研究者を探す
津田 正史
高知大学
2025年4月4日更新
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- 専門分野・研究分野
- 薬系化学、創薬科学
2025年4月4日更新
- 専門分野・研究分野
- 薬系化学、創薬科学
- 担当経験のある授業科目
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2025年4月4日更新
- 専門分野・研究分野
- 薬系化学、創薬科学
- 研究テーマ
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- 論文
- Total Synthesis, Stereochemical Revision, and Biological Assessment of Iriomoteolide-2a Keita Sakamoto, Akihiro Hakamata, Arihiro Iwasaki, Kiyotake Suenaga, Masashi Tsuda, Haruhiko Fuwa Chemistry - A European Journal 25 8528-8542 20190626-
Total Synthesis and Stereochemical Revision of Iriomoteolide-2a Keita Sakamoto, Akihiro Hakamata, Masashi Tsuda, Haruhiko Fuwa Angewandte Chemie - International Edition 57 3801-3805 20180326-
Iriomoteolides-9a and 11a: two new odd-numbered macrolides from the marine dinoflagellate Amphidinium species Keiko Kumagai, Masayuki Tsuda, Eri Fukushi, Jun Kawabata, Atsunori Masuda, Masashi Tsuda Journal of Natural Medicines 71 506-512 20170701-
Stereodivergent Synthesis and Configurational Assignment of the C1-C15 Segment of Amphirionin-5 Moemi Kanto, Sota Sato, Masashi Tsuda, Makoto Sasaki Journal of Organic Chemistry 81 9105-9121 20161007-
Iriomoteolides-10a and 12a, cytotoxic macrolides from marine dinoflagellate Amphidinium species Mai Akakabe, Keiko Kumagai, Masayuki Tsuda, Yuko Konishi, Akira Tominaga, Daisuke Kaneno, Eri Fukushi, Jun Kawabata, Atsunori Masuda, Masashi Tsuda Chemical and Pharmaceutical Bulletin 64 1019-1023 20160101-
Mellpaladines and dopargimine, novel neuroactive guanidine alkaloids from a Palauan Didemnidae tunicate Hajime Uchimasu, Ken Matsumura, Masashi Tsuda, Keiko Kumagai, Mai Akakabe, Masaki J. Fujita, Ryuichi Sakai Tetrahedron 72 7185-7193 20160101-
Effect of an introduced phytoene synthase gene expression on Carotenoid biosynthesis in the marine diatom Phaeodactylum tricornutum Takashi Kadono, Nozomu Kira, Kengo Suzuki, Osamu Iwata, Takeshi Ohama, Shigeru Okada, Tomohiro Nishimura, Mai Akakabe, Masashi Tsuda, Masao Adachi Marine Drugs 13 5334-5357 20150801-
Amphirionin-2, a novel linear polyketide with potent cytotoxic activity from a marine dinoflagellate Amphidinium species Keiko Kumagai, Mika Minamida, Mai Akakabe, Masayuki Tsuda, Yuko Konishi, Akira Tominaga, Masashi Tsuda, Eri Fukushi, Jun Kawabata Bioorganic and Medicinal Chemistry Letters 25 635-638 20150201-
Iriomoteolide-2a, a cytotoxic 23-membered macrolide from marine benthic dinoflagellate amphidinium species Keiko Kumagai, Masashi Tsuda, Atsunori Masuda, Eri Fukushi, Jun Kawabata Heterocycles 91 265-274 20150101-
Amphirionin-4 with potent proliferation-promoting activity on bone marrow stromal cells from a marine dinoflagellate Amphidinium species Mika Minamida, Keiko Kumagai, Dana Ulanova, Mai Akakabe, Yuko Konishi, Akira Tominaga, Hidenori Tanaka, Masayuki Tsuda, Eri Fukushi, Jun Kawabata, Atsunori Masuda, Masashi Tsuda Organic Letters 16 4858-4861 20140919-
Amphirionin-5, a novel linear polyketide from a cultured marine dinoflagellate Amphidinium species with a potent cell proliferation-promoting activity Masashi Tsuda, Mai Akakabe, Keiko Kumagai, Masayuki Tsuda, Yuko Konishi, Akira Tominaga, Eri Fukushi, Jun Kawabata Tetrahedron Letters 55 3491-3494 20140611-
Direct and stereospecific interaction of amphidinol 3 with sterol in lipid bilayers Rafael Atillo Espiritu, Nobuaki Matsumori, Masashi Tsuda, Michio Murata Biochemistry 53 3287-3293 20140527-
Iriomoteolide-13a, a cytotoxic 22-membered macrolide from a marine dinoflagellate Amphidinium species Mai Akakabe, Keiko Kumagai, Yuko Konishi, Akira Tominaga, Masashi Tsuda, Eri Fukushi, Jun Kawabata, Masayuki Tsuda Tetrahedron 70 2962-2965 20140506-
Salinispora arenicola from temperate marine sediments: New intra-species variations and atypical distribution of secondary metabolic genes Kian Sim Goo, Masashi Tsuda, Dana Ulanova Antonie van Leeuwenhoek, International Journal of General and Molecular Microbiology 105 207-219 20140101-
Iriomoteolides-4A and -5A, hydrophilic macrolides from marine dinoflagellate amphidinium species Keiko Kumagai, Masashi Tsuda, Eri Fukushi, Jun Kawabata Heterocycles 87 2615-2623 20131210-
A platform for designing hyperpolarized magnetic resonance chemical probes Hiroshi Nonaka, Ryunosuke Hata, Tomohiro Doura, Tatsuya Nishihara, Keiko Kumagai, Mai Akakabe, Masashi Tsuda, Kazuhiro Ichikawa, Shinsuke Sando Nature Communications 4
Synthesis and hyperpolarized <sup>15</sup>N NMR studies of <sup>15</sup>N-choline-d<inf>13</inf> Keiko Kumagai, Kazuyasu Kawashima, Mai Akakabe, Masayuki Tsuda, Takamasa Abe, Masashi Tsuda Tetrahedron 69 3896-3900 20130513-
Stereochemistry of theonezolides A-C Kohei Nozawa, Masashi Tsuda, Naonobu Tanaka, Takaaki Kubota, Eri Fukushi, Jun Kawabata, Jun'Ichi Kobayashi Tetrahedron Letters 54 783-787 20130220-
Hyrtioseragamines A and B, new alkaloids from the sponge hyrtios species Yohei Takahashi, Yoshiro Iinuma, Takaaki Kubota, Masashi Tsuda, Mitsuhiro Sekiguchi, Yuzuru Mikami, Jane Fromont, Jun'Ichi Kobayashi Organic Letters 13 628-631 20110218-
Benzosceptrin C, a new dimeric bromopyrrole alkaloid from sponge Agelas sp. Takaaki Kubota, Atsushi Araki, Tetsuro Yasuda, Masashi Tsuda, Jane Fromont, Kazuki Aoyama, Yuzuru Mikami, Markus R. W?lchli, Jun'ichi Kobayashi Tetrahedron Letters 50 7268-7270 20091230-
Effects of temperature, photosynthetic photon flux density, photoperiod and O<inf>2</inf> and CO<inf>2</inf> concentrations on growth rates of the symbiotic dinoflagellate, Amphidinium sp. Y. Kitaya, L. Xiao, A. Masuda, T. Ozawa, M. Tsuda, K. Omasa Journal of Applied Phycology 20 737-742 20081001-
Nagelamides K and L, dimeric bromopyrrole alkaloids from sponge Agelas species Atsushi Araki, Takaaki Kubota, Masashi Tsuda, Yuzuru Mikami, Jane Fromont, Jun'ichi Kobayashi Organic Letters 10 2099-2102 20080605-
Iriomoteolide-3a, a cytotoxic 15-membered macrolide from a marine dinoflagellate Amphidinium species Keiko Oguchi, Masashi Tsuda, Rie Iwamoto, Yumiko Okamoto, Jun'Ichi Kobayashi, Eri Fukushi, Jun Kawabata, Tomoko Ozawa, Atsunori Masuda, Yoshiaki Kitaya, Kenji Omasa Journal of Organic Chemistry 73 1567-1570 20080215-
Seragadine A, A β-carboline alkaloid from marine sponge Kohei Nozawa, Masashi Tsuda, Takaaki Kubota, Jane Fromont, Jun'ichi Kobayashia Heterocycles 74 849-853 20071231-
Iriomoteolides-1b and -1c, 20-membered macrolides from a marine dinoflagellate Amphidinium species Masashi Tsuda, Keiko Oguchi, Rie Iwamoto, Yumiko Okamoto, Eri Fukushi, Jun Kawabata, Tomoko Ozawa, Atsunori Masuda Journal of Natural Products 70 1661-1663 20071001-
Amphidinolides B6 and B7, cytotoxic macrolides from a symbiotic dinoflagellate Amphidinium species Keiko Oguchi, Masashi Tsuda, Rie Iwamoto, Yumiko Okamoto, Taeko Endo, Jun'ichi Kobayashi, Tomoko Ozawa, Atsunori Masuda Journal of Natural Products 70 1676-1679 20071001-
Iriomoteolide-1a, a potent cytotoxic 20-membered macrolide from a benthic dinoflagellate Amphidinium species Masashi Tsuda, Keiko Oguchi, Rie Iwamoto, Yumiko Okamoto, Jun'ichi Kobayashi, Eri Fukushi, Jun Kawabata, Tomoko Ozawa, Atsunori Masuda, Yoshiaki Kitaya, Kenji Omasa Journal of Organic Chemistry 72 4469-4474 20070608-
Nagelamide J, a novel dimeric bromopyrrole alkaloid from a sponge agelas species Atsushi Araki, Masashi Tsuda, Takaaki Kubota, Yuzuru Mikami, Jane Fromont, Ju N.ichi Kobayashi Organic Letters 9 2369-2371 20070607-
Hyrtinadine A, a bis-indole alkaloid from a marine sponge Taeko Endo, Masashi Tsuda, Jane Fromont, Jun'ichi Kobayashi Journal of Natural Products 70 423-424 20070301-
Agesamides A and B, bromopyrrole alkaloids from sponge Agelas species: Application of DOSY for chemical screening of new metabolites Masashi Tsuda, Tetsuro Yasuda, Eri Fukushi, Jun Kawabata, Mitsuhiro Sekiguchi, Jane Fromont, Jun'ichi Kobayashi Organic Letters 8 4235-4238 20060914-
Amphezonol A, a novel polyhydroxyl metabolite from marine dinoflagellate Amphidinium sp. Takaaki Kubota, Yusuke Sakuma, Kazutaka Shimbo, Masashi Tsuda, Michiko Nakano, Yasuhiro Uozumi, Jun'ichi Kobayashi Tetrahedron Letters 47 4369-4371 20060626-
Absolute stereochemistry and antitumor activity of iejimalides Kohei Nozawa, Masashi Tsuda, Haruaki Ishiyama, Takuma Sasaki, Takashi Tsuruo, Jun'ichi Kobayashi Bioorganic and Medicinal Chemistry 14 1063-1067 20060215-
Metachromins J and K, new sequiterpenoids from marine sponge Spongia species Yohei Takahashi, Masashi Tsuda, Jane Fromont, Jun'ichi Kobayashi Heterocycles 67 791-796 20060201-
Amphidinin B, a new polyketide metabolite from marine dinoflagellate Amphidinium sp. Takaaki Kubota, Tetsuya Endo, Yohei Takahashi, Masashi Tsuda, Jun'ichi Kobayashi Journal of Antibiotics 59 512-516 20060101-
Luteophanol D, new polyhydroxyl metabolite from marine dinoflagellate Amphidinium sp. Takaaki Kubota, Ayako Takahashi, Masashi Tsuda, Jun'ichi Kobayashi Marine Drugs 3 113-118 20051201-
Absolute stereochemistry of citrinadins A and B from marine-derived fungus Takao Mugishima, Masashi Tsuda, Yuu Kasai, Haruaki Ishiyama, Eri Fukushi, Jun Kawabata, Masayuki Watanabe, Kenichi Akao, Jun'ichi Kobayashi Journal of Organic Chemistry 70 9430-9435 20051111-
Perinadine A, a novel tetracyclic alkaloid from marine-derived fungus Penicillium citrinum Mai Sasaki, Masashi Tsuda, Mitsuhiro Sekiguchi, Yuzuru Mikami, Jun'ichi Kobayashi Organic Letters 7 4261-4264 20050915-
Solution conformations of amphidinolide H Kazutaka Shimbo, Kohei Nozawa, Masashi Tsuda, Jun'ichi Kobayashi Bioorganic and Medicinal Chemistry 13 5066-5071 20050901-
Dendridine A, a Bis-indole alkaloid from a marine sponge Dictyodendrilla species Masashi Tsuda, Yohei Takahashi, Jane Fromont, Yuzuru Mikami, Jun'Ichi Kobayashi Journal of Natural Products 68 1277-1278 20050801-
Gesashidine A, a β-carboline alkaloid with an imidazole ring from a thorectidae sponge Yoshiro Iinuma, Shingo Kozawa, Haruaki Ishiyama, Masashi Tsuda, Eri Fukushi, Jun Kawabata, Jane Fromont, Jun'ichi Kobayashi Journal of Natural Products 68 1109-1110 20050701-
Cladionol A, a polyketide glycoside from marine-derived fungus Gliocladium species Yuu Kasai, Kazusei Komatsu, Hideyuki Shigemori, Masashi Tsuda, Yuzuru Mikami, Jun'ichi Kobayashi Journal of Natural Products 68 777-779 20050501-
SAR studies of brasilicardin A for immunosuppressive and cytotoxic activities Kazusei Komatsu, Masashi Tsuda, Yasushi Tanaka, Yuzuru Mikami, Jun'ichi Kobayashi Bioorganic and Medicinal Chemistry 13 1507-1513 20050301-
Brasilibactin A, a cytotoxic compound from actinomycete Nocardia brasiliensis Masashi Tsuda, Masaaki Yamakawa, Seiko Oka, Yasushi Tanaka, Yasutake Hoshino, Yuzuru Mikami, Ayumi Sato, Hironori Fujiwara, Yasushi Ohizumi, Jun'ichi Kobayashi Journal of Natural Products 68 462-464 20050301-
Amphidinolides B4 and B5, potent cytotoxic 26-membered macrolides from dinoflagellate Amphidinium species Masashi Tsuda, Yuuko Kariya, Rie Iwamoto, Eri Fukushi, Jun Kawabata, Jun'ichi Kobayashi Marine Drugs 3 43838 20050301-
Scalusamides A-C, new pyrrolidine alkaloids from the marine-derived fungus Penicillium citrinum Masashi Tsuda, Mai Sasaki, Takao Mugishima, Kazusei Komatsu, Teruo Sone, Michiko Tanaka, Yuzuru Mikami, Jun'ichi Kobayashi Journal of Natural Products 68 273-276 20050201-
Asymmetric synthesis of double bond isomers of the structure proposed for pyrinodemin A and indication of its structural revision Molecules 10 312-316 20050101-
Brasilicardins B-D, new tricyclic terpernoids from actinomycete Nocardia brasiliensis Kazusei Komatsu, Masashi Tsuda, Motoo Shiro, Yasushi Tanaka, Yuzuru Mikami, Jun'Ichi Kobayashi Bioorganic and Medicinal Chemistry 12 5545-5551 20041101-
Synthesis of the proposed structure of plakevulin A: Revised structure of plakevulin A Fumiyo Saito, Ryo Takeuchi, Tomoyuki Kamino, Kouji Kuramochi, Fumio Sugawara, Kengo Sakaguchi, Susumu Kobayashi, Masashi Tsuda, Jun'Ichi Kobayashi Tetrahedron Letters 45 8069-8071 20041018-
Citrinadin A, a novel pentacyclic alkaloid from marine-derived fungus Penicillium citrinum Masashi Tsuda, Yuu Kasai, Kazusei Komatsu, Teruo Sone, Michiko Tanaka, Yuzuru Mikami, Jun'ichi Kobayashi Organic Letters 6 3087-3089 20040902-
Amphidinolide H, a potent cytotoxic macrolide, covalently binds on actin subdomain 4 and stabilizes actin filament Takeo Usui, Sayaka Kazami, Naoshi Dohmae, Yoshikazu Mashimo, Hisae Kondo, Masashi Tsuda, Asako Goi Terasaki, Kazuyo Ohashi, Jun'Ichi Kobayashi, Hiroyuki Osada Chemistry and Biology 11 1269-1277 20040901-
Nagelamides A-H, new dimeric bromopyrrole alkaloids from marine sponge Agelas species Tadashi Endo, Masashi Tsuda, Tadashi Okada, Shinya Mitsuhashi, Hiroshi Shima, Kunimi Kikuchi, Yuzuru Mikami, Jane Fromont, Jun'ichi Kobayashi Journal of Natural Products 67 1262-1267 20040801-
Inhibitory activity of mazamenone A and plakoridine A against DNA polymerases Marinela Perpelescu, Masashi Tsuda, Motoshi Suzuki, Shonen Yoshida, Jun'ichi Kobayashi Natural Medicines 58 86 20040401-
Absolute Stereochemistry of Immunosuppressive Macrolide Brasilinolide A and Its New Congener Brasilinolide C Kazusei Komatsu, Masashi Tsuda, Yasushi Tanaka, Yuzuru Mikami, Jun'ichi Kobayashi Journal of Organic Chemistry 69 1535-1541 20040305-
Amphidinolides, bioactive macrolides from symbiotic marine dinoflagellates Jun'ichi Kobayashi, Masashi Tsuda Natural Product Reports 21 77-93 20040201-
Bioactive products from Okinawan marine micro- and macroorganisms J. Kobayashi, M. Tsuda Phytochemistry Reviews 3 267-274 20040101-
Sporiolides A and B, new cytotoxic twelve-membered macrolides from a marine-derived fungus cladosporium species Hideyuki Shigemori, Yuu Kasai, Kazusei Komatsu, Masashi Tsuda, Yuzuru Mikami, Jun'ichi Kobayashi Marine Drugs 2 164-169 20040101-
Amphidinolide Y, a Novel 17-Membered Macrolide from Dinoflagellate Amphidinium sp.: Plausible Biogenetic Precursor of Amphidinolide X Masashi Tsuda, Naoko Izui, Kazutaka Shimbo, Masaaki Sato, Eri Fukushi, Jun Kawabata, Jun'ichi Kobayashi Journal of Organic Chemistry 68 9109-9112 20031114-
Amphidinolide X, a novel 16-membered macrodiolide from dinoflagellate Amphidinium sp Masashi Tsuda, Naoko Izui, Kazutaka Shimbo, Masaaki Sato, Eri Fukushi, Jun Kawabata, Kazuhito Katsumata, Takeo Horiguchi, Jun'ichi Kobayashi Journal of Organic Chemistry 68 5339-5345 20030627-
Speradine A, a new pentacyclic oxindole alkaloid from a marine-derived fungus Aspergillus tamarii Masashi Tsuda, Takao Mugishima, Kazusei Komatsu, Teruo Sone, Michiko Tanaka, Yuzuru Mikami, Motoo Shiro, Manabu Hirai, Yasushi Ohizumi, Jun'ichi Kobayashi Tetrahedron 59 3227-3230 20030428-
Absolute stereochemistry of amphidinolide C: Synthesis of C-1-C-10 and C-17-C-29 segments Takaaki Kubota, Masashi Tsuda, Jun'ichi Kobayashi Tetrahedron 59 1613-1625 20030303-
Modiolides A and B, two new 10-membered macrolides from a marine-derived fungus Masashi Tsuda, Takao Mugishima, Kazusei Komatsu, Teruo Sone, Michiko Tanaka, Yuzuru Mikami, Jun'ichi Kobayashi Journal of Natural Products 66 412-415 20030301-
Plakevulin A, a new oxylipin inhibiting DNA polymerases α and γ from sponge Plakortis species Masashi Tsuda, Tadashi Endo, Marinela Perpelescu, Shonen Yoshida, Kenji Watanabe, Jane Fromont, Yuzuru Mikami, Jun'ichi Kobayashi Tetrahedron 59 1137-1141 20030217-
Stereochemistry of iejimalide B Masashi Tsuda, Kohei Nozawa, Kazutaka Shimbo, Haruaki Ishiyama, Eri Fukushi, Jun Kawabata, Jun'ichi Kobayashi Tetrahedron Letters 44 1395-1399 20030210-
Rigidins B-D, new pyrrolopyrimidine alkaloids from a tunicate Cystodytes species Masashi Tsuda, Kohei Nozawa, Kazutaka Shimbo, Jun'ichi Kobayashi Journal of Natural Products 66 292-294 20030201-
Bioactive macrolides and polyketides from marine dinoflagellates Jun'ichi Kobayashi, Kazutaka Shimbo, Takaaki Kubota, Masashi Tsuda Pure and Applied Chemistry 75 337-342 20030101-
Application of modified Mosher's method for primary alcohols with a methyl group at C2 position Masashi Tsuda, Yuki Toriyabe, Tetsuya Endo, Jun'ichi Kobayashi Chemical and Pharmaceutical Bulletin 51 448-451 20030101-
Nakirodin A, a bromotyrosine alkaloid from a verongid sponge Masashi Tsuda, Tadashi Endo, Kenji Watanabe, Jane Fromont, Jun'Ichi I. Kobayashi Journal of Natural Products 65 1670-1671 20021101-
Luffariolides H and J, new sesterterpenes from a marine sponge Luffariella species Masashi Tsuda, Tadashi Endo, Yuzuru Mikami, Jane Fromont, Jun'ichi Kobayashi Journal of Natural Products 65 1507-1508 20021001-
Amphidinolides H2-H5, G2, and G3, new cytotoxic 26- and 27-membered macrolides from dinoflagellate Amphidinium sp. Jun'ichi Kobayashi, Kazutaka Shimbo, Masaaki Sato, Masashi Tsuda Journal of Organic Chemistry 67 6585-6592 20020920-
Biosynthetic study of amphidinolide W Masashi Tsuda, Naoko Izui, Masaaki Sato, Jun'ichi Kobayashi Chemical and Pharmaceutical Bulletin 50 976-977 20020701-
Absolute stereochemistry of amphidinolide E Takaaki Kubota, Masashi Tsuda, Jun'ichi Kobayashi Journal of Organic Chemistry 67 1651-1656 20020308-
Amphidinolide W, a new 12-membered macrolide from dinoflagellate Amphidinium sp. Kazutaka Shimbo, Masashi Tsuda, Naoko Izui, Jun'ichi Kobayashi Journal of Organic Chemistry 67 1020-1023 20020208-
Biosynthetic study of amphidinolide B M. Tsuda, T. Kubota, Y. Sakuma, J. Kobayashi Chemical and Pharmaceutical Bulletin 49 1366-1367 20011117-
Suberedamines A and B, new bromotyrosine alkaloids from a sponge Suberea species M. Tsuda, Y. Sakuma, J. Kobayashi Journal of Natural Products 64 980-982 20010820-
Amphidinolide T5, a new 19-membered macrolide from a dinoflagellate and X-ray structure of amphidinolide T1 Takaaki Kubota, Tetsuya Endo, Masashi Tsuda, Motoo Shiro, Jun'Ichi Kobayashi Tetrahedron 57 6175-6179 20010716-
Biosynthetic study of amphidinolide C Takaaki Kubota, Masashi Tsuda, Jun'ichi Kobayashi Tetrahedron 57 5975-5977 20010709-
Absolute stereochemistry of amphidinolide C Takaaki Kubota, Masashi Tsuda, Jun'ichi Kobayashi Organic Letters 3 1363-1366 20010503-
Amphidinolides T2, T3, and T4, new 19-membered macrolides from the dinoflagellate Amphidinium sp. and the biosynthesis of amphidinolide T1 J. Kobayashi, T. Kubota, T. Endo, M. Tsuda Journal of Organic Chemistry 66 134-142 20010112-
Ma'edamines A and B, cytotoxic bromotyrosine alkaloids with a unique 2(1H)pyrazinone ring from sponge Suberea sp. Keiko Hirano, Takaaki Kubota, Masashi Tsuda, Kenji Watanabe, Jane Fromont, Jun'ichi Kobayashi Tetrahedron 56 8107-8110 20001006-
Dytesinins A and B, new clerodane-type diterpenes with a cyclopropane ring from the tunicate Cystodytes sp. Kazutaka Shimbo, Masashi Tsuda, Eri Fukushi, Jun Kawabata, Jun'ichi Kobayashi Tetrahedron 56 7923-7926 20000929-
Absolute stereochemistry of amphidinolides G and H Jun'ichi Kobayashi, Kazutaka Shimbo, Masaaki Sato, Motoo Shiro, Masashi Tsuda Organic Letters 2 2805-2807 20000907-
Amphidinolide T, novel 19-membered macrolide from marine dinoflagellate Amphidinium sp. Masashi Tsuda, Tetsuya Endo, Jun'ichi Kobayashi Journal of Organic Chemistry 65 1349-1352 20000310-
Amphidinolide V, novel 14-membered macrolide from marine dinoflagellate Amphidinium sp. Takaaki Kubota, Masashi Tsuda, Jun'ichi Kobayashi Tetrahedron Letters 41 713-716 20000129-
Biosynthetic studies of amphidinolides G and H: Unusual labeling patterns in feeding experiments with <sup>13</sup>C-labeled acetates Masaaki Sato, Kazutaka Shimbo, Masashi Tsuda, Jun'Ichi Kobayashi Tetrahedron Letters 41 503-506 20000122-
Colopsinols D and E, new polyhydroxyl linear carbon chain compounds from marine dinoflagellate Amphidinium sp. Takaaki Kubota, Masashi Tsuda, Miho Takahashi, Masami Ishibashi, Seiko Oka, Jun'ichi Kobayashi Chemical and Pharmaceutical Bulletin 48 1447-1451 20000101-
Pyrinodemins B - D, potent cytotoxic bis-pyridine alkaloids from marine sponge Amphimedon sp. Keiko Hirano, Takaaki Kubota, Masashi Tsuda, Yuzuru Mikami, Jun'ichi Kobayashi Chemical and Pharmaceutical Bulletin 48 974-977 20000101-
Amphidinolide U, novel 20-membered macrolide from marine dinoflagellate Amphidinium sp. Masashi Tsuda, Tetsuya Endo, Jun'ichi Kobayashi Tetrahedron 55 14565-14570 19991217-
Colopsinols B and C, new long chain polyhydroxy compounds from cultured marine dinoflagellate Amphidinium sp. Takaaki Kubota, Masashi Tsuda, Miho Takahashi, Masami Ishibashi, Hideo Naoki, Jun'ichi Kobayashi Journal of the Chemical Society - Perkin Transactions 1 3483-3487 19991207-
Nocarasins A-C and brasiliquinone D, new metabolites from the actinomycete Nocardia brasiliensis Masashi Tsuda, Akira Nemoto, Hisayuki Komaki, Yasushi Tanaka, Katsukiyo Yazawa, Yuzuru Mikami, Jun'ichi Kobayashi Journal of Natural Products 62 1640-1642 19991201-
Mukanadins A-C, new bromopyrrole alkaloids from marine sponge Agelas nakamurai Hiroshi Uemoto, Masashi Tsuda, Jun'ichi Kobayashi Journal of Natural Products 62 1581-1583 19991101-
Keramamides M and N, two new cyclic peptides with a sulfate ester from Theonella sponge Masashi Tsuda, Haruaki Ishiyama, Kanami Masuko, Toshifumi Takao, Yasutsugu Shimonishi, Jun'ichi Kobayashi Tetrahedron 55 12543-12548 19991022-
Two theonellapeptolide congeners from marine sponge Theonella sp. Masashi Tsuda, Kazutaka Shimbo, Takaaki Kubota, Yuzuru Mikami, Jun'ichi Kobayashi Tetrahedron 55 10305-10314 19990820-
Slagenins A ~ C, novel bromopyrrole alkaloids from marine sponge Agelas nakamurai Masashi Tsuda, Hiroshi Uemoto, J. Kobayashi Tetrahedron Letters 40 5709-5712 19990730-
Pyrinodemin A, a cytotoxic pyridine alkaloid with an isoxazolidine moiety from sponge Amphimedon sp. Masashi Tsuda, Keiko Hirano, Takaaki Kubota, Jun'ichi Kobayashi Tetrahedron Letters 40 4819-4820 19990625-
Synthesis of C-1 ~ C-13 segment of amphidinolide B Haruaki Ishiyama, Takahiro Takemura, Masashi Tsuda, Jun'ichi Kobayashi Tetrahedron 55 4583-4594 19990409-
Colopsinol A, a novel polyhydroxyl metabolite from marine dinoflagellate Amphidinium sp. Jun'ichi Kobayashi, Takaaki Kubota, Miho Takahashi, Masami Ishibashi, Masashi Tsuda, Hideo Naoki Journal of Organic Chemistry 64 1478-1482 19990305-
Synthesis of the C-14-C-26 segment of amphidinolide B Haruaki Ishiyama, Takahiro Takemura, Masashi Tsuda, Ju N.Ichi Kobayashi Journal of the Chemical Society - Perkin Transactions 1 1163-1166 19990101-
A new manzamine congener from marine sponge Amphimedon sp. Masashi Tsuda, Daisuke Watanabe, Jun'ichi Kobayashi Heterocycles 50 485-488 19990101-
Luteophanols B and C, new polyhydroxyl compounds from marine dinoflagellate Amphidinium sp. Takaaki Kubota, Masashi Tsuda, Yukiko Doi, Ayako Takahashi, Hiroko Nakamichi, Masami Ishibashi, Eri Fukushi, Jun Kawabata, Jun'ichi Kobayashi Tetrahedron 54 14455-14464 19981126-
Rhopaladins A ~ D, new indole alkaloids from marine tunicate Rhopalaea sp. Hiroyasu Sato, Masashi Tsuda, Kenji Watanabe, Jun'ichi Kobayashi Tetrahedron 54 8687-8690 19980723-
Keramamides K and L, new cyclic peptides containing unusual tryptophan residue from Theonella sponge Hiroshi Uemoto, Yumi Yahiro, Hideyuki Shigemori, Masashi Tsuda, Toshifumi Takao, Yasutsugu Shimonishi, Jun'ichi Kobayashi Tetrahedron 54 6719-6724 19980611-
Ma'eganedin A, a new manzamine alkaloid from Amphimedon sponge Masashi Tsuda, Daisuke Watanabe, Jun'ichi Kobayashi Tetrahedron Letters 39 1207-1210 19980305-
Synthesis of two diastereomers of C-1 - C-14 segment in amphidinolide L Jun'ichi Kobayashi, Akiko Hatakeyama, Masashi Tsuda Tetrahedron 54 697-704 19980129-
Synthesis of a diastereoisomer of the C-15-C-26 segment of amphidinolide L Masashi Tsuda, Akiko Hatakeyama, Jun'ichi Kobayashi Journal of the Chemical Society - Perkin Transactions 1 149-155 19980107-
Spongiacidins A-D, new bromopyrrole alkaloids from Hymeniacidon sponge K. Inaba, H. Sato, M. Tsuda, J. Kobayashi Journal of Natural Products 61 693-695 19980101-
Three new manzamine congeners from Amphimedon sponge D. Watanabe, M. Tsuda, J. Kobayashi Journal of Natural Products 61 689-692 19980101-
Tauroacidins A and B, new bromopyrrole alkaloids possessing a taurine residue from Hymeniacidon sponge Jun'ichi Kobayashi, Kenjiro Inaba, Masashi Tsuda Tetrahedron 53 16679-16682 19971208-
Structures and biogenesis of manzamines and related alkaloids Masashi Tsuda, Jun'ichi Kobayashi Heterocycles 46 765-794 19971201-
Nakadomarin A, a Novel Hexacyclic Manzamine-Related Alkaloid from Amphimedon Sponge Ju N.Ichi Kobayashi, Daisuke Watanabe, Naoko Kawasaki, Masashi Tsuda Journal of Organic Chemistry 62 9236-9239 19971201-
Konbu'acidin A, a new bromopyrrole alkaloid with cdk4 inhibitory activity from Hymeniacidon sponge Jun'ichi Kobayashi, Minako Suzuki, Masashi Tsuda Tetrahedron 53 15681-15684 19971117-
Brasilidine A, a new cytotoxic isonitrile-containing indole alkaloid from the actinomycete Nocardia brasiliensis J. Kobayashi, M. Tsuda, A. Nemoto, Y. Tanaka, K. Yazawa, Y. Mikami Journal of Natural Products 60 719-720 19970812-
Unique ring systems and biogenetic path of manzamine alkaloids Jun'ichi Kobayashi, Masashi Tsuda Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry 55 1114-1123 19970101-
Halishigamides A-D, new cytotoxic oxazole-containing metabolites from Okinawan sponge Halichondria sp. Jun'ichi Kobayashi, Masashi Tsuda, Hitomi Fuse, Takuma Sasaki, Yuzuru Mikami Journal of Natural Products 60 150-154 19970101-
Brasiliquinones A, B and C, new benz[a]anthraquinone antibiotics from Nocardia brasiliensis. I. Producing strain, isolation and biological activities of the antibiotics Akira Nemoto, Yasushi Tanaka, Yasumi Karasaki, Hisayuki Komaki, Katsukiyo Yazawa, Yuzuru Mikami, Takashi Tojo, Kiyoshi Kadowaki, Masashi Tsuda, Jun'ichi Kobayashi Journal of Antibiotics 50 18-21 19970101-
Absolute stereochemistry of keramaphidin B Jun'ichi Kobayashi, Naoko Kawasaki, Masashi Tsuda Tetrahedron Letters 37 8203-8204 19961104-
Absolute stereochemistry of penaresidins A and B Jun'ichi Kobayashi, Masashi Tsuda, Jie Fei Cheng, Masami Ishibashi, Hirosato Takikawa, Kenji Mori Tetrahedron Letters 37 6775-6776 19960909-
Brasiliquinones A-C, new cytotoxic benz[a]anthraquinones with an ethyl group at C-3 from actinomycete Nocardia brasiliensis Masashi Tsuda, Hiroyasu Sato, Yasushi Tanaka, Katsukiyo Yazawa, Yuzuru Mikami, Takuma Sasaki, Jun'ichi Kobayashi Journal of the Chemical Society - Perkin Transactions 1 1773-1775 19960807-
Jaspiferals A ? G, new cytotoxic isomalabaricane-type nortriterpenoids from Okinawan marine sponge Jaspis stellifera Jun'ichi Kobayashi, Kyoko Yuasa, Takayuki Kobayashi, Takuma Sasaki, Masashi Tsuda Tetrahedron 52 5745-5750 19960415-
Chiral resolution of (±)-keramaphidin B and isolation of mamamine L, a new β-carboline alkaloid from a sponge Amphimedon sp. Masashi Tsuda, Kenjiro Inaba, Naoko Kawasaki, Kaori Honma, Jun'ichi Kobayashi Tetrahedron 52 2319-2324 19960212-
Hymenamide F, new cyclic heptapeptide from marine sponge Hymeniacidon sp. Jun'ichi Kobayashi, Takemichi Nakamura, Masashi Tsuda Tetrahedron 52 6355-6360 19960101-
Aplysillamides A and B, new antimicrobial guanidine alkaloids from the Okinawan marine sponge Psammaplysilla purea Kaori Honma, Masashi Tsuda, Yuzuru Mikami, Jun'ichi Kobayashi Tetrahedron 51 3745-3748 19950327-
Purealidins J?R, New Bromotyrosine Alkaloids from the Okinawan Marine Sponge Psammaplysilla purea Jun’ichi Kobayashi, Kaori Honma, Masashi Tsuda, Takuma Sasaki Chemical and Pharmaceutical Bulletin 43 403-407 19950101-
Lipopurealins D and E and Purealidin H, new bromotyrosine alkaloids from the okinawan marine sponge psammaplysilla purea Jun'ichi Kobayashi, Kaori Honma, Masashi Tsuda, Toshiyuki Kosaka Journal of Natural Products 58 467-470 19950101-
6-Hydroxymanzamine A and 3,4-dihydromanzamine A, new alkaloids from the okinawan marine sponge amphimedon sp. Jun'ichi Kobayashi, Masashi Tsuda, Naoko Kawasaki, Takuma Sasaki, Yuzuru Mikami Journal of Natural Products 57 1737-1740 19941201-
Amphidinolide L, a New Cytotoxic 27-Membered Macrolide from the Cultured Dinoflagellate Amphidinium sp. Masashi Tsuda, Takuma Sasaki, Jun'ichi Kobayashi Journal of Organic Chemistry 59 3734-3737 19940701-
Keramaphidin B, a novel pentacyclic alkaloid from a marine sponge Amphimedon sp. : A plausible biogenetic precursor of manzamine alkaloids Jun'ichi Kobayashi, Masashi Tsuda, Naoko Kawasaki, Keita Matsumoto, Takashi Adachi Tetrahedron Letters 35 4383-4386 19940620-
Keramaphidin C and keramamine C plausible biogenetic precursors of manzamine C from an Okinawan marine sponge Masashi Tsuda, Naoko Kawasaki, Jun'ichi Kobayashi Tetrahedron Letters 35 4387-4388 19940620-
Hymenamides G, H, J, and K, four new cyclic octapeptides from the Okinawan marine sponge Hymeniacidon sp. Masashi Tsuda, Takuma Sasaki, Jun'ichi Kobayashi Tetrahedron 50 4667-4680 19940418-
Ircinols A and B, first antipodes of manzamine-related alkaloids from an Okinawan marine sponge Masashi Tsuda, Naoko Kawasaki, Jun'ichi Kobayashi Tetrahedron 50 7957-7960 19940101-
Hymenamides C ~ E, new cyclic heptapeptides with two proline residues from the okinawan marine sponge hymeniacidon sp. Masashi Tsuda, Hideyuki Shigemori, Yuzuru Mikami, Jun'ichi Kobayashi Tetrahedron 49 6785-6796 19930730-
Hymenamides a and b, new proline-rich cyclic heptapeptides from the okinawan marine sponge hymeniacidon sp. Jun'ichi Kobayashi, Masashi Tsuda, Takemichi Nakamura, Yuzuru Mikami, Hideyuki Shigemori Tetrahedron 49 2391-2402 19930319-
Purealidins E?G, new bromotyrosine alkaloids from the okinawan marine sponge psammaplysilla purea Masashi Tsuda, Hideyuki Shigemori, Masami Ishibashi, Jun'ichi Kobayashi Journal of Natural Products 55 1325-1327 19920901-
Luffariolides A-E, New Cytotoxic Sesterterpenes from the Okinawan Marine Sponge Luffariella sp. Masashi Tsuda, Hideyuki Shigemori, Masami Ishibashi, Takuma Sasaki, Jun'ichi Kobayashi Journal of Organic Chemistry 57 3503-3507 19920601-
Purealidin D, a new pyridine alkaloid from the okinawan marine sponge psammaplysilla purea Masashi Tsuda, Hideyuki Shigemori, Masami Ishibashi, Jun'ichi Kobayashi Tetrahedron Letters 33 2597-2598 19920428-
Cystodytins D-I, new cytotoxic tetracyclic aromatic alkaloids from the okinawan marine tunicate cystodytes dellechiajei Junichi Kobayashi, Masashi Tsuda, Asako Tanabe, Masami Ishibashi, Jie Fei Cheng, Shosuke Yamamura, Takuma Sasaki Journal of Natural Products 54 1634-1638 19911101-
Purealidins B and C, new bromotyrosine alkaloids from the okinawan marine sponge psammaplysilla purea Jun'ichi Kobayashi, Masashi Tsuda, Kaori Agemi, Hideyuki Shigemori, Masami Ishibashi, Takuma Sasaki, Yuzuru Mikami Tetrahedron 47 6617-6622 19910812-
A potent actomyosin ATPase activator from the Okinawan marine sponge Agelas cf. nemoechinata J. Kobayashi, M. Tsuda, Y. Ohizumi Experientia 47 301-304 19910301-
Purealidin A, a new cytotoxic bromotyrosine-derived alkaloid from the Okinawan marine sponge Psammaplysilla purea M. Ishibashi, M. Tsuda, Y. Ohizumi, T. Sasaki, J. Kobayashi Experientia 47 299-300 19910301-
Amphidinolide F, A new cytotoxic macrolide from the marine dinoflagellate amphidinium sp. Junichi Kobayashi, Masashi Tsuda, Masami Ishibashi, Hideyuki Shigemori, Terufumi Yamasu, Hiroshi Hirota, Takuma Sasaki The Journal of Antibiotics 44 1259-1261 19910101-
Stelliferins A-F, new antineoplastic isomalabaricane triterpenes from the Okinawan marine sponge Jaspis stellifera. Masashi Tsuda, Masami Ishibashi, Kaori Agemi, Takuma Sasaki, Jun'ichi Kobayashi Tetrahedron 47 2181-2194 19910101-
Two caffeic acid tetramers having enantiomeric phenyldihydronaphthalene moieties from Macrotomia euchroma Makoto Nishizawa, Masashi Tsuda, Koji Hayashi Phytochemistry 29 2645-2649 19900101-
Ageliferins, potent actomyosin Atpase activators from the Okinawan marine sponge Agelas sp Jun'ichi Kobayashi, Masashi Tsuda, Tetsuya Murayama, Hideshi Nakamura, Yasushi Ohizumi, Masami Ishibashi, Michiko Iwamura, Tomihisa Ohta, Shigeo Nozoe Tetrahedron 46 5579-5586 19900101- - MISC
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- イリオモテオリド-1aの全合成研究：側鎖の不斉中心の立体配置 尾花知紘, 中島美結, 中里一貴, 中川颯人, 村田佳亮, 津田正史, 不破春彦 2024.3.18 - 2024.3.21 日本薬学会
イリオモテオリド-1aの全合成研究 花知紘, 中里一貴, 中川颯人, 津田正史, 不破春彦 2023.7.19 - 2023.7.20 有機合成化学協会
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2025年4月4日更新
- 専門分野・研究分野
- 薬系化学、創薬科学
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2025年3月30日更新
2025年4月5日更新
Ｊグローバル
- Jグローバル最終確認日
- 2025/4/5 01:07
- 氏名（漢字）
- 津田 正史
- 氏名（フリガナ）
- JグローバルAPIで取得できませんでした。
- 氏名（英字）
- Tsuda Masashi
- 所属機関
- 高知大学 教授
リサーチマップ
- researchmap最終確認日
- 2025/3/30 02:14
- 氏名（漢字）
- 津田 正史
- 氏名（フリガナ）
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- Tsuda Masashi
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- 登録日時
- 2019/11/13 17:12
- 更新日時
- 2024/10/24 10:45
- アバター画像URI
- https://researchmap.jp/1738751/avatar.jpg
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- 0520029014
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- 高知大学
- 部署
- 教育研究部 総合科学系 複合領域科学部門
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- 博士（薬学）
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- 北海道大学
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2025年4月5日更新
- 研究者番号
- 10261322
- 所属（現在）
- 2024/4/1 : 高知大学, 教育研究部総合科学系複合領域科学部門, 教授
- 所属（過去の研究課題
情報に基づく）*注記 - 2020/4/1 – 2024/4/1 : 高知大学, 教育研究部総合科学系複合領域科学部門, 教授
2016/4/1 – 2018/4/1 : 高知大学, 教育研究部総合科学系複合領域科学部門, 教授
2014/4/1 : 高知大学, 教育研究部総合科学系, 教授
2009/4/1 – 2011/4/1 : 高知大学, 教育研究部・総合科学系, 教授
2006/4/1 : 北海道大学, 大学院薬学研究院, 助教授
2004/4/1 – 2005/4/1 : 北海道大学, 大学院・薬学研究科, 助教授
2001/4/1 – 2002/4/1 : 北海道大学, 大学院・薬学研究科, 助教授
1998/4/1 – 2000/4/1 : 北海道大学, 大学院・薬学研究科, 助手
1995/4/1 – 1997/4/1 : 北海道大学, 薬学部, 教務職員
- 審査区分/研究分野
-
研究代表者
医学 / 薬学 / 化学系薬学
生物系 / 医歯薬学 / 薬学 / 化学系薬学
生物系 / 医歯薬学 / 薬学 / 天然資源系薬学
総合・新領域系 / 複合新領域 / 生体分子科学 / 生物分子科学
生物系
理工系
超高齢社会研究
小区分47050:環境および天然医薬資源学関連研究代表者以外
医学 / 薬学 / 化学系薬学
総合・新領域系 / 複合新領域 / 生体分子科学 / 生物分子科学
理工系
- キーワード
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研究代表者
マクロリド / 不斉炭素 / 相対立体配置 / 不斉エポキシ化反応 / 絶対立体配置 / クロスカップリング反応 / Wittig反応 / 抗腫瘍性 / 構造活性相関 / 渦鞭毛藻 / 不斉ジオール化反応 / Keck法 / サイクリン依存性キナーゼ / ブロモチロシンアルカロイド / ビスピリジンアルカロイド / 細胞毒性 / 海洋由来真菌 / アルカロイド / 殺細胞活性 / 二次代謝産物 / 細胞増殖促進活性 / 動的核偏極 / 遺伝子プローブ / 迅速探索法 / macrolide / dinoflagellate / cytotoxic / 生物活性物質 / 細胞増殖阻害 / 天然活性物質 / 細胞増殖活性 / 磁気共鳴イメージング / 有用二次代謝産物 / 構造解析 / 全合成
研究代表者以外
海洋天然物 / 海綿 / ホヤ / 渦鞭毛藻 / マクロリド / ペプチド / β-カルボリン / 立体化学 / アルカロイド / 合成 / アンフィジノリドL / セオネゾリドA / 立体異性体 / 絶対立体配置 / 天然物 / Ca^<2+>遊離 / カフェイン / β-カルボリンアルカロイド / 結合蛋白質 / アフィニティカラム / フォトアフィニティ / MBED / 海洋生物 / 一酸化窒素(NO) / 一酸化窒素合成酵素(NOS) / NOS阻害物質 / 炎症 / 共生藻 / Amphidinium / 殺細胞活性 / 生合成 / 構造活性相関 / 共渦鞭毛藻 / イエジマリド / Eudistoma cf.rigida / ポリケチド合成酵素 / コスミドライブラリー / 抗イエジマリド抗体 / アクチン / チューブリン / 分子標的 / 天然資源 / リード化合物 / 日本産イチイ / 多剤耐性 / P-糖蛋自質 / 耐性克服物質 / 抗腫瘍活性 / タキソイド / 微小管脱重合阻害 / P-糖蛋白質 / タキシニン / Japanese yew / multidrug-resistance / glycoprotein / tubulin / MDR modifier / antitumor / taxoids / inhibition of microtubule depolymerization / 未利用生物資源 / 薬物の開発 / サプリメント / 北方系植物 / 海洋微生物 / エゾユズリハ / 健康補助食品 / 生活習慣病 / 北海道 / ハイイヌガヤ / symbiotic dinoflagellate / drug discovery / supplement / plants of northern districts / marine organism / marine microorganism / macrolide / absolute configuration / biosynthesis / Actin / Tubulin / Molecular Target / Natural Resource / Read Compound
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