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若槻哲三

徳島大学

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2024年12月23日更新

職名: 准教授
電話: 088-633-7124
電子メール: wakatuki@clin.med.tokushima-u.ac.jp
学歴: 1988/3: 徳島大学医学部医学科卒業
1992/3: 徳島大学大学院医学研究科博士課程単位取得退学
1993/2: 徳島大学大学院医学研究科博士課程修了
学位: 博士(医学) (徳島大学) (1993年2月)
職歴・経歴: 1993/4: 東邦大学医学部第三内科常勤研究生
1994/10: 徳島大学医学部附属病院医員
1999/10: 徳島大学医学部助手
2001/3: 徳島大学医学部附属病院医員
2002/7: 徳島大学医学部附属病院助手

専門分野・研究分野: 内科学 (Internal Medicine)
循環器病学 (Cardiovascular Medicine)

研究者総覧で最新データを確認する

2024年12月23日更新

専門分野・研究分野: 内科学 (Internal Medicine)
循環器病学 (Cardiovascular Medicine)
担当経験のある授業科目: 内科学第二 (学部)
循環器コース(3年) (学部)
疾病学2 (学部)
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研究者総覧で最新データを確認する

2024年12月23日更新

専門分野・研究分野: 内科学 (Internal Medicine)
循環器病学 (Cardiovascular Medicine)

研究テーマ: 冠循環動態に関する病態生理学的研究, 虚血再灌流心筋の機能改善·保護に関する研究, 冠動脈硬化と局所炎症·局所温に関する研究, 冠動脈内皮機能に関する研究 (冠血流, 冠内圧, 冠動脈内局所温度, 急性心筋梗塞, 冠動脈硬化, 冠動脈不安定プラーク)

著書

若槻哲三 :
急性(前壁中隔)心筋梗塞，急性(下壁)心筋梗塞，急性(側壁)心筋梗塞，心内膜下梗塞,
株式会社メジカルビュー社, 東京, 2022年3月. 若槻哲三 :
Q20 カテーテル治療で血小板凝集機能は亢進する?,
南江堂, 東京, 2016年12月. 若槻哲三 :
胸痛 (Chapter 1 症候),
医歯薬出版株式会社, 東京, 2014年5月. 島袋充生, M Dagvasumberel, 石田昌義, 松本幸子, 小塚智沙代, 平良伸一, 屋比久浩市, 八木秀介, 福田大受, 山田博胤, 添木武, 若槻哲三, 親泊政一, 益埼裕章, 佐田政隆 :
異所性脂肪と2型糖尿病・心臓血管病【特集生活の質(QOL:Quality of life)を高める医療最前線ー難治な病気に光明が見えた!ー】,
徳島医学会, 徳島, 2013年4月.

(要約): There is evidence supporting the notion that excess abdominal fat is predictive of insulin resistance and the presence of related metabolic abnormalities currently referred to as the metabolic syndrome (MetS). Despite the fact that abdominal obesity is a highly prevalent feature of MetS, the mechanisms by which abdominal obesity is causally related to MetS are not fully elucidated. Besides visceral fat accumulation, ectopic lipid deposition, especially in the liver and skeletal muscle, has been implicated in the pathophysiology of diabetes, insulin resistance and obesity-related disorders. In addition, ectopic fat deposition play a critical role in the heart components such as (1) circulatory and locally recruited fat, (2) intra-and extra-myocellular fat, (3) perivascular fat, and (4) pericardial fat. In this review, the contribution of ectopic lipid deposition to global cardiometabolic risk is discussed via possible mechanisms including adipocytokine, insulin resistance and lipotoxicity.
(キーワード): Ectopic fat deposition / Diabetes mellitus / Cardiovascular diseases / Obesity / Metabolic syndrome / Lipotoxicity
(徳島大学機関リポジトリ): ● Metadata: 109609
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1050302172854384256

(徳島大学機関リポジトリ: 109609, CiNii: 1050302172854384256) 若槻哲三 :
第4章代表的な病態の読み方,
株式会社医学出版, 東京, 2012年9月. 若槻哲三 :
更なる動画ネットワークシステムの活用への過程-今後への期待も含めて,
株式会社エム・イー振興協会, 東京, 2011年1月. 若槻哲三 :
Q112. 心内膜下梗塞の心電図の特徴を教えてください,
株式会社メジカルビュー社, 東京, 2010年6月. 若槻哲三 :
Q110. 急性(側壁)心筋梗塞の心電図の特徴を教えてください,
株式会社メジカルビュー社, 東京, 2010年6月. 若槻哲三 :
Q109. 急性(下壁)心筋梗塞の心電図の特徴はなんですか?どこをみればよいですか?,
株式会社メジカルビュー社, 東京, 2010年6月. 若槻哲三 :
Q108. 急性(前壁中隔)心筋梗塞の心電図の特徴を教えてください,
株式会社メジカルビュー社, 東京, 2010年6月. 大木崇, 森一博, 若槻哲三, 山田博胤, 福田信夫 :
心エコー·ドプラ法の臨床第2版,
株式会社医学書院, 東京, 2001年9月. 若槻哲三, 大木崇 :
標準循環器病学·後天性弁膜疾患,
株式会社医学書院, 東京, 2001年. 若槻哲三, 大木崇 :
循環器症候群·洞停止,
日本臨牀社, 大阪, 1996年. 若槻哲三, 山口徹 :
虚血性心疾患·虚血性心疾患における新しい治療,
金原出版株式会社, 東京, 1996年.

論文

Masaaki Hayashi, Takeshi Soeki, Yasuhiro Noda, Daiki Tamagami, Keisuke Morinishi, Yusuke Chikata, Tomoko Takahashi, Tomomi Matsuura, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Hirotsugu Yamada, Tetsuzo Wakatsuki and Masataka Sata :
Risk Factors for Intraoperative Instability in Sedated Patients Undergoing Pulmonary Vein Isolation Ablation,
International Heart Journal, Vol.65, No.6, 1020-1024, 2024.

(要約): Persistent or paroxysmal atrial fibrillation is typically treated with pulmonary vein isolation (PVI) ablation under deep sedation with propofol. Intraoperative hemodynamic or respiratory instability often interferes with the surgical procedure. We retrospectively investigated risk factors in 80 patients who underwent their first PVI ablation for atrial fibrillation at our hospital. Background and echocardiography findings were collected from their electronic charts and the questionnaires they completed during hospitalization. Total intraoperative propofol dose and bolus injections (total number and volume) were defined as surrogate measures of patient instability. Single and stepwise multiple regression were performed using each measure as the dependent variable. When total propofol dose was employed as the dependent variable, significant associations were observed with drinking status (P < 0.05) and body mass index (BMI) (P < 0.05). When total number or volume of intravenous propofol boluses were each used as the dependent variable, significant associations were noted with age (P < 0.05) and BMI (P < 0.05). Separately, statistical analyses were conducted using total propofol dose or total number of bolus injections as the dependent variable and echocardiography parameters as independent variables. A significant association was detected between total dose and left atrial dimension (P < 0.05). These results suggested that younger age, higher BMI (obesity), and current drinking status adversely affect patient stability under deep sedation. To ensure safe ablation, physicians should pay attention to these risk factors when administering deep sedation for PVI.
(キーワード): Humans / Male / Atrial Fibrillation / Female / Pulmonary Veins / Middle Aged / Risk Factors / Retrospective Studies / Propofol / Catheter Ablation / Aged / Deep Sedation / Body Mass Index / Intraoperative Complications / Echocardiography
(徳島大学機関リポジトリ): ● Metadata: 119657
(出版サイトへのリンク): ● Publication site (DOI): 10.1536/ihj.24-152
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 39537166; ● Search Scopus @ Elsevier (PMID): 39537166; ● Search Scopus @ Elsevier (DOI): 10.1536/ihj.24-152

(徳島大学機関リポジトリ: 119657, DOI: 10.1536/ihj.24-152, PubMed: 39537166) Shusuke Yagi, Ryosuke Miyamoto, Masayoshi Tasaki, Hiroyuki Morino, Ryuji Otani, Muneyuki Kadota, Takayuki Ise, Hiroki Yamazaki, Kenya Kusunose, Koji Yamaguchi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Daiju Fukuda, Mitsuharu Ueda and Masataka Sata :
The APOA1 p.Leu202Arg variant potentially causes autosomal recessive cardiac amyloidosis.,
Human Genome Variation, Vol.11, No.1, 2024.

(要約): ApoA-I amyloidosis is an extremely rare form of systemic amyloidosis that commonly involves the heart, kidneys, and liver. ApoA-I amyloidosis is caused by amyloidogenic variants of APOA1 that are inherited in an autosomal dominant manner. Here, we report a 69-year-old man with sporadic cardiac amyloidosis who was born to consanguineous parents and carried a homozygous variant of p.Leu202Arg in APOA1.
(徳島大学機関リポジトリ): ● Metadata: 119580
(出版サイトへのリンク): ● Publication site (DOI): 10.1038/s41439-024-00288-7
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 39152105; ● Summary page in Scopus @ Elsevier: 2-s2.0-85201547622

(徳島大学機関リポジトリ: 119580, DOI: 10.1038/s41439-024-00288-7, PubMed: 39152105, Elsevier: Scopus) Shusuke Yagi, Muneyuki Kadota, Ryo Bando, Ryosuke Miyamoto, Hiroyuki Morino, Akiyoshi Kakutani, Yoshiaki Kubo, Takayuki Ise, Rie Ueno, Tomoya Hara, Kenya Kusunose, Koji Yamaguchi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Daiju Fukuda and Masataka Sata :
Pulmonary Arterial Hypertension in Neurofibromatosis Type 1: A Case with a Novel NF1 Gene Mutation,
Internal Medicine, 2024.

(要約): Neurofibromatosis type 1 (NF1) is an autosomal dominant multi-organ disease. The clinical manifestations include not only skin lesions and malignant tumors but also lung complications, including pulmonary arterial hypertension (PAH). However, the association between gene mutations in NF1 and the occurrence of PAH has not yet been elucidated. We herein report a case of isolated PAH in a 67-year-old woman with NF1, presumably caused by a novel heterozygous mutation, c.4485_4486delinsAT (p.Lys1496Ter), in the NF1 gene.
(徳島大学機関リポジトリ): ● Metadata: 119521
(出版サイトへのリンク): ● Publication site (DOI): 10.2169/internalmedicine.3856-24
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38987187; ● Search Scopus @ Elsevier (PMID): 38987187; ● Search Scopus @ Elsevier (DOI): 10.2169/internalmedicine.3856-24

(徳島大学機関リポジトリ: 119521, DOI: 10.2169/internalmedicine.3856-24, PubMed: 38987187) TOMONORI Takahashi, Tetsuzo Wakatsuki, Takayuki Ise and Masataka Sata :
Spontaneous thrombosis of a giant aneurysm complicated with the coronary-to-pulmonary artery fistula: a case report,
European Heart Journal. Case Reports, Vol.8, 2024.

(要約): Background A coronary-to-pulmonary artery fistula (CPAF) with a giant aneurysm is a rare clinical occurrence. The rupture of an aneurysm leads to a fatal outcome, thus prompting the incorporation of prophylactic measures, which have encompassed surgical resections or endovascular embolization procedures. The indications for these treatment strategies are controversial, and little has been elucidated regarding the salient characteristics underpinning the selection of a therapeutic strategy. We report a case of a giant aneurysm associated with CPAFs that was thrombosed before interventional treatment. Case summary A 43-year-old woman, who had previously undergone a right adrenalectomy for primary aldosteronism, was referred for an abnormal heart silhouette on a chest X-ray, which had not been seen three years earlier. Contrast-enhanced computed tomography and coronary angiography (CAG) revealed a giant aneurysm on the anterior aspect of the heart associated with two CPAFs. Because of the risk of rupture of the aneurysm, surgical resection was recommended; however, the patient requested endovascular therapy. On the day of intervention, CAG showed spontaneous occlusion of the feeding vessel to the aneurysm, and the aneurysm showed minimal contrast agent, suggesting spontaneous thrombosis. Because of possible recanalization of the aneurysm, coil embolization was performed, without complications. The patient remained asymptomatic, and the aneurysm was completely embolized at the one-year follow-up. Discussion The case shows that minimally invasive endovascular treatment is feasible instead of surgical resection for giant aneurysms associated with CPAFs, depending on their morphological characteristics. This perspective may offer novel insights into treatment strategies for CPAF.
(キーワード): Coronary-to-pulmonary artery fistulas / Coronary anomalies / Coronary anomalies / Case report
(出版サイトへのリンク): ● Publication site (DOI): 10.1093/ehjcr/ytae227
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1871709542841104768; ● Summary page in Scopus @ Elsevier: 2-s2.0-85192932221

(DOI: 10.1093/ehjcr/ytae227, CiNii: 1871709542841104768, Elsevier: Scopus) N Yamaguchi, Yukina Hirata, Susumu Nishio, TOMONORI Takahashi, Yoshihito Saijo, Muneyuki Kadota, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Masataka Sata and Kenya Kusunose :
Pulmonary Pressure-flow responses to exercise in heart failure treated with angiotensin receptor neprilysin inhibitor.,
International Journal of Cardiology, Vol.400, 131789, 2024.

(要約): The role of the angiotensin receptor neprilysin inhibitor (ARNI) in cardiac function, particularly its impact on pulmonary circulation, remains underexplored. Recent studies have described abnormal mean pulmonary artery pressure (mPAP)-cardiac output (CO) responses as having the potential to assess the disease state. The aim of this study was to assess the effects of ARNI on pulmonary circulation in heart failure. We measured echocardiographic parameters post 6-min walk (6 MW) and compared the changes with baseline and follow-up. Our hypothesis was that pulmonary pressure-flow relationship of the pulmonary circulation obtained by 6 MW stress echocardiography would be improved with treatment. We prospectively enrolled 39 heart failure patients and conducted the 6 MW test indoors. Post-6 MW echocardiography measured echocardiographic variables, and CO was derived from electric cardiometry. Individualized ARNI doses were optimized, with follow-up echocardiographic evaluations after 1 year. Left ventricular (LV) volume were significantly reduced (160.7 ± 49.6 ml vs 136.0 ± 54.3 ml, P < 0.001), and LV ejection fraction was significantly improved (37.6 ± 11.3% vs 44.9 ± 11.5%, P < 0.001). Among the 31 patients who underwent 6 MW stress echocardiographic study at baseline and 1 year later, 6 MW distance increased after treatment (380 m vs 430 m, P = 0.003). The ΔmPAP/ΔCO by 6 MW stress decreased with treatment (6.9 mmHg/L/min vs 2.8 mmHg/L/min, P = 0.002). The left atrial volume index was associated with the response group receiving ARNI treatment for pulmonary circulation. Initiation of ARNI was associated with improvement of left ventricular size and LVEF. Additionally, the 6 MW distance increased and the ΔmPAP/ΔCO was improved to within normal range with treatment.
(徳島大学機関リポジトリ): ● Metadata: 118925
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.ijcard.2024.131789
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38246422; ● Search Scopus @ Elsevier (PMID): 38246422; ● Search Scopus @ Elsevier (DOI): 10.1016/j.ijcard.2024.131789

(徳島大学機関リポジトリ: 118925, DOI: 10.1016/j.ijcard.2024.131789, PubMed: 38246422) Munkhtsetseg Tserensonom, Shusuke Yagi, Takayuki Ise, Yutaka Kawabata, Muneyuki Kadota, Tomoya Hara, Kenya Kusunose, Koji Yamaguchi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Lipoprotein (a) is a risk factor of aortic valve calcification in patients with a risk of atherosclerosis,
The Journal of Medical Investigation : JMI, Vol.70, No.3.4, 450-456, 2023.

(要約): Aortic valve calcification (AVC), which causes aortic stenosis (AS), is more common in elderly persons. Controlling for conventional risk variables did not, however, reduce the incidence of AS. Thus, residual risk factors of AS should be identified. We enrolled 513 patients who underwent coronary angiography with computed tomography because of suspicion of coronary artery disease (CAD) or ruling out of CAD before aortic valve replacement. Calcium volume was calculated with a commercially available application. Conventional and lipid-related risk factors including serum levels of Lp(a) were evaluated for all patients. Calcium volume and Lp(a) levels were significantly higher in patients who underwent aortic valve replacement than in those who did not. A single regression analysis showed that the calcium volume was positively associated with age and the Lp(a) levels and negatively associated with the estimated glomerular filtration rate. No statistical significance was observed for other risk factors, including oxidized low-density lipoprotein, omega-3 fatty acids levels. The multiple regression analysis revealed that age (P<0.001), female sex (P<0.05), Lp(a) (P<0.01), and hemoglobin A1c (P<0.01) were determinants of the calcium volume. The area under the curve in receiver operating characteristic analysis of Lp(a) for implementation of AVR was 0.65 at an Lp(a) cut-off level of 16 mg/dL. In conclusion, the serum Lp(a) level is a potent risk factor of AVC in patients with high risk of atherosclerosis. J. Med. Invest. 70 : 450-456, August, 2023.
(キーワード): Humans / Female / Aged / Aortic Valve / Lipoprotein(a) / Calcium / Aortic Valve Stenosis / Atherosclerosis / Risk Factors / Coronary Artery Disease
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.70.450
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37940531; ● Search Scopus @ Elsevier (PMID): 37940531; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.70.450

(DOI: 10.2152/jmi.70.450, PubMed: 37940531) Yuichiro Okushi, Yoshihito Saijyo, Hirotsugu Yamada, Hiroaki Toba, Robert Zheng, Hiromitsu Seno, TOMONORI Takahashi, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki, Masataka Sata and Kenya Kusunose :
Effectiveness of surveillance by echocardiography for Cancer therapeutics-related cardiac dysfunction of patients with breast Cancer,
Journal of Cardiology, Vol.82, No.6, 467-472, 2023.

(要約): Cancer therapeutics-related cardiac dysfunction (CTRCD) affect the prognosis of patients with breast cancer. Echocardiographic surveillance of patients treated with anti-human epidermal growth factor receptor type 2 (HER2) antibodies has been recommended, but few reports have provided evidence on patients with breast cancer only. We aimed to evaluate the effectiveness of echocardiographic surveillance for breast cancer patients. We identified 250 patients with breast cancer who were treated with anti-HER2 antibodies from July 2007 to September 2021. We divided 48 patients with echocardiographic surveillance every 3 months into the surveillance group and 202 patients without echocardiographic surveillance into the non-surveillance group. In the surveillance group, patients with a considerable reduction in global longitudinal strain of 15 % were considered for the initiation of cardioprotective drugs. The composite outcome of CTRCD and acute heart failure was the study endpoint. The mean age was 59 ± 12 years. During the follow-up period of 15 months (12-17 months), 12 patients reached the endpoint. The surveillance group had significantly lower incidence of the composite outcome (2.1 % vs. 5.5 %, adjusted odds ratio: 0.28, 95 % confidential intervals: 0.09-0.94; p = 0.039) and higher rates of prescriptions of cardioprotective drugs than the non-surveillance group. The incidence of cardiac complications was significantly lower in the surveillance group than the non-surveillance group, which supports the effectiveness of echocardiographic surveillance in patients with breast cancer.
(徳島大学機関リポジトリ): ● Metadata: 118455
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jjcc.2023.07.002
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37481235; ● Summary page in Scopus @ Elsevier: 2-s2.0-85166962366

(徳島大学機関リポジトリ: 118455, DOI: 10.1016/j.jjcc.2023.07.002, PubMed: 37481235, Elsevier: Scopus) U Munkhjargal, Daiju Fukuda, B Ganbaatar, Kumiko Suto, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Koji Yamaguchi, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
A Selective Mineralocorticoid Receptor Blocker, Esaxerenone, Attenuates Vascular Dysfunction in Diabetic C57BL/6 Mice,
Journal of Atherosclerosis and Thrombosis, Vol.30, No.4, 326-334, 2023.

(要約): Pharmacological blockade of mineralocorticoid receptors (MRs) is a potential therapeutic approach to reduce cardiovascular complications since MRs play a crucial role in cardiovascular regulation. Recent studies suggest that MR antagonists affect several extrarenal tissues, including vessel function. We investigated the effect of a novel nonsteroidal selective MR blocker, esaxerenone, on diabetes-induced vascular dysfunction. Diabetes was induced by a single dose of streptozotocin in 8-week-old male C57BL/6 mice. Esaxerenone (3 mg/kg/day) or a vehicle was administered by gavage to diabetic mice for 3 weeks. Metabolic parameters, plasma aldosterone levels, and parameters related to renal function were measured. Endothelium-dependent or -independent vascular responses of the aortic segments were analyzed with acetylcholine or sodium nitroprusside, respectively. Human umbilical vein endothelial cells (HUVECs) were used for the in vitro study. Induction of diabetes elevated plasma aldosterone level (P<0.05) and impaired endothelium-dependent vascular relaxation (P<0.05). The administration of esaxerenone ameliorated the endothelial dysfunction (P<0.01) without the alteration of metabolic parameters, blood pressure, and renal function. Esaxerenone improved the eNOS phosphorylation in the aorta obtained from diabetic mice (P<0.05) compared with that in the vehicle-treated group. Furthermore, a major MR agonist, aldosterone, decreased eNOS phosphorylation and increased eNOS phosphorylation in HUVECs, which recovered with esaxerenone. Esaxerenone ameliorated the endothelium-dependent vascular relaxation caused by aldosterone in the aortic segments obtained from C57BL/6 mice (P<0.001). Esaxerenone attenuates the development of diabetes-induced endothelial dysfunction in mice. These results suggest that esaxerenone has potential vascular protective effects in individuals with diabetes.
(徳島大学機関リポジトリ): ● Metadata: 118690
(出版サイトへのリンク): ● Publication site (DOI): 10.5551/jat.63382
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35732424; ● Search Scopus @ Elsevier (PMID): 35732424; ● Search Scopus @ Elsevier (DOI): 10.5551/jat.63382

(徳島大学機関リポジトリ: 118690, DOI: 10.5551/jat.63382, PubMed: 35732424) TOMONORI Takahashi, Kenya Kusunose, S Hayashi, Robert Zheng, Natsumi Yamaguchi, Sae Morita, Yukina Hirata, Susumu Nishio, Yoshihito Saijyo, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Isoproterenol loading transesophageal echocardiography in atrial fibrillation,
The International Journal of Cardiovascular Imaging, Vol.39, No.3, 511-518, 2023.

(要約): In patients with sludge or severe spontaneous echo contrast (SEC) in the left atrial appendage (LAA), cases with isoproterenol loading transesophageal echocardiography (ISP-TEE) have been reported to identify the presence of thrombus in the LAA. This study aimed to assess the validity and hemodynamic changes of ISP-TEE in the LAA. We prospectively enrolled patients with atrial fibrillation (AF) who underwent ISP-TEE. The degree of sludge/SEC was categorized as being either absent (grade 0), mild SEC (grade 1), moderate SEC (grade 2), severe SEC or sludge (grade 3). The hemodynamic evaluation was performed by measuring LAA flow velocity, LAA tissue Doppler imaging (LAA-TDI) velocity, and pulmonary vein systolic forward flow velocity (PVS). In total, 35 patients (mean age 71 ± 7 years; 71% male) underwent ISP-TEE. Among 35 patients, 30 patients had grade 3 or 2 SEC, 5 patients had grade 1 SEC. After ISP loading, 23 patients (66% of all patients) showed improved sludge/SEC and one patient was diagnosed with thrombus in the LAA. There were 25 patients with grade 1 SEC, or no SEC (classified as Group1), 10 patients had residual sludge or grade 2 to 3 SEC (classified as Group2) after ISP administration. LAA flow, LAA-TDI, and PVS velocities were significantly higher in group 1 than in group 2 after ISP administration. There was no complication during the examination and after 24 h and 3 months. ISP infusion may be a potential tool to recognize LAA thrombus under the sludge/SEC during TEE in AF.
(キーワード): Humans / Male / Middle Aged / Aged / Female / Atrial Fibrillation / Echocardiography, Transesophageal / Isoproterenol / Sewage / Atrial Appendage / Predictive Value of Tests / Thrombosis
(徳島大学機関リポジトリ): ● Metadata: 118275
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s10554-022-02749-y
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36357528; ● Search Scopus @ Elsevier (PMID): 36357528; ● Search Scopus @ Elsevier (DOI): 10.1007/s10554-022-02749-y

(徳島大学機関リポジトリ: 118275, DOI: 10.1007/s10554-022-02749-y, PubMed: 36357528) Kenya Kusunose, Yuichiro Okushi, Y Okayama, Robert Zheng, M Nakai, Y Sumita, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Benefits of guideline-directed medical therapy to loop diuretics in management of heart failure,
The Journal of Medical Investigation : JMI, Vol.70, No.1.2, 41-53, 2023.

(キーワード): heart failure / angiotensin-converting enzyme inhibitor / angiotensin receptor blocker / β-blockers / mineralocorticoid receptor antagonists
(徳島大学機関リポジトリ): ● Metadata: 118306
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.70.41
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37164742; ● CiNii @ 国立情報学研究所 (CRID): 1390296055446303872; ● Search Scopus @ Elsevier (PMID): 37164742; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.70.41

(徳島大学機関リポジトリ: 118306, DOI: 10.2152/jmi.70.41, PubMed: 37164742, CiNii: 1390296055446303872) Yutaka Kawabata, Tetsuzo Wakatsuki, Koji Yamaguchi, Daiju Fukuda, Hiroyuki Ito, Tomomi Matsuura, Kenya Kusunose, Takayuki Ise, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Y Tsuruo and Masataka Sata :
Association of Microluminal Structures Assessed by Optical Coherence Tomography With Local Inflammation in Adjacent Epicardial Adipose Tissue and Coronary Plaque Characteristics in Fresh Cadavers,
Circulation Journal, Vol.87, No.2, 329-335, 2023.

(要約): Coronary intraplaque microluminal structures (MS) are associated with plaque vulnerability, and the inward progression of vascular inflammation from the adventitia towards the media and intima has also been demonstrated. Therefore, in the present study we investigated the relationships among MS, local inflammation in adjacent epicardial adipose tissue (EAT), and coronary plaque characteristics.Methods and Results: Optical coherence tomography (OCT) revealed MS in the left anterior descending coronary artery in 10 fresh cadaveric hearts. We sampled 30 lesions and subdivided them based on the presence of MS: MS (+) group (n=19) and MS (-) group (n=11). We measured inflammatory molecule levels in the adjacent EAT and percentage lipid volume assessed by integrated backscatter intravascular ultrasound in each lesion. The expression levels of vascular endothelial growth factor B and C-C motif chemokine ligand 2 were significantly higher in the MS (+) group than in the MS (-) group (0.9±0.7 vs. 0.2±0.2 arbitrary units (AU), P=0.04 and 1.5±0.5 vs. 0.6±0.7 AU, P=0.02, respectively). Percentage lipid volume was significantly higher in the MS (+) group than in the MS (-) group (38.7±16.5 vs. 23.7±10.9%, P=0.03). Intraplaque MS observed on OCT were associated with lipid-rich plaques and local inflammation in the adjacent EAT. Collectively, these results suggest that local inflammation in the EAT is associated with coronary plaque vulnerability via MS.
(徳島大学機関リポジトリ): ● Metadata: 117602
(出版サイトへのリンク): ● Publication site (DOI): 10.1253/circj.CJ-22-0299
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36244741; ● Search Scopus @ Elsevier (PMID): 36244741; ● Search Scopus @ Elsevier (DOI): 10.1253/circj.CJ-22-0299

(徳島大学機関リポジトリ: 117602, DOI: 10.1253/circj.CJ-22-0299, PubMed: 36244741) Tomonori Takahashi, Kenya Kusunose, Robert Zheng, Natsumi Yamaguchi, Yukina Hirata, Susumu Nishio, Yoshihito Saijyo, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Association between cardiovascular risk factors and left ventricular strain distribution in patients without previous cardiovascular disease,
Journal of Echocardiography, Vol.20, No.4, 208-215, 2022.

(要約): Some cardiovascular (CV) risk factors, such as hypertension and diabetes mellitus, have been reported to reduce left ventricular (LV) longitudinal strain (LS) even in patients with preserved LV ejection fraction. We hypothesized that multiple CV risk factors might cause changes in myocardial strain. Our study aimed to assess the association between multiple CV risk factors and strain in patients without previous CV disease (CVD). We retrospectively evaluated 137 patients without CVD, who underwent echocardiography at our institution between May 2017 and February 2020. They were divided into four groups based on the number of risk factors (group 0: no risk factor, group 1: one risk factor, group 2: two risk factors, and groups 3: three or four risk factors). Risk factors were hypertension, dyslipidemia, diabetes mellitus, and chronic kidney disease. Absolute values of global LS (GLS) and relative apical LS ratio (RALSR) defined using the equation: average apical LS/(average basal LS + average mid LS) and was used as a marker of strain distribution. Out of 137 patients, group 0 had 35 patients, group 1 had 35 patients, group 2 had 32 patients, and group 3 had 35 patients. GLS was 22.4 ± 2.0%, 21.7 ± 2.1%, 21.3 ± 1.8%, 20.7 ± 2.2%, and RALSR was 0.64 ± 0.06, 0.66 ± 0.06, 0.68 ± 0.08, 0.69 ± 0.07 in groups 0-3, respectively. The one-way ANOVA detected significant differences between groups in GLS (p = 0.005) and RALSR (p = 0.037), respectively. Group 3 had a significantly lower GLS and higher RALSR than group 0 (p < 0.05). In patients without previous CVD, LS decreased especially from the basal segment as the number of cardiovascular risks increased. The segmental LS may be markers of occult LV dysfunction in patients with CV risk factors.
(キーワード): Humans / Cardiovascular Diseases / Retrospective Studies / Risk Factors / Stroke Volume / Ventricular Function, Left / Ventricular Dysfunction, Left / Heart Disease Risk Factors / Hypertension
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s12574-022-00576-7
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35562627; ● Search Scopus @ Elsevier (PMID): 35562627; ● Search Scopus @ Elsevier (DOI): 10.1007/s12574-022-00576-7

(DOI: 10.1007/s12574-022-00576-7, PubMed: 35562627) O Bavuu, Daiju Fukuda, B Ganbaatar, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Koji Yamaguchi, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Esaxerenone, a selective mineralocorticoid receptor blocker, improves insulin sensitivity in mice consuming high-fat diet.,
European Journal of Pharmacology, 175190, 2022.

(要約): Esaxerenone is a novel, non-steroidal selective mineralocorticoid receptor (Csige et al.) blocker. MR activation plays a crucial role in the development of cardiovascular and metabolic diseases. In this study, we investigated the effects of esaxerenone on various metabolic parameters in mice. Esaxerenone (3 mg/kg/day) was orally administered to high-fat diet (HFD)-fed male C57BL/6 mice. Mice fed a normal diet (ND) served as controls. Glucose and insulin tolerance, plasma lipid levels, and transaminase levels were assessed as metabolic parameters. Macrophage accumulation in the adipose tissue was evaluated using histological analysis. 3T3-L1 adipocytes, HepG2 cells, and C2C12 myotubes were used for in vitro experiments. Gene expression and insulin signaling were examined using quantitative RT-PCR and western blotting, respectively. HFD successfully induced insulin resistance compared with that in ND. Esaxerenone ameliorated insulin resistance (P < 0.05) without altering other metabolic parameters, such as the lipid profile. Esaxerenone administration tended to decrease plasma transaminase levels compared with those in the non-treated group. In the adipose tissue, esaxerenone decreased macrophage accumulation (P < 0.05) and increased the expression levels of adiponectin and PPARγ. Aldosterone significantly decreased the expression levels of PPARγ and adiponectin in 3T3-L1 adipocytes. Furthermore, aldosterone attenuated insulin-induced Akt phosphorylation in 3T3-L1 adipocytes, HepG2 cells, and C2C12 myotubes in a dose-dependent manner (P < 0.01). These effects were ameliorated by pretreatment with esaxerenone. Esaxerenone ameliorated insulin resistance in HFD-fed mice. Reduction of inflammation and improvement in insulin signaling may underlie the beneficial effects of esaxerenone.
(徳島大学機関リポジトリ): ● Metadata: 117375
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.ejphar.2022.175190
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35961594; ● Search Scopus @ Elsevier (PMID): 35961594; ● Search Scopus @ Elsevier (DOI): 10.1016/j.ejphar.2022.175190

(徳島大学機関リポジトリ: 117375, DOI: 10.1016/j.ejphar.2022.175190, PubMed: 35961594) Kenya Kusunose, Hirotsugu Yamada, Y Saijo, Susumu Nishio, Yukina Hirata, Takayuki Ise, Koji Yamaguchi, Daiju Fukuda, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Clinical course and decision-making in heart failure by preload stress echocardiography: a preliminary study,
ESC Heart Failure, Vol.9, No.6, 4020-4029, 2022.

(要約): Abnormal left ventricular diastolic response to preload stress can be an early marker of heart failure (HF). The aim of this study was to assess clinical course in patients with HF with preserved ejection fraction (HFpEF) who underwent preload stress echocardiography. In the subgroup analysis, we assessed the prognosis of patients with unstable signs during preload stress classified by treatment strategies. We prospectively conducted preload stress echocardiographic studies between January 2006 and December 2013 in 211 patients with HFpEF. Fifty-eight patients had abnormal diastolic reserve during preload stress (unstable impaired relaxation: unstable IR). Of 58 patients with unstable IR, 19 patients were assigned to additional therapy by increased or additional therapy and 39 patients were assigned to standard therapy. Composite outcomes were prespecified as the primary endpoint of death and hospitalization for deteriorating HF. During a median period of 6.9 years, 19 patients (33%) reached the composite outcome. Unstable group with standard therapy had significantly shorter event-free survival than stable group. Patients with uptitration of therapy had longer event-free survival than those with standard therapy group after adjustment of laboratory data (hazard ratio, 0.20, 95% confidence interval, 0.05-0.90; P = 0.036); the 10 year event-free survival in patients with and without uptitration of therapy was 93% and 51%, respectively (P = 0.023). Patients with unstable sign had significantly shorter event-free survival than patients with stable sign. After additional therapy, the prognosis of patients with unstable signs improved. This technique may impact decision-making for improving their prognosis.
(徳島大学機関リポジトリ): ● Metadata: 118008
(出版サイトへのリンク): ● Publication site (DOI): 10.1002/ehf2.14127
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36017722; ● Search Scopus @ Elsevier (PMID): 36017722; ● Search Scopus @ Elsevier (DOI): 10.1002/ehf2.14127

(徳島大学機関リポジトリ: 118008, DOI: 10.1002/ehf2.14127, PubMed: 36017722) Koji Yamaguchi, Tetsuzo Wakatsuki, Tomomi Matsuura, Kazuhisa Matsumoto, Yutaka Kawabata, Muneyuki Kadota, Kenya Kusunose, Takayuki Ise, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Drug-coated balloon angioplasty for severe pulmonary vein stenosis resulting from cryoballoon ablation for atrial fibrillation,
Journal of Cardiology Cases, Vol.26, 35-38, 2022.

(徳島大学機関リポジトリ): ● Metadata: 117234
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jccase.2022.02.009
(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-85127324683

(徳島大学機関リポジトリ: 117234, DOI: 10.1016/j.jccase.2022.02.009, Elsevier: Scopus) Y Okushi, Kenya Kusunose, M Nakai, Y Sumita, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Comparison of Direct Oral Anticoagulants for Acute Hospital Mortality in Venous Thromboembolism,
American Journal of Cardiovascular Drugs, Vol.22, No.4, 407-416, 2022.

(要約): The choice of direct oral anticoagulants (DOACs) for venous thromboembolism (VTE) is at the physician's discretion; however, it is useful to know the differences in the clinical data of DOACs to help physicians choose. We aimed to compare the mortality associated with the use of rivaroxaban, edoxaban, and apixaban in clinical practice. We identified 38,245 patients with first hospitalization for VTE from the Diagnosis Procedure Combination database in the Japanese Registry of All Cardiac and Vascular Datasets (JROAD-DPC). We classified patients into three groups by DOAC (rivaroxaban and edoxaban group, rivaroxaban and apixaban group, and edoxaban and apixaban group) and compared the in-hospital mortality and bleeding risk by propensity score (PS) matching in each group. After PS matching, patients with rivaroxaban use had significantly lower total in-hospital mortality (1.2% vs. 2.1%; odds ratio [OR] 0.55, p = 0.012) and in-hospital mortality within 21 days (0.4% vs. 1.0%; OR 0.41, p = 0.020) and 28 days (0.7% vs. 1.3%; OR 0.53, p = 0.042) than patients with apixaban use. In the subanalysis, significant differences were only observed in patients younger than 80 years of age, patients with pulmonary embolism, and patients without heart failure. There was no significant difference in in-hospital mortality in the other groups and in the rate of bleeding events among the three groups. On PS-matched analysis, there was a difference in in-hospital mortality, especially in the rivaroxaban and apixaban group. Identifying the clinical characteristics of patients associated with each DOAC, as well as prognosis, will be useful in determining treatment strategies for VTE.
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s40256-021-00514-5
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34927214; ● Search Scopus @ Elsevier (PMID): 34927214; ● Search Scopus @ Elsevier (DOI): 10.1007/s40256-021-00514-5

(DOI: 10.1007/s40256-021-00514-5, PubMed: 34927214) Kazuhisa Matsumoto, Takeshi Tobiume, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Tetsuzo Wakatsuki, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Evaluation of the input site and characteristics of the antegrade fast pathway based on three-dimensional bi-atrial stimulus-ventricle mapping,
Journal of Interventional Cardiac Electrophysiology, Vol.63, No.2, 417-424, 2022.

(要約): Previous studies examined the right atrial (RA) input site of the antegrade fast pathway (AFp) (AFpI). However, the left atrial (LA) input to the atrioventricular (AV) node has not been extensively evaluated. In this study, we created three-dimensional (3-D) bi-atrial stimulus-ventricle (St-V) maps and analyzed the input site and characteristics of the AFp in both the RA and LA. Forty-four patients diagnosed with atrial fibrillation or WPW syndrome were included in this study. Three-dimensional bi-atrial St-V mapping was performed using an electroanatomical mapping system. Sites exhibiting the minimal St-V interval (MinSt-V) were defined as AFpIs and were classified into seven segments, four in the RA (F, S, M, and I) and three in the LA (M1, M2, and M3). By combining the MinSt-V in the RA and LA, the AFpIs were classified into three types: RA, LA, and bi-atrial (BA) types. The clinical and electrophysiological characteristics were compared. AFpIs were most frequently observed at site S in the RA (34%) and M2 in the LA (50%), and the BA type was the most common (57%). AFpIs in the LA were recognized in 75% of the patients. There were no clinical or electrophysiological indicators for predicting AFpI sites. Three-dimensional bi-atrial St-V maps could classify AFpIs in both the RA and LA. AFpIs in the LA were frequently recognized. There were no significant clinical or electrophysiological indicators for predicting AFpI sites, and 3-D bi-atrial St-V mapping was the only method to reveal the precise AFp input site.
(徳島大学機関リポジトリ): ● Metadata: 116382
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s10840-021-01026-7
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34231099; ● Search Scopus @ Elsevier (PMID): 34231099; ● Search Scopus @ Elsevier (DOI): 10.1007/s10840-021-01026-7

(徳島大学機関リポジトリ: 116382, DOI: 10.1007/s10840-021-01026-7, PubMed: 34231099) Shusuke Yagi, Daiju Fukuda, Takayuki Ise, Koji Yamaguchi, Kenya Kusunose, Muneyuki Kadota, Yutaka Kawabata, Tomomi Matsuura, Tomohiro Soga, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Shinji Kawahito and Masataka Sata :
Clinical clerkship students' preferences and satisfaction regarding online lectures during the COVID-19 pandemic,
BMC Medical Education, Vol.22, No.1, 43, 2022.

(要約): The COVID-19 pandemic has caused an unprecedented disruption in medical education. Students and lecturers had to adapt to online education. The current study aimed to investigate the level of satisfaction and future preference for online lectures among clinical clerkship students and elucidated the factors that affect these outcomes. We selected a sample of 114 medical students undergoing clinical clerkship during the COVID-19 pandemic. We conducted onsite lectures before the pandemic and online lectures after the outbreak. A survey was conducted, and the sample included students and 17 lecturers. The average scores of total satisfaction and future preference related to online lectures were computed. Students' scores on total satisfaction with online lectures and their future preference were higher than those for onsite lectures. Scores on the ease of debating dimension were low and those on accessibility of lectures in online lectures were higher than those in onsite lectures. There was no difference between the two groups in the scores on the comprehensibility and ease of asking questions dimensions. Results of the multiple regression analysis revealed that accessibility determined total satisfaction, and future preference was determined by comprehensibility as well as accessibility. Contrary to students' future preferences, lecturers favored onsite lectures to online ones. Online lectures are an acceptable mode of teaching during the COVID-19 pandemic for students undergoing clinical clerkship. Online lectures are expected to become more pervasive to avoid the spread of COVID-19.
(キーワード): COVID-19 / Clinical Clerkship / Humans / Pandemics / Personal Satisfaction / SARS-CoV-2 / Students, Medical
(徳島大学機関リポジトリ): ● Metadata: 116989
(出版サイトへのリンク): ● Publication site (DOI): 10.1186/s12909-021-03096-7
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35042505; ● Summary page in Scopus @ Elsevier: 2-s2.0-85123015852

(徳島大学機関リポジトリ: 116989, DOI: 10.1186/s12909-021-03096-7, PubMed: 35042505, Elsevier: Scopus) Nao Ishii, Kenya Kusunose, A Shono, K Matsumoto, Susumu Nishio, Natsumi Yamaguchi, Yukina Hirata, Tomomi Matsuura, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Effects of Radiofrequency Catheter Ablation on Cardiac Reserve Using Preload Stress Echocardiography in Paroxysmal and Persistent Atrial Fibrillation,
The American Journal of Cardiology, Vol.168, 71-77, 2022.

(要約): The effects of catheter ablation on exercise tolerance and quality of life in patients with atrial fibrillation (AF) have been reported. We assessed cardiac function in more detail using the leg positive pressure (LPP) technique and found that contractile reserve is particularly important in relation to exercise tolerance and prognosis. In this study, we used the LPP technique to examine changes in contractile reserve immediately after ablation and 6 months later. We prospectively enrolled patients who underwent catheter ablation for AF at 2 institutes. We performed LPP stress echocardiography 2 to 3 days after (FU-1) and 6 months after (FU-2) ablation to examine changes in cardiac function indexes. The primary end point was improvement in contractile reserve. Ultimately, 109 patients (mean age 67.4 ± 9.6 years; 70% men) underwent 2 sessions of LPP stress echocardiography. The median CHADS-VAS score was 2 (interquartile range 13). From FU-1 to FU-2, the change in the stroke volume index after the LPP maneuver increased in patients with paroxysmal and persistent AF with low CHADS-VAS scores (both p <0.05). Regardless of AF subtype, contractile reserve at FU-2 improved in patients with low CHADS-VAS scores compared with that at FU-1. In contrast, patients with high CHADS-VAS scores had no change. In conclusion, patients with AF with a low CHADS-VAS score had improved contractile reserve after ablation, whereas patients with high scores did not show any improvement. Aggressive interventions in patients with high scores may lead to better management after catheter ablation.
(キーワード): Aged / Atrial Fibrillation / Catheter Ablation / Echocardiography, Stress / Female / Humans / Male / Middle Aged / Predictive Value of Tests / Quality of Life / Risk Assessment / Risk Factors / Treatment Outcome
(徳島大学機関リポジトリ): ● Metadata: 116987
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.amjcard.2021.12.026
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35063270; ● Search Scopus @ Elsevier (PMID): 35063270; ● Search Scopus @ Elsevier (DOI): 10.1016/j.amjcard.2021.12.026

(徳島大学機関リポジトリ: 116987, DOI: 10.1016/j.amjcard.2021.12.026, PubMed: 35063270) Kenya Kusunose, Miharu Arase, Robert Zheng, Yukina Hirata, Susumu Nishio, Takayuki Ise, Koji Yamaguchi, Daiju Fukuda, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Clinical Utility of Overlap Time for Incomplete Relaxation to Predict Cardiac Events in Heart Failure: Incomplete relaxation in heart failure,
Journal of Cardiac Failure, Vol.27, No.11, 1222-1230, 2021.

(要約): The overlap time of transmitral flow can be a novel marker of subclinical left ventricular (LV) dysfunction for predicting adverse events in heart failure (HF). We aimed to 1) investigate the role of overlap time of E-A wave in association with clinical parameters, and 2) evaluate whether the overlap time could add prognostic information with respect to other conventional clinical prognosticators in HF. We prospectively evaluated 153 patients hospitalized with HF (mean age 68±15 years; 63% male). The primary endpoint was readmission following HF and cardiac death. During a median period of 25 months, 43 patients were either readmitted or died. Overlap time appeared to be associated with worse outcomes. After adjustment for readmission score and ratio of diastolic filling period and cardiac cycle length in a Cox proportional-hazards model, overlap time was associated with event free survival, independent of elevated left atrial pressure (LAP) based on guidelines. When overlap time was added to the model based on clinical variables and elevated LAP, the C-statistic significantly improves from 0.70 (95% CI: 0.63-0.77) to 0.77 (95% CI: 0.69-0.83, compared P=0.035). This preliminary study suggested that prolonged overlap time may have potential for predicting readmission and cardiac mortality risk assessment in HF.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.cardfail.2021.05.018
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34129950; ● Search Scopus @ Elsevier (PMID): 34129950; ● Search Scopus @ Elsevier (DOI): 10.1016/j.cardfail.2021.05.018

(DOI: 10.1016/j.cardfail.2021.05.018, PubMed: 34129950) Robert Zheng, Kenya Kusunose, Y Okushi, Y Okayama, M Nakai, Y Sumita, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Impact of cancer on short-term in-hospital mortality after primary acute myocardial infarction,
Open Heart, Vol.8, No.2, e00186, 2021.

(徳島大学機関リポジトリ): ● Metadata: 116972
(出版サイトへのリンク): ● Publication site (DOI): 10.1136/openhrt-2021-001860
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34810277; ● Summary page in Scopus @ Elsevier: 2-s2.0-85120377378

(徳島大学機関リポジトリ: 116972, DOI: 10.1136/openhrt-2021-001860, PubMed: 34810277, Elsevier: Scopus) Kenya Kusunose, Hironori Takahashi, Susumu Nishio, Yukina Hirata, Robert Zheng, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Kenji Shimada, Yasuhisa Kanematsu, Yasushi Takagi and Masataka Sata :
Predictive value of left atrial function for latent paroxysmal atrial fibrillation as the cause of embolic stroke of undetermined source,
Journal of Cardiology, Vol.78, No.5, 355-361, 2021.

(要約): In patients with embolic stroke of undetermined source (ESUS), paroxysmal atrial fibrillation (AF) is often diagnosed, however, the risk of paroxysmal AF in ESUS has not been well described. Several studies have suggested a linkage between left atrial (LA) functional parameters and risk of AF in stroke patients. The aim of this study was to assess the role of LA functional parameters as predictors of latent paroxysmal AF in ESUS on admission. Between January 2015 and December 2019, consecutive stroke patients with suspected ESUS at admission were prospectively included in this study. They were under hospital electrocardiographic monitoring for detection of new-onset AF. Various echocardiographic parameters including left atrial strain were assessed for association with new-onset AF. We gathered 1082 consecutive patients with ischemic stroke. After exclusions, 121 patients with suspected ESUS at admission formed the study cohort. New-onset AF was detected in 46 (38%) patients during hospital electrocardiographic monitoring (median follow-up: 18 days). LA pump and reservoir strains were significantly and independently associated with new-onset AF. Receiver operating characteristic analysis for the association with new-onset AF showed that the areas under the curve (AUCs) of clinical parameters plus one of each strain (LA pump strain: AUC: 0.86±0.04 and LA reservoir strain: AUC: 0.76±0.05) models were significantly better than plus LA volume index (AUC: 0.68±0.04, compared p-values <0.05). LA strain was significantly associated with new development of AF. Patients with impaired LA function at admission should be carefully monitored to find AF.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jjcc.2021.05.005
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34119401; ● Search Scopus @ Elsevier (PMID): 34119401; ● Search Scopus @ Elsevier (DOI): 10.1016/j.jjcc.2021.05.005

(DOI: 10.1016/j.jjcc.2021.05.005, PubMed: 34119401) Kenya Kusunose, Yuichiro Okushi, Yoshihiro Okayama, Robert Zheng, Michikazu Nakai, Yoko Sumita, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Use of Echocardiography and Heart Failure In-Hospital Mortality from Registry Data in Japan.,
Journal of Cardiovascular Development and Disease, Vol.8, No.10, 124, 2021.

(要約): Echocardiography requires a high degree of skill on the part of the examiner, and the skill may be more improved in larger volume centers. This study investigated trends and outcomes associated with the use and volume of echocardiographic exams from a real-world registry database of heart failure (HF) hospitalizations. This study was based on the Diagnosis Procedure Combination database in the Japanese Registry of All Cardiac and Vascular Datasets (JROAD-DPC). A first analysis was performed to assess the trend of echocardiographic examinations between 2012 and 2016. A secondary analysis was performed to assess whether echocardiographic use was associated with in-hospital mortality in 2015. During this period, the use of echocardiography grew at an average annual rate of 6%. Patients with echocardiography had declining rates of hospital mortality, and these trends were associated with high hospitalization costs. In the 2015 sample, a total of 52,832 echocardiograms were examined, corresponding to 65.6% of all HF hospital admissions for that year. We found that the use and volume of echocardiography exams were associated with significantly lower odds of all-cause hospital mortality in heart failure (adjusted odds ratio (OR): 0.48 for use of echocardiography and 0.78 for the third tertile; both < 0.001). The use of echocardiography was associated with decreased odds of hospital mortality in HF. The volumes of echocardiographic examinations were also associated with hospital mortality.
(徳島大学機関リポジトリ): ● Metadata: 117323
(出版サイトへのリンク): ● Publication site (DOI): 10.3390/jcdd8100124
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34677193; ● Summary page in Scopus @ Elsevier: 2-s2.0-85116636823

(徳島大学機関リポジトリ: 117323, DOI: 10.3390/jcdd8100124, PubMed: 34677193, Elsevier: Scopus) Shusuke Yagi, T Takahashi, K Murakami, M Azuma, M Sugano, R Miyamoto, M Niki, Hirotsugu Yamada, Yutaka Kawabata, Tani Akihiro, Daiju Fukuda, Muneyuki Kadota, Takayuki Ise, Kenya Kusunose, Takeshi Tobiume, Tomomi Matsuura, Koji Yamaguchi, Takeshi Soeki, Tetsuzo Wakatsuki, H Hata and Masataka Sata :
Infective Endocarditis from Furuncle with Meningitis Complication Caused by Methicillin-resistant Staphylococcus aureus,
Internal Medicine, Vol.60, No.20, 3251-3255, 2021.

(徳島大学機関リポジトリ): ● Metadata: 118014
(出版サイトへのリンク): ● Publication site (DOI): 10.2169/internalmedicine.6902-20
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33867390; ● Search Scopus @ Elsevier (PMID): 33867390; ● Search Scopus @ Elsevier (DOI): 10.2169/internalmedicine.6902-20

(徳島大学機関リポジトリ: 118014, DOI: 10.2169/internalmedicine.6902-20, PubMed: 33867390) Yuta Torii, Kenya Kusunose, Yukina Hirata, Susumu Nishio, Takayuki Ise, Koji Yamaguchi, Daiju Fukuda, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Left Atrial Strain Associated with Functional Recovery in Patients Receiving Optimal Treatment for Heart Failure,
Journal of the American Society of Echocardiography, Vol.34, No.9, 966-975, 2021.

(要約): Heart failure with recovered ejection fraction (HFrecEF) has been reported in several previous studies to have a better prognosis than heart failure with reduced ejection fraction (HFrEF). However, the factors associated with HFrecEF have not been identified. The aim of this study was to test the hypothesis that left atrial (LA) strain could help identify patients with recovered ejection fraction (EF) among those with heart failure (HF) with low EF on admission. One hundred consecutive patients hospitalized for the first time for new-onset HF were enrolled. Patients were clinically diagnosed with HFrEF on admission (left ventricular EF < 40%) and received optimal treatment for HF. Twenty-eight patients improved to HFrecEF during 6 months of follow-up. Regarding clinical background, there were significantly more women and a lower rate of atrial fibrillation in the HFrecEF group than in the HFrEF group. In a multivariate logistic regression analysis, LA strain was an independent predictor of HFrecEF, even after adjustment for gender and left ventricular EF (odds ratio: 4.06; 95% CI: 2.04-8.07; P < .001). A cutoff value of 10.8% for LA strain showed high sensitivity (96%) and specificity (82%) in identifying HFrecEF in patients with HF presenting with low EF on admission. During a follow-up period of 24 ± 13 months, 31 patients (31%) had cardiovascular death or readmission for HF. Patients with reduced LA strain (<10.8%) had significantly shorter event-free survival than those with preserved LA strain (P = .02). LA strain is a useful indicator for predicting HFrecEF and should be considered as a routine measurement in patients with HFrEF on admission.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.echo.2021.03.016
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33852960; ● Search Scopus @ Elsevier (PMID): 33852960; ● Search Scopus @ Elsevier (DOI): 10.1016/j.echo.2021.03.016

(DOI: 10.1016/j.echo.2021.03.016, PubMed: 33852960) Tomomi Matsuura, Takeshi Soeki, Daiju Fukuda, Etsuko Uematsu, Takeshi Tobiume, Tomoya Hara, Kenya Kusunose, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Hirotsugu Yamada, Tetsuzo Wakatsuki and Masataka Sata :
Activated Factor X Signaling Pathway via Protease-Activated Receptor 2 Is a Novel Therapeutic Target for Preventing Atrial Fibrillation,
Circulation Journal, Vol.85, No.8, 1383-1391, 2021.

(要約): Activated factor X (FXa), which contributes to chronic inflammation via protease-activated receptor 2 (PAR2), might play an important role in atrial fibrillation (AF) arrhythmogenesis. This study aimed to assess whether PAR2 signaling contributes to AF arrhythmogenesis and whether rivaroxaban ameliorates atrial inflammation and prevents AF.Methods and Results:In Study 1, PAR2 deficient (PAR2-/-) and wild-type mice were infused with angiotensin II (Ang II) or a vehicle via an osmotic minipump for 2 weeks. In Study 2, spontaneously hypertensive rats (SHRs) were treated with rivaroxaban, warfarin, or vehicle for 2 weeks after 8 h of right atrial rapid pacing. The AF inducibility and atrial remodeling in both studies were examined. Ang II-treated PAR2-/- mice had a lower incidence of AF and less mRNA expression of collagen1 and collagen3 in the atrium compared to wild-type mice treated with Ang II. Rivaroxaban significantly reduced AF inducibility compared with warfarin or vehicle. In SHRs treated with a vehicle, rapid atrial pacing promoted gene expression of inflammatory and fibrosis-related biomarkers in the atrium. Rivaroxaban, but not warfarin, significantly reduced expression levels of these genes. The FXa-PAR2 signaling pathway might contribute to AF arrhythmogenesis associated with atrial inflammation. A direct FXa inhibitor, rivaroxaban, could prevent atrial inflammation and reduce AF inducibility, probably by inhibiting the pro-inflammatory activation.
(徳島大学機関リポジトリ): ● Metadata: 116065
(出版サイトへのリンク): ● Publication site (DOI): 10.1253/circj.CJ-20-1006
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33746155; ● Summary page in Scopus @ Elsevier: 2-s2.0-85111576585

(徳島大学機関リポジトリ: 116065, DOI: 10.1253/circj.CJ-20-1006, PubMed: 33746155, Elsevier: Scopus) Pham Tran Phuong, Daiju Fukuda, Sachiko Nishimoto, JR Kim-Kaneyama, XF Lei, Yutaka Takahashi, Tomohito Sato, Kimie Tanaka, Kumiko Suto, Yutaka Kawabata, Koji Yamaguchi, Shusuke Yagi, Kenya Kusunose, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Kenji Shimada, Yasuhisa Kanematsu, Yasushi Takagi, Michio Shimabukuro, Mitsutoshi Setou, Glen N Barber and Masataka Sata :
STING, a cytosolic DNA sensor, plays a critical role in atherogenesis: a link between innate immunity and chronic inflammation caused by lifestyle-related diseases,
European Heart Journal, Vol.42, No.42, 4336-4348, 2021.

(要約): Lifestyle-related diseases promote atherosclerosis, a chronic inflammatory disease; however, the molecular mechanism remains largely unknown. Endogenous DNA fragments released under over-nutrient condition provoke sterile inflammation through the recognition by DNA sensors. Here, we investigated the role of stimulator of interferon genes (STING), a cytosolic DNA sensor, in atherogenesis. Apolipoprotein E-deficient (Apoe-/-) mice fed a western-type diet (WTD), a hypercholesterolaemic mouse model, showed higher STING expression and markers for DNA damage such as γH2AX, p53, and single-stranded DNA (ssDNA) accumulation in macrophages in the aorta compared with wild-type (WT) mice. The level of cGAMP, a STING agonist, in the aorta was higher in Apoe-/- mice. Genetic deletion of Sting in Apoe-/- mice reduced atherosclerotic lesions in the aortic arch, lipid, and macrophage accumulation in plaques, and inflammatory molecule expression in the aorta compared with the control. Pharmacological blockade of STING using a specific inhibitor, C-176, ameliorated atherogenesis in Apoe-/- mice. In contrast, bone marrow-specific STING expression in Apoe-/- mice stimulated atherogenesis. Expression or deletion of STING did not affect metabolic parameters and blood pressure. In vitro studies revealed that STING activation by cGAMP or mitochondrial DNA accelerated inflammatory molecule expression (e.g. TNF-α or IFN-β) in mouse and human macrophages. Activation of nuclear factor-κB and TANK binding kinase 1 was involved in STING-associated vascular inflammation and macrophage activation. Furthermore, human atherosclerotic lesions in the carotid arteries expressed STING and cGAMP. Stimulator of interferon genes stimulates pro-inflammatory activation of macrophages, leading to the development of atherosclerosis. Stimulator of interferon genes signalling may serve as a potential therapeutic target for atherosclerosis.
(出版サイトへのリンク): ● Publication site (DOI): 10.1093/eurheartj/ehab249
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34226923; ● Summary page in Scopus @ Elsevier: 2-s2.0-85120384111

(DOI: 10.1093/eurheartj/ehab249, PubMed: 34226923, Elsevier: Scopus) Y Okushi, Kenya Kusunose, Y Okayama, Robert Zheng, M Nakai, Y Sumita, Takayuki Ise, Takeshi Tobiume, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Acute Hospital Mortality of Venous Thromboembolism in Patients With Cancer From Registry Data,
Journal of the American Heart Association, Vol.10, No.11, e019373, 2021.

(要約): Background The prognosis of patients with cancer-venous thromboembolism (VTE) is not well known because of a lack of registry data. Moreover, there is also no knowledge on how specific types are related to prognosis. We sought to evaluate the clinical characteristics and outcomes of patients with cancer-associated VTE, compared with a matched cohort without cancer using real-world registry data of VTE. Methods and Results This study was based on the Diagnosis Procedure Combination database in the JROAD-DPC (Japanese Registry of All Cardiac and Vascular Diseases and the Diagnosis Procedure Combination). Of 5 106 151 total patients included in JROAD-DPC, we identified 49 580 patients who were first hospitalized with VTE from April 2012 to March 2017. Propensity score was estimated with a logistic regression model, with cancer as the dependent variable and 18 clinically relevant covariates. After propensity matching, there were 25 148 patients with VTE with or without cancer. On propensity score-matched analysis with 25 148 patients with VTE, patients with cancer had higher total in-hospital mortality within 7 days (1.3% versus 1.1%, odds ratio [OR], 1.66; 95% CI, 1.31-2.11; <0.0001), 14 days (2.5% versus 1.5%, OR, 2.07; 95% CI, 1.72-2.49; <0.0001), and 30 days (4.8% versus 2.0%, OR, 2.85; 95% CI, 2.45-3.31; <0.0001). On analysis for each type of cancer, in-hospital mortality in 11 types of cancer was significantly high, especially pancreas (OR, 12.96; 95% CI, 6.41-26.20), biliary tract (OR, 8.67; 95% CI, 3.00-25.03), and liver (OR, 7.31; 95% CI, 3.05-17.50). Conclusions Patients with cancer had a higher in-hospital acute mortality for VTE than those without cancer, especially in pancreatic, biliary tract, and liver cancers.
(徳島大学機関リポジトリ): ● Metadata: 116140
(出版サイトへのリンク): ● Publication site (DOI): 10.1161/JAHA.120.019373
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34027673; ● Search Scopus @ Elsevier (PMID): 34027673; ● Search Scopus @ Elsevier (DOI): 10.1161/JAHA.120.019373

(徳島大学機関リポジトリ: 116140, DOI: 10.1161/JAHA.120.019373, PubMed: 34027673) Miharu Arase, Kenya Kusunose, N Yamaguchi, Yukina Hirata, Susumu Nishio, Y Okushi, Takayuki Ise, Takeshi Tobiume, Koji Yamaguchi, Daiju Fukuda, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Cardiac reserve by 6-minute walk stress echocardiography in systemic sclerosis.,
Open Heart, Vol.8, No.1, e001559, 2021.

(徳島大学機関リポジトリ): ● Metadata: 116465
(出版サイトへのリンク): ● Publication site (DOI): 10.1136/openhrt-2020-001559
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1136/openhrt-2020-001559

(徳島大学機関リポジトリ: 116465, DOI: 10.1136/openhrt-2020-001559) Kenya Kusunose, Y Okushi, Y Okayama, Robert Zheng, M Abe, M Nakai, Y Sumita, Takayuki Ise, Takeshi Tobiume, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Association between Vitamin D and Heart Failure Mortality in 10,974 Hospitalized Individuals.,
Nutrients, Vol.13, No.2, 335, 2021.

(要約): A broad range of chronic conditions, including heart failure (HF), have been associated with vitamin D deficiency. Existing clinical trials involving vitamin D supplementation in chronic HF patients have been inconclusive. We sought to evaluate the outcomes of patients with vitamin D supplementation, compared with a matched cohort using real-world big data of HF hospitalization. This study was based on the Diagnosis Procedure Combination database in the Japanese Registry of All Cardiac and Vascular Datasets (JROAD-DPC). After exclusion criteria, we identified 93,692 patients who were first hospitalized with HF between April 2012 and March 2017 (mean age was 79 ± 12 years, and 52.2% were male). Propensity score (PS) was estimated with logistic regression model, with vitamin D supplementation as the dependent variable and clinically relevant covariates. On PS-matched analysis with 10,974 patients, patients with vitamin D supplementation had lower total in-hospital mortality (6.5 vs. 9.4%, odds ratio: 0.67, < 0.001) and in-hospital mortality within 7 days and 30 days (0.9 vs. 2.5%, OR, 0.34, and 3.8 vs. 6.5%, OR: 0.56, both < 0.001). In the sub-group analysis, mortalities in patients with age < 75, diabetes, dyslipidemia, atrial arrhythmia, cancer, renin-angiotensin system blocker, and β-blocker were not affected by vitamin D supplementation. Patients with vitamin D supplementation had a lower in-hospital mortality for HF than patients without vitamin D supplementation in the propensity matched cohort. The identification of specific clinical characteristics in patients benefitting from vitamin D may be useful for determining targets of future randomized control trials.
(徳島大学機関リポジトリ): ● Metadata: 116464
(出版サイトへのリンク): ● Publication site (DOI): 10.3390/nu13020335
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33498709; ● Summary page in Scopus @ Elsevier: 2-s2.0-85099832739

(徳島大学機関リポジトリ: 116464, DOI: 10.3390/nu13020335, PubMed: 33498709, Elsevier: Scopus) Akira Takashima, Shusuke Yagi, Koji Yamaguchi, Kiyoe Kurahashi, Yuko Kojima, Robert Zheng, Takayuki Ise, Kenya Kusunose, Sumiko Yoshida, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Ken-ichi Aihara, Masashi Akaike and Masataka Sata :
Congenital Hypogonadotropic Hypogonadism with Early-Onset Coronary Artery Disease.,
The Journal of Medical Investigation : JMI, Vol.68, No.1.2, 189-191, 2021.

(要約): The patient with congenital hypogonadotropic hypogonadism (HH) shows low serum levels of androgen, which is a group of sex hormones including testosterone, caused by the decreased gonadotropin release in the hypothalamus. Recent reports showed androgens exert protective effects against insulin resistance or atherosclerotic diseases, such as diabetes mellitus or coronary artery disease. However, whether the juvenile hypogonadism affects the diabetes or cardiovascular disease is unclear. We report a case of a middle-aged man with congenital HH who had severe coronary artery disease complicated with metabolic disorders. J. Med. Invest. 68 : 189-191, February, 2021.
(徳島大学機関リポジトリ): ● Metadata: 116019
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.68.189
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33994469; ● Search Scopus @ Elsevier (PMID): 33994469; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.68.189

(徳島大学機関リポジトリ: 116019, DOI: 10.2152/jmi.68.189, PubMed: 33994469) Yutaka Kawabata, Takeshi Soeki, Hiroyuki Ito, Tomomi Matsuura, Kenya Kusunose, Takayuki Ise, Koji Yamaguchi, Takeshi Tobiume, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Tetsuzo Wakatsuki, M Kitani, K Kawano, Y Taketani and Masataka Sata :
Effects of L-/N-Type Calcium Channel Blockers on Angiotensin II-Renin Feedback in Hypertensive Patients,
International Journal of Hypertension, 6653851, 2020.

(徳島大学機関リポジトリ): ● Metadata: 115937
(出版サイトへのリンク): ● Publication site (DOI): 10.1155/2020/6653851
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33489354; ● Summary page in Scopus @ Elsevier: 2-s2.0-85098701678

(徳島大学機関リポジトリ: 115937, DOI: 10.1155/2020/6653851, PubMed: 33489354, Elsevier: Scopus) Takeshi Tobiume, R Kato, Tomomi Matsuura, Kazuhisa Matsumoto, M Hara, N Takamori, Y Taketani, K Okwa, Takayuki Ise, Kenya Kusunose, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Tetsuzo Wakatsuki, Takeshi Soeki, Masataka Sata and K Matsumoto :
Antegrade slow pathway mapping of typical atrioventricular nodal reentrant tachycardia based on direct slow pathway capture,
Journal of Arrhythmia, Vol.37, No.1, 128-139, 2020.

(徳島大学機関リポジトリ): ● Metadata: 116343
(出版サイトへのリンク): ● Publication site (DOI): 10.1002/joa3.12484
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33664895; ● Summary page in Scopus @ Elsevier: 2-s2.0-85099515348

(徳島大学機関リポジトリ: 116343, DOI: 10.1002/joa3.12484, PubMed: 33664895, Elsevier: Scopus) S Sueda, T Shinohara, N Takahashi, J Shite, T Shoji, M Akao, Y Kijima, T Masuyama, T Miyaji, K Yamamoto, Y Iwasaki, R Yoshida, S Nakamura, Y Ogino, K Kimura, M Sasai, M Sasai, H Suzuki, Tetsuzo Wakatsuki, H Asajima, H Teragawa, T Ishikawa, K Kitamura, T Oda, T Nakayama, Y Kobayashi, D Sunada, M Yamaki, F Nishizaki, Y Tomita, K Usuda, H Fujinaga, S Kuramitsu, K Andou, T Kiyooka, K Kadota, Y Ishii, H Ohtani, Y Maekawa, E Taguchi, K Nakao, N Kobayashi, Y Seino, H Nakagawa, Y Saito, I Komuro, Y Sasaki, S Ikeda, O Yamaguchi, A Kakutani, T Imanaka, M Ishihara, M Ishii, K Kaikita and K Tsujita :
Questionnaire in patients with aborted sudden cardiac death due to coronary spasm in Japan,
Heart and Vessels, Vol.35, No.12, 1640-1649, 2020.

(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s00380-020-01644-7
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32533313; ● Summary page in Scopus @ Elsevier: 2-s2.0-85086455256

(DOI: 10.1007/s00380-020-01644-7, PubMed: 32533313, Elsevier: Scopus) Hirotoshi Watanabe, Takeshi Morimoto, Manabu Ogita, Satoru Suwa, Masahiro Natsuaki, Nobuhiro Suematsu, Yorihiko Koeda, Yoshihiro Morino, Akira Nikaido, Yoshiki Hata, Masayuki Doi, Kiyoshi Hibi, Kazuo Kimura, Shunsuke Yoda, Takeo Kaneko, Koji Nishida, Kazuya Kawai, Koji Yamaguchi, Tetsuzo Wakatsuki, Norimasa Tonoike, Masashi Yamamoto, Shogo Shimizu, Takao Shimohama, Junya Ako and Takeshi Kimura :
Influence of CYP2C19 genotypes for the effect of 1-month dual antiplatelet therapy followed by clopidogrel monotherapy relative to 12-month dual antiplatelet therapy on clinical outcomes after percutaneous coronary intervention: a genetic substudy from the STOPDAPT-2.,
Cardiovascular Intervention and Therapeutics, 2020.

(要約): The ultra-short dual antiplatelet therapy (DAPT) followed by P2Y inhibitor monotherapy might be promising after percutaneous coronary intervention (PCI). However, CYP2C19 loss-of-function (LOF) alleles have been reported to diminish the effect of clopidogrel, and clopidogrel monotherapy has a concern about the increased ischemic risk for patients with such alleles. STOPDAPT-2 is the multicenter prospective open-label, but adjudicator-blinded randomized control study comparing 1-month DAPT followed by clopidogrel monotherapy with the standard 12-month DAPT after PCI with cobalt-chromium everolimus-eluting stents. Among the participants of STOPDAPT-2, selected patients participated in a substudy of the CYP2C19 gene test. Patients with two CYP2C19*2 or *3 alleles were defined as the poor metabolizer (PM), one allele as the intermediate metabolizer (IM), and no allele as the extensive metabolizer (EM). The primary endpoint was the composite of cardiovascular and bleeding events, as defined in STOPDAPT-2. Among 750 (24.9%) patients with known CYP2C19 genotypes, 129 (17.2%) were PM, 367 (49.0%) were IM, and 254 (33.9%) were EM. The hazard ratios of 1-month DAPT relative to 12-month DAPT for the primary endpoint in PM, IM, and EM strata were 0.66 (95% CI 0.11-3.94), 1.94 (95% CI 0.60-6.31), and 0.21 (95% CI 0.02-1.78), respectively (P interaction = 0.17), and those for cardiovascular composite endpoint were 1.00 (95% CI 0.14-7.10), 6.10 (95% CI 0.75-49.55), and 0.26 (95% CI 0.03-2.34), respectively (P interaction = 0.12). In conclusion, for the selected patients in STOPDAPT-2 trial, CYP2C19 LOF alleles had no significant, consistent interaction with the effect of 1-month DAPT relative to 12-month DAPT for clinical outcomes, although the study was overtly underpowered. TRIAL REGISTRY: STOPDAPT-2 ClinicalTrials.gov number, NCT02619760.
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s12928-020-00719-6
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33184726; ● Summary page in Scopus @ Elsevier: 2-s2.0-85095936254

(DOI: 10.1007/s12928-020-00719-6, PubMed: 33184726, Elsevier: Scopus) Masato Nakamura, Yoshihiro Morino, Tsunekazu Kakuta, Yoshiki Hata, Itaru Takamisawa, Kengo Tanabe, Hitoshi Anzai, Akihiko Takahashi, Kazushige Kadota, Hiroshi Suzuki, Tetsuzo Wakatsuki, Hideki Okayama, Jun Yamashita, Takashi Akasaka, Hiroyoshi Yokoi, Takuo Nakagami, Yoshiharu Higuchi, Junichi Yamaguchi, Takumi Kimura, Atsushi Harada, Takeshi Kuroda, Atsushi Takita, Raisuke Iijima, Yoshitaka Murakami and Shigeru Saito :
Monotherapy With Prasugrel After Dual-Antiplatelet Therapy for Japanese Percutaneous Coronary Intervention Patients With High Bleeding Risk - A Prospective Cohort Study (PENDULUM mono Study).,
Circulation Journal, Vol.85, No.1, 27-36, 2020.

(要約): The risks of bleeding and cardiovascular events in high bleeding risk (HBR) Japanese patients undergoing percutaneous coronary intervention (PCI) while receiving single-antiplatelet therapy (SAPT) remains unknown. We aimed to evaluate the frequency of bleeding and cardiovascular events associated with prasugrel monotherapy after short-term dual-antiplatelet therapy (DAPT) in Japanese HBR patients after PCI.Methods and Results:The PENDULUM mono study was a multicenter, non-interventional, prospective registry (n=1,173). The primary endpoint was the cumulative incidence of clinically relevant bleeding (CRB; Bleeding Academic Research Consortium types 2, 3, and 5) from 1 to 12 months after PCI. Secondary endpoints included major adverse cardiac and cerebrovascular events (MACCE). The proportion of patients who received prasugrel monotherapy at 12 months after PCI was 79.7%, and no cases of stent thrombosis were observed among these patients. The cumulative incidence of CRB was 3.2% from 1 to 12 months after PCI; that of MACCE was 3.8%. Severe anemia, chronic kidney disease, oral anticoagulant use at discharge, and heart failure were significantly associated with CRB. Among HBR patients undergoing PCI who were not suitable for concomitant aspirin and were scheduled for prasugrel monotherapy, most patients were on prasugrel monotherapy after DAPT. Cumulative incidences of CRB and MACCE after periprocedural period were 3.2% and 3.8%, respectively, and no cases of stent thrombosis were reported. SAPT might be a suitable alternative to DAPT.
(徳島大学機関リポジトリ): ● Metadata: 116292
(出版サイトへのリンク): ● Publication site (DOI): 10.1253/circj.CJ-20-0786
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33162490; ● Summary page in Scopus @ Elsevier: 2-s2.0-85098659590

(徳島大学機関リポジトリ: 116292, DOI: 10.1253/circj.CJ-20-0786, PubMed: 33162490, Elsevier: Scopus) Kenya Kusunose, nao Yamada, Hirotsugu Yamada, Susumu Nishio, Yoshihito Saijoh, Yukina Hirata, Yuta Torii, Takayuki Ise, Koji Yamaguchi, Daiju Fukuda, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Association between Right Ventricular Contractile Function and Cardiac Events in Isolated Post-capillary and Combined Pre- and Post-capillary Pulmonary Hypertension,
Journal of Cardiac Failure, Vol.26, No.1, 43-51, 2020.

(要約): Recent studies have shown that patients with combined pre- and postcapillary pulmonary hypertension (CpcPH) had worse outcomes than those with isolated postcapillary pulmonary hypertension (IpcPH). However, the prognostic factors including right ventricular (RV) function have not been well documented. The aim of this study was to assess the differentiation of PH phenotypes, using echocardiography, and the association between RV longitudinal strain and cardiac events. We prospectively recruited consecutive patients who had undergone right heart catheterization. The primary endpoint was cardiovascular death or readmission due to heart failure. We included 137 patients with Group 2 PH. A RV longitudinal strain of 17% was sensitive (85%) and specific (70%) to determine the CpcPH. During a median period of 31 months, 43 patients experienced the primary endpoint during follow-up. In a multivariate analysis, RV longitudinal strain was associated with the primary endpoint in both CpcPH and IpcPH (HR: 0.84, P = 0.003; HR: 0.86, P = 0.001). Lower RV longitudinal strain was independently associated with worse outcomes in CpcPH and IpcPH. RV longitudinal strain may play a prognostic role in PH phenotypes.
(徳島大学機関リポジトリ): ● Metadata: 114190
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.cardfail.2019.08.021
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31487533; ● Summary page in Scopus @ Elsevier: 2-s2.0-85072539026

(徳島大学機関リポジトリ: 114190, DOI: 10.1016/j.cardfail.2019.08.021, PubMed: 31487533, Elsevier: Scopus) Yuta Torii, Kenya Kusunose, Robert Zheng, Hirotsugu Yamada, Rie Amano, Rikizo Matsumoto, Yukina Hirata, Susumu Nishio, Nao Yamada, Takayuki Ise, Koji Yamaguchi, Takeshi Tobiume, Daiju Fukuda, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki, Yoshihiro Okayama and Masataka Sata :
Association between Sarcopenia/Lower Muscle Mass and Short-Term Regression of Deep Vein Thrombosis Using Direct Oral Anticoagulants,
International Heart Journal, Vol.61, No.4, 787-794, 2020.

(要約): Advanced age, obesity, and muscle weakness are independent factors in the onset of deep vein thrombosis (DVT). Recently, an association between sarcopenia and DVT has been reported. We hypothesized that sarcopenia related factors, observed by ultrasonography, are associated with the regression effect on the thrombus following anticoagulation therapy. The present study focused on gastrocnemius muscle (GCM) thickness and the GCM's internal echogenic brightness. We examined the association with DVT regression following direct oral anticoagulants (DOACs) treatment.The prospective cohort study period was between October 2017 and August 2018. We enrolled 46 patients diagnosed with DVT by ultrasonography, who were aged >60 years old and treated with DOACs. Sarcopenia was evaluated using the Asian Working Group for Sarcopenia flowchart. The average DOACs treatment period was 94 days, and 29 patients exhibited thrombus regression. On univariate logistic regression analysis, sarcopenia, average GCM diameter index, and gastrocnemius integrated backscatter index were significantly associated with thrombus regression. In a multivariate model, only the average GCM diameter index correlated with thrombus regression.The average GCM diameter index is associated with DVT regression treated with DOACs. Considering the GCM diameter during DVT treatment can be a marker to make a decision for the treatment of DVT.
(キーワード): Aged / Aged, 80 and over / Factor Xa Inhibitors / 女性 (female) / Humans / 男性 (male) / Middle Aged / Muscle, Skeletal / Prospective Studies / Sarcopenia / Ultrasonography / Venous Thrombosis
(出版サイトへのリンク): ● Publication site (DOI): 10.1536/ihj.20-032
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32684602; ● Summary page in Scopus @ Elsevier: 2-s2.0-85088879684

(DOI: 10.1536/ihj.20-032, PubMed: 32684602, Elsevier: Scopus) Kenya Kusunose, M Fujiwara, Hirotsugu Yamada, Susumu Nishio, Y Saijo, N Yamada, Yukina Hirata, Yuta Torii, Takayuki Ise, Koji Yamaguchi, Daiju Fukuda, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Deterioration of Biventricular Strain Is an Early Marker of Cardiac Involvement in Confirmed Sarcoidosis,
European Heart Journal Cardiovascular Imaging, Vol.21, No.7, 796-804, 2020.

(要約): Risk assessment of developing cardiac involvement in systemic sarcoidosis can be challenging because of limited data. Recently, attention has been given to left ventricular and right ventricular (LV and RV) involvement in cardiac sarcoidosis (CS) and its prevalence, relevance, and prognostic value. The aim of this study was to assess the role of biventricular strain to predict prognosis in confirmed sarcoidosis patients. LV and RV longitudinal strains (LSs) were evaluated by 2D speckle tracking in 139 consecutive confirmed sarcoidosis patients without other pre-existing structural heart diseases, and 52 age- and gender-matched control subjects. The primary endpoint was CS-related events (cardiac death or development of cardiac involvement). Sarcoidosis without cardiac involvement had significantly lower LV and RV free wall LS compared with control subjects. Basal LS had a higher area under the curve for differentiation of sarcoidosis in patients without cardiac involvement compared to control (cut-off value: -18% with 89% sensitivity and 69% specificity). During a median period of 50 months, the occurrence of CS-related events was observed in 20 patients. In a multivariate analysis, basal LV LS and RV free wall LS were associated with the events [hazard ratio (HR) 0.72, P < 0.001 and HR: 0.83, P = 0.006, respectively]. Patients with impaired biventricular function had significantly shorter event-free survival than those with preserved biventricular function (P < 0.001). Deterioration of biventricular strain was associated with CS-related events. This information might be useful for clinical evaluation and follow-up in sarcoidosis.
(出版サイトへのリンク): ● Publication site (DOI): 10.1093/ehjci/jez235
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31566217; ● Summary page in Scopus @ Elsevier: 2-s2.0-85086792785

(DOI: 10.1093/ehjci/jez235, PubMed: 31566217, Elsevier: Scopus) Hiroyuki Ito, Tetsuzo Wakatsuki, Koji Yamaguchi, Daiju Fukuda, Yutaka Kawabata, Tomomi Matsuura, Kenya Kusunose, Takayuki Ise, Takeshi Tobiume, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Yoshihiro Tsuruo and Masataka Sata :
Atherosclerotic Coronary Plaque Is Associated With Adventitial Vasa Vasorum and Local Inflammation in Adjacent Epicardial Adipose Tissue in Fresh Cadavers,
Circulation Journal, Vol.84, No.5, 769-775, 2020.

(徳島大学機関リポジトリ): ● Metadata: 116640
(出版サイトへのリンク): ● Publication site (DOI): 10.1253/circj.CJ-19-0914
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32281556; ● Summary page in Scopus @ Elsevier: 2-s2.0-85083919450

(徳島大学機関リポジトリ: 116640, DOI: 10.1253/circj.CJ-19-0914, PubMed: 32281556, Elsevier: Scopus) Shozo Sueda, Tetsuji Shinohara, Naohiko Takahashi, Junya Shite, Toshihiro Shoji, Masaharu Akao, Yoshiyuki Kijima, Tohru Masuyama, Tsuyoshi Miyaji, Katsuhito Yamamoto, Iwasaki Yoshihiro, Yoshida Ritsu, Shigeru Nakamura, Yutaka Ogino, Kazuo Kimura, Masahiro Sasai, Hiroshi Suzuki, Tetsuzo Wakatsuki, Hiroshi Asajima, Hiroki Teragawa, Tetsunori Ishikawa, Kazuo Kitamura, Tsuyoshi Oda, Takashi Nakayama, Yoshio Kobayashi, Daiki Sunada, Masaru Yamaki, Fumie Nishizaki, Hirofumi Tomita, Kazuo Usuda, Hiroyuki Fujinaga, Shoichi Kuramitsu, Kenji Ando, Takahiko Kiyooka, Kazushige Kadota, Yoshinao Ishii, Hayato Ohtani, Yuichiro Maekawa, Eiji Taguchi, Koichi Nakao, Nobuaki Kobayashi, Yoshihiko Seino, Hitoshi Nakagawa, Yoshihiko Saito, Issei Komuro, Yasuhiro Sasaki, Shuntaro Ikeda, Osamu Yamaguchi, Akiyoshi Kakutani, Takahiro Imanaka, Masaharu Ishihara, Masanobu Ishii, Koichi Kaikita and Kenichi Tsujita :
Clinical Therapy in Patients with Aborted Sudden Cardiac Death due to Coronary Spasm,
Journal of Coronary Artery Disease, Vol.26, No.4, 91-99, 2020.

(キーワード): aborted sudden cardiac death / calcium channel blocker / coronary vasodilator / implantable cardioverter-defibrillator / spasm provocation test under the medication
(出版サイトへのリンク): ● Publication site (DOI): 10.7793/jcad.26.20-00025
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390286981363241728; ● Search Scopus @ Elsevier (DOI): 10.7793/jcad.26.20-00025

(DOI: 10.7793/jcad.26.20-00025, CiNii: 1390286981363241728) Kenya Kusunose, Yuta Torii, Hirotsugu Yamada, Susumu Nishio, Yukina Hirata, Yoshihito Saijoh, Takayuki Ise, Koji Yamaguchi, Daiju Fukuda, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Association of Echocardiography Before Major Elective Non-Cardiac Surgery With Improved Postoperative Outcomes - Possible Implications for Patient Care.,
Circulation Journal, Vol.83, No.12, 2512-2519, 2019.

(要約): Whether preoperative echocardiography improves postoperative outcomes is not well established, so we examined the value of echocardiographic assessment on the onset of postoperative heart failure (HF), and determining which patients benefitted most from undergoing echocardiography prior to major elective non-cardiac surgery.Methods and Results:We identified all patients aged 50 years and older who had major elective non-cardiac surgery, and excluded patients with previously identified severe cardiovascular disease. The primary endpoint was the onset of HF during hospitalization. A total of 806 patients were included in the analysis. During hospitalization, 49 patients (6%) reached the primary endpoint. Within the matched cohort, preoperative echocardiography was associated with a statistically significant decrease in postoperative HF (hazard ratio: 0.46, P=0.01). In subgroup analyses, age, sex, body surface area, hypertension, diabetes mellitus, prior HF, surgical type, chronic kidney disease, pulmonary disease, and malignancy influenced the association of echocardiography with postoperative HF. The use of echocardiography in elderly patients with certain risk factors was associated with improved postoperative outcomes. The basis for this finding remains to be determined; particularly whether echocardiography is simply a marker of a population with better outcomes or whether it leads to better management that improves outcomes.
(キーワード): Aged / Echocardiography / Female / Heart Failure / Humans / Incidence / Japan / Male / Middle Aged / Predictive Value of Tests / Preoperative Care / Retrospective Studies / Risk Assessment / Risk Factors / Surgical Procedures, Operative / Time Factors / Treatment Outcome
(徳島大学機関リポジトリ): ● Metadata: 114189
(出版サイトへのリンク): ● Publication site (DOI): 10.1253/circj.CJ-19-0663
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31611537; ● Search Scopus @ Elsevier (PMID): 31611537; ● Search Scopus @ Elsevier (DOI): 10.1253/circj.CJ-19-0663

(徳島大学機関リポジトリ: 114189, DOI: 10.1253/circj.CJ-19-0663, PubMed: 31611537) Kenya Kusunose, Hirotsugu Yamada, Susumu Nishio, Yukina Hirata, Yoshihito Saijoh, Yuta Torii, nao Yamada, Takayuki Ise, Koji Yamaguchi, Daiju Fukuda, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Pulmonary Artery Hypertension-Specific Therapy Improves Exercise Tolerance and Outcomes in Exercise-Induced Pulmonary Hypertension,
JACC. Cardiovascular Imaging, Vol.12, No.12, 2576-2579, 2019.

(徳島大学機関リポジトリ): ● Metadata: 114191
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jcmg.2019.07.002
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31422131; ● Search Scopus @ Elsevier (PMID): 31422131; ● Search Scopus @ Elsevier (DOI): 10.1016/j.jcmg.2019.07.002

(徳島大学機関リポジトリ: 114191, DOI: 10.1016/j.jcmg.2019.07.002, PubMed: 31422131) Yuta Torii, Kenya Kusunose, Hirotsugu Yamada, Susumu Nishio, Yukina Hirata, Amano Rie, Yamao Masami, Zheng Robert, Yoshihito Saijoh, nao Yamada, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Updated Left Ventricular Diastolic Function Recommendations and Cardiovascular Events in Patients with Heart Failure Hospitalization,
Journal of the American Society of Echocardiography, Vol.32, No.10, 1286-1297, 2019.

(要約): Evaluation of diastolic dysfunction is crucial in determining elevated left atrial pressure. However, a validation of the long-term prognostic value of the newly proposed algorithm updated in 2016 has not been performed. The aim of the present study was to investigate the relative value of the updated 2016 diastolic dysfunction grading system for the incidence of readmission in patients with heart failure (HF) with reduced ejection fraction (HFrEF) and HF with preserved ejection fraction (HFpEF). Two hundred thirty-two patients hospitalized with HF were retrospectively evaluated. Subjects were divided into two subgroups: those with HFrEF (n = 127) and those with HFpEF (n = 105). Readmission risk scores were calculated using the Yale Center for Outcomes Research and Evaluation HF, LACE index, and HOSPITAL scores. The primary end point was readmission following HF and cardiac death. Over a period of 24 months, 86 patients were either readmitted or died. Multivariate Cox analysis was performed on both the HFrEF and HFpEF groups. In the HFrEF group, both the 2009 and 2016 algorithms had superior incremental value for the association of the primary end point to several readmission risk scores. In the HFpEF group, only the 2016 algorithm led to significant improvement in association with the primary end point. The 2016 algorithm had incremental value over several readmission risk scores alone. The recommendations of the 2016 algorithm can be useful for readmission and cardiac mortality risk assessment in patients with HFrEF and HFpEF. The use of echocardiography to estimate elevated left atrial pressure appears to identify a higher risk group and may allow a more tailored approach to therapy.
(徳島大学機関リポジトリ): ● Metadata: 114193
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.echo.2019.06.006
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31378421; ● Summary page in Scopus @ Elsevier: 2-s2.0-85069976367

(徳島大学機関リポジトリ: 114193, DOI: 10.1016/j.echo.2019.06.006, PubMed: 31378421, Elsevier: Scopus) Shusuke Yagi, Daisuke Kondo, Takayuki Ise, Daiju Fukuda, Koji Yamaguchi, Tetsuzo Wakatsuki, Yutaka Kawabata, Hiroyuki Ito, Yoshihito Saijo, Hiromitsu Seno, Kumiko Sutou, Rie Ueno, Takafumi Todoroki, Kenya Kusunose, Tomomi Matsuura, Takeshi Tobiume, Hirotsugu Yamada, Takeshi Soeki, Michio Shimabukuro, Ken-ichi Aihara, Masashi Akaike and Masataka Sata :
Association of Decreased Docosahexaenoic Acid Level After Statin Therapy and Low Eicosapentaenoic Acid Level with In-Stent Restenosis in Patients with Acute Coronary Syndrome,
Journal of Atherosclerosis and Thrombosis, Vol.26, No.3, 272-281, 2019.

(要約): It is speculated that statin therapy modulates the synthesis of polyunsaturated fatty acids (PUFA), including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). However, the data available on the effects of statin therapy on the serum levels of PUFA and the subsequent impact on in-stent restenosis (ISR) in patients with acute coronary syndrome (ACS) are limited. A total of 120 ACS patients who received emergent coronary stent implantation, follow-up coronary angiography to evaluate ISR, and new statin therapy were enrolled. We measured the serum levels of the PUFA and lipids at the onset of ACS and at the follow-up coronary angiography. The follow-up coronary angiography revealed 38 ISR cases. New statin therapy significantly reduced the serum levels of DHA and low-density lipoprotein cholesterol (LDL-C), while it did not affect EPA level. Single regression analysis revealed that a decreased serum level of LDL-C was associated with decreased DHA level. The multiple logistic regression analysis revealed that the decreased DHA level after statin therapy and low serum level of EPA on admission were determinants of prevalence of ISR. Statin therapy decreased the serum level of DHA with a parallel reduction in LDL-C level in patients with ACS. Decreased DHA level after statin therapy and low EPA level on admission are risk factors for ISR, indicating that in patients with ACS, decreased serum levels of DHA may be a residual target for the prevention of ISR.
(キーワード): Acute Coronary Syndrome / Aged / Coronary Restenosis / Docosahexaenoic Acids / Eicosapentaenoic Acid / 女性 (female) / Follow-Up Studies / Humans / Hydroxymethylglutaryl-CoA Reductase Inhibitors / 男性 (male) / Prognosis / Retrospective Studies / Risk Factors / Stents
(徳島大学機関リポジトリ): ● Metadata: 113220
(出版サイトへのリンク): ● Publication site (DOI): 10.5551/jat.44735
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30135329; ● Summary page in Scopus @ Elsevier: 2-s2.0-85062425735

(徳島大学機関リポジトリ: 113220, DOI: 10.5551/jat.44735, PubMed: 30135329, Elsevier: Scopus) 高橋未奈, 飛梅威, 松本和久, 松浦朋美, 添木武, 藤本裕太, 原田貴文, Zheng Robert, 數藤久美子, 西條良仁, 上野理絵, 川端豊, 坂東美佳, 山田なお, 伊藤浩敬, 轟貴史, 伊勢孝之, 楠瀬賢也, 山口浩司, 八木秀介, 福田大受, 山田博胤, 若槻哲三, 佐田政隆 :
大動脈弁人工弁(機械弁)置換術後遠隔期に生じたOMI-VT stormに対し経心房中隔的に施行したカテーテルアブレーションが著効した1例,
四国医学雑誌, Vol.74, No.56, 201-208, 2019年.

(要約): A 68-year-old woman with VT storm and frequent appropriate ICD therapy was referred for catheter ablation. Her past history was notable for aortic valve replacement by mechanical valve due to infectious endocarditis 17 years prior to presentation and left ventricular apical old myocardial infarction with unknown onset. At 67 years old, She admitted to the prior hospital due to ventricular tachycardia with LBBB and superior axis at heart rate of 210 per minutes. Administration of amiodarone and magnesium sulfate was ineffective and cardioversion of 200J was successfully terminated the tachycardia. Intra-cardiac defibrillator was implanted and the administration of amiodarone and mexiletine was started. 5 months after, she admitted to the hospital due to the frequent appropriate shock against the same ventricular tachycardia. Administration of lidocaine, sotalol, pilsicainide, and magnesium sulfate could not control the tachycardia and she was referred to our hospital for catheter ablation. During the first session, ventricular tachycardia was easily induced and electroanatomical mapping was performed both during tachycardia and during sinus rhythm. Late diastolic potential preceding the onset of QRS wave by 45ms was detected at the infero-septal side of the apical aneurysm. 7 5s of the RF energy application at this site could terminate the tachycardia and thereafter no ventricular tachycardia was induced. But after dose-reduction or cessation of some anti-arrhythmic drugs, ventricular tachycardia was recurred and second session was performed. This time, no ventricular tachycardia was induced, then we performed isthmus transection and core isolation against the apical aneurysm. Thereafter no ventricular tachycardia was occurred in spite of dose-reduction or cessation of some anti-arrhythmic drugs.
(キーワード): ventricular tachycardia / storm / old myocardial infarction / catheter ablation / aortic valve replacement
(徳島大学機関リポジトリ): ● Metadata: 112988
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1050020697876465664

(徳島大学機関リポジトリ: 112988, CiNii: 1050020697876465664) Shusuke Yagi, Robert Zheng, Seiichi Nishiyama, Yutaka Kawabata, Takayuki Ise, Kosuke Sugiura, Haruhiko Yoshinari, Toshihiko Nishisho, Yoshimi Bando, Kumiko Kagawa, Daiju Fukuda, Tomohiro Soga, Yoshihito Saijoh, Kenya Kusunose, Koji Yamaguchi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Shinji Kawahito, Masashi Akaike and Masataka Sata :
Osteolytic primary bone lymphoma in the multiple bones,
The Journal of Medical Investigation : JMI, Vol.66, No.3,4, 347-350, 2019.

(要約): Primary non-Hodgkin bone lymphoma (PBL) can involve solitary or multiple destructive bone lesions such as those of the femur or pelvis humerus, and some cases have osteolytic lesions. PBL is a rare disease in adults. Thus, PBL is rarely considered a differential diagnosis of the osteolytic tumor. In addition, PBL can be underdiagnosed because patients do not experience symptoms or show objective abnormalities in the early stage. Here, we reported an elderly patient with PBL in multiple bones, including the cranial and femoral bones that were fractured due to falling. J. Med. Invest. 66 : 347-350, August, 2019.
(徳島大学機関リポジトリ): ● Metadata: 114167
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.66.347
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31656303; ● Summary page in Scopus @ Elsevier: 2-s2.0-85074142443

(徳島大学機関リポジトリ: 114167, DOI: 10.2152/jmi.66.347, PubMed: 31656303, Elsevier: Scopus) Shusuke Yagi, Itsuro Endo, Taichi Murakami, Tetsuya Hida, Yousuke Yamamoto, Tomohiro Soga, Takayuki Ise, Kenya Kusunose, Koji Yamaguchi, Daiju Fukuda, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Shinji Kawahito and Masataka Sata :
Adult onset of Immunoglobulin A vasculitis - A case report,,
The Journal of Medical Investigation : JMI, Vol.66, No.3,4, 344-346, 2019.

(要約): Immunoglobulin A vasculitis (IgAV), formerly known as Henoch-Schönlein purpura, primarily occurs during childhood between the ages of 3 and 15 years and is the most common form of systemic vasculitis in children ; its occurrence in adults has been rarely reported. Such low incidence could be attributable to either under-diagnosis or misdiagnosis. Thus, not only pediatricians but also physicians should be able to diagnose IgAV accurately to manage the patients appropriately and avoid its associated complications. In addition, treatment of adult onset IgAV with renal involvement has not been fully established yet. We describe here a case of adult onset IgAV complicated by proteinuria and pharyngitis, which was cured by no specific treatment. J. Med. Invest. 66 : 344-346, August, 2019.
(キーワード): Acetaminophen / Adult / Factor XIII / Humans / Immunoglobulin A / Male / Pharyngitis / Proteinuria / Purpura, Schoenlein-Henoch
(徳島大学機関リポジトリ): ● Metadata: 114166
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.66.344
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31656302; ● Search Scopus @ Elsevier (PMID): 31656302; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.66.344

(徳島大学機関リポジトリ: 114166, DOI: 10.2152/jmi.66.344, PubMed: 31656302) Shusuke Yagi, Rie Ueno, Kumiko Sutou, Tetsuzo Wakatsuki, Koji Yamaguchi, Yoshihito Saijo, Tomoya Hara, Takayuki Ise, Kenya Kusunose, Mika Bando, Tomomi Matsuura, Takeshi Tobiume, Hirotsugu Yamada, Daiju Fukuda, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Lambda-like J wave due to acute myocardial infarction of the diagonal branch,
The Journal of Medical Investigation : JMI, Vol.66, No.1,2, 185-187, 2019.

(要約): The culprit lesion of acute myocardial infarction could be predicted by electrocardiogram findings. However, we experienced some cases with coronary angiographic finding in the area of ST-T elevation that was different from that predicted. The lambda-like J wave could be caused by ischemia although the mechanism has not been fully elucidated. We report a case of acute myocardial infarction that showed discrepancy between ST-T elevation with lambda-like ischemic J wave in a broad area and coronary angiographical finding of diagonal branch occlusion. J. Med. Invest. 66 : 185-187, February, 2019.
(徳島大学機関リポジトリ): ● Metadata: 113420
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.66.185
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31064936; ● Summary page in Scopus @ Elsevier: 2-s2.0-85065772885

(徳島大学機関リポジトリ: 113420, DOI: 10.2152/jmi.66.185, PubMed: 31064936, Elsevier: Scopus) Yoshihito Saijo, Hirotsugu Yamada, Kenya Kusunose, Mika Bando, Susumu Nishio, Yuta Torii, Yukina Hirata, Hiromitsu Seno, Tomomi Matsuura, Takayuki Ise, Takeshi Tobiume, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
A clinical application of preload stress echocardiography for predicting future hemodynamic worsening in patients with early-stage heart failure.,
Echocardiography, Vol.35, No.10, 1587-1595, 2018.

(要約): To improve the prognosis of patients with heart failure, risk stratification in their early stage is important. We assessed whether the change in transmitral flow (TMF) velocity pattern during preload augmentation can predict future hemodynamic worsening in early-stage heart failure patients with impaired relaxation TMF pattern. We designed a prospective cohort study that included 155 consecutive patients with impaired relaxation (IR) pattern at rest. Preload stress echocardiography was achieved using leg-positive pressure (LPP), and changes in TMF pattern during the LPP was observed during baseline echocardiographic examination. The patients whose TMF pattern developed to pseudonormal (PN) pattern throughout the study period were classified into the change to PN group, and patients whose TMF pattern stayed in IR pattern were classified into the stay in IR group. The median follow-up period was 17 months. The average age was 68 ± 11 years old, and 97 patients (63%) were male. Among 155 patients, 27 were classified into the change to PN group. A Cox proportional hazard analysis confirmed that the change in the peak atrial systolic TMF velocity during the LPP (ΔA, hazard ratio = 0.58 per 1SD; 95% CI = 0.39-0.88, P = 0.010) was the powerful independent predictor of change into PN pattern. Kaplan-Meier analysis revealed that the patients with ΔA -7 cm/s had more likely to develop into PN pattern than patients with ΔA > -7 cm/s (P = 0.001). Evaluation of a response in TMF during the LPP might provide an incremental diagnostic value to detect future overt heart failure in patients with early-stage heart failure.
(徳島大学機関リポジトリ): ● Metadata: 112877
(出版サイトへのリンク): ● Publication site (DOI): 10.1111/echo.14098
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30005132; ● Summary page in Scopus @ Elsevier: 2-s2.0-85054773574

(徳島大学機関リポジトリ: 112877, DOI: 10.1111/echo.14098, PubMed: 30005132, Elsevier: Scopus) Kenya Kusunose, Hiromitsu Seno, Hirotsugu Yamada, Susumu Nishio, Yuta Torii, Yukina Hirata, Y Saijo, Takayuki Ise, Koji Yamaguchi, Daiju Fukuda, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Right Ventricular Function and Beneficial Effects of Cardiac Rehabilitation in Patients With Systolic Chronic Heart Failure.,
The Canadian Journal of Cardiology, Vol.34, No.10, 1307-1315, 2018.

(要約): It has been recognized that a comprehensive cardiac rehabilitation (CR) program improves mortality in patients with chronic heart failure. On the other hand, the magnitude of the improvement in exercise capacity after CR differs among individuals. The aim of this study was to assess the echocardiographic determinants of responders to CR using preload stress echocardiography. We prospectively enrolled 58 chronic heart failure patients with reduced left ventricular ejection fraction (aged 62 ± 11 years; 69% male; left ventricular ejection fraction 43% ± 7%) who had received optimized medical treatment in a CR program for 5 months. We performed preload echocardiographic studies using leg positive pressure (LPP) to assess the echocardiographic parameters during preload augmentation. We defined 41 patients as a development cohort to assess the predictive value of echocardiographic variables. Next, we validated results in the remaining 17 patients as a validation cohort. In the development cohort, significant improvement in peak oxygen uptake (VO) (>10%) after CR was observed in 58% patients. In a multivariable logistic regression model, the significant predictor of improvement in exercise capacity was right ventricular (RV) strain during LPP (odds ratio: 3.96 per 1 standard deviation; P = 0.01). An RV strain value of -16% during LPP had a good sensitivity of 0.79 and a specificity of 0.71 to identify patients with improvement in peak VO. In the validation cohort, an optimal cutoff value of RV strain value was the same (area under the curve: 0.77, sensitivity: 0.78, specificity: 0.65). RV strain during LPP may be an echocardiographic parameter for assessing beneficial effects of CR.
(徳島大学機関リポジトリ): ● Metadata: 114204
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.cjca.2018.06.003
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30146462; ● Summary page in Scopus @ Elsevier: 2-s2.0-85052061274

(徳島大学機関リポジトリ: 114204, DOI: 10.1016/j.cjca.2018.06.003, PubMed: 30146462, Elsevier: Scopus) Takeshi Soeki, Tomomi Matsuura, Takeshi Tobiume, Sachiko Bando, Matsumoto Kazuhisa, Hiromi Nagano, Etsuko Uematsu, Kenya Kusunose, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Clinical, Electrocardiographic, and Echocardiographic Parameter Combination Predicts the Onset of Atrial Fibrillation.,
Circulation Journal, Vol.82, No.9, 2253-2258, 2018.

(要約): The ability to identify risk markers for new-onset atrial fibrillation (AF) is critical to the development of preventive strategies, but it remains unknown whether a combination of clinical, electrocardiographic, and echocardiographic parameters predicts the onset of AF. In the present study, we evaluated the predictive value of a combined score that includes these parameters.Methods and Results:We retrospectively studied 1,040 patients without AF who underwent both echocardiography and 24-h Holter electrocardiography between May 2005 and December 2010. During a median follow-up period of 68.4 months (IQR, 49.9-93.3 months), we investigated the incidence of new-onset AF. Of the 1,040 patients, 103 (9.9%) developed AF. Patients who developed AF were older than patients who did not. Total heart beats, premature atrial contraction (PAC) count, maximum RR interval, and frequency of sinus pause quantified on 24-h electrocardiography were associated with new-onset AF. LA diameter (LAD) on echocardiography was also associated with the development of AF. On multivariate Cox analysis, age 58 years, PAC count 80 beats/day, maximum RR interval 1.64 s, and LAD 4.5 cm were independently associated with the development of AF. The incidence rate of new-onset AF significantly increased as the combined score (i.e., the sum of the risk score determined using hazard ratios) increased. A combined score that includes age, PAC count, maximum RR interval, and LAD could help characterize the risk of new-onset AF.
(徳島大学機関リポジトリ): ● Metadata: 113221
(出版サイトへのリンク): ● Publication site (DOI): 10.1253/circj.CJ-17-0758
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29848884; ● Summary page in Scopus @ Elsevier: 2-s2.0-85052204332

(徳島大学機関リポジトリ: 113221, DOI: 10.1253/circj.CJ-17-0758, PubMed: 29848884, Elsevier: Scopus) Kageyuki Oba, Minetaka Maeda, Gulinu Maimaituxun, Satoshi Yamaguchi, Osamu Arasaki, Daiju Fukuda, Shusuke Yagi, Hirata Yukina, Susumu Nishio, Takashi Iwase, Shoichiro Takao, Kenya Kusunose, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Masafumi Harada, Hiroaki Masuzaki, Masataka Sata and Michio Shimabukuro :
Effect of the Epicardial Adipose Tissue Volume on the Prevalence of Paroxysmal and Persistent Atrial Fibrillation.,
Circulation Journal, Vol.82, No.7, 1778-1787, 2018.

(要約): Although increasing evidence suggests that epicardial adipose tissue volume (EATV) is associated with atrial fibrillation (AF), it is controversial whether there is a dose-response relationship of increasing EATV along the continuum of AF. We evaluated the effect of the EATV on the prevalence of paroxysmal AF (PAF) and persistent AF (PeAF) and the relationships with cardiac structure and functional remodeling.Methods and Results:Subjects who underwent multidetector computed tomography (MDCT) coronary angiography because of symptoms suggestive of coronary artery disease were divided into sinus rhythm (SR) (n=112), PAF (n=133), and PeAF (n=71) groups. The EATV index (EATV/body surface area, mL/m) was strongly associated with the prevalence of PAF and PeAF on the model adjusted for known AF risk factors. The effect of the EATV index on the prevalence of PeAF, but not on that of PAF, was modified by the left atrial (LA) dimension, suggesting that extension of the LA dimension is related to EATV expansion in PeAF. The cutoff value of the EATV index for the prevalence was higher in PeAF than in PAF (64 vs. 55 mL/m, P<0.01). The EATV index is associated with the prevalence of PAF and PeAF, and its cutoff values are predictive for PAF and PeAF development independently of other AF risk factors.
(徳島大学機関リポジトリ): ● Metadata: 113224
(出版サイトへのリンク): ● Publication site (DOI): 10.1253/circj.CJ-18-0021
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29806623; ● Summary page in Scopus @ Elsevier: 2-s2.0-85049036945

(徳島大学機関リポジトリ: 113224, DOI: 10.1253/circj.CJ-18-0021, PubMed: 29806623, Elsevier: Scopus) Kenya Kusunose, Y Okushi, Hirotsugu Yamada, Susumu Nishio, Yuta Torii, Yukina Hirata, Y Saijo, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Prognostic Value of Frailty and Diastolic Dysfunction in Elderly Patients.,
Circulation Journal, Vol.82, No.8, 2103-2110, 2018.

(要約): High prevalence of frailty and of diastolic dysfunction (DD) in heart failure and high mortality in frail adults have been noted. We characterized frailty by quantifying differences on echocardiography, and assessed the added prognostic utility of frailty and DD grade in an elderly population. One hundred and ninety-one patients 65 years who had at least 1 cardiovascular risk factor were prospectively recruited for clinically indicated echocardiography at the present institute. Weight loss, exhaustion, and deficits in physical activity, gait speed, and handgrip strength were used to categorize patients as frail (3 features), intermediately frail (1 or 2 features), or non-frail (0 features). DD grade 2 was defined as severe. Frailty was associated with larger left atrial volume, smaller stroke volume, and worse DD grade after adjustment for age. In a period of 14 months, 29 patients (15%) had cardiovascular events. The addition of frailty score and severe DD significantly improved the prognostic power of a model containing male gender (model 1, male gender, χ=6.4; model 2, model 1 plus frailty score, χ=16.7, P=0.004; model 3, model 2 plus severe DD, χ=25.5, P=0.015). Both frailty and DD grade were significantly associated with future cardiovascular events in an elderly population with preserved ejection fraction and 1 risk factor of cardiovascular disease.
(徳島大学機関リポジトリ): ● Metadata: 113222
(出版サイトへのリンク): ● Publication site (DOI): 10.1253/circj.CJ-18-0017
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29709994; ● Summary page in Scopus @ Elsevier: 2-s2.0-85050588123

(徳島大学機関リポジトリ: 113222, DOI: 10.1253/circj.CJ-18-0017, PubMed: 29709994, Elsevier: Scopus) Tomoya Hara, Pham Tran Phuong, Daiju Fukuda, Koji Yamaguchi, Chie Murata, Sachiko Nishimoto, Shusuke Yagi, Kenya Kusunose, Hirotsugu Yamada, Soeki Takeshi, Tetsuzo Wakatsuki, Issei Imoto, Michio Shimabukuro and Masataka Sata :
Protease-Activated Receptor-2 Plays a Critical Role in Vascular Inflammation and Atherosclerosis in Apolipoprotein E-Deficient Mice.,
Circulation, Vol.138, No.16, 1706-1719, 2018.

(要約): -The coagulation system is closely linked with vascular inflammation, although the underlying mechanisms are still obscure. Recent studies show that protease-activated receptor (PAR)-2, a major receptor of activated factor X (FXa), are expressed in both vascular cells and leukocytes, suggesting that PAR-2 may contribute to the pathogenesis of inflammatory diseases. Here we investigated the role of PAR-2 in vascular inflammation and atherogenesis. -We generated apolipoprotein E-deficient ( ) mice lacking systemic PAR-2 expression ( ). mice which lack or express PAR-2 only in bone-marrow (BM) cells were also generated by BM transplantation. Atherosclerotic lesions were investigated after 20 weeks on a western-type diet (WTD) by histological analyses, quantitative RT-PCR, and western blotting. In vitro experiments using BM-derived macrophages were performed to confirm pro-inflammatory roles of PAR-2. The association between plasma FXa level and the severity of coronary atherosclerosis was also examined in humans who underwent coronary intervention. - mice showed reduced atherosclerotic lesions in the aortic arch (<0.05) along with features of stabilized atherosclerotic plaques such as less lipid deposition (<0.05), collagen loss (<0.01), macrophage accumulation (<0.05), and inflammatory molecule expression (<0.05) compared with mice. Systemic PAR2 deletion in mice significantly decreased the expression of inflammatory molecules in the aorta. The results of BM transplantation experiments demonstrated that PAR-2 in hematopoietic cells contributed to atherogenesis in mice. PAR-2 deletion did not alter metabolic parameters. In vitro experiments demonstrated that FXa or a specific peptide agonist of PAR-2 significantly increased expression of inflammatory molecules and lipid uptake in BM-derived macrophages from wild-type mice compared with those from PAR-2-deficient mice. Activation of NF- κB signaling was involved in PAR-2-associated vascular inflammation and macrophage activation. In humans who underwent coronary intervention, plasma FXa level independently correlated with the severity of coronary atherosclerosis as determined by Gensini score (<0.05) and plaque volume (<0.01). -PAR-2 signaling activates macrophages and promotes vascular inflammation, increasing atherosclerosis in mice. This signaling pathway may also participate in atherogenesis in humans.
(徳島大学機関リポジトリ): ● Metadata: 112891
(出版サイトへのリンク): ● Publication site (DOI): 10.1161/CIRCULATIONAHA.118.033544
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29700120; ● Summary page in Scopus @ Elsevier: 2-s2.0-85055611443

(徳島大学機関リポジトリ: 112891, DOI: 10.1161/CIRCULATIONAHA.118.033544, PubMed: 29700120, Elsevier: Scopus) Gulinu Maimaituxun, Michio Shimabukuro, Daiju Fukuda, Shusuke Yagi, Yukina Hirata, Takashi Iwase, Shoichiro Takao, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Takeshi Tobiume, Koji Yamaguchi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Masafumi Harada and Masataka Sata :
Local Thickness of Epicardial Adipose Tissue Surrounding the Left Anterior Descending Artery Is a Simple Predictor of Coronary Artery Disease - New Prediction Model in Combination With Framingham Risk Score.,
Circulation Journal, Vol.82, No.5, 1369-1378, 2018.

(要約): Compared with global cardiac adiposity, the local accumulation of fat surrounding coronary arteries might have a more direct impact on coronary artery disease (CAD). Here, we compared the local epicardial adipose tissue (EAT) thickness and global cardiac adiposity volumes for predicting CAD.Methods and Results:A total of 197 consecutive subjects underwent 320-slice multi-detector computed tomography coronary angiography and were segregated into CAD (1 coronary artery branch stenosis 50%) and non-CAD groups. EAT thickness was measured at the right coronary artery (EAT), the left anterior descending artery (EAT), and the left circumflex artery (EAT). Although EATand EATwere similar between the 2 groups, EATwas larger in the CAD group than in the non-CAD group (5.45±2.16 mm vs. 6.86±2.19 mm, P<0.001). EAT, after correcting for confounding factors, was strongly associated with CAD (r=0.276, P<0.001) and Gensini score (r=0.239, P<0.001). On multiple regression analysis, Framingham risk score combined with EATwas a strong predictor of CAD (adjusted R=0.121; P<0.001). The local fat thickness surrounding the LAD is a simple and useful surrogate marker for estimating the presence, severity, and extent of CAD, independent of classical cardiovascular risk factors.
(徳島大学機関リポジトリ): ● Metadata: 112879
(出版サイトへのリンク): ● Publication site (DOI): 10.1253/circj.CJ-17-1289
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29563352; ● Summary page in Scopus @ Elsevier: 2-s2.0-85045965929

(徳島大学機関リポジトリ: 112879, DOI: 10.1253/circj.CJ-17-1289, PubMed: 29563352, Elsevier: Scopus) 清水郁子, 瀬野弘光, 山口浩司, 楠瀬賢也, 山田博胤, 若槻哲三, 添木武, 佐田政隆, 岩瀬俊, 黒部裕嗣, 北川哲也 :
Calcified Amorphous Tumorに対し腫瘍摘出術を行った一例,
四国医学雑誌, Vol.74, No.1-2, 84, 2018年. Hiromu Yamazaki, Shusuke Yagi, Yuta Torii, Rie Amano, Yasuyuki Oomichi, Teruaki Sangawa, Daiju Fukuda, Muneyuki Kadota, Takayuki Ise, Rie Ueno, Tomoya Hara, Kenya Kusunose, Tomomi Matsuura, Takeshi Tobiume, Koji Yamaguchi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Edoxaban improves acute venous thromboembolism while preserving protein C and protein S levels,
Journal of Cardiology, Vol.71, No.3, 305-309, 2017.

(要約): It is well known that warfarin inhibits the synthesis of vitamin K-dependent anticoagulants, including thrombin, protein C and S, and factor Xa, leading, paradoxically, to an initial hypercoagulable state. Edoxaban, a direct inhibitor of activated factor X is widely used for the treatment of acute venous thromboembolism (VTE). However, the effect of edoxaban on circulating coagulation factors, in patients with acute VTE, remains unknown. We enrolled 57 patients with acute VTE with/without pulmonary embolism treated with edoxaban (n=37) or warfarin (n=20) in a clinical setting. Before treatment and 2 weeks after treatment, we evaluated thrombotic burden using ultrasound or computed tomography angiography. We also evaluated thrombin generation, represented by prothrombin fragment F1+2; thrombus degradation, represented by D-dimer; and levels of anticoagulants, including protein C, protein S, and antithrombin III. Both edoxaban and warfarin treatment improved thrombotic burden and decreased prothrombin fragment F1+2, and D-dimer. Edoxaban treatment preserved protein C and protein S levels. In contrast, warfarin decreased protein C and protein S levels. Neither treatment affected antithrombin III. Edoxaban improves VTE while preserving protein C and protein S levels, thereby indicating that edoxaban improves thrombotic burden while maintaining levels of anticoagulants.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jjcc.2017.09.009
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29100817; ● Summary page in Scopus @ Elsevier: 2-s2.0-85032912457

(DOI: 10.1016/j.jjcc.2017.09.009, PubMed: 29100817, Elsevier: Scopus) Shusuke Yagi, Ken-ichi Aihara, Takeshi Kondo, Kiyoe Kurahashi, Sumiko Yoshida, Itsuro Endo, Daiju Fukuda, Yutaka Nakaya, Kin-Ichiro Suwaki, Takashi Takeji, Toshihiro Wada, Masdan Hotimah Salim, Saori Hama, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Koji Yamaguchi, Takeshi Tobiume, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Munehide Matsuhisa, Michio Shimabukuro, Masashi Akaike and Masataka Sata :
Predictors for the Treatment Effect of Sodium Glucose Co-transporter 2 Inhibitors in Patients with Type 2 Diabetes Mellitus.,
Advances in Therapy, Vol.35, No.1, 124-134, 2017.

(要約): Predictors for the effect of sodium glucose co-transporter 2 (SGLT2) inhibitors at lowering hemoglobin A1c (HbA1c) levels in type 2 diabetes mellitus patients remain unclear. We therefore aimed to elucidate these predictors in type 2 diabetes patients after 3 months of SGLT2 treatment. A total of 302 consecutive type 2 diabetes patients who had been treated with SGLT2 inhibitors as monotherapy or add-on therapy to existing antidiabetic treatments were enrolled retrospectively. After excluding 27 patients whose HbA1c levels could not be evaluated 3 months after treatment, the glucose-lowering effects of SGLT2 inhibitors were assessed in 275 patients by measuring HbA1c levels before and 3 months after treatment. The predictors for changes in HbA1c levels after 3 months of treatment were evaluated. SGLT2 inhibitor treatment for 3 months decreased HbA1c levels from 7.8 ± 1.2% to 7.4 ± 1.0% (p < 0.0001). A multiple regression analysis showed that the independent determinants for SGLT2 inhibitor treatment effect included decreased HbA1c levels after 1 month of treatment, high baseline HbA1c levels, and a high estimated glomerular filtration rate (eGFR). We show that type 2 diabetes patients who received the greatest glucose-lowering effect with SGLT2 inhibitor treatment were those with preserved renal function (high baseline eGFR) and high baseline HbA1c levels. Moreover, SGLT2 inhibitor treatment efficacy could be predicted by the patients' initial response to treatment.
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s12325-017-0639-z
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29185199; ● Summary page in Scopus @ Elsevier: 2-s2.0-85035102977

(DOI: 10.1007/s12325-017-0639-z, PubMed: 29185199, Elsevier: Scopus) Shusuke Yagi, Takeshi Soeki, Ken-Ichi Aihara, Daiju Fukuda, Takayuki Ise, Muneyuki Kadota, Sachiko Bando, Tomomi Matsuura, Takeshi Tobiume, Koji Yamaguchi, Kenya Kusunose, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro, Masashi Akaike and Masataka Sata :
Low Serum Levels of Eicosapentaenoic Acid and Docosahexaenoic Acid are Risk Factors for Cardiogenic Syncope in Patients with Brugada Syndrome,
International Heart Journal, Vol.58, No.5, 720-723, 2017.

(要約): The n-3 polyunsaturated fatty acids (PUFAs), including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have antiarrhythmic effects, possibly via modulation of the cardiac ion channels. Nevertheless, it is unknown whether low serum levels of n-3 PUFAs are risk factors for ventricular fibrillation in patients with Brugada syndrome (BrS). We retrospectively reviewed data from 62 men with BrS and evaluated their serum levels of EPA and DHA, and the risk factors for sudden cardiac death, including a history of cardiogenic syncope. Nineteen patients had a history of cardiogenic syncope, and their EPA and DHA levels were significantly lower than those of the patients without syncope. Multivariate logistic regression analysis revealed that low EPA and DHA levels were associated with the incidence of syncope. The receiver-operator characteristic curve showed the area under the curves of EPA and DHA for history of syncope were 0.84 and 0.72, respectively. In conclusion, low levels of EPA and DHA are risk factors for cardiogenic syncope in patients with BrS, which suggests that n-3 PUFAs play important roles in preventing ventricular fibrillation in BrS.
(キーワード): Adult / Aged / Aged, 80 and over / Biomarkers / Brugada Syndrome / Chromatography, Gas / Docosahexaenoic Acids / Eicosapentaenoic Acid / Electrocardiography / Follow-Up Studies / Humans / Incidence / 日本 (Japan) / Male / Middle Aged / Prevalence / ROC Curve / Retrospective Studies / Risk Assessment / Risk Factors / Syncope / Young Adult
(出版サイトへのリンク): ● Publication site (DOI): 10.1536/ihj.16-278
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28966307; ● CiNii @ 国立情報学研究所 (CRID): 1390282680202467328; ● Summary page in Scopus @ Elsevier: 2-s2.0-85032215381

(DOI: 10.1536/ihj.16-278, PubMed: 28966307, CiNii: 1390282680202467328, Elsevier: Scopus) Yuriko Takagawa, Shusuke Yagi, Takayuki Ise, Ayumi Ishii, Koji Nishikawa, Daiju Fukuda, Kenya Kusunose, Tomomi Matsuura, Takeshi Tobiume, Koji Yamaguchi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Michio Shimabukuro, Shinsuke Katoh, Ken-ichi Aihara, Masashi Akaike and Masataka Sata :
Improved Exercise Capacity After Cardiac Rehabilitation Is Associated with Reduced Visceral Fat in Patients with Chronic Heart Failure.,
International Heart Journal, Vol.58, No.5, 746-751, 2017.

(要約): Participation in a comprehensive cardiac rehabilitation (CR) program has been shown to reduce mortality and improve exercise capacity and symptoms in patients with chronic heart failure (CHF). Reduced exercise capacity leads to a concomitant reduction of skeletal muscle mass and accumulation of body fat. However, it is currently unknown whether CR reduces visceral adipose tissue (VAT) and/or subcutaneous abdominal adipose tissue (SAT) in patients with CHF. In addition, the body composition associated with improved exercise capacity after CR in patients with CHF has not been previously studied. Nineteen CHF patients who were categorized as NYHA functional class II or III and had received optimal medical treatment including a CR program for 5 months were enrolled in this study. The CR program significantly increased peak VO and reduced B-type natriuretic peptide. In addition, fat and body composition analysis showed reductions in the visceral fat tissue (VAT) area, subcutaneous abdominal adipose tissue (SAT) area, body weight, and total fat weight after CR. There were no changes in total water weight and total muscle weight. Single regression analysis revealed that the amelioration of reduced exercise capacity seen after CR is associated with reduced VAT area but not with SAT area or body weight. In conclusion, CR reduces VAT and improves exercise capacity in patients with CHF. This suggests that reducing VAT is important for CR to be most effective in the treatment of CHF.
(キーワード): Body Composition / Cardiac Rehabilitation / Exercise Tolerance / Female / Follow-Up Studies / 心不全 (heart failure) / Humans / Intra-Abdominal Fat / Male / Middle Aged / 肥満症 (obesity) / 酸素消費 (oxygen consumption) / Prognosis / Retrospective Studies / Weight Loss
(徳島大学機関リポジトリ): ● Metadata: 110111
(出版サイトへのリンク): ● Publication site (DOI): 10.1536/ihj.16-454
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28966316; ● Summary page in Scopus @ Elsevier: 2-s2.0-85032221042

(徳島大学機関リポジトリ: 110111, DOI: 10.1536/ihj.16-454, PubMed: 28966316, Elsevier: Scopus) Shusuke Yagi, Yukina Hirata, Takayuki Ise, Kenya Kusunose, Hirotsugu Yamada, Daiju Fukuda, Salim Masdan Hotimah, G Maimaituxun, Susumu Nishio, Yuriko Takagawa, Saori Hama, Tomomi Matsuura, Koji Yamaguchi, Takeshi Tobiume, Takeshi Soeki, Tetsuzo Wakatsuki, Ken-ichi Aihara, Masashi Akaike, Michio Shimabukuro and Masataka Sata :
Canagliflozin reduces epicardial fat in patients with type 2 diabetes mellitus.,
Diabetology & Metabolic Syndrome, Vol.9, 78, 2017.

(要約): It is unknown whether canagliflozin, a selective sodium glucose co-transporter 2 inhibitor, reduces epicardial adipose tissue (EAT) thickness, which is associated with insulin resistance and is a risk factor for coronary artery disease. We administered 100 mg of canagliflozin for 6 months to 13 patients with type 2 diabetes mellitus. We evaluated glycemic control, visceral adipose tissue (VAT) area and subcutaneous adipose tissue (SAT) area, and skeletal muscle mass by using impedance methods, and EAT thickness by using echocardiography. Canagliflozin treatment for 6 months decreased hemoglobin A1c level from 7.1 ± 0.5% to 6.7 ± 0.6% (P < 0.05) and decreased EAT thickness from 9.3 ± 2.5 to 7.3 ± 2.0 mm (P < 0.001), along with a trend of decreasing VAT and SAT area. No association was found between any of these changes. Canagliflozin reduced EAT thickness in patients with type 2 diabetes mellitus independent of its effect on lowering blood glucose, suggesting that canagliflozin may have an effect in preventing cardiovascular events in these patients (UMIN000021327).
(徳島大学機関リポジトリ): ● Metadata: 114544
(出版サイトへのリンク): ● Publication site (DOI): 10.1186/s13098-017-0275-4
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29034006; ● Summary page in Scopus @ Elsevier: 2-s2.0-85030465923

(徳島大学機関リポジトリ: 114544, DOI: 10.1186/s13098-017-0275-4, PubMed: 29034006, Elsevier: Scopus) Kenya Kusunose, Hirotsugu Yamada, Susumu Nishio, Yuta Torii, Yukina Hirata, Hiromitsu Seno, Yoshihito Saijo, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Preload Stress Echocardiography Predicts Outcomes in Patients With Preserved Ejection FractionandLow-GradientAorticStenosis,
Circulation. Cardiovascular Imaging, Vol.10, No.10, 2017.

(要約): The projected aortic valve area (AVA) at a normal transvalvular flow rate using dobutamine is helpful to determine the actual severity of aortic stenosis (AS) and to predict risk of adverse events in low-gradient AS cases with unclear surgical indication. Our study aimed to identify the independent and incremental value of preload stress echocardiography-derived AVA to predict outcomes in patients with preserved ejection fraction and low-gradient AS. We prospectively performed echocardiographic studies in 79 patients with low-gradient AS (age, 77±7 years; 30% men) with preload stress echocardiography using leg positive pressure. AVA was calculated using AVA and transvalvular flow rate at baseline and during leg positive pressure. The primary end point was the decision for aortic valve surgery or cardiac death. During a median period of 19 months, 23 patients had the decision for aortic valve surgery, and none died during follow-up. In a stepwise multivariable analysis, indexed AVA (AVAi; hazard ratio, 2.00 per 0.1 cm/m decrease; 95% confidence interval, 1.36-2.96; <0.001) was associated with the primary end point. Using a receiver operating characteristic curve analysis, the best cutoff value of AVAi for predicting cardiac events was <0.72 cm/m. By incorporating AVAi into AVAi at baseline, continuous net reclassification index for cardiac events was 0.48 (=0.04). In patients with low-gradient AS, indexed AVA derived from preload stress echocardiography can be useful to predict risk of adverse events. The present article should be considered as a proof of concept study, and we think that larger multicenter studies are warranted.
(キーワード): Aged / Aged, 80 and over / Aortic Valve / Aortic Valve Stenosis / Area Under Curve / Disease Progression / Disease-Free Survival / Echocardiography, Stress / Female / Humans / Kaplan-Meier Estimate / Male / Models, Cardiovascular / Predictive Value of Tests / Prospective Studies / ROC Curve / Severity of Illness Index / Stroke Volume / Time Factors / Ventricular Function, Left
(出版サイトへのリンク): ● Publication site (DOI): 10.1161/CIRCIMAGING.117.006690
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29021259; ● Summary page in Scopus @ Elsevier: 2-s2.0-85031850278

(DOI: 10.1161/CIRCIMAGING.117.006690, PubMed: 29021259, Elsevier: Scopus) Susumu Nishio, Kenya Kusunose, Hirotsugu Yamada, Yukina Hirata, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Echocardiographic Epicardial Adipose Tissue Thickness Is Associated with Symptomatic Coronary Vasospasm during Provocative Testing.,
Journal of the American Society of Echocardiography, Vol.30, No.10, 1021-1027, 2017.

(要約): Epicardial adipose tissue (EAT) is the ectopic visceral fat surrounding the heart, which plays an important role in atherosclerosis of the coronary arteries via endothelial damage. Several studies have also suggested that vasospasm with angina (VSA) causes endothelial dysfunction in the coronary arteries. The aim of this study was to evaluate the thickness of EAT in the anterior interventricular groove (EAT-AIG) using echocardiography in patients who had no obstructive coronary artery disease and were suspected of having VSA. Sixty-five patients who underwent intracoronary acetylcholine provocation testing for clinical indications were prospectively enrolled. VSA was diagnosed by coronary artery stenosis increase of >90% and the presentation of chest pain with ischemic changes on electrocardiography. Subjects were divided into two groups, with and without significant coronary spasm (VSA group, 30 patients; non-VSA group, 35 patients), consistent with acetylcholine provocation testing. EAT-AIG thickness was significantly greater in the VSA group than in the non-VSA group (8.2 2.7 vs 6.1 2.5 mm, P = .002). By receiver operating characteristic analysis, EAT-AIG thickness had a high C statistic (area under the curve = 0.81, P < .001) after adjustment for conventional risk factors (smoking, diabetes mellitus, and dyslipidemia). EAT-AIG thickness had incremental diagnostic value over other conventional risk factors (area under the curve = 0.81 vs 0.64, P for comparison = .020). EAT-AIG thickness, which is noninvasively and easily measured using transthoracic echocardiography, can be one of multiple clinical variables associated with VSA.
(徳島大学機関リポジトリ): ● Metadata: 110928
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.echo.2017.06.024
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28843368; ● Search Scopus @ Elsevier (PMID): 28843368; ● Search Scopus @ Elsevier (DOI): 10.1016/j.echo.2017.06.024

(徳島大学機関リポジトリ: 110928, DOI: 10.1016/j.echo.2017.06.024, PubMed: 28843368) Kenya Kusunose, Hirotsugu Yamada, Susumu Nishio, Yukina Hirata, Hiromitsu Seno, Y Saijo, Takayuki Ise, Takeshi Tobiume, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Echocardiographic Predictors for Worsening of Six-Minute Walk Distances in Patients With Systemic Sclerosis (Scleroderma),
The American Journal of Cardiology, Vol.120, No.2, 315-321, 2017.

(要約): Change in 6-minute walk distance (6MWD) has been used as a clinical marker in pulmonary hypertension. Determinants and worsening of 6MWD remain a matter of debate because nonpulmonary factors have an impact on the 6MWD. We hypothesized that future reduction of 6MWD in patients with systemic sclerosis (SSc) was more closely associated with cardiac dysfunction. We prospectively performed standard clinical and echocardiographic evaluations in SSc patients with the 6-minute walk test at enrollment. Features associated with the 6MWD were sought in a multiple linear regression analysis and compared using standardized . Worsening of the 6MWD was defined as a 15% reduction and served as the primary outcome. Eighty-one patients were included. In the multivariate analysis, baseline 6MWD was related to SSc severity score ( = -0.250, p = 0.024), left atrial volume index ( = -0.222, p = 0.046), right ventricular fractional area change ( = 0.252, p = 0.025), and the ratio of mean pulmonary artery pressure and cardiac output ( = -0.31, p = 0.002). During follow-up, 20 patients reached the primary outcome. In sequential Cox models, a model based on right ventricular fractional area change at baseline (chi-square 4.8) was improved by left atrial volume index (chi-square 10.3, p = 0.007). In conclusion, determinants and worsening of 6MWD are explained by cardiac factors. When using the 6MWD as a clinical marker in pulmonary hypertension patients, their left ventricular diastolic function and right ventricular systolic function should be taken into consideration.
(キーワード): Diastole / Disease Progression / Echocardiography, Doppler / Female / Follow-Up Studies / Humans / Hypertension, Pulmonary / Male / Middle Aged / Predictive Value of Tests / Prospective Studies / Scleroderma, Systemic / Stroke Volume / Systole / Time Factors / Ventricular Function, Left / Ventricular Function, Right / Walking
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.amjcard.2017.04.024
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28532772; ● Search Scopus @ Elsevier (PMID): 28532772; ● Search Scopus @ Elsevier (DOI): 10.1016/j.amjcard.2017.04.024

(DOI: 10.1016/j.amjcard.2017.04.024, PubMed: 28532772) Kenya Kusunose, Hirotsugu Yamada, Susumu Nishio, Ayumi Ishii, Yukina Hirata, Hiromitsu Seno, Yoshihito Saijo, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
RV Myocardial Strain During Pre-Load Augmentation Is Associated With Exercise Capacity in Patients With Chronic HF,
JACC. Cardiovascular Imaging, Vol.10, No.10, 1240-1249, 2017.

(要約): The aim of this study was to assess the relationship between right ventricular (RV) function during pre-load augmentation and exercise tolerance. Peak oxygen uptake (VO2) is a strong predictor of mortality in chronic heart failure. Cardiac function during pre-load augmentation is an important part of the phenomenon in the evaluation of exercise capacity. We prospectively performed echocardiographic studies in 68 chronic heart failure patients with cardiopulmonary exercise testing (mean age 60 ± 12 years; 69% male). After resting evaluations, echocardiographic parameters were repeated during leg positive pressure (LPP). Exercise capacity was assessed by peak VO2 in all patients (left ventricular ejection fraction: 43 ± 15%). Patients with severely reduced exercise capacity (peak VO2 <14 ml/kg/min) had significantly lower stroke volume index, left ventricular global longitudinal strain and RV strain and higher filling pressure (E/e' and pulmonary arterial systolic pressure) than the remainder. Stroke volume index ( = 0.49), global longitudinal strain ( = -0.61), E/e' ( = -0.32), pulmonary arterial systolic pressure ( = -0.57), and RV strain ( = -0.66) during LPP were independently correlated to peak VO2 (all p < 0.01). RV strain during LPP was the most powerful predictor in identifying patients with severely reduced exercise capacity (cut off value: -17%; sensitivity: 81%; specificity: 88%; areas under the curve: 0.88; p < 0.001) compared with other variables including resting parameters. RV strain during pre-load augmentation correlated independently to peak VO2 and was a powerful predictor in identifying patients with severely reduced exercise capacity.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jcmg.2017.03.022
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28734918; ● Summary page in Scopus @ Elsevier: 2-s2.0-85025467938

(DOI: 10.1016/j.jcmg.2017.03.022, PubMed: 28734918, Elsevier: Scopus) Akira Takashima, Tatsuro Ogata, Hirotsugu Yamada, Tetsuzo Wakatsuki and Masataka Sata :
Intracardiac echocardiography-guided biopsy of a lipomatous cardiac tumor arising from the interatrial septum.,
Circulation Journal, Vol.81, No.10, 1553-1555, 2017.

(出版サイトへのリンク): ● Publication site (DOI): 10.1253/circj.CJ-17-0138
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28367861; ● Summary page in Scopus @ Elsevier: 2-s2.0-85030104785

(DOI: 10.1253/circj.CJ-17-0138, PubMed: 28367861, Elsevier: Scopus) S Bando, Takeshi Soeki, Tomomi Matsuura, Takeshi Tobiume, Takayuki Ise, Kenya Kusunose, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro, Naoki Muguruma, Tetsuji Takayama, I Kishimoto, Kenji Kangawa and Masataka Sata :
Plasma brain natriuretic peptide levels are elevated in patients with cancer,
PLoS ONE, Vol.12, No.6, e0178607, 2017.

(要約): Natriuretic peptides have been proposed as biomarkers of cardiovascular disease, especially heart failure. Brain natriuretic peptide (BNP) has also been shown to be upregulated at the transcriptional and translational levels by pro-inflammatory cytokines in cardiac myocytes. Although we often measure plasma BNP levels in cancer patients, it remains unknown whether cancer-related inflammation affects the plasma BNP levels. We investigated the relationship between the BNP and human cancers. We retrospectively studied 2,923 patients in whom the plasma BNP levels and serum C-reactive protein (CRP) were measured and echocardiography was performed. Patients with clinically evident heart failure (NYHA II or higher), heart disease requiring medical treatment or surgery, renal dysfunction, and inflammatory disease were excluded. There were 234 patients in the final analysis. Blood sampling was performed before surgery and chemotherapy. In addition, we evaluated the relationship between the inflammation and plasma BNP levels in mouse models of colon cancer. Of the 234 patients, 80 were diagnosed with cancer. Both the plasma BNP and serum CRP levels were significantly higher in cancer patients than those without. There were no significant differences in the echocardiographic parameters. There was a significant positive correlation between the plasma BNP and serum CRP levels in cancer patients (r = 0.360, P<0.01) but not in those without. In cancer patients, only the CRP correlated with the BNP independent of the age, creatinine level, hypertension, and body mass index. In addition, in nude mice with subcutaneous colon cancer, the plasma BNP level was elevated compared with that in non-cancer mice, and there was a significant relationship between the plasma BNP and serum levels of the inflammatory markers. In cancer patients, as well as colon cancer model mice, the plasma BNP levels were elevated, possibly due to cancer-related inflammation. The effect of cancer on the BNP levels should be considered when using BNP as an indicator of heart failure in cancer patients.
(徳島大学機関リポジトリ): ● Metadata: 112318
(出版サイトへのリンク): ● Publication site (DOI): 10.1371/journal.pone.0178607
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28570595; ● Search Scopus @ Elsevier (PMID): 28570595; ● Search Scopus @ Elsevier (DOI): 10.1371/journal.pone.0178607

(徳島大学機関リポジトリ: 112318, DOI: 10.1371/journal.pone.0178607, PubMed: 28570595) Kenya Kusunose, Yuta Torii, Hirotsugu Yamada, Susumu Nishio, Yukina Hirata, Hiromitsu Seno, Yoshihito Saijo, Takayuki Ise, Koji Yamaguchi, Takeshi Tobiume, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Clinical Utility of Longitudinal Strain to Predict Functional Recovery in Patients With Tachyarrhythmia and Reduced LVEF.,
JACC. Cardiovascular Imaging, Vol.10, No.2, 118-126, 2017.

(要約): Objectives: The aim of this study was to assess the time course of presumptive TIC and the predictors of LV functional recovery in such patients.Background: Tachycardia-induced cardiomyopathy (TIC) is a potentially reversible cardiomyopathy with effective treatment of the tachyarrhythmia. However, cases without improvement of left ventricular (LV) systolic function were found occasionally. The diagnosis of TIC can be challenging, and the role of echocardiographic imaging in the prediction of LV functional recovery is limited.Methods: LV segmental longitudinal strains (LS) were evaluated by 2-dimensional speckle tracking in 71 consecutive patients (65±16 years; 61% men) with tachyarrhythmia and reduced LV ejection fraction (EF) without any other known cardiovascular disease, and 30 age and gender matched control subjects. Relative apical LS ratio (RALSR) was defined using the equation: average apical LS / (average basal LS + average mid LS) as a marker of strain distribution.Results: Compared to control subjects, patients with tachyarrhythmia had significantly lower global LS. Improvement in LVEF within 6 months after treatment of index arrhythmia was observed in 41 patients, and LVEF did not improve in 30 patients. In univariate analysis, lower LVEF at baseline (hazard ratio: HR: 0.59 per 1SD, p=0.04) and higher RALSR (HR: 11.2 per 1SD, p <0.001) were associated with no recovery in LVEF during follow-up. In a multivariate logistic regression model, the significant predictor of LV systolic functional recovery was RALSR (HR: 22.9 per 1SD, p=0.001). A RALSR of 0.61 was sensitive (71%) and specific (90%) in differentiating LV systolic functional recovery (area under the curve: 0.88).Conclusions: The RALSR was associated with LV systolic functional recovery. This information might be useful for clinical evaluation and follow-up in patients with reduced LVEF.
(キーワード): tachycardia induced cardiomyopathy / strain imaging / functional recovery
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jcmg.2016.03.019
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27665160; ● Summary page in Scopus @ Elsevier: 2-s2.0-84994494325

(DOI: 10.1016/j.jcmg.2016.03.019, PubMed: 27665160, Elsevier: Scopus) A Takashima, Shusuke Yagi, Koji Yamaguchi, S Watanabe, N Yamamoto, H Ito, M Kadota, T Hara, H Yamazaki, Takayuki Ise, Kenya Kusunose, Takeshi Tobiume, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Purulent pericarditis accompanying pericardial abscess induced by nocardia in an immunocompromised patient.,
Circulation Journal, Vol.80, No.11, 2409-2411, 2016.

(キーワード): Abscess / Aged, 80 and over / Echocardiography / Female / Humans / Immunocompromised Host / Nocardia / Nocardia Infections / Pericarditis / Pericardium / Tomography, X-Ray Computed
(出版サイトへのリンク): ● Publication site (DOI): 10.1253/circj.CJ-16-0531
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27628220; ● Summary page in Scopus @ Elsevier: 2-s2.0-84992462594

(DOI: 10.1253/circj.CJ-16-0531, PubMed: 27628220, Elsevier: Scopus) A Takashima, Daiju Fukuda, K Tanaka, Y Higashikuni, Y Hirata, S Nishimoto, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Yutaka Taketani, Michio Shimabukuro and Masataka Sata :
Combination of n-3 polyunsaturated fatty acids reduces atherogenesis in apolipoprotein E-deficient mice by inhibiting macrophage activation.,
Atherosclerosis, Vol.254, 142-150, 2016.

(要約): BACKGROUND AND AIMS: Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are major components of n-3 polyunsaturated fatty acids (n-3 PUFAs) which inhibit atherogenesis, although few studies have examined the effects of the combination of EPA and DHA on atherogenesis. The aim of this study was to investigate whether DHA has additional anti-atherosclerotic effects when combined with EPA.METHODS: Male 8-week-old apolipoprotein E-deficient (Apoe-/-) mice were fed a western-type diet supplemented with different amounts of EPA and DHA; EPA (2.5%, w/w), low-dose EPA + DHA (2.5%, w/w), or high-dose EPA + DHA (5%, w/w) for 20 weeks. The control group was fed a western-type diet containing no n-3 PUFA. Histological and gene expression analysis were performed in atherosclerotic lesions in the aorta. To address the mechanisms, RAW264.7 cells were used.RESULTS: All n-3 PUFA treatments significantly attenuated the development and destabilization of atherosclerotic plaques compared with the control. The anti-atherosclerotic effects were enhanced in the high-dose EPA + DHA group (p < 0.001), whereas the pure EPA group and low-dose EPA + DHA group showed similar results. EPA and DHA additively attenuated the expression of inflammatory molecules in RAW264.7 cells stimulated with LPS. DHA or EPA + DHA suppressed LPS-induced toll-like receptor 4 (TLR4) expression in lipid rafts on RAW264.7 cells (p < 0.05). Lipid raft disruption by methyl--cyclodextrin suppressed mRNA expression of inflammatory molecules in LPS-stimulated macrophages.CONCLUSION: n-3 PUFAs suppressed atherogenesis. DHA combined with EPA had additional anti-inflammatory effects and inhibited atherogenesis in Apoe-/- mice. The reduction of TLR4 expression in lipid rafts in macrophages by DHA might be involved in this mechanism, at least partially.
(キーワード): Atherosclerosis / Inflammation / Lipid raft / Macrophage / Toll-like receptor 4 / n-3 poly unsaturated fatty acid
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.atherosclerosis.2016.10.002
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27744130; ● Summary page in Scopus @ Elsevier: 2-s2.0-84991678518

(DOI: 10.1016/j.atherosclerosis.2016.10.002, PubMed: 27744130, Elsevier: Scopus) 鳥居裕太, 西尾進, 玉井佑里恵, 山崎宙, 髙尾正一郎, 楠瀬賢也, 山口浩司, 若槻哲三, 山田博胤, 佐田政隆 :
解剖学的異常を認めない膝窩動脈捕捉症候群の1例,
超音波検査技術, Vol.41, No.5, 513-520, 2016年.

(出版サイトへのリンク): ● Publication site (DOI): 10.11272/jss.41.513
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390001205281332224; ● Search Scopus @ Elsevier (DOI): 10.11272/jss.41.513

(DOI: 10.11272/jss.41.513, CiNii: 1390001205281332224) M Kadota, Takayuki Ise, Shusuke Yagi, Takashi Iwase, Masashi Akaike, R Ueno, Y Kawabata, T Hara, K Ogasawara, Mika Bando, S Bando, Tomomi Matsuura, Koji Yamaguchi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Response prediction and influence of tolvaptan in chronic heart failure patients considering the interaction of the renin-angiotensin-aldosterone system and arginine vasopressin.,
International Heart Journal, Vol.57, No.4, 461-465, 2016.

(要約): The renin-angiotensin-aldosterone system (RAAS) and arginine vasopressin (AVP) regulate body fluids. Although conventional diuretics have been used for treating heart failure, they activate RAAS and exacerbate renal function. Tolvaptan, a newly developed vasopressin-2 receptor antagonist, elicits aquaresis and improves volume overload in heart failure patients, however, the predictors of tolvaptan effectiveness and the influence on the RAAS and renal function according to tolvaptan therapy are not established. We evaluated 26 chronic heart failure patients receiving therapy with 15 mg/day tolvaptan and examined their laboratory and urinary data before and after tolvaptan therapy. A response to tolvaptan was defined as a body weight decrease by more than 2 kg in a week and a urine volume increase by 500 mL/ day compared with that before tolvaptan administration. Body weight, urine volume, and brain natriuretic peptide levels significantly improved (P < 0.05), without any worsening of renal function represented by serum creatinine, sodium, and potassium. Moreover, no significant changes were observed in the plasma renin activity and plasma aldosterone concentration (PAC). In the responder group, urine osmolality before tolvaptan administration was significantly higher (P < 0.05) but declined significantly after tolvaptan administration (P < 0.05). The AVP/PAC ratio before administration was positively correlated with the efficacy of tolvaptan. Tolvaptan treatment could prevent RAAS activation in chronic heart failure patients. Moreover, monitoring the AVP/PAC ratio may be useful in predicting the tolvaptan response.
(キーワード): Adult / Aged / Aged, 80 and over / Antidiuretic Hormone Receptor Antagonists / Arginine Vasopressin / Benzazepines / Body Mass Index / Female / Heart Failure / Humans / Male / Middle Aged / Prospective Studies / Renin-Angiotensin System / Treatment Outcome
(徳島大学機関リポジトリ): ● Metadata: 109694
(出版サイトへのリンク): ● Publication site (DOI): 10.1536/ihj.15-491
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27357439; ● Summary page in Scopus @ Elsevier: 2-s2.0-84979587993

(徳島大学機関リポジトリ: 109694, DOI: 10.1536/ihj.15-491, PubMed: 27357439, Elsevier: Scopus) Takeshi Soeki, Tomomi Matsuura, Sachiko Bando, Takeshi Tobiume, Etsuko Uematsu, Takayuki Ise, Kenya Kusunose, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Relationship between local production of microRNA-328 and atrial substrate remodeling in atrial fibrillation.,
Journal of Cardiology, Vol.68, No.6, 472-477, 2016.

(要約): BACKGROUND: The underlying mechanism of atrial substrate remodeling in atrial fibrillation (AF) remains unknown. In this study, we investigated whether local and systemic levels of microRNA (miR) might be associated with the presence of AF and with left atrial (LA) substrate properties.METHODS: Blood from the periphery, pulmonary vein (PV), and left atrial appendage (LAA) was sampled from 30 patients with AF undergoing PV isolation, and from 10 control subjects with Wolff-Parkinson-White syndrome and without AF. We measured peripheral, PV, and LAA plasma levels of miR-1, -26, -133a, -328, and -590 by reverse transcription-polymerase chain reaction. LA global contact mapping during sinus rhythm was performed before PV isolation.RESULTS: Plasma levels of miR-328 were higher in patients with AF than in control subjects. Plasma miR-328 levels were significantly higher in the LAA than in the periphery and PV in patients with AF, but not in control subjects. Plasma miR-1 levels were also higher in the LAA than in the PV in AF patients. Interestingly, LAA plasma levels of miR-328 showed a positive correlation with the LA voltage zone index (area with voltage <0.5mV divided by total LA surface area) and a weak correlation with LA volume.CONCLUSION: Local production of miR-328 in the left atrium may be involved in the process of atrial remodeling in patients with AF.
(キーワード): Atrial fibrillation / Left atrium / MicroRNA / Remodeling / Substrate
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jjcc.2015.12.007
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26987792; ● Summary page in Scopus @ Elsevier: 2-s2.0-84960969355

(DOI: 10.1016/j.jjcc.2015.12.007, PubMed: 26987792, Elsevier: Scopus) Toshiyuki Niki, Tetsuzo Wakatsuki, Koji Yamaguchi, Yoshio Taketani, Hiroyasu Oeduka, Kenya Kusunose, Takayuki Ise, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Effects of the addition of eicosapentaenoic acid to strong statin therapy on inflammatory cytokines and coronary plaque components assessed by integrated backscatter intravascular ultrasound.,
Circulation Journal, Vol.80, No.2, 450-460, 2016.

(要約): BACKGROUND: The effects of eicosapentaenoic acid (EPA) on coronary artery disease have been previously reported; however, those of the addition of EPA to strong statins on coronary plaque components and local inflammatory cytokines are not known.METHODSANDRESULTS: A total of 95 patients who had been treated with strong statin for at least 6 months were randomized into 2 groups: an EPA group (additional treatment with EPA at 1,800 mg/day, n=48) or a control group (no additional treatment, n=47), for 6 months. The tissue characteristics of target coronary plaque in each patient were analyzed using IB-IVUS before and after treatment. We also measured plasma levels of inflammatory cytokines sampled in the coronary sinus (CS) and peripheral vein.A significant reduction in lipid volume (18.5±1.3 to 15.0±1.5 mm(3), P=0.007) and a significant increase in fibrous volume (22.9±0.8 to 25.6±1.1 mm(3), P=0.01) were observed in IB-IVUS image analyses in the EPA group, but no significant changes in the plaque components in the control group. CS levels of pentraxin 3 and monocyte chemoattractant protein-1 were lower after than before treatment with EPA (3.3±2.1 to 2.6±1.2 ng/ml, 120.4±26.2 to 110.2±26.8 pg/ml, P=0.015 and P=0.008, respectively); however, there were no significant changes in those inflammatory cytokines between pre- and post-treatment in the control group.CONCLUSIONS: The addition of EPA was associated with reduced lipid volume in coronary plaques and decreased inflammatory cytokines. (Circ J 2016; 80: 450-460).
(キーワード): Coronary plaque / Eicosapentaenoic acid / Inflammatory cytokines / Integrated backscatter intravascular ultrasound / Strong statins
(徳島大学機関リポジトリ): ● Metadata: 109653
(出版サイトへのリンク): ● Publication site (DOI): 10.1253/circj.CJ-15-0813
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26667367; ● Summary page in Scopus @ Elsevier: 2-s2.0-84955453337

(徳島大学機関リポジトリ: 109653, DOI: 10.1253/circj.CJ-15-0813, PubMed: 26667367, Elsevier: Scopus) Akira Takashima, Shusuke Yagi, Koji Yamaguchi, Eri Takagi, Tamotsu Kanbara, Hirohisa Ogawa, Takayuki Ise, Kenya Kusunose, Takeshi Tobiume, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Tetsuya Kitagawa and Masataka Sata :
Vegetation in the coronary sinus that concealed the presence of a coronary arteriovenous fistula in a patient with infectious endocarditis.,
International Journal of Cardiology, Vol.207, 266-268, 2016.

(キーワード): Coronary sinus / Fistula / Infectious endocarditis / Vegetation
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.ijcard.2016.01.057
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26808990; ● Summary page in Scopus @ Elsevier: 2-s2.0-84958019532

(DOI: 10.1016/j.ijcard.2016.01.057, PubMed: 26808990, Elsevier: Scopus) Shusuke Yagi, Ken-ichi Aihara, Daiju Fukuda, Akira Takashima, Mika Bando, Tomoya Hara, Sachiko Nishimoto, Takayuki Ise, Kenya Kusunose, Koji Yamaguchi, Takeshi Tobiume, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Michio Shimabukuro, Masashi Akaike and Masataka Sata :
Reduced ratio of eicosapentaenoic acid and docosahexaenoic acid to arachidonic acid is associated with early onset of acute coronary syndrome.,
Nutrition Journal, Vol.14, No.1, 111, 2015.

(要約): BACKGROUND: The hospitalization rate for acute coronary syndrome (ACS) for people aged 50 has remained stable over the past decade. Increased serum levels of n-3 polyunsaturated fatty acids (PUFAs), such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are associated with a decreased incidence of cardiovascular events and mortality in older patients; however, it is currently unknown whether reduced serum levels of n-3 PUFAs is also a risk factor for ACS in patients aged 50 years.METHODS AND RESULTS: We retrospectively reviewed 102 (male/ female 73/29) Japanese ACS patients whose serum levels of EPA/arachidonic acid (AA) and DHA/AA were evaluated on admission. The EPA/AA ratio was the lowest in patients aged 50 compared to patients aged 51-74 and 75. Pearson correlation analysis showed that early ACS onset was associated with low EPA/AA and DHA/AA ratios, and multiple regression analysis determined that decreased ratios of EPA/AA and DHA/AA, and male sex, current smoker status, increased body mass index and triglyceride levels, independently correlated with early ACS onset. Conversely, low-density and high-density lipoproteins, glycated hemoglobin, and hypertension did not correlate with early ACS onset. Subgroup analyses of male patients revealed that decreased ratios of EPA/AA and DHA/AA independently correlated with early ACS onset.CONCLUSION: Decreased EPA/AA and DHA/AA ratios may be risk factors for early onset of ACS, suggesting that reduced EPA/AA and DHA/AA may represent targets for preventing ACS in Japanese young people.
(出版サイトへのリンク): ● Publication site (DOI): 10.1186/s12937-015-0102-4
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26514181; ● Summary page in Scopus @ Elsevier: 2-s2.0-84945959581

(DOI: 10.1186/s12937-015-0102-4, PubMed: 26514181, Elsevier: Scopus) S Bando, Daiju Fukuda, Takeshi Soeki, S Nishimoto, E Uematsu, Tomomi Matsuura, Takayuki Ise, Takeshi Tobiume, Koji Yamaguchi, Shusuke Yagi, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Expression of NLRP3 in subcutaneous adipose tissue is associated with coronary atherosclerosis.,
Atherosclerosis, Vol.242, No.2, 407-414, 2015.

(要約): ObjectivesThe promotion of adipose tissue inflammation by lifestyle-related diseases such as obesity and diabetes accelerates atherogenesis; however, the underlying mechanisms remain incompletely understood. Nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3 (NLRP3) inflammasome contributes to chronic inflammation in adipose tissue. Here, we investigated the link between NLRP3 expression in subcutaneous adipose tissue (SAT) and the severity of coronary atherosclerosis.Methods and resultsSAT was obtained from 72 patients who underwent heart device implantation and coronary angiography. Expression of NLRP3 inflammasome-related molecules (NLRP3, IL-1 and IL-18) in SAT were evaluated by quantitative RT-PCR. Laboratory markers related to lifestyle-related diseases were measured. Patients with obesity, dyslipidemia (P < 0.05, respectively), diabetes or hyperuricemia (P < 0.01, respectively) had significantly higher expression of NLRP3. Multivariate analysis demonstrated that body mass index and serum level of uric acid were predictors of NLRP3 expression in SAT. The expression of NLRP3 in SAT correlated negatively with serum adiponectin level (r = 0.23, P < 0.05). Patients with coronary artery disease showed higher NLRP3 expression than patients without significant stenosis (P < 0.01). Furthermore, the expression of NLRP3 in SAT correlated positively with the severity of coronary atherosclerosis as determined by Gensini score (r = 0.47, P < 0.0001) or SYNTAX score (r = 0.55, P < 0.0001). Multiple regression analysis revealed that the expression of NLRP3 in SAT remains as an independent predictors for the severity of coronary atherosclerosis.ConclusionsThe expression of NLRP3 in SAT, which is affected by lifestyle-related diseases, is associated with the severity of coronary atherosclerosis. Our results suggest that NLRP3 inflammasome in SAT may have a role in atherogenesis.
(キーワード): Atherosclerosis / Adipose tissue / Inflammation / NLRP3 inflammasome / Lifestyle-related disease
(徳島大学機関リポジトリ): ● Metadata: 109532
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.atherosclerosis.2015.07.043
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26282945; ● Search Scopus @ Elsevier (PMID): 26282945; ● Search Scopus @ Elsevier (DOI): 10.1016/j.atherosclerosis.2015.07.043

(徳島大学機関リポジトリ: 109532, DOI: 10.1016/j.atherosclerosis.2015.07.043, PubMed: 26282945) Hara Tomoya, Daiju Fukuda, Tanaka Kimie, Higashikuni Yasutomi, Hirata Yoichiro, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Rivaroxaban, a novel oral anticoagulant, attenuates atherosclerotic plaque progression and destabilization in ApoE-deficient mice.,
Atherosclerosis, Vol.242, No.2, 639-646, 2015.

(要約): OBJECTIVE: Activated factor X (FXa) plays a key role in the coagulation cascade, whereas accumulating evidence suggests that it also contributes to the pathophysiology of chronic inflammation on the vasculature. In this study, we assessed the hypothesis that rivaroxaban (Riv), a direct FXa inhibitor, inhibits atherogenesis by reducing macrophage activation.METHODS AND RESULTS: Expression levels of PAR-1 and PAR-2, receptors for FXa, increased in the aorta of apolipoprotein E-deficient (ApoE(-/-)) mice compared with wild-type mice (P < 0.01, P < 0.05, respectively). Administration of Riv (5 mg/kg/day) for 20 weeks to 8-week-old ApoE(-/-) mice reduced atherosclerotic lesion progression in the aortic arch as determined by en-face Sudan IV staining compared with the non-treated group (P < 0.05) without alteration of plasma lipid levels and blood pressure. Histological analyses demonstrated that Riv significantly decreased lipid deposition, collagen loss, macrophage accumulation and matrix metallopeptidase-9 (MMP-9) expression in atherosclerotic plaques in the aortic root. Quantitative RT-PCR analyses using abdominal aorta revealed that Riv significantly reduced mRNA expression of inflammatory molecules, such as MMP-9, tumor necrosis factor- (TNF-). In vitro experiments using mouse peritoneal macrophages or murine macrophage cell line RAW264.7 demonstrated that FXa increased mRNA expression of inflammatory molecules (e.g., interleukin (IL)-1 and TNF-), which was blocked in the presence of Riv.CONCLUSIONS: Riv attenuates atherosclerotic plaque progression and destabilization in ApoE(-/-) mice, at least in part by inhibiting pro-inflammatory activation of macrophages. These results indicate that Riv may be particularly beneficial for the management of atherosclerotic diseases, in addition to its antithrombotic activity.
(キーワード): Activated factor X / 動脈硬化 (atherosclerosis) / Coagulation / 炎症 (inflammation) / Macrophages / Rivaroxaban
(徳島大学機関リポジトリ): ● Metadata: 109485
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.atherosclerosis.2015.03.023
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25817329; ● Summary page in Scopus @ Elsevier: 2-s2.0-84941742835

(徳島大学機関リポジトリ: 109485, DOI: 10.1016/j.atherosclerosis.2015.03.023, PubMed: 25817329, Elsevier: Scopus) Yukina Hirata, Hirotsugu Yamada, Kenya Kusunose, Takashi Iwase, Susumu Nishio, Shuji Hayashi, Mika Bando, Rie Amano, Koji Yamaguchi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Clinical Utility of Measuring Epicardial Adipose Tissue Thickness with Echocardiography Using a High-Frequency Linear Probe in Patients with Coronary Artery Disease.,
Journal of the American Society of Echocardiography, Vol.28, No.10, 1240-1246.e1, 2015.

(要約): The relationship between epicardial adipose tissue (EAT) and coronary artery disease (CAD) has recently attracted a great deal of attention in the medical community. The objective of this study was to determine whether measuring EAT thickness in the anterior interventricular groove (AIG) using echocardiography is feasible and whether this index can be a marker of CAD. A total of 311 patients (mean age, 67 ± 11 years; 208 men) who underwent coronary angiography between December 2011 and December 2013 were prospectively enrolled. EAT-AIG thickness and EAT thickness on the free wall of the right ventricle (RV) were measured in systole using a high-frequency linear probe. Seventy-one patients who underwent multidetector-row computed tomography were enrolled to validate the method for measuring EAT thickness using echocardiography. Subjects were divided into two groups, those with and without significant coronary stenosis, on the basis of findings on coronary angiography (≥ 75% luminal narrowing). EAT-AIG thickness measured using echocardiography was validated by computed tomography. EAT-AIG thickness was strongly correlated with EAT volume (r = 0.714, P < .001). The CAD group had thicker EAT-AIG than the non-CAD group (8.3 ± 3.0 vs 6.3 ± 2.5 mm, P < .001). EAT-RV thickness was greater in the CAD group than in the non-CAD group (5.0 ± 2.1 vs 4.4 ± 2.3 mm, P = .009) as well. The area under the curve on receiver operating characteristic curve analysis of EAT-AIG thickness for predicting CAD was 0.704, which was higher than the EAT-RV thickness. Measuring EAT thickness using echocardiography with a high-frequency linear probe was validated with computed tomography. EAT-AIG was thicker in the CAD group than in the non-CAD group, as was EAT-RV thickness. This noninvasive index may have potential as a diagnostic marker for predicting coronary atherosclerosis.
(徳島大学機関リポジトリ): ● Metadata: 109714
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.echo.2015.07.006
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26275751; ● Summary page in Scopus @ Elsevier: 2-s2.0-84944180106

(徳島大学機関リポジトリ: 109714, DOI: 10.1016/j.echo.2015.07.006, PubMed: 26275751, Elsevier: Scopus) Shusuke Yagi, Ken-ichi Aihara, Masashi Akaike, Daiju Fukuda, HM Salim, Masayoshi Ishida, Tomomi Matsuura, Takayuki Ise, Koji Yamaguchi, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Michio Shimabukuro, Toshio Matsumoto and Masataka Sata :
Predictive factors for efficacy of dipeptidyl peptidase-4 inhibitors in patients with type 2 diabetes mellitus.,
Diabetes & Metabolism Journal, Vol.39, No.4, 342-347, 2015.

(要約): BACKGROUND: Predictive factors for the efficacy of dipeptidyl peptidase-4 (DPP-4) inhibitors for lowering glycosylated hemoglobin (HbA1c) remain unclear in patients with type 2 diabetes mellitus. The aim of this study is therefore to clarify predictive factors of the efficacy of DPP-4 inhibitors for lowering HbA1c after 12 months of treatment.METHODS: A total of 191 consecutive type 2 diabetic patients (male sex 55%, mean age, 68.3±35.8 years), who had been treated with DPP-4 inhibitors for 12 months, were enrolled in this study and evaluated retrospectively.RESULTS: After 12 months of DPP-4 inhibitor treatment, random blood glucose level, and HbA1c level, decreased from 167±63 to 151±49 mg/dL (P<0.01), and from 7.5%±1.3% to 6.9%±0.9% (P<0.01) respectively, without severe side effects. Multiple regression analysis showed that predictors of DPP-4 inhibitor treatment efficacy in lowering HbA1c level after 12 months were a decrease in HbA1c level after 3 months of treatment, a high baseline HbA1c level, a low baseline body mass index, and the absence of coronary artery disease.CONCLUSION: Most suitable candidates for treatment with DPP-4 inhibitors are diabetics who are not obese and do not have coronary artery disease. In addition, long-term efficacy of DPP-4 inhibitors can be predicted by decrement of HbA1c after 3 months of treatment.
(キーワード): Coronary artery disease / 糖尿病 (diabetes mellitus) / Dipeptidyl-peptidase IV inhibitors / Obese / Predictive factors
(出版サイトへのリンク): ● Publication site (DOI): 10.4093/dmj.2015.39.4.342
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26301197; ● Summary page in Scopus @ Elsevier: 2-s2.0-84939780057

(DOI: 10.4093/dmj.2015.39.4.342, PubMed: 26301197, Elsevier: Scopus) Kenya Kusunose, Hirotsugu Yamada, Junko Hotsuchi, Mika Bando, Susumu Nishio, Yukina Hirata, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki, Jun Kishi and Masataka Sata :
Prediction of Future Overt Pulmonary Hypertension by 6-Min Walk Stress Echocardiography in Patients With Connective Tissue Disease.,
Journal of the American College of Cardiology, Vol.66, No.4, 376-384, 2015.

(要約): BACKGROUND: Early detection of pulmonary hypertension (PH) in connective tissue disease (CTD) is crucial to ensuring that patients receive timely treatment for this progressive disease. Exercise stress tests have been used to screen patients in an attempt to identify early-stage PH. Recent studies have described abnormal mean pulmonary artery pressure (mPAP)-cardiac output (Q) responses as having the potential to assess the disease state.OBJECTIVES: This study hypothesized that pulmonary circulation pressure-flow relationships obtained by 6-min walk (6MW) stress echocardiography would better delineate differential progression of PH and predict development of PH during follow-up.METHODS: We prospectively performed 6MW stress echocardiographic studies in 78 CTD patients (age 58 ± 12 years; 9% male) at baseline and follow-up. All patients underwent yearly echocardiographic follow-up studies for up to 5 years.RESULTS: During a median period of 32 months (range: 15 to 62 months), 16 patients reached the clinical endpoint of development of PH and none died during follow-up. PH was confirmed by right heart catheterization in all 16 patients (mPAP 25 mm Hg and pulmonary capillary wedge pressure 15 mm Hg). In a Cox proportional-hazards survival model, 6MW distance (hazard ratio [HR]: 0.99; p = 0.010), early diastolic tricuspid annulus motion velocity (HR: 0.79; p = 0.025), and mPAP/Q by 6MW stress (HR: 1.10; p = 0.005) were associated with development of PH. In sequential Cox models, a model on the basis of 6MW distance (chi-square, 6.6) was improved by mPAP/Q (chi-square: 14.4; p = 0.019). Using a receiver-operating characteristic curve, we found that the best cutoff value of mPAP/Q for predicting development of pulmonary hypertension was >3.3 mm Hg/l/min.CONCLUSIONS: The 6MW stress echocardiography noninvasively provides an incremental prognostic value of PH development in CTD. This is a single-center prospective cohort study. Larger multicenter studies are warranted to confirm this result.
(キーワード): lupus erythematosus / mixed connective tissue disease / pulmonary circulation / systemic scleroderma
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jacc.2015.05.032
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26205595; ● Summary page in Scopus @ Elsevier: 2-s2.0-84937681606

(DOI: 10.1016/j.jacc.2015.05.032, PubMed: 26205595, Elsevier: Scopus) Mika Bando, Hirotsugu Yamada, Kenya Kusunose, Daiju Fukuda, Rie Amano, Rina Tamai, Yuta Torii, Yukina Hirata, Susumu Nishio, Koji Yamaguchi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Comparison of carotid plaque tissue characteristics in patients with acute coronary syndrome or stable angina pectoris: assessment by iPlaque, transcutaneous carotid ultrasonography with integrated backscatter analysis.,
Cardiovascular Ultrasound, Vol.13, No.1, 34, 2015.

(要約): BACKGROUND: The association of the tissue characteristics of carotid plaques with coronary artery disease has attracted interest. The present study compared the tissue characteristics of carotid plaques in patients with acute coronary syndrome (ACS) with those in patients with stable angina pectoris (SAP) using the iPlaque system, which is based on ultrasound integrated backscatter.METHODS AND RESULTS: Carotid ultrasound examinations were performed in 26 patients with ACS, and 38 age- and gender-matched patients with SAP. Neither plaque area nor maximal intima-media thickness differed significantly between the two groups. However, the average integrated backscatter value within the plaque was greater in the ACS patients than in the SAP patients. iPlaque analysis revealed that the percentage blue area (lipid pool) was greater in the ACS patients than in the SAP patients (43.4±11.2 vs 18.3±10.3 %, p<0.0001), and that the percentage green area (fibrosis) was lower in the ACS than in the SAP patients (7.5±7.5 % vs 20.7±11.7 %, p<0.0001).CONCLUSIONS: The lipid component of carotid plaques is greater in ACS patients than in SAP patients. Our iPlaque system provides a useful and feasible method for the tissue characterization of carotid plaques in the clinical setting.
(キーワード): Carotid arteries / Plaque vulnerability / 超音波 (ultrasound) / Acute coronary syndrome (ACS)
(徳島大学機関リポジトリ): ● Metadata: 109520
(出版サイトへのリンク): ● Publication site (DOI): 10.1186/s12947-015-0031-6
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26209244; ● Summary page in Scopus @ Elsevier: 2-s2.0-84937791819

(徳島大学機関リポジトリ: 109520, DOI: 10.1186/s12947-015-0031-6, PubMed: 26209244, Elsevier: Scopus) Hiromu Yamazaki, Koji Yamaguchi, Takeshi Soeki, Tetsuzo Wakatsuki, Toshiyuki Niki, Yoshio Taketani, Atsunori Kitaoka, Kenya Kusunose, Takayuki Ise, Takeshi Tobiume, Shusuke Yagi, Takashi Iwase, Hirotsugu Yamada and Masataka Sata :
Impact of indoxyl sulfate, a uremic toxin, on non-culprit coronary plaque composition assessed by integrated backscatter intravascular ultrasound.,
Circulation Journal, Vol.79, No.8, 1773-1779, 2015.

(要約): BACKGROUND: Uremic toxin has emerged as an important determinant of cardiovascular risk. The aim of this study was to examine the relationship between serum uremic toxin and coronary plaque composition on integrated backscatter intravascular ultrasound (IB-IVUS).MethodsandResults:IB-IVUS was performed in 47 patients with planned treatment for angina pectoris. Non-culprit intermediate plaque analyzed in this study had to be >5 mm apart from the intervention site. 3-D IB-IVUS analysis was performed to determine percent lipid volume (LV) and fibrous volume (FV). We also measured serum uremic toxins (indoxyl sulfate [IS], asymmetric dimethylarginine [ADMA], and p-cresol [PC]). Glomerular filtration rate correlated with IS (r=-0.329, P=0.04), but did not correlate with ADMA or PC. Percent LV correlated with IS (r=0.365, P=0.02), but did not correlate with ADMA or PC. Percent FV also correlated with IS (r=-0.356, P=0.03), but did not correlate with ADMA or PC. On multivariate regression, only IS was associated with percent LV (r=0.359, P=0.04) and percent FV (r=-0.305, P=0.04) independently of potentially confounding coronary risk factors.CONCLUSIONS: Among the uremic toxins, serum IS might be a novel useful biomarker to detect and monitor lipid-rich coronary plaque on IB imaging. (Circ J 2015; 79: 1773-1779).
(キーワード): Coronary plaque / Indoxyl sulfate / Integrated backscatter intravascular ultrasound
(徳島大学機関リポジトリ): ● Metadata: 109533
(出版サイトへのリンク): ● Publication site (DOI): 10.1253/circj.CJ-15-0019
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25971408; ● Summary page in Scopus @ Elsevier: 2-s2.0-84937904061

(徳島大学機関リポジトリ: 109533, DOI: 10.1253/circj.CJ-15-0019, PubMed: 25971408, Elsevier: Scopus) Kenya Kusunose, Junko Hotsuchi, Y Takagawa, S Nishio, Takayuki Ise, Takeshi Tobiume, Koji Yamaguchi, Shusuke Yagi, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Serial imaging changes during treatment of immunoglobulin G4-related disease with multiple pseudotumors.,
Circulation, Vol.131, No.21, 1882-1883, 2015.

(キーワード): Aged, 80 and over / Antibodies, Anti-Idiotypic / Arteries / Cardiomegaly / Coronary Aneurysm / Eyelid Diseases / Fluorodeoxyglucose F18 / Humans / Immunoglobulin G / Male / Paraproteinemias / Plasma Cells / Positron-Emission Tomography / Radiopharmaceuticals / Tomography, X-Ray Computed
(出版サイトへのリンク): ● Publication site (DOI): 10.1161/CIRCULATIONAHA.115.015638
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26015466; ● Summary page in Scopus @ Elsevier: 2-s2.0-84936080389

(DOI: 10.1161/CIRCULATIONAHA.115.015638, PubMed: 26015466, Elsevier: Scopus) Shusuke Yagi, Ken-ichi Aihara, Daiju Fukuda, Akira Takashima, Tomoya Hara, Junko Hotsuchi, Takayuki Ise, Koji Yamaguchi, Takeshi Tobiume, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Michio Shimabukuro, Masashi Akaike and Masataka Sata :
Effects of docosahexaenoic acid on the endothelial function in patients with coronary artery disease.,
Journal of Atherosclerosis and Thrombosis, Vol.22, No.5, 447-454, 2015.

(要約): AIM: The consumption of n-3 polyunsaturated fatty acids (PUFA), including docosahexaenoic acid DHA), reduces the incidence of cardiovascular events, and reduced serum levels of n-3 PUFA may be associated with an increased risk of cardiovascular events. However, controversy remains regarding which components of PUFA are associated with the endothelial function in patients with coronary artery disease (CAD). We therefore examined the associations between the n-3 and n-6 PUFA levels and CAD.METHODS: We retrospectively reviewed 160 consecutive Japanese patients with CAD whose endothelial function was measured according to the percent change in flow-mediated dilation (FMD) and the serum levels of n-3 PUFA, including eicosapentaenoic acid (EPA) and DHA, and n-6 PUFA, including arachidonic acid (AA) and dihomo-gamma-linolenic acid (DHLA).RESULTS: A single regression analysis showed no relationships between the FMD and the serum levels of PUFA, including EPA, DHA, AA and DHLA. In contrast, a multiple regression analysis showed that the DHA level was a positive (P0.01) and age was a negative (P0.001) contributor to an increased FMD; however, sex, body mass index, systolic and diastolic blood pressure, current/past smoking and the levels of HbA1c, triglycerides, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, EPA, AA and DHLA did not significantly affect the outcome.CONCLUSIONS: The serum level of DHA is associated with the endothelial function evaluated according to the FMD in patients with CAD, thus suggesting that a low serum level of DHA may be a predictive biomarker for endothelial dysfunction.
(キーワード): Flow-mediated dilation / n-3 polyunsaturated fatty acids / Docosahexaenoic acid
(出版サイトへのリンク): ● Publication site (DOI): 10.5551/jat.26914
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25342567; ● CiNii @ 国立情報学研究所 (CRID): 1390001204431540352; ● Summary page in Scopus @ Elsevier: 2-s2.0-84929412906

(DOI: 10.5551/jat.26914, PubMed: 25342567, CiNii: 1390001204431540352, Elsevier: Scopus) Toshiyuki Niki, Takeshi Soeki, Koji Yamaguchi, Yoshio Taketani, Shusuke Yagi, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Elevated concentration of interferon-inducible protein of 10 kD (IP-10) is associated with coronary atherosclerosis.,
International Heart Journal, Vol.56, No.3, 269-272, 2015.

(要約): Several studies have shown that various chemokines are more highly expressed in atherosclerotic plaques than in normal vessel walls. In the present study, we investigated the relationship between coronary atherosclerosis and noteworthy chemokines, including interferon-inducible protein of 10 kD (IP-10); monocyte chemoattractant protein 1 (MCP-1); regulated on activation, normal T-cell expressed and secreted (RANTES); and high-sensitivity C-reactive protein (hsCRP), an established marker of atherosclerotic disease. We studied 28 patients who underwent coronary angiography because of suspected coronary artery disease (CAD). CAD was defined as stenosis of more than 50% of the vessel diameter on coronary angiograms. Blood samples were obtained both from the aorta and the coronary sinus (CS) just before coronary angiography. Relative to CAD (-) patients, those who were CAD (+) tended to have higher plasma concentrations of IP-10 in the aorta, as well as significantly higher transcoronary concentration gradients of circulating IP-10. There were no significant differences between the two groups in aortic plasma concentrations or transcoronary concentration gradients of MCP-1, RANTES, and hsCRP. Furthermore, both the aortic plasma concentrations and transcoronary concentration gradients of IP-10 correlated with the Gensini score (r = 0.58 and r = 0.63, respectively, P < 0.01), while the plasma MCP-1, RANTES, and serum hsCRP concentrations did not. This study suggests that IP-10 is a good surrogate marker of coronary atherosclerosis.
(キーワード): Coronary artery disease / Coronary circulation / Chemokine
(出版サイトへのリンク): ● Publication site (DOI): 10.1536/ihj.14-300
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25902883; ● Search Scopus @ Elsevier (PMID): 25902883; ● Search Scopus @ Elsevier (DOI): 10.1536/ihj.14-300

(DOI: 10.1536/ihj.14-300, PubMed: 25902883) Takeshi Soeki, Koji Yamaguchi, Toshiyuki Niki, E Uematsu, S Bando, T Matsuura, Takayuki Ise, Kenya Kusunose, Junko Hotsuchi, Takeshi Tobiume, Shusuke Yagi, Daiju Fukuda, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Plasma microRNA-100 is associated with coronary plaque vulnerability.,
Circulation Journal, Vol.79, No.2, 413-418, 2015.

(要約): BACKGROUND: Although numerous studies have reported altered plasma levels of various microRNAs (miRNAs) in patients with cardiovascular disease, there are no data on the relationship between plasma miRNAs and vulnerable coronary plaque. In this study, we investigated whether plasma miRNAs might be a sensitive marker of coronary plaque vulnerability.MethodsandResults:Integrated backscatter intravascular ultrasound (IB-IVUS) was performed in 32 consecutive patients with angina pectoris who underwent percutaneous coronary intervention. Three-dimensional analysis of IB-IVUS was performed to determine the percentage of lipid volume (%LV) and fibrous volume (%FV). Circulating miRNAs were measured in EDTA-plasma simultaneously obtained from the aorta and the coronary sinus (CS). Muscle-enriched (miR-133a, miR-208a, miR-499), vascular-enriched (miR-92a, miR-100, miR-126, miR-127, miR-145), and myeloid cell-enriched miRNAs (miR-155, miR-223) were measured. Plasma miR-100 was higher in the CS than in the aorta, but there were no significant differences in the levels of other miRNAs between the aorta and CS. Plasma miR-100 in the aorta was positively correlated with %LV (r=0.48, P<0.01) and negatively correlated with %FV (r=-0.41, P<0.05). Importantly, transcoronary concentration gradient of circulating miR-100 was more strongly correlated with %LV (r=0.53, P<0.01) and %FV (r=-0.56, P<0.01).CONCLUSIONS: miR-100 might be released into the coronary circulation from vulnerable coronary plaques. This study provides insights into the role of miRNAs in coronary atherosclerotic disease. (Circ J 2015; 79: 413-418).
(キーワード): Coronary artery disease / Coronary circulation / Intravascular ultrasound / MicroRNA
(出版サイトへのリンク): ● Publication site (DOI): 10.1253/circj.CJ-14-0958
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25519160; ● CiNii @ 国立情報学研究所 (CRID): 1390001205108464000; ● Summary page in Scopus @ Elsevier: 2-s2.0-84928251309

(DOI: 10.1253/circj.CJ-14-0958, PubMed: 25519160, CiNii: 1390001205108464000, Elsevier: Scopus) S Kimura, Yuka Ueda, Takayuki Ise, Shusuke Yagi, Takashi Iwase, K Nishikawa, Koji Yamaguchi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Shinsuke Katoh, Masashi Akaike, Natsuo Yasui and Masataka Sata :
Impact of supervised cardiac rehabilitation on urinary albumin excretion in patients with cardiovascular disease.,
International Heart Journal, Vol.56, No.1, 105-109, 2015.

(要約): Urinary albumin excretion is a predictor of cardiovascular death. Cardiac rehabilitation (CR) with exercise training (ET) has been shown to improve exercise capacity and prognosis in patients with cardiovascular disease (CVD). However, it remains unclear whether CR reduces urinary albumin excretion in CVD patients. We performed a retrospective, observational study using data obtained from 98 male CVD patients without macroalbuminuria and estimated glomerular filtration rate (eGFR) < 30 mL/minute/1.73 m(2) who participated in CR with ET during hospitalization. Twenty-three patients continued supervised ET for 6 months (supervised group) and 75 patients quit supervised ET (non-supervised group). The supervised ET program consisted of 60 minutes of supervised sessions 1-3 times a week and 30-60 minutes of home exercise at least twice a week. Urinary albumin/creatinine ratio (ACR) was significantly decreased in the supervised group at 6 months after enrollment (43 ± 71 mg/g to 17 ± 20 mg/g creatinine, P < 0.05) but not in the non-supervised group. eGFR was unchanged in the supervised group but was significantly decreased in the non-supervised group (72 ± 18 mL/minute/1.73 m(2) to 67 ± 17 mL/minute/1.73 m(2), P < 0.001). The results of multiple regression analysis showed that only supervised ET was an independent contributor to ACR. CR with supervised ET decreased urinary albumin excretion without deterioration of renal function. These findings suggest that continuation of a supervised ET program is associated with reduction in the development of CVD and reduction in cardiovascular morbidity and mortality in CVD patients.
(キーワード): Cardiac rehabilitation / Renal function / Cardiovascular disease
(徳島大学機関リポジトリ): ● Metadata: 109367
(出版サイトへのリンク): ● Publication site (DOI): 10.1536/ihj.14-161
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25742947; ● Search Scopus @ Elsevier (PMID): 25742947; ● Search Scopus @ Elsevier (DOI): 10.1536/ihj.14-161

(徳島大学機関リポジトリ: 109367, DOI: 10.1536/ihj.14-161, PubMed: 25742947) Shusuke Yagi, A Takashima, M Mitsugi, T Wada, Junko Hotsuchi, Ken-ichi Aihara, T Hara, Masayoshi Ishida, Daiju Fukuda, Takayuki Ise, Koji Yamaguchi, Takeshi Tobiume, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Michio Shimabukuro, Masashi Akaike and Masataka Sata :
Effect of combination tablets containing amlodipine 10 mg and irbesartan 100 mg on blood pressure and cardiovascular risk factors in patients with hypertension.,
Therapeutics and Clinical Risk Management, Vol.11, 83-88, 2015.

(要約): Background: Hypertension is one of the major risk factors for cardiovascular and cerebrovascular disease and mortality. Patients who receive insufficient doses of antihypertensive agents or who are poorly adherent to multidrug treatment regimens often fail to achieve adequate blood pressure (BP) control. The aim of this study was to determine the efficacy of an angiotensin II receptor blocker (ARB) and calcium channel blocker (CCB) combination tablet containing a regular dose of irbesartan (100 mg) and a high dose of amlodipine (10 mg) with regard to lowering BP and other risk factors for cardiovascular disease.Methods: We retrospectively evaluated data from 68 patients with essential hypertension whose treatment regimen was changed either from combination treatment with an independent ARB and a low-dose or regular-dose CCB or from a combination tablet of ARB and a low-dose or regular-dose CCB to a combination tablet containing amlodipine 10 mg and irbesartan 100 mg, because of incomplete BP control. Previous treatments did not include irbesartan as the ARB.Results: The combination tablet decreased systolic and diastolic BP. In addition, it significantly decreased serum uric acid, low-density lipoprotein cholesterol, and increased high-density lipoprotein cholesterol levels, independent of the BP-lowering effect. Treatment with the combination tablet did not affect serum triglycerides, plasma glucose, glycated hemoglobin, serum potassium or creatinine levels, or the urinary albumin excretion rate.Conclusion: The combination tablet containing amlodipine 10 mg and irbesartan 100 mg had a greater BP-lowering effect than an ARB and a low-dose or regular-dose CCB. In addition, the combination tablet had more favorable effects on serum uric acid, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol levels in patients with hypertension.
(キーワード): blood pressure / combination tablet / uric acid / low-density lipoprotein cholesterol / high-density lipoprotein cholesterol
(出版サイトへのリンク): ● Publication site (DOI): 10.2147/TCRM.S72299
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25624765; ● Summary page in Scopus @ Elsevier: 2-s2.0-84921260560

(DOI: 10.2147/TCRM.S72299, PubMed: 25624765, Elsevier: Scopus) Masato Nakamura, Masakazu Yamagishi, Takafumi Ueno, Kazuhiro Hara, Sugao Ishiwata, Tomonori Itoh, Ichiro Hamanaka, Tetsuzo Wakatsuki, Teruyasu Sugano, Kazuya Kawai, Takashi Akasaka, Nobuhiro Tanaka and Takeshi Kimura :
Modification of treatment strategy after FFR measurement: CVIT-DEFER registry.,
Cardiovascular Intervention and Therapeutics, Vol.30, No.1, 12-21, 2015.

(要約): The impact of the fractional flow reserve (FFR) on clinical decision-making remains unclear in daily practice. The CVIT-DEFER registry is a prospective multicenter registry enrolling consecutive patients with angiographically intermediate coronary stenosis for whom FFR measurement is clinically indicated. The treatment strategy determined from angiographic findings alone and the strategy selected after FFR measurement were compared. Data on the treatment strategy were obtained for 3093 subjects. The average age of these subjects was 69.5 ± 10.2 years and 73.8 % were men. The majority had stable coronary artery disease, including 60.4 % with stable angina pectoris. The treatment strategy based on angiographic findings was medical management in 34.5 %, percutaneous coronary intervention (PCI) in 63.5 %, and coronary artery bypass grafting in 2.1 %. The FFR was 0.8 in 1566 lesions (42.2 %). After FFR measurement, medical treatment was changed to revascularization in 19.7 %, while PCI was switched to medical treatment in 57.4 % at the lesion level. As a result, reclassification of the treatment strategy at the patient level was done in 39.0 % of the patients. Revascularization was frequently switched to medical treatment after FFR measurement. These findings support the clinical utility of employing FFR data to guide selection of PCI.
(キーワード): Fractional flow reserve / Functional coronary artery stenosis / Angiography / Coronary artery stenosis / Treatment strategy
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s12928-014-0266-4
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24816634; ● Summary page in Scopus @ Elsevier: 2-s2.0-84921935602

(DOI: 10.1007/s12928-014-0266-4, PubMed: 24816634, Elsevier: Scopus) Shusuke Yagi, T Hara, R Ueno, Ken-ichi Aihara, Daiju Fukuda, A Takashima, Junko Hotsuchi, Takayuki Ise, Koji Yamaguchi, Takeshi Tobiume, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Michio Shimabukuro, Masashi Akaike and Masataka Sata :
Serum concentration of eicosapentaenoic acid is associated with cognitive function in patients with coronary artery disease.,
Nutrition Journal, Vol.13, No.1, 112, 2014.

(要約): BACKGROUND: Recent studies have shown that intake of n-3 polyunsaturated fatty acids (PUFAs) is associated with reduced risk of cognitive impairment and coronary artery disease (CAD); however, it is currently unknown whether reduced serum n-3 PUFA is associated with cognitive impairment in patients with CAD.METHODS: We retrospectively evaluated cognitive function with the mini-mental state examination (MMSE), serum levels of PUFAs (including eicosapentaenoic acid [EPA], docosahexaenoic acid [DHA], dihomogammalinolenic acid [DGLA], and arachidonic acid [AA]), cardiovascular risk factors (hypertension, dyslipidemia, diabetes mellitus, cerebrovascular disease, and history of current/previous smoking), and parameters of cardiac function (left ventricular ejection fraction and brain natriuretic peptide levels) in 146 Japanese CAD patients. The associations between the MMSE scores and the other parameters were evaluated.RESULTS: Pearson correlation analysis showed that EPA (R =0.25, P <0.01), EPA/AA ratio (R =0.22, P =0.01), and left ventricular ejection fraction (R =0.15, P =0.04) were positively associated with MMSE score, and that age (R = -0.20, P <0.01) and brain natriuretic peptide levels (R = -0.28, P <0.01) were inversely associated with MMSE score. Multiple regression analysis showed that age (P <0.05) was negatively associated with MMSE score, while EPA (P <0.01) and EPA/AA ratio (P <0.05) were positively associated with MMSE score; however, sex; body mass index; left ventricular ejection fraction; levels of DHA, AA, and DGLA; DHA/AA ratio; brain natriuretic peptide; and presence of hypertension, dyslipidemia, diabetes mellitus, cerebrovascular disease, and history of current/previous smoking were statistically excluded.CONCLUSIONS: Serum EPA concentration is associated with cognitive function in patients with CAD, suggesting that a low serum EPA level is a risk factor for cognitive impairment independent of cardiac function, including left ventricular ejection fraction. This correlation potentially lends further support to a role of dietary n-3 PUFAs in preventing the cognitive decline in CAD patients.
(キーワード): Aged / Arachidonic Acid / Cognition / Cognition Disorders / Coronary Disease / Eicosapentaenoic Acid / Fatty Acids, Omega-3 / Female / Humans / Japan / Male / Middle Aged / Retrospective Studies / Risk Factors / Stroke Volume
(出版サイトへのリンク): ● Publication site (DOI): 10.1186/1475-2891-13-112
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25471307; ● Summary page in Scopus @ Elsevier: 2-s2.0-84926465688

(DOI: 10.1186/1475-2891-13-112, PubMed: 25471307, Elsevier: Scopus) Takeshi Soeki, Kunihiko Koshiba, Toshiyuki Niki, Kenya Kusunose, Koji Yamaguchi, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro, Kazuo Minakuchi, I Kishimoto, Kenji Kangawa and Masataka Sata :
Effect of ghrelin on autonomic activity in healthy volunteers.,
Peptides, Vol.62, 1-5, 2014.

(要約): Ghrelin is a novel growth hormone (GH)-releasing peptide originally isolated from the stomach. Recently, we have shown that ghrelin suppresses cardiac sympathetic activity and prevents early left ventricular remodeling in rats with myocardial infarction. In the present study, we evaluated the effect of ghrelin on autonomic nerve activity in healthy human subjects. An intravenous bolus of human synthetic ghrelin (10g/kg) was administered to 10 healthy men (mean age, 33 years). Holter monitoring assessment was performed before and during 2h after the ghrelin therapy. The standard deviation of normal RR intervals (SDNN), square root of the mean of the sum of the squares of differences between adjacent RR intervals (rMSSD), high-frequency power (HF), and low-frequency power (LF) were analyzed. Blood samples were also obtained before and after the therapy. A single administration of ghrelin decreased both heart rate and blood pressure. Interestingly, ghrelin significantly decreased the LF and LF/HF ratio of heart rate variability and increased the SDNN, rMSSD, and HF. Ghrelin also elicited a marked increase in circulating GH, but not insulin-like growth factor-1. These data suggest that ghrelin might suppress cardiac sympathetic nerve activity and stimulate cardiac parasympathetic nerve activity.
(キーワード): Ghrelin / Autonomic nerve activity / Heart rate variability / Electrocardiography / Hemodynamics
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.peptides.2014.09.015
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25265271; ● Search Scopus @ Elsevier (PMID): 25265271; ● Search Scopus @ Elsevier (DOI): 10.1016/j.peptides.2014.09.015

(DOI: 10.1016/j.peptides.2014.09.015, PubMed: 25265271) Koji Yamaguchi, Tetsuzo Wakatsuki, Takeshi Soeki, Toshiyuki Niki, Yoshio Taketani, Hiroyasu Oeduka, Kenya Kusunose, Takayuki Ise, Takashi Iwase, Hirotsugu Yamada and Masataka Sata :
Effects of telmisartan on inflammatory cytokines and coronary plaque component as assessed on integrated backscatter intravascular ultrasound in hypertensive patients.,
Circulation Journal, Vol.78, No.1, 240-247, 2014.

(要約): Telmisartan has unique pleiotropic effects in addition to renin-angiotensin system (RAS)-inhibition effects. The aim of this study was to evaluate the effects of telmisartan on the coronary plaque component and local inflammatory cytokines. A total of 50 patients with hypertension were randomized to 2 groups: the telmisartan group (additional treatment with telmisartan 80mg/day, n=25) or the control group (additional treatment with other anti-hypertensive drugs except RAS blockers, n=25) for 6 months. Tissue characteristics of target coronary plaque were analyzed using integrated backscatter intravascular ultrasound (IB-IVUS) before and after treatment. Plasma levels of inflammatory cytokines sampled in the coronary sinus (CS) and peripheral vein were also measured. Significant increases in fibrous volume (51.2±10.4 to 58.3±7.7%, P=0.03) and reductions in lipid volume (38.4±12.4 to 32.8±9.7%, P=0.03) were observed on IB in the telmisartan group, while there were no significant changes in the plaque component in the control group. CS levels of inflammatory cytokines (matrix metalloproteinase [MMP]3, tumor necrosis factor-, high-sensitivity C-reactive protein and MMP9) were lower after than before treatment in the only telmisartan group (7.7±6.1 to 5.5±4.9ng/ml, 3.1±1.9 to 2.3±2.0pg/ml, 5.6±6.0 to 2.2±2.4mg/L, 36.1±39.3 to 19.9±27.5ng/ml, P=0.02, P=0.03, P=0.04, P=0.07, respectively). Decreased local inflammatory response and plaque stabilization on IB imaging were observed after 6 months of telmisartan treatment. These findings might be associated with local anti-inflammatory and anti-arteriosclerotic effects of telmisartan.
(キーワード): Coronary plaque / Inflammatory cytokine / Integrated backscatter intravascular ultrasound / Telmisartan
(出版サイトへのリンク): ● Publication site (DOI): 10.1253/circj.CJ-13-0741
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24189463; ● CiNii @ 国立情報学研究所 (CRID): 1390282680085613824; ● Summary page in Scopus @ Elsevier: 2-s2.0-84891099318

(DOI: 10.1253/circj.CJ-13-0741, PubMed: 24189463, CiNii: 1390282680085613824, Elsevier: Scopus) A Takashima, Takayuki Ise, Shusuke Yagi, Takashi Iwase, S Kimura, Yuka Ueda, K Nishikawa, A Ishii, Toshiyuki Niki, Koji Yamaguchi, Yoshio Taketani, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Shinsuke Katoh, Masashi Akaike and Masataka Sata :
Cardiac rehabilitation reduces serum levels of oxidized low-density lipoprotein.,
Circulation Journal, Vol.78, No.11, 2682-2687, 2014.

(要約): BACKGROUND: Oxidized low-density lipoprotein (oxLDL) levels have been found to play an important role in the progression of atherosclerosis. However, methods for effectively reducing oxLDL levels have not been established. Comprehensive cardiac rehabilitation (CR) with exercise training prevents the progression of atherosclerosis, and might reduce oxLDL levels.MethodsandResults:We measured the serum levels of malondialdehyde-modified LDL (MDA-LDL), a marker of oxLDL, in 136 patients who were enrolled in a 6-month CR program. Peak oxygen consumption (VO2) and MDA-LDL levels were analyzed, before and 6 months after enrolment. In total, 67 patients completed the CR program (CR group) and 69 patients failed to complete the program (non-CR group). Peak VO2increased significantly in the CR group (P<0.01). The levels of MDA-LDL decreased significantly in the CR group (P<0.01) but not in the non-CR group. VO2(peak VO2after CR-peak VO2before CR) was negatively associated with MDA-LDL (MDA-LDL after CR-MDA-LDL before CR) (R(2)=0.11, P=0.01). Multiple regression analysis showed that continuing CR was an independent determining factor for lowering MDA-LDL levels.CONCLUSIONS: CR decreases oxLDL levels in patients with cardiovascular diseases. Moreover, CR may prevent cardiovascular events through an antioxidative effect. (Circ J 2014; 78: 2682-2687).
(キーワード): Cardiac rehabilitation / Lipoproteins / Oxidative stress
(徳島大学機関リポジトリ): ● Metadata: 109368
(出版サイトへのリンク): ● Publication site (DOI): 10.1253/circj.CJ-14-0532
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25241889; ● Search Scopus @ Elsevier (PMID): 25241889; ● Search Scopus @ Elsevier (DOI): 10.1253/circj.CJ-14-0532

(徳島大学機関リポジトリ: 109368, DOI: 10.1253/circj.CJ-14-0532, PubMed: 25241889) M Nakamura, M Yamagishi, T Ueno, K Hara, S Ishiwata, T Itoh, I Hamanaka, Tetsuzo Wakatsuki, T Sugano, K Kawai, T Akasaka, N Tanaka and T Kimura :
Prevalence of visual-functional mismatch regarding coronary artery stenosis in the CVIT-DEFER registry.,
Cardiovascular Intervention and Therapeutics, Vol.29, No.4, 300-308, 2014.

(要約): The fractional flow reserve (FFR) is considered to be a reliable index for the assessment of clinically relevant coronary artery stenosis. However, mismatch in assessing the severity of coronary stenosis between coronary angiography and the FFR has been pointed out. The cardiovascular intervention therapeutics (CVIT)-DEFER registry is a prospective multicenter registry study that has enrolled 3,228 consecutive patients among 3,804 patients with angiographically moderate coronary artery lesions in whom FFR analysis was clinically indicated. The demographic and angiographic parameters associated with an FFR 0.8 were analyzed, and the incidence of discrepancy between the angiographic severity of coronary stenosis and the FFR was assessed. Based on the visual assessment, 1,609 (42.9%) lesions were categorized as showing 50% stenosis, 1,882 lesions (50.2%) as 75% stenosis, and 257 lesions (6.9%) as 90% stenosis. Angiographic-FFR "mismatch," which was defined as visual stenosis 75% with FFR >0.80, was found in 43.4% of lesions, while reverse angiographic mismatch (visual stenosis <75% with FFR 0.8) was found in 23.2%. The independent predictors for "angiographic-FFR mismatch" were the presence of percutaneous coronary intervention (PCI) history, one-vessel disease, non-left anterior descending artery (LAD) location, non-diffuse lesion, non-ostial lesion, and non-tandem lesion. Conversely, "reverse angiographic mismatch" was independently associated with the multivessel disease, LAD location, and diffuse lesion. The FFR is not only influenced by luminal stenosis but also by coronary artery morphology and the amount of jeopardized myocardium. Angiographic-FFR mismatch is frequent in patients with moderate coronary stenosis, which suggests the clinical importance of using physiological assessment to guide PCI.
(キーワード): Angiographic coronary stenosis / Functional coronary stenosis / FFR
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s12928-014-0259-3
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24664513; ● Search Scopus @ Elsevier (PMID): 24664513; ● Search Scopus @ Elsevier (DOI): 10.1007/s12928-014-0259-3

(DOI: 10.1007/s12928-014-0259-3, PubMed: 24664513) Takeshi Soeki, S Bando, E Uematsu, T Matsuura, Toshiyuki Niki, Takayuki Ise, Kenya Kusunose, Junko Hotsuchi, Yuka Ueda, N Tomita, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Pentraxin 3 is a local inflammatory marker in atrial fibrillation.,
Heart and Vessels, Vol.29, No.5, 653-658, 2014.

(要約): Increasing evidence indicates that inflammation contributes to the pathogenesis of atrial fibrillation (AF). Pentraxin 3 (PTX3) is produced abundantly in local inflammatory lesions while C-reactive protein (CRP) is produced mainly in the liver. In this study, we investigated whether a local level of PTX3 might be a sensitive marker for the local inflammation of AF. Blood from the periphery and left atrial appendage (LAA) was sampled from 23 patients with AF undergoing pulmonary vein isolation, and from 10 control subjects with Wolff-Parkinson-White syndrome. We measured peripheral and LAA plasma concentrations of CRP, interleukin-6 (IL-6), tumor necrosis factor- (TNF-), and PTX3. Plasma PTX3 concentrations in both locations were higher in patients with AF than in control subjects. PTX3 concentrations were significantly higher in the LAA than the periphery in patients with AF (3.7 ± 1.4 vs 3.3 ± 1.2 ng/ml, P < 0.01), but not in control subjects (2.4 ± 0.5 vs 2.4 ± 0.5 ng/ml, not significant). Patients and controls showed no significant differences in CRP, IL-6, or TNF- concentrations between the periphery and LAA. Interestingly, there was a significant positive correlation between LAA plasma concentrations of PTX3 and left atrial volume (r = 0.55, P < 0.01). These data demonstrate that Local PTX3 production in the left atrium might reflect the local inflammation of AF.
(キーワード): Pentraxin 3 / Atrial fibrillation / 炎症 (inflammation)
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s00380-013-0400-8
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23979265; ● Summary page in Scopus @ Elsevier: 2-s2.0-84929517476

(DOI: 10.1007/s00380-013-0400-8, PubMed: 23979265, Elsevier: Scopus) Shusuke Yagi, M Fujimura, Masashi Akaike, Ken-ichi Aihara, Takashi Iwase, M Tada, Yuka Ueda, Takayuki Ise, Koji Yamaguchi, Tetsuzo Wakatsuki, Toshio Matsumoto and Masataka Sata :
Increase in serum triglyceride was associated with coronary plaque vulnerability in a patient with rheumatoid arthritis.,
Journal of Cardiology Cases, Vol.10, No.2, 54-57, 2014.

(要約): Rates of morbidity and mortality from cardiovascular disease are high in patients with rheumatoid arthritis (RA); however, the mechanisms and biomarkers that reflect coronary plaque vulnerability have not yet been established. We present a case of acute coronary syndrome (ACS) presumably caused by exacerbation of chronic inflammation of RA, in which an abrupt increase in serum triglyceride was seen on the day of onset of ACS but not during effort angina. This case suggests that RA patients with an abrupt increase in triglyceride need intensive care including anti-platelet and statin therapy for the prevention of coronary plaque rupture.<Learning objective: Triglyceride might be a sensitive biomarker of activated macrophages and plaque vulnerability in patients with RA. RA patients with an abrupt increase in triglyceride might need intensive care including anti-platelet and statin therapy for the prevention of coronary plaque rupture.>
(キーワード): Acute coronary syndrome / Triglyceride / Tumor necrosis factor- / Biomarker
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jccase.2014.04.009
(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-84905378195

(DOI: 10.1016/j.jccase.2014.04.009, Elsevier: Scopus) Hirotsugu Yamada, Kenya Kusunose, S Nishio, Mika Bando, Junko Hotsuchi, S Hayashi, Takayuki Ise, Shusuke Yagi, Koji Yamaguchi, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Pre-load stress echocardiography for predicting the prognosis in mild heart failure.,
JACC. Cardiovascular Imaging, Vol.7, No.7, 641-649, 2014.

(キーワード): Doppler echocardiography / heart failure / leg-positive pressure / stress echocardiography / survival
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jcmg.2014.04.009
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24954460; ● Summary page in Scopus @ Elsevier: 2-s2.0-84904576445

(DOI: 10.1016/j.jcmg.2014.04.009, PubMed: 24954460, Elsevier: Scopus) S Bando, Takeshi Soeki, T Matsuura, Toshiyuki Niki, Takayuki Ise, Koji Yamaguchi, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Masashi Akaike, T Aiba, W Shimizu and Masataka Sata :
Congenital long QT syndrome with compound mutations in the KCNH2 gene.,
Heart and Vessels, Vol.29, No.4, 554-559, 2014.

(要約): Congenital long QT syndrome is a genetic disorder encompassing a family of mutations that can lead to aberrant ventricular electrical activity. We report on two brothers with long QT syndrome caused by compound mutations in the KCNH2 gene inherited from parents who had no prolonged QT interval on electrocardiography. The proband had syncope, and his elder brother suffered from ventricular fibrillation. Genetic testing revealed that both brothers had multiple mutations in the KCNH2 gene, including a missense mutation of C1474T (exon 6) as well as a frameshift/nonsense mutation, resulting from the insertion of 25 nucleotides, which caused an altered amino acid sequence beginning at codon 302 and a premature termination codon (i.e., TAG) at codon 339 (exon 4). Family genetic screening found that their father had the same frameshift mutation, and their mother and sister had the same missense mutation, in the KCNH2 gene. However, these other family members were asymptomatic, with normal QT intervals on electrocardiography. These results suggest that compound mutations in the KCNH2 gene inherited independently from the parents made the phenotypes of their sons more severe.
(キーワード): KCNH2 gene / Long QT syndrome / Compound mutation / Missense mutation / Frameshift mutation
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s00380-013-0406-2
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24057343; ● Summary page in Scopus @ Elsevier: 2-s2.0-84904036858

(DOI: 10.1007/s00380-013-0406-2, PubMed: 24057343, Elsevier: Scopus) S Hayashi, Hirotsugu Yamada, Mika Bando, Junko Hotsuchi, Takayuki Ise, Koji Yamaguchi, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Toshiaki Tamaki and Masataka Sata :
Augmentation Index does not Reflect the Risk of Coronary Artery Disease in Elderly Patients.,
Circulation Journal, Vol.78, No.5, 1176-1182, 2014.

(要約): BACKGROUND: Augmentation index (AI) has been used as a clinical index of arterial stiffness and has been reported to be an independent predictor of cardiovascular events, but some investigators have reported that AI is not a useful marker to identify coronary artery disease (CAD) in elderly patients. The majority of CAD patients are elderly people, therefore the aim of this study was to examine whether AI is a useful marker to identify the risk of CAD.METHODS AND RESULTS: A total of 120 patients (69±10 years of age; 83 male) who underwent cardiac catheterization for suspected CAD were enrolled. Invasive central blood pressure (BP) was measured using a fluid-filled catheter. Non-invasive AI was calculated by the SphygmoCor (AtCor Medical) system at the end of catheterization. Subjects consisted of 99 patients with CAD and 21 patients without CAD. There was no significant difference in AI between the CAD and the non-CAD groups (24±10 vs. 24±14%). Non-invasive systolic central BP was lower than the invasive systolic central BP (115±18 vs. 130±23 mmHg, P<0.001) in all patients. Non-invasive diastolic central BP was greater than the invasive diastolic central BP (67±10 vs. 63±10 mmHg, P<0.001).CONCLUSIONS: In elderly patients, AI may not be a useful marker to identify CAD
(キーワード): Arterial stiffness / Augmentation index / Central blood pressure / Coronary artery disease
(徳島大学機関リポジトリ): ● Metadata: 106070
(出版サイトへのリンク): ● Publication site (DOI): 10.1253/circj.CJ-13-1422
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24562676; ● CiNii @ 国立情報学研究所 (CRID): 1390001205107150592; ● Summary page in Scopus @ Elsevier: 2-s2.0-84899659435

(徳島大学機関リポジトリ: 106070, DOI: 10.1253/circj.CJ-13-1422, PubMed: 24562676, CiNii: 1390001205107150592, Elsevier: Scopus) Takayuki Ise, Takashi Iwase, S Masuda, Shusuke Yagi, Masashi Akaike, S Nishio, Toshiyuki Niki, Koji Yamaguchi, Yoshio Taketani, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Acute pulmonary thromboembolism from deep vein thrombosis induced by trauma to the popliteal vein with a tennis racket.,
Journal of Cardiology Cases, Vol.9, No.4, 162-164, 2014.

(要約): Acute pulmonary thromboembolism (PTE) is mainly caused by deep vein thrombosis (DVT) and sometimes leads to a fatal outcome. Few cases of sport-related lower extremity DVT, involving direct external trauma, have been reported. A 58-year-old man, without any risk factors for thromboembolism suffered acute PTE from DVT after playing tennis. A detailed history revealed that he had hit his popliteal vein with each swing of his tennis racket and the site of the trauma, at popliteal fossa, was exactly the same as the site of the DVT formation. Therefore, the cause of DVT was suspected to be the repeated trauma to the popliteal vein. The repeated external trauma to the popliteal vein may have caused vascular endothelial damage, leading to DVT.
(キーワード): Acute pulmonary thromboembolism / Deep vein thrombosis / Trauma
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jccase.2014.01.001
(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-84897413698

(DOI: 10.1016/j.jccase.2014.01.001, Elsevier: Scopus) Takeshi Soeki, Toshiyuki Niki, E. Uematsu, S. Bando, T. Matsuura, Kenya Kusunose, Takayuki Ise, Yuka Ueda, N. Tomita, Koji Yamaguchi, Kunihiko Koshiba, Shusuke Yagi, Daiju Fukuda, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Masashi Akaike, Michio Shimabukuro, I. Kishimoto, Kenji Kangawa and Masataka Sata :
Ghrelin protects the heart against ischemia-induced arrhythmias by preserving connexin-43 protein.,
Heart and Vessels, Vol.28, No.6, 795-801, 2013.

(要約): Vagal nerve stimulation has been postulated to confer an antifibrillatory effect. We studied whether ghrelin administration would exert an antiarrhythmic effect via modulation of autonomic nerve activity in rats after acute myocardial ischemia (MI). Male Sprague-Dawley rats were exposed to 30 min of ischemia following ligation of the left coronary artery. Animals were then randomized to receive either ghrelin (n = 26) or saline (n = 26) during the period of coronary ligation. Power spectral analysis of heart-rate variability revealed that the administration of ghrelin increased the high-frequency (HF) power and decreased the low-frequency (LF)/HF ratio. Ventricular tachyarrhythmias were less frequent in rats after MI who received ghrelin in comparison with rats that received saline. Immunoblotting and immunohistochemistry revealed that rats given saline alone during MI exhibited a marked reduction in phosphorylated connexin-43 within the left ventricle, whereas those that received ghrelin displayed only minor reductions in comparison with sham-operated rats. These effects of ghrelin were diminished by the coadministration of atropine or the blockade of vagal afferents. These data demonstrate that the beneficial effect of ghrelin might be mediated by modulation of cardiac autonomic nerve activity.
(キーワード): Animals / Anti-Arrhythmia Agents / Atropine / Connexin 43 / Disease Models, Animal / Ghrelin / Heart Rate / Heart Ventricles / Male / Muscarinic Antagonists / Myocardial Ischemia / Phosphorylation / Rats / Rats, Sprague-Dawley / Tachycardia, Ventricular / Time Factors / Vagotomy / Vagus Nerve
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s00380-013-0333-2
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23494606; ● Search Scopus @ Elsevier (PMID): 23494606; ● Search Scopus @ Elsevier (DOI): 10.1007/s00380-013-0333-2

(DOI: 10.1007/s00380-013-0333-2, PubMed: 23494606) Shusuke Yagi, Masashi Akaike, Ken-ichi Aihara, Daiju Fukuda, Masayoshi Ishida, Takayuki Ise, Toshiyuki Niki, Yuka Ueda, Koji Yamaguchi, Takashi Iwase, Yoshio Taketani, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Pharmacology of Aldosterone and the Effects of Mineralocorticoid Receptor Blockade on Cardiovascular Systems.,
Acta Cardiologica Sinica, Vol.29, No.3, 201-207, 2013.

(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-84878307366

(Elsevier: Scopus) Kenya Kusunose, Hirotsugu Yamada, S. Nishio, N. Tomita, Toshiyuki Niki, Koji Yamaguchi, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Interval from the Onset of Transmitral Flow to Annular Velocity Is a Marker of LV Filling Pressure.,
JACC. Cardiovascular Imaging, Vol.6, No.4, 528-530, 2013.

(キーワード): Angina, Stable / Atrial Function, Left / Atrial Pressure / Cardiac Catheterization / Case-Control Studies / Echocardiography, Doppler, Color / Humans / Mitral Valve / Multivariate Analysis / Predictive Value of Tests / Prospective Studies / Time Factors / Ventricular Function, Left / Ventricular Pressure
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jcmg.2012.10.025
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23579016; ● Search Scopus @ Elsevier (PMID): 23579016; ● Search Scopus @ Elsevier (DOI): 10.1016/j.jcmg.2012.10.025

(DOI: 10.1016/j.jcmg.2012.10.025, PubMed: 23579016) M Nakamura, M Yamagishi, T Ueno, K Hara, S Ishiwata, T Itoh, I Hamanaka, Tetsuzo Wakatsuki, T Sugano, K Kawai and T Kimura :
Current antiplatelet therapy for Japanese patients with ST elevation acute myocardial infarction: J-AMI registry.,
Cardiovascular Intervention and Therapeutics, Vol.28, No.2, 162-169, 2013.

(要約): Antiplatelet therapy could prevent stent thrombosis, but may be associated with an increased risk of bleeding. Recent studies have revealed that bleeding complications are relatively frequent in patients with acute coronary syndromes. Our aim was to describe the current status of antiplatelet therapy for Japanese patients with acute myocardial infarction (AMI). The Japan AMI (J-AMI) registry is a prospective observational study that has enrolled 2,030 consecutive patients with stent thrombosis elevation myocardial infarction (STEMI) admitted to 213 participating Japanese institutions. Current antiplatelet therapy for STEMI was assessed, and the occurrence of bleeding complications (based on GUSTO bleeding criteria) and stent thrombosis was also evaluated. Additionally, the clinical course after bleeding episodes was investigated. Percutaneous coronary intervention (PCI) was done in 97.2 % of the patients, using a drug-eluting stent in 30 % and a bare metal stent in 63 % of PCI cases. A 300-mg loading dose of clopidogrel followed by its administration at 75 mg/day with aspirin was the current standard treatment for Japanese STEMI patients. In-hospital bleeding complications occurred in 1.9 %, especially in patients with severe clinical features or a history of cerebrovascular disease. Moderate to severe bleeding complications were associated with 10 deaths. The in-hospital stent thrombosis (ST) rate was 1.47 %, and loading with clopidogrel prior to PCI was significantly less frequent in patients who developed ST (P < 0.001). In conclusion, the J-AMI registry revealed that severe symptoms of STEMI increased the risk of bleeding, while delay of clopidogrel loading was associated with ST. These findings suggest the need for treatment based on risk stratification to improve the balance between the beneficial and adverse effects of antiplatelet therapy in Japanese STEMI patients.
(キーワード): Acute myocardial infarction / Stent thrombosis / Bleeding complication / Antiplatelet treatment
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s12928-012-0146-8
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1007/s12928-012-0146-8

(DOI: 10.1007/s12928-012-0146-8) Tomoya Hara, Hirotsugu Yamada, Akira Takashima, Hiromu Yamasaki, Kozue Ogasawara, Sachiko Bando, Takayuki Ise, Toshiyuki Niki, Kenya Kusunose, Yuka Ueda, Noriko Tomita, Koji Yamaguchi, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Hidehisa Horiguchi, Naomi Sakashita and Masataka Sata :
Constrictive pericarditis with intrapericardial abscess.,
Circulation Journal, Vol.77, No.3, 786-788, 2013.

(キーワード): Abscess / Aged / Autopsy / Fatal Outcome / Heart Diseases / Humans / Male / Methicillin-Resistant Staphylococcus aureus / Pericarditis, Constrictive / Pericardium / Staphylococcal Infections
(出版サイトへのリンク): ● Publication site (DOI): 10.1253/circj.CJ-12-1098
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23207988; ● Summary page in Scopus @ Elsevier: 2-s2.0-84874412877

(DOI: 10.1253/circj.CJ-12-1098, PubMed: 23207988, Elsevier: Scopus) N. Kawano, Koji Yamaguchi, Toshiyuki Niki, Yamamoto Takashi, Takashi Iwase, Yoshio Taketani, Takayuki Ise, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, K Kawano, A. Kakutani and Masataka Sata :
Two cases of acute myocardial infarction during combined chemotherapy in young patients with testicular cancer.,
Journal of Cardiology Cases, Vol.7, No.6, e176-e180, 2013.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jccase.2013.02.009
(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-84877831795

(DOI: 10.1016/j.jccase.2013.02.009, Elsevier: Scopus) 高島啓, 伊勢孝之, 上田由佳, 岩瀬俊, 八木秀介, 前田香代子, 西川幸治, 小笠原梢, 坂東美佳, 坂東左知子, 冨田紀子, 仁木敏之, 發知淳子, 山口浩司, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 加藤真介, 赤池雅史, 安井夏生, 佐田政隆 :
心臓リハビリテーションは酸化LDLを低下させる,
心臓リハビリテーション, Vol.18, No.1, 130-133, 2013年.

(キーワード): 酸化LDL / 心臓リハビリテーション / 心肺運動負荷試験
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1520010381154583040

(CiNii: 1520010381154583040) T Hara, Koji Yamaguchi, Takashi Iwase, M Kadota, Mika Bando, K Ogasawara, S Bando, Takayuki Ise, Toshiyuki Niki, Yuka Ueda, N Tomita, Yoshio Taketani, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Eosinophilic Myocarditis due to Churg-Strauss syndrome with markedly elevated Eosinophil Cationic Protein.,
International Heart Journal, Vol.54, No.1, 51-53, 2013.

(要約): A 67-year-old woman with asthma visited our hospital with increasing dyspnea and new-onset paresthesia and purpura in her legs. Physical examination showed a wheeze, pretibial edema, and surrounding purpura. Chest X-rays showed cardiac decompensation and an electrocardiogram revealed a new ST-T change. Laboratory data showed leukocytosis, hypereosinophilia (10,450/μL), troponin T(+), elevated BNP, and markedly elevated eosinophil cationic protein (ECP) (> 150 ng/mL). Echocardiography revealed diffuse left ventricular hypokinesis (ejection fraction 30%) with increased wall thickness. Coronary angiography was normal. Cardiac magnetic resonance imaging implied diffuse myocardial edema and subendocardial late gadolinium enhancement. Skin biopsy of purpura showed superfi cial perivascular dermatitis with remarkable eosinophilic infiltrations. No evidence of drug allergies, parasitic infection, or myeloproliferative disorder was detected. Based on these findings, a diagnosis of eosinophilic myocarditis due to Churg-Strauss syndrome was considered. She was administered prednisolone at a dose of 1 mg/kg, cyclophosphamide, and diuretics. Several markers of eosinophilic myocarditis and heart failure gradually improved, including ECP. She was discharged 30 days later with no cardiac event. Eosinophilic myocarditis is characterized by predominantly eosinophilic infi ltration. Eosinophilic granule proteins, such as ECP and major basic protein, play important roles in the pathogenesis of eosinophilic myocarditis. We experienced a rare case of eosinophilic myocarditis due to Churg-Strauss syndrome. Markedly elevated ECP played an important role in the early diagnosis and subsequent reduction in ECP served as a marker of monitoring. In an asthmatic patient with dyspnea, hypereosinophilia, and vasculitis, Churg-Strauss syndrome with eosinophilic myocarditis should be considered.
(出版サイトへのリンク): ● Publication site (DOI): 10.1536/ihj.54.51
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23428926; ● Search Scopus @ Elsevier (PMID): 23428926; ● Search Scopus @ Elsevier (DOI): 10.1536/ihj.54.51

(DOI: 10.1536/ihj.54.51, PubMed: 23428926) T. Hara, Tetsuzo Wakatsuki, Yoshio Taketani, Koji Yamaguchi, Takashi Iwase and Masataka Sata :
A case of successful use of microsnare to hold and pull the retrograde guidewire for the intervention to peripheral chronic total occlusion.,
Cardiovascular Intervention and Therapeutics, Vol.28, No.3, 287-290, 2013.

(要約): A basket-shaped microsnare has various uses such as the pull through technique during coronary intervention to chronic total occlusion (CTO). A 79-year-old man underwent angioplasty for the femoral artery occlusion. We performed a controlled antegrade and retrograde tracking (CART) with dilatation of a balloon on the antegrade guidewire. The retrograde guidewire partly ran in the true lumen but could not pass through the CTO lesion because of inadequate CART. Eventually, we successfully gripped the top of the retrograde guidewire in the CTO lesion using the basket-shaped microsnare (Soutenir(®)). The microsnare may be useful for bidirectional approach in peripheral CTO lesions.
(キーワード): Microsnare / Chronic total occlusions / Peripheral intervention
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s12928-013-0158-z
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1522543655127492352; ● Search Scopus @ Elsevier (DOI): 10.1007/s12928-013-0158-z

(DOI: 10.1007/s12928-013-0158-z, CiNii: 1522543655127492352) M Nakamura, M Yamagishi, T Ueno, K Hara, S Ishiwata, T Itoh, I Hamanaka, Tetsuzo Wakatsuki, T Sugano, K Kawai and T Kimura :
Current treatment of ST elevation acute myocardial infarction in Japan: door-to-balloon time and total ischemic time from the J-AMI registry,
Cardiovascular Intervention and Therapeutics, Vol.28, No.1, 30-36, 2013.

(要約): The door-to-balloon time and total ischemic time are important predictors of the outcome in patients with ST elevation myocardial infarction (STEMI) receiving primary angioplasty, but the current situation in Japan is unknown. The Japan Acute Myocardial Infarction registry is a prospective observational study of 2,030 consecutive STEMI patients admitted to 213 Japanese institutions. The time from symptom onset to hospital arrival, door-to-balloon time, and in-hospital outcome were assessed. Data were compared between patients treated during regular hours or after hours. Percutaneous coronary angioplasty was done in 97.2 % of the patients, using drug-eluting stents in 30 % and bare metal stents in 63 % of the treated cases. The median symptom onset-to-door time (25th and 75th percentiles) was 135 min (64305 min), median door-to-balloon time was 42 min (2866 min), and mean procedural time was 98 ± 51 min. The on-call catheterization team performed 48.5 % of the procedures. There was no significant difference of door-to-balloon time between the patients treated after hours and those treated during regular hours. The cardiac mortality rate was 3.2 %, and it increased with longer door-to-balloon times (P = 0.03). The relationship between total ischemic time and cardiac mortality showed 2 peaks, with a trough at 5 h. Median door-to-balloon time was <90 min and was not longer in after hours cases. These findings suggest that Japanese institutions can provide primary angioplasty within an acceptable time frame.
(キーワード): AMI / Angioplasty / Door-to-balloon time / Total ischemic time
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s12928-012-0128-x
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1007/s12928-012-0128-x

(DOI: 10.1007/s12928-012-0128-x) Munkhbaatar Dagvasumberel, Michio Shimabukuro, Nishiuchi Takeshi, Junji Ueno, Shoichiro Takao, Daiju Fukuda, Hirata Yoichiro, Hirotsugu Kurobe, Takeshi Soeki, Takashi Iwase, Kenya Kusunose, Toshiyuki Niki, Koji Yamaguchi, Yoshio Taketani, Shusuke Yagi, Tomita Noriko, Hirotsugu Yamada, Tetsuzo Wakatsuki, Masafumi Harada, Tetsuya Kitagawa and Masataka Sata :
Gender disparities in the association between epicardial adipose tissue volume and coronary atherosclerosis: A 3-dimensional cardiac computed tomography imaging study in Japanese subjects.,
Cardiovascular Diabetology, Vol.11, No.1, 106, 2012.

(要約): Growing evidence suggests that epicardial adipose tissue (EAT) may contribute to the development of coronary artery disease (CAD). In this study, we explored gender disparities in EAT volume (EATV) and its impact on coronary atherosclerosis. The study population consisted of 90 consecutive subjects (age: 63 ± 12 years; men: 47, women: 43) who underwent 256-slice multi-detector computed tomography (MDCT) coronary angiography. EATV was measured as the sum of cross-sectional epicardial fat area on CT images, from the lower surface of the left pulmonary artery origin to the apex. Subjects were segregated into the CAD group (coronary luminal narrowing > 50%) and non-CAD group. EATV/body surface area (BSA) was higher among men in the CAD group than in the non-CAD group (62 ± 13 vs. 33 ± 10 cm3/m2, p < 0.0001), but did not differ significantly among women in the 2 groups (49 ± 18 vs. 42 ± 9 cm3/m2, not significant). Multivariate logistic analysis showed that EATV/BSA was the single predictor for >50% coronary luminal narrowing in men (p < 0.0001). Predictors excluded were age, body mass index, hypertension, diabetes mellitus, and hyperlipidemia. Increased EATV is strongly associated with coronary atherosclerosis in men.
(キーワード): Adipose Tissue / Age Factors / Aged / Asian Continental Ancestry Group / Body Surface Area / Chi-Square Distribution / Coronary Angiography / Coronary Artery Disease / Coronary Stenosis / Female / Health Status Disparities / Humans / Japan / Logistic Models / Male / Middle Aged / Multidetector Computed Tomography / Multivariate Analysis / Pericardium / Predictive Value of Tests / Risk Assessment / Risk Factors / Severity of Illness Index / Sex Factors
(出版サイトへのリンク): ● Publication site (DOI): 10.1186/1475-2840-11-106
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22963346; ● Search Scopus @ Elsevier (PMID): 22963346; ● Search Scopus @ Elsevier (DOI): 10.1186/1475-2840-11-106

(DOI: 10.1186/1475-2840-11-106, PubMed: 22963346) Kenya Kusunose, Hirotsugu Yamada, Susumu Nishio, Noriko Tomita, Junko Hotchi, Mika Bando, Toshiyuki Niki, Koji Yamaguchi, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Index-beat Assessment of Left Ventricular Systolic and Diastolic Function during Atrial Fibrillation using Myocardial Strain and Strain Rate.,
Journal of the American Society of Echocardiography, Vol.25, No.9, 953-959, 2012.

(要約): Accurate assessment of left ventricular (LV) function in patients with atrial fibrillation (AF) remains difficult, mainly because of the beat-to-beat variability of many echocardiographic parameters. The aim of this study was to assess the hypothesis that LV function can be estimated from an index-beat echocardiographic assessment in patients with AF using myocardial strain and strain rate. A prospective study was conducted to assess 25 patients with AF (mean age, 66 ± 10 years). Peak systolic longitudinal strain (LS) and peak diastolic longitudinal strain rate (dSR) were measured using two different methods: (1) mean LS and dSR, the averages of instantaneous LS and dSR over 10 sec, and (2) index-beat LS and dSR, calculated when the ratio of the preceding (RR1) to the pre-preceding (RR2) interval was 1 (range, 0.96-1.04). These variables were compared with simultaneously measured LV pressure parameters using Millar catheters. There was a positive linear relationship between mean LS and index-beat LS at RR1/RR2 = 1 (r = 0.94, P < .001) and a positive linear relationship between mean dSR and index-beat dSR (r = 0.69, P < .001). Index-beat LS was correlated with the maximal positive derivative of LV pressure (peak +dP/dt) (r = -0.73, P < .001). Index-beat dSR was correlated with the time constant of isovolumic LV pressure decay (τ) (r = -0.63, P < .001). To investigate the independent predictors of τ, a stepwise multilinear regression analysis showed that index-beat dSR was the best predictor of τ. Index-beat parameters accurately reflect the mean values of parameters in patients with AF. These noninvasively obtained index-beat parameters are useful to assess surrogate LV function even in patients with AF.
(キーワード): Aged / Atrial Fibrillation / Diastole / Echocardiography, Doppler / Female / Heart Rate / Hemodynamics / Humans / Male / Myocardial Contraction / Prospective Studies / Regression Analysis / Reproducibility of Results / Systole
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.echo.2012.06.009
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22763085; ● Search Scopus @ Elsevier (PMID): 22763085; ● Search Scopus @ Elsevier (DOI): 10.1016/j.echo.2012.06.009

(DOI: 10.1016/j.echo.2012.06.009, PubMed: 22763085) T. Hara, Takeshi Soeki, Toshiyuki Niki, Kenya Kusunose, Koji Yamaguchi, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Tetsuzo Wakatsuki and Masataka Sata :
Bicuspid aortic valve endocarditis complicated by perivalvular abscess.,
The Journal of Medical Investigation : JMI, Vol.59, No.3,4, 261-265, 2012.

(要約): A 37-year-old man presenting with fever and chest pain was admitted to our hospital. Electrocardiogram showed sinus tachycardia and complete left bundle branch block. Transthoracic echocardiogram showed infective endocarditis in the bicuspid aortic valve, complicated by multiple hyperechoic vegetations and severe aortic regurgitation. Blood cultures were negative and intravenous empiric antibiotic therapy was begun. However, fever lasted for 7 days and follow-up echocardiography revealed a newly emerged perivalvular abscess. The patient eventually underwent an urgent aortic root replacement that confirmed the echocardiographic findings. Our case report emphasizes that all patients with suspected aortic valve endocarditis should undergo early and follow-up echocardiographic studies.
(キーワード): bicuspid aortic valve / infectious endocarditis / perivalvular abscess / echocardiography
(徳島大学機関リポジトリ): ● Metadata: 106030
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.59.261
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23037197; ● Search Scopus @ Elsevier (PMID): 23037197; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.59.261

(徳島大学機関リポジトリ: 106030, DOI: 10.2152/jmi.59.261, PubMed: 23037197) 坂東美佳, 山田博胤, 西尾進, 玉井利奈, 平田有紀奈, 弘田大智, 中川摩耶, 林修司, 冨田紀子, 發知淳子, 小笠原梢, 高島啓, 山崎宙, 坂東左知子, 伊勢孝之, 仁木敏之, 上田由佳, 山口浩司, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 佐田政隆, 兼松康久, 里見淳一郎, 永廣信治 :
脂質低下療法による頸動脈プラーク安定化の評価:超音波integrated backscatterを用いたカラーマッピングシステムの開発と臨床応用症例報告 (第28回徳島医学会賞受賞論文),
四国医学雑誌, Vol.68, No.3-4, 147-152, 2012年.

(要約): Background : The carotid plaque vulnerability is related to myocardial and cerebral infarction.We intended to develop an imaging system which enables to visualize tissue characteristics in thecarotid plaques based on ultrasound integrated backscatter(IB). And to test its clinical efficacy,effect of the statin therapy on the plaques was evaluated with our software. Methods and Results :Carotid ultrasound examination was performed and ultrasonographic RAW data of the plaqueswere obtained from8patients undergoing carotid artery endarterectomy. Tissue characteristicsin the plaques of resected examples were compared with preoperative ultrasonic images and thetissue IB values corresponding to the specimens were determined for developing our imaging system.Using this system, Color-coded maps of plaques in the three patients were constructed beforeand after lipid lowing therapy. We could demonstrate that lipid fraction in each plaque decreasedand fibrous or calcification fraction increased in the follow-up study. Conclusions : Changes inhistology of carotid plaques by statin could visualized with our imaging system. This techniquemay become a useful tool for the management of atherosclerosis.
(キーワード): IBS (integrated backscatter) / carotid plaque / CEA (carotid endarterectomy)
(徳島大学機関リポジトリ): ● Metadata: 102836
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1050302172854564352

(徳島大学機関リポジトリ: 102836, CiNii: 1050302172854564352) Takeshi Soeki, Mitsuhiro Kitani, Kenya Kusunose, Shusuke Yagi, Yoshio Taketani, Kunihiko Koshiba, Tetsuzo Wakatsuki, Shunsuke Orino, Kazuhiro Kawano and Masataka Sata :
Renoprotective and antioxidant effects of cilnidipine in hypertensive patients.,
Hypertension Research, Vol.35, No.11, 1058-1062, 2012.

(要約): Cilnidipine, an L/N-type calcium channel blocker (CCB), has been reported to have more beneficial effects on proteinuria progression in hypertensive patients than amlodipine, an L-type CCB. The N-type calcium channel blockade that inhibits renal sympathetic nerve activity might reduce glomerular hypertension by facilitating vasodilation of the efferent arterioles. However, the precise mechanism of the renoprotective effect of cilnidipine remains unknown. Because cilnidipine exerted significantly higher antioxidant activity than amlodipine in cultured human mesangial cells, we hypothesized that cilnidipine might exert a renoprotective effect by suppressing oxidative stress. A total of 35 hypertensive patients receiving a renin-angiotensin system inhibitor were randomly assigned to a cilnidipine (n=18; 10 mg per day cilnidipine titrated to 20 mg per day) or amlodipine (n=17; 5 mg per day amlodipine titrated to 10 mg per day) group; the target blood pressure (BP) was set at 130/85 mmHg. After 6 months of treatment, systolic and diastolic BPs were significantly reduced in both of the groups, without any significant difference between the groups. The urinary albumin, 8-hydroxy-2'-deoxyguanosine (OHdG) and liver-type fatty-acid-binding protein (L-FABP) to creatinine ratios significantly decreased in the cilnidipine group (P<0.05) compared with those in the amlodipine group. The reductions in urinary albumin, 8-OHdG and L-FABP were not correlated with the change in systolic BP. In conclusion, cilnidipine, but not amlodipine, ameliorated urinary albumin excretion and decreased urinary 8-OHdG and L-FABP in the hypertensive patients. Cilnidipine probably exerts a greater renoprotective effect through its antioxidative properties.Hypertension Research advance online publication, 5 July 2012; doi:10.1038/hr.2012.96.
(出版サイトへのリンク): ● Publication site (DOI): 10.1038/hr.2012.96
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22763473; ● Search Scopus @ Elsevier (PMID): 22763473; ● Search Scopus @ Elsevier (DOI): 10.1038/hr.2012.96

(DOI: 10.1038/hr.2012.96, PubMed: 22763473) 久岡白陽花, 上田由佳, 前田香代子, 西川幸治, 坂東左知子, 林修司, 竹内秀和, 仁木敏之, 楠瀬賢也, 山口浩司, 冨田紀子, 岩瀬俊, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 髙田信二郎, 赤池雅史, 安井夏生, 佐田政隆 :
(若手優秀演題セッション)尿中アルブミン排泄量に及ぼす心臓リハビリテーションの効果,
心臓リハビリテーション, Vol.17, No.1, 159-161, 2012年. Koji Yamaguchi, Tetsuzo Wakatsuki, Toshiyuki Niki, Kenya Kusunose, Kunihiko Koshiba, Shusuke Yagi, Yoshio Taketani, Takashi Iwase, Noriko Tomita, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Local persistent hypercoagulability after sirolimus-eluting stent implantation in patients with stable angina.,
International Journal of Cardiology, Vol.153, No.3, 272-276, 2011.

(要約): Late stent thrombosis (LST) after sirolimus-eluting stent (SES) implantation has been demonstrated previously. Although incomplete neointimal coverage after SES implantation has been reported, local long-term hypercoagulability remains unknown. We evaluated the local persistent coagulative response in eighty-three consecutive patients with stable angina, treated with either SES (n=51) or BMS (n=32) implantation for isolated de novo left anterior descending (LAD) stenosis. We measured prothrombin fragment F1+2 (frF1+2) and D-dimer levels sampled in the coronary sinus (CS) and sinus of Valsalva (V). The transcardiac gradient (Δ) was defined as the CS level minus V level. The ΔfrF1 + 2 and ΔD-dimer were significantly greater in the SES group than in the BMS group (0.50 ± 0.35 vs -0.14 ± 0.15 nmol/l, p=0.009 and 0.24 ± 0.21 vs -0.05 ± 0.16 μg/ml, p=0.041, respectively). We selected the hypocoagulative [ΔfrF1 + 2<0.15 (mean value-SD) nmol/l, n=21] and hypercoagulative [ΔfrF1 + 2>0.85 (mean value+SD) nmol/l, n=14] groups out of the SES patients. Multivariate analysis was performed to identify independent predictors of local hypercoagulability. Total SES length was the only independent predictor of local hypercoagulability. There was a significant positive correlation between the ΔfrF1 + 2 and total stent length in the SES group (r=0.57, p<0.05). An increased local coagulative response was observed in the convalescent phase after SES implantation as compared to BMS. Careful long-term follow-up of patients after longer SES implantation is recommended in order to avoid LST.
(キーワード): Aged / Angina, Stable / Cohort Studies / Coronary Thrombosis / Drug-Eluting Stents / Female / Humans / Male / Middle Aged / Sirolimus / Thrombophilia / Time Factors
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.ijcard.2010.08.014
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20826025; ● Search Scopus @ Elsevier (PMID): 20826025; ● Search Scopus @ Elsevier (DOI): 10.1016/j.ijcard.2010.08.014

(DOI: 10.1016/j.ijcard.2010.08.014, PubMed: 20826025) Hiromu Yamazaki, Koji Yamaguchi, Takashi Iwase, Toshiyuki Niki, Kenya Kusunose, Noriko Tomita, Yoshio Taketani, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Yutaka Fukunaga, Hideki Nakanishi, Haruhiko Maruyama, Hiroyuki Matsuoka and Masataka Sata :
A patient who developed toe necrosis due to poor blood circulation after an interdigital tick bite.,
Journal of Cardiology Cases, Vol.4, No.2, e106-e109, 2011.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jccase.2011.06.005
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1016/j.jccase.2011.06.005

(DOI: 10.1016/j.jccase.2011.06.005) Takeshi Soeki, Toshiyuki Niki, Kenya Kusunose, Sachiko Bando, Yoichiro Hirata, Noriko Tomita, Koji Yamaguchi, Kunihiko Koshiba, Shusuke Yagi, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Elevated concentrations of pentraxin 3 are associated with coronary plaque vulnerability.,
Journal of Cardiology, Vol.58, No.2, 151-157, 2011.

(要約): Inflammation is a critical contributing factor to the development and progression of atherosclerosis. Pentraxin 3 (PTX3) is produced abundantly in atherosclerotic lesions while C-reactive protein (CRP) is mainly produced in the liver. In this study, we investigated whether plasma levels of PTX3 might be a sensitive marker both for the severity of coronary artery disease and vulnerable plaques. Next, we determined whether assays for inflammatory molecules can be used to monitor the therapeutic effects of telmisartan on stabilization of vulnerable atherosclerotic plaques. We measured PTX3 concentrations in the peripheral and coronary sinus plasma of 40 patients with angina pectoris (AP) and 20 control subjects. Next, in 28 patients with AP, we determined the correlation between levels of inflammatory molecules and the computed tomography (CT) density of plaques as a quantitative index of plaque vulnerability. There was no significant difference in peripheral plasma PTX3 concentrations between patients with AP and control subjects, while coronary sinus plasma PTX3 concentrations were significantly higher in AP patients than control subjects. The concentrations of PTX3 in coronary sinus and peripheral plasma correlated with Gensini scores as an index of severity of coronary atherosclerosis. Interestingly, there was a significantly negative correlation between plasma PTX3 concentrations and CT density (r=-0.67, p<0.01). On the other hand, CT density did not correlate with the peripheral plasma concentrations of monocyte chemoattractant protein-1 (MCP-1) or high-sensitivity CRP (hsCRP). Furthermore, telmisartan treatment for 6 months decreased plasma concentrations of PTX3 but not those of MCP-1 or hsCRP in 12 patients with essential hypertension. Multivariate regression analysis revealed that changes in PTX3 levels were independent of blood pressure changes. PTX3 is likely more specific than hsCRP as an indicator of coronary plaque vulnerability that could lead to plaque rupture.
(キーワード): Aged / Angina Pectoris / Angiotensin II Type 1 Receptor Blockers / Benzimidazoles / Benzoates / Biological Markers / C-Reactive Protein / Coronary Artery Disease / Coronary Sinus / Disease Progression / Drug Monitoring / Female / Humans / Inflammation Mediators / Male / Middle Aged / Plaque, Atherosclerotic / Serum Amyloid P-Component / Severity of Illness Index / Tomography, Spiral Computed
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jjcc.2011.04.005
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21676590; ● Search Scopus @ Elsevier (PMID): 21676590; ● Search Scopus @ Elsevier (DOI): 10.1016/j.jjcc.2011.04.005

(DOI: 10.1016/j.jjcc.2011.04.005, PubMed: 21676590) Toshiyuki Niki, Tetsuzo Wakatsuki, Koji Yamaguchi, Kenya Kusunose, Kunihiko Koshiba, Shusuke Yagi, Yoshio Taketani, Takashi Iwase, Noriko Tomita, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Comparison of chronic-stage histopathological findings among 3 coronary stents implanted in the same patient.,
International Journal of Cardiology, Vol.150, No.1, e25-e27, 2011.

(要約): A 73-year-old woman suffering from anterior thoracic pain on exertion presented to our hospital. We performed coronary angiography and noted three stenotic legions in each coronary artery. For each angiographic finding, we implanted a bare metal stent (BMS), sirolimus-eluting stent (SES) and paclitaxel-eluting stent (PES) into the right coronary artery, left anterior descending and left circumflex coronary arteries, respectively. Nine months later, she died of lung disease, and we could compare the histopathological findings among the three coronary stents. In the drug-eluting stents, very thin intima, infiltration of inflammatory cells, and fibrin deposition were observed, while thick intima and no inflammatory findings were observed in the BMS. Fibrin deposition was more marked in the PES than in the SES. This report shows marked differences in the subsequent pathological course among three stents in the same patient.
(キーワード): Aged / Coronary Stenosis / Drug-Eluting Stents / Female / Humans / Paclitaxel / Sirolimus / Stents
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.ijcard.2009.08.032
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19735952; ● Search Scopus @ Elsevier (PMID): 19735952; ● Search Scopus @ Elsevier (DOI): 10.1016/j.ijcard.2009.08.032

(DOI: 10.1016/j.ijcard.2009.08.032, PubMed: 19735952) M Bando, Takeshi Soeki, Toshiyuki Niki, Kenya Kusunose, N Tomita, Koji Yamaguchi, Kunihiko Koshiba, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Ventricular tachycardia in cardiac sarcoidosis controlled by radiofrequency catheter ablation.,
Internal Medicine, Vol.50, No.11, 1201-1206, 2011.

(要約): We report a case of a 78-year-old woman with cardiac sarcoidosis with a history of syncope and palpitation. Further assessment with echocardiography, gadolinium-enhanced cardiovascular magnetic resonance (CMR) and histology led to a diagnosis of cardiac sarcoidosis. As the patient suffered from ventricular tachycardia (VT) despite active corticosteroid therapy, an implantable cardioverter-defibrillator (ICD) was positioned. She was also administered a beta blocker, but an electrical storm appeared every several days requiring ICD therapy. The drug-refractory VT was finally controlled with a catheter ablation session, during which we could detect the VT focus in the right ventricular outflow tract next to the aneurysm by using an electroanatomic mapping system (CARTO). Referring to echocardiographic and CMR images proved very useful in detecting the aneurysm using the CARTO system.
(キーワード): Adrenergic beta-Antagonists / Aged / Catheter Ablation / Comorbidity / Defibrillators, Implantable / Female / Humans / Magnetic Resonance Imaging / Sarcoidosis / Tachycardia, Ventricular / Treatment Failure / Treatment Outcome
(出版サイトへのリンク): ● Publication site (DOI): 10.2169/internalmedicine.50.4580
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21628935; ● Search Scopus @ Elsevier (PMID): 21628935; ● Search Scopus @ Elsevier (DOI): 10.2169/internalmedicine.50.4580

(DOI: 10.2169/internalmedicine.50.4580, PubMed: 21628935) Kenya Kusunose, Hirotsugu Yamada, Noriko Tomita, Susumu Nishio, Toshiyuki Niki, Koji Yamaguchi, Kunihiko Koshiba, Shusuke Yagi, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Serial imaging changes during treatment of Takayasu arteritis with pulmonary artery stenosis.,
International Journal of Cardiology, Vol.148, No.3, 47-50, 2011.

(要約): Most cases of chronic stenosis or occlusive lesions of the pulmonary arteries are attributed to thromboembolism, and pulmonary arteritis is extremely rare as the primary cause of these entities. We report a case of pulmonary stenosis and occlusion caused by Takayasu arteritis. The patient was a 54-year-old woman who presented with dyspnea. Total occlusion of the left pulmonary artery and significant stenosis of the right pulmonary artery caused by Takayasu arteritis were confirmed by various imaging modalities including pulmonary angiography, (18)fluorodeoxyglucose-positron emission tomography, magnetic resonance imaging and real-time three-dimensional transesophageal echocardiography. After 6 weeks of steroid therapy, follow-up imaging studies showed that the stenotic lesion had resolved.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.ijcard.2009.02.036
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19299026; ● Search Scopus @ Elsevier (PMID): 19299026; ● Search Scopus @ Elsevier (DOI): 10.1016/j.ijcard.2009.02.036

(DOI: 10.1016/j.ijcard.2009.02.036, PubMed: 19299026) Shusuke Yagi, Masashi Akaike, Takashi Iwase, Kenya Kusunose, Toshiyuki Niki, Koji Yamaguchi, Kunihiko Koshiba, Yoshio Taketani, Noriko Tomita, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Acute hemodynamic effects of adaptive servo ventilation in patients with pulmonary hypertension.,
International Journal of Cardiology, Vol.148, No.1, 125-127, 2011.

(キーワード): Aged / Aged, 80 and over / Female / Hemodynamics / Humans / Hypertension, Pulmonary / Intermittent Positive-Pressure Ventilation / Male / Middle Aged / Time Factors
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.ijcard.2011.01.074
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21334081; ● Search Scopus @ Elsevier (PMID): 21334081; ● Search Scopus @ Elsevier (DOI): 10.1016/j.ijcard.2011.01.074

(DOI: 10.1016/j.ijcard.2011.01.074, PubMed: 21334081) Shusuke Yagi, Masashi Akaike, Ken-ichi Aihara, Takashi Iwase, Kazue Ishikawa, Sumiko Yoshida, Yuka Sumitomo-Ueda, Kenya Kusunose, Toshiyuki Niki, Koji Yamaguchi, Kunihiko Koshiba, Yoshio Taketani, Noriko Tomita, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Toshio Matsumoto and Masataka Sata :
Effect of low-dose (1 mg/day) pitavastatin on left ventricular diastolic function and albuminuria in patients with hyperlipidemia.,
The American Journal of Cardiology, Vol.107, No.11, 1644-1649, 2011.

(要約): The aim of the present study was to evaluate the factors that modulate the protective action of statins on cardiorenal function, regardless of the lipid-lowering effect. To treat abnormal serum lipid profiles, low-dose pitavastatin (1.0 mg/day) was administered to 65 hyperlipidemic patients. The exclusion criteria included left ventricular ejection fraction <40% and apparent renal disease. Age- and gender-matched patients with hyperlipidemia (n = 40) served as the controls. After 12 to 16 weeks of pitavastatin treatment, pitavastatin had decreased low-density lipoprotein cholesterol (from 143.5 ± 31.4 to 98.2 ± 19.4 mg/dl, p <0.01), triglycerides (from 157.7 ± 57.2 to 140.5 ± 60.7 mg/dl, p <0.01), E/e' (from 10.8 ± 6.2 to 9.0 ± 4.5, p <0.05), a parameter of left ventricular diastolic function, and albuminuria (from 47.6 ± 55.9 to 28.5 ± 40.0 mg/g creatinine, p <0.01). Furthermore, pitavastatin decreased serum transforming growth factor-1 (from 709 ± 242 to 550 ± 299 pg/ml, p <0.01), urinary 8-hydroxy-2'-deoxyguanosine (from 6.6 ± 4.1 to 5.0 ± 3.1 g/g creatinine, p <0.01), an oxidative stress marker, and increased urinary nitrate and nitrite (from 22.5 ± 14.6 to 29.4 ± 27.6 nmol/g creatinine, p <0.05). No such changes were observed in the controls. Multiple regression analysis in the pitavastatin group revealed the effect of pitavastatin on cardiorenal function was associated with suppression of oxidative stress, but not on low-density lipoprotein cholesterol reduction. In conclusion, pitavastatin decreases E/e' and albuminuria, which is associated with suppression of oxidative stress.
(キーワード): Aged / Albuminuria / Case-Control Studies / Cholesterol, LDL / Diastole / Female / Humans / Hydroxymethylglutaryl-CoA Reductase Inhibitors / Hyperlipidemias / Male / Middle Aged / Quinolines / Treatment Outcome / Triglycerides / Ventricular Function, Left
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.amjcard.2011.01.054
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21458773; ● Search Scopus @ Elsevier (PMID): 21458773; ● Search Scopus @ Elsevier (DOI): 10.1016/j.amjcard.2011.01.054

(DOI: 10.1016/j.amjcard.2011.01.054, PubMed: 21458773) Kenya Kusunose, Tetsuzo Wakatsuki and Masataka Sata :
Removal of pinched-off central venous catheter.,
Heart Asia, Vol.3, 32, 2011.

(出版サイトへのリンク): ● Publication site (DOI): 10.1136/ha.2009.001321
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27325978; ● Search Scopus @ Elsevier (PMID): 27325978; ● Search Scopus @ Elsevier (DOI): 10.1136/ha.2009.001321

(DOI: 10.1136/ha.2009.001321, PubMed: 27325978) Koji Yamaguchi, Tetsuzo Wakatsuki, Toshiyuki Niki, Yoshio Taketani, H. Oezuka, Kenya Kusunose, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Observation of short-term atorvastatin-induced changes in coronary arterial plaque properties using integrated backscatter intravascular ultrasound in a patient.,
Journal of Cardiology Cases, Vol.3, No.3, e111-e114, 2011.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jccase.2011.03.007
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1016/j.jccase.2011.03.007

(DOI: 10.1016/j.jccase.2011.03.007) Kenya Kusunose, Hirotsugu Yamada, Susumu Nishio, Yukio Mizuguchi, Masahito Choraku, Yasuhiro Maeda, Shinobu Hosokawa, Nobuo Yamazaki, Noriko Tomita, Toshiyuki Niki, Koji Yamaguchi, Kunihiko Koshiba, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Validation of longitudinal peak systolic strain by speckle tracking echocardiography with visual assessment and myocardial perfusion SPECT in patients with regional asynergy.,
Circulation Journal, Vol.75, No.1, 141-147, 2011.

(要約): Automated function imaging (AFI) is a recently developed method of calculating the longitudinal peak systolic strains (LS) of the regional left ventricular (LV) wall using speckle tracking echocardiography and displaying them on a single bull's-eye map. The feasibility of AFI in patients with regional LV wall motion abnormalities caused by myocardial infarction (MI) was evaluated by comparison with visual assessment and myocardial perfusion single-photon emission computed tomography (SPECT). Segmental LS was measured by AFI in 60 patients with MI (67 ± 11 years) and 58 controls (71 ± 9 years). Wall thickening (WT) was measured by SPECT in 20 patients with MI. There was a strong positive linear relationship between the wall motion score index by expert visual assessment and global LS. The receiver-operating characteristic analysis revealed the best cutoff value of 11% < LS to identify hypokinetic segments. The overall accuracy of wall motion scoring by LS in the 2,006 segments was 96.8% (κ = 0.90) compared with visual assessment. The correlation coefficient between LS and WT was R² = 0.65 in the 340 segments. Assessment of LV regional asynergy by AFI showed good agreement with visual and SPECT assessments. AFI is clinically useful for quantitative assessment of LV regional wall motion abnormalities.
(キーワード): Aged / Aged, 80 and over / Algorithms / Case-Control Studies / Echocardiography, Doppler / Feasibility Studies / Humans / Image Interpretation, Computer-Assisted / 日本 (Japan) / Middle Aged / Myocardial Contraction / Myocardial Infarction / Myocardial Perfusion Imaging / Observer Variation / Predictive Value of Tests / Reproducibility of Results / Tomography, Emission-Computed, Single-Photon / Ventricular Dysfunction, Left / Ventricular Function, Left
(出版サイトへのリンク): ● Publication site (DOI): 10.1253/circj.CJ-10-0551
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21099120; ● Search Scopus @ Elsevier (PMID): 21099120; ● Search Scopus @ Elsevier (DOI): 10.1253/circj.CJ-10-0551

(DOI: 10.1253/circj.CJ-10-0551, PubMed: 21099120) 門田宗之, 竹谷善雄, 若槻哲三, 山口浩司, 楠瀬賢也, 仁木敏之, 坂東左知子, 久岡白陽花, 上田由佳, 冨田紀子, 竹内秀和, 岩瀬俊, 山田博胤, 添木武, 赤池雅史, 佐田政隆, 長井幸二郎, 土井俊夫 :
繰り返す心不全と維持透析導入から離脱しえた腎動脈狭窄症の一例,
四国医学雑誌, Vol.66, No.5, 6, 175-180, 2010年.

(徳島大学機関リポジトリ): ● Metadata: 110339

(徳島大学機関リポジトリ: 110339) Shusuke Yagi, Masashi Akaike, Takashi Iwase, Kenya Kusunose, Toshiyuki Niki, Koji Yamaguchi, Kunihiko Koshiba, Sumiko Yoshida, Yuka Sumitomo-Ueda, Ken-ichi Aihara, Yoichiro Hirata, Munkhbaatar Dagvasumberel, Yoshio Taketani, Noriko Tomita, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Toshio Matsumoto and Masataka Sata :
Bosentan ameliorated exercise-induced pulmonary arterial hypertension complicated with systemic sclerosis.,
Internal Medicine, Vol.49, No.21, 2309-2312, 2010.

(要約): Pulmonary arterial hypertension (PAH) is a frequent complication in patients with systemic sclerosis. Bosentan is used in patients with symptomatic PAH; however, it has not been established whether or not bosentan ameliorates the progression of PAH in patients with no PAH-related symptoms. We present a case of systemic sclerosis with no PAH-related symptoms in which bosentan ameliorated exercise-induced PAH evaluated by 6-minute walk stress echocardiography, brachial flow-mediated dilation, and skin temperature of hands and feet. The results suggest that administration of bosentan in patients with early-stage PAH ameliorates pulmonary arterial vasodilatation through improvement of endothelial function.
(キーワード): Exercise / Exercise Test / Female / Humans / Hypertension, Pulmonary / Middle Aged / Scleroderma, Systemic / Sulfonamides
(出版サイトへのリンク): ● Publication site (DOI): 10.2169/internalmedicine.49.3812
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21048365; ● CiNii @ 国立情報学研究所 (CRID): 1390282679847104768; ● Search Scopus @ Elsevier (PMID): 21048365; ● Search Scopus @ Elsevier (DOI): 10.2169/internalmedicine.49.3812

(DOI: 10.2169/internalmedicine.49.3812, PubMed: 21048365, CiNii: 1390282679847104768) Kenya Kusunose, Hirotsugu Yamada, Takashi Iwase, Susumu Nishio, Noriko Tomita, Toshiyuki Niki, Koji Yamaguchi, Kunihiko Koshiba, Yoshio Taketani, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike, Shoichiro Takao, Masafumi Harada, Noriko Kagawa, Eiji Kudo and Masataka Sata :
Images in cardiovascular medicine. Cardiac magnetic resonance imaging and 2-dimensional speckle tracking echocardiography in secondary cardiac amyloidosis.,
Circulation Journal, Vol.74, No.7, 1494-1496, 2010.

(キーワード): Aged / Amyloidosis / Echocardiography / Heart Diseases / Humans / 磁気共鳴映像法 (magnetic resonance imaging) / Male / Mitral Valve / Regional Blood Flow
(出版サイトへのリンク): ● Publication site (DOI): 10.1253/circj.CJ-10-0141
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20501956; ● Search Scopus @ Elsevier (PMID): 20501956; ● Search Scopus @ Elsevier (DOI): 10.1253/circj.CJ-10-0141

(DOI: 10.1253/circj.CJ-10-0141, PubMed: 20501956) Shusuke Yagi, Masashi Akaike, Mitsunori Fujimura, Takehiko Kimura, Takeshi Nishiuchi, Takashi Iwase, Ken-ichi Aihara, Sumiko Yoshida, Yuka Sumitomo-Ueda, Kenya Kusunose, Toshiyuki Niki, Koji Yamaguchi, Kunihiko Koshiba, Yoichiro Hirata, Munkhbaatar Dagvasumberel, Yoshio Taketani, Noriko Tomita, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Toshio Matsumoto and Masataka Sata :
Congenital ventricular aneurysm as an unexpected complication of monomorphic premature ventricular contractions.,
Internal Medicine, Vol.49, No.10, 907-912, 2010.

(要約): Congenital ventricular diverticulum (CVD) in adults is a rare cardiac malformation, which includes fibrous type congenital ventricular aneurysm (CVA). CVA is often clinically asymptomatic and shows no abnormality in the electrocardiogram or chest X-ray. However, some cases of sudden death resulting from ventricular tachycardia, cardiac embolism or ventricular rupture have been reported. Therefore, physicians should perform further cardiac imaging studies to detect a CVA if ventricular arrhythmia originating from the left ventricle is observed. Here, we report two successfully followed cases of CVA which were diagnosed from premature ventricular contractions.
(キーワード): congenital ventricular aneurysm / congenital ventricular diverticulum / ventricular arrythmia
(出版サイトへのリンク): ● Publication site (DOI): 10.2169/internalmedicine.49.3008
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20467175; ● CiNii @ 国立情報学研究所 (CRID): 1390001204871212928; ● Search Scopus @ Elsevier (PMID): 20467175; ● Search Scopus @ Elsevier (DOI): 10.2169/internalmedicine.49.3008

(DOI: 10.2169/internalmedicine.49.3008, PubMed: 20467175, CiNii: 1390001204871212928) Shusuke Yagi, Masashi Akaike, Ken-ichi Aihara, Takashi Iwase, Kazue Ishikawa, Sumiko Yoshida, Yuka Sumitomo-Ueda, Kenya Kusunose, Toshiyuki Niki, Koji Yamaguchi, Kunihiko Koshiba, Yoichiro Hirata, Munkhbaatar Dagvasumberel, Yoshio Taketani, Noriko Tomita, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Toshio Matsumoto and Masataka Sata :
Ezetimibe ameliorates metabolic disorders and microalbuminuria in patients with hypercholesterolemia.,
Journal of Atherosclerosis and Thrombosis, Vol.17, No.2, 173-180, 2010.

(要約): AIM: Ezetimibe, an inhibitor of Niemann-Pick C1-like 1 protein, has been shown to reduce the intestinal absorption of cholesterol. We investigated whether it also has beneficial effects on metabolic disorder and/or renal insufficiency in patients with hypercholesterolemia. METHODS: Ezetimibe was administered to 38 Japanese patients with hypercholesterolemia to obtain appropriate low-density lipoprotein cholesterol (LDL-chol) levels. Age- and sex-matched patients with hypercholesterolemia (n=38) were the controls. We evaluated the effects of ezetimibe before and 4 to 8 weeks after ezetimibe treatment. RESULTS: Ezetimibe significantly decreased LDL-chol levels and metabolic syndrome-related factors, including body weight, waist circumference, blood pressure; homeostasis model assessment insulin resistance (HOMA-IR), and urinary albumin excretion, were significantly reduced. In addition, it decreased the level of high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor (TNF)-alpha, the urinary excretion of 8-hydroxy-2'-deoxyguanosine, a parameter of oxidative stress, and increased the urinary excretion of nitrate and nitrite (NOx). In the controls we observed no such changes. Excepting the decrease in the serum TNF-alpha level, the effects of ezetimibe were not correlated with decreased LDL-chol levels. CONCLUSION: Ezetimibe ameliorated the status of metabolic syndrome and microalbuminuria, reduced inflammation and oxidative stress, and increased nitric oxide bioavailability in a LDL-chol reduction-dependent and -independent manner.
(キーワード): Aged / Albuminuria / Anticholesteremic Agents / Azetidines / C-Reactive Protein / Case-Control Studies / Cholesterol, LDL / Deoxyguanosine / Female / Humans / Hypercholesterolemia / Male / Metabolic Diseases / Metabolic Syndrome X / Middle Aged / Nitrates / Nitrites / Oxidative Stress / Tumor Necrosis Factor-alpha
(出版サイトへのリンク): ● Publication site (DOI): 10.5551/jat.2378
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20150722; ● Search Scopus @ Elsevier (PMID): 20150722; ● Search Scopus @ Elsevier (DOI): 10.5551/jat.2378

(DOI: 10.5551/jat.2378, PubMed: 20150722) Takashi Iwase, Shoichiro Takao, Masashi Akaike, K Adachi, Y Sumitomo-Ueda, Shusuke Yagi, T Niki, Kenya Kusunose, N Tomita, Y Hirata, Koji Yamaguchi, Kunihiko Koshiba, Yoshio Taketani, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, KI Aihara, Masafumi Harada, H Nishitani and Masataka Sata :
Diagnostic utility of cardiac magnetic resonance for detection of cardiac involvement in female carriers of Duchenne muscular dystrophy.,
Heart Asia, Vol.2, 52-55, 2010.

(出版サイトへのリンク): ● Publication site (DOI): 10.1136/ha.2010.002006
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27325943; ● Search Scopus @ Elsevier (PMID): 27325943; ● Search Scopus @ Elsevier (DOI): 10.1136/ha.2010.002006

(DOI: 10.1136/ha.2010.002006, PubMed: 27325943) Kenya Kusunose, Hirotsugu Yamada, S Nishio, N Tomita, T Niki, K Yamaguchi, Kunihiko Koshiba, Shusuke Yagi, Y Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Clinical Utility of Single Beat E/e' Obtained by Simultaneous Recording of Flow and Tissue Doppler Velocities in Atrial Fibrillation with Preserved Systolic Function.,
JACC. Cardiovascular Imaging, Vol.2, No.10, 1147-1156, 2009.

(要約): We evaluated the usefulness of the ratio of the early diastolic transmitral flow velocity (E) to the mitral annular velocity (e') calculated from simultaneously recorded E and e' in atrial fibrillation (AF). The ratio of the E to the e' (E/e') has been reported as a useful index even in AF patients. However, E and e' were measured during different beats in the previous studies. Fifty-six AF patients with preserved systolic function (mean age 66 +/- 11 years) underwent routine echocardiographic study. The E/e' was calculated from the E and e' simultaneously recorded by the dual Doppler echocardiography. A single-beat E/e' was calculated from simultaneously recorded E and e' when the preceding RR interval/pre-preceding RR interval = 1. Brain natriuretic peptide (BNP) levels were also examined. Twenty-one patients underwent simultaneous pulmonary artery catheterization. The single-beat lateral E/e' correlated with pulmonary capillary wedge pressure (PCWP) (r = 0.74, p < 0.001). The single-beat lateral E/e' of >or=11 could predict elevated PCWP (>or=15 mm Hg) with a sensitivity of 90% and a specificity of 90%. The single-beat lateral E/e' also correlated well with the log BNP concentration. The single-beat lateral E/e' of >or=9.2 predicted a plasma BNP level of >or=200 pg/ml with 88% sensitivity and 84% specificity. The single-beat lateral E/e' correlated with plasma BNP level and PCWP in AF patients with preserved systolic function. In addition, the single-beat lateral E/e' (>or=11) was a good predictor of elevated PCWP (>or=15 mm Hg). Dual Doppler echocardiography offers an advantage of providing the single-beat lateral E/e' correctly even in AF patients, for the evaluation of left ventricular diastolic function.
(キーワード): Adult / Aged / Aged, 80 and over / Atrial Fibrillation / Biological Markers / Catheterization, Swan-Ganz / Coronary Circulation / Diastole / Echocardiography, Doppler, Color / Echocardiography, Doppler, Pulsed / Female / Heart Rate / Humans / Linear Models / Male / Middle Aged / Mitral Valve / Natriuretic Peptide, Brain / Predictive Value of Tests / Pulmonary Wedge Pressure / Sensitivity and Specificity / Systole / Ventricular Function, Left
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jcmg.2009.05.013
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19833302; ● Search Scopus @ Elsevier (PMID): 19833302; ● Search Scopus @ Elsevier (DOI): 10.1016/j.jcmg.2009.05.013

(DOI: 10.1016/j.jcmg.2009.05.013, PubMed: 19833302) Kenya Kusunose, Hirotsugu Yamada, Takashi Todoroki, Susumu Nishio, Toshiyuki Niki, Koji Yamaguchi, Kunihiko Koshiba, Shusuke Yagi, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike, Tetsuya Kitagawa and Masataka Sata :
Platypnea-orthodeoxia syndrome associated with patent foramen ovale and aortic ectasia.,
Echocardiography, Vol.26, No.1, 114-117, 2008.

(要約): A 59-year-old man was admitted for dyspnea on exertion and edema. The patient did not have any pulmonary diseases that could cause dyspnea. Transesophageal echocardiography on the tilting bed with contrast infusion revealed a right-to-left shunt through the patent foramen ovale. Therefore, he was diagosed as platypnea-orthodeoxia syndrome due to the patent foramen ovale. Surgical closure was done and all of his symptoms had improved.
(キーワード): Aortic Diseases / Dyspnea / 経食道心エコー (transesophageal echocardiography) / Edema, Cardiac / Foramen Ovale, Patent / Humans / Male / Middle Aged / 症候群 (syndrome) / Treatment Outcome
(出版サイトへのリンク): ● Publication site (DOI): 10.1111/j.1540-8175.2008.00780.x
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19017323; ● Search Scopus @ Elsevier (PMID): 19017323; ● Search Scopus @ Elsevier (DOI): 10.1111/j.1540-8175.2008.00780.x

(DOI: 10.1111/j.1540-8175.2008.00780.x, PubMed: 19017323) K Yamaguchi, Tetsuzo Wakatsuki, Kenya Kusunose, T Niki, K Koshiba, Hirotsugu Yamada, Takeshi Soeki and Masashi Akaike :
A case of neurogenic myocardial stunning presenting transient left ventricular mid-portion ballooning simulating atypical takotsubo cardiomyopathy.,
Journal of Cardiology, Vol.52, No.1, 53-58, 2008.

(要約): A 57-year-old female patient, who was initially suspected to have subarachnoid hemorrhage, was admitted to our hospital. She experienced severe dyspnea and chest pain owing to pneumonia on the fourth admission day. Electrocardiography showed ST-segment elevation in leads V(2) through V(5), and echocardiography revealed hypokinetic left ventricular wall motion. No stenosis was found in the coronary arteries by urgent coronary angiography. However, left ventriculography revealed that the basal and apical areas were hyperkinetic and the mid portion was akinetic. After a month, left ventricular wall motion was improved and coronary artery spasm provocation tests were negative. Although the clinical course of this patient was similar to that of neurogenic myocardial stunning, the shape of her left ventricle was not typical.
(キーワード): Coronary Angiography / Diagnosis, Differential / Echocardiography / Electrocardiography / Female / Humans / Middle Aged / Myocardial Stunning / Takotsubo Cardiomyopathy / Ventricular Dysfunction, Left
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jjcc.2008.03.004
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18639778; ● Search Scopus @ Elsevier (PMID): 18639778; ● Search Scopus @ Elsevier (DOI): 10.1016/j.jjcc.2008.03.004

(DOI: 10.1016/j.jjcc.2008.03.004, PubMed: 18639778) 河野智仁, 福田大和, 渡部智紀, 山口浩司, 小柴邦彦, 山田博胤, 添木武, 若槻哲三, 伊東進, 野村昌弘 :
本態性高血圧症におけるアゼルニジピンの自律神経活動に及ぼす影響についての検討,
Therapeutic Research, Vol.27, No.2, 249-253, 2006年.

(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-34249101008

(Elsevier: Scopus) 小柴邦彦, 河野智仁, 福田大和, 渡部智紀, 山口浩司, 山田博胤, 添木武, 若槻哲三, 伊東進, 野村昌弘 :
心肥大を合併する本態性高血圧患者におけるアゼルニジピンによる抗動脈効果作用および心肥大抑制作用の検討,
Therapeutic Research, Vol.27, 115-120, 2006年.

(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-77954413525

(Elsevier: Scopus) Tomonori Watanabe, Hiroyuki Fujinaga, Yasumasa Ikeda, Teruo HIgashi, Masaru Murakami, Keiji Kawahara, Ikuo Hayashi, Toshiharu Niki, Toshio Shigekiyo and Tetsuzo Wakatsuki :
Acute myocardial infarction in a patient with essential thrombocythemia who underwent successful stenting. A case report,
Angiology, Vol.56, No.6, 771-774, 2005.

(要約): Essential thrombocythemia (ET) can cause systemic vascular thrombosis, but involvement of coronary arteries in the setting of ET is rare. This report describes a case of acute myocardial infarction (MI) in a patient with ET. A 67-year-old man with ET complained of severe acute chest pain. Emergent coronary angiography revealed subtotal thrombotic occlusion of the left main trunk (LMT) coronary artery. Coronary angioplasty and stenting were performed successfully. Coronary angiography 4 weeks later revealed no significant restenosis. The patient has done well after primary coronary stenting with the use of only an antiplatelet agent to treat the thrombocythemia.
(キーワード): Aged / Angioplasty, Balloon, Coronary / Humans / Male / Myocardial Infarction / Platelet Aggregation Inhibitors / Stents / Thrombocythemia, Essential
(出版サイトへのリンク): ● Publication site (DOI): 10.1177/000331970505600616
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 16327955; ● Search Scopus @ Elsevier (PMID): 16327955; ● Search Scopus @ Elsevier (DOI): 10.1177/000331970505600616

(DOI: 10.1177/000331970505600616, PubMed: 16327955) 山口浩司, 野村昌弘, 小柴邦彦, 河野智仁, 木村恵理子, 渡部智紀, 山田博胤, 若槻哲三, 田畑智継, 西角彰良, 伊東進 :
最大酸素摂取量と血中ホモシステインとの関連性:トータル·ヘルス·プロモーション·プラン検診による検討,
心臓, Vol.37, 37-38, 2005年.

(要約): トータル·ヘルス·プロモーション·プランによる健康づくりにより，ホモシステイン濃度の低下がみられ，動脈硬化を減少させると考えられた．

Koichi Sakabe, Nobuo Fukuda, Teru Nada, Hisanori Shinohara, Yoshiyuki Tamura, Tetsuzo Wakatsuki, Akiyoshi Nishikado and Takashi Oki :
Atrial electrophysiologic abnormalities in patients with Wolff-Parkinson-White syndrome but without paroxysmal atrial fibrillation,
Clinical Cardiology, Vol.27, No.7, 396-400, 2004.

(要約): Paroxysmal atrial fibrillation (PAF) frequently occurs in patients with Wolff-Parkinson-White (WPW) syndrome. The purpose of this study was to analyze the atrial electrophysiologic abnormalities and vulnerability to develop atrial fibrillation (AF) in patients with WPW syndrome but with no previous history of PAF. We investigated atrial electrophysiologic abnormalities and vulnerability to AF in patients with WPW syndrome but without PAF. An electrophysiologic study was performed in 28 patients with WPW syndrome, 23 with atrioventricular nodal reentrant tachycardia (AVNRT) and 25 with other arrhythmias (control), all of whom had no history of PAF. The following atrial excitability parameters were assessed: effective refractory period (ERP), spontaneous or paced (A1) and extrastimulated (A2) atrial electrogram widths, percent maximum atrial fragmentation (%MAF; A2/A1 x 100), wavelength index (WLI; ERP/A2), and inducibility of AF. The ERP tended to be shorter in patients with WPW syndrome and in those with AVNRT than in the control group. The %MAF increased (154 +/- 33 vs. 137 +/- 23%, p < 0.05) and WLI decreased (2.7 +/- 0.8 vs. 3.4 +/- 1.0, p < 0.05) significantly in patients with WPW syndrome compared with the control group; however, these parameters in patients with AVNRT showed intermediate values. Atrial fibrillation was more inducible in patients with WPW syndrome (4/28 [14.3%]) than in those with AVNRT (4.3% [1/23]) and the control group (0/25 [0%]). With respect to patients with WPW syndrome and with and without inducible AF, the %MAF increased (195 +/- 23 vs. 148 +/- 30%, p < 0.01) and the WLI decreased (2.2 +/- 0.3 vs. 2.9 +/- 0.9, p < 0.05) in subjects with inducible AF. Atrial electrophysiologic abnormalities, especially atrial conduction delays, are more prominent in patients with WPW syndrome, even if they had no previous history of PAF. These abnormalities may play an important role in determining the vulnerability to AF.
(キーワード): Wolff-Parkinson-White syndrome / atrial fibrillation / electrophysiology / atrial vulnerability / atrioventricular nodal reentrant
(出版サイトへのリンク): ● Publication site (DOI): 10.1002/clc.4960270706
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15298039; ● Search Scopus @ Elsevier (PMID): 15298039; ● Search Scopus @ Elsevier (DOI): 10.1002/clc.4960270706

(DOI: 10.1002/clc.4960270706, PubMed: 15298039) Hirotsugu Yamada, Takashi Oki, Takashi Yamamoto, Hideji Tanaka, Tomotsugu Tabata, Tetsuzo Wakatsuki, Masahiro Nomura, Susumu Ito and James D. Thomas :
Potential application of tissue Doppler imaging to assess regional left ventricular diastolic function in patients with hypertrophic cardiomyopathy: Comparison with 123I-β-methyl iodophenyl pentadecanoic acid myocardial scintigraphy.,
Clinical Cardiology, Vol.27, No.1, 33-39, 2004.

(要約): Tissue Doppler imaging (TDI) has been utilized to evaluate left ventricular myocardial dysfunction in patients with hypertrophic cardiomyopathy (HCM); however, no clear explanation for the abnormality of TDI variables has been forthcoming. Peak negative myocardial velocity gradient (MVG) derived from TDI may correlate with a disorder of fatty acid metabolism in patients with HCM. Tissue Doppler imaging and 123I-beta-methyl iodophenyl pentadecanoic acid (123I-BMIPP) myocardial scintigraphy were performed in 15 patients with asymmetric septal hypertrophy (mean age 47 +/- 18 years) and in 12 healthy controls (mean age 43 +/- 10 years). In early 123I-BMIPP images, accumulation defects were observed in the ventricular septum in 12 patients and in the posterior wall in 8 patients with HCM. Peak negative MVG in the ventricular septum (1.1 +/- 0.5 vs. 2.8 +/- 0.5, p < 0.0001) and posterior wall (5.2 +/- 1.4 vs. 6.7 +/- 0.8, p < 0.01 ) was significantly lower in the HCM group than in the controls; also, these parameters were significantly lower in patients with than in those without a defect in the region in question. The peak negative MVG in the ventricular septum and posterior wall correlated inversely with the washout rate in all subjects. Peak negative MVG according to TDI is related to disorder of fatty acid metabolism in the regional left ventricular myocardium of patients with HCM.
(キーワード): Cardiomyopathy, Hypertrophic / Case-Control Studies / Diastole / Echocardiography, Doppler, Pulsed / Fatty Acids / Female / Heart Septum / Humans / Iodine Radioisotopes / Iodobenzenes / Male / Middle Aged / Myocardium / Ventricular Dysfunction, Left
(出版サイトへのリンク): ● Publication site (DOI): 10.1002/clc.4960270109
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 14743854; ● Search Scopus @ Elsevier (PMID): 14743854; ● Search Scopus @ Elsevier (DOI): 10.1002/clc.4960270109

(DOI: 10.1002/clc.4960270109, PubMed: 14743854) Koichi Sakabe, Nobuo Fukuda, Takeshi Soeki, H Shinohara, Y Tamura, Tetsuzo Wakatsuki, Akiyoshi Nishikado and Takashi Oki :
Relation of age and sex to atrial electrophysiological properties in patients with no history of atrial fibrillation.,
Pacing and Clinical Electrophysiology, Vol.26, No.5, 1238-1244, 2003.

(要約): Although atrial fibrillation is a common arrhythmia, especially in elderly men, little is known about age related changes in atrial electrophysiological properties or gender differences. The aim of this study was to analyze the effects of aging on vulnerability to atrial fibrillation and assessed gender differences in those age related changes. An electrophysiological study was performed on 73 patients with no history of atrial fibrillation, structural heart disease, or conditions with potential effects on cardiac hemodynamic or electrophysiological function, including 25 women (mean age 49 +/- 18 years; range 12-84 years). The following atrial excitability parameters were assessed: spontaneous or paced (A1) and extrastimulated (A2) atrial electrogram widths, percent maximum atrial fragmentation (A2/A1 x 100), effective refractory period, wavelength index (effective refractory period/A2), and inducibility of atrial fibrillation. There were no significant differences in percent maximum atrial fragmentation (143 +/- 28 vs 142 +/- 35%), effective refractory period (241 +/- 39 vs 238 +/- 50 ms), wavelength index (2.9 +/- 0.8 vs 3.1 +/- 0.9), induction of atrial fibrillation (10 [21%] vs 7 [28%]), or age (50 +/- 17 vs 49 +/- 20 years) between men and women. Age was not statistically different between those patients with and without induction of atrial fibrillation in men (48 +/- 14 vs 50 +/- 18 years) and women (48 +/- 18 vs 49 +/- 21 years). Percent maximum atrial fragmentation and effective refractory period were directly correlated with age in men (r = 0.35, P = 0.01; r = 0.46, P < 0.001, respectively) and women (r = 0.42, P = 0.04; r = 0.45, P = 0.02, respectively), though wavelength index did not correlate with age in men (r = -0.04) or women (r = -0.04) with no history of atrial fibrillation. Considering these findings, the authors conclude that the mechanism triggering atrial fibrillation may be different between older and younger patients with atrial fibrillation, because younger patients who have no marked substrate for atrial fibrillation may need many trigger beats to induce atrial fibrillation.
(キーワード): Adolescent / Adult / Age Factors / Aged / Aged, 80 and over / Aging / Atrial Fibrillation / Chi-Square Distribution / Child / Electrophysiologic Techniques, Cardiac / Female / Heart Atria / Humans / Linear Models / Male / Middle Aged / Sex Factors / Wolff-Parkinson-White Syndrome
(出版サイトへのリンク): ● Publication site (DOI): 10.1046/j.1460-9592.2003.t01-1-00174.x
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12765452; ● Search Scopus @ Elsevier (PMID): 12765452; ● Search Scopus @ Elsevier (DOI): 10.1046/j.1460-9592.2003.t01-1-00174.x

(DOI: 10.1046/j.1460-9592.2003.t01-1-00174.x, PubMed: 12765452) Kouichi Sakabe, Nobuo Fukuda, Teru Nada, Hisanori Shinohara, Yoshiyuki Tamura, Tetsuzo Wakatsuki, Akiyoshi Nishikado and Takashi Oki :
Age-related changes in the electrophysiologic properties of the atrium in patients with no history of atrial fibrillation,
Japanese Heart Journal, Vol.44, No.3, 385-393, 2003.

(要約): Although atrial fibrillation is a common arrhythmia, especially in the elderly, little is known about age-related changes in the electrophysiologic properties of the atrium. The aim of this study was to analyze the effect of aging on atrial vulnerability to atrial fibrillation. An electrophysiologic study was performed in 45 patients with no history of atrial fibrillation, Wolff-Parkinson-White syndrome, structural heart disease, or conditions with potential effects on cardiac hemodynamic or electrophysiologic function (15 females; mean age, 52 +/- 18 years; range, 14 to 84 years). The following atrial excitability parameters were assessed: spontaneous or paced (A1) and extrastimulated (A2) atrial electrogram widths, percent maximum atrial fragmentation (A2/A1 x 100), effective refractory period, wavelength index (ERP/A2), and inducibility of atrial fibrillation. Atrial fibrillation was induced in 9 patients. Percent maximum atrial fragmentation was greater (176 +/- 36 vs 137 +/- 26%, P < 0.001) and wavelength index was shorter (2.4 +/- 0.4 vs 3.2 +/- 0.9, P < 0.01) in the patients with than without inducible atrial fibrillation. However, age was similar in patients with and without inducible atrial fibrillation (47 +/- 11 vs 53 +/- 19 years, P = 0.36). Percent maximum atrial fragmentation and effective refractory period directly correlated with age (r = 0.32, P < 0.05 and r = 0.45, P < 0.001, respectively). On the other hand, wavelength index (3.1 +/- 0.9) did not correlate with age (r = -0.05, P = 0.77). This study suggests that the mechanism triggering atrial fibrillation may be very well different between older and younger patients with atrial fibrillation, because younger patients have no marked substrate for atrial fibrillation.
(キーワード): Aging / Electrophysiology / Wavelength
(出版サイトへのリンク): ● Publication site (DOI): 10.1536/jhj.44.385
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12825806; ● CiNii @ 国立情報学研究所 (CRID): 1390282680014529920; ● Search Scopus @ Elsevier (PMID): 12825806; ● Search Scopus @ Elsevier (DOI): 10.1536/jhj.44.385

(DOI: 10.1536/jhj.44.385, PubMed: 12825806, CiNii: 1390282680014529920) Takashi Yamamoto, Takashi Oki, Hirotsugu Yamada, Hideji Tanaka, Tomotsugu Tabata, T Ishimoto, Tetsuzo Wakatsuki and Susumu Ito :
Prognostic value of the atrial systolic mitral annular motion velocity in patients with left ventricular systolic dysfunction.,
Journal of the American Society of Echocardiography, Vol.16, No.4, 333-339, 2003.

(要約): Transmitral flow velocity variables are powerful predictors of poor prognosis in patients with left ventricular (LV) systolic dysfunction. However, these variables may not accurately reflect the severity of pulmonary congestion. This study was designed to determine whether the peak atrial systolic mitral annular motion velocity (MA-Aw) measured by pulsed Doppler tissue imaging can predict cardiac death or hospitalization for worsening heart failure in patients with LV systolic dysfunction. MA-Aw was recorded in 96 patients with LV systolic dysfunction who were followed up for 29 +/- 10 months. All patients underwent Doppler echocardiography on entry into the study, and cardiac catheterization was performed in 45 patients. Patients were divided into 3 groups on the basis of the ratio of early (E) to late (A) diastolic filling (E/A) of the transmitral flow velocity: group 1 (n=31; E/A < 1); group 2 (n=37; 1 < or = E/A < 2); and group 3 (n=28; E/A > or = 2). During follow-up, 36 patients (38%) died of cardiac causes and 34 (35%) were hospitalized for worsening heart failure. There were 2 cardiac deaths (6%) in group 1, 14 (39%) in group 2, and 20 (56%) in group 3. The MA-Aw correlated closely with the mean pulmonary capillary wedge pressure. Univariate Cox model analysis showed that MA-Aw < or = 5 cm/s was the most powerful predictor of cardiac death or hospitalization for worsening heart failure compared with clinical, hemodynamic, and the other echocardiographic variables. Furthermore, MA-Aw < or = 5 cm/s was clearly discernible as a good predictor of cardiac mortality on multivariate Cox model and as assessed by Kaplan-Meier method. The MA-Aw obtained by pulsed Doppler tissue imaging is a sensitive index of pulmonary congestion in patients with LV systolic dysfunction. It is a simple and noninvasive outcome measure and can be used to monitor treatment.
(キーワード): PULMONARY VENOUS FLOW / CONGESTIVE-HEART-FAILURE / IDIOPATHIC DILATED CARDIOMYOPATHY / PULSED DOPPLER-ECHOCARDIOGRAPHY / END-DIASTOLIC PRESSURE / FILLING PRESSURES / CARDIAC DISEASE / REGURGITATION / DIFFERENCE / SECONDARY
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0894-7317(02)74537-9
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12712015; ● Search Scopus @ Elsevier (PMID): 12712015; ● Search Scopus @ Elsevier (DOI): 10.1016/S0894-7317(02)74537-9

(DOI: 10.1016/S0894-7317(02)74537-9, PubMed: 12712015) Tetsuzo Wakatsuki :
Relation of age and sex to atrial electrophysiological properties in patients with no history of atrial fibrillation,
PACE, Vol.26, 1-7, 2003. Takuzi Tada, Takashi Oki, Miho Abe, Masako Matsuoka, Tomotsugu Tabata, Hirotsugu Yamada, T Yamamoto, Tetsuzo Wakatsuki and Susumu Ito :
The role of short- and long-axis function in determining late diastolic left ventricular filling in patients with hypertension: Assessment by pulsed Doppler tissue imaging.,
Journal of the American Society of Echocardiography, Vol.15, No.10 Supplement, 1211-1217, 2002.

(要約): Left ventricular (LV) wall motion velocity during atrial systole is mediated by both transmitral flow and LV myocardial compliance at end-diastole. LV wall distensibility along the long- and short-axis during atrial systole and late diastolic LV filling may vary according to the remodeling of LV morphology. We measured LV wall motion velocities along the long and short axes using pulsed Doppler tissue imaging in 127 patients with hypertension to evaluate the relationship between the hemodynamic changes and LV morphology and to determine the role of both long- and short-axis function in late diastolic LV filling. Participants were classified into 3 groups according to LV dimension and end-diastolic wall thickness determined by M-mode echocardiography: group A (n = 62) without LV dilation or hypertrophy, group B (n = 55) with LV hypertrophy, and group C (n = 10) with LV dilation and systolic dysfunction. The time constant of the LV pressure decay during isovolumic diastole and the LV end-diastolic pressure were longest and greatest, respectively, in group C, compared with groups B and A. There were no significant differences in active left atrial emptying volume during atrial contraction determined by computerized echocardiographic 3-dimensional reconstruction among patient and control groups. The peak atrial systolic motion velocity of the LV posterior wall along the long axis was significantly lower in groups B and C, particularly in the latter group, than in group A. The peak atrial systolic motion velocity of the LV posterior wall along the short axis was greatest in group B and was lowest in group C compared with the other groups, respectively. The peak atrial systolic motion velocity of the LV posterior wall was greater along the long axis than the short axis in group A, but was less than the short axis in group B. In conclusion, the long- and short-axis function of the LV wall during atrial systole varies in patients with hypertension according to the severity of hemodynamic and morphologic abnormalities. The degree of LV wall expansion along the short axis is an important factor resulting from the atrial kick, and a determinant of its effectiveness.
(キーワード): TRANSMITRAL FLOW VELOCITY / WALL-MOTION VELOCITIES / CONSTRICTIVE PERICARDITIS / HEALTHY-SUBJECTS / HEART-FAILURE / CARDIOMYOPATHY / INFLOW / ECHOCARDIOGRAPHY / ABNORMALITIES / HYPERTROPHY
(出版サイトへのリンク): ● Publication site (DOI): 10.1067/mje.2002.124007
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12411907; ● Search Scopus @ Elsevier (PMID): 12411907; ● Search Scopus @ Elsevier (DOI): 10.1067/mje.2002.124007

(DOI: 10.1067/mje.2002.124007, PubMed: 12411907) Takashi Harada, Masahito Tomotake, Akira Ohkubo, Akiyoshi Nishikado, Takashi Yamamoto, Tetsuzo Wakatsuki and Tetsuro Ohmori :
Radiofrequency catheter ablation enabled antipsychotic treatment in a schizophrenic patient with idiopathic ventricular tachycardia,
General Hospital Psychiatry, Vol.24, No.4, 277-278, 2002.

(キーワード): INTERVAL / DRUGS
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0163-8343(02)00187-1
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12100841; ● Search Scopus @ Elsevier (PMID): 12100841; ● Search Scopus @ Elsevier (DOI): 10.1016/S0163-8343(02)00187-1

(DOI: 10.1016/S0163-8343(02)00187-1, PubMed: 12100841) Masako Matsuoka, Takashi Oki, Yuichiro Mishiro, Hirotsugu Yamada, Tomotsugu Tabata, Tetsuzo Wakatsuki and Susumu Ito :
Early systolic mitral annular motion velocities responses to dobutamine infusion predict myocardial viability in patients with previous myocardial infarction.,
American Heart Journal, Vol.143, No.3, 552-558, 2002.

(要約): This study was undertaken for the determination of the correlation between myocardial viability and regional systolic mitral annular motion velocity (MAV) response to dobutamine stress in patients with previous myocardial infarction (MI) with pulsed tissue Doppler scan imaging. The study included 45 patients (mean age, 65 +/- 12 years) with previous MI with 1 major coronary lesion and 30 healthy individuals (mean age, 61 +/- 14 years). 99mTc-methoxyisobutylisonitrile scintigraphy was performed to divide the patients into 2 groups: the viability (+) group (n = 25) and the viability (-) group (n = 20). Dobutamine was infused (at 2, 5, 10, and 20 microg/kg/min), and the peak first and second systolic MAVs (Sw1 and Sw2, respectively) were measured at the level of the mitral annulus corresponding to the infarct regions in the MI group and to the 6 mitral annular sites in the control group. In addition, the left ventricular wall motion score index (WMSI) was determined with 2-dimensional echocardiography. At baseline, the WMSI was significantly greater and the mean Sw1 and Sw2 were significantly lower in both the viability (+) and (-) groups than in the control group, but there were no significant differences between the viability (+) and (-) groups. After dobutamine infusion, the WMSI improved only in the viability (+) group. The mean Sw1 and Sw2 increased significantly with 2 microg/kg/min and 5 microg/kg/min of dobutamine, respectively, in the viability (+) group. With an increase in Sw1 of 2.0 cm/s or more with 5 microg/kg/min of dobutamine, viable myocardium was detected, with a sensitivity of 92% and a specificity of 90%. There were no significant increases in Sw1 or Sw2 in the viability (-) group with dobutamine infusion. Viable left ventricular myocardium is identified with peak early systolic MAV during dobutamine infusion.
(キーワード): VENTRICULAR WALL-MOTION / TISSUE DOPPLER-ECHOCARDIOGRAPHY / STRESS ECHOCARDIOGRAPHY / ATRIOVENTRICULAR PLANE / SHORT AXES / DISPLACEMENT / THROMBOLYSIS / REPERFUSION / REINJECTION / TOMOGRAPHY
(出版サイトへのリンク): ● Publication site (DOI): 10.1067/mhj.2002.121266
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11868065; ● Search Scopus @ Elsevier (PMID): 11868065; ● Search Scopus @ Elsevier (DOI): 10.1067/mhj.2002.121266

(DOI: 10.1067/mhj.2002.121266, PubMed: 11868065) Tetsuzo Wakatsuki :
Effects of angiotensin II type 1 receptor antagonist (candesartan) in preventing fatal ventricular arrhythmias in dogs during acute myocardial ischemia and reperfusion,
Journal of Cardiovascular Pharmacology, Vol.38, No.5, 729-736, 2001.

(要約): Fatal arrhythmias may be prevented by long-term oral administration of angiotensin-converting enzyme (ACE) inhibitors or angiotensin II type 1 (AT 1 ) receptor antagonists. However, there have been no studies evaluating the electrophysiologic changes that occur with the acute administration of AT 1 receptor antagonists during acute myocardial ischemia and reperfusion. This study aimed to evaluate the ability of candesartan to prevent fatal arrhythmias during acute myocardial ischemia and reperfusion. The left anterior descending (LAD) coronary artery was ligated for 10 min and then reperfused for 10 min in 45 adult mongrel dogs. Candesartan (1 mg/kg) or saline was administered intravenously 10 min before ligation of the LAD coronary artery (candesartan group [n = 20] and control group [n = 25], respectively). Changes in ventricular effective refractory period (ERP) and intramyocardial conduction time (ICT) in the risk area were compared during LAD occlusion and reperfusion. Ischemia-induced shortening of ERP was inhibited in the candesartan group compared with the control. There was a 4.7 +/- 5.8% increase in ERP in the candesartan group, compared with a 11.5 +/- 6.3% shortening in the control group (p < 0.01). Prolongation of ICT was inhibited in the candesartan group compared with the control group during both ischemia and reperfusion (maximal prolongation of ICT: 0.1 +/- 3.0% vs. 37.7 +/- 9.6%, respectively; p < 0.01). Incidence of ventricular fibrillation was lower in the candesartan group than in the control group (25% [5/20] vs. 72% [18/25], respectively; p < 0.01). Candesartan suppresses changes in ERP and ICT during acute myocardial ischemia and reperfusion, suggesting that candesartan can prevent the development of fatal arrhythmias.
(キーワード): Angiotensin Receptor Antagonists / Animals / Benzimidazoles / Dogs / Heart Conduction System / Hemodynamics / Myocardial Ischemia / Myocardial Reperfusion / Receptor, Angiotensin, Type 1 / Tetrazoles / Time Factors / Ventricular Dysfunction / Ventricular Fibrillation
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11602819; ● Search Scopus @ Elsevier (PMID): 11602819

(PubMed: 11602819) Yukiko Onose, Takashi Oki, Hirotsugu Yamada, Kazuyo Manabe, Yoshimi Kageji, Masako Matsuoka, Takashi Yamamoto, Tomotsugu Tabata, Tetsuzo Wakatsuki and Susumu Ito :
Effect of cilnidipine on left ventricular diastolic function in hypertensive patients as assessed by pulsed Doppler echocardiography and pulsed tissue Doppler imaging.,
Japanese Circulation Journal, Vol.65, No.4, 305-309, 2001.

(要約): The purpose of the present study was to examine the mechanisms of improvement in left ventricular (LV) diastolic function in hypertensive patients treated with cilnidipine, a new and unique calcium antagonist that has both L-type and N-type voltage-dependent calcium channel blocking actions, using pulsed Doppler echocardiography and pulsed tissue Doppler imaging. The study comprised 35 untreated patients with essential hypertension (19 men and 16 women; mean age 65+/-10 years). The peak early diastolic and atrial systolic transmitral flow velocities (E and A, respectively) and their ratio (E/A), and the peak early diastolic and atrial systolic motion velocities (Ew and Aw, respectively) of the LV posterior wall and their ratio (Ew/Aw) were determined in all patients before and after 1, 3 and 6 months on cilnidipine (10 mg/day). One month: Systolic and diastolic blood pressures were significantly decreased. E and E/A were significantly increased, whereas there were no significant changes in Ew and Ew/Aw. Three months: Ew and Ew/Aw were significantly increased compared to those before and 1 month after cilnidipine. Six months: E and E/A were significantly increased compared with before and 3 months after cilnidipine, and Ew and Ew/Aw were significantly increased compared with before cilnidipine. Moreover, the LV mass index was significantly decreased compared to that before cilnidipine. In summary, changes in LV diastolic performance in patients with essential hypertension following cilnidipine treatment were biphasic with an initial increase in early diastolic transmitral flow velocity and a later increase in early diastolic LV wall motion velocity. The initial and later changes can be related to an acute change in afterload and a later improvement in LV relaxation.
(キーワード): Aged / Antihypertensive Agents / Blood Pressure / Calcium Channel Blockers / Calcium Channels, L-Type / Calcium Channels, N-Type / Diastole / Dihydropyridines / Echocardiography, Doppler, Pulsed / Female / Humans / Hypertension / Hypertrophy, Left Ventricular / Male / Middle Aged / Systole / Treatment Outcome / Ventricular Dysfunction, Left / Ventricular Function, Left
(出版サイトへのリンク): ● Publication site (DOI): 10.1253/jcj.65.305
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11316128; ● Summary page in Scopus @ Elsevier: 2-s2.0-0035045829

(DOI: 10.1253/jcj.65.305, PubMed: 11316128, Elsevier: Scopus) 宮島等, 野村昌弘, 澤田幸, 森下智文, 名田智美, 若槻哲三, 西角彰良, 齋藤憲, 大木崇, 伊東進, 原田雅史, 西谷弘, 中屋豊 :
摂食による冠動脈血流速度の変化，胃電図および冠動脈シネMRAを用いた検討,
心臓, Vol.33, No.suppl 2, 7-10, 2001年. Yuichiro Mishiro, Takashi Oki, Hirotsugu Yamada, Yukiko Onose, Masako Matsuoka, Tomotsugu Tabata, Tetsuzo Wakatsuki and Susumu Ito :
Use of angiotensin II stress pulsed tissue Doppler imaging to evaluate regional left ventricular contractility in patients with hypertrophic cardiomyopathy.,
Journal of the American Society of Echocardiography, Vol.13, No.12, 1065-1073, 2000.

(要約): There is controversy concerning whether contract-ility in the nonhypertrophied region of the left ventricular (LV) wall is impaired or normal in patients with hypertrophic cardiomyopathy (HCM). Global LV systolic function decreases with increases in afterload in this disease. This study was performed to identify abnormalities in regional LV contractility along the long and short axes in the setting of HCM with the use of angiotensin II (AT-II) stress pulsed tissue Doppler imaging (PTDI). Angiotensin II was administered intravenously to patients with asymmetric septal hypertrophy (HCM group, n = 21) and age-matched normal volunteers (N group, n = 12). We then measured the percent LV fractional shortening (%FS) and end-systolic circumferential LV wall stress by M-mode echocardiography, LV ejection fraction (LVEF) by 2-dimensional echocardiography, and time-velocity integral (TVI) of LV outflow velocity by pulsed Doppler echocardiography. The peak first and second systolic LV wall motion velocities along the long (L-Sw(1) and L-Sw(2)) and short (S-Sw(1) and S-Sw(2)) axes were measured in the LV posterior wall and ventricular septum with the use of PTDI. The end-systolic circumferential LV wall stress at baseline was significantly lower in the HCM group. The L-Sw(1) and L-Sw(2) for the posterior wall were significantly lower in the HCM group, but the S-Sw(1) and S-Sw(2) for the posterior wall and ventricular septum were similar in the two groups. The %FS, LVEF, TVI, and systolic PTDI variables along both axes for the posterior wall decreased significantly, and end-systolic circumferential LV wall stress increased significantly at AT-II doses of 0.005 or 0.010 microg/kg per minute in the HCM group. No significant changes were found in either group in the systolic PTDI variables (except for L-Sw(1)) for the ventricular septum with AT-II infusion. Contractility along the long and short axes of the nonhypertrophied LV wall is easily impaired with increases in afterload in patients with HCM, resulting in a decrease in global LV systolic function. We found AT-II stress PTDI to be a safe and useful technique for evaluating the regional LV systolic function in this disease.
(キーワード): Analysis of Variance / Angiotensin II / Blood Flow Velocity / Cardiomyopathy, Hypertrophic / Case-Control Studies / Echocardiography, Doppler, Pulsed / Female / Humans / Infusions, Intravenous / Male / Middle Aged / Myocardial Contraction / Vasoconstrictor Agents / Ventricular Dysfunction, Left
(出版サイトへのリンク): ● Publication site (DOI): 10.1067/mje.2000.111010
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11119273; ● Summary page in Scopus @ Elsevier: 2-s2.0-0034524367

(DOI: 10.1067/mje.2000.111010, PubMed: 11119273, Elsevier: Scopus) Jiro Ikata, Tetsuzo Wakatsuki, Yoshifumi Oishi, Takashi Oki and Susumu Ito :
Leukocyte counts and concentrations of soluble adhesion molecules as predictors of coronary atherosclerosis,
Coronary Artery Disease, Vol.11, No.6, 445-449, 2000.

(要約): Authors of recent studies have reported that there is a relationship between level of adhesion molecules and atherosclerosis. In an animal study it was demonstrated that there is an interaction between adhesion molecules and leukocytes in atherosclerotic tissue. To study the relationships between coronary-artery atherosclerosis and both differential blood-leukocyte count and concentrations of soluble adhesion molecules in patients with and without coronary artery disease (CAD). Our subjects were 168 patients who underwent diagnostic coronary angiography. Forty-eight patients had normal coronary angiograms (control group), and 120 patients had significant coronary-artery stenoses (diameter stenosis > 70%) in at least one major coronary-artery branch (CAD group). Total and differential blood-leukocyte counts, and concentrations of soluble intercellular adhesion molecule-1 (sICAM-1) and vascular cell adhesion molecule-1 (sVCAM-1) were assayed prior to angiography. Monocyte counts for patients in the CAD group were significantly greater than those for patients in the control group (366 +/- 99 versus 258 +/- 44/microl, P < 0.0001), as were the sICAM-1 concentrations (272 +/- 52 versus 203 +/- 24 ng/ml, P < 0.0001). The mean concentrations of sVCAM-1 in members of the two groups were the same (671 +/- 138 versus 668 +/- 97 ng/ml, P=0.4). There was a higher incidence of significant coronary-artery stenosis among patients with both a high monocyte count and a high concentration of sICAM-1 (> or = mean + SD) than there was among patients with a low monocyte count and a low concentration of sICAM-1 (> or = mean - SD; 100 versus 25%, P < 0.0001). Higher levels both of monocyte counts and of serum concentrations of ICAM-1 may serve as markers for coronary atherosclerosis.
(キーワード): Biological Markers / Coronary Angiography / Coronary Artery Disease / Female / Humans / Intercellular Adhesion Molecule-1 / Leukocyte Count / Male / Middle Aged / Monocytes / Predictive Value of Tests / Vascular Cell Adhesion Molecule-1
(出版サイトへのリンク): ● Publication site (DOI): 10.1097/00019501-200009000-00001
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10966129; ● Summary page in Scopus @ Elsevier: 2-s2.0-0033847032

(DOI: 10.1097/00019501-200009000-00001, PubMed: 10966129, Elsevier: Scopus) K Miki, T Shinohara, F Ogushi, S Sone, Hirotsugu Yamada, Y Oishi, Tetsuzo Wakatsuki, Susumu Ito, S Yogita and S Tashiro :
Hepatopulmonary syndrome-discussion of cardiopulmonary parameters,
The Journal of Medical Investigation : JMI, Vol.47, No.3-4, 164-169, 2000.

(要約): We report a 70-year-old man with hepatopulmonary syndrome (HPS) in C liver cirrhosis. Hypoxemia worsened markedly, especially on exertion, while the hepatic function was clinically stable. Contrast echocardiography, 99mTc macroaggregated albumin (99mTcMAA) lung scan, and pulmonary angiography were performed. The findings suggested the presence of both intrapulmonary vascular dilatation and substantial right-to-left shunt. The contribution of intrapulmonary vascular abnormalities in patients with severe liver cirrhosis without abnormal chest radiography and spirometry tests when marked hypoxemia is present should be investigated.
(キーワード): Aged / Hepatopulmonary Syndrome / Humans / Male
(徳島大学機関リポジトリ): ● Metadata: 25094
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11019499; ● Search Scopus @ Elsevier (PMID): 11019499

(徳島大学機関リポジトリ: 25094, PubMed: 11019499) Tetsuzo Wakatsuki :
Coronary flow velocity immediately after primary coronary stenting as a predictor of ventricular wall motion recovery in acute myocardial infarction,
Journal of the American College of Cardiology, Vol.35, No.7, 1835-1841, 2000.

(要約): The purpose of this study was to examine the relationship between the pattern of coronary blood flow velocity immediately after successful primary stenting and the recovery of left ventricular (LV) wall motion in patients with acute myocardial infarction (AMI). It is difficult to predict the recovery of LV wall motion immediately after direct angioplasty in AMI. Recent reports indicate that dysfunctional coronary microcirculation is an important determinant of prognosis for AMI patients after successful reperfusion. We measured left anterior descending coronary flow velocity variables using a Doppler guide wire immediately after successful primary stenting in 31 patients with their first anterior AMI. The patients were divided into two groups: those with and those without early systolic reverse flow (ESRF). Changes in LV regional wall motion (RWM) and ejection fraction (EF) at admission and at discharge were compared between the two groups. Coronary flow velocity variables immediately after primary stenting were compared with changes in left ventriculographic indexes. The change in RWM was significantly greater in the non-ESRF group than it was in the ESRF group (0.9 +/- 0.7 vs. -0.1 +/- 0.3 standard deviation/chord, respectively, p < 0.001). The change in EF was also significantly greater in the non-ESRF group than it was in the ESRF group (10 +/- 10 vs. 1 +/- 6%, respectively, p < 0.05). In the non-ESRF group (diastolic to systolic velocity ratio [DSVR] <3.0), the DSVR correlated positively with the change in RWM (r = 0.60, p < 0.005, n = 24) and the change in EF (r = 0.52, p < 0.01). The coronary flow velocity pattern measured immediately after successful primary stenting is predictive of the recovery of regional and global LV function in patients with AMI.
(キーワード): Aged / Blood Flow Velocity / Coronary Circulation / Female / Humans / Male / Middle Aged / Myocardial Infarction / Predictive Value of Tests / Stents / Stroke Volume / Time Factors / Ventricular Function, Left
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0735-1097(00)00632-X
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10841232; ● CiNii @ 国立情報学研究所 (CRID): 1573387449737912704; ● Summary page in Scopus @ Elsevier: 2-s2.0-0034036449

(DOI: 10.1016/S0735-1097(00)00632-X, PubMed: 10841232, CiNii: 1573387449737912704, Elsevier: Scopus) Koichi Sakabe, Tetsuzo Wakatsuki, Hiroyuki Fujinaga, Yoshifumi Oishi, Jiro Ikata, Toshihiro Toyoshima, Norikazu Hiura, Akiyoshi Nishikado, Takashi Oki and Susumu Ito :
Patient with atrioventricular node reentrant tachycardia with eccentric retrograde left-sided activation Treatment with radio-frequency catheter ablation,
Japanese Heart Journal, Vol.41, No.2, 227-234, 2000.

(要約): We describe a patient with supraventricular tachycardia with triple atrioventricular (AV) node pathway physiology. A discontinuous curve was present in the antegrade AV nodal function curves. During right ventricular pacing, the earliest retrograde atrial activation was recorded at the left-sided coronary sinus electrode. The retrograde ventricular-atrial interval was long and had decremental conduction. We induced a slow-slow AV node reentrant tachycardia (AVNRT) with eccentric retrograde left-sided activation. After slow pathway ablation, dual AV nodal pathway physiology was present. AVNRT with eccentric retrograde left-sided activation is relatively rare, and our findings suggest that eccentric retrograde left-sided atrial inputs consist partially of a slow pathway and disappear with slow pathway ablation.
(キーワード): Atrial Function, Left / Cardiac Pacing, Artificial / Catheter Ablation / Female / Fluoroscopy / Humans / Middle Aged / Tachycardia, Atrioventricular Nodal Reentry / Ventricular Function, Right
(出版サイトへのリンク): ● Publication site (DOI): 10.1536/jhj.41.227
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10850538; ● Summary page in Scopus @ Elsevier: 2-s2.0-0034108905

(DOI: 10.1536/jhj.41.227, PubMed: 10850538, Elsevier: Scopus) Takashi Oki, Yuichiro Mishiro, Hirotsugu Yamada, Yukiko Onose, Masako Matsuoka, Tetsuzo Wakatsuki, Tomotsugu Tabata and Susumu Ito :
Detection of left ventricular regional relaxation abnormalities and asynchrony in patients with hypertrophic cardiomyopathy with the use of tissue Doppler imaging.,
American Heart Journal, Vol.139, No.3, 497-502, 2000.

(要約): It is well known that the distribution and magnitude of left ventricular (LV) hypertrophy are not uniform in patients with hypertrophic cardiomyopathy (HCM), which results in regional heterogeneity of LV early diastolic function. The advent of tissue Doppler imaging (TDI) has allowed the noninvasive evaluation of regional LV wall motion velocities. The aim of this study was to evaluate regional LV relaxation abnormalities and asynchrony noninvasively in patients with HCM by using pulsed and color-coded TDI. We studied 20 patients with asymmetric septal hypertrophy (HCM group) and 18 age-matched normal patients (control group). The peak early diastolic motion velocity (Ew) and time from the aortic component of the second heart sound to the peak of the Ew (II(A)-Ew) were measured by pulsed TDI. The myocardial velocity gradient during early diastole (MVG-Ew) also was measured by color-coded TDI. Mean values for these parameters were determined on the basis of measurements made at 2 sites of the ventricular septum or posterior wall at the levels of chordae tendineae and papillary muscles. The mean Ew and mean MVG-Ew for the ventricular septum and posterior wall were significantly lower, and mean II(A)-Ew was significantly prolonged in the HCM group compared with the control group. This difference was most pronounced in the hypertrophied ventricular septum of the HCM group. The standard deviations of II(A)-Ew for the ventricular septum and posterior wall were significantly greater in the HCM group than in the control group. The time constant of LV pressure decay during isovolumic diastole (tau) correlated inversely with Ew and MVG-Ew and correlated directly with II(A)-Ew. Furthermore, tau correlated directly with the standard deviation of the II(A)-Ew. LV early diastolic function in patients with HCM may be mediated by an augmentation of regional LV relaxation abnormalities and asynchrony.
(キーワード): Adult / Cardiac Catheterization / Cardiomyopathy, Hypertrophic / Diastole / Echocardiography, Doppler, Color / Echocardiography, Doppler, Pulsed / Female / Hemodynamics / Humans / Male / Predictive Value of Tests / Ventricular Dysfunction, Left
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0002-8703(00)90094-2
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10689265; ● Summary page in Scopus @ Elsevier: 2-s2.0-0034060533

(DOI: 10.1016/S0002-8703(00)90094-2, PubMed: 10689265, Elsevier: Scopus) Y Oishi, Tetsuzo Wakatsuki, A Nishikado, T Oki and Susumu Ito :
Circulating adhesion molecules and severity of coronary atherosclerosis,
Coronary Artery Disease, Vol.11, No.1, 77-81, 2000.

(要約): Circulating leukocytes are recruited at atherosclerotic sites through a family of adhesion molecules. Circulating forms of adhesion molecules in peripheral blood can be quantified now. To evaluate the relationship between circulating adhesion molecules and severity of coronary atherosclerosis. Subjects included 81 patients undergoing diagnostic coronary angiography, 12 of whom had normal coronary arteries (control group). The remaining 69 patients with demonstrable coronary atherosclerosis were divided into two groups by use of Gensini scores, namely mild atherosclerosis (n = 36, Gensini score 1-20) and severe atherosclerosis (n = 33, Gensini score > 20). Serum levels of circulating intercellular adhesion molecule-1 (ICAM-1), vascular cellular adhesion molecule-1 (VCAM-1), and E-selectin of groups measured before angiography were compared. Circulating levels of ICAM-1 in members of mild and severe atherosclerosis groups were significantly higher than those in members of the control group, whereas there was no significant difference among circulating levels of VCAM-1 in members of the three groups. Circulating levels of E-selectin in members of the mild atherosclerosis group were significantly higher than those in members of the severe atherosclerosis and control groups. These findings suggest that E-selectin is related to the early stage, and ICAM-1 is related to the advanced stage, of coronary atherosclerosis. With progression of atherosclerosis, one-step adhesion by ICAM-1 could become more important than multistep adhesion involving E-selectin, ICAM-1, and VCAM-1. These molecules may serve as markers for severity of coronary atherosclerosis.
(キーワード): Adult / Aged / Coronary Angiography / Coronary Artery Disease / E-Selectin / Female / Humans / Intercellular Adhesion Molecule-1 / Male / Middle Aged / Severity of Illness Index / Vascular Cell Adhesion Molecule-1
(出版サイトへのリンク): ● Publication site (DOI): 10.1097/00019501-200002000-00013
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10715810; ● Summary page in Scopus @ Elsevier: 2-s2.0-0034053039

(DOI: 10.1097/00019501-200002000-00013, PubMed: 10715810, Elsevier: Scopus) 水井佐和, 早渕康信, 森一博, 真鍋哲也, 多田羅勝義, 若槻哲三, 黒田𣳾弘 :
冠動脈攣縮性狭心症による胸痛を来たした無脾症候群の1例,
小児科臨床, Vol.53, No.1, 37-40, 2000年. Yuichiro Mishiro, Takashi Oki, Hirotsugu Yamada, Tetsuzo Wakatsuki and Susumu Ito :
Evaluation of left ventricular contraction abnormalities in patients with dilated cardiomyopathy with the use of pulsed tissue doppler imaging,
Journal of the American Society of Echocardiography, Vol.12, No.11, 913-920, 1999. Tetsuzo Wakatsuki, Takashi Oki, Koichi Sakabe, Hisanori Shinohara, Tomotsugu Tabata and Susumu Ito :
Coronary flow velocity immediately after reperfusion reflects myocardial microcirculation in canine models of acute myocardial infarction.,
Angiology, Vol.50, No.11, 919-928, 1999.

(要約): Recent reports indicate that the coronary microcirculation is sometimes injured, despite successful reperfusion in acute myocardial infarction (AMI). However, it is difficult to evaluate the coronary microcirculation immediately after reperfusion by using only angiography. The purpose of this study was to examine the relationship between the pattern of coronary blood flow velocity and myocardial microcirculatory injury immediately after reperfusion in AMI. The authors recorded the left circumflex coronary flow velocity by using the Doppler guide wire method 10 minutes after reperfusion in a canine model of AMI. In addition, myocardial contrast echocardiography was performed with the injection of contrast medium into the left circumflex coronary artery before clamping of the coronary artery and 15 minutes after release of the clamp. From these images, the ratio of the normalized gray-level postreperfusion to preclamping in the contrast-enhanced area was determined. It was compared with coronary flow velocity variables. In the 10 dogs with a diastolic-to-systolic velocity ratio (DSVR) < 4.0, this velocity ratio 10 minutes after reperfusion correlated positively (r = 0.75, p < 0.01) with the normalized gray-level ratio. However, the remaining three dogs with a DSVR > or = 4.0 markedly deviated from this pattern. Coronary flow velocities in the three dogs were characterized by a greater decrease in systolic flow velocity and occurrence of early systolic retrograde flow. Myocardial contrast echocardiographic images in these three dogs demonstrated a lower normalized gray-level ratio. In conclusion, the coronary flow velocity pattern immediately after reperfusion may reflect myocardial microcirculatory injury.
(キーワード): Albumins / Animals / Blood Flow Velocity / Contrast Media / Coronary Circulation / Dogs / Echocardiography / Echocardiography, Doppler / Microcirculation / Microspheres / Myocardial Infarction / Myocardial Reperfusion / Myocardial Reperfusion Injury
(出版サイトへのリンク): ● Publication site (DOI): 10.1177/000331979905001107
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10580357; ● Summary page in Scopus @ Elsevier: 2-s2.0-0032707749

(DOI: 10.1177/000331979905001107, PubMed: 10580357, Elsevier: Scopus) Yukiko Onose, Takashi Oki, Yuichiro Mishiro, Hirotsugu Yamada, Miho Abe, Kazuyo Manabe, Kageji Yoshimi, Tomotsugu Tabata, Tetsuzo Wakatsuki and Susumu Ito :
Influence of aging on systolic left ventricular wall motion velocities along the long and short axes in clinically normal patients determined by pulsed tissue Doppler imaging.,
Journal of the American Society of Echocardiography, Vol.12, No.11, 921-926, 1999. Hirotsugu Yamada, Takashi Oki, Yuichiro Mishiro, Tomotsugu Tabata, Miho Abe, Yukiko Onose, Tetsuzo Wakatsuki and Susumu Ito :
Effect of aging on diastolic left ventricular myocardial velocities measured by pulsed tissue Doppler imaging in healthy subjects.,
Journal of the American Society of Echocardiography, Vol.12, No.7, 574-581, 1999. Takashi Oki, Kazuyo Fukuda, Tomotsugu Tabata, Yuichiro Mishiro, Hirotsugu Yamada, Miho Abe, Yukiko Onose, Tetsuzo Wakatsuki, Arata Iuchi and Susumu Ito :
Effect of an acute increase in afterload on left ventricular regional wall motion velocity in healthy subjects.,
Journal of the American Society of Echocardiography, Vol.12, No.6, 476-483, 1999. Takashi Oki, Tomotsugu Tabata, Yuichiro Mishiro, Hirotsugu Yamada, Miho Abe, Yukiko Onose, Tetsuzo Wakatsuki, Arata Iuchi and Susumu Ito :
Pulsed tissue Doppler imaging of left ventricular systolic and diastolic motion velocities to evaluate differences between long and short axes in healthy subjects.,
Journal of the American Society of Echocardiography, Vol.12, No.5, 308-313, 1999. Takashi Oki, Arata Iuchi, Tomotsugu Tabata, Yuichiro Mishiro, Hirotsugu Yamada, Miho Abe, Yukiko Onose, Tetsuzo Wakatsuki and Susumu Ito :
Left ventricular systolic wall motion velocities along the long and short axis measured by pulsed tissue Doppler imaging in patients with atrial fibrillation.,
Journal of the American Society of Echocardiography, Vol.12, No.2, 121-128, 1999. M Takakura, T Harada, H Fukuno, H Okushi, T Taniguchi, Sachi Sawada, H Fujinaga, Tetsuzo Wakatsuki and Takashi Oki :
Echocardiographic detection of occult cor pulmonale during exercise in patients with chronic obstructive pulmonary disease,
Echocardiography, Vol.16, 127-134, 1999. Miho Abe, Takashi Oki, Tomotsugu Tabata, Hirotsugu Yamada, Yukiko Onose, Masako Matsuoka, Yuichiro Mishiro, Tetsuzo Wakatsuki and Susumu Ito :
Evaluation of the hemodynamic relationship between the left atrium and left ventricle during atrial systole by pulsed tissue Doppler imaging in patients with left heart failure.,
Japanese Circulation Journal, Vol.63, No.10, 763-769, 1999. Hirotsugu Yamada, Takashi Oki, Tomotsugu Tabata, Yuichiro Mishiro, Miho Abe, Yukiko Onose, Tetsuzo Wakatsuki, Arata Iuchi and Susumu Ito :
Assessment of the systolic left ventricular myocardial velocity profile and gradient using tissue Doppler imaging in patients with hypertrophic cardiomyopathy.,
Echocardiography, Vol.16, 775-783, 1999. Tetsuzo Wakatsuki :
Coronary flow velocity immediately after reperfusion reflects myocardial microcirculation in canine models of acute myocardial infarction,
Angiology, Vol.50, 919-928, 1999. Takashi Oki, Tomotsugu Tabata, Hirotsugu Yamada, Tetsuzo Wakatsuki, Yuichiro Mishiro, Miho Abe, Yukiko Onose, Arata Iuchi and Susumu Ito :
Left ventricular diastolic properties of hypertensive patients measured by pulsed tissue Doppler imaging.,
Journal of the American Society of Echocardiography, Vol.11, No.12, 1106-1112, 1998. Takashi Oki, Tomotsugu Tabata, Hirotsugu Yamada, Kazuyo Fukuda, Miho Abe, Yukiko Onose, Tetsuzo Wakatsuki, Arata Iuchi and Susumu Ito :
Assessment of abnormal left atrial relaxation by transesophageal pulsed Doppler echocardiography of pulmonary venous flow velocity.,
Clinical Cardiology, Vol.21, No.10, 753-758, 1998. Tetsuzo Wakatsuki :
The pattern of alteration in flow velocity in the recanalized artery is related to left ventricular recovery in patients with acute infarction and successful direct balloon angioplasty,
Journal of the American College of Cardiology, Vol.32, No.2, 338-344, 1998.

(要約): We evaluated the relationship between alterations in coronary flow velocity during the acute phase of acute myocardial infarction (AMI) and the recovery of left ventricular wall motion in patients who underwent successful primary angioplasty. The status of the coronary microcirculation is the major determinant of the prognosis of patients who have had successful reperfusion after AMI. Animal studies have shown that dynamic changes in regional flow are associated with the extent of infarction. Evaluation of alterations in coronary flow velocity in infarcted arteries may provide information about microcirculatory damage. Flow velocity of the distal anterior descending artery was continuously monitored with the use of a Doppler guide wire immediately after recanalization for 18 +/- 4 h in 19 patients who underwent successful primary angioplasty after anterior AMI. Subjects were divided into two groups on the basis of the time course of alterations in average peak velocity (APV). Group D consisted of patients who had progressive decreases in APV through the next day (n = 9), and Group I comprised patients with an increase in APV after a transient decline (n = 10). Ejection fraction (EF) and regional wall motion (RWM) were assessed by left ventriculography performed on admission and at discharge. The APV at the end of monitoring was greater in group I than in group D. In group I, EF and RWM were significantly improved at discharge. The change in EF was greater in group I than in group D (17 +/- 9% vs. 4 +/- 9%, p = 0.007), as was the change in RWM (0.96 +/- 0.23 vs. 0.13 +/- 0.36 SD/chord, p < 0.0001). The alteration in flow velocity in recanalized infarcted arteries is related to left ventricular recovery. A progressive decrease in velocity after angioplasty implies no reflow, which is associated with a poor recovery of left ventricular function. Reperfusion injury may account in part for this phenomenon.
(キーワード): Aged / Angioplasty, Balloon / Blood Flow Velocity / Coronary Angiography / Coronary Circulation / Coronary Vessels / Female / Follow-Up Studies / Gated Blood-Pool Imaging / Humans / Male / Microcirculation / Middle Aged / Myocardial Contraction / Myocardial Infarction / Myocardial Reperfusion Injury / Prognosis / Stroke Volume / Ultrasonography, Doppler / Ultrasonography, Interventional / Ventricular Function, Left
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0735-1097(98)00228-9
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 9708458; ● Search Scopus @ Elsevier (PMID): 9708458; ● Search Scopus @ Elsevier (DOI): 10.1016/S0735-1097(98)00228-9

(DOI: 10.1016/S0735-1097(98)00228-9, PubMed: 9708458) H Shinohara, Akiyoshi Nishikado, Tetsuzo Wakatsuki, Koichi Sakabe and Susumu Ito :
The Effects of Nicorandil on Electrophysiological Changes in Acute Myocardial Ischemia and Reperfusion,
Japanese Heart Journal, Vol.39, No.3, 363-373, 1998. Takashi Oki, Tomotsugu Tabata, Hirotsugu Yamada, Tetsuzo Wakatsuki, Kazuyo Fukuda, Miho Abe, Yukiko Onose, Arata Iuchi, Nobuo Fukuda and Susumu Ito :
Evaluation of left atrial filling using systolic pulmonary venous flow velocity measurements in patients with atrial fibrillation.,
Clinical Cardiology, Vol.21, No.3, 169-175, 1998. Takashi Oki, Tomotsugu Tabata, Hirotsugu Yamada, Miho Abe, Yukiko Onose, Tetsuzo Wakatsuki, Hiroyuki Fujinaga, Koichi Sakabe, Jiro Ikata, Akiyoshi Nishikado, Arata Iuchi and Susumu Ito :
Right and left ventricular wall motion velocities as diagnostic indicators of constrictive pericarditis.,
The American Journal of Cardiology, Vol.81, No.4, 465-470, 1998. Koichi Sakabe, Akiyoshi Nishikado, Tetsuzo Wakatsuki, Takashi Oki and Susumu Ito :
Right atrial potential profiles during atrial fibrillation predict the success of atrial defibrillation,
Journal of Electrocardiology, Vol.31, No.1, 39-44, 1998.

(要約): The right atrial electric potential was measured in 29 patients with chronic atrial fibrillation, and the clinical utility of these measurements in predicting the success of atrial defibrillation was investigated. The endocardial electric potential was recorded at 12 sites within the right atrium (high, middle, and low loci of anterior, posterior, lateral, and medial sites of the right atrium) with an electrode catheter. The duration and polar displacement of the atrial waves were measured at the one site that showed the maximum atrial electric potential among the 12 sites. The ratio of the maximum to the minimum atrial electric potential (atrial wave ratio) was calculated. Patients were classified into two groups according to the success (n = 6) or failure (n = 23) of atrial defibrillation. Electrophysiologic data were compared between the two groups, and correlations were evaluated between the data and the maximal left atrial diameter obtained from M-mode echocardiography. The two groups did not differ in the duration and polar displacement of the atrial waves. However, the atrial wave ratio was significantly lower in the success group than in the failure group, and the success rate of atrial defibrillation was also significantly greater in the patients with an atrial wave ratio of 10 or lower. This ratio showed a positive correlation with the maximal left atrial diameter; it became more difficult to achieve atrial defibrillation as the atrial wave ratio increased. Thus, the right atrial electric potential profile of patients with atrial fibrillation is a useful predictor of the success of atrial defibrillation.
(キーワード): Adolescent / Adult / Aged / Atrial Fibrillation / Atrial Function, Right / Chronic Disease / Electric Countershock / Electrocardiography / Electrophysiology / Female / Humans / Male / Middle Aged / Prognosis
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0022-0736(98)90005-X
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 9533376; ● Search Scopus @ Elsevier (PMID): 9533376; ● Search Scopus @ Elsevier (DOI): 10.1016/S0022-0736(98)90005-X

(DOI: 10.1016/S0022-0736(98)90005-X, PubMed: 9533376) H Fujinaga, Tetsuzo Wakatsuki, Koichi Sakabe, Jiro Ikata, Hirotsugu Yamada, Akiyoshi Nishikado, Takashi Oki and Susumu Ito :
Characteristics of Coronary Flow Velocity in Constrictive Pericarditis,
Catheterization and Cardiovascular Diagnosis, Vol.44, 61-64, 1998. H Fujinaga, Tetsuzo Wakatsuki, A Nishikado, T Oki and Susumu Ito :
Electrophysiologic effects of quinaprilat in dogs during acute myocardial ischemia and following reperfusion.,
Coronary Artery Disease, Vol.9, No.10, 697-701, 1998.

(要約): There have been few studies concerning the electrophysiologic changes associated with the use of angiotensin-converting enzyme inhibitors in patients with acute myocardial infarction. We examined the electrophysiologic effects of quinaprilat in dogs during acute myocardial ischemia and following reperfusion. The left anterior descending coronary artery was occluded for 10 min and reperfused for 10 min. Animals received intravenous quinaprilat (3 micrograms/kg per min, quinaprilat group) or saline (control group). We measured the ventricular effective refractory period and intra-myocardial conduction time within the left anterior descending coronary artery region (ischemic region) during myocardial ischemia and following reperfusion, and determined the frequency of ventricular fibrillation. The effective refractory period in the ischemic region decreased during myocardial ischemia and decreased further immediately after reperfusion in the control group. The intra-myocardial conduction time in the ischemic region increased during myocardial ischemia but rapidly shortened after reperfusion in the control group. In the quinaprilat group, however, no significant differences were evident between the ischemic and non-ischemic regions in either the effective refractory period or the intra-myocardial conduction time during myocardial ischemia or following reperfusion. The percentage shortening of the effective refractory period and the percentage prolongation of the intra-myocardial conduction time in the ischemic region were significantly lower in the quinaprilat group than in the control group during myocardial ischemia and following reperfusion. The frequency of ventricular fibrillation during myocardial ischemia and following reperfusion was significantly lower in the quinaprilat group (21%) than in the control group (74%; P < 0.01). Quinaprilat protects against electrophysiologic abnormalities, and may decrease arrhythmias during acute myocardial ischemia and following reperfusion.
(キーワード): Acute Disease / Angiotensin-Converting Enzyme Inhibitors / Animals / Disease Models, Animal / Dogs / Electrocardiography / Heart Conduction System / Heart Rate / Injections, Intravenous / Isoquinolines / 心筋虚血 (myocardial ischemia) / Myocardial Reperfusion / Tetrahydroisoquinolines / Ventricular Fibrillation
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 9894622; ● Search Scopus @ Elsevier (PMID): 9894622

(PubMed: 9894622) Tetsuzo Wakatsuki :
Characteristics of coronary flow velocity in constrictive pericarditis,
Cathet Cardiovasc Diagn, Vol.44, 61-64, 1998. K. Sakabe, Tetsuzo Wakatsuki, H. Shinohara, J. Ikata, H. Fujinaga, Y. Oishi, T. Toyoshima, A. Nishikado, T. Oki and Susumu Ito :
Coronary flow velocity patterns immediately after reperfusion reflect pathologic characteristics of reperfused myocardium in canine models of acute myocardial infarction,
Coronary Artery Disease, Vol.9, No.1, 21-27, 1998.

(要約): It is difficult to evaluate the extent of myocardial injury after successful reperfusion following acute myocardial infarction (AMI). We investigated the relationship between the coronary flow velocity pattern immediately after reperfusion and pathologic characteristics after myocardial reperfusion injury in dogs. We measured distal coronary flow velocity variables in the left circumflex coronary artery in a canine model of AMI (n = 12) 10 min after the release of a clamp (3-10 h clamp procedure) using a 0.35 mm Doppler guide-wire. Dogs were divided into two groups according to presence or absence of early systolic retrograde coronary flow. Hearts were excised 2 h after reperfusion and examined histopathologically. The clamping time tended to be longer in dogs with early systolic retrograde coronary flow. Neutrophil infiltration was observed in the myocardium of dogs without systolic retrograde flow (n = 9); hemorrhage was rarely detectable and the myocardium maintained a bundle form. However, the bundle form of the myocardium became rough, and the severity of the incidence of hemorrhage tended to increase as the ratio of the diastolic coronary flow velocity to systolic velocity (DSVR) decreased. Vacuolar degeneration of the myocardium was also observed in hearts with a relatively low DSVR. In the group with systolic retrograde flow (n = 3), hearts were characterized by coagulation necrosis, marked vacuolar degeneration of the myocardium and diffusely distributed red cells in the intermyocytes. Systolic antegrade flow velocity was much reduced in this group, resulting in a markedly increased DSVR. These findings appeared to be related to severe myocardial damage. Coronary flow velocity patterns immediately after successful reperfusion appear to reflect the pathologic characteristics of the reperfused myocardium in dogs with AMI.
(キーワード): Animals / Blood Flow Velocity / Coronary Circulation / Dogs / Myocardial Infarction / Myocardial Reperfusion / Myocardial Reperfusion Injury / Myocardium / Time Factors / Ultrasonography
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 9589187; ● Search Scopus @ Elsevier (PMID): 9589187

(PubMed: 9589187) Takashi Oki, Tomotsugu Tabata, Hirotsugu Yamada, Tetsuzo Wakatsuki, Hisanori Shinohara, Akiyoshi Nishikado, Arata Iuchi, Nobuo Fukuda and Susumu Ito :
Clinical application of pulsed Doppler tissue imaging for assessing abnormal left ventricular relaxation.,
The American Journal of Cardiology, Vol.79, No.7, 921-928, 1997. 酒部宏一, 西角彰良, 若槻哲三, 篠原尚典, 井形次郎, 阿部美保, 由岐中道子, 山田博胤, 田畑智継, 野村昌弘, 井内新, 大木崇, 伊東進 :
単冠動脈症を合併した肥大型心筋症の1例,
呼吸と循環, Vol.45, No.4, 395-398, 1997年. Masato Nakamura, Taro Tsunoda, Tetsuzo Wakatsuki, Katsuto Ui, Toshiyuki Degawa, So Yabuki and Tetsu Yamaguchi :
Safety and feasibility of continuous monitoring of coronary flow velocity in acute myocardial infarction by Doppler guide wire,
American Heart Journal, Vol.132, No.3, 567-571, 1996. Masato Nakamura, Taro Tsunoda, Tetsuzo Wakatsuki, Katsuto Ui, Toshiyuki Degawa, So Yabuki and Tetsu Yamaguchi :
Distal coronary flow velocity immediately after direct angioplasty for acute myocardial infarction,
American Heart Journal, Vol.132, No.2 Part 1, 251-257, 1996. Tetsuzo Wakatsuki :
Efficacy of coronary angioplasty with a cutting balloon in a case of repeated coronary stenosis,
The Tokushima Journal of Experimental Medicine, Vol.43, 167-172, 1996. Masahiro Nomura, Yutaka Nakaya, Ken Saito, F Kishi, Tetsuzo Wakatsuki, Hirokazu Miyoshi, Akiyoshi Nishikado, Shigenobu Bando, Susumu Ito, Hiromu Nishitani, Masao Wada, Satoshi Fujita and Itsuro Tamura :
Noninvasive localization of accessory pathways by magnetocardiographic imaging,
Clinical Cardiology, Vol.17, No.5, 239-244, 1994.

(要約): The magnetocardiogram (MCG) is a newly developed method that helps localize a cardiac current source. To test the clinical accuracy of a 7-channel biomagnetic system in the localization of early ventricular depolarization sites, the MCGs of 14 patients with Wolff-Parkinson-White (WPW) syndrome were recorded in a radiofrequency-shielded room. The locations of early ventricular depolarization sites were classified by standard 12-lead electrocardiograms (ECGs) and body surface isopotential mapping. The accessory pathways of 3 patients with WPW syndrome were located in the right free wall and in 11 patients in the left free wall. The three-dimensional (3-D) dipole location was computed every 2 ms from the onset of the QRS complex by the least-square method. These 3-D dipole locations were projected onto a gated magnetic resonance image in order to visualize the propagation of the calculated ventricular source. The results were compared with those obtained by body surface isopotential mapping, and electrocardiographic and electrophysiologic studies. The location of the deduced current dipole at 20 ms correlated well with the location of the accessory pathway by the body surface mappings in 12 of the 14 patients with WPW syndrome. The MCG is capable of precisely determining the 3-D location of a current source in a noninvasive manner and may be of potential benefit in the treatment of WPW syndrome by catheter ablation.
(キーワード): magnetocardiogram / Wolff-Parkinson-White syndrome / Magnetic resonance image
(出版サイトへのリンク): ● Publication site (DOI): 10.1002/clc.4960170504
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 8004837; ● Search Scopus @ Elsevier (PMID): 8004837; ● Search Scopus @ Elsevier (DOI): 10.1002/clc.4960170504

(DOI: 10.1002/clc.4960170504, PubMed: 8004837) Ken Saito, Yutaka Nakaya, Y Miyoshi, Tetsuzo Wakatsuki, M. Nomura and Masayuki Shono :
Effects of vesnarinone (OPC-8212) on Ca(2+)-activated K channels and cytosolic Ca2+ in cultured smooth muscle cells from porcine coronary artery.,
Japanese Heart Journal, Vol.35, No.1, 61-71, 1994.

(要約): Vesnarinone is a new, non vasodilating cardiotonic agent. This study compared the effects of vesnarinone and amrinone, a phosphodiesterase (PDE) inhibitors with vasodilating actions, on cultured smooth muscle cells from the porcine coronary artery. Application of vesnarinone (10(-4) M) or amrinone (10(-4) M) to the bath solution in cell-attached patches activated the KCa channel having a conductance of 133 pS (bath 2.7 mM K, pipette 140 mM K). Application of vesnarinone to the cytosolic side had no direct effect on KCa channel activities in inside-out patches. Activation of the KCa channel was suppressed when the intracellular production of cAMP was suppressed by preincubation with carbachol (10(-6) M). Amrinone, but not vesnarinone, lowered [Ca2+]i in the K(+)-depolarized smooth muscle cells (K+ = 70 mM). These results suggest that vesnarinone exerts an additional effect on [Ca2+]i that is independent of PDE inhibition. The difference in the effects on [Ca2+]i in vascular smooth muscle cells may explain in part the differing actions of these agents on vascular relaxation.
(キーワード): smooth muscle / cytosolic Ca2
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 8201782; ● Search Scopus @ Elsevier (PMID): 8201782

(PubMed: 8201782) Ken Saito, Yutaka Nakaya, Yukiko Miyoshi, Tetsuzo Wakatsuki, Masahiro Nomura and M Shono :
Effects of Vesnarinone(OPC-8212)on Ca²⁺-Activated K Channels and Cytosolic Ca²⁺- in Cultured Smooth Muscle Cells from Porcine Coronary Artery,
Japanese Heart Journal, Vol.35, No.1, 61-71, 1994.

(キーワード): Vesnarinone / Amrinone / Positive inotropic agents / Kca channel / [Ca2+]i

野村昌弘, 中屋豊, 若槻哲三, 三好由貴子, 岸史子, 齋藤憲, 伊東進, 中安紀美子, 西谷弘, 松崎健司, 上野慎一, 田村逸郎, 和田昌夫, 藤田智, 高江勉 :
心臓磁界測定による心室性期外収縮の心室最早期興奮部位の推定,
心臓, Vol.25, No.8, 907-913, 1993年.

(要約): 心磁図による診断法を確立するために，生体内の電流源を三次元的に推定する心磁図法と，心電図同期MRI断層法を併用して，心室性期外収縮発生源の位置を推定した．推定された値は，体表面電位図法から推定される発生源とほぼ一致し，診断学的にも有用であることがわかった．
(キーワード): 心磁図 / 心室性期外収縮 / MRI

野村昌弘, 吉栖正典, 石村泰子, 増田裕, 水口和生, 中屋豊, 大内武, 加藤逸夫, 岡源郎, 日比野敏行, 三好由貴子, 若槻哲三, 大木崇, 伊東進 :
マラソン前後における血中遊離型および硫酸抱合型カテコラミンの変動,
心臓, Vol.25, No.Suppl 2, 97-99, 1993年.

(出版サイトへのリンク): ● Publication site (DOI): 10.11281/shinzo1969.25.Supplement2_97
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390001205485924224; ● Search Scopus @ Elsevier (DOI): 10.11281/shinzo1969.25.Supplement2_97

(DOI: 10.11281/shinzo1969.25.Supplement2_97, CiNii: 1390001205485924224) 中屋豊, 野村昌弘, 三好由貴子, 若槻哲三, 齋藤憲, 上野慎一, 松崎健司, 西谷弘 :
7チャンネルSQUID磁束計による心臓磁界計測およびdipoleの位置推定,
日本臨床生理学会誌, Vol.23, 359-369, 1993年. Masahiro Nomura, Kimiko Nakayasu, Yutaka Nakaya, Yukiko Miyoshi, Tetsuzo Wakatsuki, Ken Saito, Shigenobu Bando and Susumu Ito :
Single moving dipole obtained from magnetic field of the heart in patients with left ventricular hypertrophy,
Clinical Cardiology, Vol.15, No.10, 752-758, 1992.

(要約): Single moving dipole法により，高血圧，僧帽弁閉鎖不全，大動脈弁狭窄の症例について，推定dipoleの値を経時的定量的に求めた．健常例との比較により診断率の精度を比較検討し，各疾患の特徴と診断基準を明らかにした．
(キーワード): magnetocardiogram / left ventricular overload / single moving dipole
(出版サイトへのリンク): ● Publication site (DOI): 10.1002/clc.4960151013
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 1395186; ● Search Scopus @ Elsevier (PMID): 1395186; ● Search Scopus @ Elsevier (DOI): 10.1002/clc.4960151013

(DOI: 10.1002/clc.4960151013, PubMed: 1395186) Tetsuzo Wakatsuki, Yutaka Nakaya and Isao Inoue :
Vasopressin modulates K(+)-channel activities of cultured smooth muscle cells from porcine coronary artery,
American Journal of Physiology, Heart and Circulatory Physiology, Vol.263, No.2, H491-H496, 1992. Yukiko Miyoshi, Yutaka Nakaya, Tetsuzo Wakatsuki, Shuichiro Nakaya, Kazuya Fujino, Ken Saito and Isao Inoue :
Endothelin blocks ATP-sensitive K+ channels and depolarizes smooth muscle cells of porcine coronary artery,
Circulation Research, Vol.70, No.3, 612-616, 1992. 中屋豊, 野村昌弘, 若槻哲三, 三好由貴子, 西角彰良, 坂東重信, 伊東進, 中安紀美子 :
Single moving dipoleによる左室負荷の診断,
日本心電学会誌, Vol.12, No.Suppl 1, 85-87, 1992年. 野村昌弘, 中屋豊, 三好由貴子, 若槻哲三, 伊東進, 森博愛, 上野慎一, 松崎健司, 西谷弘, 田村逸郎, 和田昌夫, 藤田智, 高江勉 :
正常例の初期QRS波のdipoleの位置推定‐心電図同期MRI画像上への表示‐,
日本生体磁気学会誌, Vol.5, 110-113, 1992年. 野村昌弘, 中屋豊, 三好由貴子, 若槻哲三, 伊東進, 森博愛, 上野慎一, 松崎健司, 西谷弘, 田村逸郎, 和田昌夫, 藤田智, 高江勉 :
心磁図法による心室最早期興奮部位の推定‐磁界分布図と体表面電位図·心表面マッピングとの対比‐,
日本生体磁気学会誌, Vol.5, 106-109, 1992年. Tetsuzo Wakatsuki :
Effects of vasopressin on ATP-sensitive and Ca²⁺-activated K⁺ channels of coronary arterial smooth muscle cells,
The Japanese Journal of Pharmacology, Vol.58, 339P, 1992. Tetsuzo Wakatsuki, Yutaka Nakaya, Yukiko Miyoshi, Masahiro Nomura, Ken Saito, RX Zeng, Susumu Ito and Isao Inoue :
Effects of vasopressin on K+ channels of vascular smooth muscle cells,
Therap Res, Vol.13, 311-317, 1992. 三好由貴子, 中矢修一朗, 若槻哲三, 藤野和也, 齋藤憲, 中屋豊, 井上勲 :
冠動脈平滑筋細胞におけるEndothelinの作用,
Therapeutic Research, Vol.12, No.6, 121-126, 1991年.

(キーワード): ATP sensitive K channel / Smooth music cells / Endothelin / Nicorandil

Kazuya Fujino, Shuichiro Nakaya, Tetsuzo Wakatsuki, Yukiko Miyoshi, Yutaka Nakaya, Hiroyoshi Mori and Isao Inoue :
Effects of nitroglycerin on ATP-induced Ca(++)-mobilization, Ca(++)-activated K channels and contraction of cultured smooth muscle cells of porcine coronary artery,
The Journal of Pharmacology and Experimental Therapeutics, Vol.256, No.1, 371-377, 1991. Hideaki Nii, Yutaka Nakaya, Shuichiro Nakaya, Tetsuzo Wakatsuki, Yukiko Miyoshi, Hirohumi Yamamoto, Akiyoshi Nishikado, Kazuya Fujino, Shigenobu Bando and Hiroyoshi Mori :
Alteration of Strength-Interval Relation by Class I Antiarrhythmic Drugs in Normal and K-Depolarized Cardiac Muscle Fibers,
Jpn J Appl Physiol(Japanese journal of applied physiology), Vol.20, No.5, 351-358, 1990.

MISC

Issei Yagi, Shusuke Yagi, Keisuke Nakanishi, Kazuki Tezuka, K Matsuyama, Y Aibara, T Ishida, H Yoneda, M Yamamoto, Takayuki Ise, Koji Yamaguchi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Tetsuya Kitagawa, Yasuhiko Nishioka and Masataka Sata :
Critical Limb Threatening Ischemia Due to Severe Polyarteritis Nodosa-A Case Report,
Internal Medicine, 2024.

(要約): A delayed diagnosis of polyarteritis nodosa may lead to critical limb-threatening ischemia (CLTI). A 74-year-old woman presented with left-foot pain and was treated with oral vasodilators and antiplatelet agents. However, the distal ischemia progressed to CLTI, including gangrene of the fingers and toes, and bilateral foot dropping appeared because of peroneal nerve paralysis. Angiography of the extremities revealed obstruction and stenosis of medium-sized arteries. Based on the progressive distal gangrene, mononeuropathy multiplex, and pathological findings of necrotic vasculitis, polyarteritis nodosa was diagnosed, and the patient's condition improved. A biopsy and neurological examination are essential for the appropriate diagnosis of PAN and immediate treatment.
(徳島大学機関リポジトリ): ● Metadata: 119631
(出版サイトへのリンク): ● Publication site (DOI): 10.2169/internalmedicine.4149-24
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 39370254; ● Search Scopus @ Elsevier (PMID): 39370254; ● Search Scopus @ Elsevier (DOI): 10.2169/internalmedicine.4149-24

(徳島大学機関リポジトリ: 119631, DOI: 10.2169/internalmedicine.4149-24, PubMed: 39370254) TOMONORI Takahashi, Tetsuzo Wakatsuki, Takayuki Ise and Masataka Sata :
Spontaneous thrombosis of a giant aneurysm complicated with the coronary-to-pulmonary artery fistula: a case report,
European Heart Journal. Case Reports, Vol.8, No.5, ytae227, 2024.

(徳島大学機関リポジトリ): ● Metadata: 119332
(出版サイトへのリンク): ● Publication site (DOI): 10.1093/ehjcr/ytae227
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38736999; ● Search Scopus @ Elsevier (PMID): 38736999; ● Search Scopus @ Elsevier (DOI): 10.1093/ehjcr/ytae227

(徳島大学機関リポジトリ: 119332, DOI: 10.1093/ehjcr/ytae227, PubMed: 38736999) T Niki, Takeshi Soeki, Kenya Kusunose, K Yamaguchi, K Koshiba, Tomohito Kawano, Hirotsugu Yamada, Tetsuzo Wakatsuki and Kenji Kangawa :
Elevated Concentration of Interferon-Inducible Protein of 10kd (IP-10) is Associated with Coronary Atherosclerosis.,
Circulation Journal, Vol.72, No.0, 715_OJ233, 2008.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1571698602189478144

(CiNii: 1571698602189478144) K Yamaguchi, Tetsuzo Wakatsuki, Kenya Kusunose, T Niki, K Koshiba, Tomohito Kawano, Hirotsugu Yamada and Takeshi Soeki :
Predictors of Local Hypercoagulability after Sirolimus-Eluting Stent Implantation: Implication for Correlates of Late Stent Thrombosis.,
Circulation Journal, Vol.72, No.0, 249_FRS022, 2008.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1572543027118467968

(CiNii: 1572543027118467968) Takeshi Soeki, T Niki, K Koshiba, Kenya Kusunose, K Yamaguchi, Tomohito Kawano, Hirotsugu Yamada and Tetsuzo Wakatsuki :
Elevated Concentration of Pentraxin 3 is Associated with Coronary Plaque Vulnerability.,
Circulation Journal, Vol.72, No.0, 632_PE499, 2008.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1573105977073314048

(CiNii: 1573105977073314048) Takeshi Soeki, K Koshiba, T Niki, Kenya Kusunose, K Yamaguchi, Tomohito Kawano, Hirotsugu Yamada, Tetsuzo Wakatsuki and Kenji Kangawa :
Ghrelin Attenuates Myocardial Ischemia/Reperfusion Injury via the Extracellular Signal-Regulated Kinase 1/2 and Phosphatidylinositol.,
Circulation Journal, Vol.72, No.0, 145_OE022, 2008.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1571135652234960512

(CiNii: 1571135652234960512) Tetsuzo Wakatsuki, K Yamaguchi, T Niki, Kenya Kusunose, K Koshiba, Takeshi Soeki and Hirotsugu Yamada :
Long-Term Local Inflammatory Response after Coronary Artery Stenting with Drug-Eluting Stent.,
Circulation Journal, Vol.72, 421_PJ456, 2008.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1572824502094771072

(CiNii: 1572824502094771072) Kenya Kusunose, Hirotsugu Yamada, A Iga, T Niki, K Yamaguchi, K Koshiba, Takeshi Soeki and Tetsuzo Wakatsuki :
Left Atrial Volume does not reflect Brain Natriuretic Peptide Levels in Patients with Atrial Fibrillation.,
Circulation Journal, Vol.72, 508_PE367, 2008.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1570009752328732544

(CiNii: 1570009752328732544) Kenya Kusunose, Hirotsugu Yamada, A Iga, T Niki, K Yamaguchi, K Koshiba, Takeshi Soeki and Tetsuzo Wakatsuki :
Importance of Left Atrial Function for the Pseudonormalization of Transmitral Flow Velocity Pattern in Patients with Hypertrophic Cardiomyopathy.,
Circulation Journal, Vol.72, 426_PJ492, 2008.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1572261552141358592

(CiNii: 1572261552141358592) Hirotsugu Yamada, Kenya Kusunose, A Iga, T Niki, K Yamaguchi, K Koshiba, Takeshi Soeki and Tetsuzo Wakatsuki :
E/e' as a Predictor of the Cardiac Response to Increment of Preload in Patients with Atrial Fibrillation.,
Circulation Journal, Vol.72, No.0, S_749, 2008.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1572261552141499008

(CiNii: 1572261552141499008) Tetsuzo Wakatsuki, K Yamaguchi, T Niki, Kenya Kusunose, K Koshiba, Hirotsugu Yamada, Takeshi Soeki, Shusuke Yagi, Takashi Iwase, Masashi Akaike and Masataka Sata :
Long-term endothelial dysfunction after coronary artery stenting with drug-eluting stent associated with local inflammatory response.,
Circulation, Vol.118, S_749, 2008. K Yamaguchi, Tetsuzo Wakatsuki, T Niki, Kenya Kusunose, K Koshiba, Shusuke Yagi, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Local hypercoagulability and endothelial dysfunction after sirolimus-eluting stent implantation: implication for late stent thrombosis.,
Circulation, Vol.118, S_651, 2008. Takeshi Soeki, T Niki, K Koshiba, Kenya Kusunose, K Yamaguchi, Hirotsugu Yamada and Tetsuzo Wakatsuki :
Elevated concentration of Pentraxin 3 is associated with coronary plaque vulnerability.,
Eur Heart J, Vol.29, 505-732, 2008. Tetsuzo Wakatsuki, K Yamaguchi, Kenya Kusunose, T Niki, K Koshiba, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Long-term local inflammatory response after coronary artery stenting with drug-eluting stent.,
Eur Heart J, Vol.29, 505-732, 2008. K Koshiba, Takeshi Soeki, T Niki, Kenya Kusunose, H Yamaguchi, Hirotsugu Yamada and Tetsuzo Wakatsuki :
C-type natriuretic peptide ameliorates the progression of experimental autommune myocarditis.,
Eur Heart J, Vol.29, 505-732, 2008. S Nishio, Hirotsugu Yamada, H Motonari, H Okada, Kenya Kusunose, Y Tadatsu, M Sato, H Hiraoka, H Kawano, Takeshi Soeki, Tetsuzo Wakatsuki and Masashi Akaike :
Assessment of Left Atrial Ejection Force in Patients with Hypertensive Heart Disease.,
Journal of the American Society of Echocardiography, Vol.21, 552, 2008. Kenya Kusunose, Hirotsugu Yamada, S Nishio, M Sato, H Hiraoka, H Kawano, Y Tadatsu, Takeshi Soeki, Tetsuzo Wakatsuki and Masashi Akaike :
Importance of Left Atrial Function in Cardiac Response to Increment of Preload in Patients with Old Myocardial Infarction: Assessment by Automated Left Atrial Volume Tracking Method.,
Journal of the American Society of Echocardiography, Vol.21, 552, 2008. S Nishio, Hirotsugu Yamada, H Motonari, Kenya Kusunose, Y Tadatsu, M Sato, H Hiraoka, H Kawano, Takeshi Soeki, Tetsuzo Wakatsuki and Masashi Akaike :
Beat-To-Beat Variation of Mitral Annular Velocities in Atrial Fibrillation.,
Journal of the American Society of Echocardiography, Vol.21, 550, 2008. Hirotsugu Yamada, Kenya Kusunose, S Nishio, Y Tadatsu, M Sato, H Hiraoka, H Kawano, T Niki, K Yamaguchi, K Koshiba, Takeshi Soeki, Tetsuzo Wakatsuki and Masashi Akaike :
The Mitral L-Wave Predicts the Cardiac Response to Preload Increment in Atrial Fibrillation.,
Journal of the American Society of Echocardiography, Vol.21, 545, 2008. S Nishio, Hirotsugu Yamada, H Motonari, Kenya Kusunose, Y Tadatsu, M Sato, H Hiraoka, H Kawano, T Niki, K Yamaguchi, K Koshiba, Takeshi Soeki, Tetsuzo Wakatsuki and Masashi Akaike :
Usefulness of Tei Index in Atrial Fibrillation: Assessment by Dual Doppler Echocardiography.,
Journal of the American Society of Echocardiography, Vol.21, 543, 2008. Kenya Kusunose, K Takechi, Hirotsugu Yamada, S Nishio, Y Tadatsu, T Niki, K Yamaguchi, K Koshiba, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike, M Choraku and Y Maeda :
Multicenter Trial for the Validation of Automated Function Imaging in Patients with Local Left Ventricular Asynergy (VANILLA Study).,
Journal of the American Society of Echocardiography, Vol.21, 538, 2008. Kenya Kusunose, Hirotsugu Yamada, S Nishio, T Niki, K Yamaguchi, K Koshiba, Takeshi Soeki, Tetsuzo Wakatsuki and Masashi Akaike :
Role of Left Atrial Function for Pseudonormalization of Transmitral Flow Velocity Pattern in Patients with Hypertrophic Cardiomyopathy.,
Journal of the American Society of Echocardiography, Vol.21, 524, 2008. Hirotsugu Yamada, Kenya Kusunose, Y Uzuuchi, H Niki, T Nakajima, K Yamaguchi, K Koshiba, Tomohito Kawano, Takeshi Soeki and Tetsuzo Wakatsuki :
Assessment of the cardiac response to increment of preload in patients with atrial fibrillation using dual pulsed Doppler echocardiography.,
Journal of the American Society of Echocardiography, Vol.20, 594, 2007. Kenya Kusunose, Hirotsugu Yamada, T Chono, H Niki, T Nakajima, K Yamaguchi, K Koshiba, Tomohito Kawano, Takeshi Soeki, Tetsuzo Wakatsuki, K Aihara and Hiromu Nishitani :
Measurement of left atrial volume curve by advanced 2D tissue tracking technique: validation by contrast multidetector computed tomography.,
Journal of the American Society of Echocardiography, Vol.20, 603, 2007. Kenya Kusunose, Hirotsugu Yamada, T Niki, T Nakajima, K Yamaguchi, K Koshiba, Tomohito Kawano, Takeshi Soeki, Tetsuzo Wakatsuki and Susumu Ito :
Relationship Between the Ratio of Peak Early Diastolic Transmitral Flow and Mitral Annular Velocities and the Plasma B-Type Natriuretic Peptide (BNP) Concentration in Patients with Atrial Fibrillation: Assessment by Simultaneous Recording of Transmitral Flow and Mitral Annular Velocity.,
Journal of the American College of Cardiology, Vol.49, No.9, 137A, 2007. Hirotsugu Yamada, H Motonari, Y Fukuda, K Yamaguchi, K Koshiba, Tomohito Kawano, Takeshi Soeki and Tetsuzo Wakatsuki :
Effect of aging on left atrial myocardial strain evaluated by 2D tissue tracking during lower body positive pressure.,
Journal of the American Society of Echocardiography, Vol.19, 613, 2006. Hirotsugu Yamada, Y Fukuda, K Yamaguchi, K Koshiba, Tomohito Kawano, Takeshi Soeki and Tetsuzo Wakatsuki :
Differentiation of left atrial dysfunction by changes in transmitral flow velocities during lower body positive pressure.,
Journal of the American Society of Echocardiography, Vol.19, 613, 2006. Takeshi Soeki, Y Fukuda, K Koshiba, K Yamaguchi, Tomohito Kawano, Hirotsugu Yamada, Tetsuzo Wakatsuki, Masahiro Nomura, Kenji Kangawa and Susumu Ito :
Ghrelin Protects Myocardium Against Ischemia/Reperfusion Injury via Inhibiting Myocardial Apoptosis.,
Journal of the American College of Cardiology, Vol.47, No.4A, 308A, 2006. Tomotsugu Tabata, H Tanaka, E Kimura, K Harada, Tetsuzo Wakatsuki, T Yamamoto, A Saito, K Uehara, N Kageyama, Hirotsugu Yamada and T Oki :
Longitudinal Myocardial Displacement and Strain Rate in the Hypertrophied Heart Evaluated by Tissue Strain Imaging With Doppler Angle Correction and Tissue Tracking Technique.,
Journal of the American College of Cardiology, Vol.41, No.6, 455A, 2003.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0735-1097(03)82521-4
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1016/S0735-1097(03)82521-4

(DOI: 10.1016/S0735-1097(03)82521-4) H Tanaka, Tomotsugu Tabata, E Kimura, Tetsuzo Wakatsuki, T Yamamoto, A Saito, Hirotsugu Yamada and T Oki :
Temporal change in the left ventricular transmyocardial systolic velocity profile evaluated by color tissue Doppler imaging.,
Journal of the American Society of Echocardiography, Vol.15, 534, 2002. H Tanaka, Tomotsugu Tabata, E Kimura, Tetsuzo Wakatsuki, T Yamamoto, A Saito, Hirotsugu Yamada and T Oki :
Noninvasive assessment of myocardial ischemia and necrosis using a newly developed tissue Doppler myocardial velocity profile.,
Journal of the American Society of Echocardiography, Vol.15, 511, 2002. H Tanaka, Tomotsugu Tabata, E Kimura, Tetsuzo Wakatsuki, T Yamamoto, A Saito, Hirotsugu Yamada and T Oki :
Effect of angiotensin II receptor antagonist on left ventricular myocardial relaxation abnormality in hypertensive patients: evaluation using a newly developed myocardial velocity profile.,
Journal of the American Society of Echocardiography, Vol.15, 496, 2002. Tomotsugu Tabata, T Oki, H Tanaka, E Kimura, Tetsuzo Wakatsuki, T Yamamoto, A Saito and Hirotsugu Yamada :
Quantitative analysis of the left ventricular segmental contractility in the normal subjects using newly developed angle-corrected tissue strain imaging.,
Journal of the American Society of Echocardiography, Vol.15, 490, 2002. Tomotsugu Tabata, T Oki, H Tanaka, E Kimura, Tetsuzo Wakatsuki, T Yamamoto, A Saito and Hirotsugu Yamada :
Novel index for evaluating wall motion abnormality using newly developed angle-corrected tissue strain imaging.,
Journal of the American Society of Echocardiography, Vol.496, 15, 2002. E Kimura, Tomotsugu Tabata, H Tanaka, Tetsuzo Wakatsuki, T Yamamoto, A Saito, Hirotsugu Yamada and T Oki :
Determinants of the left ventricular myocar-dial contractility in patients with hypertension evaluated by echocardiography.,
Journal of the American Society of Echocardiography, Vol.15, 499, 2002. Tomotsugu Tabata, T Oki, H Tanaka, Y Onose, M Matsuoka, T Tada, T Yamamoto, Tetsuzo Wakatsuki and Hirotsugu Yamada :
Myocardial Characterization of Cardiac Amyloidosis Using Myocardial Velocity Profile: Comparison With Hypertensive Heart Disease.,
Circulation, Vol.104, II-756, 2001. Tomotsugu Tabata, T Oki, Y Onose, M Matsuoka, T Tada, T Yamamoto, Tetsuzo Wakatsuki and Hirotsugu Yamada :
Novel Strategy for Detecting Myocardial Viability by Evaluating Improvement of Early Diastolic Left Ventricular Asynchrony Using Dobutamine Stress Pulsed Tissue Doppler Imaging.,
Circulation, Vol.104, II-749, 2001. T Yamamoto, T Oki, Hirotsugu Yamada, H Tanaka, M Matsuoka, T Tada, Tetsuzo Wakatsuki and Tomotsugu Tabata :
Prognostic value of atrial systolic mitral annulus motion velocity in patients with dilated failing heart.,
Journal of the American Society of Echocardiography, Vol.14, 428, 2001. H Tanaka, T Oki, Hirotsugu Yamada, Tetsuzo Wakatsuki, Tomotsugu Tabata, R Kanda, Y Abe and T Nabatame :
Early Diastolic Transmural Myocardial Velocity Profile Evaluated by Tissue Doppler Imaging in Normal Subjects and Patients With Left Ventricular Hypertrophy.,
Journal of the American Society of Echocardiography, Vol.14, 469, 2001. Hirotsugu Yamada, T Oki, H Tanaka, Tetsuzo Wakatsuki, Tomotsugu Tabata, R Kanda, Y Abe and T Nabatame :
Accurate Measurement of Systolic Transmural Myocardial Velocity Profile Using Tissue Doppler Imaging in Normal Subjects And Patients with Hypertrophic Cardiomyopathy.,
Journal of the American Society of Echocardiography, Vol.14, 458, 2001. Hirotsugu Yamada, T Oki, H Tanaka, M Matsuoka, T Yamamoto, T Tada, Tetsuzo Wakatsuki and Tomotsugu Tabata :
The Role of Short And Long Axes Function for Determining Late Diastolic Left Ventricular Filling in Patients with Hypertension: Assessment by Pulsed Tissue Doppler Imaging.,
Journal of the American Society of Echocardiography, Vol.14, 480, 2001. Hirotsugu Yamada, T Oki, H Tanaka, M Matsuoka, T Yamamoto, T Tada, Tetsuzo Wakatsuki and Tomotsugu Tabata :
Potential Application of Tissue Doppler Imaging of the Left Ventricular Myocardium in Assessing Regional Diastolic Function in Patients with Hypertrophic cardiomyopathy: Comparison with 1231-b-Methy1 Iodopheny1 Pentadecanoic Acid Myocardial Scintigraphy.,
Journal of the American Society of Echocardiography, Vol.14, 456, 2001. Hirotsugu Yamada, T Oki, Y Onose, M Matsuoka, T Yamamoto, Tomotsugu Tabata and Tetsuzo Wakatsuki :
Ultrasonic myocardial characterization of cardiac amyloidosis using tissue Doppler imaging.,
Journal of the American Society of Echocardiography, Vol.13, 468, 2000. M Matsuoka, T Oki, Y Mishiro, Hirotsugu Yamada, Y Onose, Tetsuzo Wakatsuki and Tomotsugu Tabata :
Quantitative assessment of left ventricular myocardial viability using systolic mitral annular descent velocity: A study with dobutamine stress pulsed tissue Doppler imaging.,
Journal of the American College of Cardiology, Vol.35, 483A, 2000. Tomotsugu Tabata, T Oki, Hirotsugu Yamada, K Fukuda, M Abe, Y Onose, Tetsuzo Wakatsuki, H Fujinaga, K Sakabe, J Ikata, Akiyoshi Nishikado and A Iuchi :
Relationship between left atrial appendage function and plasma concentration of atrial natriuretic peptide.,
Circulation, Vol.96, A209, 1997. Tomotsugu Tabata, T Oki, Hirotsugu Yamada, M Abe, K Manabe, K Fukuda, Tetsuzo Wakatsuki, K Sakabe, A Iuchi and Susumu Ito :
Relationship between left atrial appendage function and plasma concentration of atrial natriuretic peptide.,
Eur Heart J, Vol.18, 328, 1997. T Oki, Tomotsugu Tabata, Hirotsugu Yamada, Tetsuzo Wakatsuki, H Shinohara, Akiyoshi Nishikado, A Iuchi, N Fukuda and Susumu Ito :
Clinical application of pulsed Doppler tissue imaging for assessing abnormal relaxation of the left ventricle.,
Circulation, Vol.94, I-565, 1996. Hirotsugu Yamada, T Oki, Tomotsugu Tabata, K Manabe, K Fukuda, M Abe, A Iuchi, Akiyoshi Nishikado, Tetsuzo Wakatsuki, K Sakabe, J Ikata and Susumu Ito :
Assessment of myocardial circumferential shortening of the left ventricular wall using pulsed Doppler tissue imaging.,
Circulation, Vol.94, I-132, 1996. T Oki, A Iuchi, Tomotsugu Tabata, Hirotsugu Yamada, Akiyoshi Nishikado, Tetsuzo Wakatsuki, H Shinohara, N Fukuda and Susumu Ito :
Non-invasive assessment of left ventricular relaxation by pulsed Doppler tissue imaging: comparison with cardiac catheterization.,
Euro Heart J, 1996. K Sakabe, Tetsuzo Wakatsuki, H Shinohara, Akiyoshi Nishikado, Hirotsugu Yamada, Tomotsugu Tabata, A Iuchi, T Oki and Susumu Ito :
Coronary flow velocity immediately after reperfusion reflects myocardial microcirculation in canine acute myocardial infarction models.,
Journal of the American College of Cardiology, Vol.27, 405A, 1996. Kenya Kusunose, Hirotsugu Yamada, Yoshihito Saijo, Susumu Nishio, Yukina Hirata, Takayuki Ise, Koji Yamaguchi, Daiju Fukuda, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Preload Stress Echocardiography for the Assessment of Heart Failure With Preserved Ejection Fraction,
JACC. Cardiovascular Imaging, Vol.15, No.2, 375-378, 2022.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jcmg.2021.09.005
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34656477; ● Summary page in Scopus @ Elsevier: 2-s2.0-85123584116

(DOI: 10.1016/j.jcmg.2021.09.005, PubMed: 34656477, Elsevier: Scopus)

総説・解説

若槻哲三 :
冠不全, 心筋虚血(1 冠不全の定義と分類，2 冠不全の心電図所見，3 冠不全心電図の成因(ST偏位の成因)，4 運動負荷心電図と判断基準，5 狭心症と心電図，6 ST変化を起こす諸病態〉,
徹底解説!心電図-基礎から臨床までー(森博愛,丸山徹編著), 87-98, 2015年10月. 山田博胤, 坂東美佳, 西尾進, 天野里江, 鳥居裕太, 山口浩司, 若槻哲三, 佐田政隆 :
超音波後方散乱信号を用いた頸動脈プラークの性状診断とその臨床応用,
Neurosonology, Vol.28, No.suppl-1, 94, 2015年5月. 伊勢孝之, 高木恵理, 岩瀬俊, 楠瀬賢也, 山口浩司, 八木秀介, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
心臓サルコイドーシス再燃に対してメトトレキサートの併用が有効であった1例,
日本内科学会雑誌, Vol.104, No.6, 1175-1179, 2015年.

(要約): 心臓サルコイドーシスの標準的治療はステロイドであるが，ステロイドを投与中であっても再燃を認めることも多く，またステロイドの多岐にわたる副作用も問題となることが多い．症例は70歳代，女性．心臓サルコイドーシスの診断でプレドニンを維持量5 mg/日で加療されていた．定期検査で施行した心電図で陰性T波，前壁心尖部に新規の左室壁運動異常を認めた．FDG-PET，Gaシンチグラフィーで壁運動異常部位に一致して集積を認め，心臓サルコイドーシスの再燃と判断した．本症例では，ステロイドの副作用として糖尿病，肥満，白内障などを認めており，ステロイド増量が躊躇され，メトトレキサートの併用を開始した．メトトレキサート開始後，特に副作用を認めず，心電図ならびに左室壁運動異常の改善が認められた．ステロイド投与で再燃を認める心臓サルコイドーシス症例にはメトトレキサート併用も考慮すべきであると考えられた．
(キーワード): 心臓サルコイドーシス / 再燃 / ステロイド (steroid) / メトトレキサート / 副作用
(出版サイトへのリンク): ● Publication site (DOI): 10.2169/naika.104.1175
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390001206449318272; ● Search Scopus @ Elsevier (DOI): 10.2169/naika.104.1175

(DOI: 10.2169/naika.104.1175, CiNii: 1390001206449318272) 今田久美子, 八木秀介, 山口浩司, 若槻哲三, 伊勢孝之, 太田理絵, 門田宗之, 高島啓, 松浦朋美, 飛梅威, 岩瀬俊, 山田博胤, 添木武, 赤池雅史, 佐田政隆 :
心不全を合併した腎血管性高血圧に対する経皮的腎動脈形成術の有効性(第11回若手奨励賞受賞論文),
四国医学雑誌, Vol.70, No.3, 4, 87-92, 2014年8月.

(要約): 【Background】 Percutaneous transluminal renal angioplasty (PTRA) is recommended for patients with heart failure due to renovascular hypertension ; however, the clinical characteristics of the patients and the effects of PTRA on heart failure and cardiorenal function have not been elucidated. 【Methods】 We retrospectively analyzed data for 4 PTRA-treated patients (male/female, 1/3 ; mean age, 70.0±10 years ; mean left ventricular ejection fraction, 51.5±15.2%) with heart failure due to renovascular hypertension and evaluated the effects of PTRA on heart failure and cardiorenal function 6 months after treatment. 【Results】 All patients had pro-arteriosclerotic diseases including diabetes mellitus, essential thrombocythemia, heparin cofactor II deficency, metabolic syndrome, and familial hypercholesterolemia, and 3 patients had ischemic heart disease. No abdominal bruit was heard and mean plasma renin activity was 4.5±3.6 ng/ml/hr, which was not elevated, contrary to expectation. All contralateral kidneys of PTRA were nonfunctioning, suggesting bilateral kidneys were disturbed in all patients. In all patients, PTRA was successfully performed and resolved heart failure. PTRA resulted in decreases in systolic blood pressure from 157±18 to 124±8.6 mmHg, mean serum creatinine from 3.2±2.6 to 2.7±2.2 mg/dl, and mean BNP from 919±998 to 243±291 pg/ml at 6 months after treatment. PTRA did not change left ventricular ejection fraction, a parameter of systolic fraction evaluated by an echocardiogram ; however, PTRA improved E/e', a parameter of left ventricular diastolic fraction, from 16.1±5.2 to 9.7±3.7. None of the patients were hospitalized due to heart failure during the 6-month period after PTRA. 【Conclusions】 Patients with heart failure with cardiovascular risk factors should be screened for renovascular hypertension regardless of abdominal bruit or plasma renin activity. PTRA is effective for resolving heart failure and for improving renal and cardiac diastolic functions in patients with renovascular hypertension complicated with heart failure.
(キーワード): 心不全 (heart failure) / cardiac disturbance syndrome / percutaneous transluminal renal angioplasty
(徳島大学機関リポジトリ): ● Metadata: 109759
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1010000782245831073

(徳島大学機関リポジトリ: 109759, CiNii: 1010000782245831073) 若槻哲三 :
≪疾患別循環器薬の使い方≫ 抗血小板薬,
臨床雑誌内科, Vol.112, No.3, 461-467, 2013年9月.

(要約): 虚血性心疾患に対する治療，とくに冠動脈インターベンション(PCI)との絡みにおいて抗血小板薬の重要性は広く認識されており，現在，わが国においてはアスピリン，クロピドグレルが大きな役割を担っている．薬剤溶出ステント(DES)は現在PCI治療の主流となっているが，このDES植え込み後の抗血小板薬2剤併用療法はステント血栓症予防の観点から重要であり，わが国におけるその至適投与方法・期間が明らかにされつつある．しかしながら，とくに投与期間に関しては，血栓予防と出血リスクのリスク-ベネフィットを個々の症例の状況で熟考する慎重さも必要である．高齢化に伴い抗凝固療法との併用の機会も増えており，わが国における至適併用療法の検討が望まれる．
(キーワード): 抗血小板薬 / アスピリン / クロピドグレル / 抗血小板薬2剤併用療法 / 薬剤溶出ステント

伊勢孝之, 若槻哲三 :
Adaptive Servo Ventilation (ASV) とは?,
人工呼吸, Vol.30, No.1, 28-35, 2013年5月. 若槻哲三 :
心筋梗塞の最新の治療について -発症の現場から急性期治療まで- (特集:心筋梗塞から身を守る -発作が起こる前と起こってからできること-),
四国医学雑誌, Vol.67, No.3-4, 123-126, 2011年8月.

(徳島大学機関リポジトリ): ● Metadata: 83823

(徳島大学機関リポジトリ: 83823) 若槻哲三, 斎藤彰浩 :
麻酔覚醒時に誘発されたたこつぼ型心筋障害,
日本臨床麻酔学会誌, Vol.23, No.7, 191-194, 2003年9月.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390282679737093632

(CiNii: 1390282679737093632) 若槻哲三, 大木崇 :
心臓弁膜症．僧帽弁閉鎖不全症の診断と治療, --- 臨床的特徴と内科治療の原則 ---,
臨床雑誌内科, Vol.87, 75-80, 2001年. 若槻哲三, 大木崇 :
主要疾患の最新の話題1999．虚血性心疾患,
Medicament News, Vol.1606, 10-12, 1999年. 若槻哲三, 大木崇 :
循環器疾患のエコー診断．無症候性心筋虚血の超音波診断をどのように行うか,
臨床医, Vol.24, 707-709, 1998年. 若槻哲三, 大木崇 :
患者のQOLを考慮した私の第一選択薬．収縮性心膜炎,
治療, Vol.80, 246-247, 1998年. 若槻哲三, 大木崇 :
処方―私の考え方―Brugada症候群,
臨床と研究, Vol.73, 1203-1204, 1996年. 若槻哲三, 大木崇 :
処方-私の考え方-Brugada症候群,
臨床と研究, Vol.73, 1203-1204, 1996年. 若槻哲三, 山口徹 :
冠動脈形成術後の再狭窄の対策,
臨床成人病, Vol.24, 1217-1222, 1994年. 若槻哲三, 山口徹 :
急性心筋梗塞に対する再灌流療法としての血栓溶解療法と経皮的冠動脈形成術(PTCA)の比較について,
血栓と循環, Vol.2, 120-122, 1994年. 若槻哲三, 山口徹 :
冠動脈硬化とPTCA,
循環科学, Vol.14, 138-142, 1994年.

講演・発表

Natsumi Yamaguchi, TOMONORI Takahashi, Susumu Nishio, Robert Zheng, Yoshihito Saijyo, Muneyuki Kadota, Yutaka Kawabata, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Hirotsugu Yamada, Tetsuzo Wakatsuki and Masataka Sata :
Elevated left atrial stiffness index is a poor prognostic factor in heart failure with preserved ejection fraction undergoing transcatheter aortic valve replacement,
EUROECHO 2024, Dec. 2024. TOMONORI TAKAHASHI, Tetsuzo Wakatsuki, Ryo Bando, Yoshihito Saijo, Yutaka Kawabata, Rie Ueno, Tomomi Matsuura, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Association of Elevated Lipoprotein(a) Levels with Adverse Outcomes in Patients with Stable Angina Undergoing Stent-less PCI with Paclitaxel-coated Balloon,
AHA 2024, Chicago, Nov. 2024. Tezuka Kazuki, Takeshi Soeki, Tomoko Takahashi, Tomomi Matsuura, Akihiro Tani, Ryo Bando, R Zheng, TOMONORI Takahashi, Yoshihito Saijo, Tomoya Hara, Muneyuki Kadota, Yutaka Kawabata, Rie Ueno, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Hirotsugu Yamada, Tetsuzo Wakatsuki and Masataka Sata :
Risk Factors For Intraoperative Instability In Sedated Patients Undergoing Pulmonary Vein Isolation Ablation,
Sydney, Sep. 2024. Tomoko Takahashi, Takeshi Soeki, Tezuka Kazuki, TOMONORI Takahashi, Yoshihito Saijo, Tomoya Hara, Yutaka Kawabata, Muneyuki Kadota, Rie Ueno, Tomomi Matsuura, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Hirotsugu Yamada, Tetsuzo Wakatsuki and Masataka Sata :
NAFLD score predicts the onset of atrial fibrillation,
APHRS 2024, Sydney, Sep. 2024. TOMONORI Takahashi, K Yamaji, S Kohsaka, H Ishii, Y Mori, Tetsuzo Wakatsuki, Koji Yamaguchi, D Nisioka, Kenya Kusunose, T Amano and Masataka Sata :
Drug-Coated Balloon versus Drug-Eluting Stent for DeNovo Culprit Lesion in Acute Coronary Syndromes: A Report from Nationwide Registry in Japan,
ESC 2024, London, Aug. 2024. Yoshihito Saijo, Hirotsugu Yamada, Robert Zheng, TOMONORI Takahashi, Yutaka Kawabata, Rie Ueno, Muneyuki Kadota, Tomoya Hara, Tomomi Matsuura, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Differential echocardiographic profiles in immunoglobulin light chain and transthyretin amyloid cardiomyopathy: insights from speckle tracking analysis,
ESC 2024, London, Aug. 2024. R Bando, Tetsuzo Wakatsuki, Koji Yamaguchi, TOMONORI Takahashi, Takayuki Ise, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Clinical outcome of DCB vs DES for de novo large coronary lesion in HBR patients,
Euro PCR 2024, Paris, May 2024. Kohei Nagano, TOMONORI Takahashi, Tetsuzo Wakatsuki, Robert Zheng, Yoshihito Saijyo, Muneyuki Kadota, Yutaka Kawabata, Tomomi Matsuura, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Long-Term Outcome of Stentless Coronary Intervention With Drug-Coated Balloon in Patients With High Bleeding Risk,
AHA2023, Philadelphia, Nov. 2023. N Yamaguchi, Kenya Kusunose, Yukina Hirata, Susumu Nishio, TOMONORI Takahashi, Yoshihito Saijo, Muneyuki Kadota, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Improved Pressure-Flow Relationship With Sacubitril/Valsartan: A 6-min Walk Stress Echocardiographic Study,
AHA2023, Philadelphia, Nov. 2023. TOMONORI Takahashi, Tetsuzo Wakatsuki, Kenya Kusunose, Takayuki Ise and Masataka Sata :
The aneurysm that vanished into thin air:Spontaneous thrombosis of a giant aneurysm complicated with the coronary to pulmonary artery fistula,
ESC2023, Amsterdam, Aug. 2023. Ryou Bando, Tetsuzo Wakatsuki, Koji Yamaguchi, Yutaka Kawabata, TOMONORI Takahashi, Yoshihito Saijyo, Muneyuki Kadota, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, S Yagi, Hirotsugu Yamada, T Soeki, M Akaike and Masataka Sata :
Two-year outcomes of drug-coated balloon only strategy for de novo lesions in large coronary vessels,
ESC2023, Amsterdam, Aug. 2023. Y Okushi, Kenya Kusunose, Hiromitsu Seno, TOMONORI Takahashi, Yoshihito Saijyo, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
The Impact of Surveillance of Cancer Therapeutics-Related Cardiac Dysfunction by Periodic Echocardiography,
ASE2022, Seattle, Jun. 2022. Koji Yamaguchi, Tetsuzo Wakatsuki, Y Okushi, Kumiko Suto, Kazuhisa Matsumoto, Tomonori Takahashi, Muneyuki Kadota, Yutaka Kawabata, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Early and chronic phased local coagulative responses following bioresorbable-polymer drug-eluting stent implantation,
European Heart Journal, Vol.42, No.S1, ehab724.1245, Aug. 2021.

(出版サイトへのリンク): ● Publication site (DOI): 10.1093/eurheartj/ehab724.1245
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1093/eurheartj/ehab724.1245

(DOI: 10.1093/eurheartj/ehab724.1245) Miharu Arase, Kenya Kusunose, Sae Morita, N Yamaguchi, Yukina Hirata, Susumu Nishio, Takayuki Ise, Koji Yamaguchi, Daiju Fukuda, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Clinical Utility of Noninvasive Assessment of Flow-pressure Relationship in Scleroderma,
American Heart Associeition, Dallas, Nov. 2020. Y Okushi, Kenya Kusunose, Takayuki Ise, Takeshi Tobiume, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Differences ofCancer Types in Hospital Mortality in Patients With Venous Thromboembolism,
American Heart Association, Dallas, Nov. 2020.

(出版サイトへのリンク): ● Publication site (DOI): 10.1161/circ.142.suppl_3.13145
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1161/circ.142.suppl_3.13145

(DOI: 10.1161/circ.142.suppl_3.13145) Koji Yamaguchi, Tetsuzo Wakatsuki, Tomonori Takahashi, Muneyuki Kadota, Yutaka Kawabata, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Takeshi Tobiume, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Suppressed Local Coagulative Response After Newer-generation Ultrathin Strut SES Implantation Compared to Older-generation SES Implantation,
American Heart Association, Dallas, Nov. 2020.

(出版サイトへのリンク): ● Publication site (DOI): 10.1161/circ.142.suppl_3.12894
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1161/circ.142.suppl_3.12894

(DOI: 10.1161/circ.142.suppl_3.12894) Takeshi Soeki, Kazuhisa Matsumoto, Daiju Fukuda, E Uematsu, Tomomi Matsuura, Takeshi Tobiume, Kenya Kusunose, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Hirotsugu Yamada, Tetsuzo Wakatsuki and Masataka Sata :
Toll-like receptor 9 is a novel therapeutic target to prevent atrial fibrillation,
European Heart Journal, Vol.41, No.S2, ehaa946.0463, Aug. 2020.

(出版サイトへのリンク): ● Publication site (DOI): 10.1093/ehjci/ehaa946.0463
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1093/ehjci/ehaa946.0463

(DOI: 10.1093/ehjci/ehaa946.0463) Tomonori Takahashi, Kenya Kusunose, Shuji Hayashi, Sae Morita, Yuta Torii, Yukina Hirata, M Yamao, Susumu Nishio, Yuichiroh Ohkushi, M Abe, Hirotsugu Yamada, Tetsuzo Wakatsuki and Masataka Sata :
Updated prevalence of lambls excrescences using the latest three-dimensional tansesophageal echocardiography,
Euro Echo 2019, Wien, Dec. 2019. Kenya Kusunose, Nishio Susumu, Hirata Yukina, Takayuki Ise, Koji Yamaguchi, Daiju Fukuda, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Pulmonary Artery Hypertension Specific Therapy Improves Exercise Tolerance and Outcomes in Exercise-Induced Pulmonary Hypertension,
JACC. Cardiovascular Imaging, Vol.12, No.12, 2576-2579, Dec. 2019.

(キーワード): Adult / Aged / Antihypertensive Agents / Arterial Pressure / Disease Progression / Echocardiography, Stress / Exercise / Exercise Tolerance / Female / Humans / Male / Middle Aged / Progression-Free Survival / Prospective Studies / Pulmonary Arterial Hypertension / Pulmonary Artery / Recovery of Function / Time Factors / Vasodilator Agents / Walk Test
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jcmg.2019.07.002
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31422131; ● Search Scopus @ Elsevier (PMID): 31422131; ● Search Scopus @ Elsevier (DOI): 10.1016/j.jcmg.2019.07.002

(DOI: 10.1016/j.jcmg.2019.07.002, PubMed: 31422131) Yukina Hirata, Masataka Sata, Kenya Kusunose, Hirotsugu Yamada, Yuta Torii, Susumu Nishio, nao Yamada, Koji Yamaguchi, Takeshi Soeki and Tetsuzo Wakatsuki :
Usefulness of echocardiographic epicardial adipose tissue thickness for predicting coronary artery disease regardless of body mass index,
AHA2019, Philadelphia, Nov. 2019. Takeshi Soeki, Kazuhisa Matsumoto, Daiju Fukuda, 植松悦子, Tomomi Matsuura, Takeshi Tobiume, Kenya Kusunose, Takayuki Ise, Koji Yamaguchi, Hirotsugu Yamada, Tetsuzo Wakatsuki and Masataka Sata :
Vildagliptin reduces inducitiligy of arterial fibrillation in hypertensive rats complicated with diabetes mellitus,
ESC Congress 2019, Paris, Sep. 2019. Koji Yamaguchi, Tetsuzo Wakatsuki, Rie Ueno, Yutaka Kawabata, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Takeshi Tobiume, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
The improvement of chronic local coagulative response according to the progress of drug eluting stent,
ESC Congress 2019, Paris, Sep. 2019. Maimaituxun Gulinu, Kenya Kusunose, Daiju Fukuda, Shusuke Yagi, Yuta Torii, Yukina Hirata, Susumu Nishio, nao Yamada, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Masataka Sata and Michio Shimabukuro :
Impact of epicardial adipose tissue on global longitudinal strain: a study in patients with normal left ventricular ejection fraction,
ESC Congress 2019, Paris, Sep. 2019. Maimaituxun Gulinu, Daiju Fukuda, Shusuke Yagi, Shoichiro Takao, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Masafumi Harada, Masataka Sata and Michio Shimabukuro :
Adipose tissue surrounding the kidney and its impact on coronary artery disease,
ESC Congress 2019, Paris, Sep. 2019. Y Saijo, Kenya Kusunose, Hirotsugu Yamada, Susumu Nishio, Yuta Torii, Y Hirata, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Right Ventricular Contractile Function Predicts Cardiac Events in Passive and Reactive Pulmonary Hypertension,
AHA, Chicago, Nov. 2018. Yukina Hirata, Kenya Kusunose, Hirotsugu Yamada, Susumu Nishio, O Harada, N Miyazato, A Haraguni, A Ito, Koji Yamaguchi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Epicardial Adipose Tissue Thickness Measured by Echocardiography is Useful Marker for Predicting Coronary Artery Disease,
AHA, Chicago, Nov. 2018. Takeshi Soeki, E Uematsu, Tomomi Matsuura, Takeshi Tobiume, Kenya Kusunose, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Tetsuzo Wakatsuki and Masataka Sata :
C-type natriuretic peptide improves left ventricular diastolic dysfunction and ischemia/reperfusion injury-associated ventricular arrhythmias.,
ESC2018, Munich, Aug. 2018. Hiroyuki Ito, Tetsuzo Wakatsuki, Koji Yamaguchi, Daiju Fukuda, Yutaka Kawabata, Takafumi Todoroki, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Takeshi Tobiume, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Growth of vasa vasorum is associated with local inflammation around coronary plaque in fresh cadavers,
ESC2018, Munich, Aug. 2018. Maimaituxun Gulinu, Michio Shimabukuro, Daiju Fukuda, Shusuke Yagi, Hirata Yukina, Takashi Iwase, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Takeshi Tobiume, Koji Yamaguchi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Gender disparities of distribution of epicardial adipose tissue and its impact on coronary artery disease,
ESC2018, Munich, Aug. 2018. Yukina Hirata, Kenya Kusunose, Hirotsugu Yamada, R Shimizu, Yuta Torii, Susumu Nishio, Y Okushi, Hiromitsu Seno, Y Saijo, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Quantitative Classification of Left Atrial Appendage is Superior to Visual Classification for Risk Stratification of Stroke in Atrial Fibrillation,
EACVI meeting 2018, Dec. 2017. Takeshi Soeki, Tomomi Matsuura, E Uematsu, Takeshi Tobiume, Kenya Kusunose, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Tetsuzo Wakatsuki and Masataka Sata :
Epicardial Adipose Tissue Produces Proinflammatory Cytokines and Influences the Pathogenesis of Atrial Fibrillation,
AHA Scientific Sessions2017, California, America, Nov. 2017. Yukina Hirata, Kenya Kusunose, Hirotsugu Yamada, J Kuwahata, Y Torii, S Nishio, H Seno, Y Saijo, Koji Yamaguchi, Tetsuzo Wakatsuki and Masataka Sata :
Detection of Coronary Artery Stenosis by Epicardial Adipose Tissue Thickness in Type 2 Diabetes,
AHA Scientific Sessions2017, California, America, Nov. 2017. Maimaituxun. Gulinu, Michio Shimabukuro, Y Hirata, Takashi Iwase, S Takao, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Takeshi Tobiume, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, M Harada and Masataka Sata :
Local Epicardial Adipose Tissue Thickness in Left Anterior Descending Artery Provides a New Prediction Model for Coronary Artery Disease,
AHA Scientific Sessions2017, California, America, Nov. 2017. Kenya Kusunose, Hirotsugu Yamada, S Nishio, Y Torii, Yukina Hirata, H Seno, Y Saijo, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Echocardiography Predicts Outcomes in Patients With Preserved Ejection Fraction and Low Gradient Aortic Stenosis,
AHA Scientific Sessions2017, California, America, Nov. 2017. Takeshi Soeki, Tomomi Matsuura, Daiju Fukuda, Etsuko Uematsu, Takeshi Tobiume, T Hara, Kenya Kusunose, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Hirotsugu Yamada, Tetsuzo Wakatsuki and Masataka Sata :
Activated Factor X Signaling Pathway via Protease-Activated Receptor-2 is a Novel Therapeutic Target to Prevent Atrial Fibrillation,
AHA Scientific Sessions2017, California, America, Nov. 2017. Koji Yamaguchi, Tetsuzo Wakatsuki, Yutaka Kawabata, H Ito, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Takeshi Tobiume, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Preserved Endothelial Function and Suppressed Local Coagulative and Inflammatory Response After Biodegradable Polymer SES Implantation Compared to Durable Polymer SES,
AHA Scientific Sessions2017, California, America, Nov. 2017. Tomomi Matsuura, Takeshi Tobiume, Takeshi Soeki, R Kato, M Hara, Kenya Kusunose, Koji Yamaguchi, Shusuke Yagi, Hirotsugu Yamada, Tetsuzo Wakatsuki and Masataka Sata :
Direct Slow Pathway Capture: A New Electrophysiological Method of Catheter Ablation for Atrioventricular Nodal Reentrant Tachycardia,
AHA Scientific Sessions2017, California, America, Nov. 2017. Susumu Nishio, Kenya Kusunose, Hirotsugu Yamada, Yukina Hirata, H Seno, Y Saijo, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Echocardiographic Epicardial Adipose Tissue Thickness is a Marker for the Detection of Vasospastic Angina,
ASE2017, Baltimore, Jun. 2017. Kenya Kusunose, Hirotsugu Yamada, Susumu Nishio, Y Hirata, Hiromitsu Seno, Y Saijo, Takayuki Ise, Koji Yamaguchi, Shuusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Right Ventricular Myocardial Strain during Preload Augmentation is Associated with Exercise Capacity,
ASE2017, Baltimore, Jun. 2017. Yukina Hirata, Hirotsugu Yamada, Kenya Kusunose, R Shimizu, Yuta Torii, Susumu Nishio, Hiromitsu Seno, Y Saijo, S Hayashi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Impact of Age on the Morphology of Left Atrial Appendage I Atrial Fibrillation,
AHA Scientific Sessions 2016, New Orleans, Nov. 2016. Kenya Kusunose, Hirotsugu Yamada, Y Saijo, H Seno, Y Hirata, Y Torii, S Nishio, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Longitudinal Strain Distribution is a Powerful Predictor for Functional Recovery in Patients With Tachycardia-induced Cardiomyopathy,
AHA Scientific Sessions 2016, New Orleans, Nov. 2016. Kenya Kusunose, Hirotsugu Yamada, H Seno, Y Saijo, Takayuki Ise, Takeshi Tobiume, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Longitudinal Strain Distribution is a Powerful Predictor for Functional Recovery in Patients with Tachycardia-induced Cardiomyopathy,
KSC2016(The 60th Annual Scientific Meeting of The Korean Society of Cardiology), Seoul, Sep. 2016. Takeshi Soeki, Tomomi Matsuura, E Uematsu, S Bando, Takeshi Tobiume, Kenya Kusunose, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Increased local production of C-type natriuretic peptide in patients with vasospastic angina,
ESC Congress 2016, Rome, Aug. 2016. Koji Yamaguchi, Tetsuzo Wakatsuki, R Ueno, H Ito, Takayuki Ise, Tomomi Matsuura, Kenya Kusunose, Takeshi Tobiume, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Paclitaxel eluting balloon angioplasty equals everolimus eluting stent implantation in local coagulative and inflammatory responses in stable angina patients,
ESC Congress 2016, Rome, Aug. 2016. T Matsuura, Takeshi Soeki, E Uematsu, S Bando, Takeshi Tobiume, T Hara, Kenya Kusunose, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Oral Direct Factor Xa Inhibitor Prevents Atrial Fibrillation by Inhibiting Inflammation in Rapidly Paced Spontaneously Hypertensive Rats,
ESC Congress 2016, Rome, Aug. 2016. H Seno, Kenya Kusunose, Hirotsugu Yamada, Y Saijo, S Nishio, Y Hirata, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Comparison of Right Ventricular Global Longitudinal Strain Between Vender-Dependent and Vender-Independent Two-Dimensional Speckle Tracking Software,
ACC Scientific Sessions 2016, Chicago, Apr. 2016. S Bando, Takeshi Soeki, Tomomi Matsuura, Takeshi Tobiume, Takayuki Ise, Kenya Kusunose, Koji Yamaguchi, Shusuke Yagi, Hirotsugu Yamada, Tetsuzo Wakatsuki and Masataka Sata :
Atrial Late Potentials and Atrial Substrate Remodeling in Patients With Atrial Fibrillation.,
AHA Scientific Sessions 2015, Orlando, Nov. 2015. Y Hirata, Hirotsugu Yamada, Kenya Kusunose, S Nishio, Mika Bando, Koji Yamaguchi, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Clinical Utility of Echocardiographic Epicardial Adipose Tissue Thickness Measured Using a High-frequency Linear Probe in Patients with Coronary Artery Disease.,
AHA Scientific Sessions 2015, Orlando, Nov. 2015. Takeshi Soeki, S Bando, Tomomi Matsuura, Takeshi Tobiume, E Uematsu, Kenya Kusunose, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Combination Of Clinical, Electrocardiographic and Echocardiographic Parameters Predict the Onset of Atrial Fibrillation.,
AHA Scientific Sessions 2015, Orlando, Nov. 2015. A Takashima, Daiju Fukuda, K Tanaka, Y Higashikuni, Y Hirata, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
N-3 Polyunsaturated Fatty Acids Inhibit Inflammatory Responses in Macrophages by the Reduction of Toll-like Receptor 4 Expression in Lipid Rafts, Leading to the Suppression of Atherogenesis in Apolipoprotein E Deficient Mice.,
AHA Scientific Sessions 2015, Orlando, Nov. 2015. T Hara, Daiju Fukuda, K Tanaka, Y Higashikuni, Y Hirata, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Hematopoietic Protease-activated Receptor-2 Plays a Critical Role in Vascular Inflammation and Atherosclerosis in ApoE-Deficient Mice.,
AHA Scientific Sessions 2015, Orlando, Nov. 2015. Kenya Kusunose, Hirotsugu Yamada, Mika Bando, S Nishio, Y Hirata, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Pressure-flow Relationship of Pulmonary Circulation Determines Six-minute Walk Distance in Connective Tissue Disease.,
AHA Scientific Sessions 2015, Orlando, Nov. 2015. Koji Yamaguchi, Tetsuzo Wakatsuki, A Takashima, Mika Bando, S Bando, Tomomi Matsuura, Takayuki Ise, Junko Hotsuchi, Takeshi Tobiume, Shusuke Yagi, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Differential response of local coagulation after implantation of new generation drug-eluting stents compared with sirolimus-eluting stent.,
AHA Scientific Sessions 2014, Chicago, Nov. 2014. T Hara, D Fukuda, K Tanaka, Y Higashikuni, Y Hirata, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Rivaroxaban, a direct factor Xa inhibitor, attenuates neointima formation after mechanical vascular injury.,
AHA Scientific Sessions 2014, Chicago, Nov. 2014. H Yamazaki, Tetsuzo Wakatsuki, Koji Yamaguchi, K Imada, K Matsumoto, Y Takagawa, E Takagi, Y Saijo, T Hara, Y Saito, Mika Bando, A Takashima, S Bando, Tomomi Matsuura, Takayuki Ise, Junko Hotsuchi, Takeshi Tobiume, Shusuke Yagi, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Differential responses of local coagulation after implantation of second-generation drug-eluting stent compared with first-generation drug-eluting stents.,
AHA Scientific Sessions 2014, Chicago, Nov. 2014. Tomomi Matsuura, Takeshi Soeki, E Uematsu, S Bando, Takeshi Tobiume, Daiju Fukuda, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
A renin inhibitor prevents atrial endocardial dysfunction in rapidly paced rats with streptozotocin-induced diabetes.,
ESC 2014, Barcelona, Aug. 2014. Takeshi Soeki, E Uematsu, S Bando, Tomomi Matsuura, Takeshi Tobiume, Daiju Fukuda, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Relationship between local production of microRNA-328 and atrial substrate remodeling in atrial fibrillation.,
ESC 2014, Barcelona, Aug. 2014. S Bando, Takeshi Soeki, Takeshi Tobiume, Tomomi Matsuura, E Uematsu, Daiju Fukuda, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Atrial late potentials and atrial substrate remodeling in patients with atrial fibrillation.,
ESC 2014, Barcelona, Aug. 2014. T Hara, Daiju Fukuda, K Tanaka, Y Higashikuni, Y Hirata, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, M Shimabukuro and Masataka Sata :
Rivaroxaban, a direct factor Xa inhibitor, attenuates neointima formation following vascular injury in the mouse through the inhibition of proliferative activation of vascular smooth muscle cells.,
ESC 2014, Barcelona, Aug. 2014. T Hara, Daiju Fukuda, K Tanaka, Y Higashikuni, Y Hirata, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, M Shimabukuro and Masataka Sata :
Rivaroxaban, a direct factor Xa inhibitor, attenuates plaque progression and destabilization in ApoE-deficient mice by inhibiting macrophage activation.,
ESC 2014, Barcelona, Aug. 2014. Junko Hotsuchi, Hirotsugu Yamada, Y Saijo, Mika Bando, S Hayashi, S Nishio, M Yamano, Y Torii, Y Hirata, R Amano, Takayuki Ise, Koji Yamaguchi, Takeshi Tobiume, Shusuke Yagi, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Serial Changes of Exercise Stress Echocardiographic Parameters in Patients with Connective Tissue Disease without Overt Pulmonary Hypertension.,
ASE 2014, Portland, Jun. 2014. Mika Bando, Hirotsugu Yamada, S Nishio, R Amano, Y Hirata, Junko Hotsuchi, Y Saijo, Koji Yamaguchi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Predicting Restenosis of Coronary Artery Stents by Ultrasound Tissue Characteristics of Carotid Artery Plaque.,
ASE 2014, Portland, Jun. 2014. Y Saijo, Hirotsugu Yamada, Junko Hotsuchi, S Nishio, S Hayashi, Mika Bando, Y Hirata, R Amano, Takayuki Ise, Shusuke Yagi, Koji Yamaguchi, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Right ventricular systolic dysfunction in patients with exercise-induced pulmonary hypertension associated with connective tissue disease.,
ACC 2014, Washington, D.C., Mar. 2014. Junko Hotsuchi, Hirotsugu Yamada, S Nishio, Mika Bando, S Hayashi, Y Hirata, R Amano, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Right ventricular dysfunction in patients with exercise-induced pulmonary hypertension associated with connective tissue disease : an assessment using tricuspid annular motion velocities.,
Euro Echo Imaging 2013, Istanbul, Dec. 2013. S Hayashi, Hirotsugu Yamada, Junko Hotsuchi, Mika Bando, Takayuki Ise, Koji Yamaguchi, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Noninvasively Obtained Augmentation Index is Not a Reliable Maker for Vascular Sclerosis in Elderly Subjects.,
American Heart Association AHA 2013, Dallas, Nov. 2013. T Hara, Daiju Fukuda, K Tanaka, Y Higashikuni, Y Hirata, Takayuki Ise, Takeshi Tobiume, Koji Yamaguchi, Shusuke Yagi, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Rivaroxaban, A Novel Oral Anticoagulant, Attenuates Plaque Progression in ApoE-Deficient Mice Through the Inhibition of Pro-Inflammatory Activation of Macrophages.,
American Heart Association AHA 2013, Dallas, Nov. 2013. Koji Yamaguchi, Takeshi Soeki, Tetsuzo Wakatsuki, Takayuki Ise, Takeshi Tobiume, Shusuke Yagi, Takashi Iwase, Hirotsugu Yamada and Masataka Sata :
Impact Of Indoxy1 Sulfate, A Uremic Toxin, On Non-culprit Coronary Plaque Composition Assessed By Integrated Backscatter Intravascular Ultrasound In Patients With Coronary Artery Disease.,
American Heart Association AHA 2013, Dallas, Nov. 2013. Koji Yamaguchi, Tetsuzo Wakatsuki, Takayuki Ise, Takeshi Tobiume, Shusuke Yagi, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Decreased Local Hypercoagulation after Implantation of Everolimus-Eluting and Zotarolimus-Eluting Stents Compared with Early-Generation Drug-Eluting Stents in patients with stable angina.,
American Heart Association AHA 2013, Dallas, Nov. 2013. Koji Yamaguchi, Tetsuzo Wakatsuki, Takayuki Ise, Takeshi Tobiume, Shusuke Yagi, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Time-dependent Changes Of Local Vascular Response And Angiographic Peri-stent Contrast Staining Up To Five Years After Zotarolimus-eluting, Sirolimus-eluting, And Bare Metal Stent Implantation.,
American Heart Association AHA 2013, Dallas, Nov. 2013. S Bando, Takeshi Soeki, T Matsuura, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro, Kenji Kangawa and Masataka Sata :
Plasma Brain Natriuretic Peptide (BNP) level is elevated in patients with cancer.,
ESC Congress 2013, Amsterdam, Aug. 2013. S Bando, Takeshi Soeki, E Uematsu, T Matsuura, Daiju Fukuda, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro, Kenji Kangawa and Masataka Sata :
Ghrelin ameliorates the progression of experimental autoimmune myocarditis.,
ESC Congress 2013, Amsterdam, Aug. 2013. Takeshi Soeki, S Bando, T Matsuura, E Uenmatsu, Koji Yamaguchi, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Electrophysiological correlation and prognostic impact of pentraxin 3 as a local inflammatory marker in atrial fibrillation.,
ESC Congress 2013, Amsterdam, Aug. 2013. Tetsuzo Wakatsuki, Koji Yamaguchi, Toshiyuki Niki, Yoshio Taketani, Takayuki Ise, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
The tissue characteristics of coronary plaque with microchannel structure assessed by optical coherence tomography associated with local inflammatory response.,
ESC Congress 2013, Amsterdam, Aug. 2013. Koji Yamaguchi, Tetsuzo Wakatsuki, Toshiyuki Niki, Yoshio Taketani, Takayuki Ise, Shusuke Yagi, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Differential responses of local coagulation after implantation of everolimus-eluting and zotarolimus-eluting stents compared with early-generation drug-eluting stents in patients with stable angina.,
ESC Congress 2013, Amsterdam, Aug. 2013. Takeshi Soeki, K Yamaguchi, S Bando, T Matsuura, E Uematsu, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Cardiospecific microRNA plasma levels are associated with coronary plaque vulnerability.,
ESC Congress 2013, Amsterdam, Aug. 2013. Y Hirata, Hirotsugu Yamada, S Nishio, Mika Bando, S Hayashi, Junko Hotsuchi, T Tomofuji, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Echocardiographic epicardial adipose tissue thickness in anterior interventricular groove is a marker for the presence and severity of coronary artery disease.,
ESC Congress 2013, Amsterdam, Aug. 2013. S Hayashi, Hirotsugu Yamada, S Nishio, N Tomita, J Hotchi, Mika Bando, Takayuki Ise, Toshiyuki Niki, Koji Yamaguchi, Shusuke Yagi, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Augmentation Index Measured by Tonometry Significantly Underestimates Atrial Stiffness in Ischemic Heart Disease in Japanese Population.,
第77回日本循環器学会学術集会, Yokohama, Mar. 2013. Mika Bando, Hirotsugu Yamada, Toshiyuki Niki, S Nishio, R Tamai, J Hotchi, Yoshio Taketani, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Change in Ultrasonic Tissue Characteristics of Carotid Artery Plaque Reflects That of Coronary Artery Plaque.,
American College of Cardiology (ACC) 2013 Scientific Sessions, San Francisco, Mar. 2013. Takayuki Ise, Shusuke Yagi, Takashi Iwase, Masashi Akaike, M Kadota, T Hara, S Bando, Toshiyuki Niki, J Hotchi, N Tomita, Koji Yamaguchi, Yoshio Taketani, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Acute Hemodynamic Effects of Adaptive Servo-Ventilation in Patients with Chronic Left Heart Failure.,
AHA Scientific Sessions 2012, ロサンゼルス, Nov. 2012. Koji Yamaguchi, Tetsuzo Wakatsuki, Takeshi Soeki, Toshiyuki Niki, Yoshio Taketani, H. Oeduka, Mika Bando, K. Ogasawara, S. Bando, J. Hotchi, Takayuki Ise, Takashi Iwase, Hirotsugu Yamada and Masataka Sata :
Telmisartan Reduces Coronary Plaque Vulnerability and Instent-neointimal Proliferation in Hypertensive Patients.,
AHA Scientific Sessions 2012, ロサンゼルス, Nov. 2012. Toshiyuki Niki, Tetsuzo Wakatsuki, Mika Bando, K. Ogasawara, S. Bando, T. Matsuura, J. Hotch, Koji Yamaguchi, Yoshio Taketani, Takashi Iwase, N. Tomita, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Effects of Additional Eicosapentaenoic Acid to Statin Therapy on Inflammatory Cytokines and the Tissue Characterization of Coronary Plaque Assessed by Integrated Backscatter Intravascular Ultrasound Systems.,
AHA Scientific Sessions 2012, Nov. 2012. A. Takashima, Takayuki Ise, Masashi Akaike, Yuka Ueda, Takashi Iwase, T. Hara, M. Kadota, R. Ohta, K. Ogasawara, Toshiyuki Niki, J. Hotchi, Koji Yamaguchi, Yoshio Taketani, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Cardiac Rehabilitation Reduces Levels of Oxidized LDL.,
AHA Scientific Sessions 2012, ロサンゼルス, Nov. 2012. S. Bando, Takeshi Soeki, E. Uematsu, T. Matsuura, M. Kadota, T. Hara, R. Ohta, Y. Kawabata, K. Ogasawara, Mika Bando, Toshiyuki Niki, Takayuki Ise, J. Hotchi, N. Tomita, Yuka Ueda, Koji Yamaguchi, Yoshio Taketani, Takashi Iwase, Daiju Fukuda, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Relationship Between Nlrp3 Inflammasome and Coronary Atherosclerosis.,
AHA Scientific Sessions 2012, ロサンゼルス, Nov. 2012. S. Kimura, Yuka Ueda, Takayuki Ise, Takashi Iwase, K. Maeda, K. Nishikawa, K. Ogasawara, Mika Bando, S. Bando, Toshiyuki Niki, J. Hotchi, Koji Yamaguchi, N. Tomita, Yoshio Taketani, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Effect of Cardiac Rehabilitation with Supervised Exercise Training on Urinary Albumin Excretion in Patients with Cardiovascular Disease.,
AHA Scientific Sessions 2012, ロサンゼルス, Nov. 2012. Takeshi Soeki, S. Bando, Toshiyuki Niki, Koji Yamaguchi, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Kenji Kangawa and Masataka Sata :
Ghrelin protects the heart against ischemia-induced arrhythmias by modulating autonomic nerve activity.,
ESC Congress 2012, Munich, Aug. 2012. Takeshi Soeki, M. Kitani, Hirotsugu Yamada, Tetsuzo Wakatsuki, T. Kawano, S. Orino, K. Kawano, A. Kakutani, S. Bando and Masataka Sata :
Renoprotective effect of cilnidipine via the antioxidant activity in hypertensive patients.,
ESC Congress 2012, Munich, Aug. 2012. Toshiyuki Niki, Tetsuzo Wakatsuki, Koji Yamaguchi, Yoshio Taketani, S Bando, Takayuki Ise, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
The tissue characteristics of coronary plaque with microchannel structure in patients with Coronary Artery Disease assessed by OCT and IB-IVUS.,
ESC Congress 2012, Munich, Aug. 2012. Mika Bando, Hirotsugu Yamada, N Tomita, S. Nishio, R. Tamai, S. Hayashi, J. Hotchi, Takayuki Ise, Toshiyuki Niki, Koji Yamaguchi, Takashi Iwase, Yoshio Taketani, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Left Ventricular Geometry and Function in Patients with Sigmoid Septum.,
American Society of Echocardiography (ASE) 23rd Annual Scientific Sessions, Maryland, Jun. 2012. S Hayashi, Hirotsugu Yamada, N Tomita, J Hotchi, Mika Bando, S Nishio, R Tamai, M Nakagawa, Takayuki Ise, Toshiyuki Niki, Koji Yamaguchi, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Differentiation Between Hypertrophic Cardiomyopathy and Hypertensive Heart Disease Using Tricuspid Annular Motion Velocity.,
American Society of Echocardiography (ASE) 23rd Annual Scientific Sessions, Maryland, Jun. 2012. Mika Bando, Hirotsugu Yamada, S Nishio, R Tamai, N. Tomita, S. Hayashi, J. Hotchi, M. Nakagawa, D. Hirota, Y. Hirata, S. Bando, Takayuki Ise, Toshiyuki Niki, Koji Yamaguchi, Takashi Iwase, Yoshio Taketani, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Effect of Statin Therapy on Regression of Carotid Artery Plaque Assessed by High-Resolution Color Mapping Method Based on Integrated Backscatter.,
American Society of Echocardiography (ASE) 23rd Annual Scientific Sessions, Maryland, Jun. 2012. J. Hotchi, Hirotsugu Yamada, S Nishio, Kenya Kusunose, N Tomita, S Hayashi, Mika Bando, R Tamai, M Nakagawa, D Hirota, Y Hirata, K Ogasawara, S Bando, Takayuki Ise, Toshiyuki Niki, Koji Yamaguchi, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Efficacy of Six-minute Walk Stress Echocardiography for Detection of Pulmonary Arterial Hypertension in Patients With Connective Tissue Disease.,
American Society of Echocardiography (ASE) 23rd Annual Scientific Sessions, Maryland, Jun. 2012. J. Hotchi, Hirotsugu Yamada, R. Tamai, S. Nishio, N. Tomita, S. Hayashi, Mika Bando, S. Bando, Takayuki Ise, Toshiyuki Niki, Koji Yamaguchi, Takashi Iwase, Yoshio Taketani, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Assessment of Tricuspid Annular Motion Velocities in Pulmonary Hypertension of Various Etiologies.,
American Society of Echocardiography (ASE) 23rd Annual Scientific Sessions, Maryland, Jun. 2012. Kenya Kusunose, Hirotsugu Yamada, S. Nishio, N. Tomita, S. Hayashi, J. Hotchi, R. Tamai, D. Hirota, Y. Hirata, Mika Bando, K. Ogasawara, A. Takashima, H. Yamazaki, S. Bando, Takayuki Ise, Toshiyuki Niki, Koji Yamaguchi, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Single-Beat Assessment of Left Ventricular Systolic and Diastolic Function during Atrial Fibrillation using Myocardial Strain and Strain Rate.,
AHA Scientific Sessions 2011, Orlando, Nov. 2011. Takeshi Soeki, S. Bando, Toshiyuki Niki, H. Yamazaki, A. Takashima, K. Ogasawara, Mika Bando, Takayuki Ise, H. Takeuchi, N. Tomita, Yuka Ueda, Kenya Kusunose, Koji Yamaguchi, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki and Masataka Sata :
Pentraxin 3 is a Local Inflammatory Maker in Atrial Fibrillation.,
AHA Scientific Sessions 2011, Orlando, Nov. 2011. Mika Bando, Hirotsugu Yamada, S. Nishio, E. Uematsu, S. Hayashi, J. Hotchi, Kenya Kusunose, N. Tomita, R. Tamai, Y. Hirata, D. Hirota, M. Nakagawa, Toshiyuki Niki, Koji Yamaguchi, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Ultrasonic Tissue Characterization of Carotid Artery Plaque using High-resolution Integrated Backscatter Imaging;Validation Study with Histological Correlation.,
AHA Scientific Sessions 2011, Orlando, Nov. 2011. Koji Yamaguchi, Tetsuzo Wakatsuki, Takeshi Soeki, Toshiyuki Niki, Yoshio Taketani, H. Oezuka, S. Bando, N. Tomita, Kenya Kusunose, Takashi Iwase, Hirotsugu Yamada and Masataka Sata :
Effects of Telmisartan on Inflammatory Cytokines and Coronary Plaque Component Assessed by Integrated Backscatter Intravascular Ultrasound in Hypertensive Patients.,
AHA Scientific Sessions 2011, Orlando, Nov. 2011. Takashi Iwase, Shoichiro Takao, Masashi Akaike, Takayuki Ise, Toshiyuki Niki, Kenya Kusunose, Yuka Ueda, N. Tomita, Koji Yamaguchi, Yoshio Taketani, Hirotsugu Yamada, Takeshi Soeki, Ken-ichi Aihara, Tetsuzo Wakatsuki, Masafumi Harada and Masataka Sata :
Detection of Cardiac Involvement in Patients with Sarcoidosis Using Cardiac Magnetic Resonance.,
AHA Scientific Sessions 2011, Orlando, Nov. 2011. S. Nishio, Hirotsugu Yamada, R. Tamai, K. Endo, S. Hayashi, Kenya Kusunose, Takeshi Soeki, Tetsuzo Wakatsuki, Y. Sakai and Masataka Sata :
Deterioration of right ventricular myocardial systolic function in monocrotaline-induced pulmonary arterial hypertension canine model: echocardiographic evaluation by 2D speckle tracking.,
ESC Congress 2011, Paris, Aug. 2011. Koji Yamaguchi, Tetsuzo Wakatsuki, Toshiyuki Niki, Yoshio Taketani, S. Bando, Kenya Kusunose, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Differential response of local persistent hypercoagulability after zotarolimus-eluting, paclitaxel-eluting, sirolimus-eluting and bare-metal stent implantation in patients with stable angina.,
ESC Congress 2011, Paris, Aug. 2011. Koji Yamaguchi, Tetsuzo Wakatsuki, Toshiyuki Niki, Yoshio Taketani, S. Bando, Kenya Kusunose, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Time-dependent changes of local coagulative response up to five years after sirolimus-eluting and bare-metal stent implantation in patients with stable angina.,
ESC Congress 2011, Paris, Aug. 2011. Takeshi Soeki, S. Bando, Toshiyuki Niki, Kenya Kusunose, Koji Yamaguchi, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki and Masataka Sata :
Elevated concentration of pentraxin 3 is associated with local inflammation in atrial fibrillation.,
ESC Congress 2011, Paris, Aug. 2011. Tetsuzo Wakatsuki, Toshiyuki Niki, Koji Yamaguchi, Yoshio Taketani, Takashi Iwase, Kenya Kusunose, S. Bando, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Long-term local inflammatory and coagulative responses after coronary artery stenting with drug-eluting stent.,
ESC Congress 2011, Paris, Aug. 2011. R. Tamai, Hirotsugu Yamada, S. Nishio, Kenya Kusunose, N. Tomita, S. Hayashi, M. Sato, H. Hiraoka, J. Miki, Toshiyuki Niki, Koji Yamaguchi, Takashi Iwase, Yoshio Taketani, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Comparison of Tricuspid Annular Motion Velocities in Patients with Pulmonary Arteril Hypertension Secondary to Heart Failure.,
American Society of Echocardiography 2011. 22st Annual Scientific Sessions. Montreal, Montreal, Jun. 2011. 楠瀬賢也, 山田博胤, 西尾進, 冨田紀子, 林修司, 玉井利奈, 坂東左知子, 久岡白陽花, 仁木敏之, 上田由佳, 山口浩司, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
ストレインイメージング法を用いた心房細動例の左室心筋機能評価―左室圧曲線との同時記録による検討―,
第98回日本循環器学会中国・四国合同地方会, 徳島, 2011年5月. S Nishio, Hirotsugu Yamada, R Tamai, K Endo, S Hayashi, Kenya Kusunose, N Tomita, J Miki, S Bando, S Hisaoka, Toshiyuki Niki, Koji Yamaguchi, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Relationship Between Carotid Artery Stiffness Parameter β and Brachial Artery Flow-mediated Dilation in coronary Artery Disease.,
American College of Cardiology 2011, New Orleans, Apr. 2011. Koji Yamaguchi, Tetsuzo Wakatsuki, Toshiyuki Niki, Yoshio Taketani, S. Bando, S. Hisaoka, Kenya Kusunose, Yuka Ueda, H. Takeuchi, Takashi Iwase, N. Tomita, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Time-dependent Changes Of Local Coagulative Response Up To Five Years After Sirolimus-eluting Stent Implantation.,
American Heart Association 2010, Chicago, Nov. 2010. Tetsuzo Wakatsuki, Koji Yamaguchi, Toshiyuki Niki, Kenya Kusunose, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Long-Term Local Inflammatory and Coagulative Responses after Coronary Artery Stenting with Drug-Eluting Stent.,
American Heart Association 2010, Chicago, Nov. 2010. Kenya Kusunose, Hirotsugu Yamada, S. Nishio, N. Tomita, S. Hayashi, S. Bando, S. Hisaoka, Toshiyuki Niki, Koji Yamaguchi, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Left Ventricular Dyssynchrony during Lower Leg Positive Pressure Assessed by Real-time 3-dimensional Echocardiography.,
American Heart Association 2010, Chicago, Nov. 2010. Takeshi Soeki, Toshiyuki Niki, S. Bando, S. Hisaoka, H. Takeuchi, Kenya Kusunose, Koji Yamaguchi, Y. Hirata, N. Tomita, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Masashi Akaike, K. Kangawa and Masataka Sata :
Ghrelin Protects Heart Against Ischemia-Induced Arrhythmias by Preserving Connexin43 Protein.,
American Heart Association 2010, Chicago, Nov. 2010. Kenya Kusunose, Hirotsugu Yamada, S. Nishio, N. Tomita, S. Hayashi, S. Bando, S. Hisaoka, Toshiyuki Niki, Koji Yamaguchi, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Time Difference between Onset of Mitral Inflow and Onset of Early Diastolic Mitral Annulus Velocity Predicts Left Ventricular End-diastolic Pressure: Assessment by Dual Doppler Echocardiography.,
American Heart Association 2010, Chicago, Nov. 2010. Takeshi Soeki, Toshiyuki Niki, S. Bando, S. Hisaoka, H. Takeuchi, Kenya Kusunose, Koji Yamaguchi, Y. Hirata, N. Tomita, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Masashi Akaike, K. Kangawa and Masataka Sata :
Ghrelin Attenuates Myocardial Ischemia/Reperfusion Injury via the Extracellular Signal-Regulated Kinase 1/2 and Phosphatidylinositol 3-Kinase/Akt Pathway.,
American Heart Association 2010, Chicago, Nov. 2010. Toshiyuki Niki, Tetsuzo Wakatsuki, Koji Yamaguchi, Kenya Kusunose, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Impact of Statin Theraphy on Local Coagulative Response after sirolimus-eluting Stent Implantation in late chronic Phase.,
ESC CONGRESS 2010, Stockholm, Aug. 2010. Kenya Kusunose, Hirotsugu Yamada, S Nishio, N Tomita, K Endo, H Takashima, C Mimura, M Yamanaka, J Miki, T Niki, Koji Yamaguchi, Kunihiko Koshiba, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Effect of Preload on Left Ventricular Dyssynchrony in Patients with Dilated Cardiomyopathy: Assessment with Real-Time Three-Dimensional Echocardiography.,
American Society of Echocardiography 2010 21st Annual Scientific Sessions, San Diego, Jun. 2010. H Takashima, Hirotsugu Yamada, Kenya Kusunose, S Nishio, N Tomita, C Mimura, K Endo, M Yamanaka, J Miki, T Niki, Koji Yamaguchi, Kunihiko Koshiba, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Association of Carotid Artery Atherosclerosis with Aortic Valve Sclerosis.,
American Society of Echocardiography 2010 21st Annual Scientific Sessions, San Diego, Jun. 2010. Hirotsugu Yamada, Kenya Kusunose, S Nishio, J Miki, N Tomita, H Takashima, C Mimura, M Yamanaka, T Niki, Koji Yamaguchi, Kunihiko Koshiba, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Identification of Pseudonormal / Restrictive Transmitral Flow Velocity Pattern Using its Response to Nitroglycerin Spray Oral Administration.,
American Society of Echocardiography 2010 21st Annual Scientific Sessions, San Diego, Jun. 2010. Hirotsugu Yamada, Kenya Kusunose, S Nishio, N Tomita, J Miki, Toshiyuki Niki, Koji Yamaguchi, Kunihiko Koshiba, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Identification of Pseudonormal Transmitral Flow Velocity Pattern using its Change by Nitroglycerin Spray Oral Administration.,
American College of Cardiology 2010, Mar. 2010. Kenya Kusunose, Hirotsugu Yamada, S Nishio, N Tomita, J Miki, T Niki, Koji Yamaguchi, Kunihiko Koshiba, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Doppler Echocardiographic Estimation of Left Ventricular End-diastolic Pressure in Challenging,
第74回日本循環器学会総会・学術集会, Mar. 2010. S Nishio, Hirotsugu Yamada, Kenya Kusunose, N Tomita, J Miki, T Niki, Koji Yamaguchi, Kunihiko Koshiba, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Evaluation of Secondary Pulmonary Hypertension by Tricuspid Annular Velocity Profile Using Pulsed Tissue Doppler Imaging.,
第74回日本循環器学会総会・学術集会, Mar. 2010. N Tomita, Hirotsugu Yamada, Kenya Kusunose, S Nishio, K Endo, H Takashima, C Mimura, T Niki, Koji Yamaguchi, Kunihiko Koshiba, Takashi Iwase, Yoshio Taketani, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Detection of Patent Foramen Ovale by Contrast Realtime 3-dimensional Transesophageal Echocardiography.,
第74回日本循環器学会総会・学術集会, Mar. 2010. K Endo, Hirotsugu Yamada, Kenya Kusunose, S Nishio, N Tomita, J Miki, T Niki, Koji Yamaguchi, Kunihiko Koshiba, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike, Ken Saito and Masataka Sata :
N-3 Fatty Acids, IMT and CKD as Risk Factors in Coronary Artery Disease.,
第74回日本循環器学会総会・学術集会, Mar. 2010. S Nishio, Hirotsugu Yamada, Kenya Kusunose, N Tomita, J Miki, K Endo, T Niki, Koji Yamaguchi, Kunihiko Koshiba, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Clinical Evaluation of Stiffness Parameter beta of Common Carotid Artery Obtained by Echo-tracking Method in Coronary Heart Disease.,
第74回日本循環器学会総会・学術集会, Mar. 2010. T Niki, Takeshi Soeki, Kunihiko Koshiba, Kenya Kusunose, Koji Yamaguchi, Y Hirata, N Tomita, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Role of Circulating High-Mobility Group Box-1 (HMGB1) in Patients with Coronary Artery Disease.,
第74回日本循環器学会総会・学術集会, Mar. 2010. Takashi Iwase, Shoichiro Takao, Masashi Akaike, K Adachi, Y Sumitomo, Shusuke Yagi, T Niki, Kenya Kusunose, N Tomita, Y Hirata, Koji Yamaguchi, Kunihiko Koshiba, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Ken-ichi Aihara, Masafumi Harada, Hiromu Nishitani and Masataka Sata :
Utility of Cardiac Magnetic Resonance for Detection of Cardiac Involvement in Female Carriers of Duchenne Muscular Dystrophy.,
第74回日本循環器学会総会・学術集会, Mar. 2010. Tetsuzo Wakatsuki, Koji Yamaguchi, T Niki, Kenya Kusunose, Kunihiko Koshiba, Takashi Iwase, Yoshio Taketani, N Tomita, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Long-Term Local Inflammatory and Coagulative Responses after Coronary Artery Stenting with Drug-Eluting Stent.,
第74回日本循環器学会総会・学術集会, Mar. 2010. Takeshi Soeki, Kunihiko Koshiba, T Niki, Kenya Kusunose, Koji Yamaguchi, Y Hirata, N Tomita, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Masashi Akaike, Kenji Kangawa and Masataka Sata :
Ghrelin Protects Heart against Ischemia-Induced Arrhythmias by Preserving Connexin43 Protein.,
第74回日本循環器学会総会・学術集会, Mar. 2010. Kenya Kusunose, Hirotsugu Yamada, S Nishio, N Tomita, J Miki, T Niki, Koji Yamaguchi, Kunihiko Koshiba, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Detection of Myocardial Amyloid Involvement Using 2-Dimentional Speckle Tracking Echocardiography: Utilization of Inner and Outer Myocardial Strain and Strain Rate.,
第74回日本循環器学会総会・学術集会, Mar. 2010. Koji Yamaguchi, Tetsuzo Wakatsuki, T Niki, Kenya Kusunose, Kunihiko Koshiba, Yoshio Taketani, Takashi Iwase, N Tomita, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Time-Dependent Changes of Local Coagulative Response up to Five Years after Sirolimus-Eluting Stent Implantation.,
第74回日本循環器学会総会・学術集会, Mar. 2010. C Mimura, Hirotsugu Yamada, Kenya Kusunose, S Nishio, N Tomita, J Miki, H Takashima, T Niki, Koji Yamaguchi, Kunihiko Koshiba, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Predictive Value of Subepicardial Fat Thickness in Coronary Artery Sclerosis in Comparison with Intima-media Thickness,
第74回日本循環器学会総会・学術集会, Mar. 2010. Koji Yamaguchi, Tetsuzo Wakatsuki, T Niki, Kenya Kusunose, Kunihiko Koshiba, Shusuke Yagi, Yoshio Taketani, Takashi Iwase, N Tomita, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Predictors of Local Persistent Hypercoagulability After Sirolimus-eluting Stent Implantation: Implication for Correlates of Late Stent Thrombosis.,
American Heart Association 2009, Nov. 2009. Hirotsugu Yamada, Kenya Kusunose, S Nishio, N Tomita, K Endo, H Takashima, C Mimura, T Niki, Koji Yamaguchi, Kunihiko Koshiba, Yoshio Taketani, Shusuke Yagi, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Prognostic Value of Changes in Transmitral Flow Velocity Pattern During Leg Positive Pressure in Mild Heart Failure: A Clinical Application of "Preload Stress Echocardiography",
American Heart Association 2009, Nov. 2009. Tetsuzo Wakatsuki, T Niki, Kenya Kusunose, Koji Yamaguchi, Kunihiko Koshiba, Shusuke Yagi, N Tomita, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Long-Term Local Inflammatory Response After Coronary Artery Stenting. Bare Metal vs Sirolimus-Eluting vs Paclitaxel-Eluting Stent.,
American Heart Association 2009, Nov. 2009. Tetsuzo Wakatsuki, T Niki, Kenya Kusunose, Koji Yamaguchi, Kunihiko Koshiba, Shusuke Yagi, N Tomita, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Long-Term Local Inflammatory Response After Coronary Artery Stenting with Drug-Eluting Stent.,
American Heart Association 2009, Nov. 2009. Kunihiko Koshiba, Takeshi Soeki, T Niki, Kenya Kusunose, Y Hirata, Koji Yamaguchi, Shusuke Yagi, N Tomita, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Masashi Akaike, Kenji Kangawa and Masataka Sata :
C-type Natriuretic Peptide Ameliorates the Progression of Experimental Autoimmune Myocarditis.,
American Heart Association 2009, Nov. 2009. Tetsuzo Wakatsuki, Koji Yamaguchi, T Niki, Kenya Kusunose, Kunihiko Koshiba, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Long-term local inflammatory response after coronary artery stenting -BMS vs SES vs PES-.,
ESC Congress 2009, Aug. 2009. Takeshi Soeki, T Niki, Kunihiko Koshiba, Kenya Kusunose, Koji Yamaguchi, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Plasma concentration of pentraxin 3 is a useful marker for monitoring the anti-plaque effect of telmisartan.,
ESC Congress 2009, Aug. 2009. Koji Yamaguchi, Tetsuzo Wakatsuki, T Niki, Kenya Kusunose, Kunihiko Koshiba, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Local persistent hypercoagulability after drug-eluting stent implantation: siroliumus-eluting stent vs. paclitaxel-eluting stent.,
ESC Congress 2009, Aug. 2009. Y Fukuda, Takeshi Soeki, N Fukuda, S Morishita, K Sakabe, H Shinohara, Y Tamura, Masashi Akaike, Tetsuzo Wakatsuki, Hirotsugu Yamada, Takashi Iwase, Shusuke Yagi, Kunihiko Koshiba, Koji Yamaguchi, Kenya Kusunose, T Niki and Masataka Sata :
Pentraxin 3, a Novel Inflammatory Marker, Predicts Left Ventricular Remodeling in Patients with Acute Myocardial Infarction.,
73th Annual scientific meeting of the Japanese circulation society, Mar. 2009. Shusuke Yagi, Masashi Akaike, Takashi Iwase, Kenya Kusunose, T Niki, Y Hirata, Koji Yamaguchi, Kunihiko Koshiba, N Tomita, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, S Yoshida, Y Sumitomo, Ken-ichi Aihara, Toshio Matsumoto and Masataka Sata :
Bosentan, an Endothelin Receptor Antagonist, Exerts Protective Actions against Systemic Sclerosis-related Peripheral Circulation Insufficiency.,
73th Annual scientific meeting of the Japanese circulation society, Mar. 2009. Y Hirata, H Iwata, K Nakamura, Y Sakai, N Tomita, T Niki, Kenya Kusunose, Koji Yamaguchi, Kunihiko Koshiba, Shusuke Yagi, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Synthetic Prostacycline Agonist, ONO-1301, Ameliorates Left Ventricular Dysfunction and Cardiac Fibrosis in Cardiomyopathic Hamsters.,
73th Annual scientific meeting of the Japanese circulation society, Mar. 2009. Kenya Kusunose, Hirotsugu Yamada, S Nishio, N Tomita, T Niki, Koji Yamaguchi, Kunihiko Koshiba, Shusuke Yagi, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Prediction of Cardiac Response to Preload Augmentation by Dual Doppler Echocardiography and Left Arial Volume Auto Tracking System.,
73th Annual scientific meeting of the Japanese circulation society, Mar. 2009. M Yamanaka, Hirotsugu Yamada, Kenya Kusunose, N Tomita, S Nishio, T Niki, Koji Yamaguchi, Kunihiko Koshiba, Shusuke Yagi, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike, Shinji Nagahiro and Masataka Sata :
Utilization of Echocardiography in Stroke Care Unit of Tokushima University Hospital.,
73th Annual scientific meeting of the Japanese circulation society, Mar. 2009. Takeshi Soeki, T Niki, Kunihiko Koshiba, Y Hirata, N Tomita, Kenya Kusunose, Koji Yamaguchi, Shusuke Yagi, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Masashi Akaike, H Satoh and Masataka Sata :
Plasma Concentration of Pentraxin 3 is a Useful Marker for Monitoring the Anti-plaque Effect of Telmisartan.,
73th Annual scientific meeting of the Japanese circulation society, Mar. 2009. Shusuke Yagi, Masashi Akaike, Ken-ichi Aihara, S Yoshida, Y Sumitomo, Kenya Kusunose, T Niki, Y Hirata, Koji Yamaguchi, Kunihiko Koshiba, Takashi Iwase, N Tomita, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Toshio Matsumoto and Masataka Sata :
Pitavastatin Exerts LDL Cholesterol Reduction-independent Protective Action for Cardiac and Renal Function in Patients with Dyslipidemia.,
73th Annual scientific meeting of the Japanese circulation society, Mar. 2009. Shusuke Yagi, Masashi Akaike, Ken-ichi Aihara, S Yoshida, Y Sumitomo, Kenya Kusunose, T Niki, Y Hirata, Koji Yamaguchi, Kunihiko Koshiba, Takashi Iwase, N Tomita, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Toshio Matsumoto and Masataka Sata :
Plasma Aldosterone Concentration is Associated with Cognitive Impairement in Patients with Hypertension.,
73th Annual scientific meeting of the Japanese circulation society, Mar. 2009. Koji Yamaguchi, Tetsuzo Wakatsuki, T Niki, Kenya Kusunose, Kunihiko Koshiba, N Tomita, Shusuke Yagi, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Local Persistent Hypercoagulability after Drug-Eluting Stent Implantation: Sirolimus-Eluting Stent vs. Paclitaxel-Eluting Stent.,
73th Annual scientific meeting of the Japanese circulation society, Mar. 2009. Takashi Iwase, Shoichiro Takao, Masashi Akaike, K Adachi, Y Sumitomo, Shusuke Yagi, T Niki, Kenya Kusunose, N Sakamoto, Y Hirata, Koji Yamaguchi, Kunihiko Koshiba, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Ken-ichi Aihara, Masafumi Harada, Hiromu Nishitani and Masataka Sata :
Early Detection of Myocardial Damage in Female Carriers of Duchenne Muscular Dystrophy - the Utility of Cardiac Magnetic Resonance.,
73th Annual scientific meeting of the Japanese circulation society, Mar. 2009. Hirotsugu Yamada, Kenya Kusunose, N Tomita, S Nishio, T Niki, Koji Yamaguchi, Kunihiko Koshiba, Shusuke Yagi, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Angiotensin-II Receptor Blocker Prevents the Deterioration of Left Ventricular Geometry and Diastolic Function in Hypertrophic Cardiomyopathy.,
73th Annual scientific meeting of the Japanese circulation society, Mar. 2009. Takeshi Soeki, Kunihiko Koshiba, T Niki, Y Hirata, N Tomita, Kenya Kusunose, Koji Yamaguchi, Shusuke Yagi, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Effect of Ghrelin on Autonomic Activity in Healthy Volunteers.,
73th Annual scientific meeting of the Japanese circulation society, Mar. 2009. Kenya Kusunose, Hirotsugu Yamada, S Nishio, N Tomita, T Niki, Koji Yamaguchi, Kunihiko Koshiba, Shusuke Yagi, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Elevation of Left Ventricular End-diastolic Pressure Enhances Mismatch between Mitral Inflow and Annular Motion.,
73th Annual scientific meeting of the Japanese circulation society, Mar. 2009. S Nishio, Hirotsugu Yamada, Kenya Kusunose, N Tomita, T Niki, Koji Yamaguchi, Kunihiko Koshiba, Shusuke Yagi, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Clinical utility of B-Flowimaging on ultrasound examination of carotid artery.,
73th Annual scientific meeting of the Japanese circulation society, Mar. 2009. M Yamanaka, Kenya Kusunose, Hirotsugu Yamada, S Nishio, N Tomita, T Niki, Koji Yamaguchi, Kunihiko Koshiba, Shusuke Yagi, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Postsystolic Shortening is Superior to Peak Systolic Strain on the Prediction of Ischemia in Normal Wall Motion Segments.,
73th Annual scientific meeting of the Japanese circulation society, Mar. 2009. Tetsuzo Wakatsuki, Koji Yamaguchi, T Niki, Kenya Kusunose, Kunihiko Koshiba, Shusuke Yagi, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Long-Term Local Inflammatory Response after Coronary Artery Stenting -BMS vs. SES vs. PES-,
73th Annual scientific meeting of the Japanese circulation society, Mar. 2009. Hirotsugu Yamada, Kenya Kusunose, S Nishio, N Tomita, T Niki, Koji Yamaguchi, Kunihiko Koshiba, Shusuke Yagi, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
The Mitral L-wave Predicts Adverse Response to Volume Overloading in Patients with Atrial Fibrillation.,
58th American College of Cardiology, Mar. 2009. S Nishio, Hirotsugu Yamada, Kenya Kusunose, N Tomita, T Niki, Koji Yamaguchi, Kunihiko Koshiba, Shusuke Yagi, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Tricuspid Annular Velocity Profile by Pulsed Tissue Doppler Imaging for the Assessment of Serial Change of Pulmonary Artery Pressure in Secondary Pulmonary Hypertension.,
58th American College of Cardiology, Mar. 2009. Tetsuzo Wakatsuki, K Yamaguchi, T Niki, Kenya Kusunose, K Koshiba, Hirotsugu Yamada, Takeshi Soeki, Shusuke Yagi, Takashi Iwase, Masashi Akaike and Masataka Sata :
Long-term endothelial dysfunction after coronary artery stenting with drug-eluting stent associated with local inflammatory response.,
American Heart Association 2008, New Orleans, Nov. 2008. K Yamaguchi, Tetsuzo Wakatsuki, T Niki, Kenya Kusunose, K Koshiba, Shusuke Yagi, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Local hypercoagulability and endothelial dysfunction after sirolimus-eluting stent implantation: implication for late stent thrombosis.,
American Heart Association 2008, New Orleans, Nov. 2008. Takeshi Soeki, T Niki, K Koshiba, Kenya Kusunose, K Yamaguchi, Hirotsugu Yamada and Tetsuzo Wakatsuki :
Elevated concentration of Pentraxin 3 is associated with coronary plaque vulnerability.,
ESC Congress 2008, Munich, Aug. 2008. Tetsuzo Wakatsuki, K Yamaguchi, Kenya Kusunose, T Niki, K Koshiba, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Long-term local inflammatory response after coronary artery stenting with drug-eluting stent.,
ESC Congress 2008, Munich, Aug. 2008. K Koshiba, Takeshi Soeki, T Niki, Kenya Kusunose, K Yamaguchi, Hirotsugu Yamada and Tetsuzo Wakatsuki :
C-type natriuretic peptide ameliorates the progression of experimental autommune myocarditis.,
ESC Congress 2008, Munich, Aug. 2008. S Nishio, Hirotsugu Yamada, H Motonari, H Okada, Kenya Kusunose, Y Tadatsu, M Sato, H Hiraoka, H Kawano, Takeshi Soeki, Tetsuzo Wakatsuki and Masashi Akaike :
Assessment of Left Atrial Ejection Force in Patients with Hypertensive Heart Disease.,
18th Annual Scientific Sessions of the American Society of Echocardiography, Toronto, Jun. 2008. Kenya Kusunose, Hirotsugu Yamada, S Nishio, M Sato, H Hiraoka, H Kawano, Y Tadatsu, Takeshi Soeki, Tetsuzo Wakatsuki and Masashi Akaike :
Importance of Left Atrial Function in Cardiac Response to Increment of Preload in Patients with Old Myocardial Infarction: Assessment by Automated Left Atrial Volume Tracking Method.,
18th Annual Scientific Sessions of the American Society of Echocardiography, Toronto, Jun. 2008. S Nishio, Hirotsugu Yamada, Kenya Kusunose, Y Tadatsu, M Sato, H Hiraoka, H Kawano, Takeshi Soeki, Tetsuzo Wakatsuki and Masashi Akaike :
Beat-To-Beat Variation of Mitral Annular Velocities in Atrial Fibrillation.,
18th Annual Scientific Sessions of the American Society of Echocardiography, Toronto, Jun. 2008. Hirotsugu Yamada, Kenya Kusunose, S Nishio, Y Tadatsu, M Sato, H Hiraoka, H Kawano, T Niki, K Yamaguchi, K Koshiba, Takeshi Soeki, Tetsuzo Wakatsuki and Masashi Akaike :
The Mitral L-Wave Predicts the Cardiac Response to Preload Increment in Atrial Fibrillation.,
18th Annual Scientific Sessions of the American Society of Echocardiography, Toronto, Jun. 2008. S Nishio, Hirotsugu Yamada, Kenya Kusunose, Y Tadatsu, M Sato, H Hiraoka, H Kawano, T Niki, K Yamaguchi, K Koshiba, Takeshi Soeki, Tetsuzo Wakatsuki and Masashi Akaike :
Usefulness of Tei Index in Atrial Fibrillation: Assessment by Dual Doppler Echocardiography.,
18th Annual Scientific Sessions of the American Society of Echocardiography, Toronto, Jun. 2008. Kenya Kusunose, K Takechi, S Nishio, Y Tadatsu, T Niki, K Yamaguchi, K Koshiba, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike, M Choraku, Y Maeda and Hirotsugu Yamada :
Multicenter Trial for the Validation of Automated Function Imaging in Patients with Local Left Ventricular Asynergy (VANILLA Study),
18th Annual Scientific Sessions of the American Society of Echocardiography, Toronto, Jun. 2008. Kenya Kusunose, Hirotsugu Yamada, S Nishio, T Niki, K Yamaguchi, K Koshiba, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki and Masashi Akaike :
Role of Left Atrial Function for Pseudonormalization of Transmitral Flow Velocity Pattern in Patients with Hypertrophic Cardiomyopathy.,
18th Annual Scientific Sessions of the American Society of Echocardiography, Toronto, Jun. 2008. Kenya Kusunose, Hirotsugu Yamada, S Nishio, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki and Masashi Akaike :
Effect of Preload Increment on Early Diastolic Transmitral and Mitral Annular Velocities in Patients with Old Myocardial Infarction.,
The 16th Congress of the international Cardiac Doppler Society, Kobe, Apr. 2008. Hirotsugu Yamada, Kenya Kusunose, S Nishio, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki and Masashi Akaike :
The Mitral L-wave Predicts the Cardiac Response to an Increase of Preload in Atrial Fibrillation.,
The 16th Congress of the international Cardiac Doppler Society, Kobe, Apr. 2008. Kenya Kusunose, Hirotsugu Yamada, T Niki, T Nakajima, K Yamaguchi, K Koshiba, Tomohito Kawano, Takeshi Soeki and Tetsuzo Wakatsuki :
Measurement of Left Atrial Volume Curve by Advanced 2D Tissue Tracking Technique: Validation by Contrast Multidetector Computed Tomography.,
17th Annual Scientific Sessions of the American Society of Echocardiography, Seattle, Jun. 2007. Hirotsugu Yamada, Kenya Kusunose, T Niki, T Nakajima, K Yamaguchi, K Koshiba, Tomohito Kawano, Takeshi Soeki and Tetsuzo Wakatsuki :
Assessment of the Cardiac Response to Increment of Preload in Patients with Atrial Fibrillation Using Dual Pulsed Doppler Echocardiography.,
17th Annual Scientific Sessions of the American Society of Echocardiography, Seattle, Jun. 2007. Kenya Kusunose, Hirotsugu Yamada, T Niki, T Nakajima, K Yamaguchi, K Koshiba, Tomohito Kawano, Takeshi Soeki, Tetsuzo Wakatsuki and Susumu Ito :
Relationship Between the Ratio of Peak Early diastolic Transmitral Flow and Mitral Annular Velocities and the Plasma B-Type Natriuretic Peptide (BNP) Concentration in Patients with Atrial Fibrillation: Assessment by Simultaneous Recording of Transmitral Flow and Mitral Annular Velocity.,
American College of Cardiology 56th Annual Scientific Session, New Orleans, Mar. 2007. K Koshiba, Takeshi Soeki, Y Fukuda, K Yamaguchi, Tomohito Kawano, Hirotsugu Yamada, Tetsuzo Wakatsuki and Kenji Kangawa :
Ghrelin prevents cardiac remodeling after myocardial infarction via the suppression of cardiac sympathetic nerve activity.,
World Congress of Cardiology 2006, Barcelona, Sep. 2006. Tetsuzo Wakatsuki, K Yamaguchi, Y Fukuda, K Koshiba, Tomohito Kawano, Takeshi Soeki and Hirotsugu Yamada :
Long-term endothelial dysfunction after coronary artery stenting with drug-eluting stent.,
World Congress of Cardiology 2006, Barcelona, Sep. 2006. Y Fukuda, Takeshi Soeki, K Yamaguchi, K Koshiba, Tomohito Kawano, Hirotsugu Yamada, Tetsuzo Wakatsuki and Kenji Kangawa :
Significance and therapeutic potential of C-type natriuretic peptide in myocardial infarction.,
World Congress of Cardiology 2006, Barcelona, Sep. 2006. Hirotsugu Yamada, Y Fukuda, K Yamaguchi, K Koshiba, Tomohito Kawano, Takeshi Soeki, Tetsuzo Wakatsuki and Susumu Ito :
Differentiation of Left Atrial Dysfunction by Changes in Transmitral Flow Velocities during Lower Body Positive Pressure.,
17th Annual Scientific Sessions of the American Society of Echocardiography, Baltimore, Jun. 2006. Hirotsugu Yamada, H Motonari, Y Fukuda, K Yamaguchi, K Koshiba, Tomohito Kawano, Takeshi Soeki, Tetsuzo Wakatsuki and Susumu Ito :
Effect of Aging on Left Atrial Myocardial Strain Evaluated by 2D Tissue Tracking during Lower Body Positive Pressure.,
17th Annual Scientific Sessions of the American Society of Echocardiography, Baltimore, Jun. 2006. Tomohito Kawano, Yamato Fukuda, Tomonori Watanabe, Koji Yamaguchi, Kunihiko Koshiba, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Tomotsugu Tabata and Masahiro Nomura :
Coronary Atherosclerotic Plaque Stabilization of HMG-CoA Reductase inhibitor, Atorvastatin, Evaluated by 16-slice Multidetector-row CT (MDCT),
The 70th general meeting of a Japanese circulatory organ disease society, Mar. 2006. Takeshi Soeki, Y Fukuda, K Koshiba, K Yamaguchi, Tomohito Kawano, Hirotsugu Yamada, Tetsuzo Wakatsuki, Masahiro Nomura, K Kangawa and Susumu Ito :
Ghrelin Protects Myocardium Against Ischemia/Reperfusion Injury via Inhibiting Myocardial Apoptosis.,
American College of Cardiology 55th Annual Scientific Session, Atlanta, Mar. 2006. Tomotsugu Tabata, H Tanaka, E Kimura, K Harada, Tetsuzo Wakatsuki, T Yamamoto, A Saito, K Uehara, N Kageyama, Hirotsugu Yamada and T Oki :
Longitudinal Myocardial Displacement and Strain Rate in the Hypertrophied Heart Evaluated by Tissue Strain Imaging With Doppler Angle Correction and Tissue Tracking Technique.,
American College of Cardiology 52st Annual Scientific Session, Chicago, Mar. 2003. H Tanaka, Tomotsugu Tabata, Eriko Kimura, Kenji Harada, Tetsuzo Wakatsuki, Masahiro Nomura and Susumu Ito :
Quantitative assessment of myocardial viability of low dose dobutamine stress echocardiography applying tissue strain imaging,
American Heart Association Scientific Sessions 2003, Orlando, 2003. E Kimura, Tomotsugu Tabata, H Tanaka, Tetsuzo Wakatsuki, T Yamamoto, A Saito, Hirotsugu Yamada and T Oki :
Determinants of the Left Ventricular Myocardial Contractility in Patients with Hypertension Evaluated by Newly Developed Averaged Myocardial Velocity Profile.,
American Society of Echocardiography 13th Annual Scientific Sessions, Orlando, Jun. 2002. H Tanaka, Tomotsugu Tabata, E Kimura, Tetsuzo Wakatsuki, T Yamamoto, A Saito, Hirotsugu Yamada and T Oki :
Temporal Change in the Left Ventricular Transmyocardial Systolic Velocity Profile Evaluated by Color Tissue Doppler Imaging.,
American Society of Echocardiography 13th Annual Scientific Sessions, Orlando, Jun. 2002. H Tanaka, Tomotsugu Tabata, E Kimura, Tetsuzo Wakatsuki, T Yamamoto, A Saito, Hirotsugu Yamada and T Oki :
Noninvasive Assessment of Myocardial Ischemia and Necrosis Using a Newly Developed Tissue Doppler Myocardial Velocity Profile.,
American Society of Echocardiography 13th Annual Scientific Sessions, Orlando, Jun. 2002. H Tanaka, Tomotsugu Tabata, E Kimura, Tetsuzo Wakatsuki, T Yamamoto, A Saito, Hirotsugu Yamada and T Oki :
Effect of Angiotensin II Receptor Antagonist on Left Ventricular Myocardial Relaxation Abnormality in Hypertensive Patients: Evaluation Using a Newly Developed Myocardial Velocity Profile.,
American Society of Echocardiography 13th Annual Scientific Sessions, Orlando, Jun. 2002. Tomotsugu Tabata, T Oki, H Tanaka, E Kimura, Tetsuzo Wakatsuki, T Yamamoto, A Saito and Hirotsugu Yamada :
Novel Index for Evaluating Wall Motion Abnormality Using Newly Developed Angle-Corrected Tissue Strain Imaging.,
American Society of Echocardiography 13th Annual Scientific Sessions, Orlando, Jun. 2002. Tomotsugu Tabata, T Oki, H Tanaka, E Kimura, Tetsuzo Wakatsuki, T Yamamoto, A Saito and Hirotsugu Yamada :
Quantitative Analysis Of The Left Ventricular Segmental Contractility In The Normal Subjects Using Newly Developed Angle-corrected Tissue Strain Imaging.,
American Society of Echocardiography 13th Annual Scientific Sessions, Orlando, Jun. 2002. Tomotsugu Tabata, T Oki, H Tanaka, Y Onose, M Matsuoka, T Tada, T Yamamoto, Tetsuzo Wakatsuki and Hirotsugu Yamada :
Myocardial Characterization of Cardiac Amyloidosis Using Myocardial Velocity Profile: Comparison With Hypertensive Heart Disease.,
American Heart Association's Scientific Sessions, Anaheim, Nov. 2001. Tomotsugu Tabata, T Oki, Y Onose, M Matsuoka, T Tada, T Yamamoto, Tetsuzo Wakatsuki and Hirotsugu Yamada :
Novel Strategy for Detecting Myocardial Viability by Evaluating Improvement of Early Diastolic Left Ventricular Asynchrony Using Dobutamine Stress Pulsed Tissue Doppler Imaging.,
American Heart Association's Scientific Sessions, Anaheim, Nov. 2001. T Yamamoto, T Oki, Hirotsugu Yamada, H Tanaka, M Matsuoka, T Tada, Tetsuzo Wakatsuki and Tomotsugu Tabata :
Prognostic value of atrial systolic mitral annulus motion velocity in patients with dilated failing heart.,
American Society of Echocardiography 12th Annual Scientific Session, Seattle, Jun. 2001. H Tanaka, T Oki, Hirotsugu Yamada, Tetsuzo Wakatsuki, Tomotsugu Tabata, R Kanda, Y Abe and T Nabatame :
Early Diastolic Transmural Myocardial Velocity Profile Evaluated by Tissue Doppler Imaging in Normal Subjects and Patients With Left Ventricular Hypertrophy.,
American Society of Echocardiography 12th Annual Scientific Session, Seattle, Jun. 2001. Hirotsugu Yamada, T Oki, H Tanaka, Tetsuzo Wakatsuki, Tomotsugu Tabata, R Kanda, Y Abe and T Nabatame :
Accurate Measurement of Systolic Transmural Myocardial Velocity Profile Using Tissue Doppler Imaging in Normal Subjects And Patients with Hypertrophic Cardiomyopathy.,
American Society of Echocardiography 12th Annual Scientific Session, Seattle, Jun. 2001. Hirotsugu Yamada, T Oki, H Tanaka, M Matsuoka, T Yamamoto, T Tada, Tetsuzo Wakatsuki and Tomotsugu Tabata :
The Role of Short And Long Axes Function for Determining Late Diastolic Left Ventricular Filling in Patients with Hypertension: Assessment by Pulsed Tissue Doppler Imaging.,
American Society of Echocardiography 12th Annual Scientific Session, Seattle, Jun. 2001. Hirotsugu Yamada, T Oki, H Tanaka, M Matsuoka, T Yamamoto, T Tada, Tetsuzo Wakatsuki and Tomotsugu Tabata :
Potential Application of Tissue Doppler Imaging of the Left Ventricular Myocardium in Assessing Regional Diastolic Function in Patients with Hypertrophic Cardiomyopathy: Comparison with 1231-b-Methy1 Iodopheny1 Pentadecanoic Acid Myocardial Scintigraphy.,
American Society of Echocardiography 12th Annual Scientific Session, Seattle, Jun. 2001. Hirotsugu Yamada, T Oki, Y Onose, M Matsuoka, T Yamamoto, Tomotsugu Tabata and Tetsuzo Wakatsuki :
Ultrasonic myocardial characterization of cardiac amyloidosis using tissue Doppler imaging.,
11th Annual Scientific Sessions American Society of Echocardiography, Chicago, Jun. 2000. M Matsuoka, T Oki, Y Mishiro, Hirotsugu Yamada, Y Onose, Tetsuzo Wakatsuki and Tomotsugu Tabata :
Quantitative assessment of left ventricular myocardial viability using systolic mitral annular descent velocity: A study with dobutamine stress pulsed tissue Doppler imaging.,
49th Annual Scientific Session of American College of Cardiology, Anaheim, Mar. 2000. Hirotsugu Yamada, M Matsuoka, T Oki, Y Mishiro, Y Onose, Tetsuzo Wakatsuki and Tomotsugu Tabata :
Quantitative assessment of left ventricular myocardial viability using systolic mitral annular descent velocity: A study with dobutamine stress pulsed tissue Doppler imaging.,
49th Annual Scientific Session of American College of Cardiology, Anaheim, Mar. 2000. Hirotsugu Yamada, T Oki, Y Mishiro, Y Onose, M Matsuoka, K Manabe, Y Kageji, Tetsuzo Wakatsuki, Y Oishi, Akiyoshi Nishikado and Susumu Ito :
Quantitative assessment of myocardial echo contrast using time-intensity curve.,
First International Kyoto Symposium on Ultrasound Contrast Imaging, Kyoto, Oct. 1999. Tomotsugu Tabata, T Oki, Hirotsugu Yamada, K Fukuda, M Abe, Y Onose, Tetsuzo Wakatsuki, H Fujinaga, K Sakabe, J Ikata, Akiyoshi Nishikado and A Iuchi :
Relationship between left atrial appendage function and plasma concentration of atrial natriuretic peptide.,
70th American Heart Asssociation, Orlando, Nov. 1997. Tomotsugu Tabata, T Oki, Hirotsugu Yamada, M Abe, K Manabe, K Fukuda, Tetsuzo Wakatsuki, K Sakabe, A Iuchi and Susumu Ito :
Relationship between left atrial appendage function and plasma concentration of artrial natriuretic peptide.,
19th Congress of the European Society of Cardiology, Stockholm, Aug. 1997. T Oki, Tomotsugu Tabata, Hirotsugu Yamada, Tetsuzo Wakatsuki, H Shinohara, Akiyoshi Nishikado, A Iuchi, N Fukuda and Susumu Ito :
Clinical application of pulsed Doppler tissue imaging for assessing abnormal relaxation of the left ventricle.,
69th American Heart Association, New Orleans, Nov. 1996. Hirotsugu Yamada, T Oki, Tomotsugu Tabata, K Manabe, K Fukuda, M Abe, A Iuchi, Akiyoshi Nishikado, Tetsuzo Wakatsuki, K Sakabe, J Ikata and Susumu Ito :
Assessment of myocardial circumferential shorttening of the left ventricular wall using pulsed Doppler tissue imaging.,
69th American Heart Association, New Orleans, Nov. 1996. T Oki, A Iuchi, Tomotsugu Tabata, Hirotsugu Yamada, Akiyoshi Nishikado, Tetsuzo Wakatsuki, H Shinohara, N Fukuda and Susumu Ito :
Non-invasive assessment of left ventricular relaxation by pulsed Doppler tissue imaging: comparison with cardiac catheterization.,
18th Congress of the European Society of Cardiology, Birmingham, Aug. 1996. K Sakabe, Tetsuzo Wakatsuki, H Shinohara, Akiyoshi Nishikado, Hirotsugu Yamada, Tomotsugu Tabata, A Iuchi, T Oki and Susumu Ito :
Coronary flow velocity immediately after reperfusion reflects myocardial microcirculation in canine acute myocardial infarction models.,
45th American College of Cardiology, Orlando, Mar. 1996. Tetsuzo Wakatsuki, Yutaka Nakaya, Yukiko Miyoshi, XR Zeng, Masahiro Nomura, Ken Saito and Isao Inoue :
Effect of vasopressin ATP-sensitive and Ca²⁺-activated K⁺ channels of coronary arterial smooth muscle cell,
International Symposium "smooth muscle" -Assessment of current knowledges-, Fukuoka, 1992. Yukiko Miyoshi, Tetsuzo Wakatsuki, Masahiro Nomura, Ken Saito, Yutaka Nakaya and Isao Inoue :
Endothelin blocks ATP-sensitive K+ channels and depolarizes smooth muscle cells of porcine artery,
International Symposium "smooth muscle" -Assessment of current knowledges-, Fukuoka, 1992. Yutaka Nakaya, Masahiro Nomura, Kimiko Nakayasu, Tetsuzo Wakatsuki, Yukiko Miyoshi, Shigenobu Bando and Susumu Ito :
Diagnosis of left ventricular hypertrophy by single moving dipole,
The 8th International Conference on Biomagnetism, Münster, Germany, 1991. R Bando, Koji Yamaguchi, Tetsuzo Wakatsuki, Takayuki Ise, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Predictors of late lumen enlargement after drug coated balloon angioplasty for denovo coronary lesions,
ACC 2024, Atlanta, Apr. 202. 伊藤直司, 八木秀介, 佐田政隆, 若槻哲三, 添木武, 山田博胤, 山口浩司, 高橋智子, 手束一貴, 松浦朋美 :
ペースメーカー電池交換術後に発症した血管性浮腫の1例,
第131回日本内科学会四国地方会, 2024年12月. 玉上大暉, 森西啓介, 平良竣也, 野田康裕, 林昌晃, 近田優介, 大藤純, 坂東遼, 髙橋智紀, 川端豊, 伊勢孝之, 山口浩司, 若槻哲三, 佐田政隆 :
ローターブレーターのドライブシャフトシース破損の検証実験,
第30回日本心血管インターベンション治療学会(CVIT)中国四国地方会 2024年9月7日(土)∼8日(日) 岡山, 2024年9月. 野田康裕, 森西啓介, 平良竣也, 玉上大暉, 林昌晃, 近田優介, 大藤純, 坂東遼, 髙橋智紀, 川端豊, 伊勢孝之, 山口浩司, 若槻哲三, 佐田政隆 :
Impella挿入患者の搬送に伴う人員と機器選定に苦慮した一例,
第30回日本心血管インターベンション治療学会(CVIT)中国四国地方会, 2024年9月. 川端豊, 伊勢孝之, 坂東遼, ロバートゼング, 髙橋智紀, 上野理絵, 山口浩司, 若槻哲三, 佐田政隆 :
弓部大動脈に高度屈曲を有する外科的大動脈弁置換術後の人工弁機能不全に対して TF-TAVIを施行した1例,
第30回日本心血管インターベンション治療学会(CVIT)中国四国地方会, 2024年9月. 坂東遼, 山口浩司, 髙橋智紀, 川端豊, 伊勢孝之, 若槻哲三, 佐田政隆 :
高出血リスク患者の急性冠症候群に対して薬剤塗布バルーンで治療を行い遠隔期に冠動脈瘤形成を認めた一例,
第30回日本心血管インターベンション治療学会(CVIT)中国四国地方会, 2024年9月. 髙橋智紀, 若槻哲三, 髙橋智子, 坂東遼, ロバートゼング, 川端豊, 上野理絵, 伊勢孝之, 山口浩司, 佐田政隆 :
弁の石灰化と動脈蛇行の合併はTAVR術後の予後不良因子である:大動脈弁狭窄症患者のサブタイプ解析,
第30回日本心血管インターベンション治療学会(CVIT)中国四国地方会, 2024年9月. 山口浩司, 若槻哲三, 坂東遼, 髙橋智紀, 川端豊, 伊勢孝之, 佐田政隆 :
高度石灰化病変に対して使用したDrug coated balloonが抜去困難・断裂した一例,
第30回日本心血管インターベンション治療学会(CVIT)中国四国地方会, 2024年9月. 山口浩司, 若槻哲三, 坂東遼, 髙橋智紀, 川端豊, 伊勢孝之, 佐田政隆 :
アブレーション後に生じた肺静脈厚土井狭窄病変に対する薬剤塗布バルーン有効2症例,
第32回日本心血管インターベンション治療学会; CVIT 2024, 2024年7月. S Kashima, TOMONORI Takahashi, K Nagano, R Bando, Yutaka Kawabata, Takayuki Ise, Koji Yamaguchi, Tetsuzo Wakatsuki and Masataka Sata :
Association of High Lipoprotein(a) Levels with Adverse Outcomes in Patients with Stable Angina Undergoing Stentless PCI with Drug-coated balloon,
第32回日本心血管インターベンション治療学会; CVIT 2024, Jul. 2024. Tserensonom Munkhtsetseg, 八木秀介, 伊勢孝之, 川端豊, 門田宗之, 山口浩司, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
経カテーテル的大動脈弁置換術後血清Lp【a】の上昇は予後不良のリスクファクター,
第45回日本循環制御医学会総会・学術集会, 2024年6月. 西條良仁, 山田博胤, Zheng Robert, 髙橋智紀, 坂東遼, 高橋智子, 原知也, 門田宗之, 川端豊, 上野理絵, 松浦朋美, 伊勢孝之, 山口浩司, 八木秀介, 添木武, 若槻哲三, 笹聡一郎, 滝沢宏光, 佐田政隆 :
Mechanical circulatory supportを要した重症がん治療関連心機能障害の1例,
第124回日本循環器学会中国・四国合同地方会, 2024年6月. 八木一成, 八木秀介, 西條良仁, 高橋智子, Zheng Robert, 坂東遼, 髙橋智紀, 原知也, 門田宗之, 川端豊, 上野理絵, 松浦朋美, 伊勢孝之, 山口浩司, 山田博胤, 添木武, 若槻哲三, 佐田政隆, 秦広樹, 菅野幹雄 :
心室中隔欠損症・感染性心内膜炎を合併した大動脈縮窄証による二次性高血圧症の一例,
第124回日本循環器学会中国・四国合同地方会, 2024年6月. 八木秀介, 坂東遼, 山口浩司, 添木武, 赤池雅史, 若槻哲三, 佐田政隆 :
腎血管性高血圧を合併した左室駆出率の保たれた心不全の1例,
第130回日本内科学会四国地方会, 2024年6月. Ryo Bando, Koji Yamaguchi, Tetsuzo Wakatsuki, Yutaka Kawabata, TOMONORI Takahashi, Hayato Orino, Issei Yagi, TOMONORI Takahashi, Zheng Robert, Yoshihito Saijyo, Tomoya Hara, Muneyuki Kadota, Tomomi Matsuura, Takayuki Ise, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Predictors of Late Lumen Enlargement after Drug Coated Balloon Angioplasty for de Novo Coronary Lesions,
第88回日本循環器学会学術集会 JCS2024, Mar. 2024. 川端豊, 山口浩司, 若槻哲三, 髙橋智紀, 坂東遼, 西條良仁, 門田宗之, 松浦朋美, 伊勢孝之, 八木秀介, 添木武, 佐田政隆 :
Microvasculature and Gene Expression in Pericoronary Adipose Tissue According to Coronary Plaque Progression Stage in Fresh Cadavers,
第88回日本循環器学会学術集会, 2024年3月. Yoshihito Saijyo, Hirotsugu Yamada, 長野絋平, 折野逸人, 八木一成, TAKAHASHI Tomoko, Zengu Robahto, BANDO Ryo, TOMONORI Takahashi, Tomoya Hara, Muneyuki Kadota, Yutaka Kawabata, Tomomi Matsuura, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Incremental Value of Relative Apical Sparing Index for Discrimination of Cardiac Amyloidosis Subtypes,
第88回日本循環器学会学術集会, Mar. 2024. M Tserensonom, Shusuke Yagi, Takayuki Ise, Yutaka Kawabata, Muneyuki Kadota, Tomoya Hara, Kenya Kusunose, Koji Yamaguchi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
High Serum lipoprotein (a) level is a risk factor of poor prognosis after transcatheter aortic valve implantation,
第88回日本循環器学会学術集会 JCS2024, Mar. 2024. 八木一成, 西條良仁, 長野絋平, 折野逸人, 吉田直史, 髙橋智子, Robert Zheng, 坂東遼, 髙橋智紀, 原知也, 門田宗之, 川端豊, 松浦朋美, 伊勢孝之, 山口浩司, 八木秀介, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
ALおよびATTR心アミロイドーシス間のエコー図検査的特徴の相違に関する検討,
第123回日本循環器学会四国支部地方会, 2023年12月. 坂東遼, 山口浩司, 若槻哲三, 伊勢孝之, 川端豊, 髙橋智紀, Zheng Robert, 高橋智子, 吉田直史, 佐田政隆 :
薬剤塗布バルーン治療後に認めた遠隔期血管内腔拡大の長期観察,
第29回日本心血管インターヘンション治療学会(CVIT)中国四国地方会, 2023年9月. 長野紘平, 髙橋智紀, 折野逸人, 大谷啓太, 根岸佑典, 八木一成, 吉田直史, ロバートゼング, 坂東遼, 川端豊, 伊勢孝之, 山口浩司, 若槻哲三, 佐田政隆 :
高血圧リスク患者に対する薬剤コーティングバルーンを用いたstentless PCI 治療の長期成績,
第29回日本心血管インターヘンション治療学会(CVIT)中国四国地方会, 2023年9月. Ryo Bando, Tetsuzo Wakatsuki, Koji Yamaguchi, Yutaka Kawabata, TOMONORI Takahashi, Takayuki Ise and Masataka Sata :
Association of coronary plaque characteristics with vasa vasorum and local inflammation of epicardial adipose tissue in fresh cadavers,
CVIT2023, Aug. 2023. Koji Yamaguchi, Tetsuzo Wakatsuki, Ryo Bando, TOMONORI Takahashi, Yutaka Kawabata, Takayuki Ise and Masataka Sata :
Limitations of treatment for severely calcified lesions of renal arteries,
CVIT2023, Aug. 2023. Zengu Robahto, Muneyuki Kadota, Keita Ohtani, Hayato Orino, Yusuke Negishi, Tomoko Takahashi, Ryo Bando, Hiromitsu Seno, TOMONORI Takahashi, Yoshihito Saijyo, Yutaka Kawabata, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Koji Yamaguchi, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
A Case of Biopsy-Proven Giant Cell Myocarditis,
第37回日本心エコー図学会学術集会, Apr. 2023. Yuichiro Okushi, Hiromu Yamazaki, Tetsuzo Wakatsuki and Masataka Sata :
Predicting the Efficacy of n-3 Polyunsaturated Fatty Acids for Secondary Prevention of Coronary Artery Disease,
第87回日本循環器学会学術集会, Mar. 2023. Ryo Bando, Tetsuzo Wakatsuki, Koji Yamaguchi, Yutaka Kawabata, Ryota Miyamoto, Zengu Robahto, TOMONORI Takahashi, Yoshihito Saijyo, Rie Ueno, Muneyuki Kadota, Tomoya Hara, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Two-year Outcomes of Drug-coated Balloon-only Strategy for De Novo Lesions in Large Coronary Vessels,
第87回日本循環器学会学術集会, Mar. 2023. Yoshihito Saijyo, Yuichiro Okushi, Kenya Kusunose, Hirotsugu Yamada, Zengu Robahto, TOMONORI Takahashi, Hiromitsu Seno, Susumu Nishio, Rie Ueno, Muneyuki Kadota, Tomoya Hara, Yutaka Kawabata, Tomomi Matsuura, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Utility of Periodic Echocardiographic Surveillance for Early Detection of Cardiac Dysfunction from Chemotherapy in Breast Cancer Patients,
第87回日本循環器学会学術集会, Mar. 2023. Yutaka Kawabata, Tetsuzo Wakatsuki, Koji Yamaguchi, BANDO Ryo, Yoshihito Saijyo, Rie Ueno, Muneyuki Kadota, Tomoya Hara, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
The Impact of Coronary Plaque Progression Stage on Coronary Neovascularization Structures in Fresh Cadavers,
第87回日本循環器学会学術集会, Mar. 2023. Takayuki Ise, Shusuke Yagi, Rie Ueno, Muneyuki Kadota, Keita Ohtani, Yusuke Negishi, Ryota Miyamoto, BANDO Ryo, Zengu Robahto, Hiromitsu Seno, TOMONORI Takahashi, Yutaka Kawabata, Yoshihito Saijyo, Tomomi Matsuura, Kenya Kusunose, Koji Yamaguchi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Novel Home-based Cardiac Telerehabilitation System Using a Wearable Device and a Web Application,
第87回日本循環器学会学術集会, Mar. 2023. 楠瀬賢也, 若槻哲三, 佐田政隆 :
心エコー図法におけるAI医療の現状と未来像,
第33回日本心血管画像動態学会, 2023年1月. 吉田知哉, 伊勢孝之, 宮本亮太, 坂東遼, Robert Zheng, 瀬野弘光, 高橋智紀, 川端豊, 松浦朋美, 西條良仁, 門田宗之, 楠瀬賢也, 添木武, 山口浩司, 八木秀介, 山田博胤, 若槻哲三, 飯間努, 山本浩史, 佐田政隆 :
劇症型心筋炎に対してECPELLA導入で救命しえた症例,
第121回日本循環器学会四国地方会, 2022年12月. 高橋智紀, 楠瀬賢也, Robert Zheng, 瀬野弘光, 西條良仁, 門田宗之, 川端豊, 松浦朋美, 伊勢孝之, 山口浩司, 八木秀介, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
心房細動患者におけるイソプロテレノール負荷経食堂心エコー図法の有用性,
第121回日本循環器学会四国地方, 2022年12月. 吉田知哉, 若槻哲三, 山木浩二, 西條良仁, 川端豊, 伊勢孝之, 楠瀬賢也, 八木秀介, 山田博胤, 添木武, 佐田政隆 :
冠動脈入口部および鎖骨下動脈に特徴的な血管内超音波所見を認めた高安動脈炎の2例,
第70回日本心臓病学会学術集会, 2022年9月. 大櫛祐一郎, 楠瀬賢也, 瀬野弘光, 高橋智紀, 西條良仁, 伊勢孝之, 山口浩司, 八木秀介, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
心エコー検査によるサーベイランスのがん治療関連心筋障害への影響,
第5回日本腫瘍循環器学会学術集会, 2022年9月. 高橋智紀, 山口浩司, 若槻哲三, 宮本亮太, 坂東遼, 川端豊, 伊勢孝之, 佐田政隆 :
腫瘍塞栓が疑われた肺動脈塞栓症に対して下大静脈フィルターを腎静脈上部へ長期留置し得た1例,
第28回日本心血管インターベンション治療学会(CVIT)中国四国地方会, 2022年9月. 坂東遼, 若槻哲三, 川端豊, 山口浩司, 宮本亮太, 高橋智紀, 伊勢孝之, 佐田政隆 :
未個体遺体における冠動脈Lipid-richプラークと外膜vasa vasorumおよび局所心臓周囲脂肪の関連性の検討,
第28回日本心血管インターベンション治療学会(CVIT)中国四国地方会, 2022年9月. 松崎慶仁, 西條良仁, 伊勢孝之, 太田啓太, 折野逸人, 吉田知哉, 根岸佑典, 宮本亮太, 坂東遼, Rovert Zheng, 瀬野弘光, 高橋智紀, 上野理絵, 門田宗之, 原知也, 川端豊, 松浦朋美, 楠瀬賢也, 山口浩司, 八木秀介, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
急性A型大動脈解離をきたしたMarfan症候群の一例,
第265回徳島県医学学術集会, 2022年7月. 根岸佑典, 門田宗之, 山口浩司, 山田博胤, 折野逸人, 太田啓太, 吉田知哉, 宮本亮太, 坂東遼, Robert Zheng, 瀬野弘光, 高橋智紀, 西條良仁, 上野理絵, 原知也, 川端豊, 松浦朋美, 伊勢孝之, 楠瀬賢也, 八木秀介, 添木武, 若槻哲三, 田蒔昌憲, 佐田政隆 :
腎動脈拡張術により心不全の著名な改善を認めたCardiac Disturbance syndrome の1例,
第265回徳島県医学学術集会, 2022年7月. 楠瀬賢也, 若槻哲三, 佐田政隆 :
AI画像診断技術を用いた心筋梗塞の診断,
第30回日本心血管インターベンション治療学会学術集会, 2022年7月. Koji Yamaguchi, Tetsuzo Wakatsuki, TOMONORI Takahashi, Yutaka Kawabata, Takayuki Ise and Masataka Sata :
The impact of polymer duration on local coagulative responses following drug-eluting stent implantation,
第30回日本心血管インターベンション治療学会学術集会, Jul. 2022. 八木秀介, 伊勢孝之, 門田宗之, 川端豊, 原知也, 上野理絵, 西條良仁, 松浦朋美, 楠瀬賢也, 山口浩司, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
パンデミック下の臨床実習におけるオンライン医学教育の実際と問題点,
第265回徳島県医学学術集会, 2022年6月. 高橋里加子, 門田宗之, 伊勢孝之, 西條良仁, 川端豊, 松浦朋美, 楠瀬賢也, 山口浩司, 八木秀介, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
免疫抑制療法の導入により心機能が劇的に改善した巨細胞性心筋炎の一例,
第120回日本循環器学会中国・四国合同地方会, 2022年5月. 門田宗之, 楠瀬賢也, 八木秀介, 川端豊, 西條良仁, 松浦朋美, 伊勢孝之, 山口浩司, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
慢性心不全におけるサクビトリル / バルサルタンのナトリウム利尿ペプチドに対する急性反応の検討,
第120回日本循環器学会中国・四国合同地方会, 2022年5月. 楠瀬賢也, 山田博胤, 若槻哲三, 佐田政隆 :
大動脈弁閉鎖不全症の評価法,
第32回日本心血管画像動態学会, 2022年5月. ツェレンソノムムンフツェツェゲ, 八木秀介, 伊勢孝之, 福田大受, 門田宗之, 川端豊, 楠瀬賢也, 山口浩司, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
動脈硬化性疾患の高リスク患者において大動脈弁の石灰化と血清リポ蛋白との関連,
第9回日本心血管脳卒中学会学術集会, 2022年4月. Y Okushi, Kenya Kusunose, Zheng Robert, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Findings from the JROAD-DPC Registry across 6 Studies Conducted in a Year,
第86回日本循環器学術集会, Mar. 2022. Yutaka Kawabata, Tetsuzo Wakatsuki, Koji Yamaguchi, Daiju Fukuda, Yoshihito Saijyo, Muneyuki Kadota, Tomomi Matsuura, 伊勢孝之, Kenya Kusunose, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
First Assessment of Coronary Plaque Vulnerability and Lipid Core Burden Assessed by Near-Infrared Spectroscopy-Intravascular Ultrasound in a Fresh Cadaver,
第86回日本循環器学会学術集会, Mar. 2022. Tomonori Takahasi, Kenya Kusunose, Yukina Hirata, Susumu Nisio, Yuichiro Okushi, Hiromitsu Seno, Y Saijo, Muneyuki Kadota, Yutaka Kawabata, Tomomi Matsuura, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Cardiovascular Risk Factors Associated with Left Ventricular Strain Distribution in Patients without Known Cardiovascular Disease,
第86回日本循環器学会学術集会, Mar. 2022. 西條良仁, 佐村高明, 高橋智子, 大櫛祐一郎, 瀬野弘光, 高橋智紀, 門田宗之, 川端豊, 松浦朋美, 伊勢孝之, 楠瀬賢也, 山口浩司, 八木秀介, 山田博胤, 添木武, 若槻哲三, 秦広樹, 佐田政隆 :
滲出性収縮性心膜炎の1例,
第119回日本循環器学会四国地方会, 2021年12月. 數藤久美子, 福田大受, 伊勢孝之, 楠瀬賢也, 山口浩司, 八木秀介, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
マクロファージ特異的DNaseII欠損が動脈硬化に与える影響,
第119回日本循環器学会四国地方会, 2021年12月. 大櫛祐一郎, 楠瀬賢也, 西條良仁, 山口浩司, 八木秀介, 福田大受, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
心エコー検査によるがん治療関連心筋障害サーベイランスの有効性,
第119回日本循環器学会四国地方会, 2021年12月. 川端豊, 若槻哲三, 山口浩司, 門田宗之, 伊勢孝之, 楠瀬賢也, 松浦朋美, 八木秀介, 福田大受, 山田博胤, 添木武, 佐田政隆 :
冠動脈塞栓症を発症した2症例の臨床的検討,
第69回日本心臓病学会学術集会, 2021年9月. 伊勢孝之, 川端豊, 高橋智紀, 山口浩司, 福田大受, 若槻哲三, 佐村高明, 藤本鋭貴, 秦広樹, 佐田政隆 :
アクセス困難症例に対し，右鎖骨下動脈アプローチでTAVI施行した1例,
第27回日本心血管インターベンション治療学会(CVIT)中国四国地方会, 2021年9月. 川端豊, 若槻哲三, 山口浩司, 高橋智紀, 伊勢孝之, 福田大受, 佐田政隆 :
回旋枝入口部線維製性プラークに対してOASを用いstentess PCIを施行で来た1例,
第27回日本心血管インターベンション治療学会(CVIT)中国四国地方会, 2021年9月. 伊勢孝之, 川端豊, 高橋智紀, 山口浩司, 福田大受, 若槻哲三, 佐田政隆 :
Withコロナに対した心臓カテーテルオンライン臨床実習システムの構築,
第27回日本心血管インターベンション治療学会(CVIT)中国四国地方会, 2021年9月. 吉田知哉, 瀬野弘光, 松本和久, 松浦朋美, 西條良仁, 門田宗之, 川端豊, 楠瀬賢也, 伊勢孝之, 添木武, 山口浩司, 八木秀介, 山田博胤, 若槻哲三, 多田恵曜, 佐田政隆 :
ペースメーカー植え込み後に発覚した側頭葉てんかんによる発作性心静止の一例,
第263回徳島医学会学術集会, 2021年8月. Tserensonom Munkhtsetseg, 八木秀介, 伊勢孝之, 門田宗之, 川端豊, 西條良仁, 松浦朋美, 楠瀬賢也, 山口浩司, 福田大受, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
動脈硬化性疾患の高リスク患者において大動脈弁の石灰化と血清リポ蛋白との関連,
第263回徳島医学会学術集会, 2021年8月. 手束一貴, 高橋智紀, 西條良仁, 川端豊, 門田宗之, 松浦朋美, 伊勢孝之, 山口浩司, 八木秀介, 福田大受, 山田博胤, 添木武, 若槻哲三, 佐村高明, 秦広樹, 佐田政隆 :
ポスタ-セッション左冠動脈主幹部の急性冠症候群の2症例,
第263回徳島医学会学術集会(令和3年度夏期), 2021年8月. 伊勢孝之, 門田宗之, 川端豊, 楠瀬賢也, 山口浩司, 八木秀介, 福田大受, 山田博胤, 添木武, 若槻哲三, 佐村高明, 藤本鋭貴, 秦広樹, 佐田政隆 :
合同シンポジウムカテ-テル大動脈弁置換術(TAVI)によって激変した大動脈弁狭窄症治療,
第263回徳島医学会学術集会(令和3年度夏期), 2021年8月. 伊勢孝之, 川端豊, 高橋智紀, 山口浩司, 福田大受, 若槻哲三, 佐村高明, 藤本鋭貴, 秦広樹, 佐田政隆 :
TAVI術中に上行大動脈解離を合併し，PCIと自己拡張型TAVI弁留置によってbailoutできた症例,
第27回日本心血管インターベンション治療学会(CVIT)中国四国地方会, 2021年8月. 添木武, 福田大受, 松浦朋美, 飛梅威, 伊勢孝之, 楠瀬賢也, 山口浩司, 八木秀介, 山田博胤, 若槻哲三, 佐田政隆 :
Toll-Like Receptor 9 Is a Novel Therapeutic Target to Prevent Atrial Fibrillation,
JHRS2021 第67回日本不整脈心電学会学術大会, 2021年7月. 瀬野弘光, 山口浩司, 楠瀬賢也, 山田博胤, 若槻哲三, 添木武, 佐田政隆, 佐村高明, 秦広樹, 大豆本圭 :
広範な心嚢腔内進展を認めた心臓腫瘍の一例,
第116回第118回日本循環器学会中国・四国合同地方会, 2021年6月. 谷彰浩, 八木秀介, 門田宗之, 川端豊, 松浦朋美, 楠瀬賢也, 伊勢孝之, 飛梅威, 山口浩司, 福田大受, 山田博胤, 若槻哲三, 佐田政隆 :
肺動脈性肺高血圧症に対する静注プロスタグランジン投与で高心拍出を呈した症例,
第116回第118回日本循環器学会中国・四国合同地方会, 2021年6月. 大櫛祐一郎, 楠瀬賢也, 伊勢孝之, 山口浩司, 八木秀介, 福田大受, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
ループ利尿薬使用下における心保護薬併用療法の有用性,
第116回第118回日本循環器学会中国・四国合同地方会, 2021年6月. 瀬野弘光, 松本和久, 松浦朋美, 飛梅威, 添木武, 山口浩司, 八木秀介, 山田博胤, 若槻哲三, 佐田政隆 :
ペースメーカー植込み後にj発覚した側頭葉てんかんによる発作性心静止の1例,
第124回日本内科学会四国地方会, 2021年5月. Koji Yamaguchi, Tetsuzo Wakatsuki, Yuichiroh Ohkushi, Kumiko Suto, 松本和久, Tomonori Takahashi, Muneyuki Kadota, Yutaka Kawabata, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Takeshi Tobiume, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Early and Chronic Phased Local Coagulative Responses Following Bioresorbable-polymer Drug-eluting Stent Implantation,
第85回日本循環器学会学術集会, Mar. 2021. Yutaka Kawabata, Tetsuzo Wakatsuki, Koji Yamaguchi, Daiju Fukuda, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Takeshi Tobiume, Shusuke Yagi, Hirotsugu Yamada, 添木武 and Masataka Sata :
Relationship between Coronary Intraplaque Microluminal Structure and Epicardial Adipose Tissue and Plaque Formation -A Fresh Cadaveric Study-,
第85回日本循環器学会学術集会, Mar. 2021. Yukina Hirata, Kenya Kusunose, 辻拓将, 藤森康平, YAMAGUCHI Natsumi, Sae Morita, Susumu Nishio, Yuichiroh Ohkushi, Hiromitsu Seno, 高橋智紀, Takayuki Ise, 飛梅威, Koji Yamaguchi, Daiju Fukuda, Shusuke Yagi, Hirotsugu Yamada, 添木武, Tetsuzo Wakatsuki, 古徳純一 and Masataka Sata :
Deep Learning for Detection of Elevated Pulmonary Artery Wedge Pressure Using Standard Chest X-Ray,
第85回日本循環器学会学術集会, Mar. 2021. 川端豊, 若槻哲三, 山口浩司, 福田大受, 伊藤浩敬, 伊勢孝之, 楠瀬賢也, 松浦朋美, 飛梅威, 八木秀介, 山田博胤, 添木武, 佐田政隆 :
光干渉断層法で観察される冠動脈壁微小管腔構造と局所冠動脈周囲脂肪内炎症および冠動脈プラークの関連 -未固定遺体における検討-,
Beyond Angiography Japan XXV, 2021年3月. 山田拓哉, 谷彰浩, 門田宗之, 伊勢孝之, 川端豊, 松浦朋美, 楠瀬賢也, 飛梅威, 山口浩司, 八木秀介, 福田大受, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
大動脈四尖弁に対してTAVIを施行した一症例,
第262回徳島医師学会学術集会, 2021年3月. ムギー (名), 八木秀介, 門田宗之, 川端豊, 松本和久, 楠瀬賢也, 山口浩司, 飛梅威, 松浦朋美, 福田大受, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
当院におけるイバブラジンの使用経験,
第262回徳島医師学会学術集会, 2021年3月. 平田有紀奈, 楠瀬賢也, 辻拓将, 藤森康平, 山口夏美, 森田沙瑛, 西尾進, 大櫛祐一郎, 瀬野弘光, 高橋智紀, 伊勢孝之, 飛梅威, 山口浩司, 福田大受, 八木秀介, 山田博胤, 添木武, 若槻哲三, 古徳純一, 佐田政隆 :
ディープラーニングによる胸部X-pを用いた肺動脈圧上昇の検出,
第85回日本循環器学会学術集会, 2021年3月. Muneyuki Kadota, Shusuke Yagi, Takayuki Ise, Yutaka Kawabata, Tomomi Matsuura, Kenya Kusunose, Takeshi Tobiume, Koji Yamaguchi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Acute Hormonal Effect of the Angiotensin Receptor-Neprilysin Inhibitor in Patients with Chronic Heart Failure,
第85回日本循環器学会学術集会, Mar. 2021. Koji Yamaguchi, Tetsuzo Wakatsuki, Tomonori Takahashi, R Ueno, Yutaka Kawabata, Takayuki Ise, Takeshi Tobiume and Masataka Sata :
Suppressed local coagulative response after newer-generation ultrathin strut SES implantation compared to older-generation SES implantation,
第29回日本心血管インターベンション治療学会, Feb. 2021. Koji Yamaguchi, Tetsuzo Wakatsuki, Yuichiroh Ohkushi, Kumiko Sutou, Kazuhisa Matsumoto, Tomonori Takahashi, Muneyuki Kadota, 上野理絵, Yutaka Kawabata, Tomomi Matsura, Takayuki Ise, Kenya Kusunose, Takeshi Tobiume, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
The Effect of Lower Strut Thickness and Faster Polymer Resorption on Chronic Local Coagulative Response after Drug Eluting Stent Implantation,
第84回日本循環器学会学術集会, Jul. 2020. 門田宗之, 楠瀬賢也, 伊勢孝之, 髙橋智紀, 藤本裕太, 大櫛祐一郎, 數藤久美子, 松本和久, 上野理絵, 川端豊, 山田なお, 松浦朋美, 飛梅威, 山口浩司, 八木秀介, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
ドブダミン負荷下での血行動態評価を行った潜在性閉塞性肥大型心筋症2症例の検討,
第115回日本循環器学会四国地方会, 2019年12月. 山口浩司, 若槻哲三, 松本和久, 髙橋智紀, 上野理絵, 川端豊, 松浦朋美, 楠瀬賢也, 飛梅威, 伊勢孝之, 八木秀介, 山田博胤, 添木武, 佐田政隆 :
クライオバルーンアブレーション後の肺静脈狭窄に対するDrug coated balloonの使用経験,
第115回日本循環器学会四国地方会, 2019年12月. 山口浩司, 若槻哲三, 松本和久, 髙橋智紀, 上野理絵, 川端豊, 松浦朋美, 楠瀬賢也, 伊勢孝之, 飛梅威, 八木秀介, 山田博胤, 添木武, 佐田政隆 :
新規病変に対するDrug coated balloonの効果―局所血管反応と臨床成績について―,
第115回日本循環器学会四国地方会, 2019年12月. 髙橋智子, 松浦朋美, 松本和久, 坂東左知子, 飛梅威, 山口浩司, 添木武, 若槻哲三, 佐田政隆 :
クライオバルーンアブレーション後にきたした高度肺静脈狭窄に対してDrugcoated balloon を用いて治療を行った1 例,
カテーテルアブレーション関連秋季大会2019, 2019年11月. Yutaka Kawabata, Tetsuzo Wakatsuki, Koji Yamaguchi, Hiroyuki Ito, Ueno Rie, Takayuki Ise, Todoroki Takashi, Takeshi Tobiume and Masataka Sata :
Relationship between coronary intraplaque microluminal structures and local inflammation in adjacent epicardial adipose tissue - A fresh cadaveric study,
第28回日本心血管インターベンション治療学会, Sep. 2019. 山口浩司, 若槻哲三, 髙橋智紀, 上野理絵, 川端豊, 伊勢孝之, 飛梅威, 佐田政隆 :
アブレーション後に生じた肺静脈狭窄症に対するdrug coated balloonの使用経験,
第28回日本心血管インターベンション治療学会, 2019年9月. 山口浩司, 若槻哲三, 川端豊, 山田なお, 楠瀬賢也, 伊勢孝之, 八木秀介, 山田博胤, 添木武, 佐田政隆 :
Optical coherence omographyにより器質化血栓の存在が疑われた肺癌術後急性冠症候群の1例,
第67回日本心臓病学会学術集会, 2019年9月. 山口浩司, 若槻哲三, 髙橋智紀, 上野理絵, 川端豊, 伊勢孝之, 飛梅威, 佐田政隆 :
腎不全合併虚血肢患者に対するminimum-contrast下肢血管形成術の取り組みについて,
第26回日本心血管インターベンション治療学会中国・四国地方会, 2019年9月. 川端豊, 若槻哲三, 山口浩司, 伊勢孝之, 髙橋智紀, 上野理絵, 飛梅威, 佐田政隆 :
単冠動脈症合併重症大動脈弁狭窄症に対してTAVIを施行した1例,
第26回日本心血管インターベンション治療学会中国・四国地方会, 2019年9月. 木田貴弘, 飛梅威, 松本和久, 坂東左知子, 松浦朋美, 添木武, 志村拓哉, 髙橋智子, 谷彰浩, 藤本裕太, 大櫛祐一郎, 數藤久美子, 髙橋智紀, 上野理絵, 門田宗之, 川端豊, 坂東美佳, 山田なお, 伊藤浩敬, 伊勢孝之, 楠瀬賢也, 山口浩司, 八木秀介, 福田大受, 山田博胤, 若槻哲三, 佐田政隆 :
房室ブロックの進行に伴い明らかになり，恒久的ペースメーカー植込み術後のファーフィールドR波センシングへの関与が疑われた束枝心室間副伝導路の1例,
第259回徳島医学会学術集会, 2019年8月. 井口裕貴, 飛梅威, 松本和久, 坂東左知子, 松浦朋美, 添木武, 志村拓哉, 髙橋智子, 谷彰浩, 藤本裕太, 大櫛祐一郎, 數藤久美子, 髙橋智紀, 上野理絵, 門田宗之, 川端豊, 坂東美佳, 山田なお, 伊藤浩敬, 伊勢孝之, 楠瀬賢也, 山口浩司, 八木秀介, 福田大受, 山田博胤, 若槻哲三, 佐田政隆 :
房室ブロックの予防に順行性速伝導路と順行性遅伝導路のマッピングが有用であった順行性速伝導路の下方偏位を伴う遅速型房室結節リエントリー性頻拍の1例,
第259回徳島医学会学術集会, 2019年8月. Gulinu Maimaituxun, Daiju Fukuda, Shusuke Yagi, Yukina Hirata, Takashi Iwase, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Koji Yamaguchi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Masataka Sata and Michio Shimabukuro :
Gender specific impact of epicardial adipose tissue thickness on coronary artery disease,
第19回日本抗加齢医学会総会, Jun. 2019. 數藤久美子, 楠瀬賢也, 松浦朋美, 山田なお, 松本和久, 上野理絵, 川端豊, 伊勢孝之, 飛梅威, 山口浩司, 八木秀介, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
進行性心不全を呈す抗ミトコンドリア抗体陽性筋炎の症例,
第114回日本循環器学会中国・四国合同地方会, 2019年6月. 谷彰浩, 楠瀬賢也, 松本和久, 松浦朋美, 伊勢孝之, 飛梅威, 山口浩司, 八木秀介, 福田大受, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
拡張期僧帽弁逆流の治療適応判断に心房心室同時ペーシングが有効であった1例,
第114回日本循環器学会中国・四国合同地方会, 2019年6月. 志村拓哉, 伊勢孝之, 川端豊, 藤本裕太, 松本和久, 上野理絵, 山田なお, 伊藤浩敬, 松浦朋美, 楠瀬賢也, 山口浩司, 八木秀介, 福田大受, 山田博胤, 添木武, 若槻哲三, 黒部裕嗣, 藤本鋭貴, 佐田政隆 :
先天性二尖弁に対するTAVIの2例,
第114回日本循環器学会中国・四国合同地方会, 2019年6月. 大池由夏, 飛梅威, 松本和久, 山田なお, 坂東左知子, 松浦朋美, 伊勢孝之, 楠瀬賢也, 山口浩司, 若槻哲三, 添木武, 山田博胤, 佐田政隆 :
His束より上方レベルの心房刺激でのみ誘発可能であった房室結節リエントリー性頻拍の1例,
第114回日本循環器学会中国・四国合同地方会, 2019年6月. 中村昌史, 川端豊, 伊勢孝之, 藤本裕太, 原田貴文, 松本和久, 西條良仁, 上野理絵, 山田なお, 伊藤浩敬, 轟貴史, 楠瀬賢也, 飛梅威, 山口浩司, 福田大受, 八木秀介, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
経食道心エコーガイド下の経皮的腫瘍生検により早期に診断し得た心臓原発血管肉腫の一例,
第114回日本循環器学会中国・四国合同地方会, 2019年6月. 松本力三, 鳥居裕太, 若槻哲三, 西尾進, 湯浅麻美, 平田有紀奈, 山尾雅美, 楠瀬賢也, 山田博胤, 佐田政隆 :
右大腿動静脈瘻修復術後に繰り返し生じた深部静脈血栓症の1例,
第114回日本循環器学会中国・四国合同地方会, 2019年6月. Gulinu Maimaituxun, Daiju Fukuda, Shusuke Yagi, Tsukasa Iwase, Kenya Kusunose, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Masataka Sata and Michio Shimabukuro :
Type 2 diabetes but not apicardial adipose tissue thickness is a predictor for coronary artery diseases in women,
第62回日本糖尿病学会年次学術集会, May 2019. Gulinu Maimaituxun, Daiju Fukuda, Shusuke Yagi, Yukina Hirata, T Iwase, S Takao, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Takeshi Tobiume, Koji Yamaguchi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Masafumi Harada, Masataka Sata and Michio Shimabukuro :
Kidney fat and its impact on coronary artery disease,
第4回日本血管不全学会学術集会・総会, Apr. 2019. Gulinu Maimaituxun, Daiju Fukuda, Shusuke Yagi, Yukina Hirata, T Iwase, S Takao, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Takeshi Tobiume, Koji Yamaguchi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Masafumi Harada, Masataka Sata and Michio Shimabukuro :
Peri-renal fat volume is negatively associated with the adiponectin expression in human,
第4回日本血管不全学会学術集会・総会, Apr. 2019. 伊藤浩敬, 若槻哲三, 山口浩司, 福田大受, 川端豊, 轟貴史, 松浦朋美, 伊勢孝之, 楠瀬賢也, 飛梅威, 八木秀介, 山田博胤, 添木武, 佐田政隆 :
Microluminal structures of coronary plaque and vasa vasorums affect coronary inflammation: A fresh cadaveric studys,
第83回日本循環器学会学術集会, 2019年3月. 添木武, 松浦朋美, 福田大受, 松本和久, 飛梅威, 楠瀬賢也, 山田博胤, 若槻哲三, 佐田政隆 :
The Factor Xa Inhibitor, Edoxaban, Prevents Cardiac Remodeling in Rats with Myocardial Infarction,
第83回日本循環器学会学術集会, 2019年3月. 川端豊, 若槻哲三, 山口浩司, 伊藤浩敬, 福田大受, 轟貴史, 松浦朋美, 伊勢孝之, 楠瀬賢也, 飛梅威, 八木秀介, 山田博胤, 添木武, 佐田政隆 :
Coronary intraplaque microluminal structure are associated with the quality and quantity of epicardial adipose tissue -A fresh cadaveric stury-,
第83回日本循環器学会学術集会, 2019年3月. 藤本裕太, 楠瀬賢也, 西條良仁, Robert Zheng, 原田貴文, 松本和久, 上野理絵, 川端豊, 山田なお, 伊藤浩敬, 轟貴史, 伊勢孝之, 飛梅威, 山口浩司, 八木秀介, 添木武, 山田博胤, 添木武, 若槻哲三, 黒部裕嗣, 佐田政隆 :
Staphylococcus による感染性内膜炎の一例,
第113回日本循環器学会四国合同地方会, 2018年12月. Robert Zheng, 伊勢孝之, 川端豊, 八木秀介, 西條良仁, 上野理絵, 坂東美佳, 伊藤浩敬, 轟貴史, 松浦朋美, 楠瀬賢也, 飛梅威, 山口浩司, 福田大受, 山田博胤, 添木武, 若槻哲三, 黒部裕嗣, 藤本鋭貴, 北川哲也, 佐田政隆 :
Single coronary 合併重症ASに対してTAVIを施行し救命し得た1例,
第113回日本循環器学会四国合同地方会, 2018年12月. 川端豊, 若槻哲三, 山口浩司, 伊藤浩敬, 楠瀬賢也, 松浦朋美, 轟貴史, 飛梅威, 八木秀介, 山田博胤, 添木武, 佐田政隆 :
未固定遺体において光干渉断層法で観察される冠動脈壁微小管腔構造と局所周囲脂肪炎症との関連,
第66回日本心臓病学会学術集会, 2018年9月. 伊藤浩敬, 若槻哲三, 山口浩司, 福田大受, 川端豊, 伊勢孝之, 楠瀬賢也, 松浦朋美, 轟貴史, 飛梅威, 八木秀介, 山田博胤, 添木武, 佐田政隆 :
未固定遺体における冠動脈壁小管腔構造と局所心臓周囲脂肪内炎症との関連,
第66回日本心臓病学会学術集会, 2018年9月. Yukina Hirata, Hirotsugu Yamada, Kenya Kusunose, Susumu Nishio, Hrada Osamu, Miyasato Naomi, Hrakuni Atsusi, Ito Nobuhiko, Koji Yamaguchi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Echocardiographic Evaluation of Epicardial Adipose Tissue Thickness in Patients with Coronary Artery Disease: A Multicenter Study,
第66回日本心臓病学会学術集会, Sep. 2018. 山口浩司, 若槻哲三, 西條良仁, 上野理絵, 川端豊, 坂東美佳, 伊藤浩敬, 轟貴史, 松浦朋美, 伊勢孝之, 楠瀬賢也, 飛梅威, 八木秀介, 山田博胤, 添木武, 佐田政隆 :
第三世代薬剤溶出性ステント留置後における局所凝固反応塗装ステント長の関連性,
第66回日本心臓病学会学術集会, 2018年9月. 平田有紀奈, 楠瀬賢也, 山田博胤, 鳥居裕太, 西尾進, 西條良仁, 坂東美佳, 伊勢孝之, 山口浩司, 添木武, 若槻哲三, 佐田政隆 :
過度に蓄積した心外膜下脂肪は薬剤溶出型ステント留置後の再狭窄を予測するマーカーとなる,
第66回日本心臓病学会学術集会, 2018年9月. 福田大受, 山口浩司, 楠瀬賢也, 八木秀介, 山田博胤, 若槻哲三, 添木武, 佐田政隆 :
活性型血液凝固第X因子が冠動脈硬化に与える影響,
第66回日本心臓病学会学術集会, 2018年9月. 轟貴史, 若槻哲三, 山口浩司, 數藤久美子, 原田貴文, 上野理絵, 西條良仁, 川端豊, 伊藤浩敬, 伊勢孝之, 飛梅威, 佐田政隆 :
ステント遠位部狭窄病変の関与が疑われた2枝同時発症の超遅発性ステント血栓症の1例,
第25回日本心血管インターベーション治療学会(CVIT)中国・四国地方会, 2018年9月. 川端豊, 若槻哲三, 山口浩司, 伊藤浩敬, 上野理絵, 伊勢孝之, 轟貴史, 飛梅威, 佐田政隆 :
光干渉断層法で観察される冠動脈壁微小管腔構造と局所周囲脂肪炎症との関連-未固定遺体における検討-,
第25回日本心血管インターベーション治療学会(CVIT)中国・四国地方会, 2018年9月. 伊藤浩敬, 添木武, 松浦朋美, 伊勢孝之, 楠瀬賢也, 飛梅威, 山口浩司, 八木秀介, 山田博胤, 若槻哲三, 佐田政隆 :
AVNRTアブレーション治療後に発生したJunctional Tachycardiaの1例,
第112回日本循環器学会中国・四国合同地方会, 2018年6月. 轟貴史, 若槻哲三, 山口浩司, 瀬野弘光, 數藤久美子, 西條良仁, 川端豊, 上野理絵, 伊藤浩敬, 松浦朋美, 楠瀬賢也, 伊勢孝之, 飛梅威, 八木秀介, 福田大受, 山田博胤, 添木武, 佐田政隆 :
EES留置3年後，術前に抗血小板剤中止しペパリン置換したにもかかわらず2枝同時ステント閉塞を起こした1例,
第112回日本循環器学会中国・四国合同地方会, 2018年6月. 清水郁子, 瀬野弘光, 楠瀬賢也, 山口浩司, 山田博胤, 若槻哲三, 添木武, 岩瀬俊, 黒部裕嗣, 北川哲也, 佐田政隆 :
一年の経過で急速に進行したCalcified Amorphous Tumor(CAT)に対し腫瘍摘出手術を行った一例,
第112回日本循環器学会中国・四国合同地方会, 2018年6月. Robert Zheng, 數藤久美子, 楠瀬賢也, 松浦朋美, 瀬野弘光, 西條良仁, 上野理絵, 川端豊, 坂東美佳, 伊藤浩敬, 轟貴史, 伊勢孝之, 飛梅威, 山口浩司, 八木秀介, 福田大受, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
薬物治療が著効したSLE関連心筋炎の一例,
第112回日本循環器学会中国・四国合同地方会, 2018年6月. 西條良仁, 楠瀬賢也, 山田博胤, 西尾進, 瀬野弘光, 數藤久美子, 川端豊, 上野理絵, 伊藤浩敬, 轟貴史, 松浦朋美, 伊勢孝之, 飛梅威, 山口浩司, 八木秀介, 添木武, 若槻哲三, 佐田政隆 :
アトラサイクリン系抗癌剤による心筋障害の局在性および化学療法関連心筋障害との関連の検討,
第112回日本循環器学会中国・四国合同地方会, 2018年6月. 西尾進, 楠瀬賢也, 平田有紀奈, 鳥居裕太, 天野里江, 山尾雅美, 伊藤浩敬, 伊勢孝之, 山口浩司, 若槻哲三, 山田博胤, 佐田政隆 :
左上肢の脱力で脳卒中センターへ搬送された急性冠症候群の1例,
超音波検査技術, Vol.43, No.3, 363, 2018年6月. Kenya Kusunose, Yoshihito Saijoh, Koji Yamaguchi, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Right Ventricular Function Predicts Beneficial Effects of Cardiac Rehabilitation in Patients with Chronic Heart Failure,
第82回日本循環器学会, Mar. 2018. Yoshihito Saijoh, Kenya Kusunose, Hirotsugu Yamada, Susumu Nishio, Yukina Hirata, Yuta Torii, Kumiko Sutou, 上野理絵, Yutaka Kawabata, Hiroyuki Itou, Takafumi Todoroki, Tomomi Matsuura, Takayuki Ise, Takeshi Tobiume, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Anthracyclines induce early changes in localized left ventricular dysfunction.,
第82回日本循環器学会, Mar. 2018. Takeshi Soeki, Tomomi Matsuura, Daiju Fukuda, Takeshi Tobiume, Kenya Kusunose, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Hirotsugu Yamada, Tetsuzo Wakatsuki and Masataka Sata :
C-type natriuretic peptide improves left ventricular diastolic dysfunction in HFpEF model rats.,
第82回日本循環器学会, Mar. 2018. Yutaka Kawabata, Takeshi Soeki, Takayuki Ise, Tomomi Matsuura, Yoshihito Saijoh, Takeshi Tobiume, Shusuke Yagi, Koji Yamaguchi, Hirotsugu Yamada, Tetsuzo Wakatsuki and Masataka Sata :
Effects of L-/N-type Calcium Channel Blocker on Proteinuria and Angiotensin -renin Feedback in Hypertensive Patients,
第82回日本循環器学会, Mar. 2018. Takayuki Ise, Shusuke Yagi, Yutaka Kawabata, Seno Hiromitsu, Kumiko Sutou, Yoshihito Saijoh, Rie Ueno, Hiroyuki Ito, Takafumi Todoroki, Tomomi Matsuura, Kenya Kusunose, Takeshi Tobiume, Koji Yamaguchi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Acute Hemodynamic Effect of Handgrip Stress in Patients with Chronic Heart Failure.,
第82回日本循環器学会, Mar. 2018. Yukina Hirata, Kenya Kusunose, Hirotsugu Yamada, Yuta Torii, Susumu Nishio, Hiromitsu Seno, Tomomi Matsuura, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Impact of Marathon Running on Left Atrial function in healthy trained volunteers,
第82回日本循環器学会, Mar. 2018. Koji Yamaguchi, Tetsuzo Wakatsuki, Yutaka Kawabata, Hiroyuki Itou, Takafumi Todoroki, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Takeshi Tobiume, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Differential Response of Local Coagulation after Coronary Angioplasty with Paclitaxel.,
第82回日本循環器学会, Mar. 2018. Tetsuzo Wakatsuki, Koji Yamaguchi, Daiju Fukuda, Yutaka Kawabata, 轟貴史, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Takeshi Tobiume, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Growth of vasa vasorum is associated with local inflammation around coronary plaque in fresh cadavers.,
第82回日本循環器学会, Mar. 2018. Hiroyuki Ito, Tetsuzo Wakatsuki, Koji Yamaguchi, Daiju Fukuda, Yutaka Kawabata, 轟貴史, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Takeshi Tobiume, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Growth of Vasa Vasorum is Associated with Local Inflammation around Coronary Plaque in Fresh Cadavers(和訳中),
日本循環器学会学術集会抄録集, PJ007-3, Mar. 2018. Koji Yamaguchi, Tetsuzo Wakatsuki, Yutaka Kawabata, Hiroyuki Ito, 轟貴史, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Takeshi Tobiume, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Differential Response of Local Coagulation after Coronary Angioplasty with Paclitaxel(和訳中),
日本循環器学会学術集会抄録集, PJ022-1, Mar. 2018. Yutaka Kawabata, Takeshi Soeki, Takayuki Ise, Tomomi Matsuura, Kenya Kusunose, Takeshi Tobiume, Shusuke Yagi, Koji Yamaguchi, Hirotsugu Yamada, Tetsuzo Wakatsuki and Masataka Sata :
Effects of L-/N-type Calcium Channel Blocker on Proteinuria and Angiotensin II-renin Feedback in Hypertensive Patients(和訳中),
日本循環器学会学術集会抄録集, PJ067-4, Mar. 2018. Gulinu Maimaituxun, Michio Shimabukuro, Daiju Fukuda, Shusuke Yagi, Yukina Hirata, Takashi Iwase, Shoichiro Takao, Tomomi Matsuura, Takayuki Ise, Tetsuzo Wakatsuki, Masafumi Harada and Masataka Sata :
The impact of epicardial adipose tissue thickness on left ventricular diastolic dysfunction in patients with preserved ejection fraction,
日本老年医学会四国地方会, Feb. 2018. 八木秀介, 伊勢孝之, 川端豊, 伊藤浩敬, 楠瀬賢也, 山口浩司, 山田博胤, 若槻哲三, 赤池雅史, 佐田政隆 :
経カテーテル大動脈弁植込み術を施した超高齢大動脈弁狭窄症の1例,
日本老年医学会四国地方会, 2018年2月. 志村拓哉, 西條良仁, 山口浩司, 楠瀬賢也, 山田博胤, 瀬野弘光, 數藤久美子, 上野理絵, 川端豊, 伊藤浩敬, 轟貴史, 松浦朋美, 伊勢孝之, 飛梅威, 八木秀介, 添木武, 若槻哲三, 佐田政隆 :
下肢静脈血栓症の誘因となる下肢血流障害の検討-下肢静脈造影での検討-,
第111回日本循環器学会四国地方会, 2017年12月. 豊田直人, 轟貴史, 添木武, 瀬野弘光, 數藤久美子, 西條良仁, 上野理絵, 川端豊, 伊藤浩敬, 松浦朋美, 伊勢孝之, 楠瀬賢也, 飛梅威, 山口浩司, 福田大受, 八木秀介, 山田博胤, 若槻哲三, 佐田政隆 :
診断から40年後に治療しえた著明なBroad Kent束を有するWPW症候群の一例,
第111回日本循環器学会四国地方会, 2017年12月. 中野睦基, 川端豊, 添木武, 松浦朋美, 飛梅威, 瀬野弘光, 數藤久美子, 西條良仁, 上野理絵, 伊藤浩敬, 轟貴史, 楠瀬賢也, 伊勢孝之, 山口浩司, 八木秀介, 山田博胤, 若槻哲三, 佐田政隆 :
嚥下性失神に対して高級性ペースメーカー植え込み術が有効であった1例,
第111回日本循環器学会四国地方会, 2017年12月. 矢野哲弘, 松浦朋美, 數藤久美子, 瀬野弘光, 西條良仁, 上野理絵, 川端豊, 伊藤浩敬, 轟貴史, 伊勢孝之, 楠瀬賢也, 飛梅威, 山口浩司, 八木秀介, 福田大受, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
心房細動アブレーション後の医原性心房中隔欠損残存により右心不全症状をきたした一例,
第111回日本循環器学会四国地方会, 2017年12月. 川端豊, 若槻哲三, 山口浩司, 伊藤浩敬, 福田大受, 伊勢孝之, 楠瀬賢也, 松浦朋美, 轟貴史, 廣野明, 飛梅威, 八木秀介, 山田博胤, 添木武, 佐田政隆 :
未固定遺体における管脈プラーク性状と局所周囲脂肪内炎症物質との関連,
第65回日本心臓病学会学術集会, 2017年9月. 山口浩司, 若槻哲三, 川端豊, 伊藤浩敬, 轟貴史, 松浦朋美, 楠瀬賢也, 飛梅威, 伊勢孝之, 八木秀介, 山田博胤, 添木武, 佐田政隆 :
Biodegradable polymer SESの慢性期局所血管反応の検討-Durable polymer SESとの比較-,
第65回日本心臓病学会学術集会, 2017年9月. 西條良仁, 楠瀬賢也, 山田博胤, 瀬野弘光, 西尾進, 伊藤浩敬, 轟貴史, 伊勢孝之, 松浦朋美, 飛梅威, 山口浩司, 八木秀介, 若槻哲三, 佐田政隆 :
経食道心エコー図検査の再検によりvegetationを同定しえた感染性心内膜炎の一例,
第65回日本心臓病学会学術集会, 2017年9月. 轟貴史, 八木秀介, 楠瀬賢也, 伊勢孝之, 西條良仁, 瀬野弘光, 廣野明, 松浦朋美, 福田大受, 山口浩司, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
膠原病患者での肺動脈楔入圧と左室拡張期末期圧の関係,
第65回日本心臓病学会学術集会, 2017年9月. 若槻哲三, 山口浩司, 福田大受, 川端豊, 伊藤浩敬, 伊勢孝之, 楠瀬賢也, 八木秀介, 山田博胤, 添木武, 佐田政隆 :
微小管腔構造を認める冠動脈壁の組織性状の評価-未固定遺体における検討-,
第65回日本心臓病学会学術集会, 2017年9月. Kenya Kusunose, Hirotsugu Yamada, Susumu Nishio, Yuta Torii, Yukina Hirata, Hiromitsu Seno, Yoshihito Saijoh, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Preload Stress Echocardiography Predicts Outcomes in Patients with Pre-served Ejection Fraction and Low Gradient Aortic Stenosis,
第65回日本心臓病学会学術集会, Sep. 2017. 山口浩司, 若槻哲三, 川端豊, 伊藤浩敬, 轟貴史, 伊勢孝之, 飛梅威, 佐田政隆 :
OPTIMOカテーテル使用後に生じた巨大血管解離の1例,
第24回日本心血管インターベーション治療学会中国・四国地方会, 2017年9月. 轟貴史, 若槻哲三, 山口浩司, 川端豊, 伊藤浩敬, 伊勢孝之, 廣野明, 飛梅威, 佐田政隆 :
局所的な右腎動脈狭窄を認め血管内超音波を併用し経皮的腎動脈形成術を施行した繊維筋性異形成症の1症例,
第24回日本心血管インターベーション治療学会中国・四国地方会, 2017年9月. 川端豊, 若槻哲三, 山口浩司, 伊藤浩敬, 伊勢孝之, 轟貴史, 飛梅威, 佐田政隆 :
SES留置遠隔期に再狭窄とPSSを同時に認めた病変に対するDCB治療の効果の検討-局所凝固反応の観点から-,
第24回日本心血管インターベーション治療学会中国・四国地方会, 2017年9月. 荒瀬美晴, 飛梅威, 伊藤浩敬, 松浦朋美, 添木武, 瀬野弘光, 西條良仁, 川端豊, 轟貴史, 伊勢孝之, 楠瀬賢也, 山口浩司, 八木秀介, 山田博胤, 若槻哲三, 佐田政隆 :
薬物療法の継続が困難で頻脈誘発性心筋症を生じたが，カテーテルアブレーションにて合併症なく根治に成功した洞房リエントリー性頻拍の1例,
第255回徳島医学会学術集会, 2017年8月. Hiroyuki Ito, Tetsuzo Wakatsuki, Koji Yamaguchi, Yutaka Kawabata, Akira Hirono, Takafumi Todoroki, Takayuki Ise, Takeshi Tobiume and Masataka Sata :
The relationship between coronary plaque characteristics and local inflammation in adjacent epicardial adipose tissue in fresh cadaveric models,
第26回日本心血管インターベンション治療学会学術集会:京都, Jul. 2017. Yutaka Kawabata, Tetsuzo Wakatsuki, Koji Yamaguchi, 伊藤浩敬, Takayuki Ise, Akira Hirono, Takafumi Todoroki, Takeshi Tobiume and Masataka Sata :
A first assessment of coronary plaque characteristics, adjacent epivascular adipose tissue, and histopathological findings in fresh cadaveric model-a case report-,
第26回日本心血管インターベンション治療学会学術集会:京都, Jul. 2017. 瀬野弘光, 添木武, 松浦朋美, 伊勢孝之, 楠瀬賢也, 山口浩司, 山田博胤, 若槻哲三, 佐田政隆 :
計算負荷試験で誘発された心室性期外収縮の一例,
第110回日本循環器学会中国・四国合同地方会, 2017年6月. 伊藤浩敬, 飛梅威, 添木武, 大櫛祐一郎, 瀬野弘光, 西條良仁, 川端豊, 轟貴史, 廣野明, 松浦朋美, 楠瀬賢也, 伊勢孝之, 山口浩司, 八木秀介, 山田博胤, 若槻哲三, 佐田政隆 :
左鎖骨下への植え込み型除細動器植え替え後に生じたTwiddler症候群の1例,
第110回日本循環器学会中国・四国合同地方会, 2017年6月. 川端豊, 伊勢孝之, 山口浩司, 若槻哲三, 楠瀬賢也, 松浦朋美, 八木秀介, 飛梅威, 山田博胤, 添木武, 川谷洋平, 荒瀬裕己, 黒部裕嗣, 藤本鋭貴, 北川哲也, 佐田政隆 :
肺癌術前にバルーン大動脈弁形成術を施行し良好な開大が得られた重症大動脈弁狭窄症の一例,
第110回日本循環器学会中国・四国地方会, 2017年6月. 西條良仁, 山田博胤, 楠瀬賢也, 西尾進, 大櫛祐一郎, 瀬野弘光, 原知也, 川端豊, 伊藤浩敬, 轟貴史, 廣野明, 松浦朋美, 伊勢孝之, 飛梅威, 山口浩司, 八木秀介, 添木武, 若槻哲三, 黒部裕嗣, 渡邉俊介, 佐田政隆 :
著名な心内膜肥厚を認めた acromegalic cardiomyopathy の一例,
第110回日本循環器学会中国・四国地方会, 2017年6月. 楠瀬賢也, 山田博胤, 林修司, 伊勢孝之, 山口浩司, 八木秀介, 添木武, 若槻哲三, 佐田政隆 :
経食道心エコー図の再検査によりVegetationを同定しえた感染性心内膜炎の1例,
日本内科学会第116回四国地方会, 2017年5月. Hirotsugu Yamada, Kenya Kusunose, 天野里江, 西條良仁, 瀬野弘光, 西尾進, 平田有紀奈, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Effect of Sitagliptin on Left Ventricular Function in Patients with Type 2 Diabetes: A Subanalysis of the PROLOGUE Study,
第81回日本循環器学会学術集会, Mar. 2017. 西條良仁, Hirotsugu Yamada, Kenya Kusunose, 西尾進, 瀬野弘光, 大櫛祐一郎, 高木恵理, 上野理絵, 原知也, 川端豊, 斎藤友子, 伊藤浩敬, 轟貴史, Tomomi Matsuura, Takayuki Ise, Takeshi Tobiume, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Impact of Left Atrial Ischemia on Left Atrial Reservoir Function in Patients with Old Myocardial Infarction,
第81回日本循環器学会学術集会, Mar. 2017. 平田有紀奈, Kenya Kusunose, Hirotsugu Yamada, 清水陸登, 鳥居裕太, 西尾進, 瀬野弘光, 西條良仁, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Quantitative Classification of Left Atrial Appendage is Superior to Visual Classification for Risk Stratification of Stroke in Atrial Fibrillation,
第81回日本循環器学会学術集会, Mar. 2017. 轟貴史, Shusuke Yagi, Kenya Kusunose, Hirotsugu Yamada, Takayuki Ise, Tomomi Matsuura, Takeshi Tobiume, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Serum Level of Lipoprotein (a) is a Risk Factor for Aortic Valve Sclerosis in Women,
第81回日本循環器学会学術集会, Mar. 2017. 大櫛祐一郎, Hirotsugu Yamada, Kenya Kusunose, 西條良仁, 瀬野弘光, Tomomi Matsuura, Takayuki Ise, Koji Yamaguchi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Accuracy of Diagnosis of Elevated Left Atrial Pressure Using Recommendation for the Evaluation of Left Ventricular Diastolic Function by Echocardiograph,
第81回日本循環器学会学術集会, Mar. 2017. 伊勢孝之, 八木秀介, 瀬野弘光, 西條良仁, 高木恵理, 上野理絵, 原知也, 伊藤浩敬, 松浦朋美, 楠瀬賢也, 飛梅威, 山口浩司, 添木武, 若槻哲三, 佐田政隆 :
Nocturnal Hypoxemia Predicts Cardiac Events in Patients with Cardiac Risk Factors,
第81回日本循環器学会学術集会, 2017年3月. 楠瀬賢也, 山田博胤, 西尾進, 平田有紀奈, 瀬野弘光, 西條良仁, 伊勢孝之, 山口浩司, 八木秀介, 添木武, 若槻哲三, 佐田政隆 :
Right Ventricular Myocardial Strain during Preload Augmentation is Associated with Exercise Capacity in Patients with Chronic Heart Failure,
第81回日本循環器学会学術集会, 2017年3月. Maimaituxun Gulinu, Michio Shimabukuro, Koji Yamaguchi, Shusuke Yagi, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Takeshi Tobiume, Daiju Fukuda, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Local Epicardial Adipose Tissue Thickness and Its Impact on Coronary Atherosclerosis,
第81回日本循環器学会学術集会, Mar. 2017. 伊藤浩敬, 若槻哲三, 山口浩司, 福田大受, 川端豊, 轟貴史, 松浦朋美, 楠瀬賢也, 伊勢孝之, 飛梅威, 八木秀介, 山田博胤, 添木武, 佐田政隆 :
Lipid-rich Coronary Plaque is Associated with Local Inflammation in Adjacent Epicardial Adipose Tissue in Fresh Cadaveric Models,
第81回日本循環器学会学術集会, 2017年3月. Tetsuzo Wakatsuki, Koji Yamaguchi, 伊藤浩敬, Daiju Fukuda, 川端豊, 轟貴史, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Takeshi Tobiume, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
The Tissue Characteristics of Coronary Plaque with Microluminal Structures Identified by OCT Associated with Local Inflammatory Response in Fresh Cadavers,
第81回日本循環器学会学術集会, Mar. 2017. Koji Yamaguchi, Tetsuzo Wakatsuki, 伊藤浩敬, 川端豊, 轟貴史, Tomomi Matsuura, Kenya Kusunose, Takayuki Ise, Takeshi Tobiume, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Comparison of Local Coagulative Response after Coronary Angioplasty - First Generation DES vs Second Generation-DES vs Drug Coated Balloon -,
第81回日本循環器学会学術集会, Mar. 2017. 瀬野弘光, Kenya Kusunose, Hirotsugu Yamada, 西條良仁, 西尾進, 平田有紀奈, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Comparison of Right Ventricular Global Longitudinal Strain between Vender-dependent and Vender-independent Two-dimensional Speckle Tracking Software,
第81回日本循環器学会学術集会, Mar. 2017. 谷口実佑, Takeshi Soeki, Tomomi Matsuura, 佐藤裕紀, Takeshi Tobiume, 原知也, Kenya Kusunose, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Activated Factor X Signaling Pathway via Protease-Activated Receptor-2 is a Novel Therapeutic Target to Prevent Atrial Fibrillation,
第81回日本循環器学会学術集会, Mar. 2017. 上田浩之, 瀬野弘光, 伊勢孝之, 楠瀬賢也, 山口浩司, 山田博胤, 若槻哲三, 添木武, 東島潤, 佐田政隆 :
ベバシズマブ併用化学療法中に深部静脈血栓症および肺塞栓症を来した大腸癌の1例-血栓素因の検討も含めて,
第254回徳島医学会学術集会, 2017年2月. 山本清成, 轟貴史, 大櫛祐一郎, 上野理恵, 伊勢孝之, 瀬野弘光, 西條良仁, 高木恵理, 原知也, 川端豊, 斎藤友子, 伊藤浩敬, 松浦朋美, 飛梅威, 楠瀬賢也, 山口浩司, 八木秀介, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆, 門田友里, 西村正人, 苛原稔 :
PET/CTにて診断できた心サルコイドーシスの1例,
第254回徳島医学会学術集会, 2017年2月. 笠井明成, 原知也, 山田博胤, 添木武, 若槻哲三, 足立克仁, 佐田政隆 :
著明な刺激伝導系異常を呈したBecker型筋ジストロフィーの1例,
第254回徳島医学会学術集会(平成28年度冬期), 2017年2月. Maimaituxun Gulinu, Michio Shimabukuro, Daiju Fukuda, Shusuke Yagi, Yukina Hirata, Takashi Iwase, Shoichiro Takao, Tomomi Matsuura, Takayuki Ise, Tetsuzo Wakatsuki, Masafumi Harada and Masataka Sata :
The impact of epicardial adipose tissue thickness on left ventricular diastolic dysfunction in patients with preserved ejection fraction.,
Feb. 2017. Gulinu Maimaituxun, 島袋充生, 平田有紀奈, 岩瀬俊, 高尾正一郎, 松浦朋美, 伊勢孝之, 楠瀬賢也, 飛梅威, 山口浩司, 八木秀介, 福田大受, 山田博胤, 添木武, 若槻哲三, 原田雅史, 佐田政隆 :
局所心臓周囲脂肪厚の臨床的意義:冠動脈疾患での検討,
脳心血管抗加齢研究会2016, 2016年12月. 鈴木聖也, 山田博胤, 高木恵理, 高川由利子, 松浦朋美, 伊勢孝之, 平田有紀奈, 楠瀬賢也, 西條良仁, 瀬野弘光, 大櫛祐一郎, 西尾進, 山尾雅美, 鳥居裕太, 八木秀介, 山口浩司, 添木武, 若槻哲三, 佐田政隆 :
経食道心エコー検査により原因が究明された高齢発症の右心不全の1例,
第109回日本循環器学会四国地方会, 2016年12月. 高木恵理, 八木秀介, 伊勢孝之, 楠瀬賢也, 山口浩司, 山田博胤, 添木武, 若槻哲三, 佐田政隆, 高川由利子 :
右心不全の精査の過程で偶発的に見つかった冠静脈洞閉鎖および重複上大静脈の一例,
第109回日本循環器学会四国地方会, 2016年12月. 上田浩之, 瀬野弘光, 松浦朋美, 楠瀬賢也, 山口浩司, 山田博胤, 若槻哲三, 添木武, 東島潤, 佐田政隆 :
Bevacizumab併用化学療法中に深部静脈血栓症および肺塞栓症を発症した1例,
第109回日本循環器学会四国地方会, 2016年12月. 行重佐和香, 楠瀬賢也, 瀬野弘光, 西條良仁, 伊勢孝之, 八木秀介, 山口浩司, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
成人期に心不全症状を契機に発見された左室緻密化障害の一例,
第109回日本循環器学会四国地方会, 2016年12月. ロバートゼング, 西條良仁, 楠瀬賢也, 山田博胤, 轟貴史, 西尾進, 瀬野弘光, 高木恵理, 上野理絵, 原知也, 川端豊, 齋藤友子, 伊藤浩敬, 松浦朋美, 伊勢孝之, 飛梅威, 山口浩司, 八木秀介, 添木武, 若槻哲三, 佐田政隆 :
左上肢脱力を主訴に来院されたが心エコー図法を契機に急性冠症候群と診断しえた一例,
第109回日本循環器学会四国地方会, 2016年12月. 岡本恵暢, 原知也, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
重症心不全を呈したBecker型筋ジストロフィーの1家系,
日本内科学会第115回四国地方会, 2016年11月. 八木秀介, 伊勢孝之, 西川幸治, 石井亜由美, 楠瀬賢也, 山口浩司, 松浦朋美, 飛梅威, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
心不全患者に対するAdaptive servo-ventilation装着下6分間歩行における運動耐容能改善効果,
第64回日本心臓病学会学術集会, 2016年9月. 瀬野弘光, 楠瀬賢也, 山田博胤, 西條良仁, 伊勢孝之, 山口浩司, 八木秀介, 添木武, 若槻哲三, 佐田政隆 :
心血管イベント発症高リスク患者における非侵襲的血管機能検査の有用性,
第64回日本心臓病学会学術集会, 2016年9月. 添木武, 高橋甲介, 松浦朋美, 楠瀬賢也, 伊勢孝之, 飛梅威, 山口浩司, 八木秀介, 福田大受, 山田博胤, 若槻哲三, 島袋充生, 佐田政隆 :
心筋虚血再灌流障害に対する新たな治療薬としてのC型ナトリウム利尿ペプチドの可能性,
第64回日本心臓病学会学術集会, 2016年9月. 西條良仁, 楠瀬賢也, 山田博胤, 瀬野弘光, 西尾進, 伊勢孝之, 八木秀介, 山口浩司, 添木武, 若槻哲三, 佐田政隆 :
下肢陽圧負荷心エコー検査により将来の左房圧上昇を予測できるか,
第64回日本心臓病学会学術集会, 2016年9月. 伊藤浩敬, 若槻哲三, 山口浩司, 伊勢孝之, 川端豊, 上野理絵, 齋藤友子, 轟貴史, 若槻哲三, 佐田政隆 :
SES留置後超遠隔期に初めて認めたPSSを伴う再狭窄病変に対してDCB治療を施行し局所凝固反応の推移を観察した一例,
第23回日本心血管インターベンション治療学会中国・四国地方会, 2016年9月. 伊勢孝之, 若槻哲三, 山口浩司, 上野理絵, 川端豊, 齋藤友子, 伊藤浩敬, 飛梅威, 佐田政隆 :
PTSMA施行2日後に遅発性完全房室ブロックを認めた1例,
第23回日本心血管インターベンション治療学会中国・四国地方会, 2016年9月. H Ito, Tetsuzo Wakatsuki, Koji Yamaguchi, R Ueno, Y Saito, T Todoroki, Takayuki Ise, Takeshi Tobiume and Masataka Sata :
A case of trapped floppy rotawire at the distal portion of wrapped left anterior descending coronary artery,
第25回日本心血管インターベンション治療学会, Jul. 2016. Koji Yamaguchi, Tetsuzo Wakatsuki, R Ueno, H Ito, Y Saito, T Todoroki, Takayuki Ise, Takeshi Tobiume and Masataka Sata :
Suppressive Local Vascular Response after Paclitaxel Eluting Balloon Compared to Paclitaxel Eluting Stent,
第25回日本心血管インターベンション治療学会, Jul. 2016. 原知也, 福田大受, 田中君枝, 東邦康智, 平田陽一郎, 八木秀介, 山田博胤, 添木武, 若槻哲三, 島袋充生, 佐田政隆 :
活性型第X凝固因子によるマクロファージ活性化を介した新しい動脈硬化進展機序の検討,
第2回日本心血管脳卒中学会学術集会, 2016年6月. 高島啓, 尾形竜郎, 今田久美子, 若槻哲三 :
鑑別に苦慮した心房中隔死亡性腫瘍に心腔内エコーガイド下に腫瘍生検を施行した一例,
第108回日本循環器学会中国・四国合同地方会, 2016年6月. 高島啓, 尾形竜郎, 今田久美子, 若槻哲三 :
鑑別に苦慮した心房中隔脂肪性腫瘍に心腔内エコーガイド下に腫瘍生検を施行した一例,
第108回日本循環器学会中国・四国合同地方会, 2016年6月. 原知也, 山田博胤, 伊勢孝之, 楠瀬賢也, 飛梅威, 山口浩司, 八木秀介, 添木武, 若槻哲三, 佐田政隆 :
重症心不全を呈したBecker型筋ジストロフィーの1剖検例,
第108回日本循環器学会中国・四国合同地方会, 2016年6月. 原知也, 飛梅威, 伊勢孝之, 楠瀬賢也, 山口浩司, 八木秀介, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
心房細動アブレーション後に麻痺性胃拡張を来した一例,
第108回日本循環器学会中国・四国合同地方会, 2016年6月. 山上圭, 西條良仁, 楠瀬賢也, 山田博胤, 瀬野弘光, 原知也, 上野理絵, 門田宗之, 齋藤友子, 山﨑宙, 坂東左知子, 伊藤浩敬, 轟貴史, 松浦朋美, 伊勢孝之, 飛梅威, 山口浩司, 八木秀介, 添木武, 若槻哲三, 佐田政隆 :
生体腎移植後における腎静脈-外腸骨静脈間の血流動態変化が一因と考えられた深部静脈血栓症の一例,
第108回日本循環器学会中国・四国合同地方会, 2016年6月. 伊勢孝之, 八木秀介, 門田宗之, 瀬野弘光, 西條良仁, 上野理絵, 原知也, 齋藤友子, 山﨑宙, 坂東左知子, 伊藤浩敬, 轟貴史, 松浦朋美, 楠瀬賢也, 飛梅威, 山口浩司, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
循環器病棟入院患者における睡眠時無呼吸，夜間低酸素血症の合併 ∼連続パルスオキシメータを用いた解析∼,
第108回日本循環器学会中国・四国合同地方会, 2016年6月. 松浦朋美, 添木武, 飛梅威, 上野理絵, 坂東左知子, 山田博胤, 若槻哲三, 佐田政隆, 早渕康信, 小野朱美 :
心房中隔起源の持続性心房頻拍により頻脈誘発性心筋症をきたした小児の1例,
日本内科学会第114回四国地方会, 2016年5月. 伊藤浩敬, 若槻哲三, 山口浩司, 伊勢孝之, 上野理絵, 齋藤友子, 八木秀介, 山田博胤, 添木武, 佐田政隆 :
シロリムス溶出ステント留置7年後に初めて造影剤ステント周囲滲み出し像を認めその後も増大を呈した1例,
日本内科学会第114回四国地方会, 2016年5月. 西條良仁, 山田博胤, 楠瀬賢也, 瀬野弘光, 伊勢孝之, 八木秀介, 山口浩司, 添木武, 若槻哲三, 佐田政隆 :
ペースメーカー植込み術後に等容拡張期の異常な左室中部流入血流を認めた1例,
日本内科学会第114回四国地方会, 2016年5月. 西條良仁, 山田博胤, 楠瀬賢也, 瀬野弘光, 伊勢孝之, 八木秀介, 山口浩司, 添木武, 若槻哲三, 佐田政隆 :
ハンドグリップ負荷心エコー検査が心房細動合併心不全の治療評価に有用であった1例,
日本内科学会第114回四国地方会, 2016年5月. 山崎宙, 西條良仁, 伊勢孝之, 楠瀬賢也, 山口浩司, 若槻哲三, 佐田政隆, 木下肇, 黒部裕嗣, 北川哲也 :
左冠動脈入口部の高度狭窄により狭心症症状を繰り返した1例,
日本内科学会第114回四国地方会, 2016年5月. 村上貴寛, 八木秀介, 齋藤友子, 山口浩司, 伊勢孝之, 楠瀬賢也, 若槻哲三, 佐田政隆, 高島啓, 倉橋清衛 :
Kallmann症候群を合併した若年重症虚血性心疾患の1例,
日本内科学会第114回四国地方会, 2016年5月. Shusuke Yagi, Ken-ichi Aihara, Daiju Fukuda, A Takashima, Mika Bando, T Hara, Takayuki Ise, Kenya Kusunose, Koji Yamaguchi, Takeshi Tobiume, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Michio Shimabukuro, Masashi Akaike and Masataka Sata :
Reduced Ratio of Eicosapentaenoic Acid and Docosahexaenoic Acid to Arachidonic Acid is Associated with Early Onset of Acute Coronary Syndrome.,
第80回日本循環器学会学術集会, Mar. 2016. Koji Yamaguchi, Tetsuzo Wakatsuki, T Hara, M Kadota, R Ueno, Mika Bando, H Yamazaki, Y Saito, S Bando, Tomomi Matsuura, Kenya Kusunose, Takayuki Ise, Takeshi Tobiume, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Local Vascular Response after Paclitaxel Eluting Balloon Angioplasty Compared to Drug Eluting Stent Implantation in Stable Angina Patients.,
第80回日本循環器学会学術集会, Mar. 2016. S Bando, Takeshi Soeki, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Takeshi Tobiume, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Plasma Myeloperoxidase Activity is Associated with Atrial Substrate Remodeling in Patients with Atrial Fibrillation.,
第80回日本循環器学会学術集会, Mar. 2016. Tomomi Matsuura, Takeshi Soeki, Y Morimoto, S Bando, Takayuki Ise, Kenya Kusunose, Takeshi Tobiume, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Epicardial Adipose Tissue Produce Proinflammatory Cytokines and Influence the Pathogenesis of Atrial Fibrillation.,
第80回日本循環器学会学術集会, Mar. 2016. Y Hirata, Kenya Kusunose, Hirotsugu Yamada, Y Torii, S Nishio, Mika Bando, S Hayashi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Structural Remodeling of Left Atrial Appendage in Patients with Atrial Fibrillation.,
第80回日本循環器学会学術集会, Mar. 2016. Kenya Kusunose, Hirotsugu Yamada, S Nishio, Y Hirata, H Seno, Y Saijo, Takayuki Ise, Takeshi Tobiume, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki, B Griffin and Masataka Sata :
Echocardiographic Characteristics of Right Ventricular Size and Function are Associated with Cardiac Events in Sleep Apnea Syndrome.,
第80回日本循環器学会学術集会, Mar. 2016. 近藤大祐, 八木秀介, 伊勢孝之, 山口浩司, 若槻哲三, 楠瀬賢也, 松浦朋美, 飛梅威, 山田博胤, 添木武, 福田大受, 赤池雅史, 島袋充生, 佐田政隆 :
急性冠症候群発症時のイコサペント酸とドコサヘキサエン酸の血中濃度低下は慢性期冠動脈ステント内再狭窄の予測因子である,
第45回日本心脈管作動物質学会, 2016年2月. 高島啓, 福田大受, 田中君枝, 東邦康智, 平田陽一郎, 山田博胤, 添木武, 若槻哲三, 島袋充生, 佐田政隆 :
ω3系不飽和脂肪酸の脂質ラフト構造変化を介した抗動脈硬化作用の解明,
第45回日本心脈管作動物質学会, 2016年2月. 上田雄大, 島袋充生, Maimaituxun Gulinu, Salim Masdan Hotimah, 坂東左知子, 松浦朋美, 伊勢孝之, 楠瀬賢也, 飛梅威, 山口浩司, 岩瀬俊, 八木秀介, 福田大受, 山田博胤, 添木武, 若槻哲三, 原田雅史, 佐田政隆 :
冠症候群発症例における心臓周囲脂肪および腹部脂肪分布の検討,
第45回日本心脈管作動物質学会, 2016年2月. 上野理絵, 飛梅威, 山口浩司, 八木秀介, 山田博胤, 添木武, 若槻哲三, 島袋充生, 佐田政隆 :
当院で出産まで管理しえた心室頻拍合併妊娠の2症例,
日本内科学会第113回四国地方会, 2015年12月. 伊勢孝之, 西條良仁, 三木浩和, 賀川久美子, 瀬野弘光, 上野理絵, 原知也, 齋藤友子, 坂東美佳, 坂東左知子, 伊藤浩敬, 松浦朋美, 山口浩司, 飛梅威, 八木秀介, 山田博胤, 添木武, 若槻哲三, 安倍正博, 佐田政隆 :
auto-PBSCT とBortezomibの併用が著効した高度心機能障害を伴う原発性心アミロイドーシスの1例,
第107回日本循環器学会四国地方会, 2015年11月. 門田宗之, 伊勢孝之, 楠瀬賢也, 瀬野弘光, 上野理絵, 原知也, 齋藤友子, 高島啓, 坂東美佳, 山﨑宙, 坂東左知子, 伊藤浩敬, 飛梅威, 山口浩司, 八木秀介, 山田博胤, 添木武, 若槻哲三, 黒部裕嗣, 北川哲也, 佐田政隆 :
静脈洞型心房中隔欠損を合併した高齢難治性心不全に対し修復術が奏功した一例,
第107回日本循環器学会四国地方会, 2015年11月. 坂東左知子, 添木武, 松浦朋美, 飛梅威, 瀬野弘光, 西條良仁, 門田宗之, 原知也, 上野理絵, 齋藤友子, 坂東美佳, 山﨑宙, 伊藤浩敬, 伊勢孝之, 楠瀬賢也, 山口浩司, 八木秀介, 山田博胤, 若槻哲三, 佐田政隆 :
心室瘤を形成した心サルコイドーシス患者の薬剤抵抗性VT storm に対しアブレーションを行った一例,
第107回日本循環器学会四国地方会, 2015年11月. 西條良仁, 坂東美佳, 楠瀬賢也, 門田宗之, 伊勢孝之, 山田博胤, 西尾進, 山口浩司, 八木秀介, 添木武, 若槻哲三, 佐田政隆 :
ハンドグリップ負荷による心臓カテーテル検査および心エコー検査が治療評価に有用であった2例,
第107回日本循環器学会四国地方会, 2015年11月. 伊藤浩敬, 高島啓, 八木秀介, 瀬野弘光, 門田宗之, 原知也, 上野理絵, 齋藤友子, 山﨑宙, 坂東美佳, 坂東左知子, 松浦朋美, 楠瀬賢也, 伊勢孝之, 山口浩司, 飛梅威, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
重症筋無力症に対する免疫抑制療法中に生じた化膿性心膜炎の一例,
第107回日本循環器学会四国地方会, 2015年11月. 西條良仁, 齋藤友子, 山田博胤, 楠瀬賢也, 坂東美佳, 瀬野弘光, 門田宗之, 原知也, 上野理絵, 山﨑宙, 坂東左知子, 伊藤浩敬, 伊勢孝之, 山口浩司, 八木秀介, 岩瀬俊, 添木武, 若槻哲三, 佐田政隆 :
遅延造影MRI検査が診断の契機となった心アミロイドーシスの1例,
第107回日本循環器学会四国地方会, 2015年11月. 山下雄也, 伊勢孝之, 坂東美佳, 原知也, 高島啓, 山﨑宙, 齋藤友子, 坂東左知子, 楠瀬賢也, 飛梅威, 山口浩司, 八木秀介, 山田博胤, 添木武, 若槻哲三, 木下肇, 藤本鋭貴, 北川哲也, 佐田政隆 :
60歳代で発見され外科治療が奏功した大動脈縮窄症の1例,
第107回日本循環器学会四国地方会, 2015年11月. 近藤大祐, 八木秀介, 伊勢孝之, 山口浩司, 若槻哲三, 楠瀬賢也, 松浦朋美, 飛梅威, 山田博胤, 添木武, 福田大受, 赤池雅史, 島袋充生, 佐田政隆 :
急性冠症候群患者におけるスタチンのω3不飽和脂肪酸濃度へ影響,
第107回日本循環器学会四国地方会, 2015年11月. 加藤悠人, 飛梅威, 坂東左知子, 松浦朋美, 添木武, 瀬野弘光, 上野理絵, 門田宗之, 原知也, 齋藤友子, 高島啓, 山﨑宙, 坂東美佳, 伊藤浩敬, 伊勢孝之, 楠瀬賢也, 山口浩司, 八木秀介, 山田博胤, 若槻哲三, 佐田政隆 :
His束近傍に起源を認めるATP感受性心房頻拍7例に関する検討,
第107回日本循環器学会四国地方会, 2015年11月. M Kadota, Takayuki Ise, Shusuke Yagi, Kenya Kusunose, Hajime Kinoshita, Hirotsugu Kurobe, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Successful Surgical Repair of Aged Sinus Venous Connection : A Case Report,
第19回日本心不全学会学術集会, Oct. 2015. 伊勢孝之, 若槻哲三, 山口浩司, 坂東美佳, 門田宗之, 八木秀介, 山田博胤, 添木武, 佐田政隆 :
PTSMA術後に左室流出路狭窄の急性増悪を認めたHOCMの1例,
ストラクチャークラブ・ジャパンライブデモンストレーション2015, 2015年9月. 長野広実, 添木武, 坂東左知子, 松浦朋美, 飛梅威, 楠瀬賢也, 伊勢孝之, 山口浩司, 八木秀介, 福田大受, 山田博胤, 若槻哲三, 島袋充生, 佐田政隆 :
心房細動発症の予測因子-心電学的側面と心エコー学的側面からの検討-,
第63回日本心臓病学会学術集会, 2015年9月. 坂東左知子, 添木武, 飛梅威, 松浦朋美, 伊勢孝之, 楠瀬賢也, 山口浩司, 八木秀介, 山田博胤, 若槻哲三, 佐田政隆 :
薬剤抵抗性のPurkinje起源心室頻拍に対し，人工呼吸管理・PCPS装着下にカテーテルアブレーション治療を施行し，社会復帰に成功した若年例の一例,
第63回日本心臓病学会学術集会, 2015年9月. 瀬野弘光, 山田博胤, 楠瀬賢也, 坂東美佳, 西條良仁, 西尾進, 山尾雅美, 鳥居裕太, 平田有紀奈, 伊勢孝之, 八木秀介, 添木武, 若槻哲三, 佐田政隆 :
6分間歩行負荷心エコー検査を用いた運動負荷誘発性肺高血圧症例の検出とその特徴,
第63回日本心臓病学会学術集会, 2015年9月. 平田有紀奈, 山田博胤, 西尾進, 鳥居裕太, 天野里江, 山尾雅美, 坂東美佳, 林修司, 楠瀬賢也, 山口浩司, 添木武, 若槻哲三, 島袋充生, 佐田政隆 :
冠動脈疾患の非侵襲的診断における心臓周囲脂肪厚の付加的価値,
第63回日本心臓病学会学術集会, 2015年9月. 伊勢孝之, 楠瀬賢也, 松浦朋美, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
急性心筋梗塞後にBeckerⅠ型とⅢ型の心破裂をきたし，救命しえた一例,
第63回日本心臓病学会学術集会, 2015年9月. 西尾進, 山田博胤, 平田有紀奈, 西條良仁, 高川由利子, 坂東美佳, 林修司, 楠瀬賢也, 伊勢孝之, 山口浩司, 若槻哲三, 佐田政隆 :
冠攣縮性狭心症における心臓周囲脂肪厚の検討,
第63回日本心臓病学会学術集会, 2015年9月. 坂東美佳, 伊勢孝之, 山田博胤, 楠瀬賢也, 西尾進, 山口浩司, 八木秀介, 添木武, 若槻哲三, 佐田政隆 :
収縮期雑音を契機に発見された成人単純型大動脈縮窄症の1例,
第63回日本心臓病学会学術集会, 2015年9月. 齋藤友子, 若槻哲三, 山口浩司, 上野理絵, 山﨑宙, 伊勢孝之, 飛梅威, 佐田政隆 :
心臓カテーテル検査後に生じた橈骨仮性動脈瘤2例の検討,
第22回日本心血管インターベンション治療学会中国・四国地方会, 2015年9月. 山口浩司, 若槻哲三, 上野理絵, 齋藤友子, 山﨑宙, 伊勢孝之, 飛梅威, 佐田政隆 :
総腸骨動脈閉塞病変に対して留置したstentが大動脈中枢側へ伸展した1例,
第22回日本心血管インターベンション治療学会中国・四国地方会, 2015年9月. 伊勢孝之, 若槻哲三, 山口浩司, 上野理絵, 斎藤友子, 髙島啓, 山崎宙, 飛梅威, 佐田政隆 :
PTSMA後に左室流出路狭窄の一過性急性増悪を認めた閉塞性肥大型心筋症の1例,
第22回日本心血管インターベンション治療学会中国・四国地方会, 2015年9月. 山﨑宙, 若槻哲三, 山口浩司, 上野理絵, 齋藤友子, 伊勢孝之, 飛梅威, 佐田政隆 :
広範前壁心筋梗塞発症早期に左室内血栓を生じた2例の検討,
第22回日本心血管インターベンション治療学会中国・四国地方会, 2015年9月. 山田亮, 原知也, 八木秀介, 東島潤, 山田博胤, 添木武, 若槻哲三, 島田光生, 佐田政隆 :
下肢静脈血栓症を伴わない下大静脈限局型血栓症の1例,
第251回徳島医学会学術集会(平成27年度夏期), 2015年8月. H Yamazaki, Tetsuzo Wakatsuki, K Yamaguchi, Y Saito, A Takashima, Takayuki Ise, Takeshi Tobiume and Masataka Sata :
A Case of Preoperative VLST due to Multiple Inter-strut Hollow despite Heparin Replacement therapy, and OCT-guided PCI,
第24回日本心血管インターベンション治療学会, Jul. 2015. Koji Yamaguchi, Tetsuzo Wakatsuki, A Takashima, H Yamazaki, Y Saito, Takayuki Ise, Takeshi Tobiume and Masataka Sata :
Suppressive Local Coagulative and Inflammatory Response after Implantation of Biolimus-Eluting Stents,
第24回日本心血管インターベンション治療学会, Jul. 2015. 高島啓, 門田宗之, 山口浩司, 原知也, 齋藤友子, 坂東美佳, 坂東左知子, 松浦朋美, 伊勢孝之, 楠瀬賢也, 飛梅威, 八木秀介, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
IgA腎症の加療中に若年で発症した急性冠症候群の一例,
第106回日本循環器学会中国・四国合同地方会, 2015年6月. 山﨑宙, 山口浩司, 原知也, 高島啓, 坂東美佳, 齋藤友子, 坂東左知子, 松浦朋美, 楠瀬賢也, 伊勢孝之, 飛梅威, 八木秀介, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
右心不全を来した収縮性心膜炎合併心膜嚢胞の一例,
第106回日本循環器学会中国・四国合同地方会, 2015年6月. 山﨑宙, 八木秀介, 鳥居裕太, 天野里江, 西尾進, 原知也, 齋藤友子, 高島啓, 坂東美佳, 坂東左知子, 松浦朋美, 伊勢孝之, 楠瀬賢也, 飛梅威, 山口浩司, 山田博胤, 添木武, 若槻哲三, 島袋充生, 赤池雅史, 佐田政隆 :
深部静脈血栓症に対するエドキサバンの凝固因子に与える影響,
第106回日本循環器学会中国・四国合同地方会, 2015年6月. 山﨑宙, 八木秀介, 原知也, 高島啓, 坂東美佳, 齋藤友子, 坂東左知子, 松浦朋美, 伊勢孝之, 楠瀬賢也, 飛梅威, 山口浩司, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
家族性アミロイドポリニューロパチーを合併した心肥大の一例,
第106回日本循環器学会中国・四国合同地方会, 2015年6月. 坂東左知子, 添木武, 原知也, 齋藤友子, 坂東美佳, 山﨑宙, 高島啓, 松浦朋美, 伊勢孝之, 楠瀬賢也, 山口浩司, 飛梅威, 八木秀介, 山田博胤, 若槻哲三, 坂東正章, 佐田政隆 :
Brugada症候群に閉塞性肥大型心筋症を併発した一例,
第106回日本循環器学会中国・四国合同地方会, 2015年6月. 八木秀介, 山﨑宙, 楠瀬賢也, 伊勢孝之, 飛梅威, 山口浩司, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
肺アスペルギルス症に合併した肺動静脈血栓症の1例,
第106回日本循環器学会中国・四国合同地方会, 2015年6月. 瀬野弘光, 坂東美佳, 楠瀬賢也, 山田博胤, 高川由利子, 林修司, 齋藤友子, 山﨑宙, 高島啓, 坂東左知子, 松浦朋美, 伊勢孝之, 飛梅威, 山口浩司, 八木秀介, 添木武, 若槻哲三, 平田有紀奈, 西尾進, 島袋充生, 佐田政隆 :
CHADS2スコア低値例における左心耳機能の検討,
第106回日本循環器学会中国・四国合同地方会, 2015年6月. 飛梅威, 坂東左知子, 松浦朋美, 添木武, 今田久美子, 松本和久, 齋藤友子, 原知也, 高島啓, 山﨑宙, 坂東美佳, 伊勢孝之, 楠瀬賢也, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 若槻哲三, 赤池雅史, 佐田政隆 :
心房細動カテーテルアブレーションにおける放射線防護キャビンの放射線被爆低減効果について,
第106回日本循環器学会中国・四国合同地方会, 2015年6月. 楠瀬賢也, 山田博胤, ブライアングリフィン, 坂東美佳, 西條良仁, 西尾進, 伊勢孝之, 山口浩司, 八木秀介, 添木武, 若槻哲三, 佐田政隆 :
睡眠時呼吸障害患者の右室機能評価は予後予測において有用である,
第106回日本循環器学会中国・四国合同地方会, 2015年6月. 上野理絵, 坂東美佳, 山田博胤, 楠瀬賢也, 高川由利子, 瀬野弘光, 門田宗之, 原知也, 齋藤友子, 山﨑宙, 高島啓, 坂東左知子, 松浦朋美, 伊勢孝之, 飛梅威, 山口浩司, 八木秀介, 添木武, 若槻哲三, 島袋充生, 佐田政隆 :
間質性肺炎合併膠原病性肺高血圧症にボセンタンが奏功した1例,
第106回日本循環器学会中国・四国合同地方会, 2015年6月. 鈴木智子, 楠瀬賢也, 山田博胤, 坂東美佳, 西條良仁, 西尾進, 伊勢孝之, 山口浩司, 八木秀介, 添木武, 若槻哲三, 佐田政隆 :
IGg4関連疾患に伴う巨大冠動脈瘤および冠動脈周囲偽腫瘍を認めた1例,
第106回日本循環器学会中国・四国合同地方会, 2015年6月. 楠瀬賢也, 山田博胤, 坂東美佳, 西條良仁, 西尾進, 伊勢孝之, 山口浩司, 八木秀介, 岩瀬俊, 添木武, 若槻哲三, 佐田政隆 :
膠原病に伴う肺高血圧症の悪化予測:6分間歩行負荷心エコー図検査を用いた検討,
第106回日本循環器学会中国・四国合同地方会, 2015年6月. 原知也, 福田大受, 田中君枝, 東邦康智, 平田陽一郎, 八木秀介, 山田博胤, 添木武, 若槻哲三, 島袋充生, 佐田政隆 :
活性型第X凝固因子によるマクロファージ活性化を介した新しい動脈硬化進展機序の検討,
第2回日本心血管脳卒中学会学術集会, 2015年6月. 山﨑宙, 若槻哲三, 山口浩司, 八木秀介, 山田博胤, 添木武, 佐田政隆, 鹿草宏, 里見淳一郎, 永廣信治 :
広範前壁心筋梗塞発症早期に左心室内血栓を生じた2例,
第2回日本心血管脳卒中学会学術集, 2015年6月. 坂東左知子, 松浦朋美, 添木武, 飛梅威, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 若槻哲三, 佐田政隆 :
感染性心内膜炎から多発性脳塞栓発症により死亡に至った一例,
第2回日本心血管脳卒中学会学術集会, 2015年6月. 飛梅威, 坂東左知子, 松浦朋美, 添木武, 今田久美子, 松本和久, 原知也, 齋藤友子, 高島啓, 山﨑宙, 坂東美佳, 伊勢孝之, 楠瀬賢也, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 若槻哲三, 赤池雅史, 佐田政隆 :
心房細動カテーテルアブレーションにおける放射線防護キャビンの放射線被爆低減効果に関する検討,
第2回日本心血管脳卒中学会学術集会, 2015年6月. 山下雄也, 坂東美佳, 楠瀬賢也, 宮本亮介, 伊勢孝之, 山口浩司, 八木秀介, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
片麻痺および間代性痙攣でStroke Care Unit入室後に高度心機能低下をきたした1例,
第2回日本心血管脳卒中学会学術集会, 2015年6月. 曽我部周, 多田恵曜, 里見淳一郎, 桑山一行, 吉岡正太郎, 山口泉, 永廣信治, 山本伸昭, 山田博胤, 若槻哲三, 佐田政隆 :
当院における院内発症脳卒中症例の検討,
第2回日本心血管脳卒中学会学術集会, 2015年6月. 原知也, 八木秀介, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
アトピー性皮膚炎から感染性心内膜炎を来した1例,
日本内科学会第112回四国地方会, 2015年6月. Koji Yamaguchi, Tetsuzo Wakatsuki, T Hara, Y Takagawa, Mika Bando, A Takashima, H Yamazaki, S Bando, Tomomi Matsuura, Kenya Kusunose, Takayuki Ise, Takeshi Tobiume, Shusuke Yagi, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Differential Local Vascular Responses after Implantation of Biolimus-Eluting and Everolimus-Eluting Stents Compared with Sirolimus-Eluting and Bare Metal Stents.,
第79回日本循環器学会学術集会, Apr. 2015. T Hara, Daiju Fukuda, K Tanaka, Y Higashikuni, Y Hirata, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Inhibition of Activated Factor X Attenuates Neointima Formation after Wire-Mediated Vascular Injury.,
第79回日本循環器学会学術集会, Apr. 2015. T Hara, Daiju Fukuda, K Tanaka, Y Higashikuni, Y Hirata, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Inhibition of Activated Factor X Attenuates Vascular Inflammation and Atherosclerosis in ApoE-deficient Mice.,
第79回日本循環器学会学術集会, Apr. 2015. Takeshi Soeki, Tomomi Matsuura, S Bando, Takeshi Tobiume, T Hara, A Takashima, Mika Bando, H Yamazaki, Y Saito, Takayuki Ise, Kenya Kusunose, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Antiarrhythmic and Antiapoptotic Effects of C-type Natriuretic Peptide in Rats with Myocardial Ischemia/Reperfusion.,
第79回日本循環器学会学術集会, Apr. 2015. 西尾進, 山田博胤, 平田有紀奈, 鳥居裕太, 天野里江, 山尾雅美, 高川由利子, 坂東美佳, 林修司, 楠瀬賢也, 山口浩司, 若槻哲三, 佐田政隆 :
冠攣縮性狭心症における心臓周囲脂肪厚の意義∼超音波検査を用いた検討∼,
第26回日本心エコー図学会学術集会, 2015年3月. 原知也, 福田大受, 田中君江, 東邦康智, 平田陽一郎, 八木秀介, 山田博胤, 添木武, 若槻哲三, 島袋充生, 佐田政隆 :
活性型第X凝固因子によるマクロファージ活性化を介した新しい動脈硬化進展機序の検討,
第44回日本心脈管作動物質学会, 2015年2月. 松本康平, 楠瀬賢也, 松本和久, 高川由利子, 坂東美佳, 發知淳子, 松浦朋美, 伊勢孝之, 飛梅威, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
動脈周囲炎をきたしたIgG4関連疾患の1例,
第250回徳島医学会学術集会(平成26年度冬期), 2015年2月. 鈴木智子, 山崎宙, 近藤彰, 高川由利子, 坂東美佳, 發知淳子, 松浦朋美, 楠瀬賢也, 伊勢孝之, 飛梅威, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
活動性を評価するにあたりPET-CTが特に有効であった心サルコイドーシスの1例,
第250回徳島医学会学術集会(平成26年度冬期), 2015年2月. 武井美貴子, 飛梅威, 坂東左知子, 松浦朋美, 添木武, 今田久美子, 松本和久, 高川由利子, 原知也, 高島啓, 齋藤友子, 山崎宙, 坂東美佳, 伊勢孝之, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 若槻哲三, 佐田政隆 :
生理的ペーシングへのモード変更が心不全の改善に有効であった房室ブロックの1例,
第250回徳島医学会学術集会(平成26年度冬期), 2015年2月. 今田久美子, 伊勢孝之, 八木秀介, 高木恵理, 松本和久, 高川由利子, 原知也, 高島啓, 齋藤友子, 坂東美佳, 山﨑宙, 坂東左知子, 松浦朋美, 飛梅威, 山口浩司, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
慢性血栓塞栓性肺高血圧症にリオシグアトを使用した1症例,
第105回日本循環器学会四国地方会, 2014年12月. 伊勢孝之, 岩瀬俊, 高木恵理, 今田久美子, 松本和久, 高川由利子, 原知也, 齋藤友子, 高島啓, 山﨑宙, 坂東美佳, 坂東左知子, 松浦朋美, 飛梅威, 山口浩司, 八木秀介, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
心臓MRIガドリニウム遅延造影で検出できなかった心臓サルコイドーシス再燃の一例,
第105回日本循環器学会四国地方会, 2014年12月. 平田有紀奈, 山田博胤, 西尾進, 堀家由貴, 玉井佑里恵, 鳥居祐太, 天野里江, 山尾雅美, 高川由利子, 坂東美佳, 林修司, 楠瀬賢也, 伊勢孝之, 山口浩司, 八木秀介, 岩瀬俊, 添木武, 若槻哲三, 佐田政隆 :
頸動脈プラークスコア，心臓周囲脂肪厚と冠動脈硬化の関連:超音波検査を用いた検討,
第105回日本循環器学会四国地方会, 2014年12月. 高島啓, 若槻哲三, 山口浩司, 松本和久, 今田久美子, 高木恵理, 高川由利子, 原知也, 齋藤友子, 山﨑宙, 坂東美佳, 坂東左知子, 松浦朋美, 伊勢孝之, 飛梅威, 八木秀介, 岩瀬俊, 山田博胤, 添木武, 佐田政隆 :
冠動脈完全閉塞性病変の治療後慢性期に形成された二重血行路をOCTで観察し得た一例,
第105回日本循環器学会四国地方会, 2014年12月. 八木秀介, 鳥居祐太, 伊勢孝之, 山口浩司, 飛梅威, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 島袋充生, 赤池雅史, 佐田政隆 :
突然の片側性下肢腫脹を呈した変形性関節症の2例,
第105回日本循環器学会四国地方会, 2014年12月. 楠瀬賢也, 山田博胤, ポポヴィッチゾラン, 伊勢孝之, 山口浩司, 八木秀介, 岩瀬俊, 添木武, 若槻哲三, 佐田政隆 :
無症候性僧帽弁逆流症と大動脈弁逆流症の自然経過,
第105回日本循環器学会四国地方会, 2014年12月. 坂東左知子, 添木武, 今田久美子, 松本和久, 原知也, 高島啓, 山﨑宙, 坂東美佳, 齋藤友子, 松浦朋美, 伊勢孝之, 楠瀬賢也, 飛梅威, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 若槻哲三, 佐田政隆 :
右室流出路心外膜起源が疑われた突発性心室期外収縮の一例,
第105回日本循環器学会四国地方会, 2014年12月. 稲垣太造, 八木秀介, 伊勢孝之, 山口浩司, 飛梅威, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 島袋充生, 赤池雅史, 佐田政隆 :
治療抵抗性本態性高血圧に対する利尿剤の効果-インダパミドが効果的であった2例の検討-,
第105回日本循環器学会四国地方会, 2014年12月. 富永真由, 伊勢孝之, 坂東美佳, 今田久美子, 松本和久, 高川由利子, 原知也, 齋藤友子, 高島啓, 山﨑宙, 坂東左知子, 松浦朋美, 飛梅威, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 坂東正章, 佐田政隆 :
超選択的コントラストエコーを併用し経皮的中隔心筋焼灼術を有効に施行し得た閉塞性肥大型心筋症の1例,
第105回日本循環器学会四国地方会, 2014年12月. 伊勢孝之, 岩瀬俊, 高川由利子, 楠瀬賢也, 山口浩司, 八木秀介, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
心臓サルコイドーシス再燃に対してメトトレキサートの併用が有効であった1例,
第111回日本内科学会四国地方会, 2014年11月. 松浦朋美, 添木武, 西條良仁, 齋藤友子, 高島啓, 坂東美佳, 坂東左知子, 發知淳子, 伊勢孝之, 飛梅威, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 若槻哲三, 佐田政隆 :
筋強直性ジストロフィーに伴い二次性心筋症と心房頻拍を呈し，カテーテルアブレーションを施行した一例,
第62回日本心臓病学会学術集会, 2014年9月. 平田有紀奈, 山田博胤, 西尾進, 楠瀬賢也, 澤田直子, 高川由利子, 西條良仁, 坂東美佳, 發知淳子, 林修司, 添木武, 若槻哲三, 佐田政隆 :
心エコー法で計測する前室間溝心外膜脂肪厚はCTで計測した心外膜脂肪容積を反映する,
第62回日本心臓病学会学術集会, 2014年9月. 發知淳子, 山田博胤, 西條良仁, 坂東美佳, 高島啓, 伊勢孝之, 山口浩司, 八木秀介, 岩瀬俊, 添木武, 若槻哲三, 佐田政隆 :
薬剤抵抗性起立性調節障害に対する携帯型下肢陽圧装置の効果,
第62回日本心臓病学会学術集会, 2014年9月. 西尾進, 山田博胤, 楠瀬賢也, 平田有紀奈, 西條良仁, 坂東美佳, 發知淳子, 林修司, 添木武, 若槻哲三, 佐田政隆 :
S字状中隔と各種血管検査指標との関連,
第62回日本心臓病学会学術集会, 2014年9月. 坂東左知子, 添木武, 飛梅威, 松浦朋美, 伊勢孝之, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 若槻哲三, 佐田政隆 :
ATP 感受性リエントリー性心房頻拍の2症例,
第62回日本心臓病学会学術集会, 2014年9月. 原知也, 若槻哲三, 山口浩司, 伊勢孝之, 飛梅威, 八木秀介, 岩瀬俊, 山田博胤, 添木武, 佐田政隆 :
十分な術前ヘパリン置換にもかかわらず超遅発性ステント血栓症を発症した症例の検討-OCT による観察から-,
第62回日本心臓病学会学術集会, 2014年9月. 坂東美佳, 山田博胤, 西尾進, 林修司, 發知淳子, 西條良仁, 楠瀬賢也, 伊勢孝之, 山口浩司, 八木秀介, 岩瀬俊, 添木武, 若槻哲三, 佐田政隆 :
心房細動症例におけるCHADS2 およびCHA2DS2-VASc スコアと左心耳血流速度の関連,
第62回日本心臓病学会学術集会, 2014年9月. 添木武, 坂東左知子, 松浦朋美, 飛梅威, 高島啓, 坂東美佳, 發知淳子, 伊勢孝之, 山口浩司, 八木秀介, 福田大受, 岩瀬俊, 山田博胤, 若槻哲三, 島袋充生, 佐田政隆 :
心房細動におけるmicroRNAと心房リモデリングおよび予後との関係,
第62回日本心臓病学会学術集会, 2014年9月. 西條良仁, 山田博胤, 西尾進, 坂東美佳, 發知淳子, 林修司, 澤田直子, 高川由利子, 平田有紀奈, 山口浩司, 岩瀬俊, 添木武, 若槻哲三, 佐田政隆 :
僧帽弁血流速波形の前負荷増大に対する反応性には左房機能が関与する,
第62回日本心臓病学会学術集会, 2014年9月. 山口浩司, 若槻哲三, 伊勢孝之, 高島啓, 齋藤友子, 飛梅威, 岩瀬俊, 佐田政隆 :
第一世代薬剤溶出性ステントの超遅発性血栓症の2例-病歴・病変観察の観点から-,
第21回日本心血管インターベンション治療学会中国・四国地方会, 2014年9月. 高島啓, 若槻哲三, 山口浩司, 齋藤友子, 山﨑宙, 伊勢孝之, 飛梅威, 岩瀬俊, 佐田政隆 :
CTO治療後慢性期に形成された二重血行路をOCTで観察した一例,
第21回日本心血管インターベンション治療学会中国・四国地方会, 2014年9月. A Takashima, Daiju Fukuda, K Tanaka, Y Higashikuni, Y Hirata, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Combined administration of eicosapentaenoic acid and docosahexaenoic acid reduces atherosclerotic lesion in apolipoprotein E-deficient mice.,
ESC 2014, Aug. 2014. 富永真由, 伊勢孝之, 坂東美佳, 今田久美子, 松本和久, 高川由利子, 高木恵理, 西條良仁, 原知也, 齋藤友子, 高島啓, 山﨑宙, 坂東左知子, 松浦朋美, 發知淳子, 飛梅威, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 坂東正章, 佐田政隆 :
超選択的コントラストエコーを併用し経皮的中隔心筋焼灼術を有効に施行し得た閉塞性肥大型心筋症の一例,
第249回徳島医学会学術集会(平成26年度夏期), 2014年7月. 亀田香奈子, 伊勢孝之, 西條良仁, 今田久美子, 松本和久, 高川由利子, 高木恵理, 原知也, 齋藤友子, 高島啓, 山﨑宙, 坂東美佳, 坂東左知子, 松浦朋美, 發知淳子, 飛梅威, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 近藤剛, 佐田政隆 :
原発性アルドステロン症患者に高度冠攣縮を合併し心筋梗塞を発症した1症例,
第249回徳島医学会学術集会(平成26年度夏期), 2014年7月. A Takashima, Tetsuzo Wakatsuki, Koji Yamaguchi, K Ogasawara, Takeshi Tobiume, Takashi Iwase and Masataka Sata :
Local coagulation response and angiographic peri-stent contrast staining up to five years after sirolimus-eluting stent implantation.,
第23回日本心血管インターベンション治療学会, Jul. 2014. Koji Yamaguchi, Tetsuzo Wakatsuki, A Takashima, K Ogasawara, Takeshi Tobiume, Takashi Iwase and Masataka Sata :
Differential Responses of Local Coagulation after Implantation of Second-Generation Drug-Eluting Stent Compared with First-Generation Drug-Eluting Stents.,
第23回日本心血管インターベンション治療学会, Jul. 2014. 西條良仁, 伊勢孝之, 三木浩和, 賀川久美子, 原知也, 齋藤友子, 高島啓, 坂東美佳, 坂東左知子, 松浦朋美, 發知淳子, 山口浩司, 飛梅威, 八木秀介, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 奥村宇信, 藤永裕之, 佐田政隆 :
高度心機能障害を伴う原発性心アミロイドーシスに対しauto-PBSCTを施行し得た一例,
第104回日本循環器学会中国・四国合同地方会, 2014年7月. 澤田直子, 高川由利子, 發知淳子, 西條良仁, 高島啓, 坂東美佳, 山崎宙, 坂東左知子, 松浦朋美, 伊勢孝之, 飛梅威, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
心エコー検査による大動脈弁逆流の重症度判定が困難であった大動脈弁位生体弁機能不全の一例,
第104回日本循環器学会中国・四国合同地方会, 2014年7月. 原知也, 八木秀介, 伊勢孝之, 飛梅威, 山口浩司, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
大動脈解離の急性期降圧療法における経皮吸収型β1遮断薬の使用経験,
第104回日本循環器学会中国・四国合同地方会, 2014年7月. 鳥居裕太, 山田博胤, 西尾進, 平田有紀奈, 天野里江, 山尾雅美, 高川由利子, 西條良仁, 坂東美佳, 發知淳子, 林修司, 添木武, 若槻哲三, 佐田政隆 :
遺残坐骨動脈奇形に伴う浅大腿動脈閉塞の1例,
第104回日本循環器学会中国・四国合同地方会, 2014年7月. 坂東左知子, 添木武, 飛梅威, 松浦朋美, 今田久美子, 松本和久, 高木恵理, 西條良仁, 原知也, 齋藤友子, 高島啓, 坂東美佳, 山崎宙, 伊勢孝之, 發知淳子, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 若槻哲三, 佐田政隆 :
ATP感受性リエントリー性心房頻拍の一例,
第104回日本循環器学会中国・四国合同地方会, 2014年7月. 松浦朋美, 添木武, 松本和久, 今田久美子, 西條良仁, 高木恵理, 原知也, 齋藤友子, 高島啓, 坂東美佳, 山崎宙, 坂東左知子, 發知淳子, 伊勢孝之, 飛梅威, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 若槻哲三, 佐田政隆 :
心房頻拍と心不全を契機に発覚した筋強直性ジストロフィーの一例,
第104回日本循環器学会中国・四国合同地方会, 2014年7月. 坂東左知子, 添木武, 飛梅威, 松浦朋美, 齋藤友子, 高島啓, 坂東美佳, 山崎宙, 伊勢孝之, 發知淳子, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 若槻哲三, 阪田美穂, 早渕康信, 井上美紀, 森一博, 木下学, 佐田政隆 :
薬剤抵抗性特発性心室頻拍に対し，PCPS下にアブレーション治療を施行し，社会復帰に成功した若年例の一例,
第104回日本循環器学会中国・四国合同地方会, 2014年7月. 松本和久, 若槻哲三, 高島啓, 山口浩司, 西條良仁, 高木恵理, 原知也, 齋藤友子, 高川由利子, 山崎宙, 坂東美佳, 坂東左知子, 松浦朋美, 伊勢孝之, 發知淳子, 飛梅威, 八木秀介, 岩瀬俊, 山田博胤, 添木武, 佐田政隆 :
シロリムス溶出ステント留置7年後に初めて造影剤ステント周囲滲み出し像と局所凝固反応亢進を認めた一例,
第104回日本循環器学会中国・四国合同地方会, 2014年7月. 原知也, 若槻哲三, 山口浩司, 伊勢孝之, 飛梅威, 八木秀介, 岩瀬俊, 山田博胤, 添木武, 佐田政隆 :
十分な術前ヘパリン置換にもかかわらず超遅発性ステント血栓症を発症した症例-OCTによる観察からの検討-,
第104回日本循環器学会中国・四国合同地方会, 2014年7月. 今田久美子, 伊勢孝之, 原知也, 八木秀介, 岩瀬俊, 西條良仁, 小笠原梢, 高島啓, 坂東美佳, 坂東左知子, 松浦朋美, 發知淳子, 飛梅威, 山口浩司, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
心不全を合併した頻脈性心房細動にランジオロールを有効に使用することができた2症例,
第104回日本循環器学会中国・四国合同地方会, 2014年7月. 高川由利子, 八木秀介, 山田博胤, 林修司, 發知淳子, 坂東美佳, 山口浩司, 伊勢孝之, 飛梅威, 岩瀬俊, 添木武, 若槻哲三, 佐田政隆 :
母児ともに救命できた母児間輸血症候群と妊娠高血圧腎症に合併した急性心不全の一例,
第104回日本循環器学会中国・四国合同地方会, 2014年7月. 西尾進, 山田博胤, 真鍋泰毅, 佐藤光代, 平岡葉月, 河野裕美, 平田有紀奈, 天野里江, 西條良仁, 高川由利子, 坂東美佳, 發知淳子, 林修司, 添木武, 若槻哲三, 佐田政隆 :
血流量の増加は%FMDを増大させる,
第104回日本循環器学会中国・四国合同地方会, 2014年7月. 原知也, 伊勢孝之, 飛梅威, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
Vascular endothelial growth factor (VEGF)阻害薬の眼内投与中に急性冠症候群を発症した4症例の検討,
第104回日本循環器学会中国・四国合同地方会, 2014年7月. 齋藤友子, 伊勢孝之, 發知淳子, 山口浩司, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 後東久嗣, 佐田政隆 :
左室収縮不全と間質性肺炎に伴う肺高血圧症を合併した皮膚筋炎の1例,
第110回日本内科学会四国地方会, 2014年6月. 坂東左知子, 添木武, 飛梅威, 松浦朋美, 山口浩司, 山田博胤, 若槻哲三, 佐田政隆, 井野口卓, 折野俊介 :
左室前乳頭筋起源の特発性心室性不整脈の1例,
第110回日本内科学会四国地方会, 2014年6月. 齋藤友子, 伊勢孝之, 發知淳子, 山口浩司, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 佐田政隆, 後東久嗣 :
左室収縮不全と間質性肺炎に伴う肺高血圧症を合併した皮膚筋炎の1例,
第110回日本内科学会四国地方会, 2014年6月. 松浦朋美, 添木武, 山口浩司, 八木秀介, 福田大受, 岩瀬俊, 山田博胤, 若槻哲三, 島袋充生, 佐田政隆 :
心房高頻度刺激を行った糖尿病モデルラットにおける直接レニン阻害薬の内皮機能障害抑制効果,
第1回日本心血管脳卒中学会学術集会, 2014年6月. 平田有紀奈, 山田博胤, 西尾進, 山尾雅美, 鳥居裕太, 坂東美佳, 林修司, 發知淳子, 西條良仁, 添木武, 若槻哲三, 佐田政隆 :
頸動脈プラークスコアおよび心外膜脂肪厚により冠動脈狭窄が予測できるか?,
第25回日本心エコー図学会学術集会, 2014年4月. 平田有紀奈, Hirotsugu Yamada, 西尾進, 鳥居裕太, 山尾雅美, Mika Bando, 林修司, Junko Hotsuchi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
冠動脈硬化と関連するのはSubepicardial Fat か，Pericardil Fat か,
第78回日本循環器学会学術集会, Mar. 2014. S Bando, Takeshi Soeki, T Matsuura, Takeshi Tobiume, T Hara, A Takashima, Mika Bando, K Ogasawara, Y Saito, Junko Hotsuchi, E Kimura, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Takashi Iwase, Daiju Fukuda, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Atrial late potentials and atrial substrate remodeling in patients with atrial fibrillation.,
第78回日本循環器学会学術集会, Mar. 2014. S Bando, Takeshi Soeki, T Hara, A Takashima, Mika Bando, K Ogasawara, Y Saito, T Matsuura, Junko Hotsuchi, E Kimura, Takayuki Ise, Takeshi Tobiume, Koji Yamaguchi, Shusuke Yagi, Takashi Iwase, Daiju Fukuda, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro, Kenji Kangawa and Masataka Sata :
Ghrelin ameliorates the progression of experimental autoimmune myocarditis.,
第78回日本循環器学会学術集会, Mar. 2014. Koji Yamaguchi, Tetsuzo Wakatsuki, T Hara, K Ogasawara, Mika Bando, A Takashima, S Bando, T Matsuura, Takayuki Ise, Junko Hotsuchi, Takeshi Tobiume, Shusuke Yagi, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Differential responses of local coagulation after implantation of biolimus-eluting and everolimus-eluting stents compared with sirolimus-eluting and bare metal stents.,
第78回日本循環器学会学術集会, Mar. 2014. Mika Bando, Hirotsugu Yamada, S Nishio, Junko Hotsuchi, S Hayashi, E Kimura, Takayuki Ise, T Matsuura, Takeshi Tobiume, Koji Yamaguchi, Shusuke Yagi, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Parallel changes in sonographic characteristics of carotid and coronary plaques.,
第78回日本循環器学会学術集会, Mar. 2014. Takayuki Ise, Shusuke Yagi, Takashi Iwase, Masashi Akaike, A Takashima, Mika Bando, S Bando, T Matsuura, Junko Hotsuchi, Takeshi Tobiume, Koji Yamaguchi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Impact of cardiac rehabilitation on oxidized stress in patients with heart failure.,
第78回日本循環器学会学術集会, Mar. 2014. T Matsuura, Takeshi Soeki, R Ota, T Hara, Y Saito, K Ogasawara, A Takashima, Mika Bando, S Bando, Junko Hotsuchi, E Kimura, Takayuki Ise, Takeshi Tobiume, Koji Yamaguchi, Shusuke Yagi, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki and Masataka Sata :
Increased local production of c-type natriuretic peptide in patients with vasospastic angina.,
第78回日本循環器学会学術集会, Mar. 2014. Takeshi Soeki, S Bando, T Matsuura, Takeshi Tobiume, T Hara, R Ota, A Takashima, Mika Bando, K Ogasawara, Y Saito, Takayuki Ise, Junko Hotsuchi, E Kimura, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Relationship between local production of microRNA-328 and atrial substrate remodeling in atrial fibrillation.,
第78回日本循環器学会学術集会, Mar. 2014. 今田久美子, 八木秀介, 山口浩司, 若槻哲三, 伊勢孝之, 太田理絵, 門田宗之, 高島啓, 松浦朋美, 飛梅威, 岩瀬俊, 山田博胤, 添木武, 赤池雅史, 佐田政隆 :
心不全を合併した腎血管性高血圧に対する経皮的腎動脈形成術の有効性,
第248回徳島医学会学術集会, 2014年2月. 松本和久, 高島啓, 山口浩司, 若槻哲三, 西條良仁, 高木恵理, 原知也, 齋藤友子, 小笠原梢, 坂東美佳, 坂東左知子, 松浦朋美, 伊勢孝之, 發知淳子, 木村恵理子, 飛梅威, 八木秀介, 岩瀬俊, 山田博胤, 添木武, 佐田政隆 :
シロリムス溶出ステント留置7年後に初めて造影剤ステント周囲滲み出し像を認めた一例,
第248回徳島医学会学術集会, 2014年2月. 八木秀介, 粟飯原賢一, 赤池雅史, 松本幸子, 福田大受, 松浦朋美, 伊勢孝之, 山口浩司, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 島袋充生, 松本俊夫, 佐田政隆 :
DPP-4阻害薬の血糖降下作用に対する有効性予測因子,
第248回徳島医学会学術集会, 2014年2月. 坂東左知子, 添木武, 飛梅威, 松浦朋美, 西條良仁, 高木恵理, 原知也, 小笠原梢, 坂東美佳, 齋藤友子, 高島啓, 發知淳子, 木村恵理子, 伊勢孝之, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 若槻哲三, 坂東正章, 佐田政隆 :
Aorta-mitral continuityが起源の心房頻拍の一例,
第103回日本循環器学会四国地方会, 2013年12月. 發知淳子, 山田博胤, 原知也, 太田理絵, 高島啓, 坂東美佳, 小笠原梢, 坂東左知子, 松浦朋美, 伊勢孝之, 木村恵理子, 飛梅威, 山口浩司, 八木秀介, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
下肢陽圧負荷の効果があった薬剤抵抗性起立性低血圧の2症例,
第103回日本循環器学会四国地方会, 2013年12月. 高島啓, 八木秀介, 高木恵理, 木下肇, 神原保, 原知也, 太田理絵, 坂東美佳, 坂東左知子, 伊勢孝之, 松浦朋美, 發知淳子, 飛梅威, 山口浩司, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 木村建彦, 北川哲也, 佐田政隆 :
冠静脈洞に疣贅が認められた冠動静脈瘻を合併した感染性心内膜炎の一例,
第103回日本循環器学会四国地方会, 2013年12月. 生田奈央, 高島啓, 原知也, 伊勢孝之, 島袋充生, 西條良仁, 高木恵理, 太田理絵, 齋藤友子, 坂東美佳, 坂東左知子, 松浦朋美, 發知淳子, 飛梅威, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
心身症として見過ごされてきた体位性起立頻脈症候群を的確に診断・治療し得た1例,
第103回日本循環器学会四国地方会, 2013年12月. 西條良仁, 松浦朋美, 飛梅威, 添木武, 坂東左知子, 高木恵理, 太田理絵, 原知也, 小笠原梢, 齋藤友子, 高島啓, 坂東美佳, 發知淳子, 木村恵理子, 伊勢孝之, 八木秀介, 岩瀬俊, 山田博胤, 若槻哲三, 佐田政隆 :
上位共通路の存在が示唆され室房ブロックを伴っても持続する2種類の房室結節リエントリー性頻拍を認めた1例,
第103回日本循環器学会四国地方会, 2013年12月. 坂東左知子, 飛梅威, 添木武, 松浦朋美, 西條良仁, 高木恵理, 原知也, 小笠原梢, 坂東美佳, 齋藤友子, 高島啓, 發知淳子, 木村恵理子, 伊勢孝之, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 若槻哲三, 佐田政隆 :
AMI急性期のVT/VF stormに対しtriggered PVC ablation を施行した一例,
第103回日本循環器学会四国地方会, 2013年12月. 松浦朋美, 飛梅威, 添木武, 坂東左知子, 高木恵理, 西條良仁, 太田理絵, 原知也, 齋藤友子, 小笠原梢, 高島啓, 坂東美佳, 伊勢孝之, 發知淳子, 木村恵理子, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 若槻哲三, 佐田政隆 :
ペースメーカー植込みの是非に検討を要した洞心不全症候群の一例,
第103回日本循環器学会四国地方会, 2013年12月. 石井亜由美, 西川幸治, 伊勢孝之, 八木秀介, 岩瀬俊, 門田宗之, 西條良仁, 高島啓, 松浦朋美, 發知淳子, 飛梅威, 山口浩司, 山田博胤, 添木武, 若槻哲三, 中山泰介, 赤池雅史, 加藤真介, 北川哲也, 佐田政隆 :
人工呼吸管理中の心不全症例に心臓リハビリテーションが有効に施行しえた症例,
第103回日本循環器学会四国地方会, 2013年12月. 伊勢孝之, 八木秀介, 岩瀬俊, 西條良仁, 高木恵理, 太田理絵, 門田宗之, 原知也, 小笠原梢, 高島啓, 坂東美佳, 坂東左知子, 松浦朋美, 發知淳子, 飛梅威, 山口浩司, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
当院でのAdaptive-Servo Ventilationが有効であった拡張障害心不全の症例検討,
第103回日本循環器学会四国地方会, 2013年12月. 小笠原梢, 伊勢孝之, 山口浩司, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
Fallot四徴症に対する根治術施行30年後に左心不全を合併した1例,
第109回日本内科学会四国地方会, 2013年12月. 玉置俊輔, 原知也, 伊勢孝之, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
冠攣縮および器質的冠狭窄を合併したBuerger病の1例,
第109回日本内科学会四国地方会, 2013年12月. Takayuki Ise, Takashi Iwase, Hirotsugu Yamada, Shusuke Yagi, Takeshi Tobiume, Koji Yamaguchi, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Progression of a Case of Myocardial Damage Caused by Beckers Muscular Dystrophy.,
第17回日本心不全学会学術集会, Nov. 2013. 太田理絵, 今田久美子, 八木秀介, 坂東左知子, 松浦朋美, 伊勢孝之, 發知淳子, 上田由佳, 飛梅威, 山口浩司, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
冠灌流域に合致しない心電図誘導にJ波を認めた急性冠症候群の一例,
第61回日本心臓病学会学術集会, 2013年9月. 太田理絵, 今田久美子, 八木秀介, 坂東左知子, 松浦朋美, 伊勢孝之, 發知淳子, 上田由佳, 飛梅威, 山口浩司, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
経皮的腎動脈形成術により難治性心不全が改善した両側腎動脈狭窄症の1例,
第61回日本心臓病学会学術集会, 2013年9月. 門田宗之, 伊勢孝之, 八木秀介, 岩瀬俊, 赤池雅史, 原知也, 太田理絵, 坂東美佳, 高島啓, 坂東左知子, 松浦朋美, 山口浩司, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
慢性心不全患者に対するトルバプタン投与における薬物血中濃度と利尿効果の検討,
第61回日本心臓病学会学術集会, 2013年9月. 伊勢孝之, 岩瀬俊, 赤池雅史, 西尾進, 山口浩司, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
Intramural Hematoma症例のUlcer Like Projection形成と拡大における穿通枝の重要性,
第61回日本心臓病学会学術集会, 2013年9月. 伊勢孝之, 岩瀬俊, 山田博胤, 坂東美佳, 西尾進, 山口浩司, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
Becker型筋ジストロフィーによる心筋障害の経過を観察し得た1例,
第61回日本心臓病学会学術集会, 2013年9月. 岩瀬俊, 髙尾正一郎, 太田理絵, 山口浩司, 赤池雅史, 伊勢孝之, 山田博胤, 添木武, 若槻哲三, 原田雅史, 佐田政隆 :
3ステラ非造影心臓MRI検査が左室内壁在血栓の検出ならびに治療方針決定に有用であった無症候性心筋虚血の1例,
第61回日本心臓病学会学術集会, 2013年9月. 岩瀬俊, 髙尾正一郎, 赤池雅史, 伊勢孝之, 八木秀介, 山口浩司, 山田博胤, 添木武, 若槻哲三, 西岡安彦, 原田雅史, 佐田政隆 :
左室収縮不全を伴う心サルコイドーシスと他の心疾患鑑別におけるガドリニウム遅延造影定量評価の有用性,
第61回日本心臓病学会学術集会, 2013年9月. 平田有紀奈, 山田博胤, 西尾進, 真鍋泰毅, 友藤達陽, 天野里江, 鳥居裕太, 山尾雅美, 坂東美佳, 林修司, 伊勢孝之, 山口浩司, 岩瀬俊, 添木武, 若槻哲三, 佐田政隆 :
冠動脈硬化症と各種脂肪厚との関連∼超音波検査を用いた検討∼,
第61回日本心臓病学会学術集会, 2013年9月. 山口浩司, 若槻哲三, 坂東美佳, 高島啓, 伊勢孝之, 岩瀬俊, 山田博胤, 添木武, 佐田政隆 :
Everolimus-eluting stent留置後における局所凝固反応とステント長の関連性,
第61回日本心臓病学会学術集会, 2013年9月. 安岡紗哉香, 山田博胤, 坂東美佳, 林修司, 西尾進, 天野里江, 平田有紀奈, 横倉航一, 伊勢孝之, 山口浩司, 岩瀬俊, 添木武, 若槻哲三, 佐田政隆 :
たこつぼ型心筋症の予後と回復過程に関する検討,
第61回日本心臓病学会学術集会, 2013年9月. 林修司, 山田博胤, 西尾進, 坂東美佳, 平田有紀奈, 伊勢孝之, 山口浩司, 岩瀬俊, 添木武, 若槻哲三, 佐田政隆 :
冠動脈疾患におけるAugmentation indexの臨床的有用性についての検討,
第61回日本心臓病学会学術集会, 2013年9月. 若槻哲三, 山口浩司, 伊勢孝之, 八木秀介, 岩瀬俊, 山田博胤, 添木武, 佐田政隆 :
OCTにてmicrochannel構造を認める冠動脈プラークの局所炎症性の評価,
第61回日本心臓病学会学術集会, 2013年9月. 添木武, 坂東左知子, 松浦朋美, 高島啓, 坂東美佳, 發知淳子, 伊勢孝之, 飛梅威, 山口浩司, 八木秀介, 福田大受, 岩瀬俊, 山田博胤, 若槻哲三, 島袋充生, 佐田政隆 :
心房細動におけるPentraxin3と心房リモデリングおよび予後との関係,
第61回日本心臓病学会学術集会, 2013年9月. 坂東左知子, 添木武, 植松悦子, 松浦朋美, 伊勢孝之, 發知淳子, 飛梅威, 山口浩司, 八木秀介, 岩瀬俊, 福田大受, 山田博胤, 若槻哲三, 島袋充生, 寒川賢治, 佐田政隆 :
自己免疫性心筋炎に対するグレリンの効果,
第61回日本心臓病学会学術集会, 2013年9月. 西尾進, 山田博胤, 平田有紀奈, 鳥居裕太, 天野里江, 山尾雅美, 真鍋泰毅, 友藤達陽, 坂東美佳, 林修司, 伊勢孝之, 山口浩司, 岩瀬俊, 添木武, 若槻哲三, 佐田政隆 :
各種血管機能検査指標における性差の影響,
第61回日本心臓病学会学術集会, 2013年9月. 高島啓, 若槻哲三, 山口浩司, 植田初江, 田端実, 小笠原梢, 飛梅威, 岩瀬俊, 高梨秀一郎, 佐田政隆 :
各種冠動脈ステント再狭窄病変の病理学的所見の比較 -冠動脈バイパス術症例での検討-,
第20回日本心血管インターベンション治療学会中国・四国地方会, 2013年9月. 山口浩司, 若槻哲三, 高島啓, 小笠原梢, 飛梅威, 岩瀬俊, 佐田政隆 :
各種冠動脈ステント留置後の慢性期局所凝固反応の比較,
第20回日本心血管インターベンション治療学会中国・四国地方会, 2013年9月. 今田久美子, 太田理絵, 八木秀介, 山口浩司, 若槻哲三, 岩瀬俊, 西條良仁, 高木恵理, 門田宗之, 原知也, 齋藤友子, 高島啓, 坂東美佳, 坂東左知子, 松浦朋美, 伊勢孝之, 發知淳子, 飛梅威, 山田博胤, 添木武, 佐田政隆, 春藤譲冶 :
経皮的腎動脈形成術により難治性心不全が改善したCardiac disturbance syndromeの1例,
第247回徳島医学会学術集会, 2013年8月. 生田奈央, 高島啓, 原知也, 伊勢孝之, 西條良仁, 高木恵理, 門田宗之, 太田理絵, 齋藤友子, 坂東美佳, 坂東左知子, 松浦朋美, 發知淳子, 飛梅威, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 佐田政隆, 島袋充生, 福田大受, 友竹正人 :
心身症として見過ごされていた体位性起立頻脈症候群を的確に診断・治療し得た一例,
第247回徳島医学会学術集会, 2013年8月. 門田宗之, 伊勢孝之, 八木秀介, 岩瀬俊, 太田理絵, 原知也, 高島啓, 坂東美佳, 坂東左知子, 松浦朋美, 發知淳子, 飛梅威, 山口浩司, 山田博胤, 添木武, 若槻哲三, 佐田政隆, 赤池雅史 :
慢性心不全における新規利尿薬tolvaptanの効果予測因子,
第247回徳島医学会学術集会, 2013年8月. 石井亜由美, 西川幸治, 加藤真介, 伊勢孝之, 八木秀介, 岩瀬俊, 上田由佳, 門田宗之, 高島啓, 飛梅威, 山口浩司, 山田博胤, 添木武, 若槻哲三, 佐田政隆, 中川泰介, 北川哲也, 赤池雅史 :
人工呼吸管理中に心臓リハビリを有効に施行しえた開心術後の心不全症例,
第247回徳島医学会学術集会, 2013年8月. 西條良仁, 松浦朋美, 飛梅威, 添木武, 坂東左知子, 高木恵理, 太田理絵, 門田宗之, 原知也, 齋藤友子, 高島啓, 坂東美佳, 伊勢孝之, 發知淳子, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 若槻哲三, 佐田政隆, 三木延茂 :
室房ブロックを伴っても持続する2種類の房室結節リエントリー性頻拍を認め，上位共通路の存在が示唆された1例,
第247回徳島医学会学術集会, 2013年8月. 太田理絵, 八木秀介, 若槻哲三, 岩瀬俊, 西條良仁, 高木恵理, 門田宗之, 原知也, 齋藤友子, 高島啓, 坂東美佳, 坂東左知子, 松浦朋美, 伊勢孝之, 發知淳子, 飛梅威, 山口浩司, 山田博胤, 添木武, 佐田政隆, 今田久美子, 髙尾正一郎 :
急性期の心電図でJ波を認めた急性心筋梗塞の一例,
第247回徳島医学会学術集会, 2013年8月. Toshiyuki Niki, Tetsuzo Wakatsuki, Koji Yamaguchi, Yoshio Taketani, Takashi Iwase and Masataka Sata :
Effects of additional Eicosapentaenoic Acid on Inflammatory Cytokines and Coronary Plaque Component Assessed by Integrated Backscatter Intravascular Ultrasound.,
第22回日本心血管インターベンション治療学会学術集会, Jul. 2013. Koji Yamaguchi, Tetsuzo Wakatsuki, Toshiyuki Niki, Yoshio Taketani, Takashi Iwase and Masataka Sata :
Local Coagulation Response after Sirolimus-eluting, Zotarolimus-eluting, and Bare-metal Stents Implantation.,
第22回日本心血管インターベンション治療学会学術集会, Jul. 2013. 八木秀介, 發知淳子, 山田博胤, 岩瀬俊, 伊勢孝之, 山口浩司, 添木武, 若槻哲三, 佐田政隆, 近藤剛史 :
高血圧・糖尿病・脂質異常症・脳心血管障害を合併した原発性副甲状腺機能亢進症の1例,
日本内科学会第108回四国地方会, 2013年6月. 坂東左知子, 山口浩司, 添木武, 太田理絵, 松浦朋美, 岩瀬俊, 山田博胤, 若槻哲三, 佐田政隆, 四宮秀美 :
恒久ペースメーカ植込み後に発見された無症候性内頚静脈血栓の1例,
日本内科学会第108回四国地方会, 2013年6月. 太田理絵, 山口浩司, 發知淳子, 八木秀介, 岩瀬俊, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
41歳で初めて診断された肺動静脈瘻合併右肺動脈上行大動脈起始症の1例,
日本内科学会第108回四国地方会, 2013年6月. 平田有紀奈, 西尾進, 山田博胤, 發知淳子, 坂東美佳, 林修司, 冨田紀子, 伊勢孝之, 仁木敏之, 山口浩司, 八木秀介, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 佐田政隆 :
冠動脈狭窄と関連する脂肪組織はどれか?∼超音波検査を用いた検討∼,
第102回日本循環器学会中国・四国合同地方会, 2013年5月. 西尾進, 山田博胤, 發知淳子, 平田有紀奈, 坂東美佳, 林修司, 冨田紀子, 伊勢孝之, 仁木敏之, 山口浩司, 八木秀介, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 佐田政隆 :
高血圧患者の腎末梢血管抵抗に対するイルベサルタンの効果,
第102回日本循環器学会中国・四国合同地方会, 2013年5月. 原知也, 門田宗之, 川端豊, 太田理絵, 高島啓, 坂東美佳, 坂東左知子, 松浦朋美, 上田由佳, 冨田紀子, 伊勢孝之, 仁木敏之, 山口浩司, 八木秀介, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
スピロノラクトンを中心とした薬物療法で30年間経過を観察しえたが，病勢制御困難となり手術療法を要したアルドステロン産生腺腫の一例,
第102回日本循環器学会中国・四国合同地方会, 2013年5月. 太田理絵, 山口浩司, 門田宗之, 川端豊, 原知也, 高島啓, 坂東美佳, 坂東左知子, 松浦朋美, 伊勢孝之, 仁木敏之, 上田由佳, 八木秀介, 岩瀬俊, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
治療方針に苦慮したDIC・多臓器不全合併コレステロール血晶塞栓症の一例,
第102回日本循環器学会中国・四国合同地方会, 2013年5月. 太田理絵, 山口浩司, 門田宗之, 川端豊, 原知也, 高島啓, 坂東美佳, 坂東左知子, 松浦朋美, 伊勢孝之, 仁木敏之, 上田由佳, 八木秀介, 岩瀬俊, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 坂東正章, 佐田政隆 :
治療方法選択に難渋した肺動静脈瘻合併右肺動脈上行大動脈起始症の一例,
第102回日本循環器学会中国・四国合同地方会, 2013年5月. 坂東美佳, 山田博胤, 仁木敏之, 山口浩司, 發知淳子, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 佐田政隆 :
心エコードプラ検査と心臓カテーテル検査で圧較差に乖離を認めた大動脈弁狭窄症の2例,
第102回日本循環器学会中国・四国合同地方会, 2013年5月. 羽星辰哉, 門田宗之, 發知淳子, 竹谷善雄, 神原保, 川端豊, 原知也, 高島啓, 坂東美佳, 坂東左知子, 松浦朋美, 伊勢孝之, 仁木敏之, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 北川哲也, 佐田政隆 :
プロテインC欠損に心房細動および低左心機能を合併した左室・右房内血栓の一例,
第102回日本循環器学会中国・四国合同地方会, 2013年5月. 門田宗之, 伊勢孝之, 八木秀介, 岩瀬俊, 太田理絵, 小笠原梢, 川端豊, 原知也, 坂東美佳, 坂東左知子, 松浦朋美, 發知淳子, 仁木敏之, 山口浩司, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
トルバプタンが効果を示したEisenmenger症候群に伴う高度右心不全の一例,
第102回日本循環器学会中国・四国合同地方会, 2013年5月. 高木恵理, 太田理絵, 仁木敏之, 門田宗之, 川端豊, 原知也, 高島啓, 坂東美佳, 坂東左知子, 松浦朋美, 伊勢孝之, 上田由佳, 山口浩司, 八木秀介, 岩瀬俊, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
妊娠中に静脈血栓症を発症し診断されたATⅢ欠損症合併妊娠の一例,
第102回日本循環器学会中国・四国合同地方会, 2013年5月. 山中森晶, 坂東左知子, 山口浩司, 西尾進, 太田理絵, 添木武, 松浦朋美, 門田宗之, 川端豊, 原知也, 高島啓, 坂東美佳, 伊勢孝之, 仁木敏之, 發知淳子, 上田由佳, 冨田紀子, 山口浩司, 八木秀介, 岩瀬俊, 竹谷善雄, 山田博胤, 若槻哲三, 四宮秀美, 佐田政隆 :
永久ペースメーカー植え込み後に偶発的に見つかった内頸静脈血栓の一例,
第102回日本循環器学会中国・四国合同地方会, 2013年5月. 高島啓, 島袋充生, 田端実, 植田初江, 植松悦子, 太田理絵, 門田宗之, 川端豊, 原知也, 坂東美佳, 坂東左知子, 松浦朋美, 仁木敏之, 伊勢孝之, 發知淳子, 上田由佳, 冨田紀子, 山口浩司, 福田大受, 八木秀介, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 高梨秀一郎, 佐田政隆 :
冠動脈内ステント内再狭窄4症例の病理組織学的検討,
第102回日本循環器学会中国・四国合同地方会, 2013年5月. 伊勢孝之, 岩瀬俊, 山田博胤, 川端豊, 門田宗之, 仁木敏之, 坂東美佳, 坂東左知子, 松浦朋美, 山口浩司, 八木秀介, 竹谷善雄, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
心病変の経過を観察し得たBecker型筋ジストロフィーによる心不全の1例,
第102回日本循環器学会中国・四国合同地方会, 2013年5月. 坂東左知子, 添木武, 門田宗之, 川端豊, 原知也, 高島啓, 坂東美佳, 松浦朋美, 伊勢孝之, 仁木敏之, 發知淳子, 上田由佳, 山口浩司, 八木秀介, 岩瀬俊, 竹谷善雄, 山田博胤, 若槻哲三, 石本武男, 佐田政隆 :
AVN dual pathwayにより頻拍周期が一心拍ごとに変化下Orthodromic AVRTの一例,
第102回日本循環器学会中国・四国合同地方会, 2013年5月. 松浦朋美, 添木武, 伊勢孝之, 仁木敏之, 發知淳子, 上田由佳, 冨田紀子, 山口浩司, 八木秀介, 竹谷善雄, 岩瀬俊, 山田博胤, 若槻哲三, 佐田政隆 :
通電により電動特性が変化した副伝導路の一例,
第102回日本循環器学会中国・四国合同地方会, 2013年5月. 發知淳子, 山田博胤, 西尾進, 坂東美佳, 林修司, 冨田紀子, 太田理絵, 門田宗之, 川端豊, 原知也, 高島啓, 坂東左知子, 松浦朋美, 伊勢孝之, 仁木敏之, 上田由佳, 山口浩司, 八木秀介, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 佐田政隆 :
運動誘発性肺高血圧を有する膠原病例における右室機能の検討,
第102回日本循環器学会中国・四国合同地方会, 2013年5月. 伊勢孝之, 八木秀介, 岩瀬俊, 門田宗之, 仁木敏之, 坂東美佳, 坂東左知子, 松浦朋美, 山口浩司, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
慢性心不全におけるAdaptive-Servo Ventilationの血行動態に対する効果,
第102回日本循環器学会中国・四国合同地方会, 2013年5月. T Matsuura, Takeshi Soeki, S Bando, T Hara, M Kadota, Y Kawabata, Mika Bando, J Hotchi, N Tomita, Yuka Ueda, Toshiyuki Niki, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
A Renin Inhibitor Prevents Atrial Endocardial Dysfunction in Rapidly Paced Rats with Streptozotocin-induced Diabetes.,
第77回日本循環器学会学術集会, Mar. 2013. Takayuki Ise, Shusuke Yagi, Masashi Akaike, Takashi Iwase, M Kadota, R Ota, Y Kawabata, T Hara, K Ogasawara, Mika Bando, S Bando, T Matsuura, Toshiyuki Niki, J Hotchi, Koji Yamaguchi, Yoshio Taketani, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Adaptive Servo-Ventilation Improves Symptoms and Hemodynamics in Both Patients with Systolic and Diastolic Heart Failure.,
第77回日本循環器学会学術集会, Mar. 2013. Koji Yamaguchi, Takeshi Soeki, Tetsuzo Wakatsuki, Toshiyuki Niki, Yoshio Taketani, R Ota, M Kadota, Y Kawabata, T Hara, Mika Bando, S Bando, T Matsuura, Takayuki Ise, J Hotchi, Yuka Ueda, Takashi Iwase, N Tomita, Hirotsugu Yamada and Masataka Sata :
Impact of Indoxyl Sulfate, a Uremic Toxin, on Non-Culprit Coronary Plaque Composition Assessed by Integrated Backscatter Intravascular Ultrasound.,
第77回日本循環器学会学術集会, Mar. 2013. Takayuki Ise, Takashi Iwase, Shoichiro Takao, M Kadota, Mika Bando, S Bando, T Matsuura, Toshiyuki Niki, J Hotchi, Shusuke Yagi, Koji Yamaguchi, Yoshio Taketani, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike, Masafumi Harada and Masataka Sata :
Evaluation of Right Ventricular Hypertrophy by Cardiac Magnetic Resonance is Useful for Detecting Cardiac Amyloidosis.,
第77回日本循環器学会学術集会, Mar. 2013. Koji Yamaguchi, Tetsuzo Wakatsuki, Toshiyuki Niki, Yoshio Taketani, R Ota, M Kadota, Y Kawabata, T Hara, Mika Bando, S Bando, T Matsuura, Takayuki Ise, J Hotchi, Yuka Ueda, Takashi Iwase, N Tomita, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Differential Responses of Local Coagulation after Implantation of Everolimus-Eluting Stent Compared with Early-Generation Drug-Eluting Stents.,
第77回日本循環器学会学術集会, Mar. 2013. Shusuke Yagi, Takayuki Ise, Hirotsugu Yamada, S Nishio, Yuka Ueda, Takashi Iwase, Toshiyuki Niki, Koji Yamaguchi, Yoshio Taketani, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Ratio of Eicosapentaenoic Acid to Arachidonic Acid is a Predictive Factor of Albuminuria and Endothelial Function in Patients with Dyslipidemia.,
第77回日本循環器学会学術集会, Mar. 2013. Takashi Iwase, Shoichiro Takao, Masashi Akaike, Takayuki Ise, Toshiyuki Niki, Yuka Ueda, Koji Yamaguchi, Yoshio Taketani, Hirotsugu Yamada, Takeshi Soeki, Ken-ichi Aihara, Tetsuzo Wakatsuki, Yasuhiko Nishioka, Masafumi Harada and Masataka Sata :
Differentiation of Left Ventricular Systolic Dysfunction Related to Cardiac Sarcoidosis and Other Heart Diseases Using contrast-enhanced Cardiovascular Magnetic Resonance.,
第77回日本循環器学会学術集会, Mar. 2013. M Kadota, Takayuki Ise, Shusuke Yagi, Takashi Iwase, Masashi Akaike, R Ota, Y Kawabata, T Hara, K Ogasawara, Mika Bando, S Bando, T Matsuura, Toshiyuki Niki, J Hotchi, Koji Yamaguchi, Yoshio Taketani, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Effects of Tolvaptan are Predicted by Vasopressin/Aldosterone Ratio and Urine Osmolality in Patients with Chronic Heart Failure.,
第77回日本循環器学会学術集会, Mar. 2013. Toshiyuki Niki, Tetsuzo Wakatsuki, Mika Bando, Koji Yamaguchi, Yoshio Taketani, R Ota, Y Kawabata, M Kadota, T Hara, Mika Bando, Takayuki Ise, T Matsuura, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Effects of Additional Eicosapentaenoic Acid Therapy on Inflammatory Cytokines and Atherosclerotic Plaque Component Assessed by Integrated Backscatter Ultrasound Systems.,
第77回日本循環器学会学術集会, Mar. 2013. 添木武, S Bando, T Matsuura, T Hara, R Ota, Y Kawabata, 坂東美佳, J Hotchi, N Tomita, 上田由佳, 仁木敏之, 伊勢孝之, 山口浩司, 八木秀介, 福田大受, 竹谷善雄, 岩瀬俊, 山田博胤, 若槻哲三, 島袋充生, 佐田政隆 :
Pentraxin 3 is a Local Inflammatory Marker in Atrial Fibrillation.,
第77回日本循環器学会学術集会, 2013年3月. Mika Bando, Hirotsugu Yamada, S Nishio, N Tomita, J Hotchi, S Hayashi, K Ogasawara, A Takashima, S Bando, Takayuki Ise, Toshiyuki Niki, T Matsuura, Yuka Ueda, Koji Yamaguchi, Shusuke Yagi, Takashi Iwase, Yoshio Taketani, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Effect of Eicosapentaenoic Acid on the Stabilization of Vulnerability in Carotid Artery Plaque: Evaluation Using iPlaque® Software.,
第77回日本循環器学会学術集会, Mar. 2013. S Bando, Daiju Fukuda, Takeshi Soeki, E Uematsu, H Sato, A Takashima, Mika Bando, T Matsuura, Toshiyuki Niki, Takayuki Ise, J Hotchi, Yuka Ueda, N Tomita, Koji Yamaguchi, Yoshio Taketani, Takashi Iwase, Shusuke Yagi, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Relationship between NLRP3 Inflammasome Activation in Adipose Tissue and Atherosclerosis.,
第77回日本循環器学会学術集会, Mar. 2013. Takeshi Soeki, Koji Yamaguchi, Toshiyuki Niki, R Ota, T Hara, M Kadota, Mika Bando, S Bando, T Matsuura, J Hotchi, N Tomita, Yuka Ueda, Takayuki Ise, Shusuke Yagi, Daiju Fukuda, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Cardiospecific microRNA Plasma Levels are Associated With Coronary Plaque Vulnerability.,
第77回日本循環器学会学術集会, Mar. 2013. E Takagi, R Ota, 仁木敏之, M Kadota, Y Kawabata, T Hara, A Takashima, 坂東美佳, S Bando, T Matsuura, 伊勢孝之, J Hotchi, 上田由佳, 山口浩司, 八木秀介, 岩瀬俊, 竹谷善雄, N Tomita, 山田博胤, 添木武, 若槻哲三, 佐田政隆, 中山聡一朗, 前田和寿, 苛原稔 :
妊娠を契機にATⅢ欠損症と診断され，血栓管理の後に出産に至った一例,
第246回徳島医学会学術集会(平成24年度冬期), 2013年2月. T Haboshi, M Kadota, J Hotchi, 竹谷善雄, T Matsuura, 伊勢孝之, 仁木敏之, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 佐田政隆, 木下肇, 神原保, 北川哲也, 古本博孝, 髙橋久弥 :
プロテインC欠損に心房細動および低左心機能を合併した左室・右房内血栓の一例,
第246回徳島医学会学術集会(平成24年度冬期), 2013年2月. S Sakamoto, M Kadota, 伊勢孝之, 岩瀬俊, S Bando, T Matsuura, 仁木敏之, J Hotchi, N Tomita, 上田由佳, 山口浩司, 八木秀介, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 佐田政隆, 赤池雅史, M Takeuchi :
再熱と寛解を繰り返す特発性心膜炎に対しイブプロフェンが有効であった1例,
第246回徳島医学会学術集会(平成24年度冬期), 2013年2月. K Ota, 仁木敏之, R Ota, Y Kawabata, M Kadota, T Hara, A Takashima, 坂東美佳, S Bando, T Matsuura, 伊勢孝之, J Hotchi, 上田由佳, 山口浩司, 八木秀介, 岩瀬俊, 竹谷善雄, N Tomita, 山田博胤, 添木武, 若槻哲三, 佐田政隆, J Shunto :
偶発的に発見された末梢動脈閉塞の二例,
第246回徳島医学会学術集会(平成24年度冬期), 2013年2月. M Koda, 佐田政隆, 伊勢孝之, Y Kawabata, 岩瀬俊, M Kadota, T Hara, R Ota, 坂東美佳, S Bando, T Matsuura, 仁木敏之, J Hotchi, N Tomita, 上田由佳, 山口浩司, 八木秀介, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, S Okazaki, 林友鴻, T Hasegawa :
難治性の閉塞性肥大型心筋症に対して経皮的中隔心筋焼灼術が著効した1例,
第246回徳島医学会学術集会(平成24年度冬期), 2013年2月. R Ota, 山口浩司, M Kadota, Y Kawabata, T Hara, A Takashima, 坂東美佳, S Bando, T Matsuura, 伊勢孝之, 仁木敏之, J Hotchi, 上田由佳, 八木秀介, 岩瀬俊, 竹谷善雄, N Tomita, 山田博胤, 添木武, 若槻哲三, 佐田政隆, 髙尾正一郎, 原田雅史, M Bando :
41歳まで無症状で経過した肺動静脈瘻合併右肺動脈上行大動脈起始症の一例,
第246回徳島医学会学術集会(平成24年度冬期), 2013年2月. 坂東美佳, 山田博胤, S Nishio, R Tamai, Y Hirata, N Tomita, J Hotchi, S Hayashi, M Nakagawa, D Hirota, A Takashima, 伊勢孝之, 仁木敏之, 山口浩司, 福田大受, 八木秀介, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 佐田政隆 :
イコサペント酸エチルは頸動脈プラークの安定化に寄与する:iPlaque®を用いた検討,
第101回日本循環器学会四国地方会, 2012年12月. 上田由佳, 伊勢孝之, 岩瀬俊, K Maeda, K Nishikawa, M Kadota, T Hara, Y Kawabata, R Ota, 仁木敏之, 山口浩司, 八木秀介, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 加藤真介, 安井夏生, 佐田政隆 :
心臓リハビリテーションにおける禁煙継続効果の検討,
第101回日本循環器学会四国地方会, 2012年12月. Y Kawabata, 伊勢孝之, T Matsuura, S Bando, 岩瀬俊, K Ogasawara, 坂東美佳, 仁木敏之, J Hotchi, N Tomita, 上田由佳, 山口浩司, 八木秀介, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
高度肥満を伴った拡張型心筋症の1例,
第101回日本循環器学会四国地方会, 2012年12月. R Ota, 仁木敏之, 竹谷善雄, M Kadota, Y Kawabata, T Hara, 坂東美佳, S Bando, T Matsuura, 伊勢孝之, J Hotchi, 上田由佳, 山口浩司, 岩瀬俊, N Tomita, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
カテーテル的血栓吸引・血栓溶解療法が奏功し，心肺停止状態から救命できた院内発症急性肺血栓塞栓症の一例,
第101回日本循環器学会四国地方会, 2012年12月. M Nakagawa, 山田博胤, S Nishio, N Tomita, J Hotchi, S Hayashi, 坂東美佳, R Tamai, Y Hirata, D Hirota, S Yasuoka, K Yokokura, 仁木敏之, 伊勢孝之, 山口浩司, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 佐田政隆 :
心房細動例における拡張中期僧帽弁口血流速波高は左室充満圧を反映する,
第101回日本循環器学会四国地方会, 2012年12月. S Sakamoto, M Kadota, 伊勢孝之, 岩瀬俊, S Bando, T Matsuura, 仁木敏之, J Hotchi, N Tomita, 上田由佳, 山口浩司, 八木秀介, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
再燃と寛解を繰り返す特発性心膜炎に対しイブプロフェンが有効であった1例,
第101回日本循環器学会四国地方会, 2012年12月. N Kobayashi, T Hara, 山口浩司, K Ogasawara, 坂東美佳, S Bando, T Matsuura, J Hotchi, N Tomita, 伊勢孝之, 仁木敏之, 上田由佳, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, M Bando, 佐田政隆 :
多彩な血圧変動素因により顕著な夜間血圧を認めた一例,
第101回日本循環器学会四国地方会, 2012年12月. S Yasuoka, 山田博胤, K Yokokura, Y Hirata, D Hirota, R Tamai, M Nakagawa, S Nishio, 坂東美佳, J Hotchi, S Hayashi, N Tomita, 伊勢孝之, 仁木敏之, 山口浩司, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 佐田政隆 :
当院におけるたこつぼ型心筋症の臨床的特徴,
第101回日本循環器学会四国地方会, 2012年12月. K Yokokura, 山田博胤, S Yasuoka, Y Hirata, D Hirota, R Tamai, M Nakagawa, S Nishio, 坂東美佳, J Hotchi, S Hayashi, N Tomita, 仁木敏之, 山口浩司, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 佐田政隆 :
心エコー法を用いた平均右房圧推定法の検証,
第101回日本循環器学会四国地方会, 2012年12月. T Hara, 山口浩司, 岩瀬俊, M Kadota, K Ogasawara, 坂東美佳, S Bando, T Matsuura, J Hotchi, N Tomita, 伊勢孝之, 仁木敏之, 上田由佳, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, S Orino, 佐田政隆 :
Churg-Strauss症候群に合併した好酸球性心筋炎の一例,
第101回日本循環器学会四国地方会, 2012年12月. Mika Bando, Hirotsugu Yamada, S Nishio, R Tamai, Y Hirata, D Hirota, M Nakagawa, S Hayashi, N Tomita, J Hotchi, Toshiyuki Niki, Koji Yamaguchi, Daiju Fukuda, Shusuke Yagi, Takashi Iwase, Yoshio Taketani, Takeshi Soeki, Tetsuzo Wakatsuki, Shinji Nagahiro and Masataka Sata :
Effect of EPA of Carotid Artery Plaque Assessed by Integrated Backscatter Mapping : Development of imaging analytical software.,
第20回日本血管生物医学会学術集会, Dec. 2012. Koji Yamaguchi, Tetsuzo Wakatsuki, Toshiyuki Niki, Yoshio Taketani, H Oezuka, R Ota, Y Kawabata, T Hara, M Kadota, K Ogasawara, S Bando, T Matuura, J Hotchi, Takayuki Ise, Shusuke Yagi, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Telmisartan reduces local inflammatory response and coronary plaque vulnerability assessed by integrated backscatter intravascular ultrasound in hypertensive patients.,
第20回日本血管生物医学会学術集会, Dec. 2012. Y Yokota, S Bando, 添木武, M Kadota, T Matsuura, 山田博胤, 若槻哲三, 佐田政隆, H Yoshida, T Ishimoto :
AVN dual pathwayにより頻拍周期が1心拍ごとに変化したOrthodromic AVRTの1例,
第107回日本内科学会四国地方会, 2012年12月. M Miyauchi, T Matsuura, 上田由佳, 山口浩司, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
心臓粗動を契機として右心不全を発症し，左房還流型PLSVCとunroofed CSの合併が判明した1例,
第107回日本内科学会四国地方会, 2012年12月. M Kadota, Takayuki Ise, Takashi Iwase, Masashi Akaike, Koji Yamaguchi, Yoshio Taketani, Hirotsugu Yamada, Tetsuzo Wakatsuki, Takeshi Soeki and Masataka Sata :
Prediction of Responder and Influence for Cardio-Renal Interaction by Tolvaptan in Patients with Chronic Heart Failure.,
第16回日本心不全学会学術集会, Nov. 2012. Takayuki Ise, Shusuke Yagi, Masashi Akaike, Takashi Iwase, M Kadota, T Hara, Koji Yamaguchi, Yoshio Taketani, Tetsuzo Wakatsuki and Masataka Sata :
Acute Hemodynamic Effects of Adaptive Servo-Ventilation in Patients with Chronic Heart Failure.,
第16回日本心不全学会学術集会, Nov. 2012. 仁木敏之, 若槻哲三, 坂東美佳, 西尾進, 小笠原梢, 坂東左知子, 伊勢孝之, 發知淳子, 山口浩司, 竹谷善雄, 岩瀬俊, 冨田紀子, 山田博胤, 添木武, 佐田政隆 :
スタチンへのEPA製剤追加による動脈硬化病変の組織性状変化に関する検討,
第60回日本心臓病学会学術集会, 2012年9月. Y Hirata, T Hara, 山田博胤, S Nishio, D Hirota, R Tamai, M Nakagawa, 坂東美佳, J Hotchi, N Tomita, S Hayashi, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 佐田政隆 :
心膜内膿瘍を合併した収縮性心膜炎の一例,
第60回日本心臓病学会学術集会, 2012年9月. S Bando, 添木武, 伊勢孝之, 岩瀬俊, T Hara, M Kadota, 坂東美佳, K Ogasawara, J Hotchi, N Tomita, 仁木敏之, 山口浩司, 竹谷善雄, 山田博胤, 若槻哲三, 佐田政隆 :
心房周囲炎症と心囊液貯留により収縮性心膜炎の病態を呈した一例,
第60回日本心臓病学会学術集会, 2012年9月. J Hotchi, 山田博胤, S Nishio, 坂東美佳, S Hayashi, N Tomita, Y Hirata, D Hirota, R Tamai, M Nakagawa, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 佐田政隆 :
安静時に肺高血圧を呈さない膠原病例における心エコー・ドプラ法を用いた右室機能不全の評価,
第60回日本心臓病学会学術集会, 2012年9月. 山口浩司, 若槻哲三, 仁木敏之, 竹谷善雄, S Bando, 伊勢孝之, 岩瀬俊, 山田博胤, 添木武, 佐田政隆 :
シロリムス溶出ステント留置後における局所血管反応の検討-局所バイオマーカーとperi-contrast stainingの観点から-,
第60回日本心臓病学会学術集会, 2012年9月. S Hayashi, 山田博胤, N Tomita, J Hotchi, 坂東美佳, S Nishio, R Tamai, M Nakagawa, D Hirota, Y Hirata, 山口浩司, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 佐田政隆 :
僧帽弁口血流速波系が偽正常化パターンを示す左室駆出率が保持された心不全(HFPEF)と左房機能不全の鑑別,
第60回日本心臓病学会学術集会, 2012年9月. 伊勢孝之, 岩瀬俊, K Nanjo, 髙尾正一郎, R Ota, S Bando, 仁木敏之, 上田由佳, 山口浩司, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 原田雅史, 佐田政隆 :
心臓MRIを用いた左室肥大患者における右室壁厚の検討,
第60回日本心臓病学会学術集会, 2012年9月. 添木武, 山口浩司, 仁木敏之, K Ogasawara, 坂東美佳, S Bando, T Matsuura, N Tomita, 上田由佳, 伊勢孝之, 竹谷善雄, 岩瀬俊, 山田博胤, 若槻哲三, 島袋充生, 佐田政隆 :
血中micro RNAは冠動脈不安定プラークのバイオマーカーになりえるか?,
第60回日本心臓病学会学術集会, 2012年9月. S Bando, 添木武, T Matsuura, 坂東美佳, K Ogasawara, J Hotchi, N Tomita, 伊勢孝之, 仁木敏之, 山口浩司, 竹谷善雄, 岩瀬俊, 山田博胤, 若槻哲三, 島袋充生, 佐田政隆 :
NLRPインフラマソームと冠動脈硬化の関連について,
第60回日本心臓病学会学術集会, 2012年9月. 坂東美佳, 山田博胤, S Nishio, N Tomita, J Hotchi, R Tamai, M Nakagawa, D Hirota, Y Hirata, S Hayashi, K Ogasawara, 仁木敏之, 山口浩司, 添木武, 若槻哲三, 佐田政隆 :
重症大動脈弁狭窄症を呈した成人大動脈一尖弁の2例,
第60回日本心臓病学会学術集会, 2012年9月. 若槻哲三, 仁木敏之, 山口浩司, 伊勢孝之, 岩瀬俊, 竹谷善雄, 山田博胤, 添木武, 佐田政隆 :
OCTにてneovascularizationを認めた冠動脈プラークのIB-IVUSによる組織性状の評価,
第60回日本心臓病学会学術集会, 2012年9月. S Nishio, 山田博胤, M Sato, H Hiraoka, Y Hirata, D Hirota, 坂東美佳, S Hayashi, J Hotchi, N Tomita, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 佐田政隆 :
糖尿病において左房容積係数と最も相関する非侵襲的血管検査指標は何か:左房-左室-血管連関についての検討,
第60回日本心臓病学会学術集会, 2012年9月. 仁木敏之, 若槻哲三, 坂東美佳, S Nishio, K Ogasawara, S Bando, 伊勢孝之, J Hotchi, 山口浩司, 竹谷善雄, 岩瀬俊, N Tomita, H Yamada, 添木武, 佐田政隆 :
スタチンへのEPA製剤追加による動脈硬化病変の組織性状変化に関する検討,
第60回日本心臓病学会学術集会, 2012年9月. 仁木敏之, 若槻哲三, K Ogasawara, 伊勢孝之, 山口浩司, 竹谷善雄, 岩瀬俊, 佐田政隆 :
Neovascularizationを認めた冠動脈プラークの組織性状の評価-OCTおよびIB-IVUS所見の比較検討-,
第19回日本心血管インターベンション治療学会中国・四国地方会, 2012年9月. Y Yokota, M Kadota, 伊勢孝之, 岩瀬俊, T Hara, R Ota, Y Kawabata, K Ogasawara, 坂東美佳, S Bando, T Matsuura, 仁木敏之, J Hotchi, N Tomita, 上田由佳, 山口浩司, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 佐田政隆, 赤池雅史, 江川麻理子, 三田村佳典 :
眼病変の経過中に心室中隔の肥厚および完全房室ブロックで発症した心サルコイドーシスの一例,
第245回徳島医学会学術集会(平成24年度夏期), 2012年7月. N Kawano, 仁木敏之, K Ogasawara, R Ota, M Kadota, Y Kawabata, T Hara, 伊勢孝之, T Matsuura, 上田由佳, 山口浩司, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 佐田政隆, T Yamamoto, K Kawano, 角谷明佳, K Seto, 金山博臣 :
シスプラチン，エトポシド，ブレオマイシンの三剤化学療法併用中に急性心筋梗塞を発症した二例,
第245回徳島医学会学術集会(平成24年度夏期), 2012年7月. K Matsumoto, 仁木敏之, K Ogasawara, R Ota, M Kadota, Y Kawabata, T Hara, 伊勢孝之, T Matsuura, 上田由佳, 山口浩司, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 佐田政隆, Y Sawa :
プロテインC活性低下を背景とし，オートマチック車への変更を契機に肺血栓塞栓症を発症したタクシー運転手の一例,
第245回徳島医学会学術集会(平成24年度夏期), 2012年7月. N Kobayashi, T Hara, 山口浩司, M Kadota, R Ota, Y Kawabata, K Ogasawara, 坂東美佳, S Bando, T Matsuura, J Hotchi, N Tomita, 伊勢孝之, 仁木敏之, 上田由佳, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 佐田政隆, M Bando :
著名な自立神経障害を背景とした治療抵抗性夜間高血圧症の一例,
第245回徳島医学会学術集会(平成24年度夏期), 2012年7月. 上田由佳, 岩瀬俊, 伊勢孝之, K Maeda, K Nishikawa, 坂東美佳, K Ogasawara, S Bando, 仁木敏之, J Hotchi, 山口浩司, N Tomita, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 加藤真介, 安井夏生, 佐田政隆 :
喫煙継続者における心臓リハビリテーションの効果の検討,
第18回心臓リハビリテーション学会, 2012年7月. K Maeda, 上田由佳, 伊勢孝之, 岩瀬俊, K Nishikawa, 坂東美佳, K Ogasawara, S Bando, 仁木敏之, J Hotchi, 山口浩司, N Tomita, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 加藤真介, 安井夏生, 佐田政隆 :
患者の気持ちを汲んだ患者教育の実際,
第18回心臓リハビリテーション学会, 2012年7月. A Takashima, 伊勢孝之, 上田由佳, K Maeda, K Nishikawa, K Ogasawara, 坂東美佳, N Tomita, 仁木敏之, J Hotchi, 山口浩司, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 加藤真介, 赤池雅史, 安井夏生, 佐田政隆 :
心臓リハビリテーションは酸化LDLを低下させる,
第18回心臓リハビリテーション学会, 2012年7月. 仁木敏之, 若槻哲三, 山口浩司, 竹谷善雄, 岩瀬俊, 佐田政隆 :
The Tissue characteristics of coronary plaque with microchannel structure in patients with coronary artery disease assessed by OCT and IB-IVUS,
第21回日本心血管インターベンション治療学会学術集会, 2012年7月. Koji Yamaguchi, Tetsuzo Wakatsuki, Toshiyuki Niki, Yoshio Taketani, Takashi Iwase and Masataka Sata :
Local Coagulative Response after Zotarolimus-eluting, Sirolimus-eluting and Bare-metal Stents Implantation in the Chronic Phase.,
第21回日本心血管インターベンション治療学会学術集会, Jul. 2012. S Bando, 添木武, 伊勢孝之, 岩瀬俊, 坂東美佳, K Ogasawara, J Hotchi, N Tomita, 仁木敏之, 山口浩司, 竹谷善雄, 山田博胤, 若槻哲三, 菅野幹雄, 神原保, 北川哲也, 佐田政隆 :
心房周囲炎症と心囊液貯留により収縮性心膜炎の病態を呈した一例,
第100回日本循環器学会中国・四国合同地方会, 2012年6月. A Tachibana, 伊勢孝之, 添木武, 岩瀬俊, R Ota, M Kadota, T Hara, 坂東美佳, K Ogasawara, S Bando, 仁木敏之, J Hotchi, N Tomita, 上田由佳, 山口浩司, 竹谷善雄, 山田博胤, 若槻哲三, 赤池雅史, 佐田政隆 :
CRT-Dが著効した重症拡張型心筋症の2症例,
第100回日本循環器学会中国・四国合同地方会, 2012年6月. S Nagasaka, 伊勢孝之, 岩瀬俊, R Ota, M Kadota, T Hara, 坂東美佳, K Ogasawara, S Bando, 仁木敏之, J Hotchi, N Tomita, 上田由佳, 山口浩司, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
マルチモダリティを用いて鑑別し得た冠動脈病変合併たこつぼ型心筋症の1症例,
第100回日本循環器学会中国・四国合同地方会, 2012年6月. 伊勢孝之, K Nanjo, 岩瀬俊, 髙尾正一郎, R Ota, M Kadota, T Hara, 坂東美佳, K Ogasawara, S Bando, 仁木敏之, 上田由佳, 山口浩司, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 原田雅史, 佐田政隆 :
左室肥大患者における右室壁厚の検討,
第100回日本循環器学会中国・四国合同地方会, 2012年6月. J Hotchi, S Taoka, 坂東美佳, K Ogasawara, A Takashima, H Yamasaki, S Bando, 伊勢孝之, 仁木敏之, 山口浩司, 上田由佳, N Tomita, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, Y Saijo, 佐田政隆 :
緊密な病診連携と詳細な副腎静脈サンプリングが迅速な根治術につながった原発性アルドステロン症の一例,
第100回日本循環器学会中国・四国合同地方会, 2012年6月. 伊勢孝之, 岩瀬俊, R Ota, M Kadota, T Hara, A Takashima, H Yamasaki, 坂東美佳, K Ogasawara, S Bando, 仁木敏之, J Hotchi, N Tomita, 上田由佳, 山口浩司, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
Adaptive Servo-Ventilationが心不全治療に有効であった心アミロイドーシスの2症例,
第100回日本循環器学会中国・四国合同地方会, 2012年6月. K Maeda, 上田由佳, 伊勢孝之, 岩瀬俊, K Nishikawa, 坂東美佳, K Ogasawara, S Bando, 仁木敏之, J Hotchi, 山口浩司, N Tomita, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 加藤真介, 安井夏生, 佐田政隆 :
チーム医療で取り組む重症心不全に対する心臓リハビリテーション,
第100回日本循環器学会中国・四国合同地方会, 2012年6月. S Taoka, 伊勢孝之, 岩瀬俊, R Ota, M Kadota, T Hara, K Ogasawara, 坂東美佳, S Bando, 仁木敏之, J Hotchi, N Tomita, 上田由佳, 山口浩司, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
テニスラケットによる打撲が誘引で深部静脈血栓・急性肺塞栓症を来した1症例,
第100回日本循環器学会中国・四国合同地方会, 2012年6月. K Ogasawara, 仁木敏之, 坂東美佳, S Bando, 伊勢孝之, J Hotchi, 上田由佳, 山口浩司, 岩瀬俊, 竹谷善雄, N Tomita, 山田博胤, 添木武, 若槻哲三, 島袋充生, 佐田政隆 :
永久型下大静脈フィルター血栓閉塞に対し抗凝固療法を中心とした保存的加療が有効であった2症例,
第100回日本循環器学会中国・四国合同地方会, 2012年6月. 坂東美佳, 山田博胤, K Ogasawara, 仁木敏之, N Tomita, J Hotchi, R Tamai, Y Hirata, D Hirota, S Nishio, S Bando, 伊勢孝之, 上田由佳, 山口浩司, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 佐田政隆, H Kawano, 西岡安彦 :
肺動脈血栓に対してフォンダパリヌクスが著効した静脈血栓塞栓症の一例,
第100回日本循環器学会中国・四国合同地方会, 2012年6月. R Tamai, 坂東美佳, 山田博胤, S Nishio, N Tomita, J Hotchi, S Hayashi, M Nakagawa, Y Hirata, D Hirota, K Ogasawara, H Yamasaki, S Bando, 伊勢孝之, 仁木敏之, 山口浩司, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 佐田政隆 :
超音波後方散乱信号を用いたカラーマッピングシステムの脂質低下療法における臨床応用:case report,
第100回日本循環器学会中国・四国合同地方会, 2012年6月. Y Oguro, 仁木敏之, K Ogasawara, 坂東美佳, S Bando, 伊勢孝之, J Hotchi, 上田由佳, 山口浩司, 竹谷善雄, 岩瀬俊, N Tomita, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
マニュアル車からオートマチック車に変更後に左下肢深部静脈血栓症を生じたタクシー運転手の一例,
第100回日本循環器学会中国・四国合同地方会, 2012年6月. 森住俊, J Hotchi, 山田博胤, 坂東美佳, H Yamasaki, K Ogasawara, K Takashima, S Bando, 伊勢孝之, 仁木敏之, 山口浩司, N Tomita, 上田由佳, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 佐田政隆 :
完全房室ブロックを合併して恒久的ペースメーカー植込みを必要としたたこつぼ型心筋症の一症例,
第100回日本循環器学会中国・四国合同地方会, 2012年6月. N Kawano, 仁木敏之, K Ogasawara, 坂東美佳, S Bando, 伊勢孝之, J Hotchi, 上田由佳, 山口浩司, 竹谷善雄, 岩瀬俊, N Tomita, 山田博胤, 添木武, 若槻哲三, T Yamamoto, K Kawano, 角谷明佳, 佐田政隆 :
シスプラチン，エトポシド，ブレオマイシンの三剤化学療法併用中に急性心筋梗塞を発症した二例,
第100回日本循環器学会中国・四国合同地方会, 2012年6月. 山口浩司, 若槻哲三, 添木武, 仁木敏之, 竹谷善雄, H Oezuka, K Ogasawara, 坂東美佳, S Bando, J Hotchi, 上田由佳, N Sakamoto, 伊勢孝之, 岩瀬俊, 山田博胤, 佐田政隆 :
テルミサルタンの冠動脈プラークに対する抗動脈硬化作用の検討,
第100回日本循環器学会中国・四国合同地方会, 2012年6月. S Hayashi, M Sato, 山田博胤, N Tomita, J Hotchi, 坂東美佳, S Nishio, R Tamai, M Nakagawa, D Hirota, Y Hirata, 伊勢孝之, 仁木敏之, 山口浩司, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 佐田政隆 :
僧帽弁輪運動速波形指標およびAugmentation Indenxの性差と相互連関についての検討,
第23回日本心エコー図学会学術集会, 2012年4月. Tomita Noriko, 山田博胤, 楠瀬賢也, Nishio Susumu, Hotchi Junko, Hayashi Shuji, 坂東美佳, Bando Sachiko, 伊勢孝之, 仁木敏之, 山口浩司, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 佐田政隆 :
Clinical Efficacy of Beat-to-beat Variability of Diastolic Filling in Atrial Fibrillation.,
第76回日本循環器学会学術集会, 2012年3月. Munkbaatar Dagvasumberel, 島袋充生, Nishiuchi Takeshi, Hirata Yoichiro, 添木武, 赤池雅史, 岩瀬俊, 楠瀬賢也, 仁木敏之, 山口浩司, 小柴邦彦, 竹谷善雄, 八木秀介, Tomita Noriko, 山田博胤, 若槻哲三, 黒部裕嗣, 北川哲也, 佐田政隆 :
Gender Disparities in Association of Epicardial Adipose Tissue Volume and Coronary Atherosclerosis.,
第76回日本循環器学会学術集会, 2012年3月. Bando Sachiko, Takeshi Soeki, Ogasawara Kozue, Takashima Akira, Mika Bando, Yamazaki Hiromu, Hotchi Junko, Tomita Noriko, Takayuki Ise, Toshiyuki Niki, Koji Yamaguchi, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Relationship between NLRP3 Inflammasome and Coronary Atherosclerosis.,
第76回日本循環器学会学術集会, Mar. 2012. Hotchi Junko, Hirotsugu Yamada, Kenya Kusunose, Nishio Susumu, Mika Bando, Tomita Noriko, Hayashi Shuji, Bando Sachiko, Toshiyuki Niki, Takayuki Ise, Koji Yamaguchi, Takashi Iwase, Yoshio Taketani, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Effect of Irbesartan on Left Ventricular Myocardial Function in Patients with Hypertension: Assessment by Two-dimensional Speckle Tracking Echocardiography.,
第76回日本循環器学会学術集会, Mar. 2012. Koji Yamaguchi, Tetsuzo Wakatsuki, Toshiyuki Niki, Yoshio Taketani, Bando Sachiko, Hotchi Junko, Tomita Noriko, Takayuki Ise, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Angiographic Peri-stent Contrast Staining Leading to Local Persistent Hypercoagulability up to Five Years after Sirolimus-eluting Stent Implantation:Comparison with Bare-Metal Stent.,
第76回日本循環器学会学術集会, Mar. 2012. Kimura Sahika, 上田由佳, 伊勢孝之, 岩瀬俊, Takashima Akira, Yamazaki Hiromu, Ogasawara Kozue, Bando Sachiko, Hayashi Shuji, Takeuchi Hidekazu, 仁木敏之, 楠瀬賢也, 山口浩司, Tomita Noriko, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
Cardiac Rehabilitation decreases Urinary Albumin Excretion in Patients with Cardiovascular Disease.,
第76回日本循環器学会学術集会, 2012年3月. Takashima Akira, Takayuki Ise, Takashi Iwase, Yuka Ueda, Masashi Akaike, Yamazaki Hiromu, Mika Bando, Ogasawara Kozue, Bando Sachiko, Tomita Noriko, Takeuchi Hidekazu, Toshiyuki Niki, Hotchi Junko, Koji Yamaguchi, Yoshio Taketani, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Effect of Cardiac Rehabilitation on Level of Oxidized LDL.,
第76回日本循環器学会学術集会, Mar. 2012. Hirotsugu Yamada, Tomita Noriko, Hayashi Shuji, Hotchi Junko, Nishio Susumu, Tamai Rina, Toshiyuki Niki, Koji Yamaguchi, Takashi Iwase, Yoshio Taketani, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Prognostic Value of Preload Stress Echocardiographyin Patients with Mild Heart Failure.,
第76回日本循環器学会学術集会, Mar. 2012. 添木武, 仁木敏之, 山口浩司, 坂東左知子, 上田由佳, 冨田紀子, 伊勢孝之, 楠瀬賢也, 竹谷善雄, 岩瀬俊, 山田博胤, 若槻哲三, 赤池雅史, 島袋充生, 佐田政隆 :
Inflammatory Biomarkers as Predictors of Vulnerable Coronary Plaques.,
第76回日本循環器学会学術集会，Symposium 3, 2012年3月. 山田博胤, 西尾進, 坂東美佳, 發知淳子, 林修司, 冨田紀子, 伊勢孝之, 仁木敏之, 山口浩司, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 佐田政隆 :
Carotid Ultrasound Imaging to Evaluate Atherosclerotic Diseases.,
第76回日本循環器学会学術集会，KSC-JCS Joint Symposium-2, 2012年3月. 立花綾香, 上田由佳, 伊勢孝之, 高島啓, 山崎宙, 小笠原梢, 坂東左知子, 仁木敏之, 發知淳子, 冨田紀子, 山口浩司, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 佐田政隆, 赤池雅史, 廣野明 :
CRT-Dが著効した重症慢性心不全の1例,
第244回徳島医学会学術集会 (平成23年度冬期), 2012年2月. 田岡志保, 上田由佳, 伊勢孝之, 高島啓, 山崎宙, 小笠原梢, 坂東左知子, 仁木敏之, 發知淳子, 冨田紀子, 山口浩司, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 佐田政隆, 赤池雅史, 井上洋行 :
テニスラケットによる外傷が誘因で深部静脈血栓・急性肺塞栓症を来した一症例,
第244回徳島医学会学術集会 (平成23年度冬期), 2012年2月. 森住俊, 發知淳子, 山田博胤, 山崎宙, 小笠原梢, 高島啓, 坂東美佳, 坂東左知子, 竹内秀和, 伊勢孝之, 仁木敏之, 山口浩司, 冨田紀子, 上田由佳, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 佐田政隆, 久保克之, 佐々木克哉, 富田芳雄 :
たこつぼ型心筋症に完全房室ブロックを合併した一症例,
第244回徳島医学会学術集会 (平成23年度冬期), 2012年2月. 坂東美佳, 山田博胤, 冨田紀子, 發知淳子, 小笠原梢, 高島啓, 山崎宙, 坂東左知子, 伊勢孝之, 仁木敏之, 上田由佳, 山口浩司, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 赤池雅史, 佐田政隆, 西尾進, 林修司, 中川摩耶, 玉井利奈, 平田有紀奈, 弘田大智 :
脂質低下療法による頸動脈プラーク安定化の評価:超音波integrated backscatterを用いたカラーマッピングシステムの臨床応用,
第244回徳島医学会学術集会 (平成23年度冬期), 2012年2月. 山口浩司, 若槻哲三, 添木武, 仁木敏之, 竹谷善雄, 小笠原梢, 坂東美佳, 坂東左知子, 發知淳子, 上田由佳, 冨田紀子, 竹内秀和, 伊勢孝之, 岩瀬俊, 山田博胤, 佐田政隆, 麻植塚浩康 :
テルミサルタンの冠動脈プラークに対する抗動脈硬化作用の検討,
第244回徳島医学会学術集会 (平成23年度冬期), 2012年2月. 仁木敏之, 小笠原梢, 坂東美佳, 坂東左知子, 竹内秀和, 伊勢孝之, 發知淳子, 上田由佳, 山口浩司, 岩瀬俊, 竹谷善雄, 冨田紀子, 山田博胤, 添木武, 若槻哲三, 佐田政隆, 中瀧恵実子, 西村匡司, 上山祐二 :
低体温療法が著効し社会復帰をなし得たBrugada症候群の一例,
第244回徳島医学会学術集会 (平成23年度冬期), 2012年2月. 太田理絵, 若槻哲三, 岩瀬俊, 髙尾正一郎, 山田博胤, 赤池雅史, 坂東左知子, 仁木敏之, 能勢隼人, 冨田紀子, 山口浩司, 竹谷善雄, 添木武, 西岡安彦, 原田雅史, 佐田政隆 :
肺，皮膚病変診断4年後に心病変が顕在化したサルコイドーシスの1例,
第22回日本心血管画像動態学会, 2012年1月. 仁木敏之, 若槻哲三, 山口浩司, 竹谷善雄, 岩瀬俊, 麻植塚浩康, 西尾進, 小笠原梢, 坂東美佳, 坂東左知子, 伊勢孝之, 冨田紀子, 山田博胤, 添木武, 佐田政隆 :
冠動脈プラークに対するスタチンへのEPA製剤add on 効果の検討-IB-IVUSおよびIB-頸動脈エコーの観点から-,
第22回日本心血管画像動態学会, 2012年1月. 前田香代子, 上田由佳, 伊勢孝之, 岩瀬俊, 西川幸治, 高島啓, 小笠原梢, 山崎宙, 坂東左知子, 仁木敏之, 發知淳子, 山口浩司, 冨田紀子, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 髙田信二郎, 安井夏生, 佐田政隆 :
大学病院での心臓リハビリテーション立ち上げの問題点,
第99回日本循環器学会四国地方会, 2011年12月. 坂東美佳, 林修司, 山田博胤, 冨田紀子, 發知淳子, 西尾進, 玉井利奈, 平田有紀奈, 弘田大智, 小笠原梢, 高島啓, 山崎宙, 坂東左知子, 伊勢孝之, 仁木敏之, 山口浩司, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 佐田政隆 :
平滑筋肉腫の心筋内転移の診断，経過観察に経胸壁心エコー法が有用であった一例,
第99回日本循環器学会四国地方会, 2011年12月. 高島啓, 山口浩司, 原知也, 山崎宙, 小笠原梢, 坂東左知子, 發知淳子, 冨田紀子, 竹内秀和, 仁木敏之, 伊勢孝之, 上田由佳, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 花岡潤, 島田光生, 佐田政隆 :
真性多血症患者に発症した心原生脾梗塞の1例,
第99回日本循環器学会四国地方会, 2011年12月. 田根なつ紀, 山口浩司, 竹谷善雄, 高島啓, 山崎宙, 小笠原梢, 坂東左知子, 仁木敏之, 伊勢孝之, 發知淳子, 岩瀬俊, 冨田紀子, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
重症下肢虚血病変に対して経皮的下肢動脈形成術が奏功し，予定されていた下肢切断手術を回避できた一症例,
第99回日本循環器学会四国地方会, 2011年12月. 高橋直希, 仁木敏之, 高島啓, 山崎宙, 小笠原梢, 坂東左知子, 伊勢孝之, 發知淳子, 山口浩司, 岩瀬俊, 竹谷善雄, 冨田紀子, 山田博胤, 添木武, 若槻哲三, 佐田政隆, 中瀧恵実子, 西村匡司, 上山祐二 :
低体温療法が著効し社会復帰をなし得たBrugada症候群の一例,
第99回日本循環器学会四国地方会, 2011年12月. 藤岡啓介, 山崎宙, 伊勢孝之, 楠瀬賢也, 木村白陽花, 高島啓, 小笠原梢, 坂東左知子, 發知淳子, 冨田紀子, 竹内秀和, 上田由佳, 仁木敏之, 山口浩司, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
ULPの発生から拡大，消失までを経時的に観察し得たacute aortic syndromeの一例,
第99回日本循環器学会四国地方会, 2011年12月. 坂東左知子, 山田博胤, 添木武, 木内誠, 北畑洋, 山口浩司, 竹谷善雄, 岩瀬俊, 若槻哲三, 佐田政隆 :
全身麻酔により顕在性Brugada型心電図の1例,
第105回日本内科学会四国地方会, 2011年11月. 山崎宙, 楠瀬賢也, 伊勢孝之, 竹谷善雄, 若槻哲三, 手塚敏史, 柿内聡司, 西岡安彦, 坂東良美, 佐田政隆 :
稀な画像所見を呈する肺アスペルギルス症により治療抵抗性心不全を認めた1症例,
第105回日本内科学会四国地方会, 2011年11月. 坂東左知子, 添木武, 伊勢孝之, 竹谷善雄, 岩瀬俊, 山田博胤, 若槻哲三, 木村建彦, 西内健, 佐田政隆 :
CRT-Dによって僧帽弁閉鎖不全症が劇的に改善した突発性拡張型心筋症の1例,
第105回日本内科学会四国地方会, 2011年11月. 岩瀬俊, 髙尾正一郎, 赤池雅史, 能勢隼人, 伊勢孝之, 小笠原梢, 山崎宙, 髙島啓, 坂東左知子, 仁木敏之, 楠瀬賢也, 發知淳子, 冨田紀子, 上田由佳, 山口浩司, 山田博胤, 添木武, 若槻哲三, 西岡安彦, 原田雅史, 佐田政隆 :
心臓MRIによるサルコイドーシス心病変検出の有用性,
第31回日本サルコイドーシス/肉芽腫性疾患学会総会, 2011年10月. 木谷光宏, 添木武, 仁木敏之, 楠瀬賢也, 山口浩司, 竹谷善雄, 岩瀬俊, 若槻哲三, 赤池雅史, 山本浩史, 折野俊介, 角谷昭佳, 坂東重信, 佐田政隆 :
高血圧患者におけるシルニジピンの酸化ストレスに対する作用,
第34回日本高血圧学会総会, 2011年10月. Takayuki Ise, Takashi Iwase, Kumiko Kagawa, Toshiyuki Niki, Kenya Kusunose, 冨田紀子, Yuka Ueda, Koji Yamaguchi, Yoshio Taketani, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Masahiro Abe, Masashi Akaike and Masataka Sata :
Successful Autologous Peripheral Blood Stem Cell Transplantation for Primary Cardiac Amyloidosis Patients with Heart Failure : three cases report.,
第15回日本心不全学会学術集会, Oct. 2011. 冨田紀子, 楠瀬賢也, 山田博胤, 西尾進, 林修司, 玉井利奈, 坂東左知子, 久岡白陽花, 上田由佳, 仁木敏之, 山口浩司, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 佐田政隆 :
心房細動における僧帽弁口血流速拡張早期波の心拍変動性の臨床的意義,
第59回日本心臓病学会学術集会, 2011年9月. 林修司, 山田博胤, 楠瀬賢也, 冨田紀子, 西尾進, 玉井利奈, 三木淳子, 坂東左知子, 仁木敏之, 山口浩司, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 佐田政隆 :
三尖弁輪運動速波形による肥大型心筋症と高血圧性心疾患の鑑別,
第59回日本心臓病学会学術集会, 2011年9月. 岩瀬俊, 髙尾正一郎, 赤池雅史, 能勢隼人, 久岡白陽花, 伊勢孝之, 仁木敏之, 楠瀬賢也, 山口浩司, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 西岡安彦, 原田雅史, 佐田政隆 :
サルコイドーシス心病変検出における心臓MRI検査の有用性,
第59回日本心臓病学会学術集会, 2011年9月. 坂東左知子, 添木武, 仁木敏之, 久岡白陽花, 竹内秀和, 冨田紀子, 楠瀬賢也, 上田由佳, 山口浩司, 竹谷善雄, 岩瀬俊, 山田博胤, 若槻哲三, 赤池雅史, 寒川賢治, 佐田政隆 :
グレリンによる自律神経およびConnexin43発現調節を介した抗不整脈作用の検討,
第59回日本心臓病学会学術集会, 2011年9月. 山田博胤, 楠瀬賢也, 西尾進, 冨田紀子, 玉井利奈, 清水拓, 林修司, 坂東左知子, 仁木敏之, 山口浩司, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 佐田政隆 :
膠原病における潜在性肺動脈性高血圧症の検出:運動負荷心エコー法の有用性,
第59回日本心臓病学会学術集会, 2011年9月. 西尾進, 山田博胤, 楠瀬賢也, 冨田紀子, 林修司, 玉井利奈, 三木淳子, 仁木敏之, 山口浩司, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 佐田政隆 :
冠動脈硬化症を最も反映する非侵襲的血管検査法についての検討,
第59回日本心臓病学会学術集会, 2011年9月. 玉井利奈, 山田博胤, 楠瀬賢也, 西尾進, 林修司, 冨田紀子, 坂東左知子, 仁木敏之, 山口浩司, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 佐田政隆 :
左心不全に合併した肺高血圧症における三尖弁輪運動速波形の特徴:HFPEFとHFREFの差異,
第59回日本心臓病学会学術集会, 2011年9月. 山口浩司, 若槻哲三, 添木武, 仁木敏之, 竹谷善雄, 麻植塚浩康, 坂東左知子, 上田由佳, 冨田紀子, 竹内秀和, 楠瀬賢也, 岩瀬俊, 山田博胤, 佐田政隆 :
冠動脈プラークに対するテルミサルタンの多面的効果の検討-Integrated backscatter IVUS観察と炎症性サイトカインによる観点から-,
第59回日本心臓病学会学術集会, 2011年9月. 添木武, 坂東左知子, 仁木敏之, 久岡白陽花, 竹内秀和, 楠瀬賢也, 上田由佳, 冨田紀子, 山口浩司, 竹谷善雄, 岩瀬俊, 山田博胤, 若槻哲三, 赤池雅史, 佐田政隆 :
心房細動における局所炎症反応に関する検討,
第59回日本心臓病学会学術集会, 2011年9月. 若槻哲三, 仁木敏之, 楠瀬賢也, 山口浩司, 竹谷善雄, 岩瀬俊, 麻植塚浩康, 西尾進, 坂東左知子, 冨田紀子, 竹内秀和, 山田博胤, 添木武, 佐田政隆 :
冠動脈プラークに対するスタチンへのEPA製剤add on効果の検討 -Integrated backscatter IVUSおよび局所Biomaker観察の観点から-,
第59回日本心臓病学会学術集会, 2011年9月. 仁木敏之, 若槻哲三, 山口浩司, 竹谷善雄, 楠瀬賢也, 小笠原梢, 高島啓, 山崎宙, 岩瀬俊, 佐田政隆 :
OCTにてneovascularizationを認めた冠動脈プラークのIB-IVUSによる組織性状の評価,
第18回日本心血管インターベンション治療学会中国・四国地方会, 2011年9月. 高木恵理, 高島啓, 山口浩司, 竹谷善雄, 坂東左知子, 冨田紀子, 竹内秀和, 仁木敏之, 楠瀬賢也, 上田由佳, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆, 森本篤志, 橋本一郎, 中西秀樹, 和田美智子, 石本武男, 田蒔正治 :
重症下肢虚血病変に対して経皮的下肢動脈血管形成術が奏功し，予定されていた下肢切手術を回避できた一症例,
第243回徳島医学会学術集会, 2011年7月. 原知也, 岩瀬俊, 高島啓, 山崎宙, 小笠原梢, 坂東左知子, 伊勢孝之, 仁木敏之, 楠瀬賢也, 上田由佳, 冨田紀子, 山口浩司, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
心サルコイドーシス診断の手引きにおける各種診断モダリティーの検討,
第243回徳島医学会学術集会, 2011年7月. 高島啓, 添木武, 山口浩司, 竹谷善雄, 坂東左知子, 林修司, 久岡白陽花, 冨田紀子, 竹内秀和, 仁木敏之, 楠瀬賢也, 上田由佳, 岩瀬俊, 山田博胤, 若槻哲三, 赤池雅史, 佐田政隆 :
埋め込み型デバイスにより胸郭内インピーダンスの増悪と改善が観察できた拡張相肥大型心筋症の一例,
第243回徳島医学会学術集会, 2011年7月. Koji Yamaguchi, Tetsuzo Wakatsuki, Kenya Kusunose, Toshiyuki Niki, Yoshio Taketani and Masataka Sata :
Different response of local persistent hypercoagulability after zotarolimus-eluting, paclitaxel-eluting, sirolimus-eluting and bare-metal stent implantaion.,
第20回日本心血管インターベンション治療学会 CVIT 2011, Jul. 2011. Toshiyuki Niki, Tetsuzo Wakatsuki, Koji Yamaguchi, Yoshio Taketani, Kenya Kusunose and Masataka Sata :
Impact of statin therapy on local coagulative response after sirolimus-eluting stent implantation in late chronic phase.,
第20回日本心血管インターベンション治療学会 CVIT 2011, Jul. 2011. 西川幸治, 上田由佳, 久岡白陽花, 前田香代子, 岩瀬俊, 坂東左知子, 林修司, 竹内秀和, 仁木敏之, 楠瀬賢也, 山口浩司, 冨田紀子, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 髙田信二郎, 安井夏生, 佐田政隆 :
当院心臓リハビリテーション参加者の運動能力について,
第17回日本心臓リハビリテーション学会学術集会, 2011年7月. 前田香代子, 上田由佳, 久岡白陽花, 岩瀬俊, 西川幸治, 坂東左知子, 林修司, 竹内秀和, 仁木敏之, 楠瀬賢也, 山口浩司, 冨田紀子, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 髙田信二郎, 安井夏生, 佐田政隆 :
大学病院での心臓リハビリテーション立ち上げに携わって,
第17回日本心臓リハビリテーション学会学術集会, 2011年7月. 久岡白陽花, 上田由佳, 岩瀬俊, 前田香代子, 西川幸治, 坂東左知子, 林修司, 竹内秀和, 仁木敏之, 楠瀬賢也, 山口浩司, 冨田紀子, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 髙田信二郎, 安井夏生, 佐田政隆 :
尿中アルブミン排泄量に及ぼす心臓リハビリテーションの効果,
第17回日本心臓リハビリテーション学会学術集会, 2011年7月. 竹内秀和, Tetsuzo Wakatsuki, 阪本紀子, Toshiyuki Niki, Kenya Kusunose, Koji Yamaguchi, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
BNP relates to FT3 negatively in cardiac patients with normal FT3, which might be mediated by HDAC3.,
第98回日本循環器学会中国・四国合同地方会, May 2011. Munkhbaatar Dagvasumberel, Junji Ueno, Shoichiro Takao, 西内健, 平田陽一郎, 坂東左知子, 久岡白陽花, 林修司, 冨田紀子, 竹内秀和, Yuka Ueda, Toshiyuki Niki, Kenya Kusunose, Koji Yamaguchi, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Tetsuya Kitagawa and Masataka Sata :
Increased epicardial adipose tissue and coronary atherosclerosis.,
第98回日本循環器学会中国・四国合同地方会, May 2011. 山中森晶, 山田博胤, 楠瀬賢也, 冨田紀子, 林修司, 仁木敏之, 山口浩司, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 佐田政隆, 西尾進, 玉井利奈, 三木淳子 :
ストロークケアユニット(SCU)に救急搬送された心原性脳塞栓症例の特徴,
第98回日本循環器学会中国・四国合同地方会, 2011年5月. 玉井利奈, 西尾進, 山田博胤, 楠瀬賢也, 冨田紀子, 林修司, 三木淳子, 坂東左知子, 仁木敏之, 山口浩司, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 佐田政隆 :
下肢静脈エコー検査におけるD-dimer値の意義,
第98回日本循環器学会中国・四国合同地方会, 2011年5月. 西尾進, 山田博胤, 玉井利奈, 平田陽一郎, 楠瀬賢也, 冨田紀子, 林修司, 三木淳子, 坂東左知子, 仁木敏之, 山口浩司, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 佐田政隆 :
頸動脈エコーによるプラークの超音波性状カラーイメージの試み,
第98回日本循環器学会中国・四国合同地方会, 2011年5月. 前田香代子, 上田由佳, 久岡白陽花, 岩瀬俊, 西川幸治, 坂東左知子, 林修司, 竹内秀和, 仁木敏之, 楠瀬賢也, 山口浩司, 冨田紀子, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 髙田信二郎, 安井夏生, 佐田政隆 :
通院型心臓リハビリテーションの継続における開始3カ月目の重要性,
第98回日本循環器学会中国・四国合同地方会, 2011年5月. 西川幸治, 上田由佳, 久岡白陽花, 前田香代子, 岩瀬俊, 坂東左知子, 林修司, 竹内秀和, 仁木敏之, 楠瀬賢也, 山口浩司, 冨田紀子, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 髙田信二郎, 安井夏生, 佐田政隆 :
心臓リハビリによる運動能力改善を阻害する因子の検討,
第98回日本循環器学会中国・四国合同地方会, 2011年5月. 太田理絵, 岩瀬俊, 久岡白陽花, 山田博胤, 西岡安彦, 髙尾正一郎, 坂東左知子, 能勢隼人, 楠瀬賢也, 仁木敏之, 冨田紀子, 上田由佳, 山口浩司, 竹谷善雄, 添木武, 若槻哲三, 赤池雅史, 曽根三郎, 佐田政隆 :
心室固有調律が心病変診断のきっかけとなったサルコイドーシスの1例,
第98回日本循環器学会中国・四国合同地方会, 2011年5月. 原知也, 楠瀬賢也, 山田博胤, 西尾進, 冨田紀子, 林修司, 玉井利奈, 坂東左知子, 久岡白陽花, 仁木敏之, 上田由佳, 山口浩司, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
心サルコイドーシスにおける左室形態異常の多様性,
第98回日本循環器学会中国・四国合同地方会, 2011年5月. 小笠原梢, 仁木敏之, 添木武, 坂東左知子, 久岡白陽花, 竹内秀和, 楠瀬賢也, 山口浩司, 竹谷善雄, 岩瀬俊, 冨田紀子, 山田博胤, 若槻哲三, 佐田政隆 :
様々な要因によりtorsade de pointesを来した一例,
第98回日本循環器学会中国・四国合同地方会, 2011年5月. 久岡白陽花, 上田由佳, 岩瀬俊, 前田香代子, 西川幸治, 坂東左知子, 林修司, 竹内秀和, 仁木敏之, 楠瀬賢也, 山口浩司, 冨田紀子, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 髙田信二郎, 安井夏生, 佐田政隆 :
尿中アルブミン排出量に及ぼす通院心臓リハビリテーションの効果,
第98回日本循環器学会中国・四国合同地方会, 2011年5月. 高島啓, 山口浩司, 添木武, 坂東左知子, 林修司, 久岡白陽花, 冨田紀子, 竹内秀和, 仁木敏之, 楠瀬賢也, 竹谷善雄, 岩瀬俊, 山田博胤, 若槻哲三, 佐田政隆 :
埋め込み型デバイスにより胸郭内インピーダンスの憎悪と改善が観察できた拡張肥大型心筋症の一例,
第98回日本循環器学会中国・四国合同地方会, 2011年5月. 冨田紀子, 山田博胤, 西尾進, 楠瀬賢也, 林修司, 玉井利奈, 遠藤桂輔, 平岡葉月, 佐藤光代, 坂東左知子, 久岡白陽花, 竹内秀和, 上田由佳, 仁木敏之, 山口浩司, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 佐田政隆 :
超高齢者における大動脈弁硬化の進行に関与する因子についての検討,
第98回日本循環器学会中国・四国合同地方会, 2011年5月. 林修司, 山田博胤, 楠瀬賢也, 冨田紀子, 西尾進, 玉井利奈, 三木淳子, 坂東左知子, 久岡白陽花, 仁木敏之, 山口浩司, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 佐田政隆 :
S字状中隔によるdynamic obstructionが胸痛の原因と考えられた高齢者の一例,
第98回日本循環器学会中国・四国合同地方会, 2011年5月. 坂東左知子, 添木武, 久岡白陽花, 冨田紀子, 竹内秀和, 仁木敏之, 楠瀬賢也, 山口浩司, 竹谷善雄, 岩瀬俊, 山田博胤, 若槻哲三, 赤池雅史, 佐田政隆 :
房室結節三重伝道路の存在が示唆された房室結節リエントリー性頻拍の1例,
第98回日本循環器学会中国・四国合同地方会, 2011年5月. 高島啓, 山口浩司, 坂東左知子, 林修司, 久岡白陽花, 冨田紀子, 竹内秀和, 仁木敏之, 楠瀬賢也, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 吉田守美子, 松本俊夫, 佐田政隆 :
甲状腺機能亢進症と腰痛が発症の誘因と考えられた難治性冠攣縮性狭心症の1例,
第98回日本循環器学会中国・四国合同地方会, 2011年5月. 外磯千智, 岩瀬俊, 楠瀬賢也, 山田博胤, 添木武, 若槻哲三, 佐田政隆, 赤池雅史, 髙尾正一郎, 原田雅史 :
心臓MRI検査で左室に広範なガドリニウム異常集積を認めたNoonan syndromeの1例,
第104回日本内科学会四国地方会, 2011年5月. 安積麻衣, 岩瀬俊, 仁木敏之, 若槻哲三, 佐田政隆, 赤池雅史, 髙尾正一郎, 原田雅史, 西岡安彦, 曽根三郎 :
眼，肺，筋病変に続いて経過中に新病変の顕在化を認めたサルコイドーシスの一例,
第104回日本内科学会四国地方会, 2011年5月. S. Bando, Takeshi Soeki, Toshiyuki Niki, Y. Hirata, N. Tomita, H. Takeuchi, Kenya Kusunose, Koji Yamaguchi, Yoshio Taketani, Takashi Iwase, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Plasma Brain Natriuretic Peptide (BNP) Level is Elevated in Patients with Cancer.,
第75回日本循環器学会総会・学術集会, Mar. 2011. 添木武, 仁木敏之, 山口浩司, S. Bando, 上田由佳, N. Tomita, 伊勢孝之, 楠瀬賢也, 竹谷善雄, 岩瀬俊, 山田博胤, 若槻哲三, 赤池雅史, 島袋充生, 佐田政隆 :
Inflammatory Biomarkers as Predictors of Vulnerable Coronary Plaques.,
第76回日本循環器学会学術集会，Symposium 3, 2011年3月. S. Nishio, Hirotsugu Yamada, Kenya Kusunose, N. Tomita, S. Hayashi, K. Endo, R. Tamai, J. Miki, S. Bando, Toshiyuki Niki, Koji Yamaguchi, Takashi Iwase, Yoshio Taketani, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Which Noninvasive Vascular Index is the Best Predictor of the Severity of Coronary Atherosclerosis?,
第75回日本循環器学会総会・学術集会, Mar. 2011. S. Hayashi, Hirotsugu Yamada, S. Nishio, N. Tomita, Kenya Kusunose, K. Endo, R. Tamai, S. Bando, S. Hisaoka, H. Takeuchi, Toshiyuki Niki, Koji Yamaguchi, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Tricuspid Annular Motion Velocity in Left Ventricular Hypertrophy: Comparison between Hypertensive Heart Disease and Hypertrophic Cardiomyopathy.,
第75回日本循環器学会総会・学術集会, Mar. 2011. Toshiyuki Niki, Takeshi Soeki, S. Bando, Kenya Kusunose, S. Hisaoka, S. Hayashi, Yuka Ueda, S. Tomita, H. Takeuchi, Takashi Iwase, Yoshio Taketani, Hirotsugu Yamada, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Role of Circulating High-Mobility Group Box-1 (HMGB1) in Patients with Coronary Artery Disease.,
第75回日本循環器学会総会・学術集会, Mar. 2011. Kenya Kusunose, Hirotsugu Yamada, N. Tomita, S. Nishio, S. Bando, S. Hisaoka, S. Hayashi, Toshiyuki Niki, Koji Yamaguchi, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Clinical Efficacy of Beat-to-beat Variability of Diastolic Filling in Atrial Fibrillation.,
第75回日本循環器学会総会・学術集会, Mar. 2011. Koji Yamaguchi, Tetsuzo Wakatsuki, Toshiyuki Niki, Koji Yamaguchi, S. Bando, S. Hisaoka, S. Hayashi, Yuka Ueda, N. Tomita, H. Takeuchi, Kenya Kusunose, Takashi Iwase, Yoshio Taketani, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Local Persistent Coagulative Response to Zotarolimus-eluting, Sirolimus-eluting and Bare-metal Stents Implanted in Patients with Stable Angina.,
第75回日本循環器学会総会・学術集会, Mar. 2011. Takashi Iwase, Shoichiro Takao, Masashi Akaike, S. Bando, S. Hisaoka, Toshiyuki Niki, Kenya Kusunose, N Tomita, Y. Hirata, Yuka Ueda, Koji Yamaguchi, Yoshio Taketani, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Ken-ichi Aihara, M. Harada and Masataka Sata :
Diagnostic Utility of Cardiac Magnetic Resonance for Prediction of Cardiac Events in Patients with Hypertrophic Cardiomyopathy.,
第75回日本循環器学会総会・学術集会, Mar. 2011. Tetsuzo Wakatsuki, Koji Yamaguchi, Yoshio Taketani, Toshiyuki Niki, Kenya Kusunose, N. Tomita, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Analysis of Tissue Characteristics of In-Stent Restenotic Lesion 5-Years after Coronary Stenting with Drug-Eluting Stent Using Integrated Backscatter Intravascular Ultrasound.,
第75回日本循環器学会総会・学術集会, Mar. 2011. 高柳友貴, 仁木敏之, 坂東左知子, 久岡白陽花, 林修司, 上田由佳, 冨田紀子, 竹内秀和, 楠瀬賢也, 山口浩司, 岩瀬俊, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆, 中山泰介, 北川哲也, 村野栄一 :
ペースメーカーリードの弁尖穿通による重症三尖弁逆流症の一例,
第242回徳島医学会学術集会，平成22年度冬期, 2011年2月. 坂東美佳, 仁木敏之, 楠瀬賢也, 山口浩司, 竹内秀和, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆, 能勢隼人, 大塚秀樹, 原田雅史 :
拡張型心筋症として診断・加療されていた心サルコイドーシスの一例,
第242回徳島医学会学術集会，平成22年度冬期, 2011年2月. 末広英也, 楠瀬賢也, 山田博胤, 西尾進, 冨田紀子, 坂東左知子, 久岡白陽花, 林修司, 仁木敏之, 山口浩司, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆, 能勢隼人, 大塚秀樹, 髙尾正一郎, 原田雅史 :
心サルコイドーシスにおける左室形態異常の多様性,
第242回徳島医学会学術集会，平成22年度冬期, 2011年2月. 太田理絵, 冨田紀子, 楠瀬賢也, 坂東左知子, 久岡白陽花, 林修司, 竹内秀和, 仁木敏之, 山口浩司, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆, 木村建彦, 西内健, 黒部裕嗣, 北川哲也 :
出産後の甲状腺機能亢進症が発見の契機となったLeft Main Coronary Trunk Compression Syndromeの一例,
第242回徳島医学会学術集会，平成22年度冬期, 2011年2月. 髙島啓, 楠瀬賢也, 山田博胤, 西尾進, 冨田紀子, 坂東左知子, 久岡白陽花, 林修司, 仁木敏之, 山口浩司, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆, 竹崎彰夫, 多田浩也, 曽根三郎 :
コントラスト心エコー法で診断できたHepatopulmonary Syndromeの1例,
第242回徳島医学会学術集会，平成22年度冬期, 2011年2月. 小笠原梢, 楠瀬賢也, 山田博胤, 西尾進, 冨田紀子, 仁木敏之, 山口浩司, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 竹崎彰夫, 多田浩也, 曽根三郎, 佐田政隆 :
コントラスト心エコー法で診断できたHepatopulmonary Syndromeの1例,
第97回日本循環器学会四国地方会, 2010年12月. 高柳友貴, 仁木敏之, 山田博胤, 楠瀬賢也, 山口浩司, 岩瀬俊, 冨田紀子, 竹谷善雄, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
ペースメーカーリードの弁尖穿通による重症三尖弁逆流症の1例,
第97回日本循環器学会四国地方会, 2010年12月. 竹内秀和, 平田陽一郎, 冨田紀子, Kenya Kusunose, Yoshio Taketani, Hirotsugu Yamada, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
HDL-C interacts to EPA positively,which might mean HDL-C regulates EPA via SREBP.,
第97回日本循環器学会四国地方会, Dec. 2010. 坂東美佳, 仁木敏之, 楠瀬賢也, 山口浩司, 竹内秀和, 竹谷義雄, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
心サルコイドーシスの1例,
第97回日本循環器学会四国地方会, 2010年12月. 末広英也, 楠瀬賢也, 山口浩司, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
心室中隔肥厚を認めた心サルコイドーシスの1例,
第103回日本内科学会四国地方会, 2010年11月. 山崎宙, 山口浩司, 楠瀬賢也, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
趾間部のマダニ咬傷後に足趾血行不良から壊死に陥った1例,
第103回日本内科学会四国地方会, 2010年11月. 山田博胤, 三代裕一郎, 楠瀬賢也, 仁木敏之, 林修司, 山口浩司, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
高齢者および壮年者における高圧利尿薬インダパミドの少量追加投与の有効性と安全性-連日投与と隔日投与の比較-,
第33回日本高血圧学会総会, 2010年10月. 山口浩司, 若槻哲三, 坂東左知子, 久岡白陽花, 仁木敏之, 楠瀬賢也, 冨田紀子, 竹内秀和, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 赤池雅史, 佐田政隆, 麻植塚浩康 :
冠動脈プラークに対する薬剤多面的効果の検討-Integrated backscatter IVUS観察による観点から-,
第58回日本心臓病学会学術集会, 2010年9月. 山口浩司, 若槻哲三, 仁木敏之, 楠瀬賢也, 竹谷善雄, 佐田政隆 :
スタチンによる冠動脈ステント植え込み後edge部性状の短絡的変化の検討―IB-IVUSにて観察した二例―,
第17回日本心血管インターベンション治療学会中国・四国地方会, 2010年9月. 門田宗之, 若槻哲三, 楠瀬賢也, 仁木敏之, 山口浩司, 竹谷善雄, 佐田政隆 :
繰り返す心不全と維持透析導入から離脱しえた腎動脈狭窄症の一例,
第17回日本心血管インターベンション治療学会中国・四国地方会, 2010年9月. 若槻哲三, 仁木敏之, 楠瀬賢也, 山口浩司, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 赤池雅史, 佐田政隆 :
薬剤溶出ステントによる冠動脈内皮機能障害の経年変化に関する検討,
第58回日本心臓病学会学術集会, 2010年9月. 冨田紀子, 山田博胤, 楠瀬賢也, 西尾進, 林修司, 遠藤桂輔, 河野裕美, 平岡葉月, 佐藤光代, 山口浩司, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
S字状中隔を呈する例の心エコー・ドプラ所見についての検討,
第58回日本心臓病学会学術集会, 2010年9月. 坂東左知子, 添木武, 仁木敏之, 久岡白陽花, 竹内秀和, 平田陽一郎, 冨田紀子, 楠瀬賢也, 山口浩司, 竹谷善雄, 岩瀬俊, 山田博胤, 若槻哲三, 赤池雅史, 佐田政隆 :
脳性ナトリウム利尿ペプチド(BNP)と癌との関係について,
第58回日本心臓病学会学術集会, 2010年9月. 添木武, 仁木敏之, 坂東左知子, 久岡白陽花, 竹内秀和, 楠瀬賢也, 冨田紀子, 平田陽一郎, 山口浩司, 竹谷善雄, 岩瀬俊, 山田博胤, 若槻哲三, 赤池雅史, 寒川賢治, 佐田政隆 :
グレリンの心臓自律神経への作用と心血管系における意義,
第58回日本心臓病学会学術集会, 2010年9月. 林修司, 山田博胤, 中田拓史, 楠瀬賢也, 西尾進, 冨田紀子, 玉井利奈, 遠藤桂輔, 河野裕美, 平岡葉月, 佐藤光代, 竹谷善雄, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
僧帽弁口血流速波形用いた左室拡張能評価の限界:E>Aパターンを呈する高齢者での検討,
第58回日本心臓病学会学術集会, 2010年9月. 遠藤桂輔, 山田博胤, 楠瀬賢也, 西尾進, 冨田紀子, 三木淳子, 林修司, 玉井利奈, 河野裕美, 平岡葉月, 佐藤光代, 添木武, 若槻哲三, 赤池雅史, 齋藤憲, 佐田政隆 :
EPA/AA比は冠動脈疾患の重症度に相関する:徳島大学病院循環器内科データベースを用いた検討,
第58回日本心臓病学会学術集会, 2010年9月. 仁木敏之, 若槻哲三, 山口浩司, 楠瀬賢也, 竹谷善雄, 岩瀬俊, 冨田紀子, 山田博胤, 添木武, 赤池雅史, 佐田政隆 :
薬剤溶出ステント植え込み慢性期における冠動脈局所凝固異常に対するスタチンの効果,
第58回日本心臓病学会学術集会, 2010年9月. 楠瀬賢也, 山田博胤, 西尾進, 冨田紀子, 玉井利奈, 遠藤桂輔, 三木淳子, 坂東左知子, 仁木敏之, 山口浩司, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
拡張型心筋症の左室内同期不全に対する前負荷増大の影響:3次元心エコー法を用いた検討,
第58回日本心臓病学会学術集会, 2010年9月. 玉井利奈, 山田博胤, 楠瀬賢也, 西尾進, 冨田紀子, 三木淳子, 林修司, 遠藤桂輔, 河野裕美, 平岡葉月, 佐藤光代, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
下肢陽圧負荷心エコー法が臨床的に有用であった肥大型心筋症の2例,
第58回日本心臓病学会学術集会, 2010年9月. 西尾進, 山田博胤, 楠瀬賢也, 冨田紀子, 林修司, 玉井利奈, 遠藤桂輔, 三木淳子, 竹崎彰夫, 多田浩也, 添木武, 若槻哲三, 赤池雅史, 曽根三郎, 佐田政隆 :
コントラスト心エコー法で診断できたHepatopulmonary Syndoromeの1例,
第58回日本心臓病学会学術集会, 2010年9月. 門田宗之, 楠瀬賢也, 竹谷善雄, 坂東左知子, 久岡白陽花, 仁木敏之, 冨田紀子, 竹内秀和, 山口浩司, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
繰り返す心不全と維持透析導入から離脱しえた腎動脈狭窄症の一例,
第241回徳島医学会学術集会(平成22年度夏期), 2010年8月. 阿部容子, 添木武, 仁木敏之, 楠瀬賢也, 平田陽一郎, 冨田紀子, 山口浩司, 竹谷善雄, 岩瀬俊, 山田博胤, 若槻哲三, 佐田政隆, 坂東正章, 清水渉 :
KCNH2遺伝子にダブル異変を認めた先天性QT延長症候群の兄弟例,
第241回徳島医学会学術集会(平成22年度夏期), 2010年8月. 山崎宙, 山口浩司, 坂東左知子, 久岡白陽花, 仁木敏之, 楠瀬賢也, 冨田紀子, 竹内秀和, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 佐田政隆, 福永豊, 中西秀樹 :
趾間部のマダニ咬傷後に足趾血行不良から壊死に陥った1例,
第241回徳島医学会学術集会(平成22年度夏期), 2010年8月. Koji Yamaguchi, Tetsuzo Wakatsuki, Kenya Kusunose, Toshiyuki Niki, Yoshio Taketani and Masataka Sata :
Two cases showing stabilization of coronary plaques in stent edge after statin therapy assessed by integrated backscatter intravascular ultrasound.,
第19回日本心血管インターベンション治療学会, Aug. 2010. 太田理絵, 仁木敏之, 岩瀬俊, 坂東左知子, 久岡白陽花, 楠瀬賢也, 上田由佳, 冨田紀子, 山口浩司, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 佐田政隆, 原田雅史, 髙尾正一郎 :
軽微な臨床経過にもかかわらず心臓MRI検査にて異常所見を認めた急性心筋炎の1例,
第241回徳島医学会学術集会(平成22年度夏期), 2010年7月. 小笠原梢, 仁木敏之, 楠瀬賢也, 山口浩司, 小柴邦彦, 冨田紀子, 竹谷善雄, 岩瀬俊, 山田博胤, 若槻哲三, 添木武, 赤池雅史, 佐田政隆, 北川哲也 :
IgA腎症ともやもや病を合併した若年発症の感染性心内膜炎の一例,
第96回日本循環器学会中国・四国合同地方会, 2010年6月. 岩河早保, 楠瀬賢也, 岩瀬俊, 仁木敏之, 山口浩司, 小柴邦彦, 冨田紀子, 竹谷善雄, 山田博胤, 若槻哲三, 赤池雅史, 佐田政隆, 橋詰俊二, 木村建彦, 西内健 :
出産後left main compression syndromeによる狭心症を発症した心内膜床欠損(不完全型)の1例,
第96回日本循環器学会中国・四国合同地方会, 2010年6月. 坂東美佳, 山口浩司, 岩瀬俊, 楠瀬賢也, 仁木敏之, 冨田紀子, 小柴邦彦, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
高度拡張不全による心不全症状の再燃を認めた心尖部肥大型心筋症の1例,
第96回日本循環器学会中国・四国合同地方会, 2010年6月. 阿部容子, 添木武, 仁木敏之, 楠瀬賢也, 平田陽一郎, 冨田紀子, 山口浩司, 小柴邦彦, 竹谷善雄, 岩瀬俊, 山田博胤, 若槻哲三, 赤池雅史, 坂東正章, 清水渉, 佐田政隆 :
KCNH2遺伝子にダブル変異を認めた先天性QT延長症候群の1例,
第96回日本循環器学会中国・四国合同地方会, 2010年6月. 楠瀬賢也, 竹谷善雄, 西尾進, 仁木敏之, 山口浩司, 小柴邦彦, 岩瀬俊, 冨田紀子, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
右腎癌摘出後に心不全を繰り返した腎動脈狭窄症の一例,
第96回日本循環器学会中国・四国合同地方会, 2010年6月. 仁木敏之, 添木武, 楠瀬賢也, 山口浩司, 小柴邦彦, 竹谷善雄, 岩瀬俊, 冨田紀子, 山田博胤, 若槻哲三, 赤池雅史, 佐田政隆 :
心電図異常が乏しいBrugada症候群の1例,
第96回日本循環器学会中国・四国合同地方会, 2010年6月. 鹿草宏, 仁木敏之, 楠瀬賢也, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
急性大動脈解離の1例,
日本内科学会第102回四国地方会, 2010年5月. 原知也, 仁木敏之, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆, 関啓 :
大動脈二尖弁における感染性心内膜炎に合併した大動脈弁輪周囲膿瘍の1例,
日本内科学会第102回四国地方会, 2010年5月. 竹谷善雄, 若槻哲三, 山田博胤, 山口浩司, 西尾進, 楠瀬賢也, 冨田紀子, 林修司, 仁木敏之, 小柴邦彦, 岩瀬俊, 添木武, 赤池雅史, 佐田政隆 :
スタチンによる冠動脈プラーク性状の短期変化についてのIB-IVUSを用いた検討,
第21回日本心エコー図学会学術集会, 2010年5月. 林修司, 山田博胤, 西尾進, 楠瀬賢也, 冨田紀子, 河野裕美, 平岡葉月, 佐藤光代, 三木淳子, 仁木敏之, 山口浩司, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
3次元経食道心エコー(3D-TEE)法にて経過が観察できた巨大左心耳血栓の1例,
第21回日本心エコー図学会学術集会, 2010年5月. 遠藤桂輔, 山田博胤, 西尾進, 冨田紀子, 楠瀬賢也, 林修司, 佐藤光代, 平岡葉月, 河野裕美, 三木淳子, 竹谷善雄, 添木武, 若槻哲三, 赤池雅史, 佐田政隆, 齋藤憲 :
リアルタイム3次元経食道エコー法により観察しえた孤立性僧帽弁クレフトの1例,
第21回日本心エコー図学会学術集会, 2010年5月. 楠瀬賢也, 山田博胤, 西尾進, 岩瀬俊, 冨田紀子, 林修司, 三木淳子, 遠藤桂輔, 河野裕美, 平岡葉月, 佐藤光代, 仁木敏之, 山口浩司, 小柴邦彦, 竹谷善雄, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
心房のみの心アミロイドーシスにおける心筋局所ストレインとMRIガドリニウム遅延造影所見の比較,
第21回日本心エコー図学会学術集会, 2010年5月. 西尾進, 山田博胤, 楠瀬賢也, 冨田紀子, 林修司, 三木淳子, 遠藤桂輔, 河野裕美, 平岡葉月, 佐藤光代, 仁木敏之, 山口浩司, 小柴邦彦, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
心房のみの心病変を認めた多発性筋炎の一例,
第21回日本心エコー図学会学術集会, 2010年5月. 山口浩司, 若槻哲三, 仁木敏之, 楠瀬賢也, 小柴邦彦, 八木秀介, 竹谷善雄, 岩瀬俊, 冨田紀子, 山田博胤, 添木武, 赤池雅史, 佐田政隆 :
シロリムス溶出性ステント留置後における局所凝固反応とステント長の関連性,
第57回日本心臓病学会学術集会, 2009年9月. 岩瀬俊, 髙尾正一郎, 赤池雅史, 足立克仁, 八木秀介, 仁木敏之, 楠瀬賢也, 山口浩司, 小柴邦彦, 山田博胤, 添木武, 若槻哲三, 原田雅史, 西谷弘, 佐田政隆 :
Duchenne型筋ジストロフィー女性キャリアにおける心病変早期検出の試み-心臓MRIによる検討-,
第57回日本心臓病学会学術集会, 2009年9月. 冨田紀子, 楠瀬賢也, 山田博胤, 西尾進, 遠藤桂輔, 仁木敏之, 山口浩司, 小柴邦彦, 八木秀介, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
大動脈弁硬化の進行に関連する因子,
第57回日本心臓病学会学術集会, 2009年9月. 小柴邦彦, 添木武, 仁木敏之, 楠瀬賢也, 平田陽一郎, 山口浩司, 冨田紀子, 八木秀介, 岩瀬俊, 山田博胤, 若槻哲三, 赤池雅史, 佐田政隆 :
Th1/Th2バランスの改善を介したPravastatinの実験的自己免疫性心筋炎抑制効果,
第57回日本心臓病学会学術集会, 2009年9月. 若槻哲三, 山口浩司, 仁木敏之, 楠瀬賢也, 小柴邦彦, 八木秀介, 岩瀬俊, 竹谷善雄, 冨田紀子, 山田博胤, 添木武, 赤池雅史, 佐田政隆 :
薬剤溶出ステント植え込み後慢性期の冠動脈局所炎症と凝固異常遷延の関連性,
第57回日本心臓病学会学術集会, 2009年9月. 楠瀬賢也, 山田博胤, 西尾進, 冨田紀子, 遠藤桂輔, 仁木敏之, 山口浩司, 小柴邦彦, 八木秀介, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
心房細動におけるE/e'の計測法:dual Doppler法を用いた検討,
第57回日本心臓病学会学術集会, 2009年9月. 西尾進, 山田博胤, 楠瀬賢也, 冨田紀子, 佐藤光代, 平岡葉月, 仁木敏之, 山口浩司, 小柴邦彦, 八木秀介, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
ASD，PSに合併した右室転移性腫瘤の1例,
第57回日本心臓病学会学術集会, 2009年9月. 添木武, 仁木敏之, 小柴邦彦, 楠瀬賢也, 平田陽一郎, 山口浩司, 八木秀介, 冨田紀子, 竹谷善雄, 岩瀬俊, 山田博胤, 若槻哲三, 赤池雅史, 佐田政隆 :
血漿pentraxin3 (PTX3)濃度は冠動脈不安定プラークの指標となり得るか?,
第57回日本心臓病学会学術集会, 2009年9月. 楠瀬賢也, 山田博胤, 西尾進, 冨田紀子, 遠藤桂輔, 仁木敏之, 山口浩司, 小柴邦彦, 八木秀介, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
僧帽弁口血流と僧帽弁輪運動の開始時間の差は左室拡張末期圧を反映する:下肢陽圧負荷を用いた検討,
第57回日本心臓病学会学術集会, 2009年9月. 近藤可菜, 八木秀介, 赤池雅史, 岩瀬俊, 楠瀬賢也, 仁木敏之, 山口浩司, 小柴邦彦, 竹谷善雄, 冨田紀子, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
重症心不全患者に対するAdaptive-servo ventilator療法の効果,
第239回徳島医学会学術集会, 2009年8月. 平田陽一郎, 仁木敏之, 山口浩司, 楠瀬賢也, 小柴邦彦, 八木秀介, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆, 黒部裕嗣, 神原保, 筑後文雄, 北川哲也, 堀貴樹 :
冠動脈周囲脂肪組織におけるマクロファージ浸潤の動脈硬化病変形成に与える影響,
第239回徳島医学会学術集会, 2009年8月. 仁木敏之, 若槻哲三, 山口浩司, 楠瀬賢也, 小柴邦彦, 八木秀介, 竹谷善雄, 冨田紀子, 岩瀬俊, 山田博胤, 添木武, 赤池雅史, 佐田政隆 :
たこつぼ型心筋障害の亜型と考えられた左室mid-portion ballooningの二例,
第94回日本循環器学会中国・四国合同地方会, 2009年6月. 楠瀬賢也, 山田博胤, 冨田紀子, 仁木敏之, 山口浩司, 小柴邦彦, 八木秀介, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
心エコーによる心病変の経過観察が可能であった続発性(AA)アミロイドーシスの一例,
第94回日本循環器学会中国・四国合同地方会, 2009年6月. 小柴邦彦, 仁木敏之, 楠瀬賢也, 平田陽一郎, 山口浩司, 冨田紀子, 竹谷善雄, 八木秀介, 岩瀬俊, 山田博胤, 若槻哲三, 添木武, 赤池雅史, 佐田政隆 :
多発性筋炎に伴う心障害の一例,
第94回日本循環器学会中国・四国合同地方会, 2009年6月. 八木秀介, 岩瀬俊, 赤池雅史, 山口浩司, 小柴邦彦, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
重症心不全患者における酸素療法とAdaptive-servo ventilator療法の効果の比較検討,
日本内科学会第100回四国地方会, 2009年5月. 佐藤光代, 楠瀬賢也, 山田博胤, 西尾進, 平岡葉月, 冨田紀子, 仁木敏之, 山口浩司, 小柴邦彦, 八木秀介, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
経食道心エコー検査により治療経過が観察できた高安動脈炎に伴う肺動脈狭窄症の一例,
第20回日本心エコー図学会学術集会, 2009年4月. 平岡葉月, 山田博胤, 西尾進, 佐藤光代, 高松直子, 楠瀬賢也, 冨田紀子, 仁木敏之, 山口浩司, 小柴邦彦, 八木秀介, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
心エコーによる心病変の経過観察が可能であった続発性(AA)アミロイドーシスの一例,
第20回日本心エコー図学会学術集会, 2009年4月. 西尾進, 山田博胤, 楠瀬賢也, 冨田紀子, 平岡葉月, 佐藤光代, 仁木敏之, 山口浩司, 小柴邦彦, 八木秀介, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
三尖弁輪運動速波形を用いた二次性肺高血圧の評価,
第20回日本心エコー図学会学術集会, 2009年4月. 楠瀬賢也, 山田博胤, 西尾進, 冨田紀子, 平岡葉月, 佐藤光代, 仁木敏之, 山口浩司, 小柴邦彦, 八木秀介, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
Post systolic shortening(PSS)による心筋虚血の検出,
第20回日本心エコー図学会学術集会, 2009年4月. 楠瀬賢也, 山田博胤, 西尾進, 冨田紀子, 平岡葉月, 佐藤光代, 仁木敏之, 山口浩司, 小柴邦彦, 八木秀介, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
僧帽弁口血流と僧帽弁輪運動の不整合は左室拡張能の評価に有用か:dual Doppler systemを用いた検討,
第20回日本心エコー図学会学術集会, 2009年4月. 楠瀬賢也, 山田博胤, 西尾進, 仁木敏之, 冨田紀子, 山口浩司, 小柴邦彦, 八木秀介, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 河野智彦, 佐田政隆 :
右心不全を契機に診断された肺動脈狭窄症の一例,
第93回日本循環器学会四国地方会, 2008年12月. 八木秀介, 岩瀬俊, 楠瀬賢也, 仁木敏之, 山口浩司, 小柴邦彦, 冨田紀子, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
強皮症に伴う難治性末梢循環不全に対するエンドセリン受容体拮抗薬の有用性,
第93回日本循環器学会四国地方会, 2008年12月. 小柴邦彦, 添木武, 仁木敏之, 楠瀬賢也, 山口浩司, 冨田紀子, 八木秀介, 岩瀬俊, 山田博胤, 若槻哲三, 赤池雅史, 佐田政隆 :
両側肺血栓症と多発性体循環系塞栓症を合併した1例,
第93回日本循環器学会四国地方会, 2008年12月. 山口浩司, 若槻哲三, 仁木敏之, 楠瀬賢也, 小柴邦彦, 冨田紀子, 八木秀介, 岩瀬俊, 山田博胤, 添木武, 赤池雅史, 佐田政隆 :
冠動脈ステント3種(CYPHER, TAXUS, DRIVER)の慢性期病理組織所見の比較と局所凝固反応の関連性,
第93回日本循環器学会四国地方会, 2008年12月. 西尾進, 山田博胤, 楠瀬賢也, 仁木敏之, 山口浩司, 八木秀介, 小柴邦彦, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 永峰康孝, 佐田政隆 :
Automated Function Imaging法による左室局所壁運動異常評価:心エコー初心者による肉眼的評価との比較,
第56回日本心臓病学会学術集会, 2008年9月. 楠瀬賢也, 山田博胤, 西尾進, 仁木敏之, 山口浩司, 八木秀介, 小柴邦彦, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
高血圧性心疾患における左房ポンプ機能の評価:Left Atrial Ejection Forceを用いた検討,
第56回日本心臓病学会学術集会, 2008年9月. 若槻哲三, 山口浩司, 仁木敏之, 楠瀬賢也, 小柴邦彦, 八木秀介, 岩瀬俊, 山田博胤, 添木武, 赤池雅史, 佐田政隆 :
薬剤溶出ステント植え込み後の冠動脈内皮機能障害と局所炎症遷延の関連性,
第56回日本心臓病学会学術集会, 2008年9月. 楠瀬賢也, 山田博胤, 西尾進, 仁木敏之, 山口浩司, 八木秀介, 小柴邦彦, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
心房細動におけるTEI indexの有用性:Dual Doppler法を用いた検討,
第56回日本心臓病学会学術集会, 2008年9月. 仁木敏之, 添木武, 小柴邦彦, 楠瀬賢也, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 若槻哲三, 赤池雅史, 福田大和, 篠原尚典, 福田信夫, 田村禎通, 佐田政隆 :
虚血性心疾患におけるHMGBI (high mobility group box 1) の診断的意義,
第56回日本心臓病学会学術集会, 2008年9月. T Niki, Takeshi Soeki, Kenya Kusunose, K Yamaguchi, K Koshiba, Tomohito Kawano, Hirotsugu Yamada, Tetsuzo Wakatsuki and Kenji Kangawa :
Elevated Concentration of Interferon-Inducible Protein of 10kd (IP-10) is Associated with Coronary Atherosclerosis.,
72th Annual scientific meeting of the Japanese circulation society, Mar. 2008. K Yamaguchi, Tetsuzo Wakatsuki, Kenya Kusunose, T Niki, K Koshiba, Tomohito Kawano, Hirotsugu Yamada and Takeshi Soeki :
Predictors of Local Hypercoagulability after Sirolimus-Eluting Stent Implantation: Implication for Correlates of Late Stent Thrombosis.,
72th Annual scientific meeting of the Japanese circulation society, Mar. 2008. Takeshi Soeki, T Niki, K Koshiba, Kenya Kusunose, K Yamaguchi, Tomohito Kawano, Hirotsugu Yamada and Tetsuzo Wakatsuki :
Elevated Concentration of Pentraxin 3 is Associated with Coronary Plaque Vulnerability.,
72th Annual scientific meeting of the Japanese circulation society, Mar. 2008. Takeshi Soeki, K Koshiba, T Niki, Kenya Kusunose, K Yamaguchi, Tomohito Kawano, Hirotsugu Yamada, Tetsuzo Wakatsuki and Kenji Kangawa :
Ghrelin Attenuates Myocardial Ischemia/Reperfusion Injury via the Extracellular Signal-Regulated Kinase 1/2 and Phosphatidylinositol.,
72th Annual scientific meeting of the Japanese circulation society, Mar. 2008. Tetsuzo Wakatsuki, K Yamaguchi, T Niki, Kenya Kusunose, K Koshiba, Takeshi Soeki and Hirotsugu Yamada :
Long-Term Local Inflammatory Response after Coronary Artery Stenting with Drug-Eluting Stent.,
72th Annual scientific meeting of the Japanese circulation society, Mar. 2008. Kenya Kusunose, Hirotsugu Yamada, A Iga, T Niki, K Yamaguchi, K Koshiba, Takeshi Soeki and Tetsuzo Wakatsuki :
Left Atrial Volume dose not reflect Brain Natriuretic Peptide Levels in Patients with Atrial Fibrillation.,
72th Annual scientific meeting of the Japanese circulation society, Mar. 2008. Kenya Kusunose, Hirotsugu Yamada, A Iga, T Niki, K Yamaguchi, K Koshiba, Takeshi Soeki and Tetsuzo Wakatsuki :
Importance of Left Atrial Function for the Pseudonormalization of Transmitral Flow Velocity Pattern in Patients with Hypertrophic Cardiomyopathy.,
72th Annual scientific meeting of the Japanese circulation society, Mar. 2008. Hirotsugu Yamada, Kenya Kusunose, A Iga, T Niki, K Yamaguchi, K Koshiba, Takeshi Soeki and Tetsuzo Wakatsuki :
E/e' as a Predictor of the Cardiac Response to Increment of Preload in Patients with Atrial Fibrillation.,
72th Annual scientific meeting of the Japanese circulation society, Mar. 2008. 楠瀬賢也, 山田博胤, 仁木敏之, 山口浩司, 小柴邦彦, 添木武, 若槻哲三, 八木秀介, 岩瀬俊, 赤池雅史, 阿部美保, 北川哲也 :
両心房腫瘤の一例,
第102回UCG談話会, 2008年2月. 仁木敏之, 添木武, 楠瀬賢也, 山口浩司, 小柴邦彦, 河野智仁, 山田博胤, 若槻哲三 :
特定の薬物療法が功を奏した心房頻拍の1例,
第97回日本内科学会四国地方会, 2007年12月. 楠瀬賢也, 添木武, 仁木敏之, 山口浩司, 小柴邦彦, 山田博胤, 若槻哲三, 八木秀介, 岩瀬俊, 赤池雅史 :
心エコーで心室中隔瘤の診断に苦慮した心サルコイドーシスの一例,
第91回日本循環器学会四国地方会学術集会, 2007年11月. 楠瀬賢也, 山田博胤, 佐藤光代, 平岡葉月, 河野裕美, 仁木敏之, 山口浩司, 小柴邦彦, 添木武, 若槻哲三 :
肥大型心筋症の僧帽弁口血流速波形における左房機能の影響:左房容積曲線を用いた検討,
第17回日本超音波医学会四国地方会学術集会, 2007年10月. 佐藤光代, 山田博胤, 楠瀬賢也, 岩瀬俊, 平岡葉月, 河野裕美, 仁木敏之, 山口浩司, 小柴邦彦, 河野智仁, 添木武, 若槻哲三 :
不可解な心電図異常を呈する親子,
第17回日本超音波医学会四国地方会学術集会, 2007年10月. 楠瀬賢也, 山田博胤, 仁木敏之, 山口浩司, 小柴邦彦, 河野智仁, 添木武, 若槻哲三, 八木秀介, 岩瀬俊, 赤池雅史, 谷口哲三, 髙尾正一郎 :
不可解な心電図異常を呈し，肥大型心筋症を疑う1例,
第12回中国四国心筋症研究会, 2007年9月. 仁木敏之, 添木武, 楠瀬賢也, 山口浩司, 小柴邦彦, 河野智仁, 山田博胤, 若槻哲三 :
冠動脈硬化病変と血中ケモカイン濃度との関連性,
第55回日本心臓病学会学術集会, 2007年9月. 添木武, 仁木敏之, 楠瀬賢也, 山口浩司, 小柴邦彦, 河野智仁, 山田博胤, 若槻哲三 :
冠動脈硬化症と血漿pentraxin3(PTX3)値の関係,
第55回日本心臓病学会学術集会, 2007年9月. 山田博胤, 山崎聖広, 楠瀬賢也, 仁木敏之, 山口浩司, 小柴邦彦, 河野智仁, 添木武, 若槻哲三 :
断層心エコー法による左房容積の計測およびそれにおける僧帽弁逆流の影響,
第55回日本心臓病学会学術集会, 2007年9月. 小柴邦彦, 添木武, 仁木敏之, 楠瀬賢也, 山口浩司, 河野智仁, 山田博胤, 若槻哲三 :
C型ナトリウム利尿ペプチドは自己免疫性心筋炎の進展を抑制する,
第55回日本心臓病学会学術集会, 2007年9月. 山田博胤, 楠瀬賢也, 仁木敏之, 山口浩司, 小柴邦彦, 河野智仁, 添木武, 若槻哲三, 三代裕一郎 :
アンギオテンシンⅡ受容体拮抗薬(ARB)投与症例におけるインダパミド少量追加投与の効果,
第55回日本心臓病学会学術集会, 2007年9月. 楠瀬賢也, 山田博胤, 濱本秀一, 仁木敏之, 山口浩司, 小柴邦彦, 河野智仁, 添木武, 若槻哲三 :
心房細動における拡張早期僧帽弁輪運動速度の心室中隔側および左室側壁側における差の検討-Dual Doppler法を用いて-,
第55回日本心臓病学会学術集会, 2007年9月. Kenya Kusunose, Hirotsugu Yamada, T Nakajima, T Niki, K Yamaguchi, K Koshiba, Tomohito Kawano, Takeshi Soeki, Tetsuzo Wakatsuki and Susumu Ito :
Simultaneously Recorded E/Ew Refletcts Plasma BNP Level in Patients with Atrial Fibrillation.,
71th Annual scientific meeting of the Japanese circulation society, Mar. 2007. 楠瀬賢也, 山田博胤, 中島智博, 仁木敏之, 福田大和, 山口浩司, 小柴邦彦, 河野智仁, 添木武, 若槻哲三, 伊東進 :
体位変換により出現する低酸素血症の診断にコントラスト心エコー法が有用であった一例,
第89回日本循環器学会四国地方会, 2006年12月. 中島智博, 添木武, 若槻哲三, 仁木敏之, 楠瀬賢也, 山口浩司, 小柴邦彦, 河野智仁, 山田博胤, 伊東進 :
PP間隔が不規則な上室性頻拍に対しCARTOを用いたAblationが有用であった1例,
第89回日本循環器学会四国地方会, 2006年12月. 楠瀬賢也, 山田博胤, 中島智博, 仁木敏之, 福田大和, 山口浩司, 小柴邦彦, 河野智仁, 添木武, 若槻哲三, 伊東進 :
体位変換により出現する低酸素血症の診断にコントラスト心エコー法が有用であった一例,
第16回日本超音波医学会四国地方会, 2006年10月. 若槻哲三, 福田大和, 山口浩司, 小柴邦彦, 河野智仁, 添木武, 山田博胤 :
薬剤溶出ステントは長期に冠動脈局所の内皮機能を障害する,
第54回日本心臓病学会学術集会, 2006年9月. 山田博胤, 福田大和, 山口浩司, 小柴邦彦, 河野智仁, 添木武, 若槻哲三 :
心房細動に対するCoupled Pacing におけるペーシング遅延時間の差による影響,
第54回日本心臓病学会学術集会, 2006年9月. 中島智博, 山田博胤, 楠瀬賢也, 仁木敏之, 山口浩司, 小柴邦彦, 河野智仁, 添木武, 若槻哲三, 伊東進 :
ヒト心房性利尿ペプチドの間歇投与が有効な拡張層家族性肥大型心筋症の1例,
第11回中四国心筋症・心不全研究会, 2006年9月. 楠瀬賢也, 山田博胤, 中島智博, 仁木敏之, 福田大和, 山口浩司, 小柴邦彦, 河野智仁, 添木武, 若槻哲三, 伊東進 :
体位変換により出現する低酸素血症の診断にコントラスト心エコー法が有用であった一例,
徳島心エコー図研究会, 2006年8月. 楠瀬賢也, 山田博胤, 中島智博, 仁木敏之, 福田大和, 山口浩司, 小柴邦彦, 河野智仁, 添木武, 若槻哲三, 伊東進 :
体位変換により出現する低酸素血症の診断にコントラスト心エコー法が有用であった一例,
第4回先進血管エコー研究会, 2006年8月. 楠瀬賢也, 山田博胤, 中島智博, 仁木敏之, 福田大和, 山口浩司, 小柴邦彦, 河野智仁, 添木武, 若槻哲三, 伊東進 :
体位変換性の低酸素血症の診断にコントラスト心エコー法が有用であった一例,
第98回UCG談話会, 2006年7月. Tetsuzo Wakatsuki, Koji Yamaguchi, Kunihiko Koshiba, Tomohito Kawano, Takeshi Soeki, Yamato Fukuda, Hirotsugu Yamada and Susumu Ito :
Long-term endothelial dysfunction after coronary artery stenting with drug-eluting stent,
第70回日本循環器学会総会・学術集会, Mar. 2006. Takeshi Soeki, Yamato Fukuda, Kunihiko Koshiba, Koji Yamaguchi, Tomohito Kawano, Tomohito Kawano, Hirotsugu Yamada, Tetsuzo Wakatsuki, Masahiro Nomura, Kenji Kangawa and Susumu Ito :
Ghrelin Protects Myocardium Against Ischemia/Reperfusion Injury via Inhibiting Myocardial Apoptosis,
第70回日本循環器学会総会, Mar. 2006. Hirotsugu Yamada, H Motonari, Y Fukuda, K Yamaguchi, K Koshiba, Tomohito Kawano, Takeshi Soeki, Tetsuzo Wakatsuki and Susumu Ito :
Effect of Aging on Left Atrial Function Evaluated by 2D Tissue Tracking.,
70th Annual scientific meeting of the Japanese circulation society, Mar. 2006. Hirotsugu Yamada, Y Fukuda, K Yamaguchi, K Koshiba, Tomohito Kawano, Takeshi Soeki, Tetsuzo Wakatsuki, Susumu Ito and Y Mishiro :
The Effects of the Addition of Minimal Dose of Indapamide in Patients Receiving Angiotensin-II Receptor Blocker.,
70th Annual scientific meeting of the Japanese circulation society, Mar. 2006. 山口浩司, 若槻哲三, 福田大和, 小柴邦彦, 河野智仁, 山田博胤, 添木武, 岩瀬俊, 藤村光則, 赤池雅史, 東博之 :
たこつぼ型心筋障害の亜型と考えられた左室mid-portion ballooningの一例,
第87回日本循環器学会中国・四国合同地方会, 2005年11月. 若槻哲三, 山口浩司, 小柴邦彦, 河野智仁, 添木武, 福田大和, 山田博胤, 田畑智継, 森一博 :
川崎病既往成人例および一般高齢者における冠動脈病変の特徴の差異 ―冠動脈内温度変化の観点から―,
第53回日本心臓病学会学術集会, 2005年9月. 河野智仁, 福田大和, 渡部智紀, 山口浩司, 小柴邦彦, 山田博胤, 添木武, 若槻哲三, 田畑智継, 野村昌弘 :
本態性高血圧症におけるアゼルニジピンの自律神経活動に及ぼす影響についての検討,
第53回日本心臓病学会, 2005年9月. 河野智仁, 福田大和, 渡部智紀, 山口浩司, 小柴邦彦, 山田博胤, 添木武, 若槻哲三, 田畑智継, 野村昌弘 :
アトルバスタチンの抗酸化作用と冠動脈プラーク安定化の評価:16列マルチスライスCTを用いた検討,
第53回日本心臓病学会, 2005年9月. 福田大和, 若槻哲三, 山口浩司, 小柴邦彦, 河野智仁, 添木武 :
不安定プラークに対するDES hot spot stentingを考えさせられた一例,
第12回日本心血管インターベンション学会・第2回日本心血管カテーテル治療学会中国・四国合同地方会, 2005年9月. 小柴邦彦, 河野智仁, 福田大和, 渡部智紀, 山口浩司, 山田博胤, 添木武, 若槻哲三, 田畑智継, 野村昌弘 :
ドキソルビシン心筋症ラットにおける顆粒球コロニー刺激因子投与によるアポトーシス抑制効果の検討,
第53回日本心臓病学会学術集会, 2005年9月. 小柴邦彦, 河野智仁, 福田大和, 渡部智紀, 山口浩司, 山田博胤, 添木武, 若槻哲三, 田畑智継, 野村昌弘 :
本態性高血圧症におけるアゼルニジピンの自律神経活動に及ぼす影響についての検討,
第53回日本心臓病学会学術集会, 2005年9月. 小柴邦彦, 河野智仁, 福田大和, 渡部智紀, 山口浩司, 山田博胤, 添木武, 若槻哲三, 田畑智継, 野村昌弘 :
アゼルニジピンによる抗動脈硬化作用および心肥大抑制作用の検討,
第53回日本心臓病学会学術集会, 2005年9月. 田畑智継, 山田博胤, 福田大和, 山口浩司, 小柴邦彦, 河野智仁, 添木武, 若槻哲三, 長野智章 :
2D tissue tracking 法を用いた左房容積変化の評価,
第53回日本心臓病学会学術集会, 2005年9月. 田畑智継, 山田博胤, 田中英治, 福田大和, 山口浩司, 小柴邦彦, 河野智仁, 添木武, 若槻哲三 :
ストレインイメージング法を用いた僧帽弁口血流速波形の偽正常化の再評価:左房機能との関係において,
第53回日本心臓病学会学術集会, 2005年9月. 山田博胤, 田畑智継, 本成永, 田中英治, 福田大和, 山口浩司, 小柴邦彦, 河野智仁, 添木武, 若槻哲三 :
2D組織トラッキング法を用いた左房リザーバー機能の評価,
第53回日本心臓病学会学術集会, 2005年9月. 福田大和, 若槻哲三, 山口浩司, 小柴邦彦, 河野智仁, 添木武 :
DES時代におけるhot spot stentingを考えさせられた一例,
第32回徳島心血管造影研究会, 2005年7月. 山口浩司, 若槻哲三, 木村恵理子, 小柴邦彦, 河野智仁, 山田博胤, 田畑智継, 西角彰良, 野村昌弘, 楠完治, 伊東進, 来島敦史, 北川哲也 :
左心室造影にて偶然発見し得た左室microaneurysmの一例,
第86回日本循環器学会四国地方会, 2005年6月. 原田顕治, 山田博胤, 田畑智継, 伊賀彰子, 小柴邦彦, 山口浩司, 河野智仁, 若槻哲三, 西角彰良, 野村昌弘, 伊東進 :
多彩な心室壁の肥大形態を示した肥大型心筋症(HCM)の一家系,
日本超音波医学会四国地方会, 2005年6月. T Watanabe, Masahiro Nomura, E Kimura, K Yamaguchi, K Koshiba, Tomohito Kawano, Hirotsugu Yamada, Tetsuzo Wakatsuki, Tomotsugu Tabata, Akiyoshi Nishikado, Yutaka Nakaya and Susumu Ito :
Antioxydative Effect and Atrial Electrophysiological Improvement by Candesartan in Hypertensive Patients.,
69th Annual scientific meeting of the Japanese circulation society, Mar. 2005. K Yamaguchi, Masahiro Nomura, E Kimura, T Watanabe, K Koshiba, Tomohito Kawano, Hirotsugu Yamada, Tetsuzo Wakatsuki, Tomotsugu Tabata, Akiyoshi Nishikado, Susumu Ito and Yutaka Nakaya :
Dose Obstructive Sleep Apnea Syndrome (OSAS) Cause the Myocardial Injury? Examination by 99mTc-MIBI Scintigraphy.,
69th Annual scientific meeting of the Japanese circulation sciety, Mar. 2005. K Yamaguchi, Masahiro Nomura, E Kimura, T Watanabe, K Koshiba, Tomohito Kawano, Hirotsugu Yamada, Tetsuzo Wakatsuki, Tomotsugu Tabata, Akiyoshi Nishikado, Susumu Ito and Yutaka Nakaya :
Effect of Carvedilol on Autonomic Nerves Function and Oxidative Stress in the Essential Hypertensive Patients with Obstructive Sleep Apnea Syndrome.,
69th Annual scientific meeting of the Japanese circulation society, Mar. 2005. K Yamaguchi, Masahiro Nomura, E Kimura, T Watanabe, K Koshiba, Tomohito Kawano, Hirotsugu Yamada, Tetsuzo Wakatsuki, Tomotsugu Tabata, Akiyoshi Nishikado, Susumu Ito and Yutaka Nakaya :
Atherosclerosis Suppression Effect of Estrogen: Is the Chronic Liver Disease Atherogenic?,
69th Annual scientific meeting of the Japanese circulation society, Mar. 2005. Masahiro Nomura, E Kimura, T Watanabe, K Yamaguchi, K Koshiba, Tomohito Kawano, Hirotsugu Yamada, Tetsuzo Wakatsuki, Tomotsugu Tabata, Akiyoshi Nishikado, Susumu Ito and Yutaka Nakaya :
Current Density Map at Ventricular Repolarization Phase in Myocardial Infarction.,
69th Annual scientific meeting of the Japanese circulation society, Mar. 2005. Hirotsugu Yamada, Tomotsugu Tabata, H Baba, K Yamaguchi, K Koshiba, Tomohito Kawano, Tetsuzo Wakatsuki, Masahiro Nomura and Susumu Ito :
Quantitative Assessment of Left Ventricular Torsion by Two-dimensional Echocardiographic Automated Tissue Tracking Techinique.,
69th Annual scientific meeting of the Japanese circulation society, Mar. 2005. 山田博胤, 田畑智継, 河野智仁, 山口浩司, 小柴邦彦, 若槻哲三, 西角彰良, 野村昌弘, 伊東進 :
拡大不全心における左房リザーバー機能の定量的評価:組織ストレインイメージングを用いた検討,
第85回日本循環器学会中国・四国合同地方会, 2004年11月. 小柴邦彦, 野村昌弘, 河野智仁, 山口浩司, 木村恵理子, 山田博胤, 若槻哲三, 田畑智継, 西角彰良, 伊東進 :
G-CSF の心筋への効果:アドリアマイシン心筋症ラットにおける検討,
第91回日本内科学会四国地方会, 2004年11月. 田中英治, 田畑智継, 原田顕治, 山田博胤, 若槻哲三, 河野智仁, 山口浩司, 小柴邦彦, 野村昌弘 :
左室収縮は全周性に均一か?経胸壁および経食道心エコー法によって得られる心筋ストレインの比較,
第52回日本心臓病学会学術集会, 2004年9月.

(要約): 左室前壁側のストレインは後壁側よりも低値を示した．左室前壁側の収縮は後壁側よりも小で，左室短軸方向の収縮が全周性に均一でないことが判明した．

田畑智継, 田中英治, 原田顕治, 山田博胤, 若槻哲三, 河野智仁, 山口浩司, 小柴邦彦, 野村昌弘 :
ストレインイメージング法を用いた左房機能の評価:下半身陽圧負荷を用いた検討,
第52回日本心臓病学会学術集会, 2004年9月.

(要約): 下半身陽圧負荷を用いて，ストレインイメージング法により左房心筋のリザーバーおよびポンプ機能を評価した．

田中英治, 田畑智継, 原田顕治, 山田博胤, 若槻哲三, 河野智仁, 山口浩司, 小柴邦彦, 野村昌弘 :
ストレインイメージング法を用いた左室収縮能の評価:健常例におけるradial, meridionalおよびcircumferential systolic strainの検討,
第52回日本心臓病学会学術集会, 2004年9月.

(要約): 左室収縮は短軸方向のthickeningと長軸および円周方向のshorteningの複合によって行われ，左室後壁の短軸方向のthiceningが最も大であった．

田中英治, 田畑智継, 原田顕治, 山田博胤, 若槻哲三, 河野智仁, 小柴邦彦, 山口浩司, 西角彰良, 野村昌弘, 伊東進 :
ストレインイメージング法を用いた左室収縮動態の詳細な評価:健常例におけるradial, meridional, circumferential systolic strainの検討,
第2回先進心血管エコー研究会, 2004年8月. 山口浩司, 野村昌弘, 小柴邦彦, 河野智仁, 木村恵理子, 山田博胤, 若槻哲三, 田畑智継, 西角彰良, 伊東進 :
酸素摂取量と血中ホモシステインとの関連性:トータル・ヘルス・プロモーション・プラン検診による検討,
第54回循環器負荷研究会, 2004年8月. H Tanaka, Tomotsugu Tabata, K Harada, E Kimura, Hirotsugu Yamada, Tetsuzo Wakatsuki, Masahiro Nomura and Susumu Ito :
Dose-by-dose assessment of left ventricular myocardial ischemia during high dose dobutamine stress echocardiography.,
68th Annual scientific meeting of the Japanese circulation society, Mar. 2004. Tomotsugu Tabata, H Tanaka, K Harada, E Kimura, Hirotsugu Yamada, Tetsuzo Wakatsuki, Masahiro Nomura and Susumu Ito :
Long term assessment in the morphologic change in hypertrophic cardiomyopathy since 1979 in our laboratory.,
68th Annual scientific meeting of the Japanese circulation society, Mar. 2004. Tomotsugu Tabata, H Tanaka, K Harada, E Kimura, Hirotsugu Yamada, Tetsuzo Wakatsuki, Masahiro Nomura and Susumu Ito :
Impact of Losartan on Geometric Change for an Improved LV Performance in Hypertensive Heart.,
68th Annual scientific meeting of the Japanese circulation society, Mar. 2004. H Tanaka, Tomotsugu Tabata, E Kimura, K Harada, Tetsuzo Wakatsuki, T Yamamoto, A Saito, K Uehara, N Kageyama, Akiyoshi Nishikado, Masahiro Nomura, Hirotsugu Yamada, Susumu Ito and T Oki :
Impact of Losartan on left ventricular myocardial function in hypertensive hypertrophy: assessment of myocardial velocity profile and plasma vasoactive peptide.,
67th Annual Scientific Meeting of the Japanese Circulation Society, Mar. 2003. H Tanaka, Tomotsugu Tabata, E Kimura, K Harada, Tetsuzo Wakatsuki, T Yamamoto, A Saito, K Uehara, N Kageyama, Akiyoshi Nishikado, Masahiro Nomura, Hirotsugu Yamada, Susumu Ito and T Oki :
Quantitative assessment of left ventricular myocardial viability during low dose dobutamine stress echocardiography in combination with color tissue Doppler imaging.,
67th Annual Scientific Meeting of the Japanese Circulation Society, Mar. 2003. K Harada, Tomotsugu Tabata, H Tanaka, E Kimura, Tetsuzo Wakatsuki, T Yamamoto, K Uehara, A Saito, N Kageyama, Akiyoshi Nishikado, Masahiro Nomura, Hirotsugu Yamada, Susumu Ito and T Oki :
Better choice of color tissue Doppler imaging coupled with high dose dobutamine stress echocardiography for detecting coronary artery stenosis.,
67th Annual Scientific Meeting of the Japanese Circulation Society, Mar. 2003. K Harada, Tomotsugu Tabata, H Tanaka, E Kimura, Tetsuzo Wakatsuki, T Yamamoto, A Saito, K Uehara, N Kageyama, Akiyoshi Nishikado, Masahiro Nomura, Hirotsugu Yamada, Susumu Ito and T Oki :
Longitudinal myocardial displacement and strain rate in hypertrophied heart evaluated by tissue strain imaging with Doppler tissue tracking technique.,
67th Annual Scientific Meeting of the Japanese Circulation Society, Mar. 2003. 原田賢治, 田畑智継, 田中英治, 木村恵理子, 若槻哲三, 山本隆, 斎藤彰浩, 上原康三, 蔭山徳人, 山田博胤, 大木崇 :
高容量ドブタミン負荷試験陽性例の局所壁運動速度分布の変化に関する検討,
第50回日本心臓病学会学術集会, 2002年9月. 田中英治, 田畑智継, 木村恵理子, 原田賢治, 若槻哲三, 山本隆, 斎藤彰浩, 上原康三, 蔭山徳人, 山田博胤, 大木崇 :
冠攣縮性狭心症におけるアセチルコリン負荷試験陰性例の局所心筋収縮能の評価:カラー組織ドプラ法を用いた新しい解析法による検討,
第50回日本心臓病学会学術集会, 2002年9月. H Tanaka, Tomotsugu Tabata, Tetsuzo Wakatsuki, T Yamamoto, A Saito, Hirotsugu Yamada, Susumu Ito and T Oki :
Detection of the subtle changes in the left ventricular myocardial contractility in patients with vasospastic angina during acethylcholine stress test.,
第66日本循環器学会学術集会, Apr. 2002. Tomotsugu Tabata, T Oki, H Tanaka, Tetsuzo Wakatsuki, T Yamamoto, A Saito, Hirotsugu Yamada and Susumu Ito :
Quantitative analysis of the left ventricular segmental contyractility in the normal subjects using newly developed angle-corrected tissue strain imaging.,
第66回日本循環器学会学術集会, Apr. 2002. Tomotsugu Tabata, T Oki, H Tanaka, Tetsuzo Wakatsuki, T Yamamoto, A Saito, Hirotsugu Yamada and Susumu Ito :
Novel index for evaluating wall motion abnormality using newly developed angle-corrected tissue Doppler imaging.,
第66回日本循環器学会学術集会, Apr. 2002. 山本隆, 若槻哲三, 西角彰良, 田中英治, 山田博胤, 田畑智継, 大木崇 :
通常型房室結節リエントリー性頻拍症における遅伝導路に対する高周波アブレーション後の逆行性心房興奮機序の検討,
第49回日本心臓病学会, 2001年9月. 田中英治, 田畑智継, 山田博胤, 松岡雅子, 影治好美, 真鍋和代, 山本隆, 若槻哲三, 大木崇 :
肥大型心筋症における収縮期の左室心筋内運動速度分布:新しく開発した組織ドプラ法の表示方法,
第49回日本心臓病学会, 2001年9月. 田中英治, 田畑智継, 山田博胤, 松岡雅子, 影治好美, 真鍋和代, 山本隆, 若槻哲三, 大木崇 :
心筋の虚血および壊死の非侵襲的評価:心筋内運動速度分布を用いた新しい解析法による検討,
第49回日本心臓病学会, 2001年9月. 田中英治, 田畑智継, 山田博胤, 松岡雅子, 影治好美, 真鍋和代, 山本隆, 若槻哲三, 大木崇 :
高血圧患者の左室弛緩異常におよぼすロサルタンの効果:組織ドプラ法を用いた新しい解析法による検討,
第49回日本心臓病学会, 2001年9月. 若槻哲三, 大木崇, 山本隆, 日浦教和, 多田拓司, 山田博胤, 酒部宏一, 若槻真吾 :
イヌ急性心筋梗塞モデル再灌流後の冠血流速波形の推移と病理所見の関連性,
第8回心血管内イメージング研究会, 2000年12月. 山本隆, 若槻哲三, 森下智文, 多田拓司, 日浦教和, 小野瀬由紀子, 山田博胤, 西角彰良, 大木崇 :
通常型房室結節リエントリー性頻拍症例におけるHis束電位記録部位-冠静脈洞開口部間心房筋の伝導特性に関する検討,
第48回日本心臓病学会, 2000年9月. 山田博胤, 大木崇, 小野瀬由紀子, 松岡雅子, 影治好美, 真鍋和代, 多田拓司, 山本隆, 若槻哲三 :
原発性肺高血圧における肺静脈血流速波形の特徴,
第48回日本心臓病学会, 2000年9月. 山田博胤, 大木崇, 小野瀬由紀子, 松岡雅子, 影治好美, 真鍋和代, 多田拓司, 山本隆, 若槻哲三 :
僧帽弁輪および左室壁運動速度波形を用いた拡大不全心の予後に関する検討,
第48回日本心臓病学会, 2000年9月. 日浦教和, 若槻哲三, 山本隆, 森下智文, 多田拓司, 西角彰良, 小野瀬由紀子, 山田博胤, 大木崇 :
アンジオテンシンⅡ受容体拮抗薬(カンデサルタン)による急性心筋虚血および再灌流時の不整脈予防効果についての検討,
第48回日本心臓病学会, 2000年9月. 山田博胤, 大木崇, 小野瀬由紀子, 松岡雅子, 山本隆, 若槻哲三, 伊東進 :
肥大型心筋症における左室拡張期asynchronyの評価:組織ドプラ法を用いた検討,
第64回日本循環器学会総会, 2000年4月. 山田博胤, 大木崇, 小野瀬由紀子, 松岡雅子, 山本隆, 若槻哲三, 伊東進 :
組織ドプラ法を用いた心アミロイドーシスにおける左室心筋内速度分布の評価:高血圧性肥大心との比較,
第64回日本循環器学会総会, 2000年4月. 松岡雅子, 大木崇, 山田博胤, 小野瀬由紀子, 山本隆, 若槻哲三, 伊東進 :
陳旧性心筋梗塞症における拡張期局所僧帽弁輪運動速度の評価:パルス組織ドプラ法による検討,
第64回日本循環器学会総会, 2000年4月. 松岡雅子, 大木崇, 山田博胤, 小野瀬由紀子, 山本隆, 若槻哲三, 伊東進 :
肥大型心筋症における左室拡張期asynchronyの評価:MRI SPAMM tagging法による検討,
第64回日本循環器学会総会, 2000年4月. 山田博胤, 大木崇, 三代裕一郎, 小野瀬由紀子, 松岡雅子, 影治好美, 真鍋和代, 若槻哲三, 田畑智継 :
陳旧性心筋梗塞症における左室長軸方向の拡張期asynchronyの検出:組織ドプラ法による検討,
第47回日本心臓病学会, 1999年9月. 山田博胤, 大木崇, 三代裕一郎, 小野瀬由紀子, 松岡雅子, 影治好美, 真鍋和代, 若槻哲三, 田畑智継 :
組織ドプラ法による心筋速度勾配を用いた心臓手術後心室中隔異常運動の検討,
第47回日本心臓病学会, 1999年9月. 小野瀬由紀子, 大木崇, 三代裕一郎, 山田博胤, 松岡雅子, 真鍋和代, 影治好美, 田畑智継, 若槻哲三 :
正常者における長軸および短軸方向の左室収縮様式の加齢による変化:組織ドプラ法による壁運動速度波形を用いた検討,
第47回日本心臓病学会, 1999年9月. 山田博胤, 大木崇, 三代裕一郎, 小野瀬由紀子, 松岡雅子, 影治好美, 真鍋和代, 若槻哲三, 田畑智継 :
僧帽弁口血流速波形の心房収縮期波増高例における心房収縮期左室局所壁運動速波形の特徴,
第47回日本心臓病学会, 1999年9月. 小野瀬由紀子, 大木崇, 若槻哲三, 大石佳史, 山田博胤, 豊嶋敏弘, 三代裕一郎, 日浦教和 :
左冠動脈肺動脈起始(Bland-White-Garland症候群)症例における冠血流動態の特徴-Doppler flow wireによる検討-,
第7回体腔内心血管エコー研究会, 1999年8月. 三代裕一郎, 大木崇, 山田博胤, 阿部美保, 小野瀬由紀子, 若槻哲三, 大石佳史, 井内新, 田畑智継, 真鍋和代, 影治好美 :
組織ドプラ法による収縮期左室壁運動速度波形の検討:左室内圧曲線のpeak dP/dtとの比較,
第46回日本心臓病学会, 1998年9月. 福田和代, 大木崇, 井内新, 田畑智継, 山田博胤, 阿部美保, 小野瀬由紀子, 真鍋和代, 影治好美, 若槻哲三, 伊東進 :
組織ドプラ法を用いた心房細動例における収縮期左室後壁運動速度の検討:心周期変動による波高変化とその臨床的意義,
第9回日本心エコー図学会, 1998年4月. 藤永裕之, 若槻哲三, 山田博胤, 豊嶋敏弘, 井形次郎, 酒部宏一, 大石佳史, 西角彰良, 大木崇 :
収縮性心膜炎における冠動脈血流速波形の特徴-心膜切除前後での検討-,
第5回心血管内イメージング研究会, 1997年12月. 田畑智継, 大木崇, 山田博胤, 福田和代, 阿部美保, 小野瀬由紀子, 若槻哲三, 西角彰良, 井内新, 伊東進 :
左心耳機能と血中心房性ナトリウム利尿ペプタイド濃度の関係,
第1回日本心不全学会, 1997年10月. 田畑智継, 大木崇, 山田博胤, 福田和代, 阿部美保, 若槻哲三, 藤永裕之, 酒部宏一, 西角彰良, 井内新 :
左心耳機能と血中心房性ナトリウム利尿ペプタイド濃度の関係,
第45回日本心臓病学会, 1997年9月. 山田博胤, 大木崇, 田畑智継, 阿部美保, 小野瀬由紀子, 若槻哲三, 藤永裕之, 酒部宏一, 西角彰良, 井内新 :
収縮期心膜炎における右室および左室壁運動速度の評価の診断的有用性:組織ドプラ法を用いた検討,
第45回日本心臓病学会, 1997年9月. 田畑智継, 大木崇, 山田博胤, 阿部美保, 若槻哲三, 酒部宏一, 井形次郎, 西角彰良, 井内新, 伊東進 :
組織ドプラ法を用いた左房収縮時のelectrical and mechanical discordanceの検討,
第61回日本循環器学会学術集会, 1997年3月. 山田博胤, 大木崇, 田畑智継, 真鍋和代, 福田和代, 阿部美保, 若槻哲三, 酒部宏一, 井形次郎, 西角彰良, 井内新, 伊東進 :
拡大心における二次性僧帽弁逆流は僧帽弁口および肺静脈血流速波形に影響を与えるか?,
第61回日本循環器学会学術集会, 1997年3月. 酒部宏一, 若槻哲三, 藤永裕之, 井形次郎, 阿部美保, 山田博胤, 田畑智継, 井内新, 西角彰良, 大木崇, 伊東進 :
急性心筋梗塞再灌流直後の冠血流速パターンと病理所見の関係,
第61回日本循環器学会学術集会, 1997年3月. 若槻哲三, 大木崇, 酒部宏一, 井形次郎, 藤永裕之, 西角彰良, 阿部美保, 山田博胤, 田畑智継, 井内新, 伊東進 :
急性心筋梗塞direct PTCA後の冠血流速パターンの推移と左室局所壁運動の改善との関連性,
第61回日本循環器学会学術集会, 1997年3月. 酒部宏一, 若槻哲三, 井形次郎, 藤永裕之, 西角彰良, 阿部美保, 山田博胤, 田畑智継, 井内新, 大木崇, 伊東進 :
急性心筋梗塞direct PTCA後の冠血流速波形の推移と局所壁運動の改善と関連性,
第4回心血管内イメージング研究会, 1996年12月. 酒部宏一, 西角彰良, 若槻哲三, 井形次郎, 井内新, 野村昌弘, 田畑智継, 山田博胤, 大木崇 :
心房細動時の心房内電位測定の除細動成否予測における有用性,
第44回日本心臓病学会, 1996年9月. 酒部宏一, 若槻哲三, 井形次郎, 阿部美保, 山田博胤, 田畑智継, 井内新, 西角彰良, 大木崇, 伊東進 :
急性心筋梗塞再灌流直後の冠血流パターンと心筋微小循環障害およびその病理所見との関連,
第4回体腔内血管エコー研究会, 1996年8月. 田畑智継, 大木崇, 井内新, 真鍋和代, 佐々木美和, 山田博胤, 西角彰良, 若槻哲三, 篠原尚典, 酒部宏一, 福田信夫, 伊東進 :
組織ドプラ法を用いた左室拡張動態の評価:左室圧下降脚時定数Tauとの比較,
第60回日本循環器学会総会, 1996年3月. 酒部宏一, 若槻哲三, 篠原尚典, 西角彰良, 山田博胤, 田畑智継, 井内新, 大木崇 :
梗塞血管再灌流直後の冠血流パターンと心筋微小循環障害との関係:雑種成犬急性心筋梗塞モデルにおける検討,
第3回心血管内イメージング研究会, 1995年12月. 田畑智継, 大木崇, 福田信夫, 井内新, 佐々木美和, 山田博胤, 西角彰良, 若槻哲三, 篠原尚典, 酒部宏一 :
組織ドプラ法を用いた左室弛緩異常の評価:左室圧下降脚時定数との比較,
第43回日本心臓病学会, 1995年9月. 福田信夫, 大木崇, 井内新, 田畑智継, 佐々木美和, 山田博胤, 西角彰良, 若槻哲三, 篠原尚典, 酒部宏一 :
拡張早期左室流入血流伝播速度の臨床的意義の再検討:左室圧下降脚時定数および僧帽弁開放速度との関係,
第43回日本心臓病学会, 1995年9月. 山田博胤, 大木崇, 福田信夫, 井内新, 西角彰良, 野村昌弘, 田畑智継, 生藤博行, 若槻哲三, 篠原尚典, 佐々木美和, 岸史子, 酒部宏一, 伊東進 :
興味ある血行動態を示した心室中部肥大型閉塞性心筋症の一例,
第14回心脈管研究会, 1995年7月.

研究会・報告書

相原弘幸, 坂東遼, 松本遼太, 曽我部公子, Zheng Robert, 髙橋智紀, 西條良仁, 原知也, 門田宗之, 川端豊, 上野理絵, 松浦朋美, 伊勢孝之, 山口浩司, 八木秀介, 山田博胤, 添木武, 若槻哲三, 藤井志朗, 秦広樹, 佐田政隆 :
学生・研修医セッション1(冠動脈)血友病A患者における重症三枝病変に対する冠動脈バイパス術の一例,
第125回日本循環器学会四国地方会, 2024年12月. 伊藤直司, 西條良仁, 手束一貴, 高橋智子, 谷彰浩, 坂東遼, ロバートゼング, 髙橋智紀, 門田宗之, 川端豊, 上野理絵, 原知也, 松浦朋美, 伊勢孝之, 山口浩司, 八木秀介, 山田博胤, 添木武, 若槻哲三, 松本遼太, 秦広樹, 佐田政隆 :
ポスタ-セッション健康診断を契機に発見された巨大冠動脈瘤の一例,
第269回徳島医学会学術集会, 2024年7月. 村上貴寛, 八木秀介, 原知也, 伊勢孝之, 楠瀬賢也, 松浦朋美, 飛梅威, 山口浩司, 山田博胤, 添木武, 若槻哲三, 島袋充生, 赤池雅史, 春藤譲治, 佐田政隆 :
原発性アルドステロン症の診断に有用な臨床所見の検討,
第253回徳島医学会学術集会(平成28年度夏期), 2016年7月. 山上圭, 西條良仁, 楠瀬賢也, 山田博胤, 瀬野弘光, 原知也, 上野理絵, 門田宗之, 齋藤友子, 山﨑宙, 坂東左知子, 伊藤浩敬, 轟貴史, 松浦朋美, 伊勢孝之, 飛梅威, 山口浩司, 八木秀介, 添木武, 若槻哲三, 佐田政隆 :
生体腎移植後における腎静脈-外腸骨静脈間の血流動態変化が一因と考えられた深部静脈血栓症の一例,
第253回徳島医学会学術集会(平成28年度夏期), 2016年7月. 山口泉, 里見淳一郎, 曽我部周, 吉岡正太郎, 中島公平, 木内智也, 兼松康久, 山本雄輝, 山本伸昭, 若槻哲三, 永廣信治 :
OCTを用いて塞栓源を同定しえた一例,
第8回徳島Vascular Imaging研究会, 2016年7月. 曽我部周, 里見淳一郎, 中島公平, 山口泉, 桑山一行, 吉岡正太郎, 永廣信治, 山本伸昭, 若槻哲三 :
光干渉断層法を用いて塞栓源を同定しえた脳梗塞の一例,
第24回NPO法人日本脳神経血管内治療学会中国四国地方会, 2015年9月. 山下雄也, 坂東美佳, 伊勢孝之, 楠瀬賢也, 山田博胤, 原知也, 高島啓, 山﨑宙, 斎藤友子, 坂東左知子, 飛梅威, 山口浩司, 八木秀介, 添木武, 若槻哲三, 木下肇, 藤本鋭貴, 北川哲也, 井上洋行, 佐田政隆 :
収縮期雑音を契機に発見された成人単純型大動脈狭窄症の1例,
第251回徳島医学会学術集会, 2015年8月. 瀬野弘光, 山﨑宙, 八木秀介, 黒部裕嗣, 高森信行, 楠瀬賢也, 伊勢孝之, 山口浩司, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
急激な弁破壊を認めたメチシリン感受性表皮ブドウ球菌による感染性心内膜炎の一例,
第251回徳島医学会学術集会, 2015年8月. 曽我部周, 里見淳一郎, 中島公平, 山口泉, 桑山一行, 吉岡正太郎, 永廣信治, 山本伸昭, 若槻哲三 :
OCTを用いて塞栓源を同定しえた脳梗塞の1例,
第17回徳島脳血管障害カンファレンス, 2015年5月. 松浦朋美, 飛梅威, 添木武, 坂東左知子, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 若槻哲三, 佐田政隆 :
室房ブロックを伴っても持続する2種類の房室結節リエントリー性頻拍を認め，上位共通路の存在が示唆された1例,
第25回カテーテルアブレーション委員会公開研究会, 2013年11月. Takeshi Soeki, T Matsuura, S Bando, E Uematsu, Takayuki Ise, Takeshi Tobiume, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro, I Kishimoto, Kenji Kangawa and Masataka Sata :
Ghrelin protects the heart against ischemia-induced arrhythmia by preserving connexin 43 protein.,
第36回心筋代謝研究会, Jul. 2013. 坂東美佳, 山田博胤, 西尾進, 冨田紀子, 發知淳子, 林修司, 中川摩耶, 玉井利奈, 平田有紀奈, 弘田大智, 小笠原梢, 髙島啓, 山崎宙, 坂東左知子, 伊勢孝之, 仁木敏之, 山口浩司, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
質低下療法による頸動脈プラーク安定化の評価,
第5回T0kushima Young Investigators Conference, 2012年3月. 坂東美佳, 山田博胤, 冨田紀子, 發知淳子, 西尾進, 中川摩耶, 玉井利奈, 平田有紀奈, 弘田大智, 坂東左知子, 伊勢孝之, 仁木敏之, 山口浩司, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 佐田政隆 :
Fabry病の2家系,
第16回中四国心筋症・心不全研究会, 2011年9月. 岩瀬俊, 伊勢孝之, 小笠原梢, 山崎宙, 高島啓, 坂東左知子, 仁木敏之, 楠瀬賢也, 發知淳子, 冨田紀子, 上田由佳, 山口浩司, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 佐田政隆, 髙尾正一郎, 能勢隼人, 原田雅史, 赤池雅史, 足立克仁 :
Duchenne型筋ジストロフィー女性キャリアの心病変検出における心臓MRI検査の有用性,
第16回中四国心筋症・心不全研究会, 2011年9月. 原知也, 岩瀬俊, 高島啓, 山崎宙, 小笠原梢, 坂東左知子, 伊勢孝之, 仁木敏之, 楠瀬賢也, 上田由佳, 冨田紀子, 山口浩司, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 佐田政隆, 赤池雅史, 能勢隼人, 髙尾正一郎, 大塚秀樹, 原田雅史, 西岡安彦 :
心サルコイドーシス診断の手引きにおける各種診断モダリティーの検討,
第16回中四国心筋症・心不全研究会, 2011年9月. 林修司, 山田博胤, 楠瀬賢也, 西尾進, 發知淳子, 冨田紀子, 仁木敏之, 山口浩司, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 佐田政隆 :
高齢者の左室弛緩能に心拍数が与える影響について:僧帽弁口血流速パターンをどう解釈するか,
第1回四国symphony, 2011年7月. 遠藤桂輔, 山田博胤, 楠瀬賢也, 西尾進, 冨田紀子, 三木淳子, 林修司, 玉井利奈, 河野裕美, 平岡葉月, 佐藤光代, 山口浩司, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 赤池雅史, 齋藤憲, 佐田政隆 :
陳旧性心筋梗塞症における心電図左房負荷所見の意義:心エコー・ドプラ法を用いた検討,
心・血管クラスターミニリトリート, 2011年1月. 楠瀬賢也, 山田博胤, 西尾進, 冨田紀子, 林修司, 三木淳子, 仁木敏之, 山口浩司, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
左室内同期不全に対する前負荷の影響拡張型心筋症における下肢陽圧負荷3次元心エコー法を用いた検討,
先進血管エコー研究会, 2010年8月. 遠藤桂輔, 山田博胤, 西尾進, 冨田紀子, 楠瀬賢也, 林修司, 佐藤光代, 平岡葉月, 河野裕美, 三木淳子, 玉井利奈, 山口浩司, 竹谷善雄, 添木武, 若槻哲三, 赤池雅史, 佐田政隆, 齋藤憲 :
心電図異常を指摘され，心エコー検査で発見された左室緻密化障害の1例,
第3回蔵本エコーカンファレンス, 2010年7月. 楠瀬賢也, 山田博胤, 西尾進, 冨田紀子, 遠藤桂輔, 仁木敏之, 山口浩司, 小柴邦彦, 八木秀介, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
心房細動におけるE/e'の計測法:dual Doppler法を用いた検討,
第8回先進血管エコー研究会, 2009年8月. 山中森晶, 山田博胤, 楠瀬賢也, 冨田紀子, 仁木敏之, 山口浩司, 小柴邦彦, 八木秀介, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆, 西尾進 :
脳卒中患者における心エコー検査の現状:徳島大学病院SCU搬送例における検討,
第11回徳島脳卒中研究会, 2009年2月. 山中森晶, 山田博胤, 楠瀬賢也, 冨田紀子, 仁木敏之, 山口浩司, 小柴邦彦, 八木秀介, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆, 西尾進 :
脳卒中患者における心エコー検査の現状:徳島大学病院SCU搬送例における検討,
脳卒中研究会, 2009年2月. 若槻哲三, 山口浩司, 小柴邦彦, 河野智仁, 西角彰良, 木村恵理子, 田中英治, 田畑智継, 野村昌弘 :
アトルバスタチンの冠動脈石灰化病変に対する作用の検討 -冠動脈内温度変化の観点から-,
第52回日本心臓病学会学術集会, 2004年9月.

(要約): 冠動脈内温度は局所炎症反応を反映しているが，石灰化が著明な病変では，炎症終息して局所温が低値であり，アトルバスタチンの抗炎症効果も小さくなる．

山口浩司, 野村昌弘, 小柴邦彦, 木村恵理子, 渡部智紀, 河野智仁, 田中英治, 若槻哲三, 田畑智継, 西角彰良 :
肝硬変症と動脈硬化との関連性,
第52回日本心臓病学会学術集会, 2004年9月.

(要約): 高齢者肝硬変例における脈波伝播速度と頚動脈エコーとを検討した．肝硬変ではNO産生のため，PWVは見かけ上，マスクされていると思われる．

河野智仁, 野村昌弘, 木村恵理子, 渡部智紀, 山口浩司, 小柴邦彦, 田中英治, 若槻哲三, 田畑智継, 西角彰良 :
ロサルタンの発作性心房細動抑制効果について P波同期加算平均心電図を用いた検討,
第52回日本心臓病学会学術集会, 2004年9月.

(要約): ロサルタンは心房の線維化を抑制する．抗不整脈薬単独投与群ではこのような器質的リモデリングは抑制できず，ARBの併用が望ましいと考えられた．

河野智仁, 野村昌弘, 渡部智紀, 山口浩司, 小柴邦彦, 木村恵理子, 田中英二, 若槻哲三, 田畑智継, 西角彰良 :
本態性高血圧症におけるカンデサルタンの左室拡張機能，心筋線維化および脈波伝播速度におよぼす影響,
第52回日本心臓病学会学術集会, 2004年9月.

(要約): カンデサルタンは心筋線維化のマーカーを改善させ血管弾力性にも好影響を与えると思われた．さらに，左室拡張機能の改善も期待される薬剤である．

河野智仁, 野村昌弘, 木村恵理子, 渡部智紀, 山口浩司, 小柴邦彦, 田中英治, 若槻哲三, 田畑智継, 西角彰良 :
16列マルチスライスCTを用いた冠動脈プラークの評価,
第52回日本心臓病学会学術集会, 2004年9月.

(要約): 冠動脈造影でソフトプラークの存在する例では急性冠症候群発症のリスクを有する．16列マルチスライスCT による冠動脈プラークの診断を行った．

山口浩司, 野村昌弘, 木村恵理子, 小柴邦彦, 河野智仁, 田中英治, 若槻哲三, 田畑智継, 西角彰良, 渡部智紀 :
トータル·ヘルス·プロモーション·プランにおける運動療法とホモシステインとの関連性,
第52回日本心臓病学会学術集会, 2004年9月.

(要約): トータル·ヘルス·プロモーション·プラン検診を受診した症例について検討した．最大酸素摂取量は，ホモシステイン濃度と負の相関関係にあった．

山口浩司, 野村昌弘, 木村恵理子, 小柴邦彦, 河野智仁, 田中英治, 若槻哲三, 田畑智継, 西角彰良, 渡部智紀 :
アミオダロンにて持続性心室頻拍をコントロールできた一例:平均加算化心電図によるresponderの評価,
第52回日本心臓病学会学術集会, 2004年9月.

(要約): 平均加算化心電図を用いて心室頻拍へのアミオダロンのresponderとnon-responderとの鑑別が可能であった症例を経験した．

小柴邦彦, 野村昌弘, 木村恵理子, 渡部智紀, 山口浩司, 河野智仁, 田中英治, 若槻哲三, 田畑智継, 西角彰良 :
閉塞性睡眠時無呼吸における高感度CRP，血管接着因子および炎症性サイトカインの関連性およびアンギオテンシンⅡ受容体拮抗薬における影響,
第52回日本心臓病学会学術集会, 2004年9月.

(要約): 閉塞性睡眠時無呼吸(OSAS)と血管接着因子および炎症サインとの関連性を検討した．hs-CRP，ICAM-1，IL-6を増加し，ARBはそのリスクは軽減した．

小柴邦彦, 野村昌弘, 木村恵理子, 渡部智紀, 山口浩司, 河野智仁, 田中英治, 若槻哲三, 田畑智継, 西角彰良 :
平均加算化心電図法および123I-BMIPP心筋シンチグラフィによるC型肝炎ウイルスによる心筋障害の検出,
第52回日本心臓病学会学術集会, 2004年9月.

(要約): C型肝硬変症例について，平均加算化心電図法と123I-BMIPP心筋シンチを用いて，持続的C型肝炎ウイルス感染による心筋障害がみられるか検討した．

小柴邦彦, 野村昌弘, 木村恵理子, 渡部智紀, 山口浩司, 河野智仁, 田中英治, 若槻哲三, 田畑智継, 西角彰良 :
16列マルチスライスCTを用いた4次元表示法による左室収縮能および拡張能評価,
第52回日本心臓病学会学術集会, 2004年9月.

(要約): 16列マルチスライスCT (MSCT)による左室収縮能および拡張能は，LVGやUCGと有意な相関を示したが，梗塞罹患部位により解離がみられる例があった．

河野智仁, 野村昌弘, 木村恵理子, 渡部智紀, 山口浩司, 小柴邦彦, 田中英治, 若槻哲三, 田畑智継, 西角彰良 :
心筋梗塞モデルラットにおけるG-CSFの心筋再生効果についての検討:梗塞血管の開存は必要か?,
第52回日本心臓病学会学術集会, 2004年9月.

(要約): G-CSFによる梗塞巣抑制効果は，心筋梗塞再灌流モデルラットには認められたが，完全結紮による心筋梗塞群では程度は少なかった．

渡部智紀, 野村昌弘, 小柴邦彦, 木村恵理子, 山口浩司, 河野智仁, 田中英治, 若槻哲三, 田畑智継, 西角彰良 :
肥満と食後熱産生，インスリン抵抗性および交感神経活性との関連,
第52回日本心臓病学会学術集会, 2004年9月.

(要約): 肥満との関連を報告されている食後熱産生は，インスリン抵抗性および交感神経活動と関連があると考えられた．

野村昌弘, 山口浩司, 渡部智紀, 木村恵理子, 小柴邦彦, 河野智仁, 田中英二, 若槻哲三, 田畑智継, 西角彰良 :
Ca拮抗薬アゼルニジピンの酸化ストレス抑制効果の臨床的検討,
第52回日本心臓病学会学術集会, 2004年9月.

(要約): アゼルニジピンは，酸化ストレス抑制ならびにサイトカインの変動に伴い，内皮機能の改善が期待できる臓器保護作用をきたすCa拮抗薬と考えられた．

河野智仁, 野村昌弘, 木村恵理子, 山口浩司, 小柴邦彦, 田中英治, 若槻哲三, 田畑智継, 西角彰良, 伊東進 :
グリメピリドの炎症性サイトカインにおよぼす影響と抗動脈硬化作用について脈波伝播速度(baPWV)とaugmentation index (AI) を用いた検討,
第4回臨床脈波研究会, 2004年5月.

(要約): グリメピリドは，アディポネクチンの増加¥，TNF-αを低下させ，インスリン抵抗性を改善させる．さらに，IL-6とhs-CRPを抑制し，動脈硬化を抑制した．

Kouji Yamaguchi, Masahiro Nomura, Akiyoshi Nishikado, Tomotsugu Tabata, Tetsuzo Wakatsuki, Eiji Tanaka, Tomohito Kawano, Kanji Kusunoki, Norihito Kageyama, Eriko Kimura, Shinichiro Miyazaki, Junji Yamashita, Eiko Uemura, Susumu Ito, Yutaka Nakaya and Ken Saito :
Effect of CPAP therapy in hypertensive patients with obstructive sleep apnea: Analysis of automonic activity, adhesion molecules and inflammatory signs,
The 68th Annual Scientific Meeting of the Japanese Circulation Society, Mar. 2004.

(要約): CPAP治療は，自律神経活動，血管接着因子および炎症性サインを低下させ，高血圧合併のOSASの心血管および脳血管障害を軽減させると考えられた．

Tomohito Kawano, Masahiro Nomura, Akiyoshi Nishikado, Tomotsugu Tabata, Tetsuzo Wakatsuki, H Tanaka, Kanji Kusunoki, Norihito Kageyama, Eriko Kimura, Shinichiro Miyazaki, Junji Yamashita, Eiko Uemura, Susumu Ito, Yutaka Nakaya and Ken Saito :
The anti-atherosclerosis effect of glimepiride: Examination by inflammatory cytokines, pulse wave velocity (baPWV) and agumentation index (AI),
The 68th Annual Scientific Meeting of the Japanese Circulation Society, Mar. 2004.

(要約): グリメピリドはアディポネクチンを増加しTNF-αを低下させ，インスリン抵抗性を改善し，炎症性サイトカインを抑制すし抗動脈硬化的に作用した．

Tomohito Kawano, Masahiro Nomura, Akiyoshi Nishikado, Tomotsugu Tabata, Tetsuzo Wakatsuki, H Tanaka, Kanji Kusunoki, Norihito Kageyama, Eriko Kimura, Shinichiro Miyazaki, Junji Yamashita, Eiko Uemura, Susumu Ito, Yutaka Nakaya and Ken Saito :
Electrophysiological improvement of the atrium by losartan potassium (Nu-Lotan®) in hypertensive patients.,
The 68th Annual Scientific Meeting of the Japanese Circulation Society, Mar. 2004.

(要約): ニューロタン®における心房興奮を平均加算化心電図を用いて電気的興奮における作用について検討し，心房における電気生理的改善効果が期待された．

Junji Yamashita, Masahiro Nomura, Akiyoshi Nishikado, Tomotsugu Tabata, Tetsuzo Wakatsuki, H Tanaka, Kanji Kusunoki, Tomohito Kawano, Kouji Yamaguchi, Norihito Kageyama, Eriko Kimura, Shinichiro Miyazaki, Eiko Uemura, Susumu Ito, Yutaka Nakaya and Ken Saito :
Mechanism of ST segment depression during exercise test in patients with liver cirrhosis.,
The 68th Annual Scientific Meeting of the Japanese Circulation Society, Mar. 2004.

(要約): 肝硬変症で増加する女性ホルモンはジギタリスに類似し，冠動脈微小動脈の収縮作用のため，冠動脈に有意狭窄がなくとも運動負荷時にST低下をきたす．

Kanji Kusunoki, Masahiro Nomura, Tomohito Kawano, Norihito Kageyama, Eriko Kimura, Koji Yamaguchi, H Tanaka, Tetsuzo Wakatsuki, Tomotsugu Tabata, Akiyoshi Nishikado and Susumu Ito :
Clinical efficacy of azelnidipine on sympathetic activities: Examination using spectral analysis of heart rate/blood pressure variabilities and 123I-MIBG myocardial scintigraphy,
The 68th Annual Scientific Meeting of the Japanese Circulation Society, Mar. 2004.

(要約): アゼルニジピンはCa拮抗薬でありながら，反射性の交感神経亢進をきたしにくい．心拍·血圧変動解析およびMIBG心筋シンチで自律神経を検討した．

Masahiro Nomura, Akiyoshi Nishikado, Tomotsugu Tabata, Tetsuzo Wakatsuki, H Tanaka, Kanji Kusunoki, Tomohito Kawano, Norihito Kageyama, Eriko Kimura, Shinichiro Miyazaki, Junji Yamashita, Eiko Uemura, Susumu Ito, Yutaka Nakaya and Ken Saito :
Current density map in ventricular repolarization phase in diabetic patients.,
The 68th Annual Scientific Meeting of the Japanese Circulation Society, Mar. 2004.

(要約): 糖尿病例の心室再分極異常について検討した．Current density mapにより，心電図で検出される前の異常を早期に検出できると思われた．

河野智仁, 野村昌弘, 西角彰良, 田畑智継, 若槻哲三, 田中英二, 楠完治, 山口浩司, 木村恵理子, 蔭山徳人, 宮崎晋一郎, 山下潤司, 上村英子, 伊東進 :
高血圧症例におけるニューロタン®の心房電気生理的な改善効果についての検討,
2003年度心不全と不整脈フォーラム, 2003年12月.

(要約): ロサルタンは心房の線維化を抑制する．平均加算化心電図見では，心房の伝導障害が改善され，心房細動にはARBの投与が望ましいと考えられた．

野村昌弘, 中屋豊, 上村英子, 伊賀彰子, 澤優子, 蔭山徳人, 斎藤彰浩, 河野智仁, 楠完治, 木村恵理子, 田中英二, 若槻哲三, 田畑智継, 西角彰良, 齋藤憲 :
糖尿病における心筋障害の早期検出心磁図current density mapによる評価,
第51回日本心臓病学会学術集会, 2003年9月.

(要約): 心磁図により糖尿病性心筋障害の早期診断が可能かどうか，current density mapにより検討した．異常電流が心電図で捉えられる以前に早期に検出できた．

田中英治, 田畑智継, 木村恵理子, 原田顕治, 若槻哲三, 斎藤彰浩, 楠完治, 蔭山徳人, 野村昌弘 :
低用量ドブタミン負荷心エコー法による精度よい心筋viabilityの評価ストレイン·イメージング法を用いた定量的評価,
第51回日本心臓病学会学術集会, 2003年9月.

(要約): 低用量ドブタミン負荷心エコー法にストレス·イネージング法を適応すると，壁運動スコアを用いた評価では検出しえない心筋のviabilityを鋭敏に評価できた．

野村昌弘, 上村英子, 中屋豊, 伊賀彰子, 蔭山徳人, 斎藤彰浩, 河野智仁, 楠完治, 若槻哲三, 田畑智継, 西角彰良, 齋藤憲 :
ストレス下における自律神経及びQT dispersionの変動内視鏡下総胆管処置中の検討,
第51回日本心臓病学会学術集会, 2003年9月.

(要約): 内視鏡下総胆管処置中には自律神経活動のアンバランスとQT dispersionの増大がみられるため，偶発症にまで進展する可能性が示唆された．

木村恵理子, 田畑智継, 田中英治, 原田顕治, 若槻哲三, 斎藤彰浩, 楠完治, 蔭山徳人, 野村昌弘 :
ストレインイメージング法を用いた左室拡張能の評価:ROI trackingを併用したストレインレートと従来の心筋運動速度の比較による検討,
第51回日本心臓病学会学術集会, 2003年9月.

(要約): ROI trackingを併用すると，より正確なストレインレートが得られた．拡張早期ストレインレートは各種病態における左室拡張能を感度よく評価した．

田中英治, 田畑智継, 木村恵理子, 原田顕治, 若槻哲三, 斎藤彰浩, 楠完治, 蔭山徳人, 野村昌弘 :
心臓全体の運動や牽引の影響を除外した左室収縮能の評価従来の組織ドプラ法とストレインイメージング法の比較,
第51回日本心臓病学会学術集会, 2003年9月.

(要約): 高用量ドブタミン負荷エコーにストレインイメージング法を適応すると，心臓全体の運動や牽引の影響を受けることなく心筋虚血を定量的に検出できた．

原田顕治, 田畑智継, 田中英治, 木村恵理子, 若槻哲三, 斎藤彰浩, 楠完治, 蔭山徳人, 野村昌弘 :
ストレインイメージング法を用いた肥大心における左室長軸方向の局所心筋収縮動態の評価に関する検討,
第51回日本心臓病学会学術集会, 2003年9月.

(要約): 肥大心の長軸方向の収縮力はASHの中隔および後側壁でも低下していた．さらに，ASHの心室中隔の収縮動態は不均一で，A弁閉鎖後も収縮していた．

田畑智継, 田中英治, 木村恵理子, 原田顕治, 若槻哲三, 斎藤彰浩, 楠完治, 蔭山徳人, 野村昌弘 :
肥大型心筋症の長期経年変化:当院における25年間の追跡調査,
第51回日本心臓病学会学術集会, 2003年9月.

(要約): 当院における肥大型心筋症の25年間の心臓超音波検査にて心筋肥厚様式の追跡調査を行った．心筋肥厚様式に変化を生じる例が多いことが判明した．

斎藤彰浩, 若槻哲三, 蔭山徳人, 楠完治, 西角彰良, 田中英治, 木村恵理子, 田畑智継, 野村昌弘 :
冠動脈中等度狭窄病変における経年変化と冠動脈内温度との関連性,
第51回日本心臓病学会学術集会, 2003年9月.

(要約): 冠動脈局所プラーク壁温度は，その時点までの局所炎症反応を反映しており，病変進行·退縮と連動している可能性が示唆された．

蔭山徳人, 野村昌弘, 斎藤彰浩, 楠完治, 河野智仁, 木村恵理子, 田中英治, 若槻哲三, 田畑智継, 西角彰良 :
陳旧性心筋梗塞症における閉塞性睡眠時無呼吸(SAS)とQT dispersionとの関連,
第51回日本心臓病学会学術集会, 2003年9月.

(要約): OSASを有する陳旧性心筋梗塞症例では無呼吸発作時にはQTc dispersionの増大がみられ，致死性不整脈発生の引き金となる可能性性が示唆された．

田中英治, 田畑智継, 木村恵理子, 原田顕治, 若槻哲三, 斎藤彰浩, 楠完治, 蔭山徳人, 野村昌弘 :
高用量ドブタミン負荷心エコー法による精度よい冠動脈病変の検出心筋内速度分布図を用いた新しい定量的評価,
第51回日本心臓病学会学術集会, 2003年9月.

(要約): 高用量ドブタミン負荷心エコー法に心筋内速度分布を適応すると，視覚的評価では検出できない微小な心筋収縮力の低下を鋭敏に検出できた．

楠完治, 野村昌弘, 蔭山徳人, 木村恵理子, 斎藤彰浩, 河野智仁, 田中英治, 若槻哲三, 田畑智継, 西角彰良, 中屋豊, 齋藤憲 :
閉塞性睡眠時無呼吸と動脈硬化との関連性脈波伝播速度(PWV)による検討,
第51回日本心臓病学会学術集会, 2003年9月.

(要約): 動脈硬化に対して多変量解析では，OSASの存在が独立した危険因子であり，relative riskも高かった．OSASは独立して動脈硬化の進展と関連性がある．

河野智仁, 野村昌弘, 蔭山徳人, 斎藤彰浩, 楠完治, 木村恵理子, 田中英治, 若槻哲三, 田畑智継, 西角彰良, 中屋豊, 齋藤憲 :
高齢者における胸部痛に対する硝酸薬の投与の影響,
第51回日本心臓病学会学術集会, 2003年9月.

(要約): 高齢者の胸痛患者はGERDの場合がある．亜硝酸薬は胃運動の低下，副交感神経の低下と交感神経の増加をきたし，消化管運動を抑制し症状を増悪させる．

山下潤司, 野村昌弘, 森下智文, 武市直樹, 蔭山徳人, 河野智仁, 楠完治, 若槻哲三, 田畑智継, 西角彰良, 中屋豊, 齋藤憲 :
肝硬変症における運動負荷試験偽陽性の成因,
第51回日本心臓病学会学術集会, 2003年9月.

(要約): 肝硬変症で増加する女性ホルモンはジギタリスに類似し，冠動脈微小動脈の収縮作用のため，冠動脈に有意狭窄がなくとも運動負荷時にST低下をきたす．

木村恵理子, 田畑智継, 田中英治, 原田顕治, 若槻哲三, 斎藤彰浩, 楠完治, 蔭山徳人, 野村昌弘 :
高血圧心における左室形態と左室局所心筋収縮能の関係心筋内速度分布図を用いた検討,
第51回日本心臓病学会学術集会, 2003年9月.

(要約): 高血圧心における左室経の拡大は，ポンプ機能のみならず局所心筋のcontracitilityも低下するこたが，心筋内速度較差を解析することにより判明した．

若槻哲三, 斎藤彰浩, 蔭山徳人, 楠完治, 西角彰良, 木村恵理子, 田中英治, 田畑智継, 野村昌弘 :
冠動脈ステント植え込み後の冠動脈内温度と再狭窄の関連性,
第51回日本心臓病学会学術集会, 2003年9月.

(要約): 温度センサー付カイドワイアでの冠動脈の局所のプラーク壁温度はその時点までの局所炎症反応を反映しており，再狭窄進行と連動している可能性が示唆された．

河野智仁, 野村昌弘, 蔭山徳人, 斎藤彰浩, 楠完治, 木村恵理子, 田中英治, 若槻哲三, 田畑智継, 西角彰良, 中屋豊, 齋藤憲 :
グリメピリドの動脈硬化抑制効果サイトカイン及び脈波伝播速度による検討,
第51回日本心臓病学会学術集会, 2003年9月.

(要約): グリメピリドはTNF-αを低下させ，血管内皮障害やミトコンドリア障害を改善させ，血管の炎症の消退により動脈硬化が抑制されると考えられた．

山下潤司, 野村昌弘, 森下智文, 武市直樹, 上村英子, 友兼優子, 伊賀彰子, 蔭山徳人, 楠完治, 河野智仁, 若槻哲三, 田畑智継, 西角彰良, 伊東進, 中屋豊 :
肝硬変症における運動負荷時ST低下は虚血を反映するのか?,
第53回循環器負荷研究会, 2003年8月.

(要約): 肝硬変症で増加する女性ホルモンはジギタリスに類似し，冠動脈微小動脈の収縮作用のため，冠動脈に有意狭窄がなくとも運動負荷時にST低下をきたす．

楠完治, 野村昌弘, 西角彰良, 蔭山徳人, 斎藤彰浩, 木村恵理子, 河野智仁, 田中英治, 若槻哲三, 田畑智継, 大塩敦郎, 玉木克佳, 福野天, 井上博, 筒井朱美, 柴田啓志, 本田浩仁, 伊東進 :
高齢者において肝硬変症は動脈硬化の加速因子となるのか?脈波伝播速度，一酸化窒素および自律神経活動による検討,
第28回老年消化器病研究会, 2003年6月.

(要約): PWVの増加は肝硬変症の動脈硬化進行の関連性を示唆するが，肝硬変症ではhyperdynamic状態がみられ，Child Cでは動脈硬化進行がマスクされると思われた．

楠完治, 野村昌弘, 西角彰良, 蔭山徳人, 斎藤彰浩, 木村恵理子, 河野智仁, 田中英治, 若槻哲三, 田畑智継, 大塩敦郎, 玉木克佳, 福野天, 井上博, 筒井朱美, 柴田啓志, 本田浩仁, 伊東進 :
肝硬変症は動脈硬化を加速させるのか?脈波伝播速度，一酸化窒素および自律神経活動による検討,
第3回臨床動脈波研究会, 2003年6月.

(要約): 脈波伝播速度，NOおよび自律神経活動による検討で，肝硬変症ではNOの産生によるhyperdynamic状態がみられ，PWVに影響するとも考えられた．

Kanji Kusunoki, Kohzou Uehara, Masahiro Nomura, Akiyoshi Nishikado, K Harada, N Kageyama, Yutaka Nakaya, Ken Saito, Tetsuzo Wakatsuki, Tomotsugu Tabata and Susumu Ito :
Detection of myocardial microvasular disorders using dynamic 99mTc-MIBI SPECT.,
67th annual scientific meeting of the Japanese Circulation society, Mar. 2003.

(要約): 糖尿病性微小循環障害例を用いて検討した．心筋微小循環障害は，99mTc-MIBIダイナミックSPECTのtime activity curveで検出されると考えられた．

Kenji Harada, Masahiro Nomura, Akiyoshi Nishikado, Kouzoh Uehara, Kanji Kusunoki, A Saito, N Kageyama, Eriko Kimura, E Tanaka, Tetsuzo Wakatsuki, Tomotsugu Tabata, Yutaka Nakaya and Susumu Ito :
Effect of glimepiride on coronary blood flow reserve: evaluation by % uptake increases during exercise myocardial scintigraphy,
67th annual scientific meeting of the Japanese Circulation society, Mar. 2003.

(要約): glimepirideはミトコンドリアKATPチャンネルを阻害しないため，糖尿病性微小循環障害による冠動脈血行異常を改善させることが明らかとなった．

Kozo Uehara, Masahiro Nomura, Akiyoshi Nishikado, Kenji Harada, Kanji Kusunoki, N Kageyama, Yutaka Nakaya, Ken Saito, Tetsuzo Wakatsuki, Tomotsugu Tabata and Susumu Ito :
Relationship among high-sensitive CRP, maximum oxygen uptake and insulin resistance.,
67th annual scientific meeting of the Japanese Circulation society, Mar. 2003.

(要約): 高血圧症に閉塞性睡眠時無呼吸(SAS)が合併すると，交感神経活性がさらに亢進して，動脈硬化や高血圧がさらに進行する可能性があると思われた．

N Kageyama, Kohzou Uehara, Masahiro Nomura, Akiyoshi Nishikado, K Harada, K Kusunoki, Tetsuzo Wakatsuki, Tomotsugu Tabata, Ken Saito, Yutaka Nakaya and Susumu Ito :
Influence of sleep apnea on autonomic nervous activity in patients with essential hypertension,
67th annual scientific meeting of the Japanese Circulation society, Mar. 2003.

(要約): 高血圧症に閉塞性睡眠時無呼吸(SAS)が合併すると，交感神経活性がさらに亢進して，動脈硬化や高血圧がさらに進行する可能性があると思われた．

宮島等, 野村昌弘, 近藤幸, 若槻哲三, 西角彰良, 齋藤憲, 大木崇, 伊東進, 原田雅史, 西谷弘, 中屋豊 :
摂食による冠動脈血流波形の変化:胃電図および冠動脈シネMRAを用いた検討,
第49回循環器負荷研究会, 2000年2月.

(要約): 食事による胃運動の亢進に伴い，冠動脈に有意狭窄を認める症例では冠動脈血流は有意に低下し，食後の心筋虚血と胃運動との関連性が示唆された．

近藤幸, 野村昌弘, 由岐中道子, 若槻哲三, 西角彰良, 齋藤憲, 大木崇, 中屋豊 :
大動脈弁狭窄症におけるCine MRアンギオを用いた左室-大動脈間圧較差の測定,
第46回日本心臓病学会学術集会, 1998年9月.

(要約): MRIを用いて流速が測定できる．大動脈弁狭窄症におけるCine MRアンギオを用いた左室-大動脈間圧較差の測定を行いカテーテル圧と良好に相関した．

由岐中道子, 野村昌弘, 近藤幸, 岸史子, 若槻哲三, 西角彰良, 齋藤憲, 大木崇, 伊東進, 原田雅史, 田岡良章, 中屋豊 :
Magnetic Resonance Coronary Angiography (MRCA)によるPTCA前後での冠動脈血流速度-再狭窄診断への応用-,
第61回日本循環器学会総会学術集会, 1997年3月.

(要約): Magnetic Resonance Coronary Angiography (MRCA)によるPTCA前後での冠動脈血流速度は，治療後で増加し，再狭窄診断の応用が可能と思われた．

野村昌弘, 中屋豊, 三好由貴子, 若槻哲三, 西條哲也, 伊東進, 森博愛, 田村逸郎, 和田昌夫, 藤田智, 高江勉 :
正常心磁図QRS波の電流dipoleのMRI画像上への表示,
第29回日本臨床生理学会総会, 1992年10月.

(要約): 心磁図法は電流源の部位推定が可能である．正常心磁図QRS波の電流dipoleのMRI画像上へ表示すると，心室中隔から左室への電流の動きがみられた．

中屋豊, 齋藤憲, 野村昌弘, 三好由貴子, 若槻哲三 :
血管平滑筋カリウム電流と収縮·弛緩-血管作動物質の効果-,
第11回心脈管研究会, 1992年8月.

(要約): 培養血管平滑筋細胞では，ATP感受性Kチャネル(KATP)が血管のトーヌスの調節に関与し，またこの抑制により，血管が収縮することを明らかにした．

野村昌弘, 中屋豊, 三好由貴子, 若槻哲三, 伊東進, 森博愛, 上野慎一, 松崎健司, 西谷弘, 田村逸郎, 和田昌夫, 藤田智, 高江勉 :
正常例の初期QRS波のdipoleの位置推定-心電図同期MRI画像上への表示-,
第7回日本生体磁気学会, 1992年6月.

(要約): 正常例の初期QRS波のdipoleの位置を心磁図で推定した．心電図同期MRI画像上へ表示すると，その電流源は心室中隔に位置した．

野村昌弘, 中屋豊, 三好由貴子, 若槻哲三, 伊東進, 森博愛, 上野慎一, 松崎健司, 西谷弘, 田村逸郎, 和田昌夫, 藤田智, 高江勉 :
心磁図法による心室最早期興奮部位の推定-磁界分布図と体表面電位図·心表面マッピングとの対比-,
第7回日本生体磁気学会, 1992年6月.

(要約): 心臓磁界を用いて，心室性不整脈およびWPW症候群の心室最早期興奮部位をMRI画像上に重畳すると心臓カテーテルや体表面電位図所見と一致した．

若槻哲三, 中屋豊, 三好由貴子, 野村昌弘, 齋藤憲, 伊東進 :
冠動脈血管平滑筋の2種のKチャンネルに対するVasopressinの作用,
第56回日本循環器学会総会, 1992年3月.

(要約): Vasopressinには，ATP感受性KチャンネルとCa2+依存性Kチャンネルの2種類のKチャンネルに対し異なる作用を持つ．

野村昌弘, 中屋豊, 三好由貴子, 若槻哲三, 齋藤憲, 西角彰良, 浜井一人, 坂東重信, 伊東進, 日浅芳一, 相原令 :
心室頻拍およびWPW症候群の心室最早期興奮部位の推定-心臓磁界およびMRIを用いた部位推定-,
第56回日本循環器学会総会, 1992年3月.

(要約): 心臓磁界を用いて，心室頻拍およびWPW症候群の心室最早期興奮部位をMRI画像上に重畳すると心臓カテーテルや体表面電位図所見と一致した．

野村昌弘, 中屋豊, 日比野敏行, 三好由貴子, 若槻哲三, 大木崇, 伊東進 :
マラソン前後での血中遊離型および硫酸抱合型カテコラミンの変動,
第34回循環器負荷研究会, 1992年2月.

(要約): マラソン前後で血中遊離型·硫酸抱合型カテコラミンの変動を検討した．硫酸抱合型カテコラミンが多く存在して，負荷時に遊離型変換されると思われた．

藤野和也, 中屋豊, 片山まり子, 若槻哲三, 三好由貴子, 野村昌弘, 浜井一人, 坂東重信, 森博愛 :
体表面磁界分析による不整脈発生源の推定,
かなえ新薬研究会, 1991年11月. 野村昌弘, 中屋豊, 三好由貴子, 若槻哲三, 西角彰良, 浜井一人, 坂東重信, 日浅芳一, 相原令 :
心磁図法による心室性期外収縮の発生源の推定,
第8回日本心電学会, 1991年10月.

(要約): 心磁図法により心室性期外収縮の発生源を3次元的に推定し，心電図同期MRI画像上にマッピングすると，体表面電位図や心臓カテーテル所見と一致した．

中屋豊, 野村昌弘, 若槻哲三, 三好由貴子, 西角彰良, 坂東重信, 伊東進, 中安紀美子 :
Single moving dipoleによる左室負荷の診断,
第40回ベクトル心電図研究会, 1991年6月.

(要約): 心磁図計測により，電流の実際の大きさを推定可能である．電流dipoleの増大を診断することにより，左室肥大の診断に感度·特異度ともよく診断できる．

Ayaka Kobayashi, Masahiro Nomura, Yuko Tomokane, Takashi Kawaguchi, Kunihiko Koshiba, Koji Yamaguchi, Tomohito Kawano, Tetsuzo Wakatsuki, Tomotsugu Tabata, Akiyoshi Nishikado, Susumu Ito and Yutaka Nakaya :
A Patient with sustained ventricular tachycardia:identification of a responder to aminodarone using signal-averaged electrocardiogram,
The Journal of Medical Investigation : JMI, Vol.51, No.3-4, 247-253, Aug. 2004.

(要約): A 75-year-old man suffered sustained ventricular tachycardia with syncopal attack. Ventricular tachycardias appeared repeatedly, and an electrical defibrillator was used after an anti-arrhythmic drug, such as lidocaine or mexiletine, proved ineffective. The tachycardias had multiple origins, and the signal-averaged electrocardiogram (SAECG) showed ventricular late potential before the administration of amiodarone. After administration, the filtered QRS and duration of the late potential increased, but the recurrence of tachycardias was suppressed. The reason for this is thought to be that amiodarone blocked the sodium channel and delayed conduction, consequently blocking reentry, because amiodaron has antiarrhymic properties with a prolongation of refractoriness and minimal effect on conduction velocity in ventricular myocardium, and inhibits sympathetic activity, and blocks L-type calcium channel besides the depression of the fast sodium channel. In this case, SAECG predicted to some degree whether or not this patient's ventricular tachycardia would respond to amiodarone.
(キーワード): Aged / Amiodarone / Anti-Arrhythmia Agents / Electrocardiography / Humans / Male / Signal Processing, Computer-Assisted / Tachycardia, Ventricular
(徳島大学機関リポジトリ): ● Metadata: 110750
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.51.247
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15460915; ● Search Scopus @ Elsevier (PMID): 15460915; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.51.247

(徳島大学機関リポジトリ: 110750, DOI: 10.2152/jmi.51.247, PubMed: 15460915)

特許: 研究者総覧に該当データはありませんでした。
作品: 八木秀介, 福田大受, 平田有紀奈, GANBAATAR BYAMBASUREN, Arief Rahadian, 伊勢孝之, 楠瀬賢也, 山田博胤, 山口浩司, 松浦朋美, 飛梅威, 曽我朋宏, 添木武, 若槻哲三, 川人伸次, 佐田政隆 :
【糖尿病専門医に必要な心不全の知識update】SGLT2阻害薬と心不全(解説/特集),
糖尿病・内分泌代謝科, Vol.52, No.3, 257-264, 2021年11月.
補助金・競争的資金: 研究者番号（60322260）による検索

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専門分野・研究分野: 内科学 (Internal Medicine)
循環器病学 (Cardiovascular Medicine)
所属学会・所属協会: 社団法人日本内科学会
社団法人日本循環器学会
日本心臓病学会
日本心血管インターベンション学会
日本心血管画像動態学会
日本心血管カテーテル治療学会
委員歴・役員歴: 日本心血管インターベンション学会 (評議員·指導医)
日本心血管画像動態学会 (評議員)
受賞: 1992年1月, 康楽賞 (財団法人三木康楽会)
2013年4月, 第24回日本心エコー図学会学術集会海外学会発表優秀論文賞 (日本心エコー図学会)
2013年5月, 第102回日本循環器学会中国・四国合同地方会研修医部門最優秀賞 (社団法人日本循環器学会)
2013年5月, 第102回日本循環器学会中国・四国合同地方会コメディカル部門最優秀賞 (社団法人日本循環器学会)
2013年8月, ESC Congress 2013 The Top Score Poster Award (European Society of Cardiology)
2013年12月, 第103回日本循環器学会四国地方会学生・研修医セッション奨励賞 (社団法人日本循環器学会)
2014年4月, 第25回日本心エコー図学会学術集会ベストポスター賞 (日本心エコー図学会)
2014年7月, 第248回徳島医学会学術集会(平成25年度冬期)若手奨励賞 (徳島医学会)
2014年7月, 第248回徳島医学会学術集会(平成25年度冬期) 若手奨励賞 (徳島医学会)
2014年9月, 第62回日本心臓病学会学術集会優秀賞(優秀演題セッション口演1 一般) (日本心臓病学会)
2014年12月, 第105回日本循環器学会四国地方会コメディカルセッション奨励賞 (社団法人日本循環器学会)
2015年3月, 平成26年度表彰論文優秀賞 (公益財団法人福田記念医療技術振興財団)
2015年9月, 第63回日本心臓病学会学術集会若手症例Presenter賞 (日本心臓病学会)
2016年3月, 第5回日本循環器学会循環器臨床研究奨励賞(症例報告部門) (社団法人日本循環器学会)
2016年3月, 第3回日本循環器学会循環器イメージング賞 (社団法人日本循環器学会)
2016年6月, 第108回日本循環器学会中国・四国合同地方会「研修医奨励賞」 (日本心臓病学会)
2016年7月, 第253回徳島医学会学術集会(平成28年度夏期)「若手奨励賞」 (徳島医学会)
2016年9月, 第64回日本心臓病学会学術集会優秀演題セッション(医師部門)優秀賞 (日本心臓病学会)
2016年9月, KSC2016 Young Investigator's Award (The 60th Annual Scientific Meeting of The Korean Society of Cardiology)
2016年12月, 第109回日本循環器学会四国地方会学生・研修医奨励賞 (社団法人日本循環器学会)
2017年3月, Young Investigator's Award (Clinical Research ) (社団法人日本循環器学会)
2017年9月, 優秀演題賞 (第24回日本心血管インターベーション治療学会中国・四国地方会)
2017年9月, Young Investigators Award 最優秀賞 (第65回日本心臓病学会学術集会)
2018年6月, 研修医奨励賞 (第112回日本循環器学会中国・四国合同地方会)
2018年9月, Young Investigator's Award (第25回日本心血管インターベンション治療学会中国四国地方会)
2021年12月, 若手研究奨励賞 (第119回日本循環器学会四国地方会若手研究奨励賞)
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Jグローバル最終確認日: 2024/12/21 01:30
氏名（漢字）: 若槻哲三
氏名（フリガナ）: ワカツキテツゾウ
氏名（英字）: Wakatsuki Tetsuzo
所属機関: 徳島大学助手

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researchmap最終確認日: 2024/12/22 03:15
氏名（漢字）: 若槻哲三
氏名（フリガナ）: ワカツキテツゾウ
氏名（英字）: Wakatsuki Tetsuzo
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登録日時: 2003/11/25 00:00
更新日時: 2024/12/18 10:23
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所属ID: 0344003000
所属: 徳島大学
部署: 徳島大学病院材料部
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