: 1390282679897258624, Elsevier: Scopus) Tomoko Matsubara, Asako Miyaki, Nobuhiko Akazawa, Youngju Choi, Song-Gyu RA, Koichiro Tanahashi, Hiroshi Kumagai, Satoshi Oikawa and Seiji Maeda :
Aerobic exercise training increases plasma Klotho levels and reduces arterial stiffness in postmenopausal women.,
American Journal of Physiology, Heart and Circulatory Physiology, Vol.306, No.3, H348-H355, 2013.

(要約): The Klotho gene is a suppressor of the aging phenomena, and the secretion as well as the circulation of Klotho proteins decrease with aging. Although habitual exercise has antiaging effects (e.g., a decrease in arterial stiffness), the relationship between Klotho and habitual exercise remains unclear. In the present study, we investigated the effect of habitual exercise on Klotho, with a particular focus on arterial stiffness. First, we examined the correlation between plasma Klotho concentration and arterial stiffness (carotid artery compliance and β-stiffness index) or aerobic exercise capacity [oxygen uptake at ventilatory threshold (VT)] in 69 healthy, postmenopausal women (50-76 years old) by conducting a cross-sectional study. Second, we tested the effects of aerobic exercise training on plasma Klotho concentrations and arterial stiffness. A total of 19 healthy, postmenopausal women (50-76 years old) were divided into two groups: control group and exercise group. The exercise group completed 12 wk of moderate aerobic exercise training. In the cross-sectional study, plasma Klotho concentrations positively correlated with carotid artery compliance and VT and negatively correlated with the β-stiffness index. In the interventional study, aerobic exercise training increased plasma Klotho concentrations and carotid artery compliance and decreased the β-stiffness index. Moreover, the changes in plasma Klotho concentration and arterial stiffness were found to be correlated. These results suggest a possible role for secreted Klotho in the exercise-induced modulation of arterial stiffness.
(出版サイトへのリンク): ● Publication site (DOI): 10.1152/ajpheart.00429.2013
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24322608; ● Search Scopus @ Elsevier (PMID): 24322608; ● Search Scopus @ Elsevier (DOI): 10.1152/ajpheart.00429.2013

(DOI: 10.1152/ajpheart.00429.2013, PubMed: 24322608) Ryota Higashino, Asako Miyaki, Hiroshi Kumagai, Youngju Choi, Nobuhiko Akazawa, Song-Gyu RA, Yoko Tanabe, Miki Eto, Rina So, Kiyoji Tanaka, Ryuichi Ajisaka and Seiji Maeda :
Effects of lifestyle modification on central blood pressure in overweight and obese men.,
Blood Pressure Monitoring, Vol.18, No.6, 311-315, 2013.

(要約): This study showed for the first time that lifestyle modification-induced weight loss decreases central systolic blood pressure in overweight and obese men. The decrease in central systolic blood pressure was associated with the reduction in arterial stiffness. These results suggest that lifestyle modification-induced reduction in arterial stiffness may contribute toward the decreased central systolic blood pressure in overweight and obese men.
(出版サイトへのリンク): ● Publication site (DOI): 10.1097/MBP.0000000000000006
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24192844; ● Search Scopus @ Elsevier (PMID): 24192844; ● Search Scopus @ Elsevier (DOI): 10.1097/MBP.0000000000000006

(DOI: 10.1097/MBP.0000000000000006, PubMed: 24192844) Song-Gyu RA, Teruo Miyazaki, Keisuke Ishikura, Hisashi Nagayama, Shoichi Komine, Yoshio Nakata, Seiji Maeda, Yasushi Matsuzaki and Hajime Ohmori :
Combined effect of branched-chain amino acids and taurine supplementation on delayed onset muscle soreness and muscle damage in high-intensity eccentric exercise.,
Journal of the International Society of Sports Nutrition, Vol.10, No.1, 51, 2013.

(要約): A combination of 3.2 g BCAA and 2.0 g taurine, three times a day, for two weeks prior to and three days after exercise may be a useful nutritional strategy for attenuating exercise-induced DOMS and muscle damage.
(出版サイトへのリンク): ● Publication site (DOI): 10.1186/1550-2783-10-51
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24195702; ● Search Scopus @ Elsevier (PMID): 24195702; ● Search Scopus @ Elsevier (DOI): 10.1186/1550-2783-10-51

(DOI: 10.1186/1550-2783-10-51, PubMed: 24195702) Keisuke ISHIKURA, Teruo MIYAZAKI, Song-Gyu RA and Hajime OHMORI :
The ameliorating effect of branched-chain amino acid ingestion on different types of muscle soreness after swimming and full-marathon running,
Advances in Exercise and Sports Physiology, Vol.20, No.1, 9-17, 2013.

(要約): The effectiveness of branched-chain amino acids (BCAA) ingestion on delayed onset muscle soreness (DOMS) has been established in experimental exercise involving eccentric contraction (ECC). This placebo-controlled, randomized, double-blind study evaluated the effect of BCAA ingestion on two types of muscle soreness after swimming (which generally involves little ECC) and immediate onset muscle soreness (IOMS) after a full-marathon and on systemic fatigue. Subjects were 32 swimmers competing in a university swim meet and 22 non-professional runners participating in a full-marathon race. They received either 3.2g of BCAA or placebo three times a day, from the day before to two days after their events. Systemic fatigue and soreness in muscle regions (seven regions in swimmers, six in runners) were evaluated using a numeric rating scale before, immediately after, and one and two days after the events. In the swimmers, muscle soreness in the upper body (neck, upper arm, back, and low back), buttock, and thigh and systemic fatigue were significantly decreased after two days in the BCAA group. In the runners, IOMS occurred in all examined regions immediately after the marathon, and BCAA ingestion significantly decreased both muscle soreness in the anterior thigh, anterior lower leg, and buttock and systemic fatigue within two days. This study showed the effectiveness of BCAA ingestion on improving systemic fatigue, muscle soreness after swimming, and IOMS after a full-marathon. On the basis of these results, it is proposed that BCAA supplements can be administered to ameliorate muscle soreness and fatigue induced by various types of exercise.
(キーワード): immediate onset muscle soreness / branched-chain amino acids / delayed onset muscle soreness / marathon / swimming
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1520853834862638464

(CiNii: 1520853834862638464) Song-Gyu RA, Teruo Miyazaki, Keisuke Ishikura, Hisashi Nagayama, Takafumi Suzuki, Seiji Maeda, Masaharu Ito, Yasushi Matsuzaki and Hajime Ohmori :
Additional effects of taurine on the benefits of BCAA intake for the delayed-onset muscle soreness and muscle damage induced by high-intensity eccentric exercise.,
Advances in Experimental Medicine and Biology, Vol.776, 179-187, 2013.

(要約): Taurine (TAU) has a lot of the biological, physiological, and pharmocological functions including anti-inflammatory and anti-oxidative stress. Although previous studies have appreciated the effectiveness of branched-chain amino acids (BCAA) on the delayed-onset muscle soreness (DOMS), consistent finding has not still convinced. The aim of this study was to examine the additional effect of TAU with BCAA on the DOMS and muscle damages after eccentric exercise. Thirty-six untrained male volunteers were equally divided into four groups, and ingested a combination with 2.0 g TAU (or placebo) and 3.2 g BCAA (or placebo), thrice a day, 2 weeks prior to and 4 days after elbow flexion eccentric exercise. Following the period after eccentric exercise, the physiological and blood biochemical markers for DOMS and muscle damage showed improvement in the combination of TAU and BCAA supplementation rather than in the single or placebo supplementations. In conclusion, additional supplement of TAU with BCAA would be a useful way to attenuate DOMS and muscle damages induced by high-intensity exercise.
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/978-1-4614-6093-0_18
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23392882; ● Search Scopus @ Elsevier (PMID): 23392882; ● Search Scopus @ Elsevier (DOI): 10.1007/978-1-4614-6093-0_18

(DOI: 10.1007/978-1-4614-6093-0_18, PubMed: 23392882) Keisuke Ishikura, Teruo Miyazaki, Song-Gyu RA, Shoji Endo, Yusuke Nakamura, Takashi Matsuzaka, Shumpei Miyakawa and Hajime Ohmori :
Effect of taurine supplementation on the alterations in amino Acid content in skeletal muscle with exercise in rat.,
Journal of Sports Science & Medicine, Vol.10, No.2, 306-314, 2011.

(要約): Taurine included abundantly in skeletal muscle, particularly in the slow-twitch fibers, enhances exercise performance. However, the exact mechanisms for this effect have been unclear. The present study investigated the influence of taurine supplementation on amino acids profile in skeletal muscles as one of mechanisms in the enhancement of exercise performance induced by taurine. In the rats that received taurine solution, amino acids concentrations were comprehensively quantified in two portions with different fiber compositions in the fast-twitch fiber dominant (FFD) gastrocnemius muscle after 2 weeks, and in the gastrocnemius and additional other FFD muscles, liver, and plasma with exhausted exercise after 3 weeks. In the FFD muscles after 2 weeks, a common phenomenon that decreased concentrations of threonine (-16%), serine (-15~-16%), and glycine (-6~-16%) were observed, and they are categorized in the pyruvate precursors for hepatic gluconeogenesis rather than biosynthesis, polar, and side-chain structures. The decreases in the three amino acids were significantly emphasized after an additional week of taurine supplementation in the FFD muscles (p values in three amino acids in these tissues were less than 0.001-0.05), but not in the liver and plasma, accompanied with significantly increase of running time to exhaustion (p <0.05). In contrast, the three amino acids (threonine and serine; p < 0.05, glycine; p < 0.01) and alanine (p < 0.01) in the liver were significantly decreased and increased, respectively, following the exhaustive exercise. In conclusion, the taurine-induced reductions of these amino acids in skeletal muscle might be one of the mechanisms which underpin the enhancement of exercise performance by taurine. Key pointsTaurine ingestion significantly decreased certain amino acids in skeletal muscles accompanied with enhanced exercise performance.The decreased amino acids in common were threonine, serine, and glycine, but not alanine; pyruvate precursor for gluconeogenesis.The alteration of three amino acids in muscles was maintained after exhausted exercise.The muscular alterations of them might be one of taurine-induced roles on exercise performance.
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24149876; ● Summary page in Scopus @ Elsevier: 2-s2.0-79958080982

(PubMed: 24149876, Elsevier: Scopus)

MISC

羅成圭, 志内哲也 :
タウリン摂取がマウス骨格筋の糖・脂質代謝関連因子へ及ぼす影響,
タウリンリサーチ, Vol.9, No.1, 10-12, 2023年. 羅成圭 :
タウリンと骨格筋の血糖取り込み (特集タウリン研究アップデート2020),
タウリンリサーチ, Vol.6, No.1, 43-46, 2020年.

(要約): 日本において糖尿病は国民病と言えるほど罹患者の多い疾患であるが，タウリンには糖尿病による高血糖状態を改善する効果がある．骨格筋はインスリンや運動(筋収縮)の作用で血糖を取り込み，血糖値を低下させる重要な器官である．本稿では「膵臓からのインスリン分泌」と「骨格筋における血糖取り込み」にタウリンが及ぼす影響についてまとめた．タウリンは，膵臓からのインスリン分泌や，インスリンシグナル関連因子，そして糖輸送体GLUT4 の発現量を高めるようだ．しかし，タウリンがインスリン標的器官である骨格筋における血糖取り込みに及ぼす影響ついては十分に研究されておらず，タウリンが骨格筋の血糖取り込みを高める機序については，これから更なる研究が必要である．
(キーワード): インスリン / 血糖 / AMPK / GLUT4
(徳島大学機関リポジトリ): ● Metadata: 116143
(出版サイトへのリンク): ● Publication site (DOI): 10.32172/taurine.6.1_43
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390570930252137216; ● Search Scopus @ Elsevier (DOI): 10.32172/taurine.6.1_43

(徳島大学機関リポジトリ: 116143, DOI: 10.32172/taurine.6.1_43, CiNii: 1390570930252137216) 羅成圭, 中原未央, 川中健太郎 :
経口タウリン摂取がヒトの筋力に及ぼす影響 (特集第5回国際タウリン研究会日本部会プロシーディングス),
タウリンリサーチ, Vol.5, No.1, 16-18, 2019年.

(出版サイトへのリンク): ● Publication site (DOI): 10.32172/taurine.5.1_16
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390848647551159040; ● Search Scopus @ Elsevier (DOI): 10.32172/taurine.5.1_16

(DOI: 10.32172/taurine.5.1_16, CiNii: 1390848647551159040) 羅成圭 :
スポーツ科学分野におけるタウリン投与の効果に関する,
タウリンリサーチ, Vol.4, No.1, 22-24, 2018年.

(要約): 本 Short Review では，タウリンの「投与期間」や「投与による組織中タウリン濃度の変化」の 2点に着目し，スポーツ科学分野におけるタウリン投与が運動パフォーマンスに及ぼす効果についてまとめた．本レビューでは，一過性のタウリン投与は血中タウリン濃度を増加させるものの運動パフォーマンスを向上させることは難しいということ，また慢性投与によって骨格筋のタウリン濃度を高めることで運動パフォーマンスが向上する可能性が高いということが示された．「タウリン投与」に関する研究は現象論レベルの報告が多く，これから「なぜ」「どのように」タウリン投与が運動パフォーマンスを向上させるのか更なる研究が望まれる．
(出版サイトへのリンク): ● Publication site (DOI): 10.32172/taurine.4.1_22
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390282752368524288; ● Search Scopus @ Elsevier (DOI): 10.32172/taurine.4.1_22

(DOI: 10.32172/taurine.4.1_22, CiNii: 1390282752368524288) 羅成圭, 前田清司, 川中健太郎, 今井智子, 宮川俊平 :
運動誘発性疲労マーカーとしての唾液中タウリンの可能性,
タウリンリサーチ, Vol.3, No.1, 6-8, 2017年.

(要約): 一過性に持久性運動をおこなうことによって，血液中のタウリン濃度が増加するということが報告されている 1,2．そこで我々は，運動誘発性疲労時にも体液中のタウリン濃度が増加している可能性があると考え，唾液中のタウリン濃度の変化が運動誘発性疲労のマーカーとなる可能性を検証した．我々はまず，疲労したアスリートの唾液をメタボロミクスにて網羅的に解析し，いくつかの代謝産物とともに唾液中タウリンが増加していることを見出した．また，既存の運動誘発性疲労マーカーとして知られている唾液中分泌型免疫グロブリン A(sIgA)の変化と比較検討したところ，唾液中sIgAが低下するときに唾液中タウリン濃度が有意に増加することを確認した．これらの結果は，唾液中タウリンが新規運動誘発性疲労マーカーとなる可能性を示すものであると考えられる．
(出版サイトへのリンク): ● Publication site (DOI): 10.32172/taurine.3.1_6
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390282752368392064; ● Search Scopus @ Elsevier (DOI): 10.32172/taurine.3.1_6

(DOI: 10.32172/taurine.3.1_6, CiNii: 1390282752368392064) 大森肇, 中村優歩, 宮﨑照雄, 大野貴弘, 羅成圭, 海老名慧, 菅澤威仁, 竹越一博, 宮川俊平, 本多彰 :
高強度持久性運動による骨格筋N-アセチルタウリンの増加,
タウリンリサーチ, Vol.2, No.1, 43-44, 2016年.

(出版サイトへのリンク): ● Publication site (DOI): 10.32172/taurine.2.1_43
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.32172/taurine.2.1_43

(DOI: 10.32172/taurine.2.1_43) 羅成圭, 崔英珠, 赤澤暢彦, 大森肇, 前田清司 :
タウリンと血管内皮機能,
タウリンリサーチ, Vol.2, No.1, 40-42, 2016年.

(要約): 本稿では，健常者における経口タウリン摂取が血管内皮機能に及ぼす効果を，安静時および運動時に分けて概説する．我々はまず，2週間の経口タウリン摂取(6 g/day)は，健常者の血管内皮機能を僅かながら，有意に向上させることが初めて見出した．次に，運動誘発性血管内皮機能の低下に対するタウリン摂取の効果を検証したものの，2週間のタウリン摂取(6 g/day)では高強度レジスタンス運動による血管内皮機能の低下を抑制できないことが明らかになった．本稿で示すこれらの結果は，少なくとも安静時においては，健常者においてもタウリン製剤，もしくはタウリンを多く含む魚介類や海藻類の摂取は血管内皮機能を良好に保つために有効であることを示していると考える．
(出版サイトへのリンク): ● Publication site (DOI): 10.32172/taurine.2.1_40
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390001277391773952; ● Search Scopus @ Elsevier (DOI): 10.32172/taurine.2.1_40

(DOI: 10.32172/taurine.2.1_40, CiNii: 1390001277391773952) 海老名慧, 征矢英昭, 大森肇, 小峰昇一, 大野貴弘, 時野谷勝幸, 石倉惠介, 松井崇, 羅成圭, 宮﨑照雄, 宮川俊平 :
長時間運動時の血糖低下をタウリン投与が抑制する機序 ∼遊離アミノ酸を基質とした糖新生からの検討∼,
タウリンリサーチ, Vol.1, No.1, 53-55, 2015年.

(要約): タウリン投与が長時間運動時の血糖低下を抑制する機序として肝糖新生に着目し，遊離アミノ酸(FAA)の動態を検討した．8 週齢のF344 雄ラットをタウリン投与群(Tau)と非投与群(Con)に分け，さらに両群を運動前群，120 分運動群に分けた．Tau群では走行中の血糖低下が抑制された．タウリン投与は肝のG6Pase 活性を上げ，Thr，Ser，Gly を下げた．運動後，Con 群の筋Thr，Ser が上昇し，Tau 群では不変だった．逆に肝ではTau 群のThr，Ser が上昇し，Con 群では不変だった．Con 群では運動中の血糖低下に抗うために糖新生が行われたが，Tau 群では運動前から糖新生が惹起され，運動中の血糖低下を抑制した可能性がある．
(出版サイトへのリンク): ● Publication site (DOI): 10.32172/taurine.1.1_53
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390564227317132288; ● Search Scopus @ Elsevier (DOI): 10.32172/taurine.1.1_53

(DOI: 10.32172/taurine.1.1_53, CiNii: 1390564227317132288) 羅成圭, 赤澤暢彦, 崔英珠, 竹越一博, 大森肇, 前田清司 :
レジスタンス運動時のタウリン摂取の有効性,
タウリンリサーチ, Vol.1, No.1, 36-38, 2015年.

(出版サイトへのリンク): ● Publication site (DOI): 10.32172/taurine.1.1_36
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390001277363900032; ● Search Scopus @ Elsevier (DOI): 10.32172/taurine.1.1_36

(DOI: 10.32172/taurine.1.1_36, CiNii: 1390001277363900032) 大森肇, 征矢英昭, 小峰昇一, 三好貴士, 松井崇, 石倉恵介, 羅成圭, 宮﨑照雄, 正田純一, 宮川俊平 :
長時間運動の持続時間と血糖レベルの関係に及ぼすタウリン投与の影響,
タウリンリサーチ, Vol.1, No.1, 56-58, 2015年.

(要約): 頸静脈カニュレーションを用いて長時間走行中の経時的採血を可能にし，血糖の推移に及ぼすタウリン投与の影響を詳細に検討した．ラットに3%タウリン水溶液を3 週間投与し，3 時間絶食後にトレッドミル走(21.7m/min)を負荷した．疲労困憊時間は非投与群よりタウリン投与群で延長した．中盤以降の大きな血糖低下がタウリン投与群で抑制され，80分から160 分にかけて両群間に有意差を認めた．非投与群の走行序盤では血糖と疲労困憊時間に負の相関または傾向が見られ，走行中盤から正の相関へと転じた．タウリン投与群ではこの局面変化が遅く現れた．タウリンの事前投与が長時間運動の中盤以降の血糖低下を抑制し，それが疲労困憊時間に強く影響することを初めて明らかにした．
(出版サイトへのリンク): ● Publication site (DOI): 10.32172/taurine.1.1_56
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390845702293844352; ● Search Scopus @ Elsevier (DOI): 10.32172/taurine.1.1_56

(DOI: 10.32172/taurine.1.1_56, CiNii: 1390845702293844352)

総説・解説

Song-Gyu RA :
Effect of taurine on the regulation of glucose uptake in skeletal muscle,
Advances in Experimental Medicine and Biology, Vol.1370, 305-309, Jul. 2022.

(要約): Diabetes is so common in Japan as to be called a national disease. Taurine, a free amino acid found abundantly in mammalian tissues that is also a key ingredient of many "energy drinks," has been shown to be effective in improving the hyperglycemic state caused by diabetes. Taurine administration is associated with increased insulin secretion from the pancreas, higher levels of insulin signaling-related factors, and higher expression of the glucose transporter, GLUT4. Skeletal muscle is the main target organ of insulin: Via cell surface GLUT4 molecules, myocytes take up blood glucose, enabling skeletal muscle contraction. The enhancing effect of taurine on blood glucose uptake in skeletal muscle has not been fully studied, and little is known about its mechanism. This review article summarizes what is known about the effects of taurine on insulin secretion from the pancreas and especially blood glucose uptake in skeletal muscle.
(キーワード): Animals / Biological Transport / Blood Glucose / Glucose / Insulin / Mammals / Muscle Contraction / Muscle Fibers, Skeletal / Muscle, Skeletal / Taurine
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/978-3-030-93337-1_29
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35882805; ● Search Scopus @ Elsevier (PMID): 35882805; ● Search Scopus @ Elsevier (DOI): 10.1007/978-3-030-93337-1_29

(DOI: 10.1007/978-3-030-93337-1_29, PubMed: 35882805) 羅成圭, 檜垣靖樹, 川中健太郎 :
骨格筋の糖代謝における低強度身体活動の重要性,
Research -Central Research Institute NEWS & REPORT-, Vol.23, No.4, 32-34, 2018年12月. 羅成圭 :
タウリンとBCAAの併用摂取による筋肉痛および筋損傷の抑制,
タウリンリサーチ, Vol.1, 65, 2015年. Song-Gyu RA, Keisuke Ishikura and Hajime OHMORI :
Exercise-induced changes in amino acid levels in skeletal muscle and plasma,
The Journal of Physical Fitness and Sports Medicine, Vol.2, No.3, 301-310, Aug. 2013.

(要約): During exercise, amino acid oxidation and protein breakdown are enhanced while protein synthesis is suppressed, even though protein does not constitute a quantitatively important energy source. In response to exercise-induced stimulation, various changes in free amino acids occur in skeletal muscle to meet physiological demands. Plasma amino acids are also under the influence of various types of stress, including exercise stress. For example, acute exercise increases alanine and glutamine levels, but decreases glutamate levels in skeletal muscle. At the same time, it increases tryptophan and taurine levels, but decreases glutamine levels in plasma. Prolonged exercise decreases glutamine and glutamate levels, while increasing tyrosine and phenylalanine levels in skeletal muscle. Furthermore, when prolonged exercise-induced changes in amino acid levels are compared between trained and untrained individuals, glutamate and taurine levels in skeletal muscle and phenylalanine, leucine, isoleucine, and tyrosine levels in plasma are higher in trained individuals. This review provides an overview of changes in amino acid levels in skeletal muscle and plasma, with a focus on changes induced by exercise.
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390001205416731776

(CiNii: 1390001205416731776)

講演・発表

Song-Gyu RA and Hajime Miura :
Effects of lower extremity electrical stimulation on postprandial blood glucose and arterial stiffness,
International Conference on Adaptations & Nutrition in Sports 2023, Jul. 2023. Song-Gyu RA, Nakagawa Hironari, Tomiga Yuki, Iizawa Hiroki, Nakashima Shihoko, Higaki Yasuki and Kawanaka Kentaro :
Effects of dietary vitamin D deficiency on markers of skeletal muscle mitochondrial biogenesis, dynamics, and quality control,
22nd IUNS-ICN International Congress of Nutrition in Tokyo, Japan, Dec. 2022. Song-Gyu RA :
Muscle contraction regulates skeletal muscle TXNIP expression related to local glucose uptake,
2021 International Conference of the Korean Society of Exercise Physiology, Korea-Seoul, Nov. 2021. Honda Hiroki, Song-Gyu RA, Iizawa Hiroki, Nakashima Shihoko, Tomiga Yuki, Higaki Yasuki, Kido Kohei and Kawanaka Kentaro :
Passive stretch improves insulin-stimulated glucose transport together with downregulation of TXNIP in rat immobilized soleus muscle,
Integrative Physiology of Exercise 2020, Nov. 2020. Honda Hiroki, Song-Gyu RA, Iizawa Hiroki, Nakashima Shihoko, Tomiga Yuki, Higaki Yasuki and Kawanaka Kentaro :
Passive stretch improves insulin-stimulated glucose transport together with downregulation of TXNIP in rat soleus muscle,
American College of Sports Medicines Annual Meeting 2020, May 2020. Song-Gyu RA, Hiroki Iizawa, Hiroki Honda, Emi Kawamoto, Yuki Tomiga, Yasuki Higaki and Kentaro Kawanaka :
An acute bout of exercise downregulates Thioredoxin-interacting protein (TXNIP) expression in rat skeletal muscle,
24th annual congress of the European College of Sport Science, Prague-Czech, Jul. 2019. Hiroki Honda, Song-Gyu RA, Hiroki Iizawa, Yuki Tomiga, Yasuki Higaki and Kentaro Kawanaka :
Prolonged stretch does not improve insulin-stimulated glucose transport in insulin-resistant rat soleus muscle,
24th annual congress of the European College of Sport Science, Prague-Czech, Jul. 2019. Song-Gyu RA, Youngju Choi, Nobuhiko Akazawa, Kentaro Kawanaka, Hajime Ohmori and Seiji Maeda :
Effects of taurine supplementation on vascular endothelial function at rest and after resistance exercise,
20th International Taurine Meeting, Shenyang and Dalian-China, May 2018. Kaname Tagawa, Song-Gyu RA, Hiroshi Kumagai, Y Sawano, K Yamamoto, Toru Yoshikawa, Yasuko Yoshida, Kazuhiro Takekoshi, S Sakai, Takashi Miyauchi and Seiji Maeda :
Effects of resistance training on central arterial compliance and plasma endothelin-1 levels in young men,
The Fifteenth International Conference of Endothelin, Prague-Czech, Oct. 2017. Y Tochigi, A Sawai, Nobuhiko Akazawa, Koichiro Tanahashi, Song-Gyu RA, Noboru Mesaki and Seiji Maeda :
Effect of estradiol/progesterone ratio on cognitive function at rest and during exercise in healthy young women,
22th annual congress of the European College of Sport Science, Ruhr-Germany, Jul. 2017. Teruo Miyazaki, Song-Gyu RA, Keisuke Ishikura, Hajime Ohmori, T Ikegami, Yasushi Matsuzaki and Akira Honda :
Comparison of the influence of pre-exercise BCAA supplementation on serum HMB level between endurance and resistance exercises,
Experimental Biology 2017, Chicago, Apr. 2017. Teruo Miyazaki, Yuho Nakamura, Kei Ebina, Song-Gyu RA, Keisuke Ishikura, Hajime Ohmori, T Ikegami, Yasushi Matsuzaki and Akira Honda :
Increased N-acetyltaurine in the skeletal muscle after endurance exercise,
Experimental Biology 2017, Chicago, Apr. 2017. 赤澤暢彦, 熊谷仁, 棚橋嵩一郎, 小崎恵生, 濱崎愛, 吉川徹, 妙圓園香苗, 羅成圭, 田川要, 松原朋子, 崔英珠, 前田清司 :
中高齢者における有酸素性運動能力が脳血流拍動性に及ぼす影響,
第5回NSCA国際カンファレンス, 幕張メッセ-千葉, 2017年1月. Kaname Tagawa, Song-Gyu RA, Y Sawano, K Yamamoto, Toru Yoshikawa and Seiji Maeda :
Body height affects arterial stiffness following acute resistance exercise,
21th annual Congress of the European College of Sport Science, Wien, Jul. 2016. Teruo Miyazaki, Yuho Nakamura, Kei Ebina, T Mizushima, Song-Gyu RA, Keisuke Ishikura, Yasushi Matsuzaki, Hajime Ohmori and Akira Honda :
The role of N-acetyltaurine on the normalization of energy metabolism balance in the skeletal muscle after endurance exercise,
20th International Taurine Meeting, Seoul-Korea, May 2016. Teruo Miyazaki, Keisuke Ishikura, Akira Honda, Song-Gyu RA, Hajime Ohmori and Yasushi Matsuzaki :
Serum concentrations of 3-hydroxyisobytyrate and 3-hydroxy-methylbutyrate as skeletal muscular BCAA metabolites in endurance exercise,
14th International Congress on Amino Acids, Peptides and proteins, Wien, Aug. 2015. Song-Gyu RA, Kaname Tagawa, Youngju Choi and Seiji Maeda :
Hemodynamic response to unilateral eccentric exercise with and without lactotripeptides ingestion in healthy young men.,
Cell symposia: Exercise Metabolism, Amsterdam, Jul. 2015. Kaname Tagawa, Song-Gyu RA, Youngju Choi and Seiji Maeda :
Lactotripeptides supplementation affects brachial arterial diameter and maximal isometric force following high-intensity eccentric exercise,
20th annual Congress of the European College of Sport Science, Malmo-Sweden, Jun. 2015. Keisuke Ishikura, Syoichi Komine, Song-Gyu RA, Teruo Miyazaki, Syumpei Miyakawa and Hajime Ohmori :
Ameliorating Effect of Branched-Chain Amino Acids Supplementation on Marathon-induced Muscle Damage, Inflammation and Muscle Soreness,
20th annual Congress of the European College of Sport Science, Malmo-Sweden, Jun. 2015. Song-Gyu RA, Youngju Choi, Nobuhiko Akazawa, Hajime Ohmori and Seiji Maeda :
Taurine supplementation attenuates increase in arterial stiffness following high intense eccentric exercise,
19th annual Congress of the European College of Sport Science, Amsterdam, Jul. 2014. N Akazawa, Song-Gyu RA, T Matsubara, Y Choi, K Tanahashi, A Zempo-Miyaki, H Kumagai, S Oikawa, J Sugawara and S Maeda :
Aerobic exercise training decreases aortic pulse pressure and augmentation pressure after acute aerobic exercise in middle-aged and older women,
The Pulse of Asia, Athens, Jun. 2014. Teruo Miyazaki, Keisuke Ishikura, Akira Honda, Song-Gyu RA, Syoichi Komine, Hajime Ohmori and Yasushi Matsuzaki :
Increased N-acetyltaurine in serum and urine after endurance exercise in human,
19th International Taurine Meeting, Krakow-Poland, May 2014. Song-Gyu RA, Nobuhiko Akazawa, Youngju Choi, Tomoko Matsubara, Satoshi Oikawa, Hiroshi Kumagai, Koichiro Tanahashi, Hajime Ohmori and Seiji Maeda :
Taurine supplementation decreases delayed onset muscle soreness but not muscle damage after eccentric exercise,
19th International Taurine Meeting, Krakow-Poland, May 2014. Syoichi Komine, Takashi Miyoshi, Takashi Matsui, Keisuke Ishikura, Song-Gyu RA, Teruo Miyazaki, Junichi Shoda, Hideaki Soya and Hajime Ohmori :
Taurine supplementation suppresses hypoglycemia and increases endurance running time in rats,
19th International Taurine Meeting, Krakow-Poland, May 2014. Hajime Ohmori, Takashi Miyoshi, Syoichi Komine, Keisuke Ishikura, Song-Gyu RA, Teruo Miyazaki, Hideaki Soya and Syumpei Miyakawa :
Effects of taurine supplementation on change of blood glucose and liver glycogen during and after exhaustive running,
19th International Taurine Meeting, Krakow-Poland, May 2014. Youngju Choi, Nobuhiko Akazawa, Asako Miyaki, Song-Gyu RA, Tomoko Matsubara and Seiji Maeda :
Sleep quality and arterial stiffness in middle-aged and older women,
5th World Congress on Sleep Medicine, Valencia, Sep. 2013. Song-Gyu RA, Seiji Maeda, Ryota Higashino, Tomoko Imai and Syumpei Miyakawa :
Metabolomics of salivary fatigue markers after 3 consecutive days of soccer game in male soccer players,
18th annual Congress of the European College of Sport Science, Barcelona, Jun. 2013. Koichiro Tanahashi, Nobuhiko Akazawa, Asako Miyaki, Youngju Choi, Song-Gyu RA, Tomoko Matsubara, Ryota Higashino, Hiroshi Kumagai, Satoshi Oikawa, Ryuichi Ajisaka and Seiji Maeda :
Effects of Aerobic Exercise Training on Plasma Asymmetric Dimethylarginine Concentration and Arterial Compliance in Postmenopausal Women,
18th annual Congress of the European College of Sport Science, Barcelona, Jun. 2013. Tomoko Matsubara, Asako Miyaki, Nobuhiko Akazawa, Youngju Choi, Song-Gyu RA, Ryota Higashino, Koichiro Tanahashi, Hiroshi Kumagai, Satoshi Oikawa, Ryuichi Ajisaka and Seiji Maeda :
The relationship between plasma klotho concentration and aerobic exercise capacity in postmenopausal women,
18th annual Congress of the European College of Sport Science, Barcelona, Jun. 2013. Hiroshi Kumagai, Asako Miyaki, Ryota Higashino, Nobuhiko Akazawa, Youngju Choi, Song-Gyu RA, Tomoko Matsubara, Koichiro Tanahashi, Miki Eto, Kiyoji Tanaka, Ryuichi Ajisaka and Seiji Maeda :
Lifestyle modification with exercise and diet improves serum testosterone level and aortic stiffness in overweight and obese men,
18th annual Congress of the European College of Sport Science, Barcelona, Jun. 2013. Nobuhiko Akazawa, Song-Gyu RA, Tomoko Matsubara, Youngju Choi, Koichiro Tanahashi, Asako Miyaki, Ryota Higashino, Hiroshi Kumagai, Satoshi Oikawa, Rryuichi Ajisaka and Seiji Maeda :
Aerobic exercise training lowers cerebral pulsatility index after acute aerobic exercise in middle-aged and older women,
18th annual Congress of the European College of Sport Science, Barcelona, Jun. 2013. Youngju Choi, Seiji Maeda, Asako Miyaki, Nobuhiko Akazawa, Song-Gyu RA, Hitoshi Shiraki and Ryuichi Ajisaka :
Effects of acute high-intensity resistance exercise on arterial compliance and vascular endothelial function,
2012 Commemorating the 88 Seoul Olympic Games International Sport Science Congress, Seoul, Aug. 2012. Song-Gyu RA, Teruo Miyazaki, Keisuke Ishikura, Hisashi Nagayama, Takafumi Suzuki, Seiji Maeda, Masaharu Ito, Yasushi Matsuzaki and Hajime Ohmori :
Additional effects of taurine on the benefits of BCAA intake for the delayed-onset-muscle-soreness and muscle-damage induced by high-intense eccentric exercise,
18th International Taurine Meeting, Marrakech-Morocco, Apr. 2012. Hajime Ohmori, D Aoki, Keisuke Ishikura, Song-Gyu RA, Takafumi Suzuki, Shoichi Komine, M Okido and Teruo Miyazaki :
Influence of increased blood ammonia by long duration running on the performance of calculation task,
12th International Congress on Amino Acids, Peptides and Proteins, Beijing, Aug. 2011. Song-Gyu RA, Teruo Miyazaki, Keisuke Ishikura, Takafumi Suzuki, Seiji Maeda, Syumpei Miyakawa, Yasushi Matsuzaki and Hajime Ohmori :
The combined effect of taurine with BCAA on the delayed-onset-muscle-soreness and damages after eccentric exercise a double-blind study,
12th International Congress on Amino Acids, Peptides and Proteins, Beijing, Aug. 2011. Song-Gyu RA, Teruo Miyazaki, Keisuke Ishikura, Takafumi Suzuki, Seiji Maeda, Syumpei Miyakawa, Yasushi Matsuzaki and Hajime Ohmori :
The combined effect of taurine with BCAA on the delayed-onset-muscle-soreness and damages after eccentric exercise a double-blind study,
12th International Congress on Amino Acids, Peptides and proteins, Beijing, Aug. 2011. 羅成圭, 三浦哉 :
下肢への骨格筋電気刺激が糖負荷後の血糖値と動脈スティフネスに及ぼす影響,
第31回日本運動生理学会大会, 2023年8月. 羅成圭, 志内哲也 :
タウリン摂取がマウス骨格筋の糖・脂質代謝関連因子へ及ぼす影響,
第9回国際タウリン研究会日本部会, 2023年3月. 羅成圭 :
スポーツ栄養学分野における研究成果を実践現場で活用するために,
第77回日本体力医学会大会, 2022年9月. 小峰昇一, 宮﨑照雄, 石倉恵介, 松井崇, 羅成圭, 本多彰, 征矢英昭, 宮川俊平, 大森肇 :
ラットにおけるタウリン摂取は脂肪酸酸化を促進し，長時間運動時の血糖低下を抑制する,
第8回国際タウリン研究会日本部会, 2022年3月. 羅成圭 :
Acute bout of exercise downregulates thioredoxin-interacting protein expression in rat contracting skeletal muscles,
第87回日本体力医学会中国・四国地方会, 2021年12月. 羅成圭, 本田紘基, 川中健太郎 :
運動後の非活動筋における糖取り込みとTXNIPの関与,
第76回日本体力医学会大会, 2021年9月. 田川要, 羅成圭, 吉川徹, 前田清司 :
一過性伸張性筋収縮運動は拡張期圧減衰の減速を伴い心筋灌流指標を改善させる,
第76回日本体力医学会大会, 2021年9月. 冨賀裕貴, 高橋宏和, 坂井一哉, 草野雅樹, 羅成圭, 川中健太郎, 安西慶三, 檜垣靖樹 :
運動で鍛えられた皮下白色脂肪細胞の移植がうつ・不安様行動に及ぼす影響,
第76回日本体力医学会大会, 2021年9月. 冨賀裕貴, 坂井一哉, 羅成圭, 草野雅貴, 伊藤愛, 上原吉就, 高橋宏和, 川中健太郎, 檜垣靖樹 :
短時間の走行運動による抗不安効果における分子機序と脂肪量との関連,
第28回西日本肥満研究会, 2021年7月. 佐野里奈, 三浦哉, 羅成圭, 東亜弥子, 石川みづき, 田村靖明, 出口純次, 久我浩正 :
高強度ジャンプエクササイズ後の回復方法の違いが筋の形状変化に及ぼす影響,
第75回日本体力医学会大会, 2020年9月. 久我浩正, 三浦哉, 羅成圭, 東亜弥子, 石川みづき, 田村靖明, 出口純次, 佐野里奈 :
下肢への骨格筋電気刺激と運動の併用が大腿動脈の血流量に及ぼす影響,
第75回日本体力医学会大会, 2020年9月. 本田絋基, 羅成圭, 飯澤拓樹, 中島志穂子, 冨賀裕貴, 檜垣靖樹, 木戸康平, 川中健太郎 :
受動的なストレッチはラットヒラメ筋のTXNIP発現量を減少させるとともにインスリン抵抗性を改善する,
第75回日本体力医学会大会, 2020年9月. 田川要, 羅成圭, 吉川徹, 前田清司 :
4週間の伸張性筋収縮運動が冠動脈灌流指標に及ぼす影響,
第75回日本体力医学会大会, 2020年9月. 冨賀裕貴, 坂井一哉, 伊藤愛, 羅成圭, 上原吉就, 川中健太郎, 檜垣靖樹 :
短期間の走運動は海馬BDNFのDNAメチル化レベルを低下させる,
第75回日本体力医学会大会, 2020年9月. 羅成圭, 崔英珠, 赤澤暢彦, 大森肇, 前田清司 :
経口タウリン摂取が高強度レジスタンス運動後の動脈機能へ及ぼす影響 ∼ヒト試験による検証∼,
体力科学, Vol.69, No.1, 126, 2020年.

(キーワード): Physical Therapy, Sports Therapy and Rehabilitation / Orthopedics and Sports Medicine
(出版サイトへのリンク): ● Publication site (DOI): 10.7600/jspfsm.69.126
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390283659843957248; ● Search Scopus @ Elsevier (DOI): 10.7600/jspfsm.69.126

(DOI: 10.7600/jspfsm.69.126, CiNii: 1390283659843957248) 羅成圭, 河本絵美, 越中敬一, 岩部万衣子, 冨賀裕貴, 飯澤拓樹, 本田紘基, 檜垣靖樹, 川中健太郎 :
一過性の運動は活動筋のTXNIP発現量を低下させる,
第74回日本体力医学会大会, 2019年9月. 本田紘基, 羅成圭, 飯澤拓樹, 冨賀裕貴, 川中健太郎 :
受動的な伸展状態はラットヒラメ筋のインスリン感受性に影響を及ぼす,
第74回日本体力医学会大会, 2019年9月. 崔英珠, 羅成圭, 田名辺陽子, 西嶋尚彦, 前田清司 :
アスリートにおけるクルクミン摂取が筋損傷および炎症マーカーに及ぼす影響,
第74回日本体力医学会大会, 2019年9月. 田川要, 崔英珠, 羅成圭, 吉川徹, 熊谷仁, 前田清司 :
若年男性における身長が高強度レジスタンストレーニングによる動脈伸展性の変化に及ぼす影響,
第74回日本体力医学会大会, 2019年9月. 羅成圭, 川中健太郎 :
経口タウリン摂取が発揮筋力ならびに筋持久力に及ぼす影響,
第27回日本運動生理学会大会, 2019年8月. 冨賀裕貴, 吉村咲紀, 高橋佑莉, 羅成圭, 川中健太郎, 上原吉就, 田中宏暁, 檜垣靖樹 :
内臓脂肪蓄積やエネルギー摂取量とうつ・不安行動調整因子である海馬神経型一酸化窒素合成酵素(nNOS)発現の関係,
第27回西日本肥満研究会, 2019年7月. 冨賀裕貴, 吉村咲紀, 高橋佑莉, 羅成圭, 川中健太郎, 上原吉就, 田中宏暁, 檜垣靖樹 :
肥満によるうつ・不安行動に対する運動の役割 -神経型一酸化窒素合成酵素(nNOS)と内臓脂肪に着目して-,
第21回七隈アルツハイマー病・パーキンソン病研究会, 2019年4月. 羅成圭, 中原未央, 川中健太郎 :
経口タウリン摂取がヒトの筋力に及ぼす影響,
第5回国際タウリン研究会日本部会, 2019年3月. 羅成圭, 中川洋成, 飯澤拓樹, 宗まりこ, 田中宏暁, 檜垣靖樹, 川中健太郎 :
老化にともなう骨格筋TXNIPタンパク質発現量と運動トレーニングの効果,
第73回日本体力医学会大会, 2018年9月. 宮﨑照雄, 中村優歩, 海老根慧, 羅成圭, 大森肇, 池上正, 松﨑靖司, 本多彰 :
N-アセチルタウリンによる骨格筋アセチルCoA量の調整,
第73回日本体力医学会大会, 2018年9月. 飯澤拓樹, 羅成圭, 安方惇, 本田紘基, 中川洋成, 西村恒星, 冨賀裕貴, 中島志穂子, 檜垣靖樹, 川中健太郎 :
摂取するタンパク質の種類の違いがラットの耐糖能力に及ぼす影響,
第73回日本体力医学会大会, 2018年9月. 河本絵美, 玉越敬悟, 羅成圭, 増田紘之, 川中健太郎 :
不活動はヒラメ筋のTXNIP遺伝子発現とインスリン抵抗性を誘導する,
第73回日本体力医学会大会, 2018年9月. 飯澤拓樹, 羅成圭, 川中健太郎 :
ホエイタンパク質摂取がラットの耐糖能力に与える影響,
第65回日本栄養改善学会学術総会, 2018年9月. 羅成圭, 河本絵美, 飯澤拓樹, 檜垣靖樹, 川中健太郎 :
運動トレーニングが骨格筋TXNIP発現量に及ぼす影響,
第26回日本運動生理学会大会, 2018年7月. 羅成圭 :
スポーツ科学分野におけるタウリン投与の効果に関するShort Review,
第4回国際タウリン研究会日本部会集会, 2018年3月. 田川要, 羅成圭, 熊谷仁, 澤野友里子, 山本晧策, 吉川徹, 吉田保子, 竹越一博, 前田清司 :
若年男性におけるレジスタンストレーニングが動脈伸展性および血中トロンボキサン濃度に及ぼす影響,
第72回日本体力医学会大会, 2017年9月. 中川洋成, 羅成圭, 冨賀裕貴, 中島志穂子, 田中宏暁, 檜垣靖樹, 川中健太郎 :
食餌中のビタミンD欠乏がラットの骨格筋量とインスリン情報伝達に及ぼす影響,
第72回日本体力医学会大会, 2017年9月. 羅成圭, 河本絵美, 中川洋成, 冨賀裕貴, 中島志穂子, 田中宏暁, 檜垣靖樹, 川中健太郎 :
筋線維タイプおよび運動トレーニングが骨格筋ビタミンD受容体発現量に及ぼす影響,
第72回日本体力医学会大会, 2017年9月. 中川洋成, 羅成圭, 冨賀裕貴, 中島志穂子, 田中宏暁, 檜垣靖樹, 川中健太郎 :
食餌中のビタミンD欠乏がラットの耐糖能力に及ぼす影響,
第71回日本栄養・食糧学会大会, 2017年5月. 羅成圭, 前田清司, 川中健太郎, 今井智子, 宮川俊平 :
運動誘発性疲労マーカーとしての唾液中タウリンの可能性,
第3回国際タウリン研究会日本部会集会, 2017年2月. 赤澤暢彦, 棚橋嵩一郎, 小崎恵生, 羅成圭, 松原朋子, 崔英珠, 膳法亜沙子, 前田清司 :
中高齢者における有酸素性トレーニングが一過性の有酸素性運動後の脳血流拍動性に及ぼす影響,
第71回日本体力医学会大会, 2016年9月. 宮崎照雄, 羅成圭, 石倉恵介, 宮川俊平, 松崎靖司, 本多彰, 大森肇 :
摂取後の運動による血中β-hydroxy-β-methylbutyrate(3HMB)濃度の上昇,
第71回日本体力医学会大会, 2016年9月. 時野谷勝幸, 石倉恵介, 羅成圭, 城本淳, 青木海, 森田将平, 吉田保子, 青柳篤, 鍋倉賢治, 竹越一博, 大森肇 :
長距離走中の早発性筋痛における筋損傷と炎症の継時的変化,
第71回日本体力医学会大会, 2016年9月. 時野谷勝幸, 石倉恵介, 菅澤威仁, 羅成圭, 城本淳, 青木海, 森田将平, 吉田保子, 青柳篤, 鍋倉賢治, 竹越一博, 大森肇 :
長距離走中の酸化ストレスマーカーおよび抗酸化力の経時的変化,
第69回日本酸化ストレス学会学術集会, 2016年8月. 時野谷勝幸, 羅成圭, 吉田一也, 吉田保子, 松村正隆, 竹越一博, 大森肇 :
高強度伸張性運動後の筋痛・筋損傷に対する繰り返し効果と炎症・発痛物質の関与,
第24回日本運動生理学会大会, 2016年7月. 宮崎照雄, 羅成圭, 海老名慧, 竹越一博, 宮川俊平, 大森肇 :
持久性運動後の酢酸に対するタウリンの生理的役割,
第24回日本運動生理学会大会, 2016年7月. 小崎恵生, 菅谷健, 棚橋嵩一郎, 澤野友里子, 赤澤暢彦, 羅成圭, 前田清司 :
中高齢者における定期的な運動がもたらす腎保護作用 –尿中L型脂肪酸結合蛋白に着目して-,
第6回日本腎臓リハビリテーション学会学術集会, 2016年3月. 石倉恵介, 小峰昇一, 羅成圭, 時野谷勝幸, 菅澤威仁, 鍋倉賢治, 吉岡利貢, 宮崎照雄, 竹越一博, 宮川俊平, 大森肇 :
マラソン誘発性筋損傷と炎症に対する分岐鎖アミノ酸投与の抑制効果,
第28回ランニング学会大会, 2016年3月. 中村優歩, 宮崎照雄, 羅成圭, 海老名慧, 菅澤威仁, 竹越一博, 宮川俊平, 本多彰, 松崎靖司, 大森肇 :
高強度持久性運動による骨格筋N-アセチルタウリンの増加,
第2回国際タウリン研究会日本部会, 2016年3月. 羅成圭, 崔英珠, 赤澤暢彦, 大森肇, 前田清司 :
タウリン摂取が一過性レジスタンス運動後の非運動肢血管内皮機能に及ぼす影響,
第2回国際タウリン研究会日本部会, 2016年3月. 栃木悠里子, 羅成圭, 目崎登, 宮川俊平, 福田崇, 前田清司 :
月経周期に伴う性ホルモンの変動が女性アスリートの骨格筋および腱の柔軟性に与える影響について,
第26回日本臨床スポーツ医学会学術集会, 2015年11月. 小崎恵生, 菅谷健, 羅成圭, 棚橋嵩一郎, 赤澤暢彦, 前田清司 :
中高齢者における尿中L-FABP濃度と心筋虚血(SEVR)の関連性,
第38回日本高血圧学会総会, 2015年10月. 時野谷勝幸, 石倉恵介, 海老名慧, 小峰昇一, 羅成圭, 川口優大, 黒岩貴信, 水島隆規, 山本大介, 鍋倉賢治, 宮川俊平, 大森肇 :
フルマラソンにおける速発性筋痛および筋損傷の特徴,
第70回日本体力医学会大会, 2015年9月. 羅成圭, 赤澤暢彦, 崔英珠, 大森肇, 前田清司 :
タウリン摂取が一過性伸張性運動後の非運動肢血管内皮機能に及ぼす影響,
第70回日本体力医学会大会, 2015年9月. 小崎恵生, 菅谷健, 羅成圭, 棚橋嵩一郎, 赤澤暢彦, 前田清司 :
中高齢者における尿中L-FABP濃度と運動能力の関連性,
第70回日本体力医学会大会, 2015年9月. 田川要, 赤澤暢彦, 吉川徹, 羅成圭, 棚橋嵩一郎, 熊谷仁, 矢野未来, 金美珍, 尹智暎, 大蔵倫博, 鈴木貴視, 小松美穂, 神村彩子, 前田清司 :
低体重高齢者における筋力トレーニングとL-シトルリン含有組成物摂取が動脈スティフネスに及ぼす影響,
第70回日本体力医学会大会, 2015年9月. 海老名慧, 小峰昇一, 大野貴弘, 時野谷勝幸, 石倉恵介, 松井崇, 羅成圭, 宮崎照雄, 宮川俊平, 征矢英昭, 大森肇 :
長時間運動時の遊離アミノ酸の動態にタウリン投与が及ぼす影響,
第70回日本体力医学会大会, 2015年9月. 栃木悠里子, 羅成圭, 赤澤暢彦, 菅村恵里香, 目崎登, 宮川俊平, 福田崇, 前田清司 :
女性アスリートにおける血清エストラジオールが安静時および運動中の認知機能に及ぼす影響,
第70回日本体力医学会大会, 2015年9月. 海老名慧, 小峰昇一, 大野貴弘, 時野谷勝幸, 石倉恵介, 松井崇, 羅成圭, 宮崎照雄, 宮川俊平, 征矢英昭, 大森肇 :
タウリン投与による長時間運動時の血糖維持∼遊離アミノ酸を基質とした糖新生の検討∼,
第23回日本運動生理学会大会, 2015年7月. 時野谷勝幸, 石倉恵介, 小峰昇一, 海老名慧, 羅成圭, 宮崎照雄, 宮川俊平, 大森肇 :
大森肇. 運動様式の違いによって生じる遅発性と速発性の筋痛・筋損傷の違い∼伸張性運動とフルマラソンによる検討∼,
第23回日本運動生理学会大会, 2015年7月. 大森肇, 小峰昇一, 三好貴士, 松井崇, 石倉恵介, 羅成圭, 宮崎照雄, 正田純一, 宮川俊平 :
長時間運動の持続時間と血糖レベルの関係に及ぼすタウリン投与の影響,
第1回国際タウリン研究会日本部会, 2015年2月. 海老名慧, 小峰昇一, 大野貴弘, 時野谷勝幸, 石倉恵介, 松井崇, 羅成圭, 宮崎照雄, 宮川俊平, 征矢英昭, 大森肇 :
長時間運動時の血糖低下をタウリン投与が抑制する機序 ∼遊離アミノ酸を基質とした糖新生からの検討∼,
第1回国際タウリン研究会日本部会, 2015年2月. 宮崎照雄, 石倉恵介, 本多彰, 羅成圭, 宮本和宣, 小峰昇一, 宮川俊平, 大森肇, 松崎靖司 :
持久性運動によるアセチルタウリンの生成,
第1回国際タウリン研究会日本部会, 2015年2月. 羅成圭, 崔英珠, 赤澤暢彦, 大森肇, 前田清司 :
タウリン摂取は伸張性レジスタンス運動後の遅発性筋肉痛と動脈スティフネスの増加を抑制する,
第1回国際タウリン研究会日本部会, 2015年2月. 石倉恵介, 宮崎照雄, 松坂賢, 羅成圭, 竹越一博, 宮川俊平, 大森肇 :
長時間持久走パフォーマンスに及ぼすタウリン投与の影響,
第1回国際タウリン研究会日本部会, 2015年2月. 崔英珠, 定宗隆一郎, 中村優希, 赤澤暢彦, 羅成圭, 熊谷仁, 前田清司 :
ジュニアアスリートにおける睡眠が運動技能の獲得に及ぼす影響,
第69回日本体力医学会大会, 2014年9月. 赤澤暢彦, 佐藤香穂, 羅成圭, 棚橋嵩一郎, 熊谷仁, 前田清司 :
剣道選手における強化合宿中のクルクミン摂取が分泌型免疫グロブリンAと心理的コンディションに及ぼす影響,
第69回日本体力医学会大会, 2014年9月. 羅成圭, 崔英珠, 赤澤暢彦, 大森肇, 前田清司 :
タウリン摂取は伸張性運動後の動脈スティフネスと酸化ストレスの増加を抑制する,
第69回日本体力医学会大会, 2014年9月. 石倉恵介, 小峰昇一, 羅成圭, 宮崎照雄, 宮川俊平, 大森肇 :
分岐鎖アミノ酸投与がフルマラソン後の酸化ストレス，抗酸化力へ及ぼす影響,
第69回日本体力医学会大会, 2014年9月. 羅成圭, 前田清司, 今井智子, 宮川俊平 :
運動誘発性疲労に伴い唾液中タウリン濃度は増加する,
第22回日本運動生理学会大会, 2014年7月. 羅成圭, 崔英珠, 赤澤暢彦, 大森肇, 前田清司 :
運動誘発性の動脈スティフネス増加に対する抗酸化サプリメント摂取の効果,
運動と循環研究会, 2014年7月. 羅成圭, 崔英珠, 赤澤暢彦, 松原朋子, 熊谷仁, 前田清司 :
閉経後の非肥満中高齢女性における睡眠の質と循環分岐鎖アミノ酸濃度の関係,
第68回日本体力医学会大会, 2013年9月. 中村優希, 崔英珠, 羅成圭, 吹田真士, 前田清司 :
バドミントン競技選手における睡眠の質が競技パフォーマンスに与える影響,
第68回日本体力医学会大会, 2013年9月. 崔英珠, 赤澤暢彦, 膳法亜沙子, 羅成圭, 松原朋子, 棚橋嵩一郎, 前田清司 :
中高齢女性における睡眠の質が動脈スティフネスに及ぼす影響,
第68回日本体力医学会大会, 2013年9月. 石倉恵介, 小峰昇一, 羅成圭, 宮崎照雄, 大森肇 :
分岐鎖アミノ酸投与がフルマラソン誘発性の血漿遊離アミノ酸濃度変化に及ぼす影響,
第68回日本体力医学会大会, 2013年9月. 小峰昇一, 石倉恵介, 松井崇, 羅成圭, 宮崎照雄, 宮川俊平, 征矢英昭, 大森肇 :
タウリン投与が走運動時の糖新生関連酵素に及ぼす影響,
第68回日本体力医学会大会, 2013年9月. 膳法(宮木) 亜沙子, 赤澤暢彦, 崔英珠, 羅成圭, 下條信威, 鰺坂隆一, 前田清司 :
中高齢女性における有酸素性運動トレーニングがTIMP-1およびFibulin-5の血中濃度に与える影響,
第68回日本体力医学会大会, 2013年9月. 石倉恵介, 小峰昇一, 羅成圭, 宮崎照雄, 大森肇 :
分岐鎖アミノ酸投与によるマラソン後の筋損傷と筋肉痛抑制効果,
第21回日本運動生理学会大会, 2013年7月. 熊谷仁, 膳法(宮木) 亜沙子, 羅成圭, 辻本健彦, 田中喜代次, 前田清司 :
血中テストステロン濃度と動脈コンプライアンスに及ぼす減量の影響:肥満者における検討,
第21回日本運動生理学会大会, 2013年7月. 羅成圭, 小峰昇一, 石倉恵介, 宮川俊平, 宮崎照雄, 大森肇 :
BCAA摂取タイミングの違いによる遅発性筋肉痛の抑制効果の違い,
第21回日本運動生理学会大会, 2013年7月. 小峰昇一, 石倉恵介, 松井崇, 羅成圭, 宮崎照雄, 宮川俊平, 征矢英昭, 大森肇 :
長時間走行の持続時間と血糖値へのタウリン投与の影響,
第21回日本運動生理学会大会, 2013年7月. 宮崎照雄, 羅成圭, 本多彰, 石倉恵介, 宮川俊平, 大森肇, 松崎靖司 :
骨格筋分岐鎖アミノ酸異化マーカーとしての血中3-ハイドロキシイソ酪酸測定の有用性,
第67回日本体力医学会, 2012年9月. 羅成圭, 東野亮太, 今井智子, 前田清司, 宮川俊平 :
メタボローム解析によるアスリートの唾液中疲労マーカーの網羅的探索,
第67回日本体力医学会, 2012年9月. 崔英珠, 前田清司, 宮木亜沙子, 赤澤暢彦, 羅成圭, 白木仁, 鰺坂隆一 :
一過性の高強度筋力運動が血流依存性血管拡張と血流低下由来の血管収縮に及ぼす影響,
第67回日本体力医学会, 2012年9月. 小峰昇一, 石倉恵介, 鈴木隆文, 松井崇, 羅成圭, 宮崎照雄, 宮川俊平, 征矢英昭, 大森肇 :
長時間運動中の血糖低下をタウリン投与により抑制するラットモデルの作製,
第67回日本体力医学会, 2012年9月. 石倉恵介, 宮崎照雄, 羅成圭, 大森肇 :
BCAA製剤服用の水泳競技・フルマラソン後の筋肉痛に対する軽減効果,
第20回日本運動生理学会, 2012年7月. 羅成圭, 崔英珠, 宮木亜沙子, 赤澤暢彦, 鰺坂隆一, 前田清司 :
高強度レジスタンス運動後の収縮期血圧と血中シトルリンおよびオルニチン濃度の関係,
第20回日本運動生理学会, 2012年7月. 東野亮太, 宮木亜沙子, 崔英珠, 赤澤暢彦, 羅成圭, 田名辺陽子, 辻本健彦, 蘇リナ, 田中喜代次, 鰺坂隆一, 前田清司 :
肥満男性における生活習慣改善が中心血圧に及ぼす影響,
第12回臨床血圧脈波研究会, 2012年6月. 羅成圭, 宮崎照雄, 石倉恵介, 鈴木隆文, 前田清司, 宮川俊平, 大森肇 :
タウリンとBCAAの併用摂取による伸張性運動前後の血漿アミノ酸濃度の変化,
第66回日本体力医学会, 2011年9月. 大森肇, 石倉恵介, 宮崎照雄, 羅成圭, 小峰昇一, 宮川俊平 :
運動後のラット骨格筋アミノ酸濃度に及ぼすタウリン投与の影響と濃度依存性,
第66回日本体力医学会, 2011年9月. 石倉恵介, 宮崎照雄, 羅成圭, 大森肇 :
トレーニング期の食事制限がラット骨格筋アミノ酸濃度変化に及ぼす影響,
第66回日本体力医学会, 2011年9月. 羅成圭, 宮崎照雄, 石倉恵介, 大森肇 :
一定期間のBCAAとタウリンの併用摂取が伸張性運動後の筋痛に及ぼす効果,
第65回日本体力医学会, 2010年9月.

研究会・報告書

羅成圭, 古瀬裕次郎, 冨賀裕貴 :
高齢者における体力・認知能力と血中ビタミンの関係,
福岡大学研究部論集. F, 推奨研究編 : 推奨研究プロジェクト成果報告書 = The bulletin of Central Research Institute Fukuoka University. Series F, Recommended research : result reports of the recommended research project, Vol.8, 83-87, 2020年12月.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1050850424362212736

(CiNii: 1050850424362212736) 羅成圭, 畑本陽一 :
不活動と運動が骨格筋ビタミンD受容体発現量と糖取り込みに及ぼす影響,
福岡大学研究部論集. F, 推奨研究編 : 推奨研究プロジェクト成果報告書 = The bulletin of Central Research Institute Fukuoka University, Vol.7, 93-96, 2019年12月.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1050565162619910400

(CiNii: 1050565162619910400)

特許: 研究者総覧に該当データはありませんでした。
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補助金・競争的資金: 食後高血糖による動脈機能低下に対する骨格筋電気刺激の効果と作用機序 (研究課題/領域番号: 23K10586 )
活動筋への血糖供給を高める血糖再配分機構の解明－非活動筋の糖取り込みに着目して－ (研究課題/領域番号: 20K11326 )
除脂肪量増加に有効な食事処方に関する基礎的研究 (研究課題/領域番号: 19H04013 )
老化とともに骨格筋や脳が委縮する分子機構ならびに運動による防止効果 (研究課題/領域番号: 18K17811 )
ビタミンDと運動が骨格筋ミトコンドリア新生ならびに品質管理機能に及ぼす影響 (研究課題/領域番号: 16K16571 )
インスリンと運動が脳の血糖取り込みに及ぼす影響 (研究課題/領域番号: 16K13024 )
骨格筋糖取り込みを高める栄養・運動処方に関する基礎研究　－ビタミンDに着目して－ (研究課題/領域番号: 16H03244 )
血管内皮前駆細胞の増殖・活性化に着目した抗動脈硬化運動プログラムの確立 (研究課題/領域番号: 15J00614 )
タウリン摂取がレジスタンス運動後の動脈スティフネスに与える効果とその機序の解明 (研究課題/領域番号: 13J00711 )
研究者番号（60741999）による検索

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研究者総覧で最新データを確認する

2024年4月30日更新

専門分野・研究分野: 運動栄養学
運動生理学 (Exercise Physiology)
運動生化学
分子栄養学 (Molecular Nutrition)
所属学会・所属協会: 日本体力医学会
日本運動生理学会
European College of Sport Science
国際タウリン研究会日本部会
日本体育・スポーツ・健康学会
American Physiological Society
International Taurine Society
日本フットボール学会
委員歴・役員歴: 日本体力医学会 (評議員 [2009年4月〜])
日本運動生理学会 (評議員 [2009年4月〜])
European College of Sport Science ( [2010年4月〜])
国際タウリン研究会日本部会 (理事 [2014年4月〜])
日本体育・スポーツ・健康学会 (編集委員 [2023年4月〜2025年3月])
American Physiological Society ( [2018年4月〜])
International Taurine Society ( [2021年6月〜])
日本フットボール学会 ( [2022年11月])
受賞: 2011年2月, 最優秀論文発表賞(単独) (筑波大学大学院運動生理学・生化学領域)
2012年5月, 研究奨励賞(単独) (一般財団法人成和記念財団)
2013年7月, 第21回日本運動生理学会大会奨励賞(筆頭) (日本運動生理学会)
2014年3月, 優秀論文賞(単独) (筑波大学)
2019年7月, 第27回西日本肥満研究会コメディカル部門最優秀演題賞(共同) (西日本肥満研究会)
2019年9月, 日本体力医学会2018-2019 国際学術交流奨励賞(単独) (日本体力医学会)
2021年12月, 令和2年度日本体力医学会中国・四国地方会奨励賞(筆頭) (日本体力医学会中国・四国地方会)
2022年11月, 教養教育賞(単独) (教養教育院)
2023年4月, 教養教育賞(単独) (教養教育院)
2024年4月, 教養教育賞(単独) (教養教育院)
活動: 福岡大学エクステンションセンター市民カレッジ「キッズ・サッカークラブ」 (講師 [2015年4月〜2020年3月])
教養教育実務者連絡会委員 (2020年4月)
FD委員会委員 (2020年4月〜2021年3月)
教務委員会オブザーバー (2020年4月〜2021年3月)
教務委員会委員 (2021年4月〜)
常三島地区安全衛生委員会委員 (2024年4月〜2026年3月)

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Ｊグローバル

Jグローバル最終確認日: 2024/4/27 01:06
氏名（漢字）: 羅成圭
氏名（フリガナ）: ラソンギュ
氏名（英字）: RA Song-Gyu
所属機関: 徳島大学准教授

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researchmap最終確認日: 2024/4/28 04:04
氏名（漢字）: 羅成圭
氏名（フリガナ）: ラソンギュ
氏名（英字）: RA Song-Gyu
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登録日時: 2016/2/19 14:11
更新日時: 2024/4/17 19:07
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所属ID: 0344000000
所属: 徳島大学
部署: 教養教育院
職名: 准教授
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学位授与機関: 筑波大学
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学歴
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2024年4月27日更新

研究者番号: 60741999

所属（現在）: 2024/4/1 : 徳島大学, 教養教育院, 准教授

所属（過去の研究課題 情報に基づく）*注記: 2020/4/1 – 2023/4/1 : 徳島大学, 教養教育院, 准教授
2021/4/1 : 福岡大学, スポーツ科学部, 助教
2016/4/1 – 2019/4/1 : 福岡大学, スポーツ科学部, 助教
2015/4/1 : 筑波大学, 医学医療系, 特別研究員(PD)
2014/4/1 : 筑波大学, 体育系, 特別研究員(PD)

審査区分/研究分野

研究代表者

総合系 / 複合領域 / 健康・スポーツ科学 / スポーツ科学
総合領域 / 健康・スポーツ科学 / 応用健康科学
健康・スポーツ科学 / 応用健康科学(A)
小区分59020:スポーツ科学関連

研究代表者以外

総合系 / 複合領域 / 健康・スポーツ科学 / スポーツ科学
小区分59020:スポーツ科学関連

キーワード

研究代表者

ビタミンD / ミトコンドリア新生 / ミトコンドリアダイナミクス / ミトコンドリア品質管理 / 運動 / 品質管理 / 分裂 / ミトコンドリア / 融合 / アポトーシス / 骨格筋 / チオレドキシン相互作用タンパク質 / 脳 / 老化 / チオレドキシン結合タンパク質 / 血糖 / 糖取り込み / 非活動筋 / TXNIP / AMPK / ストレスホルモン / 食後高血糖 / 動脈スティフネス / 骨格筋電気刺激 / タウリン / レジスタンス運動 / 酸化ストレス / 伸張性運動 / 血管内皮前駆細胞 / 動脈機能

研究代表者以外

ビタミンD / 骨格筋 / 糖代謝 / 筋量 / ミトコンドリア / PGC-1α / Akt / ラット / ビタミンD受容体 / 持久性トレーニング / 代償性負荷 / 筋肥大 / 糖取り込み / 運動 / GLUT4 / 速筋線維 / 遅筋線維 / 血糖値 / インスリン / 耐糖能力 / インスリン抵抗性 / 内臓脂肪 / 老化 / 脳 / ワートマニン / デキサメタゾン / 2-deoxyglucose / 乳酸閾値 / 糖質コルチコイド / 海馬 / エネルギー付加 / 糖質付加 / タンパク質付加 / 体タンパク質 / 除脂肪 / 筋タンパク質合成 / 除脂肪量 / 体水分量 / 固型除脂肪量 / 体タンパク質量 / 水中体重法 / 重水希釈法 / DXA法 / タンパク質 / エネルギー / リボソーム / ロイシン / グルコース / 筋タンパク質合成速度 / p70S6キナーゼ / 体脂肪量 / 増量

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羅 成圭

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研究代表者

研究代表者以外

研究代表者

研究代表者以外

羅成圭