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山田博胤

徳島大学

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2024年12月20日更新

職名: 特任教授
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学歴: 1998/3: 徳島大学大学院医学研究科修了(医博修了)
学位: 博士(医学) (徳島大学) (1998年3月)
職歴・経歴: 〜: 徳島大学助手, 病院 (-2007.3.)
2007/4: 徳島大学助教, 病院 (-2007.12.)
2008/1: 徳島大学助教, 大学院ヘルスバイオサイエンス研究部 (-2008.4.)
2008/5: 徳島大学助教, 病院 (-2010.6.)
2010/7: 徳島大学講師, 病院 (-2017.10.)
2017/11: 徳島大学特任教授, 大学院医歯薬学研究部 (-2023.6.)
2024/1: 徳島大学特任教授, 大学院医歯薬学研究部

専門分野・研究分野: 医学 (Medicine)

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2024年12月20日更新

専門分野・研究分野: 医学 (Medicine)
担当経験のある授業科目: 循環器コース(3年) (学部)
疾病学2 (学部)
臨床医学 (学部)
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研究者総覧で最新データを確認する

2024年12月20日更新

専門分野・研究分野: 医学 (Medicine)

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著書

楠瀬賢也, Robert Zheng, 山田博胤, 佐田政隆 :
左室駆出率計測の標準化に向けた展望,
2023年10月. 松本力三, 西尾進, 平田有紀奈, 森田沙瑛, 湯浅麻美, 山尾雅美, 柿本拓海, 齋藤裕, 楠瀬賢也, 山田博胤, 上原久典, 島田光生, 佐田政隆 :
術前の画像検査で肝細胞癌と診断された肝炎症性偽腫瘍の1例,
(一社)日本超音波検査学会, 2023年10月.

(要約): 症例は70代,男性.近医の定期的な血液検査で胆道系酵素の上昇を認めたため,腹部超音波検査を施行したところ,肝左葉内側区に腫瘤を認めた.当院消化器外科に紹介となり,肝内側区切除術が施行され,肝細胞癌と診断された.術後7ヵ月,当院で経過観察目的に施行した造影CT検査で肝左葉外側区に新たに腫瘤を認め,再度精査となった.血液検査では,γ-GTPの軽度上昇を認めるのみで,腫瘍マーカーの上昇は認めなかった.術前の精査目的に施行した腹部超音波検査では,肝左葉外側区(S2)に18×16mm大の腫瘤を認めた.境界明瞭,輪郭は後面が整,前面がやや不整,内部エコーは等輝度で不均質であった.辺縁に比較的厚い低エコー帯を伴っていた.心拍動の影響で血流シグナルの評価は困難であった.腹部造影CT検査では,肝左葉外側区(S2)に2cm大の腫瘤を認め,早期濃染および洗い出しが確認された.本症例は,術前の超音波検査で,肝細胞癌としては非典型的な像を呈していたが,他の画像所見および既往歴から肝細胞癌の再発が否定できず,肝部分切除術が施行され,肝炎症性偽腫瘍と診断された.本症例のように肝細胞癌のリスクが高い症例においても,新規に腫瘤を認めた際には,超音波検査でその特徴を注意深く観察し,典型像と異なる場合には肝炎症性偽腫瘍も鑑別疾患の一つとして考慮した方がよいと考える.(著者抄録)
(キーワード): *肝炎(画像診断,外科的療法,病理学) 肝細胞癌肝切除 MRI 腫瘍再発鑑別診断術前評価超音波診断 X線CT *肉芽腫(画像診断,外科的療法,病理学) *肉芽腫-形質細胞(画像診断,外科的療法,病理学) Gadoxetic Acid(診断的利用) Azan染色 *肝肉芽腫(画像診断,外科的療法,病理学) 腹部CT ヒト高齢者(65∼79) 男
(出版サイトへのリンク): ● Publication site (DOI): 10.11272/jss.405
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.11272/jss.405

(DOI: 10.11272/jss.405) 山田博胤, 楠瀬賢也 :
1. 循環器領域 (心エコー) のトピックス - Onco-cardiology, point-of-care ultrasound, そして人工知能 (AI),
株式会社インナービジョン, 東京, 2020年6月. 山田博胤 :
心エコーポケットノート第6版,
アスリード, 東京, 2019年12月. 伊藤浩敬, 山田博胤 :
Ⅴ心臓疾患心膜炎の分類と疫学,
2019年9月. 山田博胤, JPOCUSインストラクター :
領域横断チョイあてエコー活用術,
株式会社メディカ出版, 大阪, 2019年8月. 山田博胤, 藤原美佳 :
III循環器領域,
文光堂, 2019年4月. 山田博胤, 西尾進, 楠瀬賢也 :
徳大超音波センターのオキテ100,
文光堂, 東京, 2019年3月. 伊藤浩敬, 山田博胤 :
心膜炎の分類と疫学,
2019年. 山田博胤, 西尾進 :
第14章下肢腫脹鑑別 2)腫脹，浮腫とは,
日本超音波検査学会監修/佐藤洋編, 2019年. 山田博胤 :
こんなに役立つpoint of care超音波,
株式会社メジカルビュー社, 東京, 2017年6月. 楠瀬賢也, 山田博胤 :
心エコーハンドブック心不全: 竹中克，戸出浩之編, --- 左室駆出率が低下した心不全と左室駆出率が保たれた心不全 ---,
株式会社金芳堂, 東京, 2017年5月. 山田博胤 :
心エコー臨床のギモン厳選50,
株式会社メディカ出版, 大阪, 2017年4月. 山田博胤 :
新肺高血圧症診療マニュアル,
南江堂, 東京, 2017年3月. 山田博胤, 大木崇 :
心エコーポケットノート第5版,
アスリード株式会社, 東京, 2015年. 山田博胤 :
心膜疾患収縮性心膜炎,
株式会社中山書店, 2015年. 山田博胤 :
ベッドサイド検査を行うにあたって,
医歯薬出版株式会社, 2015年. 山田博胤 :
心臓弁膜症・感染性心内膜炎 (Chapter 2 循環器疾患),
医歯薬出版株式会社, 東京, 2014年5月. 山田博胤 :
Capter2 循環器疾患心臓弁膜症・感染症心内膜炎,
医歯薬出版株式会社, 2014年5月. 山田博胤, 福田信夫, 大木崇 :
後天性弁膜疾患,
株式会社医学書院, 2014年4月. 山田博胤 :
Capter2 循環器疾患心臓弁膜症・感染性心内膜炎,
医歯薬出版株式会社, 2014年. 山田博胤, 福田信夫, 大木崇 :
後天性弁膜疾患,
株式会社医学書院, 2014年. 島袋充生, M Dagvasumberel, 石田昌義, 松本幸子, 小塚智沙代, 平良伸一, 屋比久浩市, 八木秀介, 福田大受, 山田博胤, 添木武, 若槻哲三, 親泊政一, 益埼裕章, 佐田政隆 :
異所性脂肪と2型糖尿病・心臓血管病【特集生活の質(QOL:Quality of life)を高める医療最前線ー難治な病気に光明が見えた!ー】,
徳島医学会, 徳島, 2013年4月.

(要約): There is evidence supporting the notion that excess abdominal fat is predictive of insulin resistance and the presence of related metabolic abnormalities currently referred to as the metabolic syndrome (MetS). Despite the fact that abdominal obesity is a highly prevalent feature of MetS, the mechanisms by which abdominal obesity is causally related to MetS are not fully elucidated. Besides visceral fat accumulation, ectopic lipid deposition, especially in the liver and skeletal muscle, has been implicated in the pathophysiology of diabetes, insulin resistance and obesity-related disorders. In addition, ectopic fat deposition play a critical role in the heart components such as (1) circulatory and locally recruited fat, (2) intra-and extra-myocellular fat, (3) perivascular fat, and (4) pericardial fat. In this review, the contribution of ectopic lipid deposition to global cardiometabolic risk is discussed via possible mechanisms including adipocytokine, insulin resistance and lipotoxicity.
(キーワード): Ectopic fat deposition / Diabetes mellitus / Cardiovascular diseases / Obesity / Metabolic syndrome / Lipotoxicity
(徳島大学機関リポジトリ): ● Metadata: 109609
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1050302172854384256

(徳島大学機関リポジトリ: 109609, CiNii: 1050302172854384256) 楠瀬賢也, 山田博胤 :
労作時と夜間にも息切れを訴える55歳男性,
文光堂, 東京, 2012年. 弘田大智, 西尾進, 山田博胤 :
大動脈二尖弁と上行大動脈拡大決定版超音波検査テクニックマスター∼頭部・頸部・胸部・上肢編∼,
株式会社メディカ出版, 大阪, 2012年. 山田博胤 :
僧帽弁狭窄症僧帽弁狭窄をきたす疾患とそのみかた,
文光堂, 2011年. 山田博胤 :
経食道心エコー図検査(TEE)はどのような場合に行うのですか?,
株式会社メジカルビュー社, 2011年. 山田博胤 :
動脈硬化の診断に頸動脈エコーのほか心エコー図検査も役立ちますか?,
株式会社メジカルビュー社, 2011年. 山田博胤 :
正常亜型(その所見があっても異常とはいえないもの)にはどういうものがありますか?,
株式会社メジカルビュー社, 2011年. 楠瀬賢也, 山田博胤 :
心嚢液貯留がどのくらいで心タンポナーデと診断すればいいですか?,
株式会社メジカルビュー社, 2011年. 楠瀬賢也, 山田博胤 :
Pre-capillary PH, post capillary PHの診断はどうすればいいですか?,
株式会社メジカルビュー社, 2011年. 楠瀬賢也, 山田博胤 :
心房細動の患者さんではどのように計測すればいいですか?(EF，左室径，拡張能，弁膜症評価),
株式会社メジカルビュー社, 2011年. 山田博胤 :
組織ドプラ法の5W1H,
株式会社メジカルビュー社, 東京, 2011年. 楠瀬賢也, 山田博胤 :
左室拡張不全をきたす疾患，心膜疾患,
文光堂, 2010年9月. 楠瀬賢也, 山田博胤 :
心筋梗塞後に下腿浮腫を認めた70歳男性,
2010年7月. 山田博胤, 楠瀬賢也 :
弁置換術後にむくみを自覚した72歳女性,
2010年7月. 西尾進, 山田博胤 :
左室拡張不全の診断，下大静脈・肝静脈血流速波形,
文光堂, 2010年. 山田博胤, 大木崇 :
左室拡張不全の診断，肺静脈血流速波形,
文光堂, 2010年. 山田博胤, 大木崇 :
左室拡張不全の診断，僧帽弁口血流速波形,
文光堂, 2010年. 楠瀬賢也, 山田博胤 :
循環器臨床サピア1,
2009年. 大木崇, 山田博胤 :
心エコーポケットノート第3版,
イーアドバンス, 2009年. 山田博胤 :
心エコーポケットノート,
イーアドバンス, 東京, 2007年. 大木崇, 森一博, 若槻哲三, 山田博胤, 福田信夫 :
心エコー·ドプラ法の臨床第2版,
株式会社医学書院, 東京, 2001年9月. 大木崇, 山田博胤 :
3．循環器組織ドプラ法,
株式会社医学書院, 東京, 2000年. Nobuo Fukuda, Takashi Oki, Arata Iuchi, Tomotsugu Tabata, Hirotsugu Yamada, N Takeichi, H Shinohara and T Soeki :
Right heart flow dynamics after tricuspid valve annuloplasty. Characteristics and time course.,
Japanese Heart Journal Association, Tokyo, 1998. 大木崇, 田畑智継, 山田博胤, 井内新 :
パルス・連続波および組織ドプラ法による心機能の評価,
日本臨床, 大阪, 1997年. 大木崇, 山田博胤, 福田信夫, 皆越真一 :
S字状中隔心,
日本臨床, 大阪, 1996年.

論文

Masaaki Hayashi, Takeshi Soeki, Yasuhiro Noda, Daiki Tamagami, Keisuke Morinishi, Yusuke Chikata, Tomoko Takahashi, Tomomi Matsuura, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Hirotsugu Yamada, Tetsuzo Wakatsuki and Masataka Sata :
Risk Factors for Intraoperative Instability in Sedated Patients Undergoing Pulmonary Vein Isolation Ablation,
International Heart Journal, Vol.65, No.6, 1020-1024, 2024.

(要約): Persistent or paroxysmal atrial fibrillation is typically treated with pulmonary vein isolation (PVI) ablation under deep sedation with propofol. Intraoperative hemodynamic or respiratory instability often interferes with the surgical procedure. We retrospectively investigated risk factors in 80 patients who underwent their first PVI ablation for atrial fibrillation at our hospital. Background and echocardiography findings were collected from their electronic charts and the questionnaires they completed during hospitalization. Total intraoperative propofol dose and bolus injections (total number and volume) were defined as surrogate measures of patient instability. Single and stepwise multiple regression were performed using each measure as the dependent variable. When total propofol dose was employed as the dependent variable, significant associations were observed with drinking status (P < 0.05) and body mass index (BMI) (P < 0.05). When total number or volume of intravenous propofol boluses were each used as the dependent variable, significant associations were noted with age (P < 0.05) and BMI (P < 0.05). Separately, statistical analyses were conducted using total propofol dose or total number of bolus injections as the dependent variable and echocardiography parameters as independent variables. A significant association was detected between total dose and left atrial dimension (P < 0.05). These results suggested that younger age, higher BMI (obesity), and current drinking status adversely affect patient stability under deep sedation. To ensure safe ablation, physicians should pay attention to these risk factors when administering deep sedation for PVI.
(キーワード): Humans / Male / Atrial Fibrillation / Female / Pulmonary Veins / Middle Aged / Risk Factors / Retrospective Studies / Propofol / Catheter Ablation / Aged / Deep Sedation / Body Mass Index / Intraoperative Complications / Echocardiography
(徳島大学機関リポジトリ): ● Metadata: 119657
(出版サイトへのリンク): ● Publication site (DOI): 10.1536/ihj.24-152
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 39537166; ● Search Scopus @ Elsevier (PMID): 39537166; ● Search Scopus @ Elsevier (DOI): 10.1536/ihj.24-152

(徳島大学機関リポジトリ: 119657, DOI: 10.1536/ihj.24-152, PubMed: 39537166) Kenya Kusunose, T Imai, A Tanaka, M Doi, Y Koide, K Fukumoto, T Kadokami, M Ohishi, H Teragawa, N Ohte, Hirotsugu Yamada, Masataka Sata and K Node :
Effects of ipragliflozin on left ventricular diastolic function in patients with type 2 diabetes: A sub-analysis of the PROTECT trial,
Journal of Cardiology, Vol.84, No.4, 246-252, 2024.

(要約): We hypothesized that the beneficial effects of sodium-glucose cotransporter-2 (SGLT2) inhibitors on diastolic function might depend on baseline left ventricular (LV) systolic function. To investigate the effects of SGLT2 inhibitors on LV diastolic function in patients with type 2 diabetes mellitus (T2DM), we conducted a post-hoc sub-study of the PROTECT trial, stratifying the data according to LV ejection fraction (LVEF) at baseline. After excluding patients without echocardiographic data at baseline or 24 months into the PROTECT trial, 31 and 38 patients with T2DM from the full analysis dataset of the PROTECT trial who received ipragliflozin or no SGLT2 inhibitor (control), respectively, were included. The primary endpoint was a comparison of the changes in echocardiographic parameters and N-terminal pro-brain natriuretic peptide levels from baseline to 24 months between the two groups stratified according to baseline LVEF. Differences in diastolic functional parameters (e' and E/e') were noted between the two groups. Among the subgroups defined according to median LVEF values, those with higher LVEF (≥60 %) who received ipragliflozin appeared to have a higher e' and lower E/e' than did those who received the standard of care with no SGLT2 inhibitor, indicating longitudinal improvements between baseline and follow up (p = 0.001 and 0.016, respectively). Ipragliflozin generally improved LV diastolic function in patients with type 2 diabetes, the extent of this improvement might appear to vary with LV systolic function.
(キーワード): Humans / Diabetes Mellitus, Type 2 / Male / Female / Thiophenes / Sodium-Glucose Transporter 2 Inhibitors / Middle Aged / Ventricular Function, Left / Aged / Glucosides / Diastole / Natriuretic Peptide, Brain / Stroke Volume / Echocardiography / Peptide Fragments / Ventricular Dysfunction, Left
(徳島大学機関リポジトリ): ● Metadata: 119605
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jjcc.2024.02.002
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38378130; ● Search Scopus @ Elsevier (PMID): 38378130; ● Search Scopus @ Elsevier (DOI): 10.1016/j.jjcc.2024.02.002

(徳島大学機関リポジトリ: 119605, DOI: 10.1016/j.jjcc.2024.02.002, PubMed: 38378130) Shusuke Yagi, Ryosuke Miyamoto, Masayoshi Tasaki, Hiroyuki Morino, Ryuji Otani, Muneyuki Kadota, Takayuki Ise, Hiroki Yamazaki, Kenya Kusunose, Koji Yamaguchi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Daiju Fukuda, Mitsuharu Ueda and Masataka Sata :
The APOA1 p.Leu202Arg variant potentially causes autosomal recessive cardiac amyloidosis.,
Human Genome Variation, Vol.11, No.1, 2024.

(要約): ApoA-I amyloidosis is an extremely rare form of systemic amyloidosis that commonly involves the heart, kidneys, and liver. ApoA-I amyloidosis is caused by amyloidogenic variants of APOA1 that are inherited in an autosomal dominant manner. Here, we report a 69-year-old man with sporadic cardiac amyloidosis who was born to consanguineous parents and carried a homozygous variant of p.Leu202Arg in APOA1.
(徳島大学機関リポジトリ): ● Metadata: 119580
(出版サイトへのリンク): ● Publication site (DOI): 10.1038/s41439-024-00288-7
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 39152105; ● Summary page in Scopus @ Elsevier: 2-s2.0-85201547622

(徳島大学機関リポジトリ: 119580, DOI: 10.1038/s41439-024-00288-7, PubMed: 39152105, Elsevier: Scopus) Shusuke Yagi, Muneyuki Kadota, Ryo Bando, Ryosuke Miyamoto, Hiroyuki Morino, Akiyoshi Kakutani, Yoshiaki Kubo, Takayuki Ise, Rie Ueno, Tomoya Hara, Kenya Kusunose, Koji Yamaguchi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Daiju Fukuda and Masataka Sata :
Pulmonary Arterial Hypertension in Neurofibromatosis Type 1: A Case with a Novel NF1 Gene Mutation,
Internal Medicine, 2024.

(要約): Neurofibromatosis type 1 (NF1) is an autosomal dominant multi-organ disease. The clinical manifestations include not only skin lesions and malignant tumors but also lung complications, including pulmonary arterial hypertension (PAH). However, the association between gene mutations in NF1 and the occurrence of PAH has not yet been elucidated. We herein report a case of isolated PAH in a 67-year-old woman with NF1, presumably caused by a novel heterozygous mutation, c.4485_4486delinsAT (p.Lys1496Ter), in the NF1 gene.
(徳島大学機関リポジトリ): ● Metadata: 119521
(出版サイトへのリンク): ● Publication site (DOI): 10.2169/internalmedicine.3856-24
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38987187; ● Search Scopus @ Elsevier (PMID): 38987187; ● Search Scopus @ Elsevier (DOI): 10.2169/internalmedicine.3856-24

(徳島大学機関リポジトリ: 119521, DOI: 10.2169/internalmedicine.3856-24, PubMed: 38987187) Yoshihito Saijyo, Kenya Kusunose, TOMONORI Takahashi, Hirotsugu Yamada, Masataka Sata, Kimi Sato, Noor Albakaa, Tomoko Ishizu, Yoshihiro Seo and JSE TAVI investigators :
Impact of Transcatheter Aortic Valve Replacement on Cardiac Reverse Remodeling and Prognosis in Mixed Aortic Valve Disease,
Journal of the American Heart Association, Vol.13, No.4, e033289, 2024.

(要約): The management of mixed aortic valve disease (MAVD), defined as the concomitant presence of aortic stenosis (AS) and aortic regurgitation, remains a clinical challenging. The present study assessed the impact of transcatheter aortic valve replacement (TAVR) on cardiac geometry and prognosis in patients with MAVD. A retrospective multicenter TAVR registry was conducted, including patients who underwent TAVR for severe symptomatic AS between January 2015 and March 2019. Patients were subdivided into 2 groups according to concomitant presence of moderate or more severe aortic regurgitation as the MAVD group, and with mild or less severe aortic regurgitation as the isolated AS group. The primary outcome was a composite of cardiovascular death and rehospitalization due to cardiovascular causes. A total of 1742 patients (isolated AS, 1522 patients; MAVD, 220 patients) were included (84.0±5.2 years). Although MAVD exhibited significantly larger left ventricular volumes and higher left ventricular mass index at the TAVR procedure than isolated AS (respectively, <0.001), MAVD showed a greater improvement of left ventricular volumes and left ventricular mass index after TAVR (respectively, ≤0.001). During a median follow-up of 747 days, 301 patients achieved the primary event. The prognosis post-TAVR was comparable between the 2 groups (log-rank =0.65). Even after adjustment using propensity score matching to reduce the potential bias between the 2 groups, similar results were obtained for the entire cohort. Despite more advanced cardiac remodeling in MAVD at the time of TAVR compared with isolated AS, a greater improvement of cardiac reverse remodeling was found in MAVD, and the prognosis following TAVR was comparable between the 2 groups.
(キーワード): Humans / Transcatheter Aortic Valve Replacement / Aortic Valve / Aortic Valve Insufficiency / Treatment Outcome / Risk Factors / Aortic Valve Stenosis / Prognosis / Retrospective Studies / Severity of Illness Index / Ventricular Function, Left
(出版サイトへのリンク): ● Publication site (DOI): 10.1161/JAHA.123.033289
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38362873; ● Search Scopus @ Elsevier (PMID): 38362873; ● Search Scopus @ Elsevier (DOI): 10.1161/JAHA.123.033289

(DOI: 10.1161/JAHA.123.033289, PubMed: 38362873) N Yamaguchi, Yukina Hirata, Susumu Nishio, TOMONORI Takahashi, Yoshihito Saijo, Muneyuki Kadota, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Masataka Sata and Kenya Kusunose :
Pulmonary Pressure-flow responses to exercise in heart failure treated with angiotensin receptor neprilysin inhibitor.,
International Journal of Cardiology, Vol.400, 131789, 2024.

(要約): The role of the angiotensin receptor neprilysin inhibitor (ARNI) in cardiac function, particularly its impact on pulmonary circulation, remains underexplored. Recent studies have described abnormal mean pulmonary artery pressure (mPAP)-cardiac output (CO) responses as having the potential to assess the disease state. The aim of this study was to assess the effects of ARNI on pulmonary circulation in heart failure. We measured echocardiographic parameters post 6-min walk (6 MW) and compared the changes with baseline and follow-up. Our hypothesis was that pulmonary pressure-flow relationship of the pulmonary circulation obtained by 6 MW stress echocardiography would be improved with treatment. We prospectively enrolled 39 heart failure patients and conducted the 6 MW test indoors. Post-6 MW echocardiography measured echocardiographic variables, and CO was derived from electric cardiometry. Individualized ARNI doses were optimized, with follow-up echocardiographic evaluations after 1 year. Left ventricular (LV) volume were significantly reduced (160.7 ± 49.6 ml vs 136.0 ± 54.3 ml, P < 0.001), and LV ejection fraction was significantly improved (37.6 ± 11.3% vs 44.9 ± 11.5%, P < 0.001). Among the 31 patients who underwent 6 MW stress echocardiographic study at baseline and 1 year later, 6 MW distance increased after treatment (380 m vs 430 m, P = 0.003). The ΔmPAP/ΔCO by 6 MW stress decreased with treatment (6.9 mmHg/L/min vs 2.8 mmHg/L/min, P = 0.002). The left atrial volume index was associated with the response group receiving ARNI treatment for pulmonary circulation. Initiation of ARNI was associated with improvement of left ventricular size and LVEF. Additionally, the 6 MW distance increased and the ΔmPAP/ΔCO was improved to within normal range with treatment.
(徳島大学機関リポジトリ): ● Metadata: 118925
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.ijcard.2024.131789
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38246422; ● Search Scopus @ Elsevier (PMID): 38246422; ● Search Scopus @ Elsevier (DOI): 10.1016/j.ijcard.2024.131789

(徳島大学機関リポジトリ: 118925, DOI: 10.1016/j.ijcard.2024.131789, PubMed: 38246422) S Yamaguchi, M Maeda, K Oba, G Maimaituxun, O Arasaki, Shusuke Yagi, Kenya Kusunose, Takeshi Soeki, Hirotsugu Yamada, Daiju Fukuda, H Masuzaki, Masataka Sata and Michio Shimabukuro :
Sex differences in the association between epicardial adipose tissue volume and left atrial volume index,
BMC Cardiovascular Disorders, Vol.24, No.1, 46, 2024.

(要約): Sex disparities in the association between epicardial adipose tissue volume (EATV) and cardiovascular disease have been reported. The sex-dependent effects of EATV on left atrial (LA) size have not been elucidated. Consecutive 247 subjects (median 65 [interquartile range 57, 75] years; 67% of men) who underwent multi-detector computed tomography without significant coronary artery disease or moderate to severe valvular disease were divided into two groups: patients with sinus rhythm (SR) or atrial fibrillation (AF). Sex differences in the association between the EATV index (EATVI) (mL/m) and LA volume index (LAVI) in 63 SR (28 men and 35 women) and 184 AF (137 men and 47 women) patients were evaluated using univariate and multivariate regression analyses. In overall that includes both men and women, the relationship between EATVI and LAVI was not significantly correlated for patients with SR and AF. The relationship between EATVI and LAVI differed between men and women in both SR and AF groups. In SR patients, there was a positive relationship between EATVI and LAVI in men, but not in women. In contrast, in patients with AF, a negative relationship was found between EATVI and LAVI in women, whereas no association was found in men. We evaluated sex differences in the association between EATVI and LAVI in patients with either SR or AF, and found a positive relationship in men with SR and a negative relationship in women with AF. This is the first report to evaluate sex differences in the relationship between EATVI and LAVI, suggesting that EAT may play a role, at least in part, in sex differences in the etiology of AF.
(キーワード): Humans / Female / Male / Epicardial Adipose Tissue / Sex Characteristics / Heart Atria / Atrial Fibrillation / Atrial Appendage / Adipose Tissue
(徳島大学機関リポジトリ): ● Metadata: 118911
(出版サイトへのリンク): ● Publication site (DOI): 10.1186/s12872-023-03569-1
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38218772; ● Search Scopus @ Elsevier (PMID): 38218772; ● Search Scopus @ Elsevier (DOI): 10.1186/s12872-023-03569-1

(徳島大学機関リポジトリ: 118911, DOI: 10.1186/s12872-023-03569-1, PubMed: 38218772) Munkhtsetseg Tserensonom, Shusuke Yagi, Takayuki Ise, Yutaka Kawabata, Muneyuki Kadota, Tomoya Hara, Kenya Kusunose, Koji Yamaguchi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Lipoprotein (a) is a risk factor of aortic valve calcification in patients with a risk of atherosclerosis,
The Journal of Medical Investigation : JMI, Vol.70, No.3.4, 450-456, 2023.

(要約): Aortic valve calcification (AVC), which causes aortic stenosis (AS), is more common in elderly persons. Controlling for conventional risk variables did not, however, reduce the incidence of AS. Thus, residual risk factors of AS should be identified. We enrolled 513 patients who underwent coronary angiography with computed tomography because of suspicion of coronary artery disease (CAD) or ruling out of CAD before aortic valve replacement. Calcium volume was calculated with a commercially available application. Conventional and lipid-related risk factors including serum levels of Lp(a) were evaluated for all patients. Calcium volume and Lp(a) levels were significantly higher in patients who underwent aortic valve replacement than in those who did not. A single regression analysis showed that the calcium volume was positively associated with age and the Lp(a) levels and negatively associated with the estimated glomerular filtration rate. No statistical significance was observed for other risk factors, including oxidized low-density lipoprotein, omega-3 fatty acids levels. The multiple regression analysis revealed that age (P<0.001), female sex (P<0.05), Lp(a) (P<0.01), and hemoglobin A1c (P<0.01) were determinants of the calcium volume. The area under the curve in receiver operating characteristic analysis of Lp(a) for implementation of AVR was 0.65 at an Lp(a) cut-off level of 16 mg/dL. In conclusion, the serum Lp(a) level is a potent risk factor of AVC in patients with high risk of atherosclerosis. J. Med. Invest. 70 : 450-456, August, 2023.
(キーワード): Humans / Female / Aged / Aortic Valve / Lipoprotein(a) / Calcium / Aortic Valve Stenosis / Atherosclerosis / Risk Factors / Coronary Artery Disease
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.70.450
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37940531; ● Search Scopus @ Elsevier (PMID): 37940531; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.70.450

(DOI: 10.2152/jmi.70.450, PubMed: 37940531) PT Pham, Oyunbileg Bavuu, JR Kim-Kaneyama, XF Lei, T Yamamoto, K Otsuka, Kumiko Suto, Kenya Kusunose, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Michio Shimabukuro, GN Barber, Masataka Sata and Daiju Fukuda :
Innate Immune System Regulated by Stimulator of Interferon Genes, a Cytosolic DNA Sensor, Regulates Endothelial Function,
Journal of the American Heart Association, Vol.12, No.22, e030084, 2023.

(要約): Background Sterile inflammation caused by metabolic disorders impairs endothelial function; however, the underlying mechanism by which hyperglycemia induces inflammation remains obscure. Recent studies have suggested that stimulator of interferon genes (STING), a key cytosolic DNA sensor in the innate immune system, contributes to the pathogenesis of inflammatory diseases. This study examines the role of the STING in endothelial dysfunction in streptozotocin-induced diabetic mice. Methods and Results Injection of streptozotocin promoted the expression of STING and DNA damage markers in the aorta of wild-type mice. Streptozotocin elevated blood glucose and lipid levels in both wild-type and STING-deficient mice, which showed no statistical differences. Genetic deletion of STING ameliorated endothelial dysfunction as determined by the vascular relaxation in response to acetylcholine (<0.001) and increased endothelial nitric oxide synthase phosphorylation in the aorta (<0.05) in STZ-injected mice. Endothelium-independent vascular response to sodium nitroprusside did not differ. Treatment with a direct STING agonist, cyclic GMP-AMP, or mitochondrial DNA increased inflammatory molecule expression (eg, and ) and decreased endothelial nitric oxide synthase phosphorylation in human umbilical vein endothelial cells, partially through the STING pathway. Cyclic GMP-AMP significantly impaired endothelial function of aortic segments obtained from wild-type mice, which was ameliorated in the presence of C-176, a STING inhibitor, or a neutralizing interferon-β antibody. Furthermore, the administration of C-176 ameliorated endothelial dysfunction in STZ-induced diabetic mice (<0.01). Conclusions The DNA damage response regulated by STING impairs endothelial function. STING signaling may be a potential therapeutic target of endothelial dysfunction caused by hyperglycemia.
(徳島大学機関リポジトリ): ● Metadata: 119425
(出版サイトへのリンク): ● Publication site (DOI): 10.1161/JAHA.123.030084
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37947148; ● CiNii @ 国立情報学研究所 (CRID): 1360863109951763328; ● Summary page in Scopus @ Elsevier: 2-s2.0-85178405175

(徳島大学機関リポジトリ: 119425, DOI: 10.1161/JAHA.123.030084, PubMed: 37947148, CiNii: 1360863109951763328, Elsevier: Scopus) TOMONORI Takahashi, H Iwano, K Shibayama, T Kitai, H Tanaka, Hirotsugu Yamada, Masataka Sata and Kenya Kusunose :
The Clinical Utility of Noninvasive Forrester Classification in Acute Heart Failure from PREDICT Study,
The American Journal of Cardiology, Vol.207, 75-81, 2023.

(要約): The Forrester classification plays a crucial role in comprehending the underlying pathophysiology of heart failure (HF) and is employed to categorize the severity and predict the outcomes of patients with acute HF. Our objective was to assess the predictive value of the Forrester classification, based on noninvasive hemodynamic measurements obtained through Doppler echocardiography at admission, in forecasting the short-term prognosis posthospitalization of patients with acute HF. Patients were recruited for the Prospect trial to elucidate the utility of EchocarDIography-based Cardiac ouTput in acute heart failure (PREDICT) study, a multicenter, prospective study conducted in Japan. Participants were stratified into 4 profiles using cardiac index (CI) and early mitral filling velocity (E)/early-diastolic mitral annular velocity (e') ratio obtained from Doppler echocardiography upon admission (profile I: CI >2.2, E/e' ≤15, profile II: CI >2.2, E/e' >15, profile III: CI ≤2.2, E/e' ≤15, profile IV: CI ≤2.2, E/e' >15). The primary composite outcome of the study was all-cause mortality or worsening HF during the 14 days of hospitalization. Cox proportional hazards model analysis was employed to identify prognostic factors during the observation period. A total of 270 subjects, with a mean age of 74 ± 14 years and a male proportion of 60%, were enrolled in the study. During the 14-day period of hospitalization, 58 participants (22%) had a composite outcome. Patients with low CI (i.e., profiles III and IV) demonstrated an elevated risk of composite outcome after adjusting for confounding variables, as evidenced by the adjusted hazard ratios of 5.85 (95% confidence interval 1.17 to 29.09, p <0.01, vs profile III) and 6.50 (95% confidence interval 1.53 to 27.68, p <0.01, vs profile IV) in comparison with profile I, respectively. In conclusion, the Forrester classification, derived from noninvasive Doppler echocardiography at admission, may predict early deterioration in patients hospitalized with acute HF.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.amjcard.2023.08.119
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37734303; ● Search Scopus @ Elsevier (PMID): 37734303; ● Search Scopus @ Elsevier (DOI): 10.1016/j.amjcard.2023.08.119

(DOI: 10.1016/j.amjcard.2023.08.119, PubMed: 37734303) Sanae Morita, Yukina Hirata, Susumu Nishio, TOMONORI Takahashi, Yoshihito Saijo, Hirotsugu Yamada, Masataka Sata and Kenya Kusunose :
Correlation between energy loss index and B-type natriuretic peptide: a vector flow mapping study,
Journal of Echocardiography, Vol.22, No.1, 25-33, 2023.

(要約): Vector Flow Mapping (VFM) and Energy Loss (EL) evaluation are emerging echocardiographic techniques that offer detailed insights into cardiac function. This study aimed to explore the relationship between EL parameters and B-type natriuretic peptide (BNP) levels, a well-established marker of heart failure severity. Our study prospectively enrolled 62 patients experiencing shortness of breath and suspected heart failure, who underwent echocardiography and had BNP levels measured between January 2018 and August 2020. Patients were stratified based on BNP levels, and their clinical and echocardiographic characteristics were evaluated. Univariate and multivariate regression analyses were performed to assess the correlation between BNP levels and various echocardiographic variables, including VFM parameters. Patients were stratified into two groups based on their BNP levels: BNP < 200 pg/ml (n = 53) and BNP 200 pg/ml (n = 9). Patients with BNP 200 pg/ml presented significantly different clinical and echocardiographic characteristics, such as older age, larger left ventricular mass and volume indices, higher pulmonary artery systolic pressure, higher E/e' ratio, and larger EL parameters. Multivariate regression analysis demonstrated the E/e' ratio and ELA (EL during Atrial contraction phase/A wave ratio as significant determinants of logBNP. Receiver operating characteristic curve analysis showed ELA/A > 36.0 J/m as a significant predictor of high BNP with 89% sensitivity and 85% specificity. ELA/A demonstrated an incremental diagnostic value over elevated left atrial pressure for predicting high BNP (C statistic = 0.98 vs 0.74, P = 0.006). This study provides novel insights into the potential utility of EL parameters as auxiliary indicators of cardiac load, thereby enhancing our understanding of heart failure.
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s12574-023-00623-x
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37707682; ● Summary page in Scopus @ Elsevier: 2-s2.0-85170841573

(DOI: 10.1007/s12574-023-00623-x, PubMed: 37707682, Elsevier: Scopus) Yuichiro Okushi, Yoshihito Saijyo, Hirotsugu Yamada, Hiroaki Toba, Robert Zheng, Hiromitsu Seno, TOMONORI Takahashi, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki, Masataka Sata and Kenya Kusunose :
Effectiveness of surveillance by echocardiography for Cancer therapeutics-related cardiac dysfunction of patients with breast Cancer,
Journal of Cardiology, Vol.82, No.6, 467-472, 2023.

(要約): Cancer therapeutics-related cardiac dysfunction (CTRCD) affect the prognosis of patients with breast cancer. Echocardiographic surveillance of patients treated with anti-human epidermal growth factor receptor type 2 (HER2) antibodies has been recommended, but few reports have provided evidence on patients with breast cancer only. We aimed to evaluate the effectiveness of echocardiographic surveillance for breast cancer patients. We identified 250 patients with breast cancer who were treated with anti-HER2 antibodies from July 2007 to September 2021. We divided 48 patients with echocardiographic surveillance every 3 months into the surveillance group and 202 patients without echocardiographic surveillance into the non-surveillance group. In the surveillance group, patients with a considerable reduction in global longitudinal strain of 15 % were considered for the initiation of cardioprotective drugs. The composite outcome of CTRCD and acute heart failure was the study endpoint. The mean age was 59 ± 12 years. During the follow-up period of 15 months (12-17 months), 12 patients reached the endpoint. The surveillance group had significantly lower incidence of the composite outcome (2.1 % vs. 5.5 %, adjusted odds ratio: 0.28, 95 % confidential intervals: 0.09-0.94; p = 0.039) and higher rates of prescriptions of cardioprotective drugs than the non-surveillance group. The incidence of cardiac complications was significantly lower in the surveillance group than the non-surveillance group, which supports the effectiveness of echocardiographic surveillance in patients with breast cancer.
(徳島大学機関リポジトリ): ● Metadata: 118455
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jjcc.2023.07.002
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37481235; ● Summary page in Scopus @ Elsevier: 2-s2.0-85166962366

(徳島大学機関リポジトリ: 118455, DOI: 10.1016/j.jjcc.2023.07.002, PubMed: 37481235, Elsevier: Scopus) Tomoya Hara, Daiju Fukuda, Byambasuren Ganbaatar, Phuong Tran Pham, Kunduziayi Aini, Arief Rahadian, Kumiko Suto, Shusuke Yagi, Kenya Kusunose, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Olive mill wastewater and hydroxytyrosol inhibits atherogenesis in apolipoprotein E-deficient mice,
Heart and Vessels, Vol.38, No.11, 1386-1394, 2023.

(要約): The Mediterranean diet, which is characterized by high consumption of olive oil, prevents cardiovascular disease. Meanwhile, olive mill wastewater (OMWW), which is obtained as a byproduct during olive oil production, contains various promising bioactive components such as water-soluble polyphenols. Hydroxytyrosol (HT), the major polyphenol in OMWW, has anti-oxidative and anti-inflammatory properties; however, the atheroprotective effects of OMWW and HT remain to be fully understood. Here, we investigated the effect of OMWW and HT on atherogenesis. Male 8-week-old apolipoprotein E-deficient mice were fed a western-type diet supplemented with OMWW (0.30%w/w) or HT (0.02%w/w) for 20 weeks. The control group was fed a non-supplemented diet. OMWW and HT attenuated the development of atherosclerosis in the aortic arch as determined by Sudan IV staining (P < 0.01, respectively) without alteration of body weight, plasma lipid levels, and blood pressure. OMWW and HT also decreased the production of oxidative stress (P < 0.01, respectively) and the expression of NADPH oxidase subunits (e.g., NOX2 and p22phox) and inflammatory molecules (e.g. IL-1β and MCP-1) in the aorta. The results of in vitro experiments demonstrated that HT inhibited the expression of these molecules that were stimulated with LPS in RAW264.7 cells, murine macrophage-like cells. OMWW and HT similarly attenuated atherogenesis. HT is a major component of water-soluble polyphenols in OMWW, and it inhibited inflammatory activation of macrophages. Therefore, our results suggest that the atheroprotective effects of OMWW are at least partially attributable to the anti-inflammatory effects of HT.
(徳島大学機関リポジトリ): ● Metadata: 118456
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s00380-023-02290-5
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37462755; ● Search Scopus @ Elsevier (PMID): 37462755; ● Search Scopus @ Elsevier (DOI): 10.1007/s00380-023-02290-5

(徳島大学機関リポジトリ: 118456, DOI: 10.1007/s00380-023-02290-5, PubMed: 37462755) Shusuke Yagi, Tomoya Hara, Hirotsugu Yamada, Kenya Kusunose, Takayuki Ise and Masataka Sata :
Intimal Sarcoma of the Pulmonary Artery as an Embolic Cause of Sudden Death,
Circulation Journal, Vol.87, No.7, 1036, 2023.

(徳島大学機関リポジトリ): ● Metadata: 118374
(出版サイトへのリンク): ● Publication site (DOI): 10.1253/circj.CJ-23-0029
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37245990; ● Search Scopus @ Elsevier (PMID): 37245990; ● Search Scopus @ Elsevier (DOI): 10.1253/circj.CJ-23-0029

(徳島大学機関リポジトリ: 118374, DOI: 10.1253/circj.CJ-23-0029, PubMed: 37245990) U Munkhjargal, Daiju Fukuda, B Ganbaatar, Kumiko Suto, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Koji Yamaguchi, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
A Selective Mineralocorticoid Receptor Blocker, Esaxerenone, Attenuates Vascular Dysfunction in Diabetic C57BL/6 Mice,
Journal of Atherosclerosis and Thrombosis, Vol.30, No.4, 326-334, 2023.

(要約): Pharmacological blockade of mineralocorticoid receptors (MRs) is a potential therapeutic approach to reduce cardiovascular complications since MRs play a crucial role in cardiovascular regulation. Recent studies suggest that MR antagonists affect several extrarenal tissues, including vessel function. We investigated the effect of a novel nonsteroidal selective MR blocker, esaxerenone, on diabetes-induced vascular dysfunction. Diabetes was induced by a single dose of streptozotocin in 8-week-old male C57BL/6 mice. Esaxerenone (3 mg/kg/day) or a vehicle was administered by gavage to diabetic mice for 3 weeks. Metabolic parameters, plasma aldosterone levels, and parameters related to renal function were measured. Endothelium-dependent or -independent vascular responses of the aortic segments were analyzed with acetylcholine or sodium nitroprusside, respectively. Human umbilical vein endothelial cells (HUVECs) were used for the in vitro study. Induction of diabetes elevated plasma aldosterone level (P<0.05) and impaired endothelium-dependent vascular relaxation (P<0.05). The administration of esaxerenone ameliorated the endothelial dysfunction (P<0.01) without the alteration of metabolic parameters, blood pressure, and renal function. Esaxerenone improved the eNOS phosphorylation in the aorta obtained from diabetic mice (P<0.05) compared with that in the vehicle-treated group. Furthermore, a major MR agonist, aldosterone, decreased eNOS phosphorylation and increased eNOS phosphorylation in HUVECs, which recovered with esaxerenone. Esaxerenone ameliorated the endothelium-dependent vascular relaxation caused by aldosterone in the aortic segments obtained from C57BL/6 mice (P<0.001). Esaxerenone attenuates the development of diabetes-induced endothelial dysfunction in mice. These results suggest that esaxerenone has potential vascular protective effects in individuals with diabetes.
(徳島大学機関リポジトリ): ● Metadata: 118690
(出版サイトへのリンク): ● Publication site (DOI): 10.5551/jat.63382
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35732424; ● Search Scopus @ Elsevier (PMID): 35732424; ● Search Scopus @ Elsevier (DOI): 10.5551/jat.63382

(徳島大学機関リポジトリ: 118690, DOI: 10.5551/jat.63382, PubMed: 35732424) TOMONORI Takahashi, Kenya Kusunose, S Hayashi, Robert Zheng, Natsumi Yamaguchi, Sae Morita, Yukina Hirata, Susumu Nishio, Yoshihito Saijyo, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Isoproterenol loading transesophageal echocardiography in atrial fibrillation,
The International Journal of Cardiovascular Imaging, Vol.39, No.3, 511-518, 2023.

(要約): In patients with sludge or severe spontaneous echo contrast (SEC) in the left atrial appendage (LAA), cases with isoproterenol loading transesophageal echocardiography (ISP-TEE) have been reported to identify the presence of thrombus in the LAA. This study aimed to assess the validity and hemodynamic changes of ISP-TEE in the LAA. We prospectively enrolled patients with atrial fibrillation (AF) who underwent ISP-TEE. The degree of sludge/SEC was categorized as being either absent (grade 0), mild SEC (grade 1), moderate SEC (grade 2), severe SEC or sludge (grade 3). The hemodynamic evaluation was performed by measuring LAA flow velocity, LAA tissue Doppler imaging (LAA-TDI) velocity, and pulmonary vein systolic forward flow velocity (PVS). In total, 35 patients (mean age 71 ± 7 years; 71% male) underwent ISP-TEE. Among 35 patients, 30 patients had grade 3 or 2 SEC, 5 patients had grade 1 SEC. After ISP loading, 23 patients (66% of all patients) showed improved sludge/SEC and one patient was diagnosed with thrombus in the LAA. There were 25 patients with grade 1 SEC, or no SEC (classified as Group1), 10 patients had residual sludge or grade 2 to 3 SEC (classified as Group2) after ISP administration. LAA flow, LAA-TDI, and PVS velocities were significantly higher in group 1 than in group 2 after ISP administration. There was no complication during the examination and after 24 h and 3 months. ISP infusion may be a potential tool to recognize LAA thrombus under the sludge/SEC during TEE in AF.
(キーワード): Humans / Male / Middle Aged / Aged / Female / Atrial Fibrillation / Echocardiography, Transesophageal / Isoproterenol / Sewage / Atrial Appendage / Predictive Value of Tests / Thrombosis
(徳島大学機関リポジトリ): ● Metadata: 118275
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s10554-022-02749-y
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36357528; ● Search Scopus @ Elsevier (PMID): 36357528; ● Search Scopus @ Elsevier (DOI): 10.1007/s10554-022-02749-y

(徳島大学機関リポジトリ: 118275, DOI: 10.1007/s10554-022-02749-y, PubMed: 36357528) Kenya Kusunose, Yuichiro Okushi, Y Okayama, Robert Zheng, M Nakai, Y Sumita, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Benefits of guideline-directed medical therapy to loop diuretics in management of heart failure,
The Journal of Medical Investigation : JMI, Vol.70, No.1.2, 41-53, 2023.

(キーワード): heart failure / angiotensin-converting enzyme inhibitor / angiotensin receptor blocker / β-blockers / mineralocorticoid receptor antagonists
(徳島大学機関リポジトリ): ● Metadata: 118306
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.70.41
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37164742; ● CiNii @ 国立情報学研究所 (CRID): 1390296055446303872; ● Search Scopus @ Elsevier (PMID): 37164742; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.70.41

(徳島大学機関リポジトリ: 118306, DOI: 10.2152/jmi.70.41, PubMed: 37164742, CiNii: 1390296055446303872) Yutaka Kawabata, Tetsuzo Wakatsuki, Koji Yamaguchi, Daiju Fukuda, Hiroyuki Ito, Tomomi Matsuura, Kenya Kusunose, Takayuki Ise, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Y Tsuruo and Masataka Sata :
Association of Microluminal Structures Assessed by Optical Coherence Tomography With Local Inflammation in Adjacent Epicardial Adipose Tissue and Coronary Plaque Characteristics in Fresh Cadavers,
Circulation Journal, Vol.87, No.2, 329-335, 2023.

(要約): Coronary intraplaque microluminal structures (MS) are associated with plaque vulnerability, and the inward progression of vascular inflammation from the adventitia towards the media and intima has also been demonstrated. Therefore, in the present study we investigated the relationships among MS, local inflammation in adjacent epicardial adipose tissue (EAT), and coronary plaque characteristics.Methods and Results: Optical coherence tomography (OCT) revealed MS in the left anterior descending coronary artery in 10 fresh cadaveric hearts. We sampled 30 lesions and subdivided them based on the presence of MS: MS (+) group (n=19) and MS (-) group (n=11). We measured inflammatory molecule levels in the adjacent EAT and percentage lipid volume assessed by integrated backscatter intravascular ultrasound in each lesion. The expression levels of vascular endothelial growth factor B and C-C motif chemokine ligand 2 were significantly higher in the MS (+) group than in the MS (-) group (0.9±0.7 vs. 0.2±0.2 arbitrary units (AU), P=0.04 and 1.5±0.5 vs. 0.6±0.7 AU, P=0.02, respectively). Percentage lipid volume was significantly higher in the MS (+) group than in the MS (-) group (38.7±16.5 vs. 23.7±10.9%, P=0.03). Intraplaque MS observed on OCT were associated with lipid-rich plaques and local inflammation in the adjacent EAT. Collectively, these results suggest that local inflammation in the EAT is associated with coronary plaque vulnerability via MS.
(徳島大学機関リポジトリ): ● Metadata: 117602
(出版サイトへのリンク): ● Publication site (DOI): 10.1253/circj.CJ-22-0299
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36244741; ● Search Scopus @ Elsevier (PMID): 36244741; ● Search Scopus @ Elsevier (DOI): 10.1253/circj.CJ-22-0299

(徳島大学機関リポジトリ: 117602, DOI: 10.1253/circj.CJ-22-0299, PubMed: 36244741) Tomonori Takahashi, Kenya Kusunose, Robert Zheng, Natsumi Yamaguchi, Yukina Hirata, Susumu Nishio, Yoshihito Saijyo, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Association between cardiovascular risk factors and left ventricular strain distribution in patients without previous cardiovascular disease,
Journal of Echocardiography, Vol.20, No.4, 208-215, 2022.

(要約): Some cardiovascular (CV) risk factors, such as hypertension and diabetes mellitus, have been reported to reduce left ventricular (LV) longitudinal strain (LS) even in patients with preserved LV ejection fraction. We hypothesized that multiple CV risk factors might cause changes in myocardial strain. Our study aimed to assess the association between multiple CV risk factors and strain in patients without previous CV disease (CVD). We retrospectively evaluated 137 patients without CVD, who underwent echocardiography at our institution between May 2017 and February 2020. They were divided into four groups based on the number of risk factors (group 0: no risk factor, group 1: one risk factor, group 2: two risk factors, and groups 3: three or four risk factors). Risk factors were hypertension, dyslipidemia, diabetes mellitus, and chronic kidney disease. Absolute values of global LS (GLS) and relative apical LS ratio (RALSR) defined using the equation: average apical LS/(average basal LS + average mid LS) and was used as a marker of strain distribution. Out of 137 patients, group 0 had 35 patients, group 1 had 35 patients, group 2 had 32 patients, and group 3 had 35 patients. GLS was 22.4 ± 2.0%, 21.7 ± 2.1%, 21.3 ± 1.8%, 20.7 ± 2.2%, and RALSR was 0.64 ± 0.06, 0.66 ± 0.06, 0.68 ± 0.08, 0.69 ± 0.07 in groups 0-3, respectively. The one-way ANOVA detected significant differences between groups in GLS (p = 0.005) and RALSR (p = 0.037), respectively. Group 3 had a significantly lower GLS and higher RALSR than group 0 (p < 0.05). In patients without previous CVD, LS decreased especially from the basal segment as the number of cardiovascular risks increased. The segmental LS may be markers of occult LV dysfunction in patients with CV risk factors.
(キーワード): Humans / Cardiovascular Diseases / Retrospective Studies / Risk Factors / Stroke Volume / Ventricular Function, Left / Ventricular Dysfunction, Left / Heart Disease Risk Factors / Hypertension
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s12574-022-00576-7
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35562627; ● Search Scopus @ Elsevier (PMID): 35562627; ● Search Scopus @ Elsevier (DOI): 10.1007/s12574-022-00576-7

(DOI: 10.1007/s12574-022-00576-7, PubMed: 35562627) O Bavuu, Daiju Fukuda, B Ganbaatar, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Koji Yamaguchi, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Esaxerenone, a selective mineralocorticoid receptor blocker, improves insulin sensitivity in mice consuming high-fat diet.,
European Journal of Pharmacology, 175190, 2022.

(要約): Esaxerenone is a novel, non-steroidal selective mineralocorticoid receptor (Csige et al.) blocker. MR activation plays a crucial role in the development of cardiovascular and metabolic diseases. In this study, we investigated the effects of esaxerenone on various metabolic parameters in mice. Esaxerenone (3 mg/kg/day) was orally administered to high-fat diet (HFD)-fed male C57BL/6 mice. Mice fed a normal diet (ND) served as controls. Glucose and insulin tolerance, plasma lipid levels, and transaminase levels were assessed as metabolic parameters. Macrophage accumulation in the adipose tissue was evaluated using histological analysis. 3T3-L1 adipocytes, HepG2 cells, and C2C12 myotubes were used for in vitro experiments. Gene expression and insulin signaling were examined using quantitative RT-PCR and western blotting, respectively. HFD successfully induced insulin resistance compared with that in ND. Esaxerenone ameliorated insulin resistance (P < 0.05) without altering other metabolic parameters, such as the lipid profile. Esaxerenone administration tended to decrease plasma transaminase levels compared with those in the non-treated group. In the adipose tissue, esaxerenone decreased macrophage accumulation (P < 0.05) and increased the expression levels of adiponectin and PPARγ. Aldosterone significantly decreased the expression levels of PPARγ and adiponectin in 3T3-L1 adipocytes. Furthermore, aldosterone attenuated insulin-induced Akt phosphorylation in 3T3-L1 adipocytes, HepG2 cells, and C2C12 myotubes in a dose-dependent manner (P < 0.01). These effects were ameliorated by pretreatment with esaxerenone. Esaxerenone ameliorated insulin resistance in HFD-fed mice. Reduction of inflammation and improvement in insulin signaling may underlie the beneficial effects of esaxerenone.
(徳島大学機関リポジトリ): ● Metadata: 117375
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.ejphar.2022.175190
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35961594; ● Search Scopus @ Elsevier (PMID): 35961594; ● Search Scopus @ Elsevier (DOI): 10.1016/j.ejphar.2022.175190

(徳島大学機関リポジトリ: 117375, DOI: 10.1016/j.ejphar.2022.175190, PubMed: 35961594) Kenya Kusunose, Hirotsugu Yamada, Y Saijo, Susumu Nishio, Yukina Hirata, Takayuki Ise, Koji Yamaguchi, Daiju Fukuda, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Clinical course and decision-making in heart failure by preload stress echocardiography: a preliminary study,
ESC Heart Failure, Vol.9, No.6, 4020-4029, 2022.

(要約): Abnormal left ventricular diastolic response to preload stress can be an early marker of heart failure (HF). The aim of this study was to assess clinical course in patients with HF with preserved ejection fraction (HFpEF) who underwent preload stress echocardiography. In the subgroup analysis, we assessed the prognosis of patients with unstable signs during preload stress classified by treatment strategies. We prospectively conducted preload stress echocardiographic studies between January 2006 and December 2013 in 211 patients with HFpEF. Fifty-eight patients had abnormal diastolic reserve during preload stress (unstable impaired relaxation: unstable IR). Of 58 patients with unstable IR, 19 patients were assigned to additional therapy by increased or additional therapy and 39 patients were assigned to standard therapy. Composite outcomes were prespecified as the primary endpoint of death and hospitalization for deteriorating HF. During a median period of 6.9 years, 19 patients (33%) reached the composite outcome. Unstable group with standard therapy had significantly shorter event-free survival than stable group. Patients with uptitration of therapy had longer event-free survival than those with standard therapy group after adjustment of laboratory data (hazard ratio, 0.20, 95% confidence interval, 0.05-0.90; P = 0.036); the 10 year event-free survival in patients with and without uptitration of therapy was 93% and 51%, respectively (P = 0.023). Patients with unstable sign had significantly shorter event-free survival than patients with stable sign. After additional therapy, the prognosis of patients with unstable signs improved. This technique may impact decision-making for improving their prognosis.
(徳島大学機関リポジトリ): ● Metadata: 118008
(出版サイトへのリンク): ● Publication site (DOI): 10.1002/ehf2.14127
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36017722; ● Search Scopus @ Elsevier (PMID): 36017722; ● Search Scopus @ Elsevier (DOI): 10.1002/ehf2.14127

(徳島大学機関リポジトリ: 118008, DOI: 10.1002/ehf2.14127, PubMed: 36017722) Koji Yamaguchi, Tetsuzo Wakatsuki, Tomomi Matsuura, Kazuhisa Matsumoto, Yutaka Kawabata, Muneyuki Kadota, Kenya Kusunose, Takayuki Ise, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Drug-coated balloon angioplasty for severe pulmonary vein stenosis resulting from cryoballoon ablation for atrial fibrillation,
Journal of Cardiology Cases, Vol.26, 35-38, 2022.

(徳島大学機関リポジトリ): ● Metadata: 117234
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jccase.2022.02.009
(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-85127324683

(徳島大学機関リポジトリ: 117234, DOI: 10.1016/j.jccase.2022.02.009, Elsevier: Scopus) Y Okushi, Kenya Kusunose, M Nakai, Y Sumita, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Comparison of Direct Oral Anticoagulants for Acute Hospital Mortality in Venous Thromboembolism,
American Journal of Cardiovascular Drugs, Vol.22, No.4, 407-416, 2022.

(要約): The choice of direct oral anticoagulants (DOACs) for venous thromboembolism (VTE) is at the physician's discretion; however, it is useful to know the differences in the clinical data of DOACs to help physicians choose. We aimed to compare the mortality associated with the use of rivaroxaban, edoxaban, and apixaban in clinical practice. We identified 38,245 patients with first hospitalization for VTE from the Diagnosis Procedure Combination database in the Japanese Registry of All Cardiac and Vascular Datasets (JROAD-DPC). We classified patients into three groups by DOAC (rivaroxaban and edoxaban group, rivaroxaban and apixaban group, and edoxaban and apixaban group) and compared the in-hospital mortality and bleeding risk by propensity score (PS) matching in each group. After PS matching, patients with rivaroxaban use had significantly lower total in-hospital mortality (1.2% vs. 2.1%; odds ratio [OR] 0.55, p = 0.012) and in-hospital mortality within 21 days (0.4% vs. 1.0%; OR 0.41, p = 0.020) and 28 days (0.7% vs. 1.3%; OR 0.53, p = 0.042) than patients with apixaban use. In the subanalysis, significant differences were only observed in patients younger than 80 years of age, patients with pulmonary embolism, and patients without heart failure. There was no significant difference in in-hospital mortality in the other groups and in the rate of bleeding events among the three groups. On PS-matched analysis, there was a difference in in-hospital mortality, especially in the rivaroxaban and apixaban group. Identifying the clinical characteristics of patients associated with each DOAC, as well as prognosis, will be useful in determining treatment strategies for VTE.
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s40256-021-00514-5
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34927214; ● Search Scopus @ Elsevier (PMID): 34927214; ● Search Scopus @ Elsevier (DOI): 10.1007/s40256-021-00514-5

(DOI: 10.1007/s40256-021-00514-5, PubMed: 34927214) Kazuhisa Matsumoto, Takeshi Tobiume, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Tetsuzo Wakatsuki, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Evaluation of the input site and characteristics of the antegrade fast pathway based on three-dimensional bi-atrial stimulus-ventricle mapping,
Journal of Interventional Cardiac Electrophysiology, Vol.63, No.2, 417-424, 2022.

(要約): Previous studies examined the right atrial (RA) input site of the antegrade fast pathway (AFp) (AFpI). However, the left atrial (LA) input to the atrioventricular (AV) node has not been extensively evaluated. In this study, we created three-dimensional (3-D) bi-atrial stimulus-ventricle (St-V) maps and analyzed the input site and characteristics of the AFp in both the RA and LA. Forty-four patients diagnosed with atrial fibrillation or WPW syndrome were included in this study. Three-dimensional bi-atrial St-V mapping was performed using an electroanatomical mapping system. Sites exhibiting the minimal St-V interval (MinSt-V) were defined as AFpIs and were classified into seven segments, four in the RA (F, S, M, and I) and three in the LA (M1, M2, and M3). By combining the MinSt-V in the RA and LA, the AFpIs were classified into three types: RA, LA, and bi-atrial (BA) types. The clinical and electrophysiological characteristics were compared. AFpIs were most frequently observed at site S in the RA (34%) and M2 in the LA (50%), and the BA type was the most common (57%). AFpIs in the LA were recognized in 75% of the patients. There were no clinical or electrophysiological indicators for predicting AFpI sites. Three-dimensional bi-atrial St-V maps could classify AFpIs in both the RA and LA. AFpIs in the LA were frequently recognized. There were no significant clinical or electrophysiological indicators for predicting AFpI sites, and 3-D bi-atrial St-V mapping was the only method to reveal the precise AFp input site.
(徳島大学機関リポジトリ): ● Metadata: 116382
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s10840-021-01026-7
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34231099; ● Search Scopus @ Elsevier (PMID): 34231099; ● Search Scopus @ Elsevier (DOI): 10.1007/s10840-021-01026-7

(徳島大学機関リポジトリ: 116382, DOI: 10.1007/s10840-021-01026-7, PubMed: 34231099) Kenya Kusunose, Robert Zheng, Hirotsugu Yamada and Masataka Sata :
How to standardize the measurement of left ventricular ejection fraction,
Journal of Medical Ultrasonics, Vol.49, No.1, 35-43, 2022.

(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s10396-021-01116-z
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34322777; ● Summary page in Scopus @ Elsevier: 2-s2.0-85111531757

(DOI: 10.1007/s10396-021-01116-z, PubMed: 34322777, Elsevier: Scopus) Shusuke Yagi, Daiju Fukuda, Takayuki Ise, Koji Yamaguchi, Kenya Kusunose, Muneyuki Kadota, Yutaka Kawabata, Tomomi Matsuura, Tomohiro Soga, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Shinji Kawahito and Masataka Sata :
Clinical clerkship students' preferences and satisfaction regarding online lectures during the COVID-19 pandemic,
BMC Medical Education, Vol.22, No.1, 43, 2022.

(要約): The COVID-19 pandemic has caused an unprecedented disruption in medical education. Students and lecturers had to adapt to online education. The current study aimed to investigate the level of satisfaction and future preference for online lectures among clinical clerkship students and elucidated the factors that affect these outcomes. We selected a sample of 114 medical students undergoing clinical clerkship during the COVID-19 pandemic. We conducted onsite lectures before the pandemic and online lectures after the outbreak. A survey was conducted, and the sample included students and 17 lecturers. The average scores of total satisfaction and future preference related to online lectures were computed. Students' scores on total satisfaction with online lectures and their future preference were higher than those for onsite lectures. Scores on the ease of debating dimension were low and those on accessibility of lectures in online lectures were higher than those in onsite lectures. There was no difference between the two groups in the scores on the comprehensibility and ease of asking questions dimensions. Results of the multiple regression analysis revealed that accessibility determined total satisfaction, and future preference was determined by comprehensibility as well as accessibility. Contrary to students' future preferences, lecturers favored onsite lectures to online ones. Online lectures are an acceptable mode of teaching during the COVID-19 pandemic for students undergoing clinical clerkship. Online lectures are expected to become more pervasive to avoid the spread of COVID-19.
(キーワード): COVID-19 / Clinical Clerkship / Humans / Pandemics / Personal Satisfaction / SARS-CoV-2 / Students, Medical
(徳島大学機関リポジトリ): ● Metadata: 116989
(出版サイトへのリンク): ● Publication site (DOI): 10.1186/s12909-021-03096-7
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35042505; ● Summary page in Scopus @ Elsevier: 2-s2.0-85123015852

(徳島大学機関リポジトリ: 116989, DOI: 10.1186/s12909-021-03096-7, PubMed: 35042505, Elsevier: Scopus) Nao Ishii, Kenya Kusunose, A Shono, K Matsumoto, Susumu Nishio, Natsumi Yamaguchi, Yukina Hirata, Tomomi Matsuura, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Effects of Radiofrequency Catheter Ablation on Cardiac Reserve Using Preload Stress Echocardiography in Paroxysmal and Persistent Atrial Fibrillation,
The American Journal of Cardiology, Vol.168, 71-77, 2022.

(要約): The effects of catheter ablation on exercise tolerance and quality of life in patients with atrial fibrillation (AF) have been reported. We assessed cardiac function in more detail using the leg positive pressure (LPP) technique and found that contractile reserve is particularly important in relation to exercise tolerance and prognosis. In this study, we used the LPP technique to examine changes in contractile reserve immediately after ablation and 6 months later. We prospectively enrolled patients who underwent catheter ablation for AF at 2 institutes. We performed LPP stress echocardiography 2 to 3 days after (FU-1) and 6 months after (FU-2) ablation to examine changes in cardiac function indexes. The primary end point was improvement in contractile reserve. Ultimately, 109 patients (mean age 67.4 ± 9.6 years; 70% men) underwent 2 sessions of LPP stress echocardiography. The median CHADS-VAS score was 2 (interquartile range 13). From FU-1 to FU-2, the change in the stroke volume index after the LPP maneuver increased in patients with paroxysmal and persistent AF with low CHADS-VAS scores (both p <0.05). Regardless of AF subtype, contractile reserve at FU-2 improved in patients with low CHADS-VAS scores compared with that at FU-1. In contrast, patients with high CHADS-VAS scores had no change. In conclusion, patients with AF with a low CHADS-VAS score had improved contractile reserve after ablation, whereas patients with high scores did not show any improvement. Aggressive interventions in patients with high scores may lead to better management after catheter ablation.
(キーワード): Aged / Atrial Fibrillation / Catheter Ablation / Echocardiography, Stress / Female / Humans / Male / Middle Aged / Predictive Value of Tests / Quality of Life / Risk Assessment / Risk Factors / Treatment Outcome
(徳島大学機関リポジトリ): ● Metadata: 116987
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.amjcard.2021.12.026
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35063270; ● Search Scopus @ Elsevier (PMID): 35063270; ● Search Scopus @ Elsevier (DOI): 10.1016/j.amjcard.2021.12.026

(徳島大学機関リポジトリ: 116987, DOI: 10.1016/j.amjcard.2021.12.026, PubMed: 35063270) Kenya Kusunose, H Yoshida, A Tanaka, H Teragawa, Y Akasaki, Y Fukumoto, K Eguchi, H Kamiya, K Kario, Hirotsugu Yamada, Masataka Sata, K Node and Munehide Matsuhisa :
Effect of febuxostat on left ventricular diastolic function in patients with asymptomatic hyperuricemia: a sub analysis of the PRIZE Study,
Hypertension Research, Vol.45, No.1, 106-115, 2022.

(徳島大学機関リポジトリ): ● Metadata: 116992
(出版サイトへのリンク): ● Publication site (DOI): 10.1038/s41440-021-00752-9
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34657137; ● Search Scopus @ Elsevier (PMID): 34657137; ● Search Scopus @ Elsevier (DOI): 10.1038/s41440-021-00752-9

(徳島大学機関リポジトリ: 116992, DOI: 10.1038/s41440-021-00752-9, PubMed: 34657137) Kumiko Suto, Daiju Fukuda, Masakazu Shinohara, Byambasuren Ganbaatar, Shusuke Yagi, Kenya Kusunose, Hirotsugu Yamada, Takeshi Soeki, Ken-Ichi Hirata and Masataka Sata :
Pemafibrate, A Novel Selective Peroxisome Proliferator-Activated Receptor α Modulator, Reduces Plasma Eicosanoid Levels and Ameliorates Endothelial Dysfunction in Diabetic Mice.,
Journal of Atherosclerosis and Thrombosis, Vol.28, No.12, 1349-1360, 2021.

(要約): Various pathological processes related to diabetes cause endothelial dysfunction. Eicosanoids derived from arachidonic acid (AA) have roles in vascular regulation. Fibrates have recently been shown to attenuate vascular complications in diabetics. Here we examined the effects of pemafibrate, a selective peroxisome proliferator-activated receptor α modulator, on plasma eicosanoid levels and endothelial function in diabetic mice. Diabetes was induced in 7-week-old male wild-type mice by a single injection of streptozotocin (150 mg/kg). Pemafibrate (0.3 mg/kg/day) was administered orally for 3 weeks. Untreated mice received vehicle. Circulating levels of eicosanoids and free fatty acids were measured using both gas and liquid chromatography-mass spectrometry. Endothelium-dependent and endothelium-independent vascular responses to acetylcholine and sodium nitroprusside, respectively, were analyzed. Pemafibrate reduced both triglyceride and non-high-density lipoprotein -cholesterol levels (P<0.01), without affecting body weight. It also decreased circulating levels of AA (P<0.001), thromboxane B (P<0.001), prostaglandin E, leukotriene B (P<0.05), and 5-hydroxyeicosatetraenoic acid (P<0.001), all of which were elevated by the induction of diabetes. In contrast, the plasma levels of 15-deoxy-Δ-prostaglandin J, which declined following diabetes induction, remained unaffected by pemafibrate treatment. In diabetic mice, pemafibrate decreased palmitic acid (PA) and stearic acid concentrations (P<0.05). Diabetes induction impaired endothelial function, whereas pemafibrate ameliorated it (P<0.001). The results of ex vivo experiments indicated that eicosanoids or PA impaired endothelial function. Pemafibrate diminished the levels of vasoconstrictive eicosanoids and free fatty acids accompanied by a reduction of triglyceride. These effects may be associated with the improvement of endothelial function by pemafibrate in diabetic mice.
(徳島大学機関リポジトリ): ● Metadata: 116054
(出版サイトへのリンク): ● Publication site (DOI): 10.5551/jat.61101
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33775978; ● Search Scopus @ Elsevier (PMID): 33775978; ● Search Scopus @ Elsevier (DOI): 10.5551/jat.61101

(徳島大学機関リポジトリ: 116054, DOI: 10.5551/jat.61101, PubMed: 33775978) Kenya Kusunose, Miharu Arase, Robert Zheng, Yukina Hirata, Susumu Nishio, Takayuki Ise, Koji Yamaguchi, Daiju Fukuda, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Clinical Utility of Overlap Time for Incomplete Relaxation to Predict Cardiac Events in Heart Failure: Incomplete relaxation in heart failure,
Journal of Cardiac Failure, Vol.27, No.11, 1222-1230, 2021.

(要約): The overlap time of transmitral flow can be a novel marker of subclinical left ventricular (LV) dysfunction for predicting adverse events in heart failure (HF). We aimed to 1) investigate the role of overlap time of E-A wave in association with clinical parameters, and 2) evaluate whether the overlap time could add prognostic information with respect to other conventional clinical prognosticators in HF. We prospectively evaluated 153 patients hospitalized with HF (mean age 68±15 years; 63% male). The primary endpoint was readmission following HF and cardiac death. During a median period of 25 months, 43 patients were either readmitted or died. Overlap time appeared to be associated with worse outcomes. After adjustment for readmission score and ratio of diastolic filling period and cardiac cycle length in a Cox proportional-hazards model, overlap time was associated with event free survival, independent of elevated left atrial pressure (LAP) based on guidelines. When overlap time was added to the model based on clinical variables and elevated LAP, the C-statistic significantly improves from 0.70 (95% CI: 0.63-0.77) to 0.77 (95% CI: 0.69-0.83, compared P=0.035). This preliminary study suggested that prolonged overlap time may have potential for predicting readmission and cardiac mortality risk assessment in HF.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.cardfail.2021.05.018
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34129950; ● Search Scopus @ Elsevier (PMID): 34129950; ● Search Scopus @ Elsevier (DOI): 10.1016/j.cardfail.2021.05.018

(DOI: 10.1016/j.cardfail.2021.05.018, PubMed: 34129950) Robert Zheng, Kenya Kusunose, Y Okushi, Y Okayama, M Nakai, Y Sumita, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Impact of cancer on short-term in-hospital mortality after primary acute myocardial infarction,
Open Heart, Vol.8, No.2, e00186, 2021.

(徳島大学機関リポジトリ): ● Metadata: 116972
(出版サイトへのリンク): ● Publication site (DOI): 10.1136/openhrt-2021-001860
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34810277; ● Summary page in Scopus @ Elsevier: 2-s2.0-85120377378

(徳島大学機関リポジトリ: 116972, DOI: 10.1136/openhrt-2021-001860, PubMed: 34810277, Elsevier: Scopus) Kenya Kusunose, Hironori Takahashi, Susumu Nishio, Yukina Hirata, Robert Zheng, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Kenji Shimada, Yasuhisa Kanematsu, Yasushi Takagi and Masataka Sata :
Predictive value of left atrial function for latent paroxysmal atrial fibrillation as the cause of embolic stroke of undetermined source,
Journal of Cardiology, Vol.78, No.5, 355-361, 2021.

(要約): In patients with embolic stroke of undetermined source (ESUS), paroxysmal atrial fibrillation (AF) is often diagnosed, however, the risk of paroxysmal AF in ESUS has not been well described. Several studies have suggested a linkage between left atrial (LA) functional parameters and risk of AF in stroke patients. The aim of this study was to assess the role of LA functional parameters as predictors of latent paroxysmal AF in ESUS on admission. Between January 2015 and December 2019, consecutive stroke patients with suspected ESUS at admission were prospectively included in this study. They were under hospital electrocardiographic monitoring for detection of new-onset AF. Various echocardiographic parameters including left atrial strain were assessed for association with new-onset AF. We gathered 1082 consecutive patients with ischemic stroke. After exclusions, 121 patients with suspected ESUS at admission formed the study cohort. New-onset AF was detected in 46 (38%) patients during hospital electrocardiographic monitoring (median follow-up: 18 days). LA pump and reservoir strains were significantly and independently associated with new-onset AF. Receiver operating characteristic analysis for the association with new-onset AF showed that the areas under the curve (AUCs) of clinical parameters plus one of each strain (LA pump strain: AUC: 0.86±0.04 and LA reservoir strain: AUC: 0.76±0.05) models were significantly better than plus LA volume index (AUC: 0.68±0.04, compared p-values <0.05). LA strain was significantly associated with new development of AF. Patients with impaired LA function at admission should be carefully monitored to find AF.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jjcc.2021.05.005
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34119401; ● Search Scopus @ Elsevier (PMID): 34119401; ● Search Scopus @ Elsevier (DOI): 10.1016/j.jjcc.2021.05.005

(DOI: 10.1016/j.jjcc.2021.05.005, PubMed: 34119401) Kenya Kusunose, Yuichiro Okushi, Yoshihiro Okayama, Robert Zheng, Michikazu Nakai, Yoko Sumita, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Use of Echocardiography and Heart Failure In-Hospital Mortality from Registry Data in Japan.,
Journal of Cardiovascular Development and Disease, Vol.8, No.10, 124, 2021.

(要約): Echocardiography requires a high degree of skill on the part of the examiner, and the skill may be more improved in larger volume centers. This study investigated trends and outcomes associated with the use and volume of echocardiographic exams from a real-world registry database of heart failure (HF) hospitalizations. This study was based on the Diagnosis Procedure Combination database in the Japanese Registry of All Cardiac and Vascular Datasets (JROAD-DPC). A first analysis was performed to assess the trend of echocardiographic examinations between 2012 and 2016. A secondary analysis was performed to assess whether echocardiographic use was associated with in-hospital mortality in 2015. During this period, the use of echocardiography grew at an average annual rate of 6%. Patients with echocardiography had declining rates of hospital mortality, and these trends were associated with high hospitalization costs. In the 2015 sample, a total of 52,832 echocardiograms were examined, corresponding to 65.6% of all HF hospital admissions for that year. We found that the use and volume of echocardiography exams were associated with significantly lower odds of all-cause hospital mortality in heart failure (adjusted odds ratio (OR): 0.48 for use of echocardiography and 0.78 for the third tertile; both < 0.001). The use of echocardiography was associated with decreased odds of hospital mortality in HF. The volumes of echocardiographic examinations were also associated with hospital mortality.
(徳島大学機関リポジトリ): ● Metadata: 117323
(出版サイトへのリンク): ● Publication site (DOI): 10.3390/jcdd8100124
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34677193; ● Summary page in Scopus @ Elsevier: 2-s2.0-85116636823

(徳島大学機関リポジトリ: 117323, DOI: 10.3390/jcdd8100124, PubMed: 34677193, Elsevier: Scopus) Shusuke Yagi, T Takahashi, K Murakami, M Azuma, M Sugano, R Miyamoto, M Niki, Hirotsugu Yamada, Yutaka Kawabata, Tani Akihiro, Daiju Fukuda, Muneyuki Kadota, Takayuki Ise, Kenya Kusunose, Takeshi Tobiume, Tomomi Matsuura, Koji Yamaguchi, Takeshi Soeki, Tetsuzo Wakatsuki, H Hata and Masataka Sata :
Infective Endocarditis from Furuncle with Meningitis Complication Caused by Methicillin-resistant Staphylococcus aureus,
Internal Medicine, Vol.60, No.20, 3251-3255, 2021.

(徳島大学機関リポジトリ): ● Metadata: 118014
(出版サイトへのリンク): ● Publication site (DOI): 10.2169/internalmedicine.6902-20
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33867390; ● Search Scopus @ Elsevier (PMID): 33867390; ● Search Scopus @ Elsevier (DOI): 10.2169/internalmedicine.6902-20

(徳島大学機関リポジトリ: 118014, DOI: 10.2169/internalmedicine.6902-20, PubMed: 33867390) Kenya Kusunose, T Imai, A Tanaka, K Dohi, K Shiina, T Yamada, K Kida, K Eguchi, H Teragawa, Y Takeishi, N Ohte, Hirotsugu Yamada, Masataka Sata and K Node :
Effects of canagliflozin on NT-proBNP stratified by left ventricular diastolic function in patients with type 2 diabetes and chronic heart failure: a sub analysis of the CANDLE trial,
Cardiovascular Diabetology, Vol.20, No.1, 186, 2021.

(要約): Identification of the effective subtypes of treatment for heart failure (HF) is an essential topic for optimizing treatment of the disorder. We hypothesized that the beneficial effect of SGLT2 inhibitors (SGLT2i) on the levels of N-terminal pro-brain natriuretic peptide (NT-proBNP) might depend on baseline diastolic function. To elucidate the effects of SGLT2i in type 2 diabetes mellitus (T2DM) and chronic HF we investigated, as a post-hoc sub-study of the CANDLE trial, the effects of canagliflozin on NT-proBNP levels from baseline to 24 weeks, with the data stratified by left ventricular (LV) diastolic function at baseline. Patients (n = 233) in the CANDLE trial were assigned randomly to either an add-on canagliflozin (n = 113) or glimepiride treatment groups (n = 120). The primary endpoint was a comparison between the two groups of the changes from baseline to 24 weeks in NT-pro BNP levels, stratified according to baseline ventricular diastolic function. The change in the geometric mean of NT-proBNP level from baseline to 24 weeks was 0.98 (95% CI 0.89-1.08) in the canagliflozin group and 1.07 (95% CI 0.97-1.18) in the glimepiride group. The ratio of change with canagliflozin/glimepiride was 0.93 (95% CI 0.82-1.05). Responder analyses were used to investigate the response of an improvement in NT-proBNP levels. Although the subgroup analyses for septal annular velocity (SEP-e') showed no marked heterogeneity in treatment effect, the subgroup with an SEP-e' < 4.7 cm/s indicated there was an association with lower NT-proBNP levels in the canagliflozin group compared with that in the glimepiride group (ratio of change with canagliflozin/glimepiride (0.83, 95% CI 0.66-1.04). In the subgroup with a lower LV diastolic function, canagliflozin showed a trend of reduced NT-pro BNP levels compared to that observed with glimepiride. This study suggests that the beneficial effects of canagliflozin treatment may be different in subgroups classified by the severity of LV diastolic dysfunction.
(徳島大学機関リポジトリ): ● Metadata: 116720
(出版サイトへのリンク): ● Publication site (DOI): 10.1186/s12933-021-01380-w
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34521417; ● Summary page in Scopus @ Elsevier: 2-s2.0-85115075981

(徳島大学機関リポジトリ: 116720, DOI: 10.1186/s12933-021-01380-w, PubMed: 34521417, Elsevier: Scopus) Yuta Torii, Kenya Kusunose, Yukina Hirata, Susumu Nishio, Takayuki Ise, Koji Yamaguchi, Daiju Fukuda, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Left Atrial Strain Associated with Functional Recovery in Patients Receiving Optimal Treatment for Heart Failure,
Journal of the American Society of Echocardiography, Vol.34, No.9, 966-975, 2021.

(要約): Heart failure with recovered ejection fraction (HFrecEF) has been reported in several previous studies to have a better prognosis than heart failure with reduced ejection fraction (HFrEF). However, the factors associated with HFrecEF have not been identified. The aim of this study was to test the hypothesis that left atrial (LA) strain could help identify patients with recovered ejection fraction (EF) among those with heart failure (HF) with low EF on admission. One hundred consecutive patients hospitalized for the first time for new-onset HF were enrolled. Patients were clinically diagnosed with HFrEF on admission (left ventricular EF < 40%) and received optimal treatment for HF. Twenty-eight patients improved to HFrecEF during 6 months of follow-up. Regarding clinical background, there were significantly more women and a lower rate of atrial fibrillation in the HFrecEF group than in the HFrEF group. In a multivariate logistic regression analysis, LA strain was an independent predictor of HFrecEF, even after adjustment for gender and left ventricular EF (odds ratio: 4.06; 95% CI: 2.04-8.07; P < .001). A cutoff value of 10.8% for LA strain showed high sensitivity (96%) and specificity (82%) in identifying HFrecEF in patients with HF presenting with low EF on admission. During a follow-up period of 24 ± 13 months, 31 patients (31%) had cardiovascular death or readmission for HF. Patients with reduced LA strain (<10.8%) had significantly shorter event-free survival than those with preserved LA strain (P = .02). LA strain is a useful indicator for predicting HFrecEF and should be considered as a routine measurement in patients with HFrEF on admission.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.echo.2021.03.016
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33852960; ● Search Scopus @ Elsevier (PMID): 33852960; ● Search Scopus @ Elsevier (DOI): 10.1016/j.echo.2021.03.016

(DOI: 10.1016/j.echo.2021.03.016, PubMed: 33852960) Tomomi Matsuura, Takeshi Soeki, Daiju Fukuda, Etsuko Uematsu, Takeshi Tobiume, Tomoya Hara, Kenya Kusunose, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Hirotsugu Yamada, Tetsuzo Wakatsuki and Masataka Sata :
Activated Factor X Signaling Pathway via Protease-Activated Receptor 2 Is a Novel Therapeutic Target for Preventing Atrial Fibrillation,
Circulation Journal, Vol.85, No.8, 1383-1391, 2021.

(要約): Activated factor X (FXa), which contributes to chronic inflammation via protease-activated receptor 2 (PAR2), might play an important role in atrial fibrillation (AF) arrhythmogenesis. This study aimed to assess whether PAR2 signaling contributes to AF arrhythmogenesis and whether rivaroxaban ameliorates atrial inflammation and prevents AF.Methods and Results:In Study 1, PAR2 deficient (PAR2-/-) and wild-type mice were infused with angiotensin II (Ang II) or a vehicle via an osmotic minipump for 2 weeks. In Study 2, spontaneously hypertensive rats (SHRs) were treated with rivaroxaban, warfarin, or vehicle for 2 weeks after 8 h of right atrial rapid pacing. The AF inducibility and atrial remodeling in both studies were examined. Ang II-treated PAR2-/- mice had a lower incidence of AF and less mRNA expression of collagen1 and collagen3 in the atrium compared to wild-type mice treated with Ang II. Rivaroxaban significantly reduced AF inducibility compared with warfarin or vehicle. In SHRs treated with a vehicle, rapid atrial pacing promoted gene expression of inflammatory and fibrosis-related biomarkers in the atrium. Rivaroxaban, but not warfarin, significantly reduced expression levels of these genes. The FXa-PAR2 signaling pathway might contribute to AF arrhythmogenesis associated with atrial inflammation. A direct FXa inhibitor, rivaroxaban, could prevent atrial inflammation and reduce AF inducibility, probably by inhibiting the pro-inflammatory activation.
(徳島大学機関リポジトリ): ● Metadata: 116065
(出版サイトへのリンク): ● Publication site (DOI): 10.1253/circj.CJ-20-1006
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33746155; ● Summary page in Scopus @ Elsevier: 2-s2.0-85111576585

(徳島大学機関リポジトリ: 116065, DOI: 10.1253/circj.CJ-20-1006, PubMed: 33746155, Elsevier: Scopus) Pham Tran Phuong, Daiju Fukuda, Sachiko Nishimoto, JR Kim-Kaneyama, XF Lei, Yutaka Takahashi, Tomohito Sato, Kimie Tanaka, Kumiko Suto, Yutaka Kawabata, Koji Yamaguchi, Shusuke Yagi, Kenya Kusunose, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Kenji Shimada, Yasuhisa Kanematsu, Yasushi Takagi, Michio Shimabukuro, Mitsutoshi Setou, Glen N Barber and Masataka Sata :
STING, a cytosolic DNA sensor, plays a critical role in atherogenesis: a link between innate immunity and chronic inflammation caused by lifestyle-related diseases,
European Heart Journal, Vol.42, No.42, 4336-4348, 2021.

(要約): Lifestyle-related diseases promote atherosclerosis, a chronic inflammatory disease; however, the molecular mechanism remains largely unknown. Endogenous DNA fragments released under over-nutrient condition provoke sterile inflammation through the recognition by DNA sensors. Here, we investigated the role of stimulator of interferon genes (STING), a cytosolic DNA sensor, in atherogenesis. Apolipoprotein E-deficient (Apoe-/-) mice fed a western-type diet (WTD), a hypercholesterolaemic mouse model, showed higher STING expression and markers for DNA damage such as γH2AX, p53, and single-stranded DNA (ssDNA) accumulation in macrophages in the aorta compared with wild-type (WT) mice. The level of cGAMP, a STING agonist, in the aorta was higher in Apoe-/- mice. Genetic deletion of Sting in Apoe-/- mice reduced atherosclerotic lesions in the aortic arch, lipid, and macrophage accumulation in plaques, and inflammatory molecule expression in the aorta compared with the control. Pharmacological blockade of STING using a specific inhibitor, C-176, ameliorated atherogenesis in Apoe-/- mice. In contrast, bone marrow-specific STING expression in Apoe-/- mice stimulated atherogenesis. Expression or deletion of STING did not affect metabolic parameters and blood pressure. In vitro studies revealed that STING activation by cGAMP or mitochondrial DNA accelerated inflammatory molecule expression (e.g. TNF-α or IFN-β) in mouse and human macrophages. Activation of nuclear factor-κB and TANK binding kinase 1 was involved in STING-associated vascular inflammation and macrophage activation. Furthermore, human atherosclerotic lesions in the carotid arteries expressed STING and cGAMP. Stimulator of interferon genes stimulates pro-inflammatory activation of macrophages, leading to the development of atherosclerosis. Stimulator of interferon genes signalling may serve as a potential therapeutic target for atherosclerosis.
(出版サイトへのリンク): ● Publication site (DOI): 10.1093/eurheartj/ehab249
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34226923; ● Summary page in Scopus @ Elsevier: 2-s2.0-85120384111

(DOI: 10.1093/eurheartj/ehab249, PubMed: 34226923, Elsevier: Scopus) B Ganbaatar, Daiju Fukuda, M Shinohara, Shusuke Yagi, Kenya Kusunose, Hirotsugu Yamada, Takeshi Soeki, KI Hirata and Masataka Sata :
Inhibition of S1P Receptor 2 Attenuates Endothelial Dysfunction and Inhibits Atherogenesis in Apolipoprotein E-Deficient Mice,
Journal of Atherosclerosis and Thrombosis, Vol.28, No.6, 630-642, 2021.

(要約): The bioactive lipid, sphingosine-1-phosphate (S1P), has various roles in the physiology and pathophysiology of many diseases. There are five S1P receptors; however, the role of each S1P receptor in atherogenesis is still obscure. Here we investigated the contribution of S1P receptor 2 (S1P2) to atherogenesis by using a specific S1P2 antagonist, ONO-5430514, in apolipoprotein E-deficient (Apoe) mice. Apoe mice fed with a western-type diet (WTD) received ONO-5430514 (30 mg/kg/day) or vehicle. To examine the effect on atherogenesis, Sudan IV staining, histological analysis, qPCR, and vascular reactivity assay was performed. Human umbilical vein endothelial cells (HUVEC) were used for in vitro experiments. WTD-fed Apoe mice had significantly higher S1P2 expression in the aorta compared with wild-type mice. S1P2 antagonist treatment for 20 weeks reduced atherosclerotic lesion development (p<0.05). S1P2 antagonist treatment for 8 weeks ameliorated endothelial dysfunction (p<0.05) accompanied with significant reduction of lipid deposition, macrophage accumulation, and inflammatory molecule expression in the aorta compared with vehicle. S1P2 antagonist attenuated the phosphorylation of JNK in the abdominal aorta compared with vehicle (p<0.05). In HUVEC, S1P promoted inflammatory molecule expression such as MCP-1 and VCAM-1 p<0.001), which was attenuated by S1P2 antagonist or a JNK inhibitor (p<0.01). S1P2 antagonist also inhibited S1P-induced JNK phosphorylation in HUVEC (p<0.05). Our results suggested that an S1P2 antagonist attenuates endothelial dysfunction and prevents atherogenesis. S1P2, which promotes inflammatory activation of endothelial cells, might be a therapeutic target for atherosclerosis.
(徳島大学機関リポジトリ): ● Metadata: 116449
(出版サイトへのリンク): ● Publication site (DOI): 10.5551/jat.54916
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32879149; ● Search Scopus @ Elsevier (PMID): 32879149; ● Search Scopus @ Elsevier (DOI): 10.5551/jat.54916

(徳島大学機関リポジトリ: 116449, DOI: 10.5551/jat.54916, PubMed: 32879149) Y Okushi, Kenya Kusunose, Y Okayama, Robert Zheng, M Nakai, Y Sumita, Takayuki Ise, Takeshi Tobiume, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Acute Hospital Mortality of Venous Thromboembolism in Patients With Cancer From Registry Data,
Journal of the American Heart Association, Vol.10, No.11, e019373, 2021.

(要約): Background The prognosis of patients with cancer-venous thromboembolism (VTE) is not well known because of a lack of registry data. Moreover, there is also no knowledge on how specific types are related to prognosis. We sought to evaluate the clinical characteristics and outcomes of patients with cancer-associated VTE, compared with a matched cohort without cancer using real-world registry data of VTE. Methods and Results This study was based on the Diagnosis Procedure Combination database in the JROAD-DPC (Japanese Registry of All Cardiac and Vascular Diseases and the Diagnosis Procedure Combination). Of 5 106 151 total patients included in JROAD-DPC, we identified 49 580 patients who were first hospitalized with VTE from April 2012 to March 2017. Propensity score was estimated with a logistic regression model, with cancer as the dependent variable and 18 clinically relevant covariates. After propensity matching, there were 25 148 patients with VTE with or without cancer. On propensity score-matched analysis with 25 148 patients with VTE, patients with cancer had higher total in-hospital mortality within 7 days (1.3% versus 1.1%, odds ratio [OR], 1.66; 95% CI, 1.31-2.11; <0.0001), 14 days (2.5% versus 1.5%, OR, 2.07; 95% CI, 1.72-2.49; <0.0001), and 30 days (4.8% versus 2.0%, OR, 2.85; 95% CI, 2.45-3.31; <0.0001). On analysis for each type of cancer, in-hospital mortality in 11 types of cancer was significantly high, especially pancreas (OR, 12.96; 95% CI, 6.41-26.20), biliary tract (OR, 8.67; 95% CI, 3.00-25.03), and liver (OR, 7.31; 95% CI, 3.05-17.50). Conclusions Patients with cancer had a higher in-hospital acute mortality for VTE than those without cancer, especially in pancreatic, biliary tract, and liver cancers.
(徳島大学機関リポジトリ): ● Metadata: 116140
(出版サイトへのリンク): ● Publication site (DOI): 10.1161/JAHA.120.019373
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34027673; ● Search Scopus @ Elsevier (PMID): 34027673; ● Search Scopus @ Elsevier (DOI): 10.1161/JAHA.120.019373

(徳島大学機関リポジトリ: 116140, DOI: 10.1161/JAHA.120.019373, PubMed: 34027673) T Ogata, H Shimada, T Inoue, S Takeshita, Y Tsuboi, N Uesugi, M Fujiwara, Masataka Sata and Hirotsugu Yamada :
Quantification of Carotid Plaque Histology Using iPlaque Software,
Ultrasound in Medicine & Biology, Vol.47, No.4, 928-931, 2021.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.ultrasmedbio.2020.12.002
(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-85098957691

(DOI: 10.1016/j.ultrasmedbio.2020.12.002, Elsevier: Scopus) Miharu Arase, Kenya Kusunose, N Yamaguchi, Yukina Hirata, Susumu Nishio, Y Okushi, Takayuki Ise, Takeshi Tobiume, Koji Yamaguchi, Daiju Fukuda, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Cardiac reserve by 6-minute walk stress echocardiography in systemic sclerosis.,
Open Heart, Vol.8, No.1, e001559, 2021.

(徳島大学機関リポジトリ): ● Metadata: 116465
(出版サイトへのリンク): ● Publication site (DOI): 10.1136/openhrt-2020-001559
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1136/openhrt-2020-001559

(徳島大学機関リポジトリ: 116465, DOI: 10.1136/openhrt-2020-001559) Kenya Kusunose, Y Okushi, Y Okayama, Robert Zheng, M Abe, M Nakai, Y Sumita, Takayuki Ise, Takeshi Tobiume, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Association between Vitamin D and Heart Failure Mortality in 10,974 Hospitalized Individuals.,
Nutrients, Vol.13, No.2, 335, 2021.

(要約): A broad range of chronic conditions, including heart failure (HF), have been associated with vitamin D deficiency. Existing clinical trials involving vitamin D supplementation in chronic HF patients have been inconclusive. We sought to evaluate the outcomes of patients with vitamin D supplementation, compared with a matched cohort using real-world big data of HF hospitalization. This study was based on the Diagnosis Procedure Combination database in the Japanese Registry of All Cardiac and Vascular Datasets (JROAD-DPC). After exclusion criteria, we identified 93,692 patients who were first hospitalized with HF between April 2012 and March 2017 (mean age was 79 ± 12 years, and 52.2% were male). Propensity score (PS) was estimated with logistic regression model, with vitamin D supplementation as the dependent variable and clinically relevant covariates. On PS-matched analysis with 10,974 patients, patients with vitamin D supplementation had lower total in-hospital mortality (6.5 vs. 9.4%, odds ratio: 0.67, < 0.001) and in-hospital mortality within 7 days and 30 days (0.9 vs. 2.5%, OR, 0.34, and 3.8 vs. 6.5%, OR: 0.56, both < 0.001). In the sub-group analysis, mortalities in patients with age < 75, diabetes, dyslipidemia, atrial arrhythmia, cancer, renin-angiotensin system blocker, and β-blocker were not affected by vitamin D supplementation. Patients with vitamin D supplementation had a lower in-hospital mortality for HF than patients without vitamin D supplementation in the propensity matched cohort. The identification of specific clinical characteristics in patients benefitting from vitamin D may be useful for determining targets of future randomized control trials.
(徳島大学機関リポジトリ): ● Metadata: 116464
(出版サイトへのリンク): ● Publication site (DOI): 10.3390/nu13020335
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33498709; ● Summary page in Scopus @ Elsevier: 2-s2.0-85099832739

(徳島大学機関リポジトリ: 116464, DOI: 10.3390/nu13020335, PubMed: 33498709, Elsevier: Scopus) Gulinu Maimaituxun, Kenya Kusunose, Hirotsugu Yamada, Daiju Fukuda, Shusuke Yagi, Yuta Torii, Nao Yamada, Takeshi Soeki, H Masuzaki, Masataka Sata and Michio Shimabukuro :
Deleterious Effects of Epicardial Adipose Tissue Volume on Global Longitudinal Strain in Patients With Preserved Left Ventricular Ejection Fraction,
Frontiers in Cardiovascular Medicine, Vol.7, 607825, 2021.

(出版サイトへのリンク): ● Publication site (DOI): 10.3389/fcvm.2020.607825
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33521062; ● Search Scopus @ Elsevier (PMID): 33521062; ● Search Scopus @ Elsevier (DOI): 10.3389/fcvm.2020.607825

(DOI: 10.3389/fcvm.2020.607825, PubMed: 33521062) Akira Takashima, Shusuke Yagi, Koji Yamaguchi, Kiyoe Kurahashi, Yuko Kojima, Robert Zheng, Takayuki Ise, Kenya Kusunose, Sumiko Yoshida, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Ken-ichi Aihara, Masashi Akaike and Masataka Sata :
Congenital Hypogonadotropic Hypogonadism with Early-Onset Coronary Artery Disease.,
The Journal of Medical Investigation : JMI, Vol.68, No.1.2, 189-191, 2021.

(要約): The patient with congenital hypogonadotropic hypogonadism (HH) shows low serum levels of androgen, which is a group of sex hormones including testosterone, caused by the decreased gonadotropin release in the hypothalamus. Recent reports showed androgens exert protective effects against insulin resistance or atherosclerotic diseases, such as diabetes mellitus or coronary artery disease. However, whether the juvenile hypogonadism affects the diabetes or cardiovascular disease is unclear. We report a case of a middle-aged man with congenital HH who had severe coronary artery disease complicated with metabolic disorders. J. Med. Invest. 68 : 189-191, February, 2021.
(徳島大学機関リポジトリ): ● Metadata: 116019
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.68.189
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33994469; ● Search Scopus @ Elsevier (PMID): 33994469; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.68.189

(徳島大学機関リポジトリ: 116019, DOI: 10.2152/jmi.68.189, PubMed: 33994469) Yutaka Kawabata, Takeshi Soeki, Hiroyuki Ito, Tomomi Matsuura, Kenya Kusunose, Takayuki Ise, Koji Yamaguchi, Takeshi Tobiume, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Tetsuzo Wakatsuki, M Kitani, K Kawano, Y Taketani and Masataka Sata :
Effects of L-/N-Type Calcium Channel Blockers on Angiotensin II-Renin Feedback in Hypertensive Patients,
International Journal of Hypertension, 6653851, 2020.

(徳島大学機関リポジトリ): ● Metadata: 115937
(出版サイトへのリンク): ● Publication site (DOI): 10.1155/2020/6653851
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33489354; ● Summary page in Scopus @ Elsevier: 2-s2.0-85098701678

(徳島大学機関リポジトリ: 115937, DOI: 10.1155/2020/6653851, PubMed: 33489354, Elsevier: Scopus) Takeshi Tobiume, R Kato, Tomomi Matsuura, Kazuhisa Matsumoto, M Hara, N Takamori, Y Taketani, K Okwa, Takayuki Ise, Kenya Kusunose, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Tetsuzo Wakatsuki, Takeshi Soeki, Masataka Sata and K Matsumoto :
Antegrade slow pathway mapping of typical atrioventricular nodal reentrant tachycardia based on direct slow pathway capture,
Journal of Arrhythmia, Vol.37, No.1, 128-139, 2020.

(徳島大学機関リポジトリ): ● Metadata: 116343
(出版サイトへのリンク): ● Publication site (DOI): 10.1002/joa3.12484
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33664895; ● Summary page in Scopus @ Elsevier: 2-s2.0-85099515348

(徳島大学機関リポジトリ: 116343, DOI: 10.1002/joa3.12484, PubMed: 33664895, Elsevier: Scopus) Yoshihito Saijyo, Kenya Kusunose, Y Okushi, Hirotsugu Yamada, Hiroaki Toba and Masataka Sata :
Relationship between regional left ventricular dysfunction and cancer-therapy-related cardiac dysfunction,
Heart, Vol.106, No.22, 1752-1758, 2020.

(要約): The aim of our study was to assess the association between risk of cancer-therapy-related cardiac dysfunction (CTRCD) after first follow-up and the difference in echocardiographic measures from baseline to follow-up. We retrospectively enrolled 87 consecutive patients (58±14 years, 55 women) who received anthracycline and underwent echocardiographic examinations both before (baseline) and after initial anthracycline administration (first follow-up). We measured absolute values of global longitudinal strain (GLS), apical longitudinal strain (LS), mid-LS and basal-LS at baseline and first follow-up, and per cent changes (Δ) of these parameters were calculated. Among 61 patients who underwent further echocardiographic examinations (second follow-up, third follow-up, etc), we assessed the association between regional left ventricular (LV) systolic dysfunction from baseline to follow-up and development of CTRCD, defined as LV ejection fraction (LVEF) under 53% and more absolute decrease of 10% from baseline, after first follow-up. LVEF (65%±4% vs 63±4%, p=0.004), GLS (23.2%±2.6% vs 22.2±2.4%, p=0.005) and basal-LS (21.9%±2.5% vs 19.9±2.4%, p<0.001) at first follow-up significantly decreased compared with baseline. Among the 61 patients who had further follow-up echocardiographic examinations, 13% developed CTRCD. In the Cox-hazard model, worse Δbasal-LS was significantly associated with CTRCD. By Kaplan-Meier analysis, patients with Δbasal-LS decrease of more than the median value (-9.7%) had significantly worse event-free survival than those with a smaller decrease (p=0.015). Basal-LS significantly decreased prior to development of CTRCD, and worse basal-LS was associated with development of CTRCD in patients receiving anthracycline chemotherapy.
(キーワード): Antibiotics, Antineoplastic / Cardiotoxicity / Echocardiography / Female / Follow-Up Studies / Heart Diseases / Humans / Male / Middle Aged / Neoplasms / Retrospective Studies / Risk Factors / Stroke Volume / Ventricular Dysfunction, Left / Ventricular Function, Left
(出版サイトへのリンク): ● Publication site (DOI): 10.1136/heartjnl-2019-316339
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32209616; ● Search Scopus @ Elsevier (PMID): 32209616; ● Search Scopus @ Elsevier (DOI): 10.1136/heartjnl-2019-316339

(DOI: 10.1136/heartjnl-2019-316339, PubMed: 32209616) Kenya Kusunose, nao Yamada, Hirotsugu Yamada, Susumu Nishio, Yoshihito Saijoh, Yukina Hirata, Yuta Torii, Takayuki Ise, Koji Yamaguchi, Daiju Fukuda, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Association between Right Ventricular Contractile Function and Cardiac Events in Isolated Post-capillary and Combined Pre- and Post-capillary Pulmonary Hypertension,
Journal of Cardiac Failure, Vol.26, No.1, 43-51, 2020.

(要約): Recent studies have shown that patients with combined pre- and postcapillary pulmonary hypertension (CpcPH) had worse outcomes than those with isolated postcapillary pulmonary hypertension (IpcPH). However, the prognostic factors including right ventricular (RV) function have not been well documented. The aim of this study was to assess the differentiation of PH phenotypes, using echocardiography, and the association between RV longitudinal strain and cardiac events. We prospectively recruited consecutive patients who had undergone right heart catheterization. The primary endpoint was cardiovascular death or readmission due to heart failure. We included 137 patients with Group 2 PH. A RV longitudinal strain of 17% was sensitive (85%) and specific (70%) to determine the CpcPH. During a median period of 31 months, 43 patients experienced the primary endpoint during follow-up. In a multivariate analysis, RV longitudinal strain was associated with the primary endpoint in both CpcPH and IpcPH (HR: 0.84, P = 0.003; HR: 0.86, P = 0.001). Lower RV longitudinal strain was independently associated with worse outcomes in CpcPH and IpcPH. RV longitudinal strain may play a prognostic role in PH phenotypes.
(徳島大学機関リポジトリ): ● Metadata: 114190
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.cardfail.2019.08.021
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31487533; ● Summary page in Scopus @ Elsevier: 2-s2.0-85072539026

(徳島大学機関リポジトリ: 114190, DOI: 10.1016/j.cardfail.2019.08.021, PubMed: 31487533, Elsevier: Scopus) 平田有紀奈, 西尾進, 楠瀬賢也, 藤田幸那, 荒瀬美晴, 山田博胤, 佐田政隆 :
最新の心エコー図診断装置および装置非依存性ストレイン解析ソフトウェアを用いたGlobal Longitudinal Strain計測の装置間差に関する検討,
超音波検査技術, Vol.45, No.4, 405-413, 2020年.

(要約): 目的:左室長軸方向ストレイン(GLS)は，正確で再現性の良い左室機能評価の指標とされているが，超音波診断装置間でのばらつきは未だ議論がある．本研究では，最新の超音波診断装置を用いることにより，GLSの装置間差が軽減しているという仮説を検証することを目的とした．対象と方法: 34名の健康なボランティアの測定を行った．心尖部の画像は，徳島大学病院超音波センターに導入された最新の超音波装置を使用して取得した．GLSの測定はそれぞれの装置に搭載されているソフトウェアおよび，装置非依存性ストレイン解析ソフトウェアであるEchoInsightを用いて測定し，比較した．結果と考察:各装置間でGLSに良好な相関が得られた(GE vs. Philips[r＝0.678, p<0.001, Bias 1.1%, 2SD ±2.9%]，GE vs. Canon[r＝0.690, p<0.001, Bias 0.4%, 2SD ±2.5%]，Philips vs. Canon[r＝0.551, p<0.001, Bias 1.5%, 2SD ±3.2%])．EchoInsightを用いた場合，各装置で計測したGLSよりも相関関係は良好であった．結語:GLSの装置間差は過去の報告と比較して改善していた．さらにEchoInsightを用いて計測したGLSは，良好な相関関係を認めた．
(キーワード): intervendor variability / speckle-tracking echocardiography / 2D strain
(出版サイトへのリンク): ● Publication site (DOI): 10.11272/jss.316
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390848250135697408; ● Search Scopus @ Elsevier (DOI): 10.11272/jss.316

(DOI: 10.11272/jss.316, CiNii: 1390848250135697408) Yuta Torii, Kenya Kusunose, Robert Zheng, Hirotsugu Yamada, Rie Amano, Rikizo Matsumoto, Yukina Hirata, Susumu Nishio, Nao Yamada, Takayuki Ise, Koji Yamaguchi, Takeshi Tobiume, Daiju Fukuda, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki, Yoshihiro Okayama and Masataka Sata :
Association between Sarcopenia/Lower Muscle Mass and Short-Term Regression of Deep Vein Thrombosis Using Direct Oral Anticoagulants,
International Heart Journal, Vol.61, No.4, 787-794, 2020.

(要約): Advanced age, obesity, and muscle weakness are independent factors in the onset of deep vein thrombosis (DVT). Recently, an association between sarcopenia and DVT has been reported. We hypothesized that sarcopenia related factors, observed by ultrasonography, are associated with the regression effect on the thrombus following anticoagulation therapy. The present study focused on gastrocnemius muscle (GCM) thickness and the GCM's internal echogenic brightness. We examined the association with DVT regression following direct oral anticoagulants (DOACs) treatment.The prospective cohort study period was between October 2017 and August 2018. We enrolled 46 patients diagnosed with DVT by ultrasonography, who were aged >60 years old and treated with DOACs. Sarcopenia was evaluated using the Asian Working Group for Sarcopenia flowchart. The average DOACs treatment period was 94 days, and 29 patients exhibited thrombus regression. On univariate logistic regression analysis, sarcopenia, average GCM diameter index, and gastrocnemius integrated backscatter index were significantly associated with thrombus regression. In a multivariate model, only the average GCM diameter index correlated with thrombus regression.The average GCM diameter index is associated with DVT regression treated with DOACs. Considering the GCM diameter during DVT treatment can be a marker to make a decision for the treatment of DVT.
(キーワード): Aged / Aged, 80 and over / Factor Xa Inhibitors / 女性 (female) / Humans / 男性 (male) / Middle Aged / Muscle, Skeletal / Prospective Studies / Sarcopenia / Ultrasonography / Venous Thrombosis
(出版サイトへのリンク): ● Publication site (DOI): 10.1536/ihj.20-032
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32684602; ● Summary page in Scopus @ Elsevier: 2-s2.0-85088879684

(DOI: 10.1536/ihj.20-032, PubMed: 32684602, Elsevier: Scopus) Kenya Kusunose, M Fujiwara, Hirotsugu Yamada, Susumu Nishio, Y Saijo, N Yamada, Yukina Hirata, Yuta Torii, Takayuki Ise, Koji Yamaguchi, Daiju Fukuda, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Deterioration of Biventricular Strain Is an Early Marker of Cardiac Involvement in Confirmed Sarcoidosis,
European Heart Journal Cardiovascular Imaging, Vol.21, No.7, 796-804, 2020.

(要約): Risk assessment of developing cardiac involvement in systemic sarcoidosis can be challenging because of limited data. Recently, attention has been given to left ventricular and right ventricular (LV and RV) involvement in cardiac sarcoidosis (CS) and its prevalence, relevance, and prognostic value. The aim of this study was to assess the role of biventricular strain to predict prognosis in confirmed sarcoidosis patients. LV and RV longitudinal strains (LSs) were evaluated by 2D speckle tracking in 139 consecutive confirmed sarcoidosis patients without other pre-existing structural heart diseases, and 52 age- and gender-matched control subjects. The primary endpoint was CS-related events (cardiac death or development of cardiac involvement). Sarcoidosis without cardiac involvement had significantly lower LV and RV free wall LS compared with control subjects. Basal LS had a higher area under the curve for differentiation of sarcoidosis in patients without cardiac involvement compared to control (cut-off value: -18% with 89% sensitivity and 69% specificity). During a median period of 50 months, the occurrence of CS-related events was observed in 20 patients. In a multivariate analysis, basal LV LS and RV free wall LS were associated with the events [hazard ratio (HR) 0.72, P < 0.001 and HR: 0.83, P = 0.006, respectively]. Patients with impaired biventricular function had significantly shorter event-free survival than those with preserved biventricular function (P < 0.001). Deterioration of biventricular strain was associated with CS-related events. This information might be useful for clinical evaluation and follow-up in sarcoidosis.
(出版サイトへのリンク): ● Publication site (DOI): 10.1093/ehjci/jez235
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31566217; ● Summary page in Scopus @ Elsevier: 2-s2.0-85086792785

(DOI: 10.1093/ehjci/jez235, PubMed: 31566217, Elsevier: Scopus) 山田博胤, 楠瀬賢也 :
心エコー図法とAI,
循環器内科, Vol.88, No.1, 66-71, 2020年.

(キーワード): artificial intelligence (AI) / echocardiography / deep learning
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1521417755504076160

(CiNii: 1521417755504076160) Kenya Kusunose, Takashi Abe, Akihiro Haga, Daiju Fukuda, Hirotsugu Yamada, Masafumi Harada and Masataka Sata :
A Deep Learning Approach for Assessment of Regional Wall Motion Abnormality From Echocardiographic Images,
JACC. Cardiovascular Imaging, Vol.13, No.2, 374-381, 2020.

(要約): This study investigated whether a deep convolutional neural network (DCNN) could provide improved detection of regional wall motion abnormalities (RWMAs) and differentiate among groups of coronary infarction territories from conventional 2-dimensional echocardiographic images compared with that of cardiologists, sonographers, and resident readers. An effective intervention for reduction of misreading of RWMAs is needed. The hypothesis was that a DCNN trained using echocardiographic images would provide improved detection of RWMAs in the clinical setting. A total of 300 patients with a history of myocardial infarction were enrolled. From this cohort, 3 groups of 100 patients each had infarctions of the left anterior descending (LAD) artery, the left circumflex (LCX) branch, and the right coronary artery (RCA). A total of 100 age-matched control patients with normal wall motion were selected from a database. Each case contained cardiac ultrasonographs from short-axis views at end-diastolic, mid-systolic, and end-systolic phases. After the DCNN underwent 100 steps of training, diagnostic accuracies were calculated from the test set. Independently, 10 versions of the same model were trained, and ensemble predictions were performed using those versions. For detection of the presence of WMAs, the area under the receiver-operating characteristic curve (AUC) produced by the deep learning algorithm was similar to that produced by the cardiologists and sonographer readers (0.99 vs. 0.98, respectively; p = 0.15) and significantly higher than the AUC result of the resident readers (0.99 vs. 0.90, respectively; p = 0.002). For detection of territories of WMAs, the AUC by the deep learning algorithm was similar to the AUC by the cardiologist and sonographer readers (0.97 vs. 0.95, respectively; p = 0.61) and significantly higher than the AUC by resident readers (0.97 vs. 0.83, respectively; p = 0.003). From a validation group at an independent site (n = 40), the AUC by the deep learning algorithm was 0.90. The present results support the possibility of using DCNN for automated diagnosis of RWMAs in the field of echocardiography.
(徳島大学機関リポジトリ): ● Metadata: 114196
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jcmg.2019.02.024
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31103590; ● Summary page in Scopus @ Elsevier: 2-s2.0-85070068493

(徳島大学機関リポジトリ: 114196, DOI: 10.1016/j.jcmg.2019.02.024, PubMed: 31103590, Elsevier: Scopus) Kenya Kusunose, Akihiro Haga, Mizuki Inoue, Daiju Fukuda, Hirotsugu Yamada and Masataka Sata :
Clinically Feasible and Accurate View Classification of Echocardiographic Images Using Deep Learning,
Biomolecules, Vol.10, No.5, E665, 2020.

(要約): A proper echocardiographic study requires several video clips recorded from different acquisition angles for observation of the complex cardiac anatomy. However, these video clips are not necessarily labeled in a database. Identification of the acquired view becomes the first step of analyzing an echocardiogram. Currently, there is no consensus whether the mislabeled samples can be used to create a feasible clinical prediction model of ejection fraction (EF). The aim of this study was to test two types of input methods for the classification of images, and to test the accuracy of the prediction model for EF in a learning database containing mislabeled images that were not checked by observers. We enrolled 340 patients with five standard views (long axis, short axis, 3-chamber view, 4-chamber view and 2-chamber view) and 10 images in a cycle, used for training a convolutional neural network to classify views (total 17,000 labeled images). All DICOM images were rigidly registered and rescaled into a reference image to fit the size of echocardiographic images. We employed 5-fold cross validation to examine model performance. We tested models trained by two types of data, averaged images and 10 selected images. Our best model (from 10 selected images) classified video views with 98.1% overall test accuracy in the independent cohort. In our view classification model, 1.9% of the images were mislabeled. To determine if this 98.1% accuracy was acceptable for creating the clinical prediction model using echocardiographic data, we tested the prediction model for EF using learning data with a 1.9% error rate. The accuracy of the prediction model for EF was warranted, even with training data containing 1.9% mislabeled images. The CNN algorithm can classify images into five standard views in a clinical setting. Our results suggest that this approach may provide a clinically feasible accuracy level of view classification for the analysis of echocardiographic data.
(徳島大学機関リポジトリ): ● Metadata: 115024
(出版サイトへのリンク): ● Publication site (DOI): 10.3390/biom10050665
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32344829; ● Summary page in Scopus @ Elsevier: 2-s2.0-85083901945

(徳島大学機関リポジトリ: 115024, DOI: 10.3390/biom10050665, PubMed: 32344829, Elsevier: Scopus) Hiroyuki Ito, Tetsuzo Wakatsuki, Koji Yamaguchi, Daiju Fukuda, Yutaka Kawabata, Tomomi Matsuura, Kenya Kusunose, Takayuki Ise, Takeshi Tobiume, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Yoshihiro Tsuruo and Masataka Sata :
Atherosclerotic Coronary Plaque Is Associated With Adventitial Vasa Vasorum and Local Inflammation in Adjacent Epicardial Adipose Tissue in Fresh Cadavers,
Circulation Journal, Vol.84, No.5, 769-775, 2020.

(徳島大学機関リポジトリ): ● Metadata: 116640
(出版サイトへのリンク): ● Publication site (DOI): 10.1253/circj.CJ-19-0914
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32281556; ● Summary page in Scopus @ Elsevier: 2-s2.0-85083919450

(徳島大学機関リポジトリ: 116640, DOI: 10.1253/circj.CJ-19-0914, PubMed: 32281556, Elsevier: Scopus) B Ganbaatar, Daiju Fukuda, M Shinohara, Shusuke Yagi, Kenya Kusunose, Hirotsugu Yamada, Takeshi Soeki, KI Hirata and Masataka Sata :
Empagliflozin Ameliorates Endothelial Dysfunction and Suppresses Atherogenesis in Diabetic Apolipoprotein E-deficient Mice,
European Journal of Pharmacology, Vol.15, No.875, 173040, 2020.

(要約): Recent studies reported cardioprotective effects of sodium glucose co-transporter 2 (SGLT2) inhibitors; however, the underlying mechanisms are still obscure. Here, we investigated whether empagliflozin attenuates atherogenesis and endothelial dysfunction in diabetic apolipoprotein E-deficient (ApoE) mice. Male streptozotocin (STZ) - induced diabetic ApoE mice were treated with empagliflozin for 12 or 8 weeks. Empagliflozin lowered blood glucose (P < 0.001) and lipid levels in diabetic ApoE mice. Empagliflozin treatment for 12 weeks significantly decreased atherosclerotic lesion size in the aortic arch (P < 0.01) along with reduction of lipid deposition (P < 0.05), macrophage accumulation (P < 0.001), and inflammatory molecule expression in plaques compared with the untreated group. Empagliflozin treatment for 8 weeks significantly ameliorated diabetes-induced endothelial dysfunction as determined by the vascular response to acetylcholine (P < 0.001). Empagliflozin reduced RNA expression of a macrophage marker, CD68, and inflammatory molecules such as MCP-1 (P < 0.05) and NADPH oxidase subunits in the aorta compared with the untreated group. Empagliflozin also reduced plasma levels of vasoconstrictive eicosanoids, prostaglandin E and thromboxane B (P < 0.001), which were elevated in diabetic condition. Furthermore, empagliflozin attenuated RNA expression of inflammatory molecules in perivascular adipose tissue (PVAT), suggesting the reduction of inflammation in PVAT. In in vitro studies, methylglyoxal (MGO), a precursor of AGEs, significantly increased the expression of inflammatory molecules such as MCP-1 and TNF-α in a murine macrophage cell line, RAW264.7. Our results indicated that empagliflozin attenuated endothelial dysfunction and atherogenesis in diabetic ApoE mice. Reduction of vasoconstrictive eicosanoids and inflammation in the vasculature and PVAT may have a role as underlying mechanisms at least partially.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.ejphar.2020.173040
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32114052; ● Summary page in Scopus @ Elsevier: 2-s2.0-85080985939

(DOI: 10.1016/j.ejphar.2020.173040, PubMed: 32114052, Elsevier: Scopus) Yoshihito Saijo, Kenya Kusunose, Nao Yamada, Hirotsugu Yamada, Susumu Nishio, Yukina Hirata and Masataka Sata :
Sequential speckle tracking imaging to detect early stage of cancer therapeutics-related cardiac dysfunction in a patient with breast cancer,
Journal of Echocardiography, Vol.18, No.2, 134-135, 2020.

(徳島大学機関リポジトリ): ● Metadata: 113232
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s12574-019-00423-2
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30810909; ● Summary page in Scopus @ Elsevier: 2-s2.0-85062643604

(徳島大学機関リポジトリ: 113232, DOI: 10.1007/s12574-019-00423-2, PubMed: 30810909, Elsevier: Scopus) Arief Rahadian, Daiju Fukuda, HM Salim, Shusuke Yagi, Kenya Kusunose, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Canagliflozin Prevents Diabetes-Induced Vascular Dysfunction in ApoE-Deficient Mice,
Journal of Atherosclerosis and Thrombosis, Vol.27, No.11, 1141-1151, 2020.

(要約): Recent studies have demonstrated that selective sodium-glucose cotransporter 2 inhibitors (SGLT2is) reduce cardiovascular events, although their mechanism remains obscure. We examined the effect of canagliflozin, an SGLT2i, on atherogenesis and investigated its underlying mechanism. Canagliflozin (30 mg/kg/day) was administered by gavage to streptozotocin-induced diabetic apolipoprotein E-deficient (ApoE) mice. Sudan IV staining was performed at the aortic arch. Immunostaining, quantitative RT-PCR, and vascular reactivity assay were performed using the aorta. In vitro experiments using human umbilical vein endothelial cells (HUVECs) were also performed. Canagliflozin decreased blood glucose (P<0.001) and total cholesterol (P<0.05) levels. Sudan IV staining showed that 12-week canagliflozin treatment decreased atherosclerotic lesions (P<0.05). Further, 8-week canagliflozin treatment ameliorated endothelial dysfunction, as determined by acetylcholine-induced vasodilation (P<0.05), and significantly reduced the expressions of inflammatory molecules such as ICAM-1 and VCAM-1 in the aorta at the RNA and protein levels. Canagliflozin also reduced the expressions of NADPH oxidase subunits such as NOX2 and p22phox in the aorta and reduced urinary excretion of 8-OHdG, suggesting a reduction in oxidative stress. Methylglyoxal, a precursor of advanced glycation end products, increased the expressions of ICAM-1 and p22phox in HUVECs (P<0.05, both). Methylglyoxal also decreased the phosphorylation of eNOS and Akt but increased the phosphorylation of eNOS and p38 MAPK in HUVECs. Canagliflozin prevents endothelial dysfunction and atherogenesis in diabetic ApoE mice. Anti-inflammatory and antioxidative potential due to reduced glucose toxicity to endothelial cells might be its underlying mechanisms.
(徳島大学機関リポジトリ): ● Metadata: 115926
(出版サイトへのリンク): ● Publication site (DOI): 10.5551/jat.52100
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32101837; ● CiNii @ 国立情報学研究所 (CRID): 1390286426514028416; ● Search Scopus @ Elsevier (PMID): 32101837; ● Search Scopus @ Elsevier (DOI): 10.5551/jat.52100

(徳島大学機関リポジトリ: 115926, DOI: 10.5551/jat.52100, PubMed: 32101837, CiNii: 1390286426514028416) Kenya Kusunose, Akihiro Haga, Natsumi Yamaguchi, Takashi Abe, Daiju Fukuda, Hirotsugu Yamada, Masafumi Harada and Masataka Sata :
Deep Learning for Assessment of Left Ventricular Ejection Fraction from Echocardiographic Images,
Journal of the American Society of Echocardiography, Vol.33, No.5, 632-635, 2020.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.echo.2020.01.009
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32111541; ● Summary page in Scopus @ Elsevier: 2-s2.0-85080044447

(DOI: 10.1016/j.echo.2020.01.009, PubMed: 32111541, Elsevier: Scopus) Akihiro Tani, Kenya Kusunose, Kazuhisa Mastumoto, Hirotsugu Yamada and Masataka Sata :
Diastolic Mitral Regurgitation on Color M-Mode Echocardiography in a Patient With Complete Atrioventricular Block.,
Circulation Reports, Vol.2, No.3, 207-208, 2020.

(出版サイトへのリンク): ● Publication site (DOI): 10.1253/circrep.CR-20-0002
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33693230; ● Search Scopus @ Elsevier (PMID): 33693230; ● Search Scopus @ Elsevier (DOI): 10.1253/circrep.CR-20-0002

(DOI: 10.1253/circrep.CR-20-0002, PubMed: 33693230) 平田有紀奈, 西尾進, 原田修, 宮里尚美, 原國督, 楠瀬賢也, 伊藤敦彦, 山田博胤, 佐田政隆 :
冠動脈疾患の予測における心外膜下脂肪厚計測の有用性について:多施設共同研究,
超音波検査技術, Vol.45, No.1, 11-20, 2020年.

(出版サイトへのリンク): ● Publication site (DOI): 10.11272/jss.302
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.11272/jss.302

(DOI: 10.11272/jss.302) Maimaituxun Gulinu, Hirotsugu Yamada, Daiju Fukuda, Shusuke Yagi, Kenya Kusunose, Hirata Yukina, Nishio Susumu, Takeshi Soeki, Masuzaki Hiroaki, Masataka Sata and Michio Shimabukuro :
Association of Local Epicardial Adipose Tissue Depots and Left Ventricular Diastolic Performance in Patients With Preserved Left Ventricular Ejection Fraction,
Circulation Journal, Vol.84, No.2, 203-216, 2020.

(出版サイトへのリンク): ● Publication site (DOI): 10.1253/circj.CJ-19-0793
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31956209; ● Summary page in Scopus @ Elsevier: 2-s2.0-85079208017

(DOI: 10.1253/circj.CJ-19-0793, PubMed: 31956209, Elsevier: Scopus) Arief Rahadian, Daiju Fukuda, HM Salim, Shusuke Yagi, Kenya Kusunose, Hirotsugu Yamada, Takeshi Soeki, Michio Shimabukuro and Masataka Sata :
Thrombin inhibition by dabigatran attenuates endothelial dysfunction in diabetic mice,
Vascular Pharmacology, Vol.124, 106632, 2020.

(要約): Diabetic patients have coagulation abnormalities, in which thrombin plays a key role. Whereas accumulating evidence suggests that it also contributes to the development of vascular dysfunction through the activation of protease-activated receptors (PARs). Here we investigated whether the blockade of thrombin attenuates endothelial dysfunction in diabetic mice. Induction of diabetes by streptozotocin (STZ) increased the expression of PAR1, PAR3, and PAR4 in the aorta. STZ-induced diabetic mice showed impairment of endothelial function, while the administration of dabigatran etexilate, a direct thrombin inhibitor, significantly attenuated endothelial dysfunction in diabetic mice with no alteration of metabolic parameters including blood glucose level. Dabigatran did not affect endothelium-independent vasodilation. Dabigatran decreased the expression of inflammatory molecules (e.g., MCP-1 and ICAM-1) in the aorta of diabetic mice. Thrombin increased the expression of these inflammatory molecules and the phosphorylation of IκBα, and decreased the phosphorylation of eNOS in human umbilical endothelial cells (HUVEC). Thrombin significantly impaired the endothelium-dependent vascular response of aortic rings obtained from wild-type mice. Inhibition of NF-κB attenuated thrombin-induced inflammatory molecule expression in HUVEC and ameliorated thrombin-induced endothelial dysfunction in aortic rings. Dabigatran attenuated the development of diabetes-induced endothelial dysfunction. Thrombin signaling may serve as a potential therapeutic target in diabetic condition.
(徳島大学機関リポジトリ): ● Metadata: 114211
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.vph.2019.106632
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31759113; ● Search Scopus @ Elsevier (PMID): 31759113; ● Search Scopus @ Elsevier (DOI): 10.1016/j.vph.2019.106632

(徳島大学機関リポジトリ: 114211, DOI: 10.1016/j.vph.2019.106632, PubMed: 31759113) Yukina Hirata, Kenya Kusunose, Hirokazu Miki and Hirotsugu Yamada :
Improvement of global longitudinal strain following high-dose chemotherapy and autologous peripheral blood stem cell transplantation in patients with amyloid light-chain cardiac amyloidosis: a case report.,
European Heart Journal. Case Reports, Vol.3, No.4, 1-6, 2019.

(要約): Cardiac amyloidosis (CA) is a secondary form of cardiomyopathy where abnormal accumulation of amyloid protein in the myocardial interstitium causes cardiac hypertrophy and myocardial fibrosis. If primary CA advances to heart failure, most patients do not survive for very long after the diagnosis. A 40-year-old man was admitted to our hospital for dyspnoea, progressive anaemia, and decreased appetite. He has diagnosed with amyloid light-chain (AL) amyloidosis. Although BD treatment (bortezomib + dexamethasone) and medical treatment were started, there was no sign of improvement. Then, high-dose chemotherapy followed by autologous peripheral blood stem cell transplantation (auto-PBSCT) was initiated. Pretreatment echocardiography revealed typical findings of CA, such as ventricular wall thickening, valvular thickening, diastolic dysfunction, and pericardial effusion. Global longitudinal strain (GLS) was significantly reduced, and bull's-eye mapping showed typical apical sparing. After auto-PBSCT, GLS gradually improved and was almost normal after 2 years. Other echocardiographic parameters, functional status, and laboratory data also showed that there was significant regression of CA. Although the prognosis in primary CA is extremely poor, we achieved long-term survival in a patient with effective high-dose chemotherapy and auto-PBSCT. Global longitudinal strain may be a useful marker of prognosis, regression, and recovery.
(徳島大学機関リポジトリ): ● Metadata: 115842
(出版サイトへのリンク): ● Publication site (DOI): 10.1093/ehjcr/ytz225
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31911987; ● Summary page in Scopus @ Elsevier: 2-s2.0-85079442682

(徳島大学機関リポジトリ: 115842, DOI: 10.1093/ehjcr/ytz225, PubMed: 31911987, Elsevier: Scopus) K Aini, Daiju Fukuda, K Tanaka, Y Higashikuni, Yukina Hirata, Shusuke Yagi, Kenya Kusunose, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Vildagliptin, a DPP-4 Inhibitor, Attenuates Endothelial Dysfunction and Atherogenesis in Nondiabetic Apolipoprotein E-Deficient Mice,
International Heart Journal, Vol.60, No.6, 1421-1429, 2019.

(要約): Dipeptidyl peptidase-4 (DPP-4) inhibitors are novel antidiabetic agents with possible vascular protection effects. Endothelial dysfunction is an initiation step in atherogenesis. The purpose of this study was to investigate whether vildagliptin (Vilda) attenuates the development of endothelial dysfunction and atherosclerotic lesions in nondiabetic apolipoprotein E-deficient (ApoE) mice. Eight-week-old nondiabetic ApoE mice fed a Western-type diet received Vilda (50 mg/kg/day) for 20 weeks or 8 weeks. After 20 weeks of treatment, Vilda administration reduced atherogenesis in the aortic arch as determined by en face Sudan IV staining compared with the vehicle group (P < 0.05). Vilda also reduced lipid accumulation (P < 0.05) and vascular cell adhesion molecule-1 (VCAM-1) expression (P < 0.05) and tended to decrease macrophage infiltration (P = 0.05) into atherosclerotic plaques compared with vehicle. After 8 weeks of treatment, endothelium-dependent vascular reactivity was examined. Vilda administration significantly attenuated the impairment of endothelial function in nondiabetic ApoE mice compared with the vehicle group (P < 0.05). Vilda treatment did not alter metabolic parameters, including blood glucose level, in both study protocols. To investigate the mechanism, aortic segments obtained from wild-type mice were incubated with exendin-4 (Ex-4), a glucagon-like peptide-1 (GLP-1) analog, in the presence or absence of lipopolysaccharide (LPS). Ex-4 attenuated the impairment of endothelium-dependent vasodilation induced by LPS (P < 0.01). Furthermore, Ex-4 promoted phosphorylation of eNOS at Ser1177 which was decreased by LPS in human umbilical endothelial cells (P < 0.05). Vilda inhibited the development of endothelial dysfunction and prevented atherogenesis in nondiabetic ApoE mice. Our results suggested that GLP-1-dependent amelioration of endothelial dysfunction is associated with the atheroprotective effects of Vilda.
(キーワード): Animals / Apolipoproteins E / Atherosclerosis / Cell Culture Techniques / Dipeptidyl-Peptidase IV Inhibitors / Disease Models, Animal / Endothelial Cells / Endothelium, Vascular / Mice / Mice, Inbred C57BL / Vascular Cell Adhesion Molecule-1 / Vildagliptin
(徳島大学機関リポジトリ): ● Metadata: 114212
(出版サイトへのリンク): ● Publication site (DOI): 10.1536/ihj.19-117
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31735774; ● Summary page in Scopus @ Elsevier: 2-s2.0-85075961168

(徳島大学機関リポジトリ: 114212, DOI: 10.1536/ihj.19-117, PubMed: 31735774, Elsevier: Scopus) Kenya Kusunose, Yuta Torii, Hirotsugu Yamada, Susumu Nishio, Yukina Hirata, Yoshihito Saijoh, Takayuki Ise, Koji Yamaguchi, Daiju Fukuda, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Association of Echocardiography Before Major Elective Non-Cardiac Surgery With Improved Postoperative Outcomes - Possible Implications for Patient Care.,
Circulation Journal, Vol.83, No.12, 2512-2519, 2019.

(要約): Whether preoperative echocardiography improves postoperative outcomes is not well established, so we examined the value of echocardiographic assessment on the onset of postoperative heart failure (HF), and determining which patients benefitted most from undergoing echocardiography prior to major elective non-cardiac surgery.Methods and Results:We identified all patients aged 50 years and older who had major elective non-cardiac surgery, and excluded patients with previously identified severe cardiovascular disease. The primary endpoint was the onset of HF during hospitalization. A total of 806 patients were included in the analysis. During hospitalization, 49 patients (6%) reached the primary endpoint. Within the matched cohort, preoperative echocardiography was associated with a statistically significant decrease in postoperative HF (hazard ratio: 0.46, P=0.01). In subgroup analyses, age, sex, body surface area, hypertension, diabetes mellitus, prior HF, surgical type, chronic kidney disease, pulmonary disease, and malignancy influenced the association of echocardiography with postoperative HF. The use of echocardiography in elderly patients with certain risk factors was associated with improved postoperative outcomes. The basis for this finding remains to be determined; particularly whether echocardiography is simply a marker of a population with better outcomes or whether it leads to better management that improves outcomes.
(キーワード): Aged / Echocardiography / Female / Heart Failure / Humans / Incidence / Japan / Male / Middle Aged / Predictive Value of Tests / Preoperative Care / Retrospective Studies / Risk Assessment / Risk Factors / Surgical Procedures, Operative / Time Factors / Treatment Outcome
(徳島大学機関リポジトリ): ● Metadata: 114189
(出版サイトへのリンク): ● Publication site (DOI): 10.1253/circj.CJ-19-0663
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31611537; ● Search Scopus @ Elsevier (PMID): 31611537; ● Search Scopus @ Elsevier (DOI): 10.1253/circj.CJ-19-0663

(徳島大学機関リポジトリ: 114189, DOI: 10.1253/circj.CJ-19-0663, PubMed: 31611537) Kenya Kusunose, Hirotsugu Yamada, Susumu Nishio, Yukina Hirata, Yoshihito Saijoh, Yuta Torii, nao Yamada, Takayuki Ise, Koji Yamaguchi, Daiju Fukuda, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Pulmonary Artery Hypertension-Specific Therapy Improves Exercise Tolerance and Outcomes in Exercise-Induced Pulmonary Hypertension,
JACC. Cardiovascular Imaging, Vol.12, No.12, 2576-2579, 2019.

(徳島大学機関リポジトリ): ● Metadata: 114191
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jcmg.2019.07.002
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31422131; ● Search Scopus @ Elsevier (PMID): 31422131; ● Search Scopus @ Elsevier (DOI): 10.1016/j.jcmg.2019.07.002

(徳島大学機関リポジトリ: 114191, DOI: 10.1016/j.jcmg.2019.07.002, PubMed: 31422131) PT Pham, Daiju Fukuda, Shusuke Yagi, Kenya Kusunose, Hirotsugu Yamada, Takeshi Soeki, Michio Shimabukuro and Masataka Sata :
Rivaroxaban, a specific FXa inhibitor, improved endothelium-dependent relaxation of aortic segments in diabetic mice,
Scientific Reports, Vol.9, No.1, 11206, 2019.

(要約): Activated factor X (FXa) plays a central role in the coagulation cascade, while it also mediates vascular function through activation of protease-activated receptors (PARs). Here, we examined whether inhibition of FXa by rivaroxaban, a direct FXa inhibitor, attenuates endothelial dysfunction in streptozotocin (STZ)-induced diabetic mice. Induction of diabetes increased the expression of a major FXa receptor, PAR2, in the aorta (P < 0.05). Administration of rivaroxaban (10 mg/kg/day) to diabetic wild-type (WT) mice for 3 weeks attenuated endothelial dysfunction as determined by acetylcholine-dependent vasodilation compared with the control (P < 0.001), without alteration of blood glucose level. Rivaroxaban promoted eNOS phosphorylation in the aorta (P < 0.001). Induction of diabetes to PAR2-deficient (PAR2) mice did not affect endothelial function and eNOS phosphorylation in the aorta compared with non-diabetic PAR2 mice. FXa or a PAR2 agonist significantly impaired endothelial function in aortic rings obtained from WT mice, but not in those from PAR2 mice. FXa promoted JNK phosphorylation (P < 0.01) and reduced eNOS phosphorylation (P < 0.05) in human coronary artery endothelial cells (HCAEC). FXa-induced endothelial dysfunction in aortic rings (P < 0.001) and eNOS phosphorylation (P < 0.05) in HCAEC were partially ameliorated by a JNK inhibitor. Rivaroxaban ameliorated diabetes-induced endothelial dysfunction. Our results suggest that FXa or PAR2 is a potential therapeutic target.
(徳島大学機関リポジトリ): ● Metadata: 114192
(出版サイトへのリンク): ● Publication site (DOI): 10.1038/s41598-019-47474-0
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31371788; ● Search Scopus @ Elsevier (PMID): 31371788; ● Search Scopus @ Elsevier (DOI): 10.1038/s41598-019-47474-0

(徳島大学機関リポジトリ: 114192, DOI: 10.1038/s41598-019-47474-0, PubMed: 31371788) Yuta Torii, Kenya Kusunose, Hirotsugu Yamada, Susumu Nishio, Yukina Hirata, Amano Rie, Yamao Masami, Zheng Robert, Yoshihito Saijoh, nao Yamada, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Updated Left Ventricular Diastolic Function Recommendations and Cardiovascular Events in Patients with Heart Failure Hospitalization,
Journal of the American Society of Echocardiography, Vol.32, No.10, 1286-1297, 2019.

(要約): Evaluation of diastolic dysfunction is crucial in determining elevated left atrial pressure. However, a validation of the long-term prognostic value of the newly proposed algorithm updated in 2016 has not been performed. The aim of the present study was to investigate the relative value of the updated 2016 diastolic dysfunction grading system for the incidence of readmission in patients with heart failure (HF) with reduced ejection fraction (HFrEF) and HF with preserved ejection fraction (HFpEF). Two hundred thirty-two patients hospitalized with HF were retrospectively evaluated. Subjects were divided into two subgroups: those with HFrEF (n = 127) and those with HFpEF (n = 105). Readmission risk scores were calculated using the Yale Center for Outcomes Research and Evaluation HF, LACE index, and HOSPITAL scores. The primary end point was readmission following HF and cardiac death. Over a period of 24 months, 86 patients were either readmitted or died. Multivariate Cox analysis was performed on both the HFrEF and HFpEF groups. In the HFrEF group, both the 2009 and 2016 algorithms had superior incremental value for the association of the primary end point to several readmission risk scores. In the HFpEF group, only the 2016 algorithm led to significant improvement in association with the primary end point. The 2016 algorithm had incremental value over several readmission risk scores alone. The recommendations of the 2016 algorithm can be useful for readmission and cardiac mortality risk assessment in patients with HFrEF and HFpEF. The use of echocardiography to estimate elevated left atrial pressure appears to identify a higher risk group and may allow a more tailored approach to therapy.
(徳島大学機関リポジトリ): ● Metadata: 114193
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.echo.2019.06.006
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31378421; ● Summary page in Scopus @ Elsevier: 2-s2.0-85069976367

(徳島大学機関リポジトリ: 114193, DOI: 10.1016/j.echo.2019.06.006, PubMed: 31378421, Elsevier: Scopus) M Kajikawa, T Maruhashi, T Hidaka, S Matsui, H Hashimoto, Y Takaeko, Y Nakano, S Kurisu, Y Kihara, FM Yusoff, S Kishimoto, K Chayama, C Goto, K Noma, A Nakashima, T Hiro, A Hirayama, K Shiina, H Tomiyama, Shusuke Yagi, Amano Rie, Hirotsugu Yamada, Masataka Sata and Y Higashi :
Effect of Saxagliptin on Endothelial Function in Patients with Type 2 Diabetes: A Prospective Multicenter Study,
Scientific Reports, Vol.9, No.1, 10206, 2019.

(要約): The dipeptidyl peptidase-4 inhibitor saxagliptin is a widely used antihyperglycemic agent in patients with type 2 diabetes. The purpose of this study was to evaluate the effects of saxagliptin on endothelial function in patients with type 2 diabetes. This was a prospective, multicenter, interventional study. A total of 34 patients with type 2 diabetes were enrolled at four university hospitals in Japan. Treatment of patients was initially started with saxagliptin at a dose of 5 mg daily. Assessment of endothelial function assessed by flow-mediated vasodilation (FMD) and measurement of stromal cell-derived factor-1α (SDF-1α) were conducted at baseline and at 3 months after treatment with saxagliptin. A total of 31 patients with type 2 diabetes were included in the analysis. Saxagliptin significantly increased FMD from 3.1 ± 3.1% to 4.2 ± 2.4% (P = 0.032) and significantly decreased total cholesterol from 190 ± 24 mg/dL to 181 ± 25 mg/dL (P = 0.002), glucose from 160 ± 53 mg/dL to 133 ± 25 mg/dL (P < 0.001), HbA1c from 7.5 ± 0.6% to 7.0 ± 0.6% (P < 0.001), urine albumin-to-creatinine ratio from 63.8 ± 134.2 mg/g to 40.9 ± 83.0 mg/g (P = 0.043), and total SDF-1α from 2108 ± 243 pg/mL to 1284 ± 345 pg/mL (P < 0.001). These findings suggest that saxagliptin is effective for improving endothelial function.
(徳島大学機関リポジトリ): ● Metadata: 114195
(出版サイトへのリンク): ● Publication site (DOI): 10.1038/s41598-019-46726-3
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31308448; ● Summary page in Scopus @ Elsevier: 2-s2.0-85069056464

(徳島大学機関リポジトリ: 114195, DOI: 10.1038/s41598-019-46726-3, PubMed: 31308448, Elsevier: Scopus) Shusuke Yagi, Hiromu Yamazaki, Susumu Nishio, Kenya Kusunose, Hirotsugu Yamada and Masataka Sata :
Simultaneous Pulmonary Arterial and Venous Round Structures in Pulmonary Aspergillosis.,
Circulation Journal, Vol.83, No.6, 1416, 2019.

(徳島大学機関リポジトリ): ● Metadata: 113219
(出版サイトへのリンク): ● Publication site (DOI): 10.1253/circj.CJ-18-0898
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30393271; ● Summary page in Scopus @ Elsevier: 2-s2.0-85066748188

(徳島大学機関リポジトリ: 113219, DOI: 10.1253/circj.CJ-18-0898, PubMed: 30393271, Elsevier: Scopus) Daiju Fukuda, Sachiko Nishimoto, Kunduziayi Aini, Atsushi Tanaka, Tsuyoshi Nishiguchi, Joo-Ri Kim-Kaneyama, Xiao-Feng Lei, Kiyoshi Masuda, Takuya Naruto, Kimie Tanaka, Yasutomi Higashikuni, Yoichiro Hirata, Shusuke Yagi, Kenya Kusunose, Hirotsugu Yamada, Takeshi Soeki, Issei Imoto, Takashi Akasaka, Michio Shimabukuro and Masataka Sata :
Toll-Like Receptor 9 Plays a Pivotal Role in Angiotensin II-Induced Atherosclerosis,
Journal of the American Heart Association, Vol.8, No.7, e010860, 2019.

(要約): Background Toll-like receptor ( TLR ) 9 recognizes bacterial DNA , activating innate immunity, whereas it also provokes inflammation in response to fragmented DNA released from mammalian cells. We investigated whether TLR 9 contributes to the development of vascular inflammation and atherogenesis using apolipoprotein E-deficient ( Apoe ) mice. Methods and Results Tlr9-deficient Apoe ( Tlr9 Apoe ) mice and Apoe mice on a Western-type diet received subcutaneous angiotensin II infusion (1000 ng/kg per minute) for 28 days. Angiotensin II increased the plasma level of double-stranded DNA, an endogenous ligand of TLR 9, in these mice. Genetic deletion or pharmacologic blockade of TLR 9 in angiotensin II-infused Apoe mice attenuated atherogenesis in the aortic arch ( P<0.05), reduced the accumulation of lipid and macrophages in atherosclerotic plaques, and decreased RNA expression of inflammatory molecules in the aorta with no alteration of metabolic parameters. On the other hand, restoration of TLR 9 in bone marrow in Tlr9 Apoe mice promoted atherogenesis in the aortic arch ( P<0.05). A TLR 9 agonist markedly promoted proinflammatory activation of Apoe macrophages, partially through p38 mitogen-activated protein kinase signaling. In addition, genomic DNA extracted from macrophages promoted inflammatory molecule expression more effectively in Apoe macrophages than in Tlr9 Apoe macrophages. Furthermore, in humans, circulating double-stranded DNA in the coronary artery positively correlated with inflammatory features of coronary plaques determined by optical coherence tomography in patients with acute myocardial infarction ( P<0.05). Conclusions TLR 9 plays a pivotal role in the development of vascular inflammation and atherogenesis through proinflammatory activation of macrophages. TLR 9 may serve as a potential therapeutic target for atherosclerosis.
(キーワード): Aged / Angiotensin II / Animals / Aorta, Thoracic / 動脈硬化 (atherosclerosis) / Bone Marrow Transplantation / Cell-Free Nucleic Acids / Chemokine CCL2 / 女性 (female) / Humans / In Vitro Techniques / 炎症 (inflammation) / Lipids / Macrophages / Macrophages, Peritoneal / 男性 (male) / Mice / ノックアウトマウス (knockout mice) / Mice, Knockout, ApoE / Microscopy, Electron / Myocardial Infarction / Percutaneous Coronary Intervention / Plaque, Atherosclerotic / RNA, Messenger / Reverse Transcriptase Polymerase Chain Reaction / Toll-Like Receptor 9 / Tomography, Optical Coherence / Tumor Necrosis Factor-alpha / Vasoconstrictor Agents
(徳島大学機関リポジトリ): ● Metadata: 113231
(出版サイトへのリンク): ● Publication site (DOI): 10.1161/JAHA.118.010860
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30905257; ● Summary page in Scopus @ Elsevier: 2-s2.0-85063712345

(徳島大学機関リポジトリ: 113231, DOI: 10.1161/JAHA.118.010860, PubMed: 30905257, Elsevier: Scopus) Yukina Hirata, Kenya Kusunose, Hirotsugu Yamada, Sae Morita, Yuta Torii, Susumu Nishio, Robert Zheng, Yoshihito Saijo, Daiju Fukuda, Shusuke Yagi, Takeshi Soeki and Masataka Sata :
Left atrial functional response after a marathon in healthy amateur volunteers,
The International Journal of Cardiovascular Imaging, Vol.35, No.4, 633-643, 2019.

(要約): Middle-aged marathon runners have an increased risk of developing atrial fibrillation (AF). A previous study described that repetitive marathon running was associated with left atrial (LA) dysfunction. However, whether this change is common in marathon runners and which runners are at risk of LA dysfunction remain unknown. The purpose of this study was to determine which factors could predict LA dysfunction. We prospectively examined 12 healthy amateur volunteers (9 males, 31 ± 8 years old) who participated in a full marathon. All echocardiographic measurements and speckle-tracking echocardiography were performed before and after the marathon. The endpoint was defined as reduced LA reservoir strain 1 day after the marathon (non-responder group). Seven participants were in the non-responder group. Age (35 ± 9 vs. 26 ± 2 years, p = 0.020), augmentation index (76 ± 12 vs. 55 ± 8, p = 0.002), and diastolic blood pressures (83 ± 11 vs. 70 ± 7 mmHg, p = 0.021) in the non-responder group were significantly higher compared with the responder group. In multivariate linear regression analysis, only the augmentation index was an independent predictor of reduced LA reservoir function after the marathon (β = - 0.646, p = 0.023). The augmentation index was a predictive marker for reduction in LA reservoir function after a marathon in healthy amateur volunteers.
(キーワード): Adaptation, Physiological / Adult / Atrial Fibrillation / Atrial Function, Left / Atrial Remodeling / Echocardiography, Doppler / 女性 (female) / Healthy Volunteers / Humans / 男性 (male) / Middle Aged / Physical Endurance / Prospective Studies / Risk Factors / Running / Time Factors / Young Adult
(徳島大学機関リポジトリ): ● Metadata: 113069
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s10554-018-1502-2
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30470971; ● Summary page in Scopus @ Elsevier: 2-s2.0-85057125051

(徳島大学機関リポジトリ: 113069, DOI: 10.1007/s10554-018-1502-2, PubMed: 30470971, Elsevier: Scopus) Shusuke Yagi, Daisuke Kondo, Takayuki Ise, Daiju Fukuda, Koji Yamaguchi, Tetsuzo Wakatsuki, Yutaka Kawabata, Hiroyuki Ito, Yoshihito Saijo, Hiromitsu Seno, Kumiko Sutou, Rie Ueno, Takafumi Todoroki, Kenya Kusunose, Tomomi Matsuura, Takeshi Tobiume, Hirotsugu Yamada, Takeshi Soeki, Michio Shimabukuro, Ken-ichi Aihara, Masashi Akaike and Masataka Sata :
Association of Decreased Docosahexaenoic Acid Level After Statin Therapy and Low Eicosapentaenoic Acid Level with In-Stent Restenosis in Patients with Acute Coronary Syndrome,
Journal of Atherosclerosis and Thrombosis, Vol.26, No.3, 272-281, 2019.

(要約): It is speculated that statin therapy modulates the synthesis of polyunsaturated fatty acids (PUFA), including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). However, the data available on the effects of statin therapy on the serum levels of PUFA and the subsequent impact on in-stent restenosis (ISR) in patients with acute coronary syndrome (ACS) are limited. A total of 120 ACS patients who received emergent coronary stent implantation, follow-up coronary angiography to evaluate ISR, and new statin therapy were enrolled. We measured the serum levels of the PUFA and lipids at the onset of ACS and at the follow-up coronary angiography. The follow-up coronary angiography revealed 38 ISR cases. New statin therapy significantly reduced the serum levels of DHA and low-density lipoprotein cholesterol (LDL-C), while it did not affect EPA level. Single regression analysis revealed that a decreased serum level of LDL-C was associated with decreased DHA level. The multiple logistic regression analysis revealed that the decreased DHA level after statin therapy and low serum level of EPA on admission were determinants of prevalence of ISR. Statin therapy decreased the serum level of DHA with a parallel reduction in LDL-C level in patients with ACS. Decreased DHA level after statin therapy and low EPA level on admission are risk factors for ISR, indicating that in patients with ACS, decreased serum levels of DHA may be a residual target for the prevention of ISR.
(キーワード): Acute Coronary Syndrome / Aged / Coronary Restenosis / Docosahexaenoic Acids / Eicosapentaenoic Acid / 女性 (female) / Follow-Up Studies / Humans / Hydroxymethylglutaryl-CoA Reductase Inhibitors / 男性 (male) / Prognosis / Retrospective Studies / Risk Factors / Stents
(徳島大学機関リポジトリ): ● Metadata: 113220
(出版サイトへのリンク): ● Publication site (DOI): 10.5551/jat.44735
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30135329; ● Summary page in Scopus @ Elsevier: 2-s2.0-85062425735

(徳島大学機関リポジトリ: 113220, DOI: 10.5551/jat.44735, PubMed: 30135329, Elsevier: Scopus) Yuko Saito, Hirotsugu Yamada, Kenya Kusunose, Ken Saito and Masataka Sata :
Noninvasive assessment of left-ventricular diastolic electromechanical coupling in hypertensive heart disease,,
Journal of Echocardiography, Vol.17, No.4, 206-212, 2019.

(要約): There is a need to stratify patients who may develop heart failure because of the current "heart failure pandemic". We hypothesized that noninvasive assessment of diastolic electromechanical coupling by electrocardiography and Doppler echocardiography may be clinically useful for risk stratification of hypertensive patients who may develop heart failure. We measured the time from the peak to end of the T wave (TpTe) as an electrophysiological parameter, and peak early diastolic mitral flow (E) and lateral annular (e') velocities as mechanical parameters in 109 patients with hypertension. Relationships between these parameters and their association with the prognosis were evaluated. The e' was inversely correlated with TpTe (p < 0.001) and QTc (p < 0.014), whereas E/e' was positively correlated with TpTe (p < 0.001) and QTc (p < 0.001). The TpTe predicted patients with E/e' > 12. There were 24 cardiovascular events during follow-up (57 ± 20 months), and Kaplan-Meier analysis showed that outcome was worse (p = 0.003) in patients with higher E/e' than lower E/e'; however, there was no difference between patients with longer TpTe (≧72 ms) and shorter TpTe (< 72 ms). The correlation of TpTe with e' and E/e' in hypertensive patients suggests that these parameters reflect diastolic ventricular electromechanical coupling. The E/e' predicted outcome, and an elevated E/e' should be suspected when TpTe is prolonged (> 72 ms). Noninvasive evaluation of diastolic electromechanical coupling is clinically useful in patients with hypertension for predicting their outcome.
(徳島大学機関リポジトリ): ● Metadata: 113350
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s12574-019-00421-4
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30756346; ● Summary page in Scopus @ Elsevier: 2-s2.0-85061449967

(徳島大学機関リポジトリ: 113350, DOI: 10.1007/s12574-019-00421-4, PubMed: 30756346, Elsevier: Scopus) Atsuko Yoshida, Takashi Kaji, Hirotsugu Yamada, Naoto Yonetani, Eishi Sogawa, Masami Yamao, Kazuhisa Maeda, Masataka Sata and Minoru Irahara :
Measurement of hemodynamics immediately after vaginal delivery in healthy pregnant women by electrical cardiometry.,
The Journal of Medical Investigation : JMI, Vol.66, No.1.2, 75-80, 2019.

(要約): Few reports have focused on hemodynamics around delivery in pregnant women because of the difficulty of continuous and noninvasive measurement. Electrical cardiometry allows noninvasive continuous monitoring of hemodynamics and has recently been used in non-pregnant subjects. We compared the use of electrical cardiometry versus transthoracic echocardiography in healthy pregnant women and evaluated hemodynamics immediately after vaginal delivery. In Study 1, electrical cardiometry and transthoracic echocardiography were used to measure cardiac output in 20 pregnant women with threatened premature delivery. A significant correlation was found between the two methods, with electrical cardiometry showing the higher cardiac output. In Study 2, heart rate, stroke volume, and cardiac output were continuously measured in 15 women during vaginal delivery up to 2 h postpartum. Cardiac output increased markedly because of an increased heart rate and stroke volume at the time of newborn delivery. The heart rate then immediately returned to baseline, while cardiac output remained elevated for at least 2 h after delivery because of a sustained high stroke volume. Electrical cardiometry was as readily available as transthoracic echocardiography for evaluating hemodynamics and allowed for continuous measurement during labor. High intrapartum cardiac output was sustained for at least 2 h after vaginal delivery. J. Med. Invest. 66 : 75-80, February, 2019.
(徳島大学機関リポジトリ): ● Metadata: 113325
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.66.75
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31064959; ● Search Scopus @ Elsevier (PMID): 31064959; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.66.75

(徳島大学機関リポジトリ: 113325, DOI: 10.2152/jmi.66.75, PubMed: 31064959) 高橋未奈, 飛梅威, 松本和久, 松浦朋美, 添木武, 藤本裕太, 原田貴文, Zheng Robert, 數藤久美子, 西條良仁, 上野理絵, 川端豊, 坂東美佳, 山田なお, 伊藤浩敬, 轟貴史, 伊勢孝之, 楠瀬賢也, 山口浩司, 八木秀介, 福田大受, 山田博胤, 若槻哲三, 佐田政隆 :
大動脈弁人工弁(機械弁)置換術後遠隔期に生じたOMI-VT stormに対し経心房中隔的に施行したカテーテルアブレーションが著効した1例,
四国医学雑誌, Vol.74, No.56, 201-208, 2019年.

(要約): A 68-year-old woman with VT storm and frequent appropriate ICD therapy was referred for catheter ablation. Her past history was notable for aortic valve replacement by mechanical valve due to infectious endocarditis 17 years prior to presentation and left ventricular apical old myocardial infarction with unknown onset. At 67 years old, She admitted to the prior hospital due to ventricular tachycardia with LBBB and superior axis at heart rate of 210 per minutes. Administration of amiodarone and magnesium sulfate was ineffective and cardioversion of 200J was successfully terminated the tachycardia. Intra-cardiac defibrillator was implanted and the administration of amiodarone and mexiletine was started. 5 months after, she admitted to the hospital due to the frequent appropriate shock against the same ventricular tachycardia. Administration of lidocaine, sotalol, pilsicainide, and magnesium sulfate could not control the tachycardia and she was referred to our hospital for catheter ablation. During the first session, ventricular tachycardia was easily induced and electroanatomical mapping was performed both during tachycardia and during sinus rhythm. Late diastolic potential preceding the onset of QRS wave by 45ms was detected at the infero-septal side of the apical aneurysm. 7 5s of the RF energy application at this site could terminate the tachycardia and thereafter no ventricular tachycardia was induced. But after dose-reduction or cessation of some anti-arrhythmic drugs, ventricular tachycardia was recurred and second session was performed. This time, no ventricular tachycardia was induced, then we performed isthmus transection and core isolation against the apical aneurysm. Thereafter no ventricular tachycardia was occurred in spite of dose-reduction or cessation of some anti-arrhythmic drugs.
(キーワード): ventricular tachycardia / storm / old myocardial infarction / catheter ablation / aortic valve replacement
(徳島大学機関リポジトリ): ● Metadata: 112988
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1050020697876465664

(徳島大学機関リポジトリ: 112988, CiNii: 1050020697876465664) 平田有紀奈, 西尾進, 原田修, 宮里尚美, 原國督, 楠瀬賢也, 伊藤敦彦, 山田博胤, 佐田政隆 :
超音波検査を用いた心外膜下脂肪厚の検査者間誤差の検討,
超音波検査技術, Vol.44, No.4, 456-463, 2019年.

(出版サイトへのリンク): ● Publication site (DOI): 10.11272/jss.290
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390845713087095296; ● Search Scopus @ Elsevier (DOI): 10.11272/jss.290

(DOI: 10.11272/jss.290, CiNii: 1390845713087095296) 松本力三, 西尾進, 平田有紀奈, 湯浅麻美, 鳥居裕太, 天野里江, 山尾雅美, 荒瀬美晴, 楠瀬賢也, 山田博胤, 佐田政隆 :
糖尿病性腎症の各病期における超音波指標の比較,
超音波検査技術, Vol.44, No.4, 447-455, 2019年.

(出版サイトへのリンク): ● Publication site (DOI): 10.11272/jss.288
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390845713087255168; ● Search Scopus @ Elsevier (DOI): 10.11272/jss.288

(DOI: 10.11272/jss.288, CiNii: 1390845713087255168) Shusuke Yagi, Robert Zheng, Seiichi Nishiyama, Yutaka Kawabata, Takayuki Ise, Kosuke Sugiura, Haruhiko Yoshinari, Toshihiko Nishisho, Yoshimi Bando, Kumiko Kagawa, Daiju Fukuda, Tomohiro Soga, Yoshihito Saijoh, Kenya Kusunose, Koji Yamaguchi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Shinji Kawahito, Masashi Akaike and Masataka Sata :
Osteolytic primary bone lymphoma in the multiple bones,
The Journal of Medical Investigation : JMI, Vol.66, No.3,4, 347-350, 2019.

(要約): Primary non-Hodgkin bone lymphoma (PBL) can involve solitary or multiple destructive bone lesions such as those of the femur or pelvis humerus, and some cases have osteolytic lesions. PBL is a rare disease in adults. Thus, PBL is rarely considered a differential diagnosis of the osteolytic tumor. In addition, PBL can be underdiagnosed because patients do not experience symptoms or show objective abnormalities in the early stage. Here, we reported an elderly patient with PBL in multiple bones, including the cranial and femoral bones that were fractured due to falling. J. Med. Invest. 66 : 347-350, August, 2019.
(徳島大学機関リポジトリ): ● Metadata: 114167
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.66.347
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31656303; ● Summary page in Scopus @ Elsevier: 2-s2.0-85074142443

(徳島大学機関リポジトリ: 114167, DOI: 10.2152/jmi.66.347, PubMed: 31656303, Elsevier: Scopus) Shusuke Yagi, Itsuro Endo, Taichi Murakami, Tetsuya Hida, Yousuke Yamamoto, Tomohiro Soga, Takayuki Ise, Kenya Kusunose, Koji Yamaguchi, Daiju Fukuda, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Shinji Kawahito and Masataka Sata :
Adult onset of Immunoglobulin A vasculitis - A case report,,
The Journal of Medical Investigation : JMI, Vol.66, No.3,4, 344-346, 2019.

(要約): Immunoglobulin A vasculitis (IgAV), formerly known as Henoch-Schönlein purpura, primarily occurs during childhood between the ages of 3 and 15 years and is the most common form of systemic vasculitis in children ; its occurrence in adults has been rarely reported. Such low incidence could be attributable to either under-diagnosis or misdiagnosis. Thus, not only pediatricians but also physicians should be able to diagnose IgAV accurately to manage the patients appropriately and avoid its associated complications. In addition, treatment of adult onset IgAV with renal involvement has not been fully established yet. We describe here a case of adult onset IgAV complicated by proteinuria and pharyngitis, which was cured by no specific treatment. J. Med. Invest. 66 : 344-346, August, 2019.
(キーワード): Acetaminophen / Adult / Factor XIII / Humans / Immunoglobulin A / Male / Pharyngitis / Proteinuria / Purpura, Schoenlein-Henoch
(徳島大学機関リポジトリ): ● Metadata: 114166
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.66.344
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31656302; ● Search Scopus @ Elsevier (PMID): 31656302; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.66.344

(徳島大学機関リポジトリ: 114166, DOI: 10.2152/jmi.66.344, PubMed: 31656302) 山田博胤, 坂東美佳 :
循環器領域のPOCUS : 現状, 問題点と将来展望,
超音波医学, Vol.46, No.1, 17-24, 2019年.

(要約): 心臓に対する超音波の臨床応用には約70年の歴史があるが，その大きな転換期は，バッテリーで駆動する小型の携帯型超音波診断装置の登場である．これにより，心エコー図検査を行う場所が検査室外に大きく広がっただけでなく，それまではそれを専門の生業とする医師や技師が行う検査であったのが，救急医や麻酔科医，プライマリケア医など心エコーを専門としない医師が心エコー図検査を利用するようになった．そして，このような目の前の患者に対して，医師が病態の評価やマネージメントあるいは処置のガイドのために行う超音波検査をPoint-of-Care 超音波(POCUS)と呼ぶようになった．POCUSの心エコー図検査は，救急医や麻酔科医など心エコーの非専門家がプロトコールに即して施行するfocused cardiac ultrasound examination(FoCUS)と，系統的心エコー図検査の高度な知識と技術を有する循環器内科医がベッドサイドで行うlimited echocardiographyに大別される．FoCUSは，そのプロトコールや評価法がほぼ確立され，その効果を証明するエビデンスも蓄積されつつある．本邦においても普及しつつあるが，教育システムが確立されているとはいえず，医学生や研修医に対する教育をどうするかについても，今後議論が必要であろう．循環器分野のPOCUSが広く普及しても，聴診が不要になるということはない．むしろ，身体診察の流れの中で視診，触診，聴診に加えて，エコー診を加えることが，患者にとって大きな恩恵をもたらすことになるだろう．
(キーワード): focused cardiac ultrasound / limited echocardiography / portable ultrasound diagnostic machine / education / point-of-care ultrasound
(出版サイトへのリンク): ● Publication site (DOI): 10.3179/jjmu.JJMU.R.148
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390564238064127232; ● Search Scopus @ Elsevier (DOI): 10.3179/jjmu.JJMU.R.148

(DOI: 10.3179/jjmu.JJMU.R.148, CiNii: 1390564238064127232) Shusuke Yagi, Rie Ueno, Kumiko Sutou, Tetsuzo Wakatsuki, Koji Yamaguchi, Yoshihito Saijo, Tomoya Hara, Takayuki Ise, Kenya Kusunose, Mika Bando, Tomomi Matsuura, Takeshi Tobiume, Hirotsugu Yamada, Daiju Fukuda, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Lambda-like J wave due to acute myocardial infarction of the diagonal branch,
The Journal of Medical Investigation : JMI, Vol.66, No.1,2, 185-187, 2019.

(要約): The culprit lesion of acute myocardial infarction could be predicted by electrocardiogram findings. However, we experienced some cases with coronary angiographic finding in the area of ST-T elevation that was different from that predicted. The lambda-like J wave could be caused by ischemia although the mechanism has not been fully elucidated. We report a case of acute myocardial infarction that showed discrepancy between ST-T elevation with lambda-like ischemic J wave in a broad area and coronary angiographical finding of diagonal branch occlusion. J. Med. Invest. 66 : 185-187, February, 2019.
(徳島大学機関リポジトリ): ● Metadata: 113420
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.66.185
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31064936; ● Summary page in Scopus @ Elsevier: 2-s2.0-85065772885

(徳島大学機関リポジトリ: 113420, DOI: 10.2152/jmi.66.185, PubMed: 31064936, Elsevier: Scopus) Yuishin Izumi, Ryosuke Miyamoto, Koji Fujita, Yuki Yamamoto, Hirotsugu Yamada, Tomoyasu Matsubara, Yuki Unai, Ai Tsukamoto, Naoko Takamatsu, Hiroyuki Nodera, Shinya Hayashi, Masaya Oda, Atsuko Mori, Yoshihiko Nishida, Shunsuke Watanabe, Hirohisa Ogawa, Hisanori Uehara, Shigeo Murayama, Masataka Sata and Ryuji Kaji :
Distinct Incidence of Takotsubo Syndrome Between Amyotrophic Lateral Sclerosis and Synucleinopathies: A Cohort Study.,
Frontiers in Neurology, Vol.9, 1099, 2018.

(要約): Takotsubo syndrome (TTS) is an acute cardiac syndrome characterized by regional left ventricular dysfunction with a peculiar circumferential pattern, which typically results in apical ballooning. Evidence indicates a pivotal role of catecholamines in TTS, and researchers have discussed multiple hypotheses on the etiology, including multivessel coronary spasm, myocardial stunning, excessive transient ventricular afterload, and cardiac sympathetic overactivity with local noradrenaline spillover. Although central nervous system disorders, such as stroke and epilepsy, are known to trigger TTS, the incidence and clinical features of TTS in neurodegenerative disorders are poorly understood. Here, we retrospectively examined TTS cases in a single-center cohort composed of 250 patients with amyotrophic lateral sclerosis (ALS) and 870 patients with synucleinopathies [582 patients with Parkinson's disease (PD), 125 patients with dementia with Lewy bodies (DLB), and 163 patients with multiple system atrophy (MSA)] and identified 4 (1.6%, including 2 women) cases with ALS and no cases with synucleinopathies. Two ALS patients underwent autopsy and the pathological findings were compatible with the chronological changes identified in catecholamine-induced cardiomyopathy. A literature review identified 16 TTS cases with ALS, 1 case each with PD and DLB, and no cases with MSA. When current and previous TTS cases with ALS were concatenated: 55% (11/20) were female; 35% (7/20) had a bulbar-onset and 45% (9/20) had a limb-onset; the mean age of TTS onset was 63.3 ± 9.0 years and the mean interval time from ALS onset to TTS development was 4.9 ± 3.0 years; no (0/16) patients developed TTS within 12 months after ALS onset; 50% (10/20) underwent artificial ventilations; the mortality was 17% (3/18); and most cases had precipitating factors, and TTS development was associated with gastrostomy, tracheostomy, or infections in 45% (9/20) of the patients. This study demonstrated that ALS is a considerable predisposing factor of TTS and that synucleinopathies rarely cause TTS. The distinct TTS incidence between ALS and synucleinopathies may be due to cardiac sympathetic overactivity in ALS and may also be affected by cardiac sympathetic denervation in synucleinopathies. Moreover, the etiology of TTS in ALS may be reasonably explained by the two-hit theory.
(徳島大学機関リポジトリ): ● Metadata: 113228
(出版サイトへのリンク): ● Publication site (DOI): 10.3389/fneur.2018.01099
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30619056; ● Search Scopus @ Elsevier (PMID): 30619056; ● Search Scopus @ Elsevier (DOI): 10.3389/fneur.2018.01099

(徳島大学機関リポジトリ: 113228, DOI: 10.3389/fneur.2018.01099, PubMed: 30619056) Sachiko Nishimoto, Kunduziayi Aini, Daiju Fukuda, Yasutomi Higashikuni, Kimie Tanaka, Yoichiro Hirata, Shusuke Yagi, Kenya Kusunose, Hirotsugu Yamada, Takeshi Soeki, Michio Shimabukuro and Masataka Sata :
Activation of Toll-Like Receptor 9 Impairs Blood Flow Recovery After Hind-Limb Ischemia,
Frontiers in Cardiovascular Medicine, Vol.5, 144, 2018.

(要約): Peripheral artery disease causes significant functional disability and results in impaired quality of life. Ischemic tissue injury releases various endogenous ligands for Toll-like receptors (TLRs), suggesting the involvement of TLRs in blood flow recovery. However, the role of TLR9, which was originally known as a sensor for bacterial DNA, remains unknown. This study investigated the role of TLR9 in blood flow recovery in the ischemic limb using a mouse hind-limb ischemia model. Unilateral femoral artery ligation was performed in TLR9-deficient () mice and wild-type mice. In wild-type mice, femoral artery ligation significantly increased mRNA expression of TLR9 in the ischemic limb ( < 0.001) and plasma levels of cell-free DNA (cfDNA) as determined by single-stranded DNA (ssDNA) ( < 0.05) and double-stranded DNA (dsDNA) ( < 0.01), which are endogenous ligands for TLR9, compared with the sham-operated group. Laser Doppler perfusion imaging demonstrated significantly improved ratio of blood flow in the ischemic to non-ischemic limb in mice compared with wild-type mice at 2 weeks after ligation ( < 0.05). mice showed increased capillary density and reduced macrophage infiltration in ischemic limb. Genetic deletion of TLR9 reduced the expression of TNF-α, and attenuated NF-κB activation in ischemic muscle compared with wild-type mice ( < 0.05, respectively) at 3 days after the surgery. ODN1826, a synthetic agonistic oligonucleotide for TLR9, or plasma obtained from mice with ischemic muscle promoted the expression of TNF-α in wild-type macrophages ( < 0.05), but not in macrophages. ODN1826 also activated NF-κB signaling as determined by the degradation of IκBα in wild-type macrophages ( < 0.05), but not in macrophages. In vitro experiments using human umbilical vein endothelial cells demonstrated that TNF-α, or conditioned medium obtained from wild-type macrophages treated with ODN1826 accelerated cell death as determined by MTS assay ( < 0.05 and < 0.01, respectively). Our results suggest that ischemic muscle releases cfDNA, which activates TLR9 and enhances inflammation, leading to impairment of blood flow recovery in the ischemic limb. cfDNA-TLR9 signaling may serve as a potential therapeutic target in ischemic limb disease.
(徳島大学機関リポジトリ): ● Metadata: 113226
(出版サイトへのリンク): ● Publication site (DOI): 10.3389/fcvm.2018.00144
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30460242; ● Search Scopus @ Elsevier (PMID): 30460242; ● Search Scopus @ Elsevier (DOI): 10.3389/fcvm.2018.00144

(徳島大学機関リポジトリ: 113226, DOI: 10.3389/fcvm.2018.00144, PubMed: 30460242) Yukina Hirata, Hirotsugu Yamada and Masataka Sata :
Epicardial Fat and Pericardial Fat Surrounding the Heart Have Different Characteristics.,
Circulation Journal, Vol.82, No.10, 2475-2476, 2018.

(徳島大学機関リポジトリ): ● Metadata: 114199
(出版サイトへのリンク): ● Publication site (DOI): 10.1253/circj.CJ-18-0923
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30185691; ● Summary page in Scopus @ Elsevier: 2-s2.0-85054095916

(徳島大学機関リポジトリ: 114199, DOI: 10.1253/circj.CJ-18-0923, PubMed: 30185691, Elsevier: Scopus) Yoshihito Saijo, Hirotsugu Yamada, Kenya Kusunose, Mika Bando, Susumu Nishio, Yuta Torii, Yukina Hirata, Hiromitsu Seno, Tomomi Matsuura, Takayuki Ise, Takeshi Tobiume, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
A clinical application of preload stress echocardiography for predicting future hemodynamic worsening in patients with early-stage heart failure.,
Echocardiography, Vol.35, No.10, 1587-1595, 2018.

(要約): To improve the prognosis of patients with heart failure, risk stratification in their early stage is important. We assessed whether the change in transmitral flow (TMF) velocity pattern during preload augmentation can predict future hemodynamic worsening in early-stage heart failure patients with impaired relaxation TMF pattern. We designed a prospective cohort study that included 155 consecutive patients with impaired relaxation (IR) pattern at rest. Preload stress echocardiography was achieved using leg-positive pressure (LPP), and changes in TMF pattern during the LPP was observed during baseline echocardiographic examination. The patients whose TMF pattern developed to pseudonormal (PN) pattern throughout the study period were classified into the change to PN group, and patients whose TMF pattern stayed in IR pattern were classified into the stay in IR group. The median follow-up period was 17 months. The average age was 68 ± 11 years old, and 97 patients (63%) were male. Among 155 patients, 27 were classified into the change to PN group. A Cox proportional hazard analysis confirmed that the change in the peak atrial systolic TMF velocity during the LPP (ΔA, hazard ratio = 0.58 per 1SD; 95% CI = 0.39-0.88, P = 0.010) was the powerful independent predictor of change into PN pattern. Kaplan-Meier analysis revealed that the patients with ΔA -7 cm/s had more likely to develop into PN pattern than patients with ΔA > -7 cm/s (P = 0.001). Evaluation of a response in TMF during the LPP might provide an incremental diagnostic value to detect future overt heart failure in patients with early-stage heart failure.
(徳島大学機関リポジトリ): ● Metadata: 112877
(出版サイトへのリンク): ● Publication site (DOI): 10.1111/echo.14098
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30005132; ● Summary page in Scopus @ Elsevier: 2-s2.0-85054773574

(徳島大学機関リポジトリ: 112877, DOI: 10.1111/echo.14098, PubMed: 30005132, Elsevier: Scopus) Kenya Kusunose, Hiromitsu Seno, Hirotsugu Yamada, Susumu Nishio, Yuta Torii, Yukina Hirata, Y Saijo, Takayuki Ise, Koji Yamaguchi, Daiju Fukuda, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Right Ventricular Function and Beneficial Effects of Cardiac Rehabilitation in Patients With Systolic Chronic Heart Failure.,
The Canadian Journal of Cardiology, Vol.34, No.10, 1307-1315, 2018.

(要約): It has been recognized that a comprehensive cardiac rehabilitation (CR) program improves mortality in patients with chronic heart failure. On the other hand, the magnitude of the improvement in exercise capacity after CR differs among individuals. The aim of this study was to assess the echocardiographic determinants of responders to CR using preload stress echocardiography. We prospectively enrolled 58 chronic heart failure patients with reduced left ventricular ejection fraction (aged 62 ± 11 years; 69% male; left ventricular ejection fraction 43% ± 7%) who had received optimized medical treatment in a CR program for 5 months. We performed preload echocardiographic studies using leg positive pressure (LPP) to assess the echocardiographic parameters during preload augmentation. We defined 41 patients as a development cohort to assess the predictive value of echocardiographic variables. Next, we validated results in the remaining 17 patients as a validation cohort. In the development cohort, significant improvement in peak oxygen uptake (VO) (>10%) after CR was observed in 58% patients. In a multivariable logistic regression model, the significant predictor of improvement in exercise capacity was right ventricular (RV) strain during LPP (odds ratio: 3.96 per 1 standard deviation; P = 0.01). An RV strain value of -16% during LPP had a good sensitivity of 0.79 and a specificity of 0.71 to identify patients with improvement in peak VO. In the validation cohort, an optimal cutoff value of RV strain value was the same (area under the curve: 0.77, sensitivity: 0.78, specificity: 0.65). RV strain during LPP may be an echocardiographic parameter for assessing beneficial effects of CR.
(徳島大学機関リポジトリ): ● Metadata: 114204
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.cjca.2018.06.003
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30146462; ● Summary page in Scopus @ Elsevier: 2-s2.0-85052061274

(徳島大学機関リポジトリ: 114204, DOI: 10.1016/j.cjca.2018.06.003, PubMed: 30146462, Elsevier: Scopus) Takeshi Soeki, Tomomi Matsuura, Takeshi Tobiume, Sachiko Bando, Matsumoto Kazuhisa, Hiromi Nagano, Etsuko Uematsu, Kenya Kusunose, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Clinical, Electrocardiographic, and Echocardiographic Parameter Combination Predicts the Onset of Atrial Fibrillation.,
Circulation Journal, Vol.82, No.9, 2253-2258, 2018.

(要約): The ability to identify risk markers for new-onset atrial fibrillation (AF) is critical to the development of preventive strategies, but it remains unknown whether a combination of clinical, electrocardiographic, and echocardiographic parameters predicts the onset of AF. In the present study, we evaluated the predictive value of a combined score that includes these parameters.Methods and Results:We retrospectively studied 1,040 patients without AF who underwent both echocardiography and 24-h Holter electrocardiography between May 2005 and December 2010. During a median follow-up period of 68.4 months (IQR, 49.9-93.3 months), we investigated the incidence of new-onset AF. Of the 1,040 patients, 103 (9.9%) developed AF. Patients who developed AF were older than patients who did not. Total heart beats, premature atrial contraction (PAC) count, maximum RR interval, and frequency of sinus pause quantified on 24-h electrocardiography were associated with new-onset AF. LA diameter (LAD) on echocardiography was also associated with the development of AF. On multivariate Cox analysis, age 58 years, PAC count 80 beats/day, maximum RR interval 1.64 s, and LAD 4.5 cm were independently associated with the development of AF. The incidence rate of new-onset AF significantly increased as the combined score (i.e., the sum of the risk score determined using hazard ratios) increased. A combined score that includes age, PAC count, maximum RR interval, and LAD could help characterize the risk of new-onset AF.
(徳島大学機関リポジトリ): ● Metadata: 113221
(出版サイトへのリンク): ● Publication site (DOI): 10.1253/circj.CJ-17-0758
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29848884; ● Summary page in Scopus @ Elsevier: 2-s2.0-85052204332

(徳島大学機関リポジトリ: 113221, DOI: 10.1253/circj.CJ-17-0758, PubMed: 29848884, Elsevier: Scopus) Kageyuki Oba, Minetaka Maeda, Gulinu Maimaituxun, Satoshi Yamaguchi, Osamu Arasaki, Daiju Fukuda, Shusuke Yagi, Hirata Yukina, Susumu Nishio, Takashi Iwase, Shoichiro Takao, Kenya Kusunose, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Masafumi Harada, Hiroaki Masuzaki, Masataka Sata and Michio Shimabukuro :
Effect of the Epicardial Adipose Tissue Volume on the Prevalence of Paroxysmal and Persistent Atrial Fibrillation.,
Circulation Journal, Vol.82, No.7, 1778-1787, 2018.

(要約): Although increasing evidence suggests that epicardial adipose tissue volume (EATV) is associated with atrial fibrillation (AF), it is controversial whether there is a dose-response relationship of increasing EATV along the continuum of AF. We evaluated the effect of the EATV on the prevalence of paroxysmal AF (PAF) and persistent AF (PeAF) and the relationships with cardiac structure and functional remodeling.Methods and Results:Subjects who underwent multidetector computed tomography (MDCT) coronary angiography because of symptoms suggestive of coronary artery disease were divided into sinus rhythm (SR) (n=112), PAF (n=133), and PeAF (n=71) groups. The EATV index (EATV/body surface area, mL/m) was strongly associated with the prevalence of PAF and PeAF on the model adjusted for known AF risk factors. The effect of the EATV index on the prevalence of PeAF, but not on that of PAF, was modified by the left atrial (LA) dimension, suggesting that extension of the LA dimension is related to EATV expansion in PeAF. The cutoff value of the EATV index for the prevalence was higher in PeAF than in PAF (64 vs. 55 mL/m, P<0.01). The EATV index is associated with the prevalence of PAF and PeAF, and its cutoff values are predictive for PAF and PeAF development independently of other AF risk factors.
(徳島大学機関リポジトリ): ● Metadata: 113224
(出版サイトへのリンク): ● Publication site (DOI): 10.1253/circj.CJ-18-0021
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29806623; ● Summary page in Scopus @ Elsevier: 2-s2.0-85049036945

(徳島大学機関リポジトリ: 113224, DOI: 10.1253/circj.CJ-18-0021, PubMed: 29806623, Elsevier: Scopus) Kensuke Matsumoto, Akira Onishi, Hirotsugu Yamada, Kenya Kusunose, Makiko Suto, Yutaka Hatani, Hiroki Matsuzoe, Kazuhiro Tatsumi, Hidekazu Tanaka and Ken-Ichi Hirata :
Noninvasive Assessment of Preload Reserve Enhances Risk Stratification of Patients With Heart Failure With Reduced Ejection Fraction,
Circulation. Cardiovascular Imaging, Vol.11, No.5, e007160, 2018.

(要約): BACKGROUND: The leg-positive pressure maneuver can safely and noninvasively apply preload stress without increase in total body fluid volume. The purpose of this study was to determine whether preload stress could be useful for risk stratification of patients with heart failure with reduced ejection fraction. METHODS AND RESULTS: For this study, 120 consecutive patients with heart failure with reduced ejection fraction were prospectively recruited. The stroke work index was estimated as product of stroke volume index and mean blood pressure, and the E/e' ratio was calculated to estimate ventricular filling pressure. The echocardiographic parameters were obtained both at rest and during leg-positive pressure stress. During the median follow-up period of 20 months, 30 patients developed adverse cardiovascular events. During preload stress, stroke work index increased significantly (from 3280+/-1371 to 3857+/-1581 mm Hg.mL/m(2); P<0.001) along with minimal changes in ventricular filling pressure (E/e', from 16+/-10 to 17+/-9; P<0.05) in patients without cardiovascular events. However, patients with cardiovascular events showed impairment of Frank-Starling mechanism (stroke work index, from 2863+/-969 to 2903+/-1084 mm Hg.mL/m(2); P=0.70) and a serious increase in E/e' ratio (from 19+/-11 to 25+/-14; P<0.001). Both the patients without contractile reserve and those without diastolic reserve exhibited worse event-free survival than the others (P<0.001). In a Cox proportional-hazards analysis, the changes in stroke work index (hazard ratio: 0.44 per 500 mm Hg.mL/m(2) increase; P=0.001) and in E/e' (hazard ratio: 2.58 per 5-U increase; P<0.001) were predictors of cardiovascular events. CONCLUSION: Contractile reserve and diastolic reserve during leg-positive pressure stress are important determinants of cardiovascular outcomes for patients with heart failure with reduced ejection fraction.
(出版サイトへのリンク): ● Publication site (DOI): 10.1161/CIRCIMAGING.117.007160
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29748312; ● Search Scopus @ Elsevier (PMID): 29748312; ● Search Scopus @ Elsevier (DOI): 10.1161/CIRCIMAGING.117.007160

(DOI: 10.1161/CIRCIMAGING.117.007160, PubMed: 29748312) Kenya Kusunose, Y Okushi, Hirotsugu Yamada, Susumu Nishio, Yuta Torii, Yukina Hirata, Y Saijo, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Prognostic Value of Frailty and Diastolic Dysfunction in Elderly Patients.,
Circulation Journal, Vol.82, No.8, 2103-2110, 2018.

(要約): High prevalence of frailty and of diastolic dysfunction (DD) in heart failure and high mortality in frail adults have been noted. We characterized frailty by quantifying differences on echocardiography, and assessed the added prognostic utility of frailty and DD grade in an elderly population. One hundred and ninety-one patients 65 years who had at least 1 cardiovascular risk factor were prospectively recruited for clinically indicated echocardiography at the present institute. Weight loss, exhaustion, and deficits in physical activity, gait speed, and handgrip strength were used to categorize patients as frail (3 features), intermediately frail (1 or 2 features), or non-frail (0 features). DD grade 2 was defined as severe. Frailty was associated with larger left atrial volume, smaller stroke volume, and worse DD grade after adjustment for age. In a period of 14 months, 29 patients (15%) had cardiovascular events. The addition of frailty score and severe DD significantly improved the prognostic power of a model containing male gender (model 1, male gender, χ=6.4; model 2, model 1 plus frailty score, χ=16.7, P=0.004; model 3, model 2 plus severe DD, χ=25.5, P=0.015). Both frailty and DD grade were significantly associated with future cardiovascular events in an elderly population with preserved ejection fraction and 1 risk factor of cardiovascular disease.
(徳島大学機関リポジトリ): ● Metadata: 113222
(出版サイトへのリンク): ● Publication site (DOI): 10.1253/circj.CJ-18-0017
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29709994; ● Summary page in Scopus @ Elsevier: 2-s2.0-85050588123

(徳島大学機関リポジトリ: 113222, DOI: 10.1253/circj.CJ-18-0017, PubMed: 29709994, Elsevier: Scopus) Tomoya Hara, Pham Tran Phuong, Daiju Fukuda, Koji Yamaguchi, Chie Murata, Sachiko Nishimoto, Shusuke Yagi, Kenya Kusunose, Hirotsugu Yamada, Soeki Takeshi, Tetsuzo Wakatsuki, Issei Imoto, Michio Shimabukuro and Masataka Sata :
Protease-Activated Receptor-2 Plays a Critical Role in Vascular Inflammation and Atherosclerosis in Apolipoprotein E-Deficient Mice.,
Circulation, Vol.138, No.16, 1706-1719, 2018.

(要約): -The coagulation system is closely linked with vascular inflammation, although the underlying mechanisms are still obscure. Recent studies show that protease-activated receptor (PAR)-2, a major receptor of activated factor X (FXa), are expressed in both vascular cells and leukocytes, suggesting that PAR-2 may contribute to the pathogenesis of inflammatory diseases. Here we investigated the role of PAR-2 in vascular inflammation and atherogenesis. -We generated apolipoprotein E-deficient ( ) mice lacking systemic PAR-2 expression ( ). mice which lack or express PAR-2 only in bone-marrow (BM) cells were also generated by BM transplantation. Atherosclerotic lesions were investigated after 20 weeks on a western-type diet (WTD) by histological analyses, quantitative RT-PCR, and western blotting. In vitro experiments using BM-derived macrophages were performed to confirm pro-inflammatory roles of PAR-2. The association between plasma FXa level and the severity of coronary atherosclerosis was also examined in humans who underwent coronary intervention. - mice showed reduced atherosclerotic lesions in the aortic arch (<0.05) along with features of stabilized atherosclerotic plaques such as less lipid deposition (<0.05), collagen loss (<0.01), macrophage accumulation (<0.05), and inflammatory molecule expression (<0.05) compared with mice. Systemic PAR2 deletion in mice significantly decreased the expression of inflammatory molecules in the aorta. The results of BM transplantation experiments demonstrated that PAR-2 in hematopoietic cells contributed to atherogenesis in mice. PAR-2 deletion did not alter metabolic parameters. In vitro experiments demonstrated that FXa or a specific peptide agonist of PAR-2 significantly increased expression of inflammatory molecules and lipid uptake in BM-derived macrophages from wild-type mice compared with those from PAR-2-deficient mice. Activation of NF- κB signaling was involved in PAR-2-associated vascular inflammation and macrophage activation. In humans who underwent coronary intervention, plasma FXa level independently correlated with the severity of coronary atherosclerosis as determined by Gensini score (<0.05) and plaque volume (<0.01). -PAR-2 signaling activates macrophages and promotes vascular inflammation, increasing atherosclerosis in mice. This signaling pathway may also participate in atherogenesis in humans.
(徳島大学機関リポジトリ): ● Metadata: 112891
(出版サイトへのリンク): ● Publication site (DOI): 10.1161/CIRCULATIONAHA.118.033544
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29700120; ● Summary page in Scopus @ Elsevier: 2-s2.0-85055611443

(徳島大学機関リポジトリ: 112891, DOI: 10.1161/CIRCULATIONAHA.118.033544, PubMed: 29700120, Elsevier: Scopus) Gulinu Maimaituxun, Michio Shimabukuro, Daiju Fukuda, Shusuke Yagi, Yukina Hirata, Takashi Iwase, Shoichiro Takao, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Takeshi Tobiume, Koji Yamaguchi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Masafumi Harada and Masataka Sata :
Local Thickness of Epicardial Adipose Tissue Surrounding the Left Anterior Descending Artery Is a Simple Predictor of Coronary Artery Disease - New Prediction Model in Combination With Framingham Risk Score.,
Circulation Journal, Vol.82, No.5, 1369-1378, 2018.

(要約): Compared with global cardiac adiposity, the local accumulation of fat surrounding coronary arteries might have a more direct impact on coronary artery disease (CAD). Here, we compared the local epicardial adipose tissue (EAT) thickness and global cardiac adiposity volumes for predicting CAD.Methods and Results:A total of 197 consecutive subjects underwent 320-slice multi-detector computed tomography coronary angiography and were segregated into CAD (1 coronary artery branch stenosis 50%) and non-CAD groups. EAT thickness was measured at the right coronary artery (EAT), the left anterior descending artery (EAT), and the left circumflex artery (EAT). Although EATand EATwere similar between the 2 groups, EATwas larger in the CAD group than in the non-CAD group (5.45±2.16 mm vs. 6.86±2.19 mm, P<0.001). EAT, after correcting for confounding factors, was strongly associated with CAD (r=0.276, P<0.001) and Gensini score (r=0.239, P<0.001). On multiple regression analysis, Framingham risk score combined with EATwas a strong predictor of CAD (adjusted R=0.121; P<0.001). The local fat thickness surrounding the LAD is a simple and useful surrogate marker for estimating the presence, severity, and extent of CAD, independent of classical cardiovascular risk factors.
(徳島大学機関リポジトリ): ● Metadata: 112879
(出版サイトへのリンク): ● Publication site (DOI): 10.1253/circj.CJ-17-1289
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29563352; ● Summary page in Scopus @ Elsevier: 2-s2.0-85045965929

(徳島大学機関リポジトリ: 112879, DOI: 10.1253/circj.CJ-17-1289, PubMed: 29563352, Elsevier: Scopus) 清水郁子, 瀬野弘光, 山口浩司, 楠瀬賢也, 山田博胤, 若槻哲三, 添木武, 佐田政隆, 岩瀬俊, 黒部裕嗣, 北川哲也 :
Calcified Amorphous Tumorに対し腫瘍摘出術を行った一例,
四国医学雑誌, Vol.74, No.1-2, 84, 2018年. K Adachi, S Hashiguchi, M Saito, S Kashiwagi, T Miyazaki, H Kawai, Hirotsugu Yamada, T Iwase, Masashi Akaike, Shoichiro Takao, M Kobayashi, M Ishizaki, T Matsumura, M Mori-Yoshimura and E Kimura :
Detection and management of cardiomyopathy in female dystrophinopathy carriers,
Journal of the Neurological Sciences, Vol.386, 74-80, 2018.

(要約): Regular health checkups for mothers of patients with Duchenne muscular dystrophy have been performed at National Hospital Organization Tokushima Hospital since 1994. Among 43 mothers participated in this study, 28 dystrophinopathy carriers were identified. Skeletal and cardiac muscle functions of these subjects were examined. High serum creatine kinase was found in 23 subjects (82.1%). Obvious muscle weakness was present in 5 (17.8%) and had progressed from 1994 to 2015. Cardiomyopathy was observed in 15 subjects (60.0%), including dilated cardiomyopathy-like damage that was more common in the left ventricular (LV) posterior wall. Late gadolinium enhancement on cardiac MRI was found in 5 of 6 subjects, suggesting fibrotic cardiac muscle. In speckle tracking echocardiography performed seven years later, global longitudinal strain was decreased in these subjects, indicating LV myocardial contractile abnormality. These results suggest that female dystrophinopathy carriers should receive regular checkups for detection and treatment of cardiomyopathy, even if they have no cardiac symptoms.
(キーワード): Adult / Cardiomyopathies / Contrast Media / Creatine Kinase / Disease Management / Dystrophin / Electrocardiography / Female / Gadolinium / Humans / Image Processing, Computer-Assisted / Middle Aged / Muscle, Skeletal / Mutation / Natriuretic Peptide, Brain / Neuroimaging / Neurologic Examination / Retrospective Studies
(徳島大学機関リポジトリ): ● Metadata: 115572
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jns.2017.12.024
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29358000; ● Search Scopus @ Elsevier (PMID): 29358000; ● Search Scopus @ Elsevier (DOI): 10.1016/j.jns.2017.12.024

(徳島大学機関リポジトリ: 115572, DOI: 10.1016/j.jns.2017.12.024, PubMed: 29358000) Masahiro Nakabachi, Satoshi Yamada, Hiroyuki Iwano, Taichi Hayashi, Kazunori Okada, Kenya Kusunose, Kiyotaka Watanabe, Tomoko Ishizu, Kazuaki Wakami, Hirotsugu Yamada, Kaoru Dohi, Yoshihiro Seo, Nobuyuki Ohte, Chikara Shimizu and Taisei Mikami :
Left Ventricular Mass Influences Relationship Between Filling Pressure and Early-Diastolic Ratio of Inflow Velocity to Mitral Annular Velocity (E/e').,
Circulation Journal, Vol.82, No.3, 732-738, 2018.

(要約): Early-diastolic mitral annular velocity (e') and the ratio of early-diastolic left ventricular (LV) inflow velocity (E) to e' (E/e') have been widely used as indexes of LV relaxation and filling pressure, respectively. However, many recent studies have demonstrated that they are not reliable in various clinical settings. We thus investigated the factors influencing these echocardiographic parameters in a multicenter study.Methods and esults:The study group comprised 69 patients, referred for cardiac catheterization, and enrolled in 5 university hospitals. Time constant ( ) and LV mean diastolic pressure (LVMDP) were measured using a micromanometer-tipped catheter. Although e' only weakly correlated with (r=-0.35, P<0.01), E/e' modestly correlated with LVMDP (r=0.48, P<0.001). Multivariable analysis revealed that hypertension ( =-0.33, P<0.01) and LV ejection fraction (LVEF) ( =0.44, P<0.001) were the independent determinants of e', and LV mass index (LVMI) ( =0.37, P<0.001) and LVMDP ( =0.47, P<0.001) were those of E/e'. Additionally, E/e' significantly correlated with LVMDP in patients with normal LVMI (r=0.74, P<0.001) but not in those with increased LVMI. The coincidence of hypertension and LVEF affected the relationship between LV relaxation and e', whereas LVMI altered the relationship between LV filling pressure and E/e'. Thus, clinical conditions associated with an increase in LVMI, such as LV hypertrophy and LV dilatation, should be considered when estimating the filling pressure from E/e'.
(出版サイトへのリンク): ● Publication site (DOI): 10.1253/circj.CJ-17-1019
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29311519; ● Search Scopus @ Elsevier (PMID): 29311519; ● Search Scopus @ Elsevier (DOI): 10.1253/circj.CJ-17-1019

(DOI: 10.1253/circj.CJ-17-1019, PubMed: 29311519) Yukina Hirata, Hirotsugu Yamada, Kenya Kusunose, Susumu Nishio, Yuta Torii, Yuki Horike and Masataka Sata :
Provocation of clinically significant left ventricular outflow tract obstruction by postural change in patients with sigmoid septum.,
Journal of Echocardiography, Vol.16, No.4, 173-174, 2018.

(徳島大学機関リポジトリ): ● Metadata: 114210
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s12574-018-0372-x
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29388159; ● Summary page in Scopus @ Elsevier: 2-s2.0-85045145878

(徳島大学機関リポジトリ: 114210, DOI: 10.1007/s12574-018-0372-x, PubMed: 29388159, Elsevier: Scopus) 楠瀬賢也, 山田博胤 :
心エコーによる右室機能評価法はどこまで進んでいるか,
Heart View, Vol.22, No.1, 10-17, 2018年.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390009224491884032

(CiNii: 1390009224491884032) 鳥居裕太, 山田博胤 :
大動脈疾患編,
心エコー, Vol.19, No.10, 1006-1013, 2018年. 工藤萌宏, 待井典剛, 小野利夫, 大城義人, 高橋隆, 種田嘉信, 比嘉盛丈, 八木秀介, 仲地健, 小林淳, 及川雅啓, 山田博胤, 竹石恭知, 佐田政隆, 島袋充生 :
時効型インスリン療法中の2型糖尿病患者におけるダパグリフロジンの血糖日内変動に及ぼす効果,
肥満研究, Vol.24, No.Suppl, 222, 2018年. Hiromu Yamazaki, Shusuke Yagi, Yuta Torii, Rie Amano, Yasuyuki Oomichi, Teruaki Sangawa, Daiju Fukuda, Muneyuki Kadota, Takayuki Ise, Rie Ueno, Tomoya Hara, Kenya Kusunose, Tomomi Matsuura, Takeshi Tobiume, Koji Yamaguchi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Edoxaban improves acute venous thromboembolism while preserving protein C and protein S levels,
Journal of Cardiology, Vol.71, No.3, 305-309, 2017.

(要約): It is well known that warfarin inhibits the synthesis of vitamin K-dependent anticoagulants, including thrombin, protein C and S, and factor Xa, leading, paradoxically, to an initial hypercoagulable state. Edoxaban, a direct inhibitor of activated factor X is widely used for the treatment of acute venous thromboembolism (VTE). However, the effect of edoxaban on circulating coagulation factors, in patients with acute VTE, remains unknown. We enrolled 57 patients with acute VTE with/without pulmonary embolism treated with edoxaban (n=37) or warfarin (n=20) in a clinical setting. Before treatment and 2 weeks after treatment, we evaluated thrombotic burden using ultrasound or computed tomography angiography. We also evaluated thrombin generation, represented by prothrombin fragment F1+2; thrombus degradation, represented by D-dimer; and levels of anticoagulants, including protein C, protein S, and antithrombin III. Both edoxaban and warfarin treatment improved thrombotic burden and decreased prothrombin fragment F1+2, and D-dimer. Edoxaban treatment preserved protein C and protein S levels. In contrast, warfarin decreased protein C and protein S levels. Neither treatment affected antithrombin III. Edoxaban improves VTE while preserving protein C and protein S levels, thereby indicating that edoxaban improves thrombotic burden while maintaining levels of anticoagulants.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jjcc.2017.09.009
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29100817; ● Summary page in Scopus @ Elsevier: 2-s2.0-85032912457

(DOI: 10.1016/j.jjcc.2017.09.009, PubMed: 29100817, Elsevier: Scopus) Shusuke Yagi, Ken-ichi Aihara, Takeshi Kondo, Kiyoe Kurahashi, Sumiko Yoshida, Itsuro Endo, Daiju Fukuda, Yutaka Nakaya, Kin-Ichiro Suwaki, Takashi Takeji, Toshihiro Wada, Masdan Hotimah Salim, Saori Hama, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Koji Yamaguchi, Takeshi Tobiume, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Munehide Matsuhisa, Michio Shimabukuro, Masashi Akaike and Masataka Sata :
Predictors for the Treatment Effect of Sodium Glucose Co-transporter 2 Inhibitors in Patients with Type 2 Diabetes Mellitus.,
Advances in Therapy, Vol.35, No.1, 124-134, 2017.

(要約): Predictors for the effect of sodium glucose co-transporter 2 (SGLT2) inhibitors at lowering hemoglobin A1c (HbA1c) levels in type 2 diabetes mellitus patients remain unclear. We therefore aimed to elucidate these predictors in type 2 diabetes patients after 3 months of SGLT2 treatment. A total of 302 consecutive type 2 diabetes patients who had been treated with SGLT2 inhibitors as monotherapy or add-on therapy to existing antidiabetic treatments were enrolled retrospectively. After excluding 27 patients whose HbA1c levels could not be evaluated 3 months after treatment, the glucose-lowering effects of SGLT2 inhibitors were assessed in 275 patients by measuring HbA1c levels before and 3 months after treatment. The predictors for changes in HbA1c levels after 3 months of treatment were evaluated. SGLT2 inhibitor treatment for 3 months decreased HbA1c levels from 7.8 ± 1.2% to 7.4 ± 1.0% (p < 0.0001). A multiple regression analysis showed that the independent determinants for SGLT2 inhibitor treatment effect included decreased HbA1c levels after 1 month of treatment, high baseline HbA1c levels, and a high estimated glomerular filtration rate (eGFR). We show that type 2 diabetes patients who received the greatest glucose-lowering effect with SGLT2 inhibitor treatment were those with preserved renal function (high baseline eGFR) and high baseline HbA1c levels. Moreover, SGLT2 inhibitor treatment efficacy could be predicted by the patients' initial response to treatment.
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s12325-017-0639-z
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29185199; ● Summary page in Scopus @ Elsevier: 2-s2.0-85035102977

(DOI: 10.1007/s12325-017-0639-z, PubMed: 29185199, Elsevier: Scopus) Shusuke Yagi, Takeshi Soeki, Ken-Ichi Aihara, Daiju Fukuda, Takayuki Ise, Muneyuki Kadota, Sachiko Bando, Tomomi Matsuura, Takeshi Tobiume, Koji Yamaguchi, Kenya Kusunose, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro, Masashi Akaike and Masataka Sata :
Low Serum Levels of Eicosapentaenoic Acid and Docosahexaenoic Acid are Risk Factors for Cardiogenic Syncope in Patients with Brugada Syndrome,
International Heart Journal, Vol.58, No.5, 720-723, 2017.

(要約): The n-3 polyunsaturated fatty acids (PUFAs), including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have antiarrhythmic effects, possibly via modulation of the cardiac ion channels. Nevertheless, it is unknown whether low serum levels of n-3 PUFAs are risk factors for ventricular fibrillation in patients with Brugada syndrome (BrS). We retrospectively reviewed data from 62 men with BrS and evaluated their serum levels of EPA and DHA, and the risk factors for sudden cardiac death, including a history of cardiogenic syncope. Nineteen patients had a history of cardiogenic syncope, and their EPA and DHA levels were significantly lower than those of the patients without syncope. Multivariate logistic regression analysis revealed that low EPA and DHA levels were associated with the incidence of syncope. The receiver-operator characteristic curve showed the area under the curves of EPA and DHA for history of syncope were 0.84 and 0.72, respectively. In conclusion, low levels of EPA and DHA are risk factors for cardiogenic syncope in patients with BrS, which suggests that n-3 PUFAs play important roles in preventing ventricular fibrillation in BrS.
(キーワード): Adult / Aged / Aged, 80 and over / Biomarkers / Brugada Syndrome / Chromatography, Gas / Docosahexaenoic Acids / Eicosapentaenoic Acid / Electrocardiography / Follow-Up Studies / Humans / Incidence / 日本 (Japan) / Male / Middle Aged / Prevalence / ROC Curve / Retrospective Studies / Risk Assessment / Risk Factors / Syncope / Young Adult
(出版サイトへのリンク): ● Publication site (DOI): 10.1536/ihj.16-278
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28966307; ● CiNii @ 国立情報学研究所 (CRID): 1390282680202467328; ● Summary page in Scopus @ Elsevier: 2-s2.0-85032215381

(DOI: 10.1536/ihj.16-278, PubMed: 28966307, CiNii: 1390282680202467328, Elsevier: Scopus) Yuriko Takagawa, Shusuke Yagi, Takayuki Ise, Ayumi Ishii, Koji Nishikawa, Daiju Fukuda, Kenya Kusunose, Tomomi Matsuura, Takeshi Tobiume, Koji Yamaguchi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Michio Shimabukuro, Shinsuke Katoh, Ken-ichi Aihara, Masashi Akaike and Masataka Sata :
Improved Exercise Capacity After Cardiac Rehabilitation Is Associated with Reduced Visceral Fat in Patients with Chronic Heart Failure.,
International Heart Journal, Vol.58, No.5, 746-751, 2017.

(要約): Participation in a comprehensive cardiac rehabilitation (CR) program has been shown to reduce mortality and improve exercise capacity and symptoms in patients with chronic heart failure (CHF). Reduced exercise capacity leads to a concomitant reduction of skeletal muscle mass and accumulation of body fat. However, it is currently unknown whether CR reduces visceral adipose tissue (VAT) and/or subcutaneous abdominal adipose tissue (SAT) in patients with CHF. In addition, the body composition associated with improved exercise capacity after CR in patients with CHF has not been previously studied. Nineteen CHF patients who were categorized as NYHA functional class II or III and had received optimal medical treatment including a CR program for 5 months were enrolled in this study. The CR program significantly increased peak VO and reduced B-type natriuretic peptide. In addition, fat and body composition analysis showed reductions in the visceral fat tissue (VAT) area, subcutaneous abdominal adipose tissue (SAT) area, body weight, and total fat weight after CR. There were no changes in total water weight and total muscle weight. Single regression analysis revealed that the amelioration of reduced exercise capacity seen after CR is associated with reduced VAT area but not with SAT area or body weight. In conclusion, CR reduces VAT and improves exercise capacity in patients with CHF. This suggests that reducing VAT is important for CR to be most effective in the treatment of CHF.
(キーワード): Body Composition / Cardiac Rehabilitation / Exercise Tolerance / Female / Follow-Up Studies / 心不全 (heart failure) / Humans / Intra-Abdominal Fat / Male / Middle Aged / 肥満症 (obesity) / 酸素消費 (oxygen consumption) / Prognosis / Retrospective Studies / Weight Loss
(徳島大学機関リポジトリ): ● Metadata: 110111
(出版サイトへのリンク): ● Publication site (DOI): 10.1536/ihj.16-454
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28966316; ● Summary page in Scopus @ Elsevier: 2-s2.0-85032221042

(徳島大学機関リポジトリ: 110111, DOI: 10.1536/ihj.16-454, PubMed: 28966316, Elsevier: Scopus) Shusuke Yagi, Yukina Hirata, Takayuki Ise, Kenya Kusunose, Hirotsugu Yamada, Daiju Fukuda, Salim Masdan Hotimah, G Maimaituxun, Susumu Nishio, Yuriko Takagawa, Saori Hama, Tomomi Matsuura, Koji Yamaguchi, Takeshi Tobiume, Takeshi Soeki, Tetsuzo Wakatsuki, Ken-ichi Aihara, Masashi Akaike, Michio Shimabukuro and Masataka Sata :
Canagliflozin reduces epicardial fat in patients with type 2 diabetes mellitus.,
Diabetology & Metabolic Syndrome, Vol.9, 78, 2017.

(要約): It is unknown whether canagliflozin, a selective sodium glucose co-transporter 2 inhibitor, reduces epicardial adipose tissue (EAT) thickness, which is associated with insulin resistance and is a risk factor for coronary artery disease. We administered 100 mg of canagliflozin for 6 months to 13 patients with type 2 diabetes mellitus. We evaluated glycemic control, visceral adipose tissue (VAT) area and subcutaneous adipose tissue (SAT) area, and skeletal muscle mass by using impedance methods, and EAT thickness by using echocardiography. Canagliflozin treatment for 6 months decreased hemoglobin A1c level from 7.1 ± 0.5% to 6.7 ± 0.6% (P < 0.05) and decreased EAT thickness from 9.3 ± 2.5 to 7.3 ± 2.0 mm (P < 0.001), along with a trend of decreasing VAT and SAT area. No association was found between any of these changes. Canagliflozin reduced EAT thickness in patients with type 2 diabetes mellitus independent of its effect on lowering blood glucose, suggesting that canagliflozin may have an effect in preventing cardiovascular events in these patients (UMIN000021327).
(徳島大学機関リポジトリ): ● Metadata: 114544
(出版サイトへのリンク): ● Publication site (DOI): 10.1186/s13098-017-0275-4
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29034006; ● Summary page in Scopus @ Elsevier: 2-s2.0-85030465923

(徳島大学機関リポジトリ: 114544, DOI: 10.1186/s13098-017-0275-4, PubMed: 29034006, Elsevier: Scopus) Kenya Kusunose, Hirotsugu Yamada, Susumu Nishio, Yuta Torii, Yukina Hirata, Hiromitsu Seno, Yoshihito Saijo, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Preload Stress Echocardiography Predicts Outcomes in Patients With Preserved Ejection FractionandLow-GradientAorticStenosis,
Circulation. Cardiovascular Imaging, Vol.10, No.10, 2017.

(要約): The projected aortic valve area (AVA) at a normal transvalvular flow rate using dobutamine is helpful to determine the actual severity of aortic stenosis (AS) and to predict risk of adverse events in low-gradient AS cases with unclear surgical indication. Our study aimed to identify the independent and incremental value of preload stress echocardiography-derived AVA to predict outcomes in patients with preserved ejection fraction and low-gradient AS. We prospectively performed echocardiographic studies in 79 patients with low-gradient AS (age, 77±7 years; 30% men) with preload stress echocardiography using leg positive pressure. AVA was calculated using AVA and transvalvular flow rate at baseline and during leg positive pressure. The primary end point was the decision for aortic valve surgery or cardiac death. During a median period of 19 months, 23 patients had the decision for aortic valve surgery, and none died during follow-up. In a stepwise multivariable analysis, indexed AVA (AVAi; hazard ratio, 2.00 per 0.1 cm/m decrease; 95% confidence interval, 1.36-2.96; <0.001) was associated with the primary end point. Using a receiver operating characteristic curve analysis, the best cutoff value of AVAi for predicting cardiac events was <0.72 cm/m. By incorporating AVAi into AVAi at baseline, continuous net reclassification index for cardiac events was 0.48 (=0.04). In patients with low-gradient AS, indexed AVA derived from preload stress echocardiography can be useful to predict risk of adverse events. The present article should be considered as a proof of concept study, and we think that larger multicenter studies are warranted.
(キーワード): Aged / Aged, 80 and over / Aortic Valve / Aortic Valve Stenosis / Area Under Curve / Disease Progression / Disease-Free Survival / Echocardiography, Stress / Female / Humans / Kaplan-Meier Estimate / Male / Models, Cardiovascular / Predictive Value of Tests / Prospective Studies / ROC Curve / Severity of Illness Index / Stroke Volume / Time Factors / Ventricular Function, Left
(出版サイトへのリンク): ● Publication site (DOI): 10.1161/CIRCIMAGING.117.006690
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29021259; ● Summary page in Scopus @ Elsevier: 2-s2.0-85031850278

(DOI: 10.1161/CIRCIMAGING.117.006690, PubMed: 29021259, Elsevier: Scopus) Susumu Nishio, Kenya Kusunose, Hirotsugu Yamada, Yukina Hirata, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Echocardiographic Epicardial Adipose Tissue Thickness Is Associated with Symptomatic Coronary Vasospasm during Provocative Testing.,
Journal of the American Society of Echocardiography, Vol.30, No.10, 1021-1027, 2017.

(要約): Epicardial adipose tissue (EAT) is the ectopic visceral fat surrounding the heart, which plays an important role in atherosclerosis of the coronary arteries via endothelial damage. Several studies have also suggested that vasospasm with angina (VSA) causes endothelial dysfunction in the coronary arteries. The aim of this study was to evaluate the thickness of EAT in the anterior interventricular groove (EAT-AIG) using echocardiography in patients who had no obstructive coronary artery disease and were suspected of having VSA. Sixty-five patients who underwent intracoronary acetylcholine provocation testing for clinical indications were prospectively enrolled. VSA was diagnosed by coronary artery stenosis increase of >90% and the presentation of chest pain with ischemic changes on electrocardiography. Subjects were divided into two groups, with and without significant coronary spasm (VSA group, 30 patients; non-VSA group, 35 patients), consistent with acetylcholine provocation testing. EAT-AIG thickness was significantly greater in the VSA group than in the non-VSA group (8.2 2.7 vs 6.1 2.5 mm, P = .002). By receiver operating characteristic analysis, EAT-AIG thickness had a high C statistic (area under the curve = 0.81, P < .001) after adjustment for conventional risk factors (smoking, diabetes mellitus, and dyslipidemia). EAT-AIG thickness had incremental diagnostic value over other conventional risk factors (area under the curve = 0.81 vs 0.64, P for comparison = .020). EAT-AIG thickness, which is noninvasively and easily measured using transthoracic echocardiography, can be one of multiple clinical variables associated with VSA.
(徳島大学機関リポジトリ): ● Metadata: 110928
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.echo.2017.06.024
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28843368; ● Search Scopus @ Elsevier (PMID): 28843368; ● Search Scopus @ Elsevier (DOI): 10.1016/j.echo.2017.06.024

(徳島大学機関リポジトリ: 110928, DOI: 10.1016/j.echo.2017.06.024, PubMed: 28843368) Yukina Hirata, Kenya Kusunose, Hirotsugu Yamada, Rikuto Shimizu, Yuta Torii, Susumu Nishio, Yoshihito Saijo, Shoichiro Takao, Takeshi Soeki and Masataka Sata :
Age-related changes in morphology of left atrial appendage in patients with atrial fibrillation.,
The International Journal of Cardiovascular Imaging, Vol.34, No.2, 321-328, 2017.

(要約): The purpose of this study was to evaluate the relationship between age and frequency of left atrial appendage (LAA) morphology in patients with atrial fibrillation (AF) compared with sinus rhythm (SR). We enrolled 145 AF patients, and 199 SR patients for the control group without any cardiovascular disease. LAA volume index (LAAVi) and morphology were assessed by electrocardiogram-gated computed tomography angiography. LAA morphology was classified into "chicken wing" or "non-chicken wing" according to the previously described classification. There was no significant trend in frequency of non-chicken wing morphology among ages in the SR group (p = 0.36 for trend), whereas the frequency was negatively related to age in the AF group (p = 0.002 for trend). In multivariable logistic regression, age > 65 (odds ratio [OR] 0.42, p = 0.002) and duration of AF (OR 0.53, p = 0.010) and LAAVi (OR 0.62, p = 0.017) were independent factors of non-chicken wing LAA morphology in the AF group. LAA morphology is affected by age, especially in patients with AF. When we utilize non-chicken wing LAA morphology as a stroke risk factor in patients with AF, we should pay attention to their age.
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s10554-017-1232-x
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28808846; ● Search Scopus @ Elsevier (PMID): 28808846; ● Search Scopus @ Elsevier (DOI): 10.1007/s10554-017-1232-x

(DOI: 10.1007/s10554-017-1232-x, PubMed: 28808846) Dean S. Picone, Martin G. Schultz, Petr Otahal, Svend Aakhus, Ahmed M. Al-Jumaily, J Andrew Black, Willem J. Bos, John B. Chambers, Chen-Huan Chen, Hao-Min Cheng, Antoine Cremer, Justin E. Davies, Nathan Dwyer, Brian A. Gould, Alun D. Hughes, Peter S. Lacy, Esben Laugesen, Fuyou Liang, Roman Melamed, Sandy Muecke, Nobuyuki Ohte, Sho Okada, Stefano Omboni, Christian Ott, Xiaoqing Peng, Telmo Pereira, Giacomo Pucci, Ronak Rajani, Philip Roberts-Thomson, Niklas B. Rossen, Daisuke Sueta, Manish D. Sinha, Roland E. Schmieder, Harold Smulyan, Velandai K. Srikanth, Ralph Stewart, George A. Stouffer, Kenji Takazawa, Jiguang Wang, Berend E. Westerhof, Franz Weber, Thomas Weber, Bryan Williams, Hirotsugu Yamada, Eiichiro Yamamoto and James E. Sharman :
Accuracy of Cuff-Measured Blood Pressure: Systematic Reviews and Meta-Analyses.,
Journal of the American College of Cardiology, Vol.70, No.5, 572-586, 2017.

(要約): Hypertension (HTN) is the single greatest cardiovascular risk factor worldwide. HTN management is usually guided by brachial cuff blood pressure (BP), but questions have been raised regarding accuracy. This comprehensive analysis determined the accuracy of cuff BP and the consequent effect on BP classification compared with intra-arterial BP reference standards. Three individual participant data meta-analyses were conducted among studies (from the 1950s to 2016) that measured intra-arterial aortic BP, intra-arterial brachial BP, and cuff BP. A total of 74 studies with 3,073 participants were included. Intra-arterial brachial systolic blood pressure (SBP) was higher than aortic values (8.0 mm Hg; 95% confidence interval [CI]: 5.9 to 10.1 mm Hg; p < 0.0001) and intra-arterial brachial diastolic BP was lower than aortic values (-1.0 mm Hg; 95% CI: -2.0 to -0.1 mm Hg; p = 0.038). Cuff BP underestimated intra-arterial brachial SBP (-5.7 mm Hg; 95% CI: -8.0 to -3.5 mm Hg; p < 0.0001) but overestimated intra-arterial diastolic BP (5.5 mm Hg; 95% CI: 3.5 to 7.5 mm Hg; p < 0.0001). Cuff and intra-arterial aortic SBP showed a small mean difference (0.3 mm Hg; 95% CI: -1.5 to 2.1 mm Hg; p = 0.77) but poor agreement (mean absolute difference 8.0 mm Hg; 95% CI: 7.1 to 8.9 mm Hg). Concordance between BP classification using the Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure cuff BP (normal, pre-HTN, and HTN stages 1 and 2) compared with intra-arterial brachial BP was 60%, 50%, 53%, and 80%, and using intra-arterial aortic BP was 79%, 57%, 52%, and 76%, respectively. Using revised intra-arterial thresholds based on cuff BP percentile rank, concordance between BP classification using cuff BP compared with intra-arterial brachial BP was 71%, 66%, 52%, and 76%, and using intra-arterial aortic BP was 74%, 61%, 56%, and 65%, respectively. Cuff BP has variable accuracy for measuring either brachial or aortic intra-arterial BP, and this adversely influences correct BP classification. These findings indicate that stronger accuracy standards for BP devices may improve cardiovascular risk management.
(キーワード): 血圧 (blood pressure) / Blood Pressure Determination / Cardiovascular Diseases / Equipment Design / Reproducibility of Results
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jacc.2017.05.064
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28750701; ● Summary page in Scopus @ Elsevier: 2-s2.0-85024099705

(DOI: 10.1016/j.jacc.2017.05.064, PubMed: 28750701, Elsevier: Scopus) Kenya Kusunose, Hirotsugu Yamada, Susumu Nishio, Yukina Hirata, Hiromitsu Seno, Y Saijo, Takayuki Ise, Takeshi Tobiume, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Echocardiographic Predictors for Worsening of Six-Minute Walk Distances in Patients With Systemic Sclerosis (Scleroderma),
The American Journal of Cardiology, Vol.120, No.2, 315-321, 2017.

(要約): Change in 6-minute walk distance (6MWD) has been used as a clinical marker in pulmonary hypertension. Determinants and worsening of 6MWD remain a matter of debate because nonpulmonary factors have an impact on the 6MWD. We hypothesized that future reduction of 6MWD in patients with systemic sclerosis (SSc) was more closely associated with cardiac dysfunction. We prospectively performed standard clinical and echocardiographic evaluations in SSc patients with the 6-minute walk test at enrollment. Features associated with the 6MWD were sought in a multiple linear regression analysis and compared using standardized . Worsening of the 6MWD was defined as a 15% reduction and served as the primary outcome. Eighty-one patients were included. In the multivariate analysis, baseline 6MWD was related to SSc severity score ( = -0.250, p = 0.024), left atrial volume index ( = -0.222, p = 0.046), right ventricular fractional area change ( = 0.252, p = 0.025), and the ratio of mean pulmonary artery pressure and cardiac output ( = -0.31, p = 0.002). During follow-up, 20 patients reached the primary outcome. In sequential Cox models, a model based on right ventricular fractional area change at baseline (chi-square 4.8) was improved by left atrial volume index (chi-square 10.3, p = 0.007). In conclusion, determinants and worsening of 6MWD are explained by cardiac factors. When using the 6MWD as a clinical marker in pulmonary hypertension patients, their left ventricular diastolic function and right ventricular systolic function should be taken into consideration.
(キーワード): Diastole / Disease Progression / Echocardiography, Doppler / Female / Follow-Up Studies / Humans / Hypertension, Pulmonary / Male / Middle Aged / Predictive Value of Tests / Prospective Studies / Scleroderma, Systemic / Stroke Volume / Systole / Time Factors / Ventricular Function, Left / Ventricular Function, Right / Walking
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.amjcard.2017.04.024
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28532772; ● Search Scopus @ Elsevier (PMID): 28532772; ● Search Scopus @ Elsevier (DOI): 10.1016/j.amjcard.2017.04.024

(DOI: 10.1016/j.amjcard.2017.04.024, PubMed: 28532772) Kenya Kusunose, Hirotsugu Yamada, Susumu Nishio, Ayumi Ishii, Yukina Hirata, Hiromitsu Seno, Yoshihito Saijo, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
RV Myocardial Strain During Pre-Load Augmentation Is Associated With Exercise Capacity in Patients With Chronic HF,
JACC. Cardiovascular Imaging, Vol.10, No.10, 1240-1249, 2017.

(要約): The aim of this study was to assess the relationship between right ventricular (RV) function during pre-load augmentation and exercise tolerance. Peak oxygen uptake (VO2) is a strong predictor of mortality in chronic heart failure. Cardiac function during pre-load augmentation is an important part of the phenomenon in the evaluation of exercise capacity. We prospectively performed echocardiographic studies in 68 chronic heart failure patients with cardiopulmonary exercise testing (mean age 60 ± 12 years; 69% male). After resting evaluations, echocardiographic parameters were repeated during leg positive pressure (LPP). Exercise capacity was assessed by peak VO2 in all patients (left ventricular ejection fraction: 43 ± 15%). Patients with severely reduced exercise capacity (peak VO2 <14 ml/kg/min) had significantly lower stroke volume index, left ventricular global longitudinal strain and RV strain and higher filling pressure (E/e' and pulmonary arterial systolic pressure) than the remainder. Stroke volume index ( = 0.49), global longitudinal strain ( = -0.61), E/e' ( = -0.32), pulmonary arterial systolic pressure ( = -0.57), and RV strain ( = -0.66) during LPP were independently correlated to peak VO2 (all p < 0.01). RV strain during LPP was the most powerful predictor in identifying patients with severely reduced exercise capacity (cut off value: -17%; sensitivity: 81%; specificity: 88%; areas under the curve: 0.88; p < 0.001) compared with other variables including resting parameters. RV strain during pre-load augmentation correlated independently to peak VO2 and was a powerful predictor in identifying patients with severely reduced exercise capacity.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jcmg.2017.03.022
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28734918; ● Summary page in Scopus @ Elsevier: 2-s2.0-85025467938

(DOI: 10.1016/j.jcmg.2017.03.022, PubMed: 28734918, Elsevier: Scopus) Hiroki Matsuzoe, Kensuke Matsumoto, Hidekazu Tanaka, Yutaka Hatani, Keiko Hatazawa, Hiroyuki Shimoura, Junichi Ooka, Hiroyuki Sano, Keiko Ryo-Koriyama, Toshiro Shinke, Hirotsugu Yamada, Yutaka Okita and Ken-Ichi Hirata :
Significant Prognostic Value of Acute Preload Stress Echocardiography Using Leg-Positive Pressure Maneuver for Patients With Symptomatic Severe Aortic Stenosis Awaiting Aortic Valve Intervention.,
Circulation Journal, Vol.81, No.12, 1927-1935, 2017.

(要約): Although aortic valve intervention is recommended for virtually all symptomatic patients with aortic stenosis (AS), how urgently the intervention should be performed remains controversial. The aim of this study was thus to determine whether the preload reserve in response to leg-positive pressure (LPP) maneuver could serve for decision-making for AS patients awaiting aortic valve intervention.Methods and esults:Sixty-eight patients with symptomatic AS, who were referred for aortic valve intervention, were recruited. Stroke volume (SV) was assessed by means of pulsed-wave Doppler, and the ratio between transmitral E wave and mitral annular velocity (e') was calculated to estimate ventricular filling pressure. While waiting for intervention, 11 patients experienced preoperative cardiac events. During acute preload stress, forward SV for patients without cardiac events increased significantly (from 43 9 to 49 10 mL/m, P<0.01) along with a minimal change in filling pressure (E/e': from 20 8 to 21 9, NS). For patients with cardiac events, the Frank-Starling mechanism was significantly impaired (SVi: from 40 9 to 38 7 mL/m, NS), while filling pressure increased to the critical level (E/e': from 24 8 to 31 8, P<0.001). Both the patients without flow reserve ( SVi <4.5 mL/m) and those without diastolic reserve ( E/e' ·2.9) exhibited significantly worse event-free survival than the others (P<0.05, respectively). Assessment of preload reserve during LPP stress could facilitate risk stratification of patients with severe AS waiting for aortic valve intervention.
(キーワード): Aged / Aged, 80 and over / Aortic Valve / Aortic Valve Stenosis / Echocardiography, Stress / Female / Humans / Male / Prognosis / Risk Assessment / Ventricular Pressure
(出版サイトへのリンク): ● Publication site (DOI): 10.1253/circj.CJ-17-0143
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28659550; ● Search Scopus @ Elsevier (PMID): 28659550; ● Search Scopus @ Elsevier (DOI): 10.1253/circj.CJ-17-0143

(DOI: 10.1253/circj.CJ-17-0143, PubMed: 28659550) Akira Takashima, Tatsuro Ogata, Hirotsugu Yamada, Tetsuzo Wakatsuki and Masataka Sata :
Intracardiac echocardiography-guided biopsy of a lipomatous cardiac tumor arising from the interatrial septum.,
Circulation Journal, Vol.81, No.10, 1553-1555, 2017.

(出版サイトへのリンク): ● Publication site (DOI): 10.1253/circj.CJ-17-0138
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28367861; ● Summary page in Scopus @ Elsevier: 2-s2.0-85030104785

(DOI: 10.1253/circj.CJ-17-0138, PubMed: 28367861, Elsevier: Scopus) Maimaituxun Gulinu, Michio Shimabukuro, Hotimah Masdan Salim, Minoru Tabata, Daisuke Yuji, Yoshihisa Morimoto, Takeshi Akasaka, Tomomi Matsuura, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Takeshi Soeki, Takaki Sugimoto, Masashi Tanaka, Shuichiro Takanashi and Masataka Sata :
Gender-linked impact of epicardial adipose tissue volume in patients who underwent coronary artery bypass graft surgery or non-coronary valve surgery,
PLoS ONE, Vol.12, No.6, e0177170, 2017.

(要約): Traditional and non-traditional risk factors for atherosclerotic cardiovascular disease (ASCVD) are different between men and women. Gender-linked impact of epicardial adipose tissue volume (EATV) in patients undergoing coronary artery bypass grafting (CABG) remains unknown. Gender-linked impact of EATV, abdominal fat distribution and other traditional ASCVD risk factors were compared in 172 patients (men: 115; women: 57) who underwent CABG or non-coronary valvular surgery (non-CABG). In men, EATV, EATV index (EATV/body surface area) and the markers of adiposity such as body mass index, waist circumference and visceral fat area were higher in the CABG group than in the non-CABG group. Traditional ASCVD risk factors were also prevalent in the CABG group. In women, EATV and EATV index were higher in the CABG group, but other adiposity markers were comparable between CABG and non-CABG groups. Multivariate logistic regression analysis showed that in men, CABG was determined by EATV Index and other ASCVD risk factors including hypertension, dyslipidemia, adiponectin, high sensitive C-reactive protein (hsCRP) and type 2 diabetes mellitus (Corrected R2 = 0.262, p < 0.0001), while in women, type 2 diabetes mellitus is a single strong predictor for CABG, excluding EATV Index (Corrected R2 = 0.266, p = 0.005). Our study found that multiple risk factors, including epicardial adipose tissue volume and traditional ASCVD factors are determinants for CABG in men, but type 2 diabetes mellitus was the sole determinant in women. Gender-specific disparities in risk factors of CABG prompt us to evaluate new diagnostic and treatment strategies and to seek underlying mechanisms.
(徳島大学機関リポジトリ): ● Metadata: 112321
(出版サイトへのリンク): ● Publication site (DOI): 10.1371/journal.pone.0177170
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28594865; ● Summary page in Scopus @ Elsevier: 2-s2.0-85020391442

(徳島大学機関リポジトリ: 112321, DOI: 10.1371/journal.pone.0177170, PubMed: 28594865, Elsevier: Scopus) S Bando, Takeshi Soeki, Tomomi Matsuura, Takeshi Tobiume, Takayuki Ise, Kenya Kusunose, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro, Naoki Muguruma, Tetsuji Takayama, I Kishimoto, Kenji Kangawa and Masataka Sata :
Plasma brain natriuretic peptide levels are elevated in patients with cancer,
PLoS ONE, Vol.12, No.6, e0178607, 2017.

(要約): Natriuretic peptides have been proposed as biomarkers of cardiovascular disease, especially heart failure. Brain natriuretic peptide (BNP) has also been shown to be upregulated at the transcriptional and translational levels by pro-inflammatory cytokines in cardiac myocytes. Although we often measure plasma BNP levels in cancer patients, it remains unknown whether cancer-related inflammation affects the plasma BNP levels. We investigated the relationship between the BNP and human cancers. We retrospectively studied 2,923 patients in whom the plasma BNP levels and serum C-reactive protein (CRP) were measured and echocardiography was performed. Patients with clinically evident heart failure (NYHA II or higher), heart disease requiring medical treatment or surgery, renal dysfunction, and inflammatory disease were excluded. There were 234 patients in the final analysis. Blood sampling was performed before surgery and chemotherapy. In addition, we evaluated the relationship between the inflammation and plasma BNP levels in mouse models of colon cancer. Of the 234 patients, 80 were diagnosed with cancer. Both the plasma BNP and serum CRP levels were significantly higher in cancer patients than those without. There were no significant differences in the echocardiographic parameters. There was a significant positive correlation between the plasma BNP and serum CRP levels in cancer patients (r = 0.360, P<0.01) but not in those without. In cancer patients, only the CRP correlated with the BNP independent of the age, creatinine level, hypertension, and body mass index. In addition, in nude mice with subcutaneous colon cancer, the plasma BNP level was elevated compared with that in non-cancer mice, and there was a significant relationship between the plasma BNP and serum levels of the inflammatory markers. In cancer patients, as well as colon cancer model mice, the plasma BNP levels were elevated, possibly due to cancer-related inflammation. The effect of cancer on the BNP levels should be considered when using BNP as an indicator of heart failure in cancer patients.
(徳島大学機関リポジトリ): ● Metadata: 112318
(出版サイトへのリンク): ● Publication site (DOI): 10.1371/journal.pone.0178607
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28570595; ● Search Scopus @ Elsevier (PMID): 28570595; ● Search Scopus @ Elsevier (DOI): 10.1371/journal.pone.0178607

(徳島大学機関リポジトリ: 112318, DOI: 10.1371/journal.pone.0178607, PubMed: 28570595) Hirotsugu Yamada, Atsushi Tanaka, Kenya Kusunose, Rie Amano, Munehide Matsuhisa, Hiroyuki Daida, Masaaki Ito, Hiroyuki Tsutsui, Mamoru Nanasato, Haruo Kamiya, K Yasuko Bando, Masato Odawara, Hisako Yoshida, Toyoaki Murohara, Masataka Sata and Koichi Node :
Effect of sitagliptin on the echocardiographic parameters of left ventricular diastolic function in patients with type 2 diabetes: a subgroup analysis of the PROLOGUE study.,
Cardiovascular Diabetology, Vol.16, No.1, 63, 2017.

(要約): Adding sitagliptin to conventional antidiabetic regimens in patients with T2DM for 24 months attenuated the annual exacerbation in the echocardiographic parameter of diastolic dysfunction (E/e') independent of other clinical variables such as blood pressure and glycemic control. Trial registration UMIN000004490 (University Hospital Medical Information Network Clinical Trials). https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000005356 ; registered November 1, 2010.
(徳島大学機関リポジトリ): ● Metadata: 114509
(出版サイトへのリンク): ● Publication site (DOI): 10.1186/s12933-017-0546-2
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28490337; ● Search Scopus @ Elsevier (PMID): 28490337; ● Search Scopus @ Elsevier (DOI): 10.1186/s12933-017-0546-2

(徳島大学機関リポジトリ: 114509, DOI: 10.1186/s12933-017-0546-2, PubMed: 28490337) Kenya Kusunose, Yuta Torii, Hirotsugu Yamada, Susumu Nishio, Yukina Hirata, Hiromitsu Seno, Yoshihito Saijo, Takayuki Ise, Koji Yamaguchi, Takeshi Tobiume, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Clinical Utility of Longitudinal Strain to Predict Functional Recovery in Patients With Tachyarrhythmia and Reduced LVEF.,
JACC. Cardiovascular Imaging, Vol.10, No.2, 118-126, 2017.

(要約): Objectives: The aim of this study was to assess the time course of presumptive TIC and the predictors of LV functional recovery in such patients.Background: Tachycardia-induced cardiomyopathy (TIC) is a potentially reversible cardiomyopathy with effective treatment of the tachyarrhythmia. However, cases without improvement of left ventricular (LV) systolic function were found occasionally. The diagnosis of TIC can be challenging, and the role of echocardiographic imaging in the prediction of LV functional recovery is limited.Methods: LV segmental longitudinal strains (LS) were evaluated by 2-dimensional speckle tracking in 71 consecutive patients (65±16 years; 61% men) with tachyarrhythmia and reduced LV ejection fraction (EF) without any other known cardiovascular disease, and 30 age and gender matched control subjects. Relative apical LS ratio (RALSR) was defined using the equation: average apical LS / (average basal LS + average mid LS) as a marker of strain distribution.Results: Compared to control subjects, patients with tachyarrhythmia had significantly lower global LS. Improvement in LVEF within 6 months after treatment of index arrhythmia was observed in 41 patients, and LVEF did not improve in 30 patients. In univariate analysis, lower LVEF at baseline (hazard ratio: HR: 0.59 per 1SD, p=0.04) and higher RALSR (HR: 11.2 per 1SD, p <0.001) were associated with no recovery in LVEF during follow-up. In a multivariate logistic regression model, the significant predictor of LV systolic functional recovery was RALSR (HR: 22.9 per 1SD, p=0.001). A RALSR of 0.61 was sensitive (71%) and specific (90%) in differentiating LV systolic functional recovery (area under the curve: 0.88).Conclusions: The RALSR was associated with LV systolic functional recovery. This information might be useful for clinical evaluation and follow-up in patients with reduced LVEF.
(キーワード): tachycardia induced cardiomyopathy / strain imaging / functional recovery
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jcmg.2016.03.019
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27665160; ● Summary page in Scopus @ Elsevier: 2-s2.0-84994494325

(DOI: 10.1016/j.jcmg.2016.03.019, PubMed: 27665160, Elsevier: Scopus) 阿部美保, 山田博胤 :
機能性僧帽弁逆流の診断,
心エコー 2017, Vol.18, No.11, 1092-1099, 2017年. 西尾進, 山田博胤 :
経食道心エコー検査においてソノグラファーが果たす役割,
心エコー 2017, Vol.18, No.10, 934-941, 2017年. 西條良仁, 山田博胤 :
HFpEFはなぜ重要?,
心エコー 2017, Vol.18, No.7, 640-650, 2017年. 山田博胤, 西條良仁 :
心エコー図の有用性,
Pulmonary Hypertension Update 2017, Vol.3, No.2, 80-86, 2017年.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1520291856212393984

(CiNii: 1520291856212393984) 鳥居裕太, 西尾進, 松本力三, 平田有紀奈, 天野里江, 山尾雅美, 楠瀬賢也, 山田博胤, 佐田政隆 :
超音波検査が診断に有用であった右5指動静脈奇形の1例,
超音波検査技術, Vol.42, No.6, 726, 2017年. Hirofumi Tomiyama, Takashi Miwa, Kenshi Kan, Munehide Matsuhisa, Haruo Kamiya, Mamoru Nanasato, Tomoki Kitano, Hiroaki Sano, Jun Ohno, Masato Iida, Masataka Sata, Hirotsugu Yamada, Koji Maemura, Atsushi Tanaka, Toyoaki Murohara and Koichi Node :
Impact of glycemic control with sitagliptin on the 2-year progression of arterial stiffness: a sub-analysis of the PROLOGUE study.,
Cardiovascular Diabetology, Vol.15, No.1, 150, 2016.

(要約): No conclusive evidence has been obtained yet on the significance of the effects of dipeptidyl peptidase-4 (DPP-4 inhibitor) treatment on the arterial stiffness in clinical settings. In addition, the effects of good glycemic control on the arterial stiffness have also not been clarified yet. As a sub-analysis of the PROLOGUE study, we examined the effect of a DPP-4 inhibitor (sitagliptin) on the 2-year progression of the arterial stiffness and also to determine the effect of good glycemic control on the rate of progression of the arterial stiffness. In the PROLOGUE study, the study participants were either allocated to add-on sitagliptin treatment or to continued treatment with conventional anti-diabetic agents. Among the 463 participants of the PROLOGUE study, we succeeded in measuring the brachial-ankle pulse wave velocity (baPWV) at least two times during the 2-year study period in 96 subjects. The changes in the baPWV during the study period were similar between the both groups (i.e., with/without staglipitin), overall. On the other hand, when the study subjects were divided into two groups according to the glycemic control status during the study period {good glycemic control group (GC) = hemoglobin (Hb)A1c <7.0 at both 12 and 24 months after the treatment randomization; poor glycemic control group (PC) = HbA1c ≥7.0 at either 12 months, 24 months, or both}, the 2-year increase of the baPWV was marginally significantly larger in the PC group (144 ± 235 cm/s) as compared to that the GC group (-10 ± 282 cm/s) (p = 0.036). While the present study could not confirm the beneficial effect of sitagliptin per se on the arterial stiffness, the results suggested that good glycemic control appears to be beneficial for delaying the annual progression of the arterial stiffness. Trial registration University Hospital Medical Information Network Clinical Trials Registry UMIN000004490.
(徳島大学機関リポジトリ): ● Metadata: 114508
(出版サイトへのリンク): ● Publication site (DOI): 10.1186/s12933-016-0472-8
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27809848; ● Summary page in Scopus @ Elsevier: 2-s2.0-84994050554

(徳島大学機関リポジトリ: 114508, DOI: 10.1186/s12933-016-0472-8, PubMed: 27809848, Elsevier: Scopus) A Takashima, Shusuke Yagi, Koji Yamaguchi, S Watanabe, N Yamamoto, H Ito, M Kadota, T Hara, H Yamazaki, Takayuki Ise, Kenya Kusunose, Takeshi Tobiume, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Purulent pericarditis accompanying pericardial abscess induced by nocardia in an immunocompromised patient.,
Circulation Journal, Vol.80, No.11, 2409-2411, 2016.

(キーワード): Abscess / Aged, 80 and over / Echocardiography / Female / Humans / Immunocompromised Host / Nocardia / Nocardia Infections / Pericarditis / Pericardium / Tomography, X-Ray Computed
(出版サイトへのリンク): ● Publication site (DOI): 10.1253/circj.CJ-16-0531
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27628220; ● Summary page in Scopus @ Elsevier: 2-s2.0-84992462594

(DOI: 10.1253/circj.CJ-16-0531, PubMed: 27628220, Elsevier: Scopus) A Takashima, Daiju Fukuda, K Tanaka, Y Higashikuni, Y Hirata, S Nishimoto, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Yutaka Taketani, Michio Shimabukuro and Masataka Sata :
Combination of n-3 polyunsaturated fatty acids reduces atherogenesis in apolipoprotein E-deficient mice by inhibiting macrophage activation.,
Atherosclerosis, Vol.254, 142-150, 2016.

(要約): BACKGROUND AND AIMS: Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are major components of n-3 polyunsaturated fatty acids (n-3 PUFAs) which inhibit atherogenesis, although few studies have examined the effects of the combination of EPA and DHA on atherogenesis. The aim of this study was to investigate whether DHA has additional anti-atherosclerotic effects when combined with EPA.METHODS: Male 8-week-old apolipoprotein E-deficient (Apoe-/-) mice were fed a western-type diet supplemented with different amounts of EPA and DHA; EPA (2.5%, w/w), low-dose EPA + DHA (2.5%, w/w), or high-dose EPA + DHA (5%, w/w) for 20 weeks. The control group was fed a western-type diet containing no n-3 PUFA. Histological and gene expression analysis were performed in atherosclerotic lesions in the aorta. To address the mechanisms, RAW264.7 cells were used.RESULTS: All n-3 PUFA treatments significantly attenuated the development and destabilization of atherosclerotic plaques compared with the control. The anti-atherosclerotic effects were enhanced in the high-dose EPA + DHA group (p < 0.001), whereas the pure EPA group and low-dose EPA + DHA group showed similar results. EPA and DHA additively attenuated the expression of inflammatory molecules in RAW264.7 cells stimulated with LPS. DHA or EPA + DHA suppressed LPS-induced toll-like receptor 4 (TLR4) expression in lipid rafts on RAW264.7 cells (p < 0.05). Lipid raft disruption by methyl--cyclodextrin suppressed mRNA expression of inflammatory molecules in LPS-stimulated macrophages.CONCLUSION: n-3 PUFAs suppressed atherogenesis. DHA combined with EPA had additional anti-inflammatory effects and inhibited atherogenesis in Apoe-/- mice. The reduction of TLR4 expression in lipid rafts in macrophages by DHA might be involved in this mechanism, at least partially.
(キーワード): Atherosclerosis / Inflammation / Lipid raft / Macrophage / Toll-like receptor 4 / n-3 poly unsaturated fatty acid
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.atherosclerosis.2016.10.002
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27744130; ● Summary page in Scopus @ Elsevier: 2-s2.0-84991678518

(DOI: 10.1016/j.atherosclerosis.2016.10.002, PubMed: 27744130, Elsevier: Scopus) 鳥居裕太, 西尾進, 玉井佑里恵, 山崎宙, 髙尾正一郎, 楠瀬賢也, 山口浩司, 若槻哲三, 山田博胤, 佐田政隆 :
解剖学的異常を認めない膝窩動脈捕捉症候群の1例,
超音波検査技術, Vol.41, No.5, 513-520, 2016年.

(出版サイトへのリンク): ● Publication site (DOI): 10.11272/jss.41.513
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390001205281332224; ● Search Scopus @ Elsevier (DOI): 10.11272/jss.41.513

(DOI: 10.11272/jss.41.513, CiNii: 1390001205281332224) Tatsuya Maruhashi, Yukihito Higashi, Yasuki Kihara, Hirotsugu Yamada, Masataka Sata, Shinichiro Ueda, Masato Odawara, Yasuo Terauchi, Kazuoki Dai, Jun Ohno, Masato Iida, Hiroaki Sano, Hirofumi Tomiyama, Teruo Inoue, Atsushi Tanaka, Toyoaki Murohara and Koichi Node :
Long-term effect of sitagliptin on endothelial function in type 2 diabetes: a sub-analysis of the PROLOGUE study.,
Cardiovascular Diabetology, Vol.15, No.1, 134, 2016.

(要約): As a sub-analysis of the PROLOGUE study, we evaluated the long-term effect of sitagliptin, a dipeptidyl peptidase 4 inhibitor, on endothelial function in the conduit brachial artery in patients with type 2 diabetes. In the PROLOGUE study, patients were randomly assigned to either add-on sitagliptin treatment (sitagliptin group) or continued conventional antihyperglycemic treatment (conventional group). Among the 463 participants in the PROLOGUE study, FMD was measured in 17 patients in the sitagliptin group and 18 patients in the conventional group at the beginning and after 12 and 24 months of treatment. HbA1c levels were significantly decreased after 12 and 24 months of treatment compared to baseline values in both groups (7.0 0.4 vs. 6.6 0.3 and 6.6 0.4 % in the sitagliptin group; 7.0 0.6 vs. 6.6 0.7 and 6.6 0.7 % in the conventional group; P < 0.05, respectively). There was no significant difference between FMD values at baseline and after 12 and 24 months in the sitagliptin group (4.3 2.6 vs. 4.4 2.1 and 4.4 2.3 %, P = 1.0, respectively). Although FMD had a tendency to increase from 4.3 2.4 % at baseline to 5.2 1.9 % after 12 months and 5.1 2.2 % after 24 months in the conventional group, there was no significant difference between FMD values at baseline and after 12 and 24 months (P = 0.36 and 0.33, respectively). Add-on sitagliptin to conventional antihyperglycemic drugs in patients with type 2 diabetes did not alter endothelial function in the conduit brachial artery measured by FMD during a 2-year study period. Sitagliptin may be used without concern for an adverse effect on endothelial function in patients with type 2 diabetes. University hospital Medical Information Network (UMIN) Center: ID UMIN000004490.
(キーワード): Aged / Biomarkers / Blood Glucose / Brachial Artery / Diabetes Mellitus, Type 2 / Dipeptidyl-Peptidase IV Inhibitors / Drug Therapy, Combination / Endothelium, Vascular / Female / Glycated Hemoglobin A / Humans / 日本 (Japan) / Male / Middle Aged / Prospective Studies / Sitagliptin Phosphate / Time Factors / Treatment Outcome / Vasodilation
(徳島大学機関リポジトリ): ● Metadata: 114511
(出版サイトへのリンク): ● Publication site (DOI): 10.1186/s12933-016-0438-x
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27624168; ● Summary page in Scopus @ Elsevier: 2-s2.0-84992361845

(徳島大学機関リポジトリ: 114511, DOI: 10.1186/s12933-016-0438-x, PubMed: 27624168, Elsevier: Scopus) A Tanaka, T Murohara, I Taguchi, K Eguchi, M Suzuki, M Kitakaze, Y Sato, T Ishizu, Y Higashi, Hirotsugu Yamada, M Nanasato, Michio Shimabukuro, H Teragawa, S Ueda, S Kodera, Munehide Matsuhisa, T Kadokami, K Kario, Y Nishio, T Inoue, K Maemura, J Oyama, M Ohishi, Masataka Sata, H Tomiyama, K Node and Investigators Study PROTECT :
Rationale and design of a multicenter randomized controlled study to evaluate the preventive effect of ipragliflozin on carotid atherosclerosis: the PROTECT study.,
Cardiovascular Diabetology, Vol.15, No.1, 133, 2016.

(要約): BACKGROUND: Type 2 diabetes mellitus is associated strongly with an increased risk of micro- and macro-vascular complications, leading to impaired quality of life and shortened life expectancy. In addition to appropriate glycemic control, multi-factorial intervention for a wide range of risk factors, such as hypertension and dyslipidemia, is crucial for management of diabetes. A recent cardiovascular outcome trial in diabetes patients with higher cardiovascular risk demonstrated that a SGLT2 inhibitor markedly reduced mortality, but not macro-vascular events. However, to date there is no clinical evidence regarding the therapeutic effects of SGLT2 inhibitors on arteriosclerosis. The ongoing PROTECT trial was designed to assess whether the SGLT2 inhibitors, ipragliflozin, prevented progression of carotid intima-media thickness in Japanese patients with type 2 diabetes mellitus.METHODS: A total of 480 participants with type 2 diabetes mellitus with a HbA1c between 6 and 10 % despite receiving diet/exercise therapy and/or standard anti-diabetic agents for at least 3 months, will be randomized systematically (1:1) into either ipragliflozin or control (continuation of conventional therapy) groups. After randomization, ipragliflozin (50-100 mg once daily) will be added on to the background therapy in participants assigned to the ipragliflozin group. The primary endpoint of the study is the change in mean intima-media thickness of the common carotid artery from baseline to 24 months. Images of carotid intima-media thickness will be analyzed at a central core laboratory in a blinded manner. The key secondary endpoints include the change from baseline in other parameters of carotid intima-media thickness, various metabolic parameters, and renal function. Other cardiovascular functional tests are also planned for several sub-studies.DISCUSSION: The PROTECT study is the first to assess the preventive effect of ipragliflozin on progression of carotid atherosclerosis using carotid intima-media thickness as a surrogate marker. The study has potential to clarify the protective effects of ipragliflozin on atherosclerosis. Trial registration Unique Trial Number, UMIN000018440 ( https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000021348 ).
(キーワード): Adult / Aged / Biomarkers / Carotid Artery Diseases / Carotid Artery, Common / Carotid Intima-Media Thickness / Clinical Protocols / Diabetes Mellitus, Type 2 / Diabetic Angiopathies / Drug Therapy, Combination / Female / Glucosides / Hemoglobin A, Glycosylated / Humans / Hypoglycemic Agents / Japan / Male / Middle Aged / Prospective Studies / Research Design / Sodium-Glucose Transporter 2 / Thiophenes / Time Factors / Treatment Outcome / Young Adult
(徳島大学機関リポジトリ): ● Metadata: 114507
(出版サイトへのリンク): ● Publication site (DOI): 10.1186/s12933-016-0449-7
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27619983; ● Search Scopus @ Elsevier (PMID): 27619983; ● Search Scopus @ Elsevier (DOI): 10.1186/s12933-016-0449-7

(徳島大学機関リポジトリ: 114507, DOI: 10.1186/s12933-016-0449-7, PubMed: 27619983) M Kadota, Takayuki Ise, Shusuke Yagi, Takashi Iwase, Masashi Akaike, R Ueno, Y Kawabata, T Hara, K Ogasawara, Mika Bando, S Bando, Tomomi Matsuura, Koji Yamaguchi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Response prediction and influence of tolvaptan in chronic heart failure patients considering the interaction of the renin-angiotensin-aldosterone system and arginine vasopressin.,
International Heart Journal, Vol.57, No.4, 461-465, 2016.

(要約): The renin-angiotensin-aldosterone system (RAAS) and arginine vasopressin (AVP) regulate body fluids. Although conventional diuretics have been used for treating heart failure, they activate RAAS and exacerbate renal function. Tolvaptan, a newly developed vasopressin-2 receptor antagonist, elicits aquaresis and improves volume overload in heart failure patients, however, the predictors of tolvaptan effectiveness and the influence on the RAAS and renal function according to tolvaptan therapy are not established. We evaluated 26 chronic heart failure patients receiving therapy with 15 mg/day tolvaptan and examined their laboratory and urinary data before and after tolvaptan therapy. A response to tolvaptan was defined as a body weight decrease by more than 2 kg in a week and a urine volume increase by 500 mL/ day compared with that before tolvaptan administration. Body weight, urine volume, and brain natriuretic peptide levels significantly improved (P < 0.05), without any worsening of renal function represented by serum creatinine, sodium, and potassium. Moreover, no significant changes were observed in the plasma renin activity and plasma aldosterone concentration (PAC). In the responder group, urine osmolality before tolvaptan administration was significantly higher (P < 0.05) but declined significantly after tolvaptan administration (P < 0.05). The AVP/PAC ratio before administration was positively correlated with the efficacy of tolvaptan. Tolvaptan treatment could prevent RAAS activation in chronic heart failure patients. Moreover, monitoring the AVP/PAC ratio may be useful in predicting the tolvaptan response.
(キーワード): Adult / Aged / Aged, 80 and over / Antidiuretic Hormone Receptor Antagonists / Arginine Vasopressin / Benzazepines / Body Mass Index / Female / Heart Failure / Humans / Male / Middle Aged / Prospective Studies / Renin-Angiotensin System / Treatment Outcome
(徳島大学機関リポジトリ): ● Metadata: 109694
(出版サイトへのリンク): ● Publication site (DOI): 10.1536/ihj.15-491
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27357439; ● Summary page in Scopus @ Elsevier: 2-s2.0-84979587993

(徳島大学機関リポジトリ: 109694, DOI: 10.1536/ihj.15-491, PubMed: 27357439, Elsevier: Scopus) 山田博胤, 田中秀和, 宮原俊介, 尾形竜郎, 楠瀬賢也, 西尾進, 鳥居裕太, 平田有紀奈, 大北裕, 佐田政隆 :
表在エコー図検査と心エコー図検査のコラボレーションにより感染性心内膜炎が迅速に診断できた僧帽弁逸脱症の1例:Staphylococcus warneriによる自己弁への感染性心内膜炎,
超音波医学, Vol.43, No.4, 581-586, 2016年.

(要約): 症例は，46歳男性，循環器内科医師，主訴は左足関節内果部と上腕の疼痛である．僧帽弁逸脱症による僧帽弁逆流と発作性心房細動の既往がある．足関節の疼痛は蜂窩織炎を疑って，血液検査と表在エコー図検査を行った．疼痛部は皮下浮腫が著明であったが，軟部組織の血流シグナルが乏しく，後脛骨動脈の血管壁を主体とした炎症と，同動脈の閉塞が確認された．一方，左手関節近位の尺骨動脈は逆行性血流を示しており，左尺骨動脈分岐部直後で閉塞していた．これらの所見から多発性血管閉塞性動脈炎と診断し，その原因究明のために直ちに心エコー図検査を施行した．その結果，僧帽弁に可動性を有する棍棒状の異常構造物を認め，僧帽弁逆流は高度に増悪しており，感染性心内膜炎と診断された．頭部MRI検査で異常を認めなかったため，外科的加療(疣腫摘除術，僧帽弁形成術，左房縫縮術，左心耳閉鎖術，Maze手術)が行われた．血液培養は陰性であったが，摘出した疣腫の培養からStaphylococcus warneriが同定された．Staphylococcus warneriは皮膚常在菌であり，本病原体による自己弁の感染性心内膜炎は報告が少ない．術後の経過は良好であり，抗生剤を6週間静脈投与した後に社会復帰した．患者が循環器内科医であり，自身の足関節および上腕の疼痛を契機に，表在エコー図検査と心エコー図検査を用いることで，感染性心内膜炎を迅速に診断した稀有な症例であり，かつ，感染性心内膜炎の起炎菌としては稀なStaphylococcus warneriが同定されたので，文献的な考察を加えて報告する．
(出版サイトへのリンク): ● Publication site (DOI): 10.3179/jjmu.JJMU.A.63
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.3179/jjmu.JJMU.A.63

(DOI: 10.3179/jjmu.JJMU.A.63) J Oyama, T Murohara, M Kitakaze, T Ishizu, Y Sato, K Kitagawa, H Kamiya, M Ajioka, M Ishiara, K Dai, M Nanasato, Masataka Sata, K Maemura, H Tomiyama, Y Higashi, K Kaku, Hirotsugu Yamada, Munehide Matsuhisa, K Yamashita, YK Bando, N Kashihara, S Ueda, T Inoue, K Node and Investigators Study PROLOGUE :
The Effect of Sitagliptin on Carotid Artery Atherosclerosis in Type 2 Diabetes: The PROLOGUE Randomized Controlled Trial.,
PLoS Medicine, Vol.13, No.6, e1002051, 2016.

(要約): BACKGROUND: Experimental studies have suggested that dipeptidyl peptidase-4 (DPP-4) inhibitors provide cardiovascular protective effects. We performed a randomized study to evaluate the effects of sitagliptin added on to the conventional therapy compared with conventional therapy alone (diet, exercise, and/or drugs, except for incretin-related agents) on the intima-media thickness (IMT) of the carotid artery, a surrogate marker for the evaluation of atherosclerotic cardiovascular disease, in people with type 2 diabetes mellitus (T2DM).METHODS AND FINDINGS: We used a multicenter PROBE (prospective, randomized, open label, blinded endpoint) design. Individuals aged 30 y with T2DM (6.2% HbA1c < 9.4%) were randomly allocated to receive either sitagliptin (25 to 100 mg/d) or conventional therapy. Carotid ultrasound was performed at participating medical centers, and all parameters were measured in a core laboratory. Of the 463 enrolled participants with T2DM, 442 were included in the primary analysis (sitagliptin group, 222; conventional therapy group, 220). Estimated mean (± standard error) common carotid artery IMT at 24 mo of follow-up in the sitagliptin and conventional therapy groups was 0.827 ± 0.007 mm and 0.837 ± 0.007 mm, respectively, with a mean difference of -0.009 mm (97.2% CI -0.028 to 0.011, p = 0.309). HbA1c level at 24 mo was significantly lower with sitagliptin than with conventional therapy (6.56% ± 0.05% versus 6.72% ± 0.05%, p = 0.008; group mean difference -0.159, 95% CI -0.278 to -0.041). Episodes of serious hypoglycemia were recorded only in the conventional therapy group, and the rate of other adverse events was not different between the two groups. As it was not a placebo-controlled trial and carotid IMT was measured as a surrogate marker of atherosclerosis, there were some limitations of interpretation.CONCLUSIONS: In the PROLOGUE study, there was no evidence that treatment with sitagliptin had an additional effect on the progression of carotid IMT in participants with T2DM beyond that achieved with conventional treatment.TRIAL REGISTRATION: University Hospital Medical Information Network Clinical Trials Registry UMIN000004490.
(徳島大学機関リポジトリ): ● Metadata: 114321
(出版サイトへのリンク): ● Publication site (DOI): 10.1371/journal.pmed.1002051
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27351380; ● Search Scopus @ Elsevier (PMID): 27351380; ● Search Scopus @ Elsevier (DOI): 10.1371/journal.pmed.1002051

(徳島大学機関リポジトリ: 114321, DOI: 10.1371/journal.pmed.1002051, PubMed: 27351380) Jun-Ichi Oyama, Atsushi Tanaka, Yasunori Sato, Hirofumi Tomiyama, Masataka Sata, Tomoko Ishizu, Isao Taguchi, Takanori Kuroyanagi, Hiroki Teragawa, Nobukazu Ishizaka, Yumiko Kanzaki, Mitsuru Ohishi, Kazuo Eguchi, Yukihito Higashi, Hirotsugu Yamada, Koji Maemura, Junya Ako, Yasuko K. Bando, Shinichiro Ueda, Teruo Inoue, Toyoaki Murohara and Koichi Node :
Rationale and design of a multicenter randomized study for evaluating vascular function under uric acid control using the xanthine oxidase inhibitor, febuxostat: the PRIZE study.,
Cardiovascular Diabetology, Vol.15, No.1, 87, 2016.

(要約): BACKGROUND: Xanthine oxidase inhibitors are anti-hyperuricemic drugs that decrease serum uric acid levels by inhibiting its synthesis. Xanthine oxidase is also recognized as a pivotal enzyme in the production of oxidative stress. Excess oxidative stress induces endothelial dysfunction and inflammatory reactions in vascular systems, leading to atherosclerosis. Many experimental studies have suggested that xanthine oxidase inhibitors have anti-atherosclerotic effects by decreasing in vitro and in vivo oxidative stress. However, there is only limited evidence on the clinical implications of xanthine oxidase inhibitors on atherosclerotic cardiovascular disease in patients with hyperuricemia. We designed the PRIZE study to evaluate the effects of febuxostat on a surrogate marker of cardiovascular disease risk, ultrasonography-based intima-media thickness of the carotid artery in patients with hyperuricemia.METHODS: The study is a multicenter, prospective, randomized, open-label and blinded-endpoint evaluation (PROBE) design. A total of 500 patients with asymptomatic hyperuricemia (uric acid >7.0 mg/dL) and carotid intima-media thickness 1.1 mm will be randomized centrally to receive either febuxostat (10-60 mg/day) or non-pharmacological treatment. Randomization is carried out using the dynamic allocation method stratified according to age (<65, 65 year), gender, presence or absence of diabetes mellitus, serum uric acid (<8.0, 8.0 mg/dL), and carotid intima-media thickness (<1.3, 1.3 mm). In addition to administering the study drug, we will also direct lifestyle modification in all participants, including advice on control of body weight, sleep, exercise and healthy diet. Carotid intima-media thickness will be evaluated using ultrasonography performed by skilled technicians at a central laboratory. Follow-up will be continued for 24 months. The primary endpoint is percentage change in mean intima-media thickness of the common carotid artery 24 months after baseline, measured by carotid ultrasound imaging.CONCLUSIONS: PRIZE will be the first study to provide important data on the effects of febuxostat on atherosclerosis in patients with asymptomatic hyperuricemia. Trial Registration Unique trial Number, UMIN000012911 ( https://upload.umin.ac.jp/cgi-open-bin/ctr/ctr.cgi?function=brows&action=brows&type=summary&recptno=R000015081&language=E ).
(キーワード): 頸動脈 (carotid artery) / Febuxostat / Hyperuricemia / Intima-media thickness (IMT) / Xanthine oxidase inhibitor
(徳島大学機関リポジトリ): ● Metadata: 114506
(出版サイトへのリンク): ● Publication site (DOI): 10.1186/s12933-016-0409-2
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27317093; ● Summary page in Scopus @ Elsevier: 2-s2.0-84975229374

(徳島大学機関リポジトリ: 114506, DOI: 10.1186/s12933-016-0409-2, PubMed: 27317093, Elsevier: Scopus) M Akaishi, T Asanuma, C Izumi, S Iwanaga, H Kawai, M Daimon, H Toide, S Hashimoto, A Hayashida, Hirotsugu Yamada and S Nakatani :
Guidelines for conducting transesophageal echocardiography (TEE) : Task force for guidelines for conducting TEE.,
Journal of Echocardiography, Vol.14, No.2, 47-48, 2016.

(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s12574-016-0281-9
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26894387; ● Search Scopus @ Elsevier (PMID): 26894387; ● Search Scopus @ Elsevier (DOI): 10.1007/s12574-016-0281-9

(DOI: 10.1007/s12574-016-0281-9, PubMed: 26894387) Michio Shimabukuro, C Okawa, Hirotsugu Yamada, S Yanagi, E Uematsu, N Sugasawa, Hirotsugu Kurobe, Y Hirata, JR Kim-Kaneyama, XF Lei, S Takao, Y Tanaka, Daiju Fukuda, Shusuke Yagi, Takeshi Soeki, Tetsuya Kitagawa, H Masuzaki, M Sato and Masataka Sata :
The pathophysiological role of oxidized cholesterols in epicardial fat accumulation and cardiac dysfunction: A study in swine fed a high caloric diet with an inhibitor of intestinal cholesterol absorption, ezetimibe.,
The Journal of Nutritional Biochemistry, Vol.35, 66-73, 2016.

(要約): Oxidized cholesterols (oxycholesterols) in food have been recognized as strong atherogenic components, but their tissue distributions and roles in cardiovascular diseases remain unclear. To investigate whether accumulation of oxycholesterols is linked to cardiac morphology and function, and whether reduction of oxycholesterols can improve cardiac performance, domestic male swine were randomized to a control diet (C), high caloric diet (HCD) or HCD+Ezetimibe, an inhibitor of intestinal cholesterol absorption, group (HCD+E) and evaluated for: (1) distribution of oxycholesterol components in serum and tissues, (2) levels of oxycholesterol-related enzymes, (3) paracardial and epicardial coronary fat thickness, and (4) cardiac performance. Ezetimibe treatment for 8weeks attenuated increases in oxycholesterols in the HCD group almost completely in liver, but reduced only levels of 4β-hydroxycholesterol in left ventricular (LV) myocardium. Ezetimibe treatment altered the expression of genes for cholesterol and fatty acid metabolism and decreased the expression of CYP3A46, which catabolizes cholesterol to 4β-hydroxycholesterol, strongly in liver. An increase in epicardial fat thickness and impaired cardiac performance in the HCD group were improved by ezetimibe treatment, and the improvement was closely related to the reduction in levels of 4β-hydroxycholesterol in LV myocardium. In conclusion, an increase in oxycholesterols in the HCD group was closely related to cardiac hypertrophy and dysfunction, as well as an increase in epicardial fat thickness. Ezetimibe may directly reduce oxycholesterol in liver and LV myocardium, and improve cardiac morphology and function.
(キーワード): Cardiac function / Cardiac hypertrophy / Epicardial fat / Obesity / Oxycholesterol
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jnutbio.2016.05.010
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27416363; ● Search Scopus @ Elsevier (PMID): 27416363; ● Search Scopus @ Elsevier (DOI): 10.1016/j.jnutbio.2016.05.010

(DOI: 10.1016/j.jnutbio.2016.05.010, PubMed: 27416363) Mika Bando, Hirotsugu Yamada, Kenya Kusunose, Daiju Fukuda, Rie Amano, Rina Tamai, Yuta Torii, Yukina Hirata, Susumu Nishio, Junichiro Satomi, Shinji Nagahiro and Masataka Sata :
Noninvasive quantitative tissue characterization of carotid plaque using color-coded mapping based on ultrasound integrated backscatter.,
JACC. Cardiovascular Imaging, Vol.9, No.5, 625-627, 2016.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jcmg.2015.02.017
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26093930; ● Summary page in Scopus @ Elsevier: 2-s2.0-84931059223

(DOI: 10.1016/j.jcmg.2015.02.017, PubMed: 26093930, Elsevier: Scopus) Kenya Kusunose and Hirotsugu Yamada :
Noninvasive Vascular Function Tests - Long Journey for Predicting Cardiovascular Events.,
Circulation Journal, Vol.80, No.6, 1321-1322, 2016.

(キーワード): Acute Coronary Syndrome / Brachial Artery / Cardiovascular Diseases / Diagnostic Techniques, Cardiovascular / Humans / Predictive Value of Tests / Risk Factors / Vascular Stiffness
(出版サイトへのリンク): ● Publication site (DOI): 10.1253/circj.CJ-16-0356
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27151336; ● Summary page in Scopus @ Elsevier: 2-s2.0-84969638887

(DOI: 10.1253/circj.CJ-16-0356, PubMed: 27151336, Elsevier: Scopus) T Hayashi, S Yamada, H Iwano, M Nakabachi, M Sakakibara, K Okada, D Murai, H Nishino, Kenya Kusunose, K Watanabe, T Ishizu, K Wakami, Hirotsugu Yamada, K Dohi, Y Seo, N Ohte, T Mikami and H Tsutsui :
Left Ventricular Global Strain for Estimating Relaxation and Filling Pressure- A Multicenter Study.,
Circulation Journal, Vol.80, No.5, 1163-1170, 2016.

(要約): BACKGROUND: Speckle-tracking echocardiography (STE)-derived parameters may have better correlation with left ventricular (LV) relaxation and filling pressure than tissue Doppler-derived parameters. However, it has not been elucidated which parameter - strain or strain rate - and which direction of myocardial deformation - longitudinal or circumferential - is the most useful marker of LV relaxation and filling pressure.METHODSANDRESULTS: We conducted a prospective multicenter study and compared the correlation of tissue Doppler- and STE-derived parameters with the time constant of LV pressure decay () and LV mean diastolic pressure (MDP) in 77 patients. The correlation of early-diastolic mitral annular velocity (e´) with was weak (r=-0.32, P<0.01), and that of peak longitudinal strain (LS) was the strongest (r=-0.45, P<0.001) among the STE-derived parameters. There was a modest correlation between LVMDP and the ratio of early-diastolic inflow velocity (E) to e´ (E/e´) (r=0.50, P<0.001). In contrast, the ratio of E to LS (E/LS) correlated strongly with LVMDP (r=0.70, P<0.001). The correlation of E/LS with LVMDP was significantly better than that for E/e´ (P<0.01). Receiver-operating characteristic analysis showed that E/LS had the largest area under the curve for distinguishing elevated LVMDP (E/LS 0.86, E/e´ 0.74, E/A 0.67).CONCLUSIONS: STE-derived longitudinal parameters correlated well with LV relaxation and filling pressure. In particular, E/LS could be more accurate than E/e´ for estimating LV filling pressure. (Circ J 2016; 80: 1163-1170).
(出版サイトへのリンク): ● Publication site (DOI): 10.1253/circj.CJ-16-0106
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27021934; ● Search Scopus @ Elsevier (PMID): 27021934; ● Search Scopus @ Elsevier (DOI): 10.1253/circj.CJ-16-0106

(DOI: 10.1253/circj.CJ-16-0106, PubMed: 27021934) Kenya Kusunose, M Sato, Hirotsugu Yamada, Y Saijo, Mika Bando, Y Hirata, S Nishio, S Hayashi and Masataka Sata :
Prognostic implications of non-invasive vascular function tests in high-risk atherosclerosis patients.,
Circulation Journal, Vol.80, No.4, 1034-1040, 2016.

(要約): BACKGROUND: The aim of this study was to assess the role of clinically available vascular function tests as predictors of cardiovascular events and decline in kidney function.MethodsandResults:One hundred and fourteen patients who had at least 2 cardiovascular risk factors were recruited for vascular function assessment including ankle-brachial blood pressure index (ABI), brachial-ankle pulse wave velocity (baPWV), cardio-ankle vascular index (CAVI) and flow-mediated vasodilatation (%FMD). During a median period of 51 months, 35 patients reached the primary endpoint (29 cardiovascular events and 6 cardiac deaths), and 30 patients reached the secondary endpoint (decline in kidney function: defined as a 5% per year decline of estimated glomerular filtration rate). In sequential Cox models, a model on the basis of the Framingham risk score, hemoglobin, and high-sensitivity C-reactive protein (chi-squared, 16.6) was improved by the ABI (chi-squared: 21.5; P=0.047). The baPWV (hazard ratio: 1.42 per 1 SD increase; P=0.025) and the CAVI (hazard ratio: 1.52 per 1 SD increase; P=0.040) were associated with the secondary endpoint. The %FMD was only slightly associated with the primary and secondary endpoints.CONCLUSIONS: Both ABI and baPWV are significantly associated with future cardiovascular events in high-risk patients with cardiovascular disease. The predictive capabilities of these parameters are greater than that of other parameters in this cohort.
(キーワード): Cardiovascular event / Endothelial function / Kidney function / Vascular function
(出版サイトへのリンク): ● Publication site (DOI): 10.1253/circj.CJ-15-1356
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26936237; ● Summary page in Scopus @ Elsevier: 2-s2.0-84961625684

(DOI: 10.1253/circj.CJ-15-1356, PubMed: 26936237, Elsevier: Scopus) Takeshi Soeki, Tomomi Matsuura, Sachiko Bando, Takeshi Tobiume, Etsuko Uematsu, Takayuki Ise, Kenya Kusunose, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Relationship between local production of microRNA-328 and atrial substrate remodeling in atrial fibrillation.,
Journal of Cardiology, Vol.68, No.6, 472-477, 2016.

(要約): BACKGROUND: The underlying mechanism of atrial substrate remodeling in atrial fibrillation (AF) remains unknown. In this study, we investigated whether local and systemic levels of microRNA (miR) might be associated with the presence of AF and with left atrial (LA) substrate properties.METHODS: Blood from the periphery, pulmonary vein (PV), and left atrial appendage (LAA) was sampled from 30 patients with AF undergoing PV isolation, and from 10 control subjects with Wolff-Parkinson-White syndrome and without AF. We measured peripheral, PV, and LAA plasma levels of miR-1, -26, -133a, -328, and -590 by reverse transcription-polymerase chain reaction. LA global contact mapping during sinus rhythm was performed before PV isolation.RESULTS: Plasma levels of miR-328 were higher in patients with AF than in control subjects. Plasma miR-328 levels were significantly higher in the LAA than in the periphery and PV in patients with AF, but not in control subjects. Plasma miR-1 levels were also higher in the LAA than in the PV in AF patients. Interestingly, LAA plasma levels of miR-328 showed a positive correlation with the LA voltage zone index (area with voltage <0.5mV divided by total LA surface area) and a weak correlation with LA volume.CONCLUSION: Local production of miR-328 in the left atrium may be involved in the process of atrial remodeling in patients with AF.
(キーワード): Atrial fibrillation / Left atrium / MicroRNA / Remodeling / Substrate
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jjcc.2015.12.007
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26987792; ● Summary page in Scopus @ Elsevier: 2-s2.0-84960969355

(DOI: 10.1016/j.jjcc.2015.12.007, PubMed: 26987792, Elsevier: Scopus) Yuta Torii, Hirotsugu Yamada, Susumu Matsukuma, Susumu Nishio, Kenya Kusunose, Miho Abe and Masataka Sata :
Left Ventricular lipomatous hamartoma mimicking a calcified amorphous tumor.,
Circulation, Vol.133, No.8, e408-e410, 2016.

(出版サイトへのリンク): ● Publication site (DOI): 10.1161/CIRCULATIONAHA.115.019252
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26903022; ● Search Scopus @ Elsevier (PMID): 26903022; ● Search Scopus @ Elsevier (DOI): 10.1161/CIRCULATIONAHA.115.019252

(DOI: 10.1161/CIRCULATIONAHA.115.019252, PubMed: 26903022) Toshiyuki Niki, Tetsuzo Wakatsuki, Koji Yamaguchi, Yoshio Taketani, Hiroyasu Oeduka, Kenya Kusunose, Takayuki Ise, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Effects of the addition of eicosapentaenoic acid to strong statin therapy on inflammatory cytokines and coronary plaque components assessed by integrated backscatter intravascular ultrasound.,
Circulation Journal, Vol.80, No.2, 450-460, 2016.

(要約): BACKGROUND: The effects of eicosapentaenoic acid (EPA) on coronary artery disease have been previously reported; however, those of the addition of EPA to strong statins on coronary plaque components and local inflammatory cytokines are not known.METHODSANDRESULTS: A total of 95 patients who had been treated with strong statin for at least 6 months were randomized into 2 groups: an EPA group (additional treatment with EPA at 1,800 mg/day, n=48) or a control group (no additional treatment, n=47), for 6 months. The tissue characteristics of target coronary plaque in each patient were analyzed using IB-IVUS before and after treatment. We also measured plasma levels of inflammatory cytokines sampled in the coronary sinus (CS) and peripheral vein.A significant reduction in lipid volume (18.5±1.3 to 15.0±1.5 mm(3), P=0.007) and a significant increase in fibrous volume (22.9±0.8 to 25.6±1.1 mm(3), P=0.01) were observed in IB-IVUS image analyses in the EPA group, but no significant changes in the plaque components in the control group. CS levels of pentraxin 3 and monocyte chemoattractant protein-1 were lower after than before treatment with EPA (3.3±2.1 to 2.6±1.2 ng/ml, 120.4±26.2 to 110.2±26.8 pg/ml, P=0.015 and P=0.008, respectively); however, there were no significant changes in those inflammatory cytokines between pre- and post-treatment in the control group.CONCLUSIONS: The addition of EPA was associated with reduced lipid volume in coronary plaques and decreased inflammatory cytokines. (Circ J 2016; 80: 450-460).
(キーワード): Coronary plaque / Eicosapentaenoic acid / Inflammatory cytokines / Integrated backscatter intravascular ultrasound / Strong statins
(徳島大学機関リポジトリ): ● Metadata: 109653
(出版サイトへのリンク): ● Publication site (DOI): 10.1253/circj.CJ-15-0813
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26667367; ● Summary page in Scopus @ Elsevier: 2-s2.0-84955453337

(徳島大学機関リポジトリ: 109653, DOI: 10.1253/circj.CJ-15-0813, PubMed: 26667367, Elsevier: Scopus) Yuta Torii, Kenya Kusunose, Hirotsugu Yamada, Susumu Nishio, Yukina Hirata, Rie Amano, Masami Yamao, Mika Bando, Shuji Hayashi and Masataka Sata :
Comparison of tricuspid annular plane systolic excursion in patients with atrial fibrillation vs sinus rhythm.,
The American Journal of Cardiology, Vol.117, No.2, 226-232, 2016.

(要約): Echocardiography now plays a central guiding role in the management of patients with atrial fibrillation (AF). However, the current guidelines mention little about the presence AF during the assessment of echocardiographic variables in the clinical setting. AF itself may impact on tricuspid annular plane systolic excursion (TAPSE) as a right ventricular systolic function compared with sinus rhythm (SR). The aim of this study was to compare and assess the echocardiographic parameters including TAPSE in patients with AF and SR. From January 1, 2013, to September 30, 2014, patients with AF without any cardiovascular disease were retrospectively evaluated using echocardiography. Age-, gender-, and left ventricular ejection fraction-matched patients with SR were selected from our database on the basis of a comprehensive history, physical examination, and echocardiographic findings. During the study period, we identified 239 patients with AF (74 ± 9 years; 65% men) and without any cardiac disease who underwent echocardiography. We also included 281 patients in the SR group (74 ± 8 years; 67% men). In all study subjects, TAPSE in AF was smaller than in SR regardless of age (17 ± 3 vs 20 ± 3 mm, p <0.001). In the stepwise multiple regression model, TAPSE was strongly associated with the presence of AF (standardized β = -0.362, p <0.001) and stroke volume index (standardized β = 0.173, p <0.001) after adjustment for age, gender, heart rate, left ventricular ejection fraction, and tricuspid regurgitant grade. In conclusions, patients with AF had lower TAPSE than those with SR regardless of age. When we assess TAPSE in the clinical setting, we must pay attention to the presence of AF.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.amjcard.2015.10.035
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26651451; ● Summary page in Scopus @ Elsevier: 2-s2.0-84949257248

(DOI: 10.1016/j.amjcard.2015.10.035, PubMed: 26651451, Elsevier: Scopus) Akira Takashima, Shusuke Yagi, Koji Yamaguchi, Eri Takagi, Tamotsu Kanbara, Hirohisa Ogawa, Takayuki Ise, Kenya Kusunose, Takeshi Tobiume, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Tetsuya Kitagawa and Masataka Sata :
Vegetation in the coronary sinus that concealed the presence of a coronary arteriovenous fistula in a patient with infectious endocarditis.,
International Journal of Cardiology, Vol.207, 266-268, 2016.

(キーワード): Coronary sinus / Fistula / Infectious endocarditis / Vegetation
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.ijcard.2016.01.057
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26808990; ● Summary page in Scopus @ Elsevier: 2-s2.0-84958019532

(DOI: 10.1016/j.ijcard.2016.01.057, PubMed: 26808990, Elsevier: Scopus) S Hayashi, Hirotsugu Yamada, Makoto Fukui, Hiro-O Ito and Masataka Sata :
Correlation between arteriosclerosis and periodontal condition assessed by lactoferrin and [alpha]1-antitrypsin levels in gingival crevicular fluid.,
International Heart Journal, Vol.56, No.6, 639-643, 2015.

(要約): Patients with periodontal disease exhibit exacerbated atherosclerosis, aortic stiffness, or vascular endothelial dysfunction. However, in a recent scientific statement, the American Heart Association noted that neither has periodontal disease been proven to cause atherosclerotic vascular disease nor has the treatment of periodontal disease been proven to prevent atherosclerotic vascular disease. Therefore, the aim of the present study was to examine the correlation between periodontal condition and arteriosclerosis in patients with coronary artery disease (CAD), which is usually accompanied by systemic arteriosclerosis.We measured levels of gingival crevicular fluid lactoferrin (GCF-Lf) and 1-antitrypsin (GCF-AT) in 72 patients (67 ± 8 years, 56 men) with CAD. Furthermore, we evaluated the maximum intima-media thickness (max IMT) and plaque score of the carotid arteries as well as brachial-ankle pulse wave velocity (baPWV) and flow-mediated dilation (FMD) of the brachial artery, each of which is a parameter for determining arteriosclerosis status. The average level of GCF-Lf was 0.29 ± 0.36 µg/mL and that of GCF-AT was 0.31 ± 0.66 µg/mL, with significant correlation between the two (r = 0.701, P < 0.001). No significant difference in GCF-Lf and GCF-AT levels was observed between patients with single-, double-, and triple-vessel CAD. There were no significant correlations between the arteriosclerosis parameters (ie, max IMT, plaque score, baPWV, and FMD) and GCF-Lf or GCF-AT.No correlation between the GCF biomarkers and the severity of arteriosclerosis was detected. This result may suggest that worsening of the periodontal condition assessed by GCF biomarkers is not a major potential risk factor for arteriosclerosis.
(キーワード): Periodontal disease / Coronary artery disease / Atherosclerosis
(出版サイトへのリンク): ● Publication site (DOI): 10.1536/ihj.15-218
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26549390; ● Search Scopus @ Elsevier (PMID): 26549390; ● Search Scopus @ Elsevier (DOI): 10.1536/ihj.15-218

(DOI: 10.1536/ihj.15-218, PubMed: 26549390) Mika Bando, Hirotsugu Yamada, Kenya Kusunose, Shuji Hayashi, Yuriko Takagawa, Yoshihito Saijo, Susumu Nishio, Kozue Ogasawara and Masataka Sata :
Pulmonary embolism due to right atrial free-floating thrombus during echocardiographic examination: a case of a pulmonary saddle thrombus.,
Journal of Echocardiography, Vol.13, No.4, 145-147, 2015.

(要約): A 69-year-old female with polymyositis was referred to our hospital with a chief complaint of dyspnea. Transthoracic echocardiography showed right ventricular overloading. In addition to two-dimensional echocardiography, observation of the abnormal free-floating string-like mass by three-dimensional echocardiography provided superior visualization of the features of the mass which protruded into the right ventricle across the tricuspid valve during diastole. These findings enabled us to confirm the diagnosis of venous thrombus. The thrombus disappeared during the echocardiographic examination. Multidetector-row computed tomography showed a string-like thrombus across the bifurcation of the main pulmonary artery. Anticoagulation therapy was initiated with heparin and warfarin, and fondaparinux was started on the fourth day. Three-dimensional echocardiography was useful in characterizing the motion and extent of the thrombus.
(キーワード): Anticoagulation / Echocardiography / Pulmonary embolism / Right atrial thrombus
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s12574-015-0263-3
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26408320; ● Summary page in Scopus @ Elsevier: 2-s2.0-84949101634

(DOI: 10.1007/s12574-015-0263-3, PubMed: 26408320, Elsevier: Scopus) Naoko Sawada, Hirotsugu Yamada, Kenya Kusunose, Shuji Hayashi, Takashi Iwase and Masataka Sata :
3D transthoracic echocardiography provides accurate cross-sectional area of the RV outflow tract.,
JACC. Cardiovascular Imaging, Vol.8, No.11, 1343-1345, 2015.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jcmg.2014.12.018
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25797126; ● Summary page in Scopus @ Elsevier: 2-s2.0-84947031165

(DOI: 10.1016/j.jcmg.2014.12.018, PubMed: 25797126, Elsevier: Scopus) Shusuke Yagi, Ken-ichi Aihara, Daiju Fukuda, Akira Takashima, Mika Bando, Tomoya Hara, Sachiko Nishimoto, Takayuki Ise, Kenya Kusunose, Koji Yamaguchi, Takeshi Tobiume, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Michio Shimabukuro, Masashi Akaike and Masataka Sata :
Reduced ratio of eicosapentaenoic acid and docosahexaenoic acid to arachidonic acid is associated with early onset of acute coronary syndrome.,
Nutrition Journal, Vol.14, No.1, 111, 2015.

(要約): BACKGROUND: The hospitalization rate for acute coronary syndrome (ACS) for people aged 50 has remained stable over the past decade. Increased serum levels of n-3 polyunsaturated fatty acids (PUFAs), such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are associated with a decreased incidence of cardiovascular events and mortality in older patients; however, it is currently unknown whether reduced serum levels of n-3 PUFAs is also a risk factor for ACS in patients aged 50 years.METHODS AND RESULTS: We retrospectively reviewed 102 (male/ female 73/29) Japanese ACS patients whose serum levels of EPA/arachidonic acid (AA) and DHA/AA were evaluated on admission. The EPA/AA ratio was the lowest in patients aged 50 compared to patients aged 51-74 and 75. Pearson correlation analysis showed that early ACS onset was associated with low EPA/AA and DHA/AA ratios, and multiple regression analysis determined that decreased ratios of EPA/AA and DHA/AA, and male sex, current smoker status, increased body mass index and triglyceride levels, independently correlated with early ACS onset. Conversely, low-density and high-density lipoproteins, glycated hemoglobin, and hypertension did not correlate with early ACS onset. Subgroup analyses of male patients revealed that decreased ratios of EPA/AA and DHA/AA independently correlated with early ACS onset.CONCLUSION: Decreased EPA/AA and DHA/AA ratios may be risk factors for early onset of ACS, suggesting that reduced EPA/AA and DHA/AA may represent targets for preventing ACS in Japanese young people.
(出版サイトへのリンク): ● Publication site (DOI): 10.1186/s12937-015-0102-4
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26514181; ● Summary page in Scopus @ Elsevier: 2-s2.0-84945959581

(DOI: 10.1186/s12937-015-0102-4, PubMed: 26514181, Elsevier: Scopus) S Bando, Daiju Fukuda, Takeshi Soeki, S Nishimoto, E Uematsu, Tomomi Matsuura, Takayuki Ise, Takeshi Tobiume, Koji Yamaguchi, Shusuke Yagi, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Expression of NLRP3 in subcutaneous adipose tissue is associated with coronary atherosclerosis.,
Atherosclerosis, Vol.242, No.2, 407-414, 2015.

(要約): ObjectivesThe promotion of adipose tissue inflammation by lifestyle-related diseases such as obesity and diabetes accelerates atherogenesis; however, the underlying mechanisms remain incompletely understood. Nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3 (NLRP3) inflammasome contributes to chronic inflammation in adipose tissue. Here, we investigated the link between NLRP3 expression in subcutaneous adipose tissue (SAT) and the severity of coronary atherosclerosis.Methods and resultsSAT was obtained from 72 patients who underwent heart device implantation and coronary angiography. Expression of NLRP3 inflammasome-related molecules (NLRP3, IL-1 and IL-18) in SAT were evaluated by quantitative RT-PCR. Laboratory markers related to lifestyle-related diseases were measured. Patients with obesity, dyslipidemia (P < 0.05, respectively), diabetes or hyperuricemia (P < 0.01, respectively) had significantly higher expression of NLRP3. Multivariate analysis demonstrated that body mass index and serum level of uric acid were predictors of NLRP3 expression in SAT. The expression of NLRP3 in SAT correlated negatively with serum adiponectin level (r = 0.23, P < 0.05). Patients with coronary artery disease showed higher NLRP3 expression than patients without significant stenosis (P < 0.01). Furthermore, the expression of NLRP3 in SAT correlated positively with the severity of coronary atherosclerosis as determined by Gensini score (r = 0.47, P < 0.0001) or SYNTAX score (r = 0.55, P < 0.0001). Multiple regression analysis revealed that the expression of NLRP3 in SAT remains as an independent predictors for the severity of coronary atherosclerosis.ConclusionsThe expression of NLRP3 in SAT, which is affected by lifestyle-related diseases, is associated with the severity of coronary atherosclerosis. Our results suggest that NLRP3 inflammasome in SAT may have a role in atherogenesis.
(キーワード): Atherosclerosis / Adipose tissue / Inflammation / NLRP3 inflammasome / Lifestyle-related disease
(徳島大学機関リポジトリ): ● Metadata: 109532
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.atherosclerosis.2015.07.043
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26282945; ● Search Scopus @ Elsevier (PMID): 26282945; ● Search Scopus @ Elsevier (DOI): 10.1016/j.atherosclerosis.2015.07.043

(徳島大学機関リポジトリ: 109532, DOI: 10.1016/j.atherosclerosis.2015.07.043, PubMed: 26282945) Hara Tomoya, Daiju Fukuda, Tanaka Kimie, Higashikuni Yasutomi, Hirata Yoichiro, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Rivaroxaban, a novel oral anticoagulant, attenuates atherosclerotic plaque progression and destabilization in ApoE-deficient mice.,
Atherosclerosis, Vol.242, No.2, 639-646, 2015.

(要約): OBJECTIVE: Activated factor X (FXa) plays a key role in the coagulation cascade, whereas accumulating evidence suggests that it also contributes to the pathophysiology of chronic inflammation on the vasculature. In this study, we assessed the hypothesis that rivaroxaban (Riv), a direct FXa inhibitor, inhibits atherogenesis by reducing macrophage activation.METHODS AND RESULTS: Expression levels of PAR-1 and PAR-2, receptors for FXa, increased in the aorta of apolipoprotein E-deficient (ApoE(-/-)) mice compared with wild-type mice (P < 0.01, P < 0.05, respectively). Administration of Riv (5 mg/kg/day) for 20 weeks to 8-week-old ApoE(-/-) mice reduced atherosclerotic lesion progression in the aortic arch as determined by en-face Sudan IV staining compared with the non-treated group (P < 0.05) without alteration of plasma lipid levels and blood pressure. Histological analyses demonstrated that Riv significantly decreased lipid deposition, collagen loss, macrophage accumulation and matrix metallopeptidase-9 (MMP-9) expression in atherosclerotic plaques in the aortic root. Quantitative RT-PCR analyses using abdominal aorta revealed that Riv significantly reduced mRNA expression of inflammatory molecules, such as MMP-9, tumor necrosis factor- (TNF-). In vitro experiments using mouse peritoneal macrophages or murine macrophage cell line RAW264.7 demonstrated that FXa increased mRNA expression of inflammatory molecules (e.g., interleukin (IL)-1 and TNF-), which was blocked in the presence of Riv.CONCLUSIONS: Riv attenuates atherosclerotic plaque progression and destabilization in ApoE(-/-) mice, at least in part by inhibiting pro-inflammatory activation of macrophages. These results indicate that Riv may be particularly beneficial for the management of atherosclerotic diseases, in addition to its antithrombotic activity.
(キーワード): Activated factor X / 動脈硬化 (atherosclerosis) / Coagulation / 炎症 (inflammation) / Macrophages / Rivaroxaban
(徳島大学機関リポジトリ): ● Metadata: 109485
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.atherosclerosis.2015.03.023
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25817329; ● Summary page in Scopus @ Elsevier: 2-s2.0-84941742835

(徳島大学機関リポジトリ: 109485, DOI: 10.1016/j.atherosclerosis.2015.03.023, PubMed: 25817329, Elsevier: Scopus) Susumu Nishio, Kenya Kusunose, Hirotsugu Yamada, Masami Yamao, Yukina Hirata, Kazuhiro Mori, Suguru Matsuoka and Masataka Sata :
Echocardiographic screening for congenital heart disease in 8819 children: A report from local community events for children's healthcare.,
Journal of Cardiology, Vol.66, No.4, 315-319, 2015.

(要約): BACKGROUND: We had the opportunity to perform echocardiographic screening of children at local community events for children's healthcare sponsored by the prefectural government. The aim of this study was to assess the utility of echocardiographic screening by measuring the prevalence of congenital heart disease (CHD) and abnormal findings in children without history of diagnosed CHD.METHODS: Subjects consisted of 8819 infants and preschool children (1 month to 6 years) who underwent echocardiographic examination at public events from 2001 to 2013. Children with known CHD were excluded.RESULTS: We performed echocardiographic screening on 752 (range: 464-993) children at each event. At a total of 12 events, subjects consisted of 3175 infants less than one year (36%), 2292 one-year-olds (26%), 1058 two-year-olds (12%), 794 three-year-olds (9%), and other children up to age six years. We identified echocardiographic abnormalities in 137 children (15.5/1000 subjects), and 89 children (10.1/1000 subjects) were diagnosed with CHD. The prevalence of an echocardiographic abnormality did not change over the 12-year period (Kendall's tau=-0.272, p=0.19).CONCLUSIONS: CHD which could not be identified by prenatal echocardiography and neonatal auscultation could be detected in a substantial number of young children by echocardiographic screening. Echocardiographic screening may be useful for early diagnosis of CHD. However, our study is based on cross-sectional data without follow-up. Larger prospective studies are needed to verify the utility of echocardiographic screening with follow-up data in this cohort.
(キーワード): Congenital heart disease / Echocardiography / Screening
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jjcc.2014.11.011
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25572021; ● Summary page in Scopus @ Elsevier: 2-s2.0-84939572949

(DOI: 10.1016/j.jjcc.2014.11.011, PubMed: 25572021, Elsevier: Scopus) Michio Shimabukuro, Yoshimasa Hasegawa, Moritake Higa, Rie Amano, Hirotsugu Yamada, Shunsaku Mizushima, Hiroaki Masuzaki and Masataka Sata :
Subclinical carotid atherosclerosis burden in Japanese: comparison between Okinawa and Nagano residents.,
Journal of Atherosclerosis and Thrombosis, Vol.22, No.8, 854-868, 2015.

(要約): AIM: The prevalence of overweight and a change in atherosclerotic lipid profiles may be linked to region-specific differences in atherosclerotic diseases. We evaluated whether the lipid phenotype could be linked to region- and sex-specific differences in the degree of atherosclerosis.METHODS: Non-diabetic subjects included Okinawa (n=1674) and Nagano (n=1392) residents aged 30-75 years who underwent carotid ultrasonography for the measurement of maximum intima-media thickness (max IMT).RESULTS: Average max IMT was higher in Okinawa men and women, and the increase in max IMT with age was enhanced in men. Multiple regression analysis showed that in addition to age and systolic blood pressure, low-density lipoprotein cholesterol and non-high-density lipoprotein cholesterol were IMT determinants only in men for both Okinawa and Nagano. Meanwhile, HDL-cholesterol was a determinant for Okinawa men and women, but not for Nagano men and women.CONCLUSIONS: This is the first report to show region- and sex-specific differences in the determinants for max IMT in a Japanese population. The evaluation of the relationship between lipid profile patterns and region- and sex-specific differences in carotid atherosclerosis burden may be required.
(出版サイトへのリンク): ● Publication site (DOI): 10.5551/jat.26674
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26133316; ● Summary page in Scopus @ Elsevier: 2-s2.0-84940380486

(DOI: 10.5551/jat.26674, PubMed: 26133316, Elsevier: Scopus) Yukina Hirata, Hirotsugu Yamada, Kenya Kusunose, Takashi Iwase, Susumu Nishio, Shuji Hayashi, Mika Bando, Rie Amano, Koji Yamaguchi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Clinical Utility of Measuring Epicardial Adipose Tissue Thickness with Echocardiography Using a High-Frequency Linear Probe in Patients with Coronary Artery Disease.,
Journal of the American Society of Echocardiography, Vol.28, No.10, 1240-1246.e1, 2015.

(要約): The relationship between epicardial adipose tissue (EAT) and coronary artery disease (CAD) has recently attracted a great deal of attention in the medical community. The objective of this study was to determine whether measuring EAT thickness in the anterior interventricular groove (AIG) using echocardiography is feasible and whether this index can be a marker of CAD. A total of 311 patients (mean age, 67 ± 11 years; 208 men) who underwent coronary angiography between December 2011 and December 2013 were prospectively enrolled. EAT-AIG thickness and EAT thickness on the free wall of the right ventricle (RV) were measured in systole using a high-frequency linear probe. Seventy-one patients who underwent multidetector-row computed tomography were enrolled to validate the method for measuring EAT thickness using echocardiography. Subjects were divided into two groups, those with and without significant coronary stenosis, on the basis of findings on coronary angiography (≥ 75% luminal narrowing). EAT-AIG thickness measured using echocardiography was validated by computed tomography. EAT-AIG thickness was strongly correlated with EAT volume (r = 0.714, P < .001). The CAD group had thicker EAT-AIG than the non-CAD group (8.3 ± 3.0 vs 6.3 ± 2.5 mm, P < .001). EAT-RV thickness was greater in the CAD group than in the non-CAD group (5.0 ± 2.1 vs 4.4 ± 2.3 mm, P = .009) as well. The area under the curve on receiver operating characteristic curve analysis of EAT-AIG thickness for predicting CAD was 0.704, which was higher than the EAT-RV thickness. Measuring EAT thickness using echocardiography with a high-frequency linear probe was validated with computed tomography. EAT-AIG was thicker in the CAD group than in the non-CAD group, as was EAT-RV thickness. This noninvasive index may have potential as a diagnostic marker for predicting coronary atherosclerosis.
(徳島大学機関リポジトリ): ● Metadata: 109714
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.echo.2015.07.006
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26275751; ● Summary page in Scopus @ Elsevier: 2-s2.0-84944180106

(徳島大学機関リポジトリ: 109714, DOI: 10.1016/j.echo.2015.07.006, PubMed: 26275751, Elsevier: Scopus) Shusuke Yagi, Ken-ichi Aihara, Masashi Akaike, Daiju Fukuda, HM Salim, Masayoshi Ishida, Tomomi Matsuura, Takayuki Ise, Koji Yamaguchi, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Michio Shimabukuro, Toshio Matsumoto and Masataka Sata :
Predictive factors for efficacy of dipeptidyl peptidase-4 inhibitors in patients with type 2 diabetes mellitus.,
Diabetes & Metabolism Journal, Vol.39, No.4, 342-347, 2015.

(要約): BACKGROUND: Predictive factors for the efficacy of dipeptidyl peptidase-4 (DPP-4) inhibitors for lowering glycosylated hemoglobin (HbA1c) remain unclear in patients with type 2 diabetes mellitus. The aim of this study is therefore to clarify predictive factors of the efficacy of DPP-4 inhibitors for lowering HbA1c after 12 months of treatment.METHODS: A total of 191 consecutive type 2 diabetic patients (male sex 55%, mean age, 68.3±35.8 years), who had been treated with DPP-4 inhibitors for 12 months, were enrolled in this study and evaluated retrospectively.RESULTS: After 12 months of DPP-4 inhibitor treatment, random blood glucose level, and HbA1c level, decreased from 167±63 to 151±49 mg/dL (P<0.01), and from 7.5%±1.3% to 6.9%±0.9% (P<0.01) respectively, without severe side effects. Multiple regression analysis showed that predictors of DPP-4 inhibitor treatment efficacy in lowering HbA1c level after 12 months were a decrease in HbA1c level after 3 months of treatment, a high baseline HbA1c level, a low baseline body mass index, and the absence of coronary artery disease.CONCLUSION: Most suitable candidates for treatment with DPP-4 inhibitors are diabetics who are not obese and do not have coronary artery disease. In addition, long-term efficacy of DPP-4 inhibitors can be predicted by decrement of HbA1c after 3 months of treatment.
(キーワード): Coronary artery disease / 糖尿病 (diabetes mellitus) / Dipeptidyl-peptidase IV inhibitors / Obese / Predictive factors
(出版サイトへのリンク): ● Publication site (DOI): 10.4093/dmj.2015.39.4.342
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26301197; ● Summary page in Scopus @ Elsevier: 2-s2.0-84939780057

(DOI: 10.4093/dmj.2015.39.4.342, PubMed: 26301197, Elsevier: Scopus) Kenya Kusunose, Hirotsugu Yamada, Junko Hotsuchi, Mika Bando, Susumu Nishio, Yukina Hirata, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki, Jun Kishi and Masataka Sata :
Prediction of Future Overt Pulmonary Hypertension by 6-Min Walk Stress Echocardiography in Patients With Connective Tissue Disease.,
Journal of the American College of Cardiology, Vol.66, No.4, 376-384, 2015.

(要約): BACKGROUND: Early detection of pulmonary hypertension (PH) in connective tissue disease (CTD) is crucial to ensuring that patients receive timely treatment for this progressive disease. Exercise stress tests have been used to screen patients in an attempt to identify early-stage PH. Recent studies have described abnormal mean pulmonary artery pressure (mPAP)-cardiac output (Q) responses as having the potential to assess the disease state.OBJECTIVES: This study hypothesized that pulmonary circulation pressure-flow relationships obtained by 6-min walk (6MW) stress echocardiography would better delineate differential progression of PH and predict development of PH during follow-up.METHODS: We prospectively performed 6MW stress echocardiographic studies in 78 CTD patients (age 58 ± 12 years; 9% male) at baseline and follow-up. All patients underwent yearly echocardiographic follow-up studies for up to 5 years.RESULTS: During a median period of 32 months (range: 15 to 62 months), 16 patients reached the clinical endpoint of development of PH and none died during follow-up. PH was confirmed by right heart catheterization in all 16 patients (mPAP 25 mm Hg and pulmonary capillary wedge pressure 15 mm Hg). In a Cox proportional-hazards survival model, 6MW distance (hazard ratio [HR]: 0.99; p = 0.010), early diastolic tricuspid annulus motion velocity (HR: 0.79; p = 0.025), and mPAP/Q by 6MW stress (HR: 1.10; p = 0.005) were associated with development of PH. In sequential Cox models, a model on the basis of 6MW distance (chi-square, 6.6) was improved by mPAP/Q (chi-square: 14.4; p = 0.019). Using a receiver-operating characteristic curve, we found that the best cutoff value of mPAP/Q for predicting development of pulmonary hypertension was >3.3 mm Hg/l/min.CONCLUSIONS: The 6MW stress echocardiography noninvasively provides an incremental prognostic value of PH development in CTD. This is a single-center prospective cohort study. Larger multicenter studies are warranted to confirm this result.
(キーワード): lupus erythematosus / mixed connective tissue disease / pulmonary circulation / systemic scleroderma
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jacc.2015.05.032
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26205595; ● Summary page in Scopus @ Elsevier: 2-s2.0-84937681606

(DOI: 10.1016/j.jacc.2015.05.032, PubMed: 26205595, Elsevier: Scopus) Mika Bando, Hirotsugu Yamada, Kenya Kusunose, Daiju Fukuda, Rie Amano, Rina Tamai, Yuta Torii, Yukina Hirata, Susumu Nishio, Koji Yamaguchi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Comparison of carotid plaque tissue characteristics in patients with acute coronary syndrome or stable angina pectoris: assessment by iPlaque, transcutaneous carotid ultrasonography with integrated backscatter analysis.,
Cardiovascular Ultrasound, Vol.13, No.1, 34, 2015.

(要約): BACKGROUND: The association of the tissue characteristics of carotid plaques with coronary artery disease has attracted interest. The present study compared the tissue characteristics of carotid plaques in patients with acute coronary syndrome (ACS) with those in patients with stable angina pectoris (SAP) using the iPlaque system, which is based on ultrasound integrated backscatter.METHODS AND RESULTS: Carotid ultrasound examinations were performed in 26 patients with ACS, and 38 age- and gender-matched patients with SAP. Neither plaque area nor maximal intima-media thickness differed significantly between the two groups. However, the average integrated backscatter value within the plaque was greater in the ACS patients than in the SAP patients. iPlaque analysis revealed that the percentage blue area (lipid pool) was greater in the ACS patients than in the SAP patients (43.4±11.2 vs 18.3±10.3 %, p<0.0001), and that the percentage green area (fibrosis) was lower in the ACS than in the SAP patients (7.5±7.5 % vs 20.7±11.7 %, p<0.0001).CONCLUSIONS: The lipid component of carotid plaques is greater in ACS patients than in SAP patients. Our iPlaque system provides a useful and feasible method for the tissue characterization of carotid plaques in the clinical setting.
(キーワード): Carotid arteries / Plaque vulnerability / 超音波 (ultrasound) / Acute coronary syndrome (ACS)
(徳島大学機関リポジトリ): ● Metadata: 109520
(出版サイトへのリンク): ● Publication site (DOI): 10.1186/s12947-015-0031-6
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26209244; ● Summary page in Scopus @ Elsevier: 2-s2.0-84937791819

(徳島大学機関リポジトリ: 109520, DOI: 10.1186/s12947-015-0031-6, PubMed: 26209244, Elsevier: Scopus) Hiromu Yamazaki, Koji Yamaguchi, Takeshi Soeki, Tetsuzo Wakatsuki, Toshiyuki Niki, Yoshio Taketani, Atsunori Kitaoka, Kenya Kusunose, Takayuki Ise, Takeshi Tobiume, Shusuke Yagi, Takashi Iwase, Hirotsugu Yamada and Masataka Sata :
Impact of indoxyl sulfate, a uremic toxin, on non-culprit coronary plaque composition assessed by integrated backscatter intravascular ultrasound.,
Circulation Journal, Vol.79, No.8, 1773-1779, 2015.

(要約): BACKGROUND: Uremic toxin has emerged as an important determinant of cardiovascular risk. The aim of this study was to examine the relationship between serum uremic toxin and coronary plaque composition on integrated backscatter intravascular ultrasound (IB-IVUS).MethodsandResults:IB-IVUS was performed in 47 patients with planned treatment for angina pectoris. Non-culprit intermediate plaque analyzed in this study had to be >5 mm apart from the intervention site. 3-D IB-IVUS analysis was performed to determine percent lipid volume (LV) and fibrous volume (FV). We also measured serum uremic toxins (indoxyl sulfate [IS], asymmetric dimethylarginine [ADMA], and p-cresol [PC]). Glomerular filtration rate correlated with IS (r=-0.329, P=0.04), but did not correlate with ADMA or PC. Percent LV correlated with IS (r=0.365, P=0.02), but did not correlate with ADMA or PC. Percent FV also correlated with IS (r=-0.356, P=0.03), but did not correlate with ADMA or PC. On multivariate regression, only IS was associated with percent LV (r=0.359, P=0.04) and percent FV (r=-0.305, P=0.04) independently of potentially confounding coronary risk factors.CONCLUSIONS: Among the uremic toxins, serum IS might be a novel useful biomarker to detect and monitor lipid-rich coronary plaque on IB imaging. (Circ J 2015; 79: 1773-1779).
(キーワード): Coronary plaque / Indoxyl sulfate / Integrated backscatter intravascular ultrasound
(徳島大学機関リポジトリ): ● Metadata: 109533
(出版サイトへのリンク): ● Publication site (DOI): 10.1253/circj.CJ-15-0019
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25971408; ● Summary page in Scopus @ Elsevier: 2-s2.0-84937904061

(徳島大学機関リポジトリ: 109533, DOI: 10.1253/circj.CJ-15-0019, PubMed: 25971408, Elsevier: Scopus) S Hayashi, Hirotsugu Yamada, Mika Bando, Y Saijo, S Nishio, Y Hirata, AL Klein and Masataka Sata :
Optimal analysis of left atrial strain by speckle tracking echocardiography: P-wave versus R-wave trigger.,
Echocardiography, Vol.32, No.8, 1241-1249, 2015.

(要約): BACKGROUND: Left atrial (LA) strain analysis using speckle tracking echocardiography is useful for assessing LA function. However, there is no established procedure for this method. Most investigators have determined the electrocardiographic R-wave peak as the starting point for LA strain analysis. To test our hypothesis that P-wave onset should be used as the starting point, we measured LA strain using 2 different starting points and compared the strain values with the corresponding LA volume indices obtained by three-dimensional (3D) echocardiography.METHODS: We enrolled 78 subjects (61 ± 17 years, 25 males) with and without various cardiac diseases in this study and assessed global longitudinal LA strain by two-dimensional speckle tracking strain echocardiography using EchoPac software. We used either R-wave peak or P-wave onset as the starting point for determining LA strains during the reservoir (Rres, Pres), conduit (Rcon, Pcon), and booster pump (Rpump, Ppump) phases. We determined the maximum, minimum, and preatrial contraction LA volumes, and calculated the LA total, passive, and active emptying fractions using 3D echocardiography.RESULTS: The correlation between Pres and LA total emptying fraction was better than the correlation between Rres and LA total emptying fraction (r = 0.458 vs. 0.308, P = 0.026). Pcon and Ppump exhibited better correlation with the corresponding 3D echocardiographic parameters than Rcon (r = 0.560 vs. 0.479, P = 0.133) and Rpump (r = 0.577 vs. 0.345, P = 0.003), respectively.CONCLUSIONS: LA strain in any phase should be analyzed using P-wave onset as the starting point rather than R-wave peak.
(キーワード): left atrium / strain / three-dimensional echocardiography / two-dimensional speckle tracking
(出版サイトへのリンク): ● Publication site (DOI): 10.1111/echo.12834
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25363348; ● Summary page in Scopus @ Elsevier: 2-s2.0-84937512721

(DOI: 10.1111/echo.12834, PubMed: 25363348, Elsevier: Scopus) Hirotsugu Yamada and Masataka Sata :
Does echocardiographic epicardial adipose tissue thickness become a useful biomarker?,
Journal of Atherosclerosis and Thrombosis, Vol.22, No.6, 555-556, 2015.

(出版サイトへのリンク): ● Publication site (DOI): 10.5551/jat.ED015
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25891211; ● Summary page in Scopus @ Elsevier: 2-s2.0-84931043161

(DOI: 10.5551/jat.ED015, PubMed: 25891211, Elsevier: Scopus) Kenya Kusunose, Junko Hotsuchi, Y Takagawa, S Nishio, Takayuki Ise, Takeshi Tobiume, Koji Yamaguchi, Shusuke Yagi, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Serial imaging changes during treatment of immunoglobulin G4-related disease with multiple pseudotumors.,
Circulation, Vol.131, No.21, 1882-1883, 2015.

(キーワード): Aged, 80 and over / Antibodies, Anti-Idiotypic / Arteries / Cardiomegaly / Coronary Aneurysm / Eyelid Diseases / Fluorodeoxyglucose F18 / Humans / Immunoglobulin G / Male / Paraproteinemias / Plasma Cells / Positron-Emission Tomography / Radiopharmaceuticals / Tomography, X-Ray Computed
(出版サイトへのリンク): ● Publication site (DOI): 10.1161/CIRCULATIONAHA.115.015638
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26015466; ● Summary page in Scopus @ Elsevier: 2-s2.0-84936080389

(DOI: 10.1161/CIRCULATIONAHA.115.015638, PubMed: 26015466, Elsevier: Scopus) Shusuke Yagi, Ken-ichi Aihara, Daiju Fukuda, Akira Takashima, Tomoya Hara, Junko Hotsuchi, Takayuki Ise, Koji Yamaguchi, Takeshi Tobiume, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Michio Shimabukuro, Masashi Akaike and Masataka Sata :
Effects of docosahexaenoic acid on the endothelial function in patients with coronary artery disease.,
Journal of Atherosclerosis and Thrombosis, Vol.22, No.5, 447-454, 2015.

(要約): AIM: The consumption of n-3 polyunsaturated fatty acids (PUFA), including docosahexaenoic acid DHA), reduces the incidence of cardiovascular events, and reduced serum levels of n-3 PUFA may be associated with an increased risk of cardiovascular events. However, controversy remains regarding which components of PUFA are associated with the endothelial function in patients with coronary artery disease (CAD). We therefore examined the associations between the n-3 and n-6 PUFA levels and CAD.METHODS: We retrospectively reviewed 160 consecutive Japanese patients with CAD whose endothelial function was measured according to the percent change in flow-mediated dilation (FMD) and the serum levels of n-3 PUFA, including eicosapentaenoic acid (EPA) and DHA, and n-6 PUFA, including arachidonic acid (AA) and dihomo-gamma-linolenic acid (DHLA).RESULTS: A single regression analysis showed no relationships between the FMD and the serum levels of PUFA, including EPA, DHA, AA and DHLA. In contrast, a multiple regression analysis showed that the DHA level was a positive (P0.01) and age was a negative (P0.001) contributor to an increased FMD; however, sex, body mass index, systolic and diastolic blood pressure, current/past smoking and the levels of HbA1c, triglycerides, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, EPA, AA and DHLA did not significantly affect the outcome.CONCLUSIONS: The serum level of DHA is associated with the endothelial function evaluated according to the FMD in patients with CAD, thus suggesting that a low serum level of DHA may be a predictive biomarker for endothelial dysfunction.
(キーワード): Flow-mediated dilation / n-3 polyunsaturated fatty acids / Docosahexaenoic acid
(出版サイトへのリンク): ● Publication site (DOI): 10.5551/jat.26914
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25342567; ● CiNii @ 国立情報学研究所 (CRID): 1390001204431540352; ● Summary page in Scopus @ Elsevier: 2-s2.0-84929412906

(DOI: 10.5551/jat.26914, PubMed: 25342567, CiNii: 1390001204431540352, Elsevier: Scopus) Toshiyuki Niki, Takeshi Soeki, Koji Yamaguchi, Yoshio Taketani, Shusuke Yagi, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Elevated concentration of interferon-inducible protein of 10 kD (IP-10) is associated with coronary atherosclerosis.,
International Heart Journal, Vol.56, No.3, 269-272, 2015.

(要約): Several studies have shown that various chemokines are more highly expressed in atherosclerotic plaques than in normal vessel walls. In the present study, we investigated the relationship between coronary atherosclerosis and noteworthy chemokines, including interferon-inducible protein of 10 kD (IP-10); monocyte chemoattractant protein 1 (MCP-1); regulated on activation, normal T-cell expressed and secreted (RANTES); and high-sensitivity C-reactive protein (hsCRP), an established marker of atherosclerotic disease. We studied 28 patients who underwent coronary angiography because of suspected coronary artery disease (CAD). CAD was defined as stenosis of more than 50% of the vessel diameter on coronary angiograms. Blood samples were obtained both from the aorta and the coronary sinus (CS) just before coronary angiography. Relative to CAD (-) patients, those who were CAD (+) tended to have higher plasma concentrations of IP-10 in the aorta, as well as significantly higher transcoronary concentration gradients of circulating IP-10. There were no significant differences between the two groups in aortic plasma concentrations or transcoronary concentration gradients of MCP-1, RANTES, and hsCRP. Furthermore, both the aortic plasma concentrations and transcoronary concentration gradients of IP-10 correlated with the Gensini score (r = 0.58 and r = 0.63, respectively, P < 0.01), while the plasma MCP-1, RANTES, and serum hsCRP concentrations did not. This study suggests that IP-10 is a good surrogate marker of coronary atherosclerosis.
(キーワード): Coronary artery disease / Coronary circulation / Chemokine
(出版サイトへのリンク): ● Publication site (DOI): 10.1536/ihj.14-300
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25902883; ● Search Scopus @ Elsevier (PMID): 25902883; ● Search Scopus @ Elsevier (DOI): 10.1536/ihj.14-300

(DOI: 10.1536/ihj.14-300, PubMed: 25902883) S Hayashi, Hirotsugu Yamada, S Nishio, Junko Hotsuchi, Mika Bando, Y Takagawa, Y Saijo, Y Hirata and Masataka Sata :
Age-and gender-specific changes of tricuspid annular motion velocities in normal hearts.,
Journal of Cardiology, Vol.65, No.5, 397-402, 2015.

(要約): Mitral annular motion (MAM) and tricuspid annular motion (TAM) velocities obtained by pulsed tissue Doppler echocardiography have been used to evaluate left ventricular (LV) and right ventricular (RV) functions. Although TAM velocity has been clinically applied for evaluating various cardiac diseases, the effects of age and gender remain unclear. Therefore, we aimed to determine the effects of age and gender on TAM velocity in normal hearts. We randomly selected 265 subjects (mean age, 59 years; range, 20-89 years) without abnormal clinical, electrocardiographic, and echocardiographic findings from a pool of subjects who had undergone transthoracic echocardiography. They were classified into four age groups: 20-39, 40-59, 60-79, and >80 years. Pulsed wave Doppler was applied to obtain MAM velocity of the lateral side and TAM velocity of the RV free wall side. The peak systolic (s'), early diastolic (e'), and atrial systolic (a') velocities of MAM and TAM were measured in all subjects. While MAM-s' (r=-0.267, p<0.001) correlated with age, TAM-s' did not (p=0.755). TAM-s' in any age groups had no significant gender differences. TAM-e' (r=-0.447, p<0.001) and MAM-e' (r=-0.724, p<0.001) correlated with age, respectively. In those aged 40-59 years, both TAM-e' (p=0.002) and MAM-e' (p=0.048) in females were significantly higher than those in males. The gender differences diminished in the ≥60 years age groups. There was no age-associated decline in TAM-s', while TAM-e' varied with age and gender as did MAM-e'. Although the same criteria for the TAM-s' can be used for identifying abnormal RV systolic function regardless of age and gender, age and gender differences must be considered when one utilizes the TAM-e' for the diagnosis or management of cardiovascular disease.
(キーワード): Tricuspid annular motion / Tissue Doppler echocardiography / Aging / Gender / Mitral annular motion
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jjcc.2014.06.013
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25062786; ● Summary page in Scopus @ Elsevier: 2-s2.0-84928929859

(DOI: 10.1016/j.jjcc.2014.06.013, PubMed: 25062786, Elsevier: Scopus) S Nakatani, M Akaishi, T Asanuma, S Hashimoto, C Izumi, S Iwanaga, H Kawai, M Daimon, H Toide, A Hayashida and Hirotsugu Yamada :
Guidelines from the Japanese Society of Echocardiography: Guidance for the management and maintenance of echocardiography equipment.,
Journal of Echocardiography, No.13, 1-5, 2015.

(要約): Echocardiography plays a pivotal role as an imaging modality in modern cardiology practice. Information derived from echocardiography is definitely helpful for patient care. The Japanese Society of Echocardiography has promoted echocardiography in routine clinical and research use. One of the missions of the Society is to provide information that is useful for high-quality examinations. To ensure this, we believe that equipment in good condition and a comfortable environment are important for both patient and examiner. Here, the Guideline Preparation Committee of the Japanese Society of Echocardiography has established brief guidance for the routine use of echocardiography equipment.
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s12574-015-0240-x
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26184515; ● Summary page in Scopus @ Elsevier: 2-s2.0-84922570229

(DOI: 10.1007/s12574-015-0240-x, PubMed: 26184515, Elsevier: Scopus) Hirotsugu Yamada and Masataka Sata :
The role of pericardial fat: The good, the bad and the ugly.,
Journal of Cardiology, Vol.65, No.1, 2-4, 2015.

(キーワード): Pericardial adipose tissue / Epicardial adipose tissue / Coronary artery disease
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jjcc.2014.07.004
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25149094; ● Summary page in Scopus @ Elsevier: 2-s2.0-84930182808

(DOI: 10.1016/j.jjcc.2014.07.004, PubMed: 25149094, Elsevier: Scopus) Takeshi Soeki, Koji Yamaguchi, Toshiyuki Niki, E Uematsu, S Bando, T Matsuura, Takayuki Ise, Kenya Kusunose, Junko Hotsuchi, Takeshi Tobiume, Shusuke Yagi, Daiju Fukuda, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Plasma microRNA-100 is associated with coronary plaque vulnerability.,
Circulation Journal, Vol.79, No.2, 413-418, 2015.

(要約): BACKGROUND: Although numerous studies have reported altered plasma levels of various microRNAs (miRNAs) in patients with cardiovascular disease, there are no data on the relationship between plasma miRNAs and vulnerable coronary plaque. In this study, we investigated whether plasma miRNAs might be a sensitive marker of coronary plaque vulnerability.MethodsandResults:Integrated backscatter intravascular ultrasound (IB-IVUS) was performed in 32 consecutive patients with angina pectoris who underwent percutaneous coronary intervention. Three-dimensional analysis of IB-IVUS was performed to determine the percentage of lipid volume (%LV) and fibrous volume (%FV). Circulating miRNAs were measured in EDTA-plasma simultaneously obtained from the aorta and the coronary sinus (CS). Muscle-enriched (miR-133a, miR-208a, miR-499), vascular-enriched (miR-92a, miR-100, miR-126, miR-127, miR-145), and myeloid cell-enriched miRNAs (miR-155, miR-223) were measured. Plasma miR-100 was higher in the CS than in the aorta, but there were no significant differences in the levels of other miRNAs between the aorta and CS. Plasma miR-100 in the aorta was positively correlated with %LV (r=0.48, P<0.01) and negatively correlated with %FV (r=-0.41, P<0.05). Importantly, transcoronary concentration gradient of circulating miR-100 was more strongly correlated with %LV (r=0.53, P<0.01) and %FV (r=-0.56, P<0.01).CONCLUSIONS: miR-100 might be released into the coronary circulation from vulnerable coronary plaques. This study provides insights into the role of miRNAs in coronary atherosclerotic disease. (Circ J 2015; 79: 413-418).
(キーワード): Coronary artery disease / Coronary circulation / Intravascular ultrasound / MicroRNA
(出版サイトへのリンク): ● Publication site (DOI): 10.1253/circj.CJ-14-0958
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25519160; ● CiNii @ 国立情報学研究所 (CRID): 1390001205108464000; ● Summary page in Scopus @ Elsevier: 2-s2.0-84928251309

(DOI: 10.1253/circj.CJ-14-0958, PubMed: 25519160, CiNii: 1390001205108464000, Elsevier: Scopus) S Kimura, Yuka Ueda, Takayuki Ise, Shusuke Yagi, Takashi Iwase, K Nishikawa, Koji Yamaguchi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Shinsuke Katoh, Masashi Akaike, Natsuo Yasui and Masataka Sata :
Impact of supervised cardiac rehabilitation on urinary albumin excretion in patients with cardiovascular disease.,
International Heart Journal, Vol.56, No.1, 105-109, 2015.

(要約): Urinary albumin excretion is a predictor of cardiovascular death. Cardiac rehabilitation (CR) with exercise training (ET) has been shown to improve exercise capacity and prognosis in patients with cardiovascular disease (CVD). However, it remains unclear whether CR reduces urinary albumin excretion in CVD patients. We performed a retrospective, observational study using data obtained from 98 male CVD patients without macroalbuminuria and estimated glomerular filtration rate (eGFR) < 30 mL/minute/1.73 m(2) who participated in CR with ET during hospitalization. Twenty-three patients continued supervised ET for 6 months (supervised group) and 75 patients quit supervised ET (non-supervised group). The supervised ET program consisted of 60 minutes of supervised sessions 1-3 times a week and 30-60 minutes of home exercise at least twice a week. Urinary albumin/creatinine ratio (ACR) was significantly decreased in the supervised group at 6 months after enrollment (43 ± 71 mg/g to 17 ± 20 mg/g creatinine, P < 0.05) but not in the non-supervised group. eGFR was unchanged in the supervised group but was significantly decreased in the non-supervised group (72 ± 18 mL/minute/1.73 m(2) to 67 ± 17 mL/minute/1.73 m(2), P < 0.001). The results of multiple regression analysis showed that only supervised ET was an independent contributor to ACR. CR with supervised ET decreased urinary albumin excretion without deterioration of renal function. These findings suggest that continuation of a supervised ET program is associated with reduction in the development of CVD and reduction in cardiovascular morbidity and mortality in CVD patients.
(キーワード): Cardiac rehabilitation / Renal function / Cardiovascular disease
(徳島大学機関リポジトリ): ● Metadata: 109367
(出版サイトへのリンク): ● Publication site (DOI): 10.1536/ihj.14-161
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25742947; ● Search Scopus @ Elsevier (PMID): 25742947; ● Search Scopus @ Elsevier (DOI): 10.1536/ihj.14-161

(徳島大学機関リポジトリ: 109367, DOI: 10.1536/ihj.14-161, PubMed: 25742947) Shusuke Yagi, A Takashima, M Mitsugi, T Wada, Junko Hotsuchi, Ken-ichi Aihara, T Hara, Masayoshi Ishida, Daiju Fukuda, Takayuki Ise, Koji Yamaguchi, Takeshi Tobiume, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Michio Shimabukuro, Masashi Akaike and Masataka Sata :
Effect of combination tablets containing amlodipine 10 mg and irbesartan 100 mg on blood pressure and cardiovascular risk factors in patients with hypertension.,
Therapeutics and Clinical Risk Management, Vol.11, 83-88, 2015.

(要約): Background: Hypertension is one of the major risk factors for cardiovascular and cerebrovascular disease and mortality. Patients who receive insufficient doses of antihypertensive agents or who are poorly adherent to multidrug treatment regimens often fail to achieve adequate blood pressure (BP) control. The aim of this study was to determine the efficacy of an angiotensin II receptor blocker (ARB) and calcium channel blocker (CCB) combination tablet containing a regular dose of irbesartan (100 mg) and a high dose of amlodipine (10 mg) with regard to lowering BP and other risk factors for cardiovascular disease.Methods: We retrospectively evaluated data from 68 patients with essential hypertension whose treatment regimen was changed either from combination treatment with an independent ARB and a low-dose or regular-dose CCB or from a combination tablet of ARB and a low-dose or regular-dose CCB to a combination tablet containing amlodipine 10 mg and irbesartan 100 mg, because of incomplete BP control. Previous treatments did not include irbesartan as the ARB.Results: The combination tablet decreased systolic and diastolic BP. In addition, it significantly decreased serum uric acid, low-density lipoprotein cholesterol, and increased high-density lipoprotein cholesterol levels, independent of the BP-lowering effect. Treatment with the combination tablet did not affect serum triglycerides, plasma glucose, glycated hemoglobin, serum potassium or creatinine levels, or the urinary albumin excretion rate.Conclusion: The combination tablet containing amlodipine 10 mg and irbesartan 100 mg had a greater BP-lowering effect than an ARB and a low-dose or regular-dose CCB. In addition, the combination tablet had more favorable effects on serum uric acid, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol levels in patients with hypertension.
(キーワード): blood pressure / combination tablet / uric acid / low-density lipoprotein cholesterol / high-density lipoprotein cholesterol
(出版サイトへのリンク): ● Publication site (DOI): 10.2147/TCRM.S72299
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25624765; ● Summary page in Scopus @ Elsevier: 2-s2.0-84921260560

(DOI: 10.2147/TCRM.S72299, PubMed: 25624765, Elsevier: Scopus) Shusuke Yagi, T Hara, R Ueno, Ken-ichi Aihara, Daiju Fukuda, A Takashima, Junko Hotsuchi, Takayuki Ise, Koji Yamaguchi, Takeshi Tobiume, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Michio Shimabukuro, Masashi Akaike and Masataka Sata :
Serum concentration of eicosapentaenoic acid is associated with cognitive function in patients with coronary artery disease.,
Nutrition Journal, Vol.13, No.1, 112, 2014.

(要約): BACKGROUND: Recent studies have shown that intake of n-3 polyunsaturated fatty acids (PUFAs) is associated with reduced risk of cognitive impairment and coronary artery disease (CAD); however, it is currently unknown whether reduced serum n-3 PUFA is associated with cognitive impairment in patients with CAD.METHODS: We retrospectively evaluated cognitive function with the mini-mental state examination (MMSE), serum levels of PUFAs (including eicosapentaenoic acid [EPA], docosahexaenoic acid [DHA], dihomogammalinolenic acid [DGLA], and arachidonic acid [AA]), cardiovascular risk factors (hypertension, dyslipidemia, diabetes mellitus, cerebrovascular disease, and history of current/previous smoking), and parameters of cardiac function (left ventricular ejection fraction and brain natriuretic peptide levels) in 146 Japanese CAD patients. The associations between the MMSE scores and the other parameters were evaluated.RESULTS: Pearson correlation analysis showed that EPA (R =0.25, P <0.01), EPA/AA ratio (R =0.22, P =0.01), and left ventricular ejection fraction (R =0.15, P =0.04) were positively associated with MMSE score, and that age (R = -0.20, P <0.01) and brain natriuretic peptide levels (R = -0.28, P <0.01) were inversely associated with MMSE score. Multiple regression analysis showed that age (P <0.05) was negatively associated with MMSE score, while EPA (P <0.01) and EPA/AA ratio (P <0.05) were positively associated with MMSE score; however, sex; body mass index; left ventricular ejection fraction; levels of DHA, AA, and DGLA; DHA/AA ratio; brain natriuretic peptide; and presence of hypertension, dyslipidemia, diabetes mellitus, cerebrovascular disease, and history of current/previous smoking were statistically excluded.CONCLUSIONS: Serum EPA concentration is associated with cognitive function in patients with CAD, suggesting that a low serum EPA level is a risk factor for cognitive impairment independent of cardiac function, including left ventricular ejection fraction. This correlation potentially lends further support to a role of dietary n-3 PUFAs in preventing the cognitive decline in CAD patients.
(キーワード): Aged / Arachidonic Acid / Cognition / Cognition Disorders / Coronary Disease / Eicosapentaenoic Acid / Fatty Acids, Omega-3 / Female / Humans / Japan / Male / Middle Aged / Retrospective Studies / Risk Factors / Stroke Volume
(出版サイトへのリンク): ● Publication site (DOI): 10.1186/1475-2891-13-112
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25471307; ● Summary page in Scopus @ Elsevier: 2-s2.0-84926465688

(DOI: 10.1186/1475-2891-13-112, PubMed: 25471307, Elsevier: Scopus) Takeshi Soeki, Kunihiko Koshiba, Toshiyuki Niki, Kenya Kusunose, Koji Yamaguchi, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro, Kazuo Minakuchi, I Kishimoto, Kenji Kangawa and Masataka Sata :
Effect of ghrelin on autonomic activity in healthy volunteers.,
Peptides, Vol.62, 1-5, 2014.

(要約): Ghrelin is a novel growth hormone (GH)-releasing peptide originally isolated from the stomach. Recently, we have shown that ghrelin suppresses cardiac sympathetic activity and prevents early left ventricular remodeling in rats with myocardial infarction. In the present study, we evaluated the effect of ghrelin on autonomic nerve activity in healthy human subjects. An intravenous bolus of human synthetic ghrelin (10g/kg) was administered to 10 healthy men (mean age, 33 years). Holter monitoring assessment was performed before and during 2h after the ghrelin therapy. The standard deviation of normal RR intervals (SDNN), square root of the mean of the sum of the squares of differences between adjacent RR intervals (rMSSD), high-frequency power (HF), and low-frequency power (LF) were analyzed. Blood samples were also obtained before and after the therapy. A single administration of ghrelin decreased both heart rate and blood pressure. Interestingly, ghrelin significantly decreased the LF and LF/HF ratio of heart rate variability and increased the SDNN, rMSSD, and HF. Ghrelin also elicited a marked increase in circulating GH, but not insulin-like growth factor-1. These data suggest that ghrelin might suppress cardiac sympathetic nerve activity and stimulate cardiac parasympathetic nerve activity.
(キーワード): Ghrelin / Autonomic nerve activity / Heart rate variability / Electrocardiography / Hemodynamics
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.peptides.2014.09.015
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25265271; ● Search Scopus @ Elsevier (PMID): 25265271; ● Search Scopus @ Elsevier (DOI): 10.1016/j.peptides.2014.09.015

(DOI: 10.1016/j.peptides.2014.09.015, PubMed: 25265271) Koji Yamaguchi, Tetsuzo Wakatsuki, Takeshi Soeki, Toshiyuki Niki, Yoshio Taketani, Hiroyasu Oeduka, Kenya Kusunose, Takayuki Ise, Takashi Iwase, Hirotsugu Yamada and Masataka Sata :
Effects of telmisartan on inflammatory cytokines and coronary plaque component as assessed on integrated backscatter intravascular ultrasound in hypertensive patients.,
Circulation Journal, Vol.78, No.1, 240-247, 2014.

(要約): Telmisartan has unique pleiotropic effects in addition to renin-angiotensin system (RAS)-inhibition effects. The aim of this study was to evaluate the effects of telmisartan on the coronary plaque component and local inflammatory cytokines. A total of 50 patients with hypertension were randomized to 2 groups: the telmisartan group (additional treatment with telmisartan 80mg/day, n=25) or the control group (additional treatment with other anti-hypertensive drugs except RAS blockers, n=25) for 6 months. Tissue characteristics of target coronary plaque were analyzed using integrated backscatter intravascular ultrasound (IB-IVUS) before and after treatment. Plasma levels of inflammatory cytokines sampled in the coronary sinus (CS) and peripheral vein were also measured. Significant increases in fibrous volume (51.2±10.4 to 58.3±7.7%, P=0.03) and reductions in lipid volume (38.4±12.4 to 32.8±9.7%, P=0.03) were observed on IB in the telmisartan group, while there were no significant changes in the plaque component in the control group. CS levels of inflammatory cytokines (matrix metalloproteinase [MMP]3, tumor necrosis factor-, high-sensitivity C-reactive protein and MMP9) were lower after than before treatment in the only telmisartan group (7.7±6.1 to 5.5±4.9ng/ml, 3.1±1.9 to 2.3±2.0pg/ml, 5.6±6.0 to 2.2±2.4mg/L, 36.1±39.3 to 19.9±27.5ng/ml, P=0.02, P=0.03, P=0.04, P=0.07, respectively). Decreased local inflammatory response and plaque stabilization on IB imaging were observed after 6 months of telmisartan treatment. These findings might be associated with local anti-inflammatory and anti-arteriosclerotic effects of telmisartan.
(キーワード): Coronary plaque / Inflammatory cytokine / Integrated backscatter intravascular ultrasound / Telmisartan
(出版サイトへのリンク): ● Publication site (DOI): 10.1253/circj.CJ-13-0741
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24189463; ● CiNii @ 国立情報学研究所 (CRID): 1390282680085613824; ● Summary page in Scopus @ Elsevier: 2-s2.0-84891099318

(DOI: 10.1253/circj.CJ-13-0741, PubMed: 24189463, CiNii: 1390282680085613824, Elsevier: Scopus) A Takashima, Takayuki Ise, Shusuke Yagi, Takashi Iwase, S Kimura, Yuka Ueda, K Nishikawa, A Ishii, Toshiyuki Niki, Koji Yamaguchi, Yoshio Taketani, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Shinsuke Katoh, Masashi Akaike and Masataka Sata :
Cardiac rehabilitation reduces serum levels of oxidized low-density lipoprotein.,
Circulation Journal, Vol.78, No.11, 2682-2687, 2014.

(要約): BACKGROUND: Oxidized low-density lipoprotein (oxLDL) levels have been found to play an important role in the progression of atherosclerosis. However, methods for effectively reducing oxLDL levels have not been established. Comprehensive cardiac rehabilitation (CR) with exercise training prevents the progression of atherosclerosis, and might reduce oxLDL levels.MethodsandResults:We measured the serum levels of malondialdehyde-modified LDL (MDA-LDL), a marker of oxLDL, in 136 patients who were enrolled in a 6-month CR program. Peak oxygen consumption (VO2) and MDA-LDL levels were analyzed, before and 6 months after enrolment. In total, 67 patients completed the CR program (CR group) and 69 patients failed to complete the program (non-CR group). Peak VO2increased significantly in the CR group (P<0.01). The levels of MDA-LDL decreased significantly in the CR group (P<0.01) but not in the non-CR group. VO2(peak VO2after CR-peak VO2before CR) was negatively associated with MDA-LDL (MDA-LDL after CR-MDA-LDL before CR) (R(2)=0.11, P=0.01). Multiple regression analysis showed that continuing CR was an independent determining factor for lowering MDA-LDL levels.CONCLUSIONS: CR decreases oxLDL levels in patients with cardiovascular diseases. Moreover, CR may prevent cardiovascular events through an antioxidative effect. (Circ J 2014; 78: 2682-2687).
(キーワード): Cardiac rehabilitation / Lipoproteins / Oxidative stress
(徳島大学機関リポジトリ): ● Metadata: 109368
(出版サイトへのリンク): ● Publication site (DOI): 10.1253/circj.CJ-14-0532
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25241889; ● Search Scopus @ Elsevier (PMID): 25241889; ● Search Scopus @ Elsevier (DOI): 10.1253/circj.CJ-14-0532

(徳島大学機関リポジトリ: 109368, DOI: 10.1253/circj.CJ-14-0532, PubMed: 25241889) Kenya Kusunose, N Tomita, S Nishio, Mika Bando, S Hayashi, Junko Hotsuchi, Takashi Iwase, Hirotsugu Yamada and Masataka Sata :
Left main coronary artery compression syndrome with an incomplete atrioventricular septal defect presenting as angina induced by hyperthyroidism.,
Internal Medicine, Vol.53, No.18, 2083-2085, 2014.

(要約): We herein report the case of a 29-year-old woman who was diagnosed with incomplete atrioventricular septal defect and extrinsic compression of the left main coronary artery (LMCA) with chest pain due to postpartum thyroiditis. She exhibited chest pain with ST elevation, and coronary computed tomography showed that the LMCA was compressed between the dilated pulmonary artery and aorta. After her hyperthyroidism was treated, her chest pain resolved. Surgical repair of endocardiosis and coronary bypass grafting were performed. On the one-year follow-up visit, the dilation of the pulmonary artery and right heart was decreased. It is important to consider the possibility of compression of the LMCA in patients presenting with pulmonary hypertension and chest pain.
(キーワード): left main compression syndrome / congenital heart disease / postpartum thyroiditis
(出版サイトへのリンク): ● Publication site (DOI): 10.2169/internalmedicine.53.2403
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25224192; ● CiNii @ 国立情報学研究所 (CRID): 1390282679850242944; ● Summary page in Scopus @ Elsevier: 2-s2.0-84907454931

(DOI: 10.2169/internalmedicine.53.2403, PubMed: 25224192, CiNii: 1390282679850242944, Elsevier: Scopus) Takeshi Soeki, S Bando, E Uematsu, T Matsuura, Toshiyuki Niki, Takayuki Ise, Kenya Kusunose, Junko Hotsuchi, Yuka Ueda, N Tomita, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Pentraxin 3 is a local inflammatory marker in atrial fibrillation.,
Heart and Vessels, Vol.29, No.5, 653-658, 2014.

(要約): Increasing evidence indicates that inflammation contributes to the pathogenesis of atrial fibrillation (AF). Pentraxin 3 (PTX3) is produced abundantly in local inflammatory lesions while C-reactive protein (CRP) is produced mainly in the liver. In this study, we investigated whether a local level of PTX3 might be a sensitive marker for the local inflammation of AF. Blood from the periphery and left atrial appendage (LAA) was sampled from 23 patients with AF undergoing pulmonary vein isolation, and from 10 control subjects with Wolff-Parkinson-White syndrome. We measured peripheral and LAA plasma concentrations of CRP, interleukin-6 (IL-6), tumor necrosis factor- (TNF-), and PTX3. Plasma PTX3 concentrations in both locations were higher in patients with AF than in control subjects. PTX3 concentrations were significantly higher in the LAA than the periphery in patients with AF (3.7 ± 1.4 vs 3.3 ± 1.2 ng/ml, P < 0.01), but not in control subjects (2.4 ± 0.5 vs 2.4 ± 0.5 ng/ml, not significant). Patients and controls showed no significant differences in CRP, IL-6, or TNF- concentrations between the periphery and LAA. Interestingly, there was a significant positive correlation between LAA plasma concentrations of PTX3 and left atrial volume (r = 0.55, P < 0.01). These data demonstrate that Local PTX3 production in the left atrium might reflect the local inflammation of AF.
(キーワード): Pentraxin 3 / Atrial fibrillation / 炎症 (inflammation)
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s00380-013-0400-8
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23979265; ● Summary page in Scopus @ Elsevier: 2-s2.0-84929517476

(DOI: 10.1007/s00380-013-0400-8, PubMed: 23979265, Elsevier: Scopus) S Nishio, Kenya Kusunose, Hirotsugu Yamada, Junko Hotsuchi, S Hayashi, Mika Bando, Y Saijo, Y Hirata, M Abe and Masataka Sata :
Multimodality imaging of biatrial myxomas in an asymptomatic patient.,
Journal of Cardiology Cases, Vol.10, No.3, 85-87, 2014.

(要約): Myxomas are located in the left atrium in 7580% of cases and almost always present with signs and symptoms of a thromboembolic event. Biatrial myxomas are rare, and their incidence is generally less than 2.5% of all myxomas. We herein present a case of biatrial myxomas as an incidental finding by echocardiography where the patient underwent surgery. Echocardiography continues to be the initial imaging modality for intracardiac masses. Cardiac magnetic resonance provides superior tissue characterization, particularly important in differentiating a myxoma from a thrombus. Appropriate use of these non-invasive imaging modalities may lead to a correct diagnosis and good outcome.
(キーワード): Myxoma / 経食道心エコー (transesophageal echocardiography) / Cardiac magnetic resonance imaging / Atrium
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jccase.2014.03.009
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1016/j.jccase.2014.03.009

(DOI: 10.1016/j.jccase.2014.03.009) T Hara, K Kishi-Tanaka, Takashi Iwase, Hirotsugu Yamada, Masashi Akaike and Masataka Sata :
Utility of lower limb positive pressure test for diagnosis of diastolic heart failure: a case report.,
The Journal of Medical Investigation : JMI, Vol.61, No.3-4, 404-408, 2014.

(要約): A 70-year-old woman with dyspnea on exertion was admitted to our hospital. She had a history of apical hypertrophic cardiomyopathy (HCM) and repeated hospitalization for heart failure. Results of physical examination were normal except for leg edema. Echocardiography showed apical HCM with preserved LV systolic function (LVEF = 70%). Although dyspnea on exertion and leg edema improved rapidly with the use of diuretics, her symptoms soon worsened when daily activity was started again. In order to examine the effect of preload on hemodynamics, we performed a lower limb positive pressure test by compressing both legs using a household air leg massager. Echocardiography showed increases in mitral E velocity, E/A ratio and pulmonary venous D flow as well as decrease in stroke volume during the lower limb positive pressure test. Simultaneously-recorded pressure study also showed elevated LVEDP and increased v wave of pulmonary capillary wedge pressure. These results suggested that even a small increase in preload led to elevation of LVEDP and symptomatic worsening due to severe diastolic heart failure in the present case. The lower limb positive pressure test may be useful for assessing the effect of preload on hemodynamics in patients with diastolic heart failure.
(キーワード): diastolic heart failure / lower limb positive pressure test / apical hypertrophic cardiomyopathy
(徳島大学機関リポジトリ): ● Metadata: 109593
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.61.404
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25264062; ● CiNii @ 国立情報学研究所 (CRID): 1390282679219954688; ● Summary page in Scopus @ Elsevier: 2-s2.0-84907518768

(徳島大学機関リポジトリ: 109593, DOI: 10.2152/jmi.61.404, PubMed: 25264062, CiNii: 1390282679219954688, Elsevier: Scopus) Michio Shimabukuro, C. Okawa, X. F. Lei, J. R. Kim-Kaneyama, Hirotsugu Yamada, Hirotsugu Kurobe, Daiju Fukuda, M. Sato, Tetsuya Kitagawa and Masataka Sata :
Effects of ezetimibe on oxidized cholesterol components in epicardial fat and myocardium: a gas chromatography-mass spectrometry analysis,
Atherosclerosis, Vol.235, No.2, 113, 2014.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.atherosclerosis.2014.05.307
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1016/j.atherosclerosis.2014.05.307

(DOI: 10.1016/j.atherosclerosis.2014.05.307) Hirotsugu Yamada, Kenya Kusunose, S Nishio, Mika Bando, Junko Hotsuchi, S Hayashi, Takayuki Ise, Shusuke Yagi, Koji Yamaguchi, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Pre-load stress echocardiography for predicting the prognosis in mild heart failure.,
JACC. Cardiovascular Imaging, Vol.7, No.7, 641-649, 2014.

(キーワード): Doppler echocardiography / heart failure / leg-positive pressure / stress echocardiography / survival
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jcmg.2014.04.009
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24954460; ● Summary page in Scopus @ Elsevier: 2-s2.0-84904576445

(DOI: 10.1016/j.jcmg.2014.04.009, PubMed: 24954460, Elsevier: Scopus) S Bando, Takeshi Soeki, T Matsuura, Toshiyuki Niki, Takayuki Ise, Koji Yamaguchi, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Masashi Akaike, T Aiba, W Shimizu and Masataka Sata :
Congenital long QT syndrome with compound mutations in the KCNH2 gene.,
Heart and Vessels, Vol.29, No.4, 554-559, 2014.

(要約): Congenital long QT syndrome is a genetic disorder encompassing a family of mutations that can lead to aberrant ventricular electrical activity. We report on two brothers with long QT syndrome caused by compound mutations in the KCNH2 gene inherited from parents who had no prolonged QT interval on electrocardiography. The proband had syncope, and his elder brother suffered from ventricular fibrillation. Genetic testing revealed that both brothers had multiple mutations in the KCNH2 gene, including a missense mutation of C1474T (exon 6) as well as a frameshift/nonsense mutation, resulting from the insertion of 25 nucleotides, which caused an altered amino acid sequence beginning at codon 302 and a premature termination codon (i.e., TAG) at codon 339 (exon 4). Family genetic screening found that their father had the same frameshift mutation, and their mother and sister had the same missense mutation, in the KCNH2 gene. However, these other family members were asymptomatic, with normal QT intervals on electrocardiography. These results suggest that compound mutations in the KCNH2 gene inherited independently from the parents made the phenotypes of their sons more severe.
(キーワード): KCNH2 gene / Long QT syndrome / Compound mutation / Missense mutation / Frameshift mutation
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s00380-013-0406-2
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24057343; ● Summary page in Scopus @ Elsevier: 2-s2.0-84904036858

(DOI: 10.1007/s00380-013-0406-2, PubMed: 24057343, Elsevier: Scopus) S Hayashi, Hirotsugu Yamada, Mika Bando, Junko Hotsuchi, Takayuki Ise, Koji Yamaguchi, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Toshiaki Tamaki and Masataka Sata :
Augmentation Index does not Reflect the Risk of Coronary Artery Disease in Elderly Patients.,
Circulation Journal, Vol.78, No.5, 1176-1182, 2014.

(要約): BACKGROUND: Augmentation index (AI) has been used as a clinical index of arterial stiffness and has been reported to be an independent predictor of cardiovascular events, but some investigators have reported that AI is not a useful marker to identify coronary artery disease (CAD) in elderly patients. The majority of CAD patients are elderly people, therefore the aim of this study was to examine whether AI is a useful marker to identify the risk of CAD.METHODS AND RESULTS: A total of 120 patients (69±10 years of age; 83 male) who underwent cardiac catheterization for suspected CAD were enrolled. Invasive central blood pressure (BP) was measured using a fluid-filled catheter. Non-invasive AI was calculated by the SphygmoCor (AtCor Medical) system at the end of catheterization. Subjects consisted of 99 patients with CAD and 21 patients without CAD. There was no significant difference in AI between the CAD and the non-CAD groups (24±10 vs. 24±14%). Non-invasive systolic central BP was lower than the invasive systolic central BP (115±18 vs. 130±23 mmHg, P<0.001) in all patients. Non-invasive diastolic central BP was greater than the invasive diastolic central BP (67±10 vs. 63±10 mmHg, P<0.001).CONCLUSIONS: In elderly patients, AI may not be a useful marker to identify CAD
(キーワード): Arterial stiffness / Augmentation index / Central blood pressure / Coronary artery disease
(徳島大学機関リポジトリ): ● Metadata: 106070
(出版サイトへのリンク): ● Publication site (DOI): 10.1253/circj.CJ-13-1422
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24562676; ● CiNii @ 国立情報学研究所 (CRID): 1390001205107150592; ● Summary page in Scopus @ Elsevier: 2-s2.0-84899659435

(徳島大学機関リポジトリ: 106070, DOI: 10.1253/circj.CJ-13-1422, PubMed: 24562676, CiNii: 1390001205107150592, Elsevier: Scopus) Kenya Kusunose, T Chono, Tomotsugu Tabata, Hirotsugu Yamada and Masataka Sata :
Echocardiographic image tracker with a speckle adaptive noise reduction filter for the automatic measurement of the left atrial volume curve.,
European Heart Journal Cardiovascular Imaging, Vol.15, No.5, 509-514, 2014.

(要約): Aims: Since tracking accuracy in left atrial (LA) images decreases due to low image quality around the LA in the apical view, a practical tracking method for LA images has not yet been proposed. The aim of this study was to assess an accurate and high-speed LA volume tracking (LAVT) method for the automatic measurement of LA volume (LAV) curves. Methods and results: We used three approved protocols in this study: (i) LAV curves were measured by LAVT on computer-simulated images; (ii) in 20 healthy volunteers, we assessed the feasibility and accuracy of this method compared with expert's measurements; and (iii) echocardiography and multi-detector row computed tomography (MDCT) imaging were performed on the same day in 20 patients with suspected coronary artery disease. On computer-simulated images, mean absolute percentage LAVT error in one cardiac cycle was 3% in filtered images and 16% in original images. In 20 healthy volunteers, there are strong correlations between LAVT and the expert's LA measurements (LA maximum volume; R = 0.93, P < 0.001). In 400 LA images with 20 patients, an excellent correlation was obtained between LAVs using echocardiography and MDCT (R = 0.98, P < 0.001), with a small bias (14% of the mean) and narrow limits of agreement (+15% of the mean). The mean time required for the LAVT analysis was 1.8 min, for the MDCT analysis was 35.8 min, and for the manual echocardiographic analysis was 14.0 min. Conclusion: This LAVT method is fast, valid, accurate, and reproducible for determining LAV in both simulated images and the clinical setting.
(キーワード): 経食道心エコー (transesophageal echocardiography) / Image tracking / Left atrium / Speckle / 雑音抑圧 (noise reduction)
(出版サイトへのリンク): ● Publication site (DOI): 10.1093/ehjci/jet196
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24165117; ● Summary page in Scopus @ Elsevier: 2-s2.0-84898856089

(DOI: 10.1093/ehjci/jet196, PubMed: 24165117, Elsevier: Scopus) Takayuki Ise, Takashi Iwase, S Masuda, Shusuke Yagi, Masashi Akaike, S Nishio, Toshiyuki Niki, Koji Yamaguchi, Yoshio Taketani, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Acute pulmonary thromboembolism from deep vein thrombosis induced by trauma to the popliteal vein with a tennis racket.,
Journal of Cardiology Cases, Vol.9, No.4, 162-164, 2014.

(要約): Acute pulmonary thromboembolism (PTE) is mainly caused by deep vein thrombosis (DVT) and sometimes leads to a fatal outcome. Few cases of sport-related lower extremity DVT, involving direct external trauma, have been reported. A 58-year-old man, without any risk factors for thromboembolism suffered acute PTE from DVT after playing tennis. A detailed history revealed that he had hit his popliteal vein with each swing of his tennis racket and the site of the trauma, at popliteal fossa, was exactly the same as the site of the DVT formation. Therefore, the cause of DVT was suspected to be the repeated trauma to the popliteal vein. The repeated external trauma to the popliteal vein may have caused vascular endothelial damage, leading to DVT.
(キーワード): Acute pulmonary thromboembolism / Deep vein thrombosis / Trauma
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jccase.2014.01.001
(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-84897413698

(DOI: 10.1016/j.jccase.2014.01.001, Elsevier: Scopus) 田畑良, 山田博胤, 西尾進, 井口明子, 小幡史明, 中西嘉憲, 河南真吾, 湯浅志乃, 清水伸彦, 山口治隆, 河野光宏, 佐田政隆, 谷憲治, 坂東弘康, 申輝樹 :
心エコー検査におけるリアルタイム遠隔診断支援システムの開発および運用経験,
月刊地域医学, Vol.28, No.3, 236-240, 2014年.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1523106604839480448

(CiNii: 1523106604839480448) 中山泰介, 木下肇, 菅野幹雄, 黒部裕嗣, 神原保, 北市隆, 山田博胤, 佐田政隆, 藤田博, 曽我部仁史, 北川哲也 :
ペースメーカーリード前尖穿通に伴う重症三尖弁閉鎖不全症に対する1手術例,
心臓, Vol.46, No.3, 378-383, 2014年.

(出版サイトへのリンク): ● Publication site (DOI): 10.11281/shinzo.46.378
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.11281/shinzo.46.378

(DOI: 10.11281/shinzo.46.378) Kazumi Takaishi, Shinji Kawahito, Hirotsugu Yamada, Takeshi Soeki, Masataka Sata and Hiroshi Kitahata :
Increase in prominence of electrocardiographic J waves after a single dose of propofol in a patient with early ventricular repolarisation.,
Anaesthesia, Vol.69, No.2, 170-175, 2014.

(要約): J waves appear on an electrocardiogram as an elevation of the J point in the terminal portion of the QRS complex. J waves are often benign, but may be associated with malignant ventricular arrhythmias. In some cases, such problems appear to have been precipitated by propofol infusions. We observed a sudden increase in J waves and profound hypotension following a single intravenous dose of propofol in an 84-year-old woman with early repolarisation in the inferior ventricular wall. When early repolarisation (as shown by electrocardiographic J waves) is observed in the inferior ventricular wall pre-operatively, patients should be carefully monitored. Myocardial ischaemia and the use of drugs that might worsen J waves should be avoided.
(キーワード): Aged, 80 and over / Anesthetics, Intravenous / Electrocardiography / Female / Humans / Hypotension / Intraoperative Complications / Monitoring, Intraoperative / Propofol / Ventricular Fibrillation
(出版サイトへのリンク): ● Publication site (DOI): 10.1111/anae.12448
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24116860; ● Summary page in Scopus @ Elsevier: 2-s2.0-84892799834

(DOI: 10.1111/anae.12448, PubMed: 24116860, Elsevier: Scopus) R Tamai, T Hara, Hirotsugu Yamada, S Nishio, M Bando, J Hotchi, S Hayashi, Toshiyuki Niki, Tetsuya Kitagawa and Masataka Sata :
Massive tricuspid regurgitation due to pacemaker-lead puncture of the tricuspid valve: successful diagnosis by 3-dimensional echocardiography.,
Journal of Medical Ultrasonics, Vol.41, No.1, 69-71, 2014.

(要約): An 83-year-old woman presented to our echocardiographic center with symptoms of right heart failure. A dual-chamber DDDR pacemaker had been implanted 9 years earlier. Two-dimensional echocardiography revealed right atrial and ventricular enlargement and massive tricuspid regurgitation with immobilization of the anterior leaflet of the tricuspid valve. Three-dimensional transesophageal echocardiography showed that the pacemaker lead had punctured the leaflet. These echocardiographic findings were confirmed during surgery. The pacemaker lead was transected and removed, and pericardial patch closure of the leaflet hole and tricuspid annuloplasty were performed. The mechanism of regurgitation was elucidated by real-time three-dimensional echocardiography, and surgical repair was straightforward.
(キーワード): Pacemaker-lead puncture / Tricuspid regurgitation / 3-Dimensional echocardiography
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s10396-013-0459-y
(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-84893154861

(DOI: 10.1007/s10396-013-0459-y, Elsevier: Scopus) Hayato Nose, Hideki Otsuka, Youichi Otomi, K Terazawa, Shoichiro Takao, Seiji Iwamoto, Takashi Iwase, Hirotsugu Yamada, Masataka Sata and Masafumi Harada :
The physiological uptake pattern of (18)F-FDG in the left ventricular myocardium of patients without heart disease.,
The Journal of Medical Investigation : JMI, Vol.61, No.1, 2, 53-58, 2014.

(要約): Purpose: The purpose of this study was to evaluate the physiological uptake pattern of 18F-FDG in the left ventricular myocardium of patients under preparation for tumor FDG-PET. Patients and Methods: We enrolled 188 patients without cardiac disease. The accumulation patterns were classified as either none, diffuse, focal or focal on diffuse. When a focal uptake was only observed on the basal wall, then the patterns were classified as having either a ring, over half or spot uptake. Results: The frequencies of the myocardial FDG uptake patterns were as follows: none, n=52 (27.7%); diffuse, n=63 (33.5%); focal on diffuse, n=40 (21.3%) and focal, n=33 (17.6%). The age, blood glucose level, weight and dose of FDG did not differ significantly for each pattern. The focal and focal on diffuse patterns were seen in 73 patients, and 65 patients had a focal uptake only on the basal wall; ring uptake in 29 patients, over half in 20 and spot uptake in 16 patients. Conclusions: The physiological myocardial uptake showed several patterns. Focal uptake was often seen in patients with cardiac disease, but it did not always indicate an abnormal finding when the accumulation was only on the basal wall.
(キーワード): F-FDG PET / heart / physiological myocardial uptake / fasting state
(徳島大学機関リポジトリ): ● Metadata: 109517
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.61.53
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24705749; ● Search Scopus @ Elsevier (PMID): 24705749; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.61.53

(徳島大学機関リポジトリ: 109517, DOI: 10.2152/jmi.61.53, PubMed: 24705749) Takeshi Soeki, Toshiyuki Niki, E. Uematsu, S. Bando, T. Matsuura, Kenya Kusunose, Takayuki Ise, Yuka Ueda, N. Tomita, Koji Yamaguchi, Kunihiko Koshiba, Shusuke Yagi, Daiju Fukuda, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Masashi Akaike, Michio Shimabukuro, I. Kishimoto, Kenji Kangawa and Masataka Sata :
Ghrelin protects the heart against ischemia-induced arrhythmias by preserving connexin-43 protein.,
Heart and Vessels, Vol.28, No.6, 795-801, 2013.

(要約): Vagal nerve stimulation has been postulated to confer an antifibrillatory effect. We studied whether ghrelin administration would exert an antiarrhythmic effect via modulation of autonomic nerve activity in rats after acute myocardial ischemia (MI). Male Sprague-Dawley rats were exposed to 30 min of ischemia following ligation of the left coronary artery. Animals were then randomized to receive either ghrelin (n = 26) or saline (n = 26) during the period of coronary ligation. Power spectral analysis of heart-rate variability revealed that the administration of ghrelin increased the high-frequency (HF) power and decreased the low-frequency (LF)/HF ratio. Ventricular tachyarrhythmias were less frequent in rats after MI who received ghrelin in comparison with rats that received saline. Immunoblotting and immunohistochemistry revealed that rats given saline alone during MI exhibited a marked reduction in phosphorylated connexin-43 within the left ventricle, whereas those that received ghrelin displayed only minor reductions in comparison with sham-operated rats. These effects of ghrelin were diminished by the coadministration of atropine or the blockade of vagal afferents. These data demonstrate that the beneficial effect of ghrelin might be mediated by modulation of cardiac autonomic nerve activity.
(キーワード): Animals / Anti-Arrhythmia Agents / Atropine / Connexin 43 / Disease Models, Animal / Ghrelin / Heart Rate / Heart Ventricles / Male / Muscarinic Antagonists / Myocardial Ischemia / Phosphorylation / Rats / Rats, Sprague-Dawley / Tachycardia, Ventricular / Time Factors / Vagotomy / Vagus Nerve
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s00380-013-0333-2
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23494606; ● Search Scopus @ Elsevier (PMID): 23494606; ● Search Scopus @ Elsevier (DOI): 10.1007/s00380-013-0333-2

(DOI: 10.1007/s00380-013-0333-2, PubMed: 23494606) Hirotsugu Yamada :
Report of the American College of Cardiology (ACC) Scientific Sessions 2013,San Francisco - Highlighting Late-Breaking Trials -,
Circulation Journal, Vol.77, No.5, 1139-1145, 2013.

(要約): The American College of Cardiology's (ACC) 62nd Annual Scientific Session was held at the Moscone Center, San Francisco, from March 9-11, 2013. The meeting focused on the "transformation of cardiovascular care, from discovery to delivery", featured over 20 late-breaking clinical trials and 2,000 abstracts. These sessions gave notable exposure and recognition of studies likely to significantly affect clinical practice. There were 21 trials scheduled for presentation in 5 featured Late-Breaking Clinical Trial sessions, but one, the PREVAIL trial, was not presented because of a failure to observe an embargo. I summarize and overview both the late-breaking trials presented at ACC 2013 and the PREVAIL trial. (Circ J 2013; 77: 1139-1145)
(キーワード): American College of Cardiology / Congress / Late-breaking clinical trials
(出版サイトへのリンク): ● Publication site (DOI): 10.1253/circj.CJ-13-0395
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23558827; ● CiNii @ 国立情報学研究所 (CRID): 1390001205105679360; ● Summary page in Scopus @ Elsevier: 2-s2.0-84876748458

(DOI: 10.1253/circj.CJ-13-0395, PubMed: 23558827, CiNii: 1390001205105679360, Elsevier: Scopus) Shusuke Yagi, Masashi Akaike, Ken-ichi Aihara, Daiju Fukuda, Masayoshi Ishida, Takayuki Ise, Toshiyuki Niki, Yuka Ueda, Koji Yamaguchi, Takashi Iwase, Yoshio Taketani, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Pharmacology of Aldosterone and the Effects of Mineralocorticoid Receptor Blockade on Cardiovascular Systems.,
Acta Cardiologica Sinica, Vol.29, No.3, 201-207, 2013.

(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-84878307366

(Elsevier: Scopus) Kenya Kusunose, Hirotsugu Yamada, S. Nishio, N. Tomita, Toshiyuki Niki, Koji Yamaguchi, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Interval from the Onset of Transmitral Flow to Annular Velocity Is a Marker of LV Filling Pressure.,
JACC. Cardiovascular Imaging, Vol.6, No.4, 528-530, 2013.

(キーワード): Angina, Stable / Atrial Function, Left / Atrial Pressure / Cardiac Catheterization / Case-Control Studies / Echocardiography, Doppler, Color / Humans / Mitral Valve / Multivariate Analysis / Predictive Value of Tests / Prospective Studies / Time Factors / Ventricular Function, Left / Ventricular Pressure
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jcmg.2012.10.025
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23579016; ● Search Scopus @ Elsevier (PMID): 23579016; ● Search Scopus @ Elsevier (DOI): 10.1016/j.jcmg.2012.10.025

(DOI: 10.1016/j.jcmg.2012.10.025, PubMed: 23579016) N Tomita, Hirotsugu Yamada, S Nishio, R Tamai, Kenya Kusunose, S Hayashi, Junko Hotsuchi and Masataka Sata :
Patent foramen ovale diagnosed by real-time three-dimensional contrast transesophageal echocardiography: A case report.,
Journal of Cardiology Cases, Vol.7, No.4, e91-e92, 2013.

(要約): A 67-year-old man was admitted due to insensitiveness of right upper limb and dysarthria, and treated for suspected lacunar infarction or branch atherosclerotic disease. Carotid ultrasonography showed no abnormalities, and agitated contrast transesophageal echocardiography was performed to detect patent foramen ovale (PFO). Intravenously administered microbubbles did not appear in left atrium by 2-dimensional echocardiography, while contrasts were observed in left atrium using 3-dimensional echocardiography. Real-time 3-dimensional contrast transesophageal echocardiography may be the most useful method for the diagnosis of small PFO.
(キーワード): Three-dimensional transesophageal echocardiography / Contrast echocardiography / Patent foramen ovale / Agitated saline bubble
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jccase.2012.10.011
(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-84876475886

(DOI: 10.1016/j.jccase.2012.10.011, Elsevier: Scopus) Tomoya Hara, Hirotsugu Yamada, Akira Takashima, Hiromu Yamasaki, Kozue Ogasawara, Sachiko Bando, Takayuki Ise, Toshiyuki Niki, Kenya Kusunose, Yuka Ueda, Noriko Tomita, Koji Yamaguchi, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Hidehisa Horiguchi, Naomi Sakashita and Masataka Sata :
Constrictive pericarditis with intrapericardial abscess.,
Circulation Journal, Vol.77, No.3, 786-788, 2013.

(キーワード): Abscess / Aged / Autopsy / Fatal Outcome / Heart Diseases / Humans / Male / Methicillin-Resistant Staphylococcus aureus / Pericarditis, Constrictive / Pericardium / Staphylococcal Infections
(出版サイトへのリンク): ● Publication site (DOI): 10.1253/circj.CJ-12-1098
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23207988; ● Summary page in Scopus @ Elsevier: 2-s2.0-84874412877

(DOI: 10.1253/circj.CJ-12-1098, PubMed: 23207988, Elsevier: Scopus) N. Kawano, Koji Yamaguchi, Toshiyuki Niki, Yamamoto Takashi, Takashi Iwase, Yoshio Taketani, Takayuki Ise, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, K Kawano, A. Kakutani and Masataka Sata :
Two cases of acute myocardial infarction during combined chemotherapy in young patients with testicular cancer.,
Journal of Cardiology Cases, Vol.7, No.6, e176-e180, 2013.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jccase.2013.02.009
(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-84877831795

(DOI: 10.1016/j.jccase.2013.02.009, Elsevier: Scopus) 高島啓, 伊勢孝之, 上田由佳, 岩瀬俊, 八木秀介, 前田香代子, 西川幸治, 小笠原梢, 坂東美佳, 坂東左知子, 冨田紀子, 仁木敏之, 發知淳子, 山口浩司, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 加藤真介, 赤池雅史, 安井夏生, 佐田政隆 :
心臓リハビリテーションは酸化LDLを低下させる,
心臓リハビリテーション, Vol.18, No.1, 130-133, 2013年.

(キーワード): 酸化LDL / 心臓リハビリテーション / 心肺運動負荷試験
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1520010381154583040

(CiNii: 1520010381154583040) T Hara, Koji Yamaguchi, Takashi Iwase, M Kadota, Mika Bando, K Ogasawara, S Bando, Takayuki Ise, Toshiyuki Niki, Yuka Ueda, N Tomita, Yoshio Taketani, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Eosinophilic Myocarditis due to Churg-Strauss syndrome with markedly elevated Eosinophil Cationic Protein.,
International Heart Journal, Vol.54, No.1, 51-53, 2013.

(要約): A 67-year-old woman with asthma visited our hospital with increasing dyspnea and new-onset paresthesia and purpura in her legs. Physical examination showed a wheeze, pretibial edema, and surrounding purpura. Chest X-rays showed cardiac decompensation and an electrocardiogram revealed a new ST-T change. Laboratory data showed leukocytosis, hypereosinophilia (10,450/μL), troponin T(+), elevated BNP, and markedly elevated eosinophil cationic protein (ECP) (> 150 ng/mL). Echocardiography revealed diffuse left ventricular hypokinesis (ejection fraction 30%) with increased wall thickness. Coronary angiography was normal. Cardiac magnetic resonance imaging implied diffuse myocardial edema and subendocardial late gadolinium enhancement. Skin biopsy of purpura showed superfi cial perivascular dermatitis with remarkable eosinophilic infiltrations. No evidence of drug allergies, parasitic infection, or myeloproliferative disorder was detected. Based on these findings, a diagnosis of eosinophilic myocarditis due to Churg-Strauss syndrome was considered. She was administered prednisolone at a dose of 1 mg/kg, cyclophosphamide, and diuretics. Several markers of eosinophilic myocarditis and heart failure gradually improved, including ECP. She was discharged 30 days later with no cardiac event. Eosinophilic myocarditis is characterized by predominantly eosinophilic infi ltration. Eosinophilic granule proteins, such as ECP and major basic protein, play important roles in the pathogenesis of eosinophilic myocarditis. We experienced a rare case of eosinophilic myocarditis due to Churg-Strauss syndrome. Markedly elevated ECP played an important role in the early diagnosis and subsequent reduction in ECP served as a marker of monitoring. In an asthmatic patient with dyspnea, hypereosinophilia, and vasculitis, Churg-Strauss syndrome with eosinophilic myocarditis should be considered.
(出版サイトへのリンク): ● Publication site (DOI): 10.1536/ihj.54.51
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23428926; ● Search Scopus @ Elsevier (PMID): 23428926; ● Search Scopus @ Elsevier (DOI): 10.1536/ihj.54.51

(DOI: 10.1536/ihj.54.51, PubMed: 23428926) Hirata Yoichiro, Hirotsugu Kurobe, Uematsu Etsuko, Shusuke Yagi, Takeshi Soeki, Hirotsugu Yamada, Daiju Fukuda, Michio Shimabukuro, Nakayama Mizuho, Matsumoto Kunio, Sakai Yoshiki, Tetsuya Kitagawa and Masataka Sata :
Beneficial effect of a synthetic prostacyclin agonist, ONO-1301, in rat autoimmune myocarditis model.,
European Journal of Pharmacology, Vol.699, No.1-3, 81-87, 2013.

(要約): Injury to the heart can result in cardiomyocyte hypertrophy, fibrosis, and cell death. Myocarditis sometimes progresses to dilated cardiomyopathy. We previously reported that ONO-1301, a synthetic prostacyclin agonist with thromboxane-synthase inhibitory activity, promotes production of hepatocyte growth factor (HGF) from various cell types and ameliorates ischemia-induced left ventricle dysfunction in the mouse, rat and pig. Here, we investigated the therapeutic efficacy of ONO-1301 in a rat model of myosin-induced experimental autoimmune myocarditis, in which the heart transits from an acute inflammatory phase to a chronic dilated cardiomyopathy phase. Four weeks after myosin injection to Lewis rats, ONO-1301 (6 mg/kg/day) was orally administered for 4 weeks (ONO-1301 group). Hemodynamic parameters and plasma brain natriuretic peptide (BNP) level were significantly improved by ONO-1301. Histological analysis revealed that capillary density in the myocardium was significantly increased by ONO-1301. ONO-1301 increased circulating endothelial progenitor cells (EPC) as determined by FACS analysis. These beneficial effects of ONO-1301 were partially abrogated by a neutralizing anti-HGF antibody (8 mg/kg/dose). These findings indicate beneficial effects of ONO-1301 in a rat experimental autoimmune myocarditis model.
(キーワード): 心不全 (heart failure) / HGF / dilated cardiomyopathy / experimental autoimmune myocarditis
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.ejphar.2012.11.045
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23219794; ● Search Scopus @ Elsevier (PMID): 23219794; ● Search Scopus @ Elsevier (DOI): 10.1016/j.ejphar.2012.11.045

(DOI: 10.1016/j.ejphar.2012.11.045, PubMed: 23219794) 羽星辰哉, 八木謙次, 多田恵曜, 松下展久, 兼松康久, 坂東美佳, 上田由佳, 山田博胤, 里見淳一郎, 西京子, 佐田政隆, 永廣信治 :
くも膜下出血に続発した重症のNeurogenic stress cardiomyopathyの検討,
四国医学雑誌, Vol.68, No.5, 6, 233-238, 2012年.

(キーワード): neurogenic stress cardiomyopathy / subarachnoid hemorrhage / sympathetic nerve
(徳島大学機関リポジトリ): ● Metadata: 110362
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1050865122807535872

(徳島大学機関リポジトリ: 110362, CiNii: 1050865122807535872) Shuji Hayashi, Hirotsugu Yamada, Susumu Nishio, Noriko Tomita, Junko Hotchi, Mika Bando, Maya Nakagawa, Rina Tamai, Daichi Hirota, Yukina Hirata and Masataka Sata :
Double-chambered right ventricle presenting significant outflow tract obstruction only in the right decubitus position.,
Journal of Echocardiography, Vol.10, No.4, 146-147, 2012.

(キーワード): double-chambered right ventricle / right mid-ventricular obstruction / postural change / doppler echocardiography / ventricular septal defect
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s12574-012-0145-x
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1007/s12574-012-0145-x

(DOI: 10.1007/s12574-012-0145-x) Munkhbaatar Dagvasumberel, Michio Shimabukuro, Nishiuchi Takeshi, Junji Ueno, Shoichiro Takao, Daiju Fukuda, Hirata Yoichiro, Hirotsugu Kurobe, Takeshi Soeki, Takashi Iwase, Kenya Kusunose, Toshiyuki Niki, Koji Yamaguchi, Yoshio Taketani, Shusuke Yagi, Tomita Noriko, Hirotsugu Yamada, Tetsuzo Wakatsuki, Masafumi Harada, Tetsuya Kitagawa and Masataka Sata :
Gender disparities in the association between epicardial adipose tissue volume and coronary atherosclerosis: A 3-dimensional cardiac computed tomography imaging study in Japanese subjects.,
Cardiovascular Diabetology, Vol.11, No.1, 106, 2012.

(要約): Growing evidence suggests that epicardial adipose tissue (EAT) may contribute to the development of coronary artery disease (CAD). In this study, we explored gender disparities in EAT volume (EATV) and its impact on coronary atherosclerosis. The study population consisted of 90 consecutive subjects (age: 63 ± 12 years; men: 47, women: 43) who underwent 256-slice multi-detector computed tomography (MDCT) coronary angiography. EATV was measured as the sum of cross-sectional epicardial fat area on CT images, from the lower surface of the left pulmonary artery origin to the apex. Subjects were segregated into the CAD group (coronary luminal narrowing > 50%) and non-CAD group. EATV/body surface area (BSA) was higher among men in the CAD group than in the non-CAD group (62 ± 13 vs. 33 ± 10 cm3/m2, p < 0.0001), but did not differ significantly among women in the 2 groups (49 ± 18 vs. 42 ± 9 cm3/m2, not significant). Multivariate logistic analysis showed that EATV/BSA was the single predictor for >50% coronary luminal narrowing in men (p < 0.0001). Predictors excluded were age, body mass index, hypertension, diabetes mellitus, and hyperlipidemia. Increased EATV is strongly associated with coronary atherosclerosis in men.
(キーワード): Adipose Tissue / Age Factors / Aged / Asian Continental Ancestry Group / Body Surface Area / Chi-Square Distribution / Coronary Angiography / Coronary Artery Disease / Coronary Stenosis / Female / Health Status Disparities / Humans / Japan / Logistic Models / Male / Middle Aged / Multidetector Computed Tomography / Multivariate Analysis / Pericardium / Predictive Value of Tests / Risk Assessment / Risk Factors / Severity of Illness Index / Sex Factors
(出版サイトへのリンク): ● Publication site (DOI): 10.1186/1475-2840-11-106
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22963346; ● Search Scopus @ Elsevier (PMID): 22963346; ● Search Scopus @ Elsevier (DOI): 10.1186/1475-2840-11-106

(DOI: 10.1186/1475-2840-11-106, PubMed: 22963346) Kenya Kusunose, Hirotsugu Yamada, Susumu Nishio, Noriko Tomita, Junko Hotchi, Mika Bando, Toshiyuki Niki, Koji Yamaguchi, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Index-beat Assessment of Left Ventricular Systolic and Diastolic Function during Atrial Fibrillation using Myocardial Strain and Strain Rate.,
Journal of the American Society of Echocardiography, Vol.25, No.9, 953-959, 2012.

(要約): Accurate assessment of left ventricular (LV) function in patients with atrial fibrillation (AF) remains difficult, mainly because of the beat-to-beat variability of many echocardiographic parameters. The aim of this study was to assess the hypothesis that LV function can be estimated from an index-beat echocardiographic assessment in patients with AF using myocardial strain and strain rate. A prospective study was conducted to assess 25 patients with AF (mean age, 66 ± 10 years). Peak systolic longitudinal strain (LS) and peak diastolic longitudinal strain rate (dSR) were measured using two different methods: (1) mean LS and dSR, the averages of instantaneous LS and dSR over 10 sec, and (2) index-beat LS and dSR, calculated when the ratio of the preceding (RR1) to the pre-preceding (RR2) interval was 1 (range, 0.96-1.04). These variables were compared with simultaneously measured LV pressure parameters using Millar catheters. There was a positive linear relationship between mean LS and index-beat LS at RR1/RR2 = 1 (r = 0.94, P < .001) and a positive linear relationship between mean dSR and index-beat dSR (r = 0.69, P < .001). Index-beat LS was correlated with the maximal positive derivative of LV pressure (peak +dP/dt) (r = -0.73, P < .001). Index-beat dSR was correlated with the time constant of isovolumic LV pressure decay (τ) (r = -0.63, P < .001). To investigate the independent predictors of τ, a stepwise multilinear regression analysis showed that index-beat dSR was the best predictor of τ. Index-beat parameters accurately reflect the mean values of parameters in patients with AF. These noninvasively obtained index-beat parameters are useful to assess surrogate LV function even in patients with AF.
(キーワード): Aged / Atrial Fibrillation / Diastole / Echocardiography, Doppler / Female / Heart Rate / Hemodynamics / Humans / Male / Myocardial Contraction / Prospective Studies / Regression Analysis / Reproducibility of Results / Systole
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.echo.2012.06.009
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22763085; ● Search Scopus @ Elsevier (PMID): 22763085; ● Search Scopus @ Elsevier (DOI): 10.1016/j.echo.2012.06.009

(DOI: 10.1016/j.echo.2012.06.009, PubMed: 22763085) T. Hara, Takeshi Soeki, Toshiyuki Niki, Kenya Kusunose, Koji Yamaguchi, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Tetsuzo Wakatsuki and Masataka Sata :
Bicuspid aortic valve endocarditis complicated by perivalvular abscess.,
The Journal of Medical Investigation : JMI, Vol.59, No.3,4, 261-265, 2012.

(要約): A 37-year-old man presenting with fever and chest pain was admitted to our hospital. Electrocardiogram showed sinus tachycardia and complete left bundle branch block. Transthoracic echocardiogram showed infective endocarditis in the bicuspid aortic valve, complicated by multiple hyperechoic vegetations and severe aortic regurgitation. Blood cultures were negative and intravenous empiric antibiotic therapy was begun. However, fever lasted for 7 days and follow-up echocardiography revealed a newly emerged perivalvular abscess. The patient eventually underwent an urgent aortic root replacement that confirmed the echocardiographic findings. Our case report emphasizes that all patients with suspected aortic valve endocarditis should undergo early and follow-up echocardiographic studies.
(キーワード): bicuspid aortic valve / infectious endocarditis / perivalvular abscess / echocardiography
(徳島大学機関リポジトリ): ● Metadata: 106030
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.59.261
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23037197; ● Search Scopus @ Elsevier (PMID): 23037197; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.59.261

(徳島大学機関リポジトリ: 106030, DOI: 10.2152/jmi.59.261, PubMed: 23037197) 坂東美佳, 山田博胤, 西尾進, 玉井利奈, 平田有紀奈, 弘田大智, 中川摩耶, 林修司, 冨田紀子, 發知淳子, 小笠原梢, 高島啓, 山崎宙, 坂東左知子, 伊勢孝之, 仁木敏之, 上田由佳, 山口浩司, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 佐田政隆, 兼松康久, 里見淳一郎, 永廣信治 :
脂質低下療法による頸動脈プラーク安定化の評価:超音波integrated backscatterを用いたカラーマッピングシステムの開発と臨床応用症例報告 (第28回徳島医学会賞受賞論文),
四国医学雑誌, Vol.68, No.3-4, 147-152, 2012年.

(要約): Background : The carotid plaque vulnerability is related to myocardial and cerebral infarction.We intended to develop an imaging system which enables to visualize tissue characteristics in thecarotid plaques based on ultrasound integrated backscatter(IB). And to test its clinical efficacy,effect of the statin therapy on the plaques was evaluated with our software. Methods and Results :Carotid ultrasound examination was performed and ultrasonographic RAW data of the plaqueswere obtained from8patients undergoing carotid artery endarterectomy. Tissue characteristicsin the plaques of resected examples were compared with preoperative ultrasonic images and thetissue IB values corresponding to the specimens were determined for developing our imaging system.Using this system, Color-coded maps of plaques in the three patients were constructed beforeand after lipid lowing therapy. We could demonstrate that lipid fraction in each plaque decreasedand fibrous or calcification fraction increased in the follow-up study. Conclusions : Changes inhistology of carotid plaques by statin could visualized with our imaging system. This techniquemay become a useful tool for the management of atherosclerosis.
(キーワード): IBS (integrated backscatter) / carotid plaque / CEA (carotid endarterectomy)
(徳島大学機関リポジトリ): ● Metadata: 102836
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1050302172854564352

(徳島大学機関リポジトリ: 102836, CiNii: 1050302172854564352) 山田聡, 岩野弘幸, 大手信之, 瀬尾由広, 山田博胤, 石津智子, 楠瀬賢也, 若見和明, 三神大世, 筒井裕之 :
心エコー図法による左室弛緩能と充満圧の評価の限界:多施設共同研究SMAPからの中間報告,
超音波医学, Vol.39, No.4, 449-456, 2012年.

(キーワード): diastolic function / e' / echocardiography / left ventricular filling pressure / relaxation
(出版サイトへのリンク): ● Publication site (DOI): 10.3179/jjmu.39.449
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390001205199417728; ● Search Scopus @ Elsevier (DOI): 10.3179/jjmu.39.449

(DOI: 10.3179/jjmu.39.449, CiNii: 1390001205199417728) 久岡白陽花, 上田由佳, 前田香代子, 西川幸治, 坂東左知子, 林修司, 竹内秀和, 仁木敏之, 楠瀬賢也, 山口浩司, 冨田紀子, 岩瀬俊, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 髙田信二郎, 赤池雅史, 安井夏生, 佐田政隆 :
(若手優秀演題セッション)尿中アルブミン排泄量に及ぼす心臓リハビリテーションの効果,
心臓リハビリテーション, Vol.17, No.1, 159-161, 2012年. Yoichiro Hirata, Michio Shimabukuro, Etsuko Uematsu, Takeshi Soeki, Hirotsugu Yamada, Yoshiki Sakai, Mizuho Nakayama, Kunio Matsumoto, Takashi Igarashi and Masataka Sata :
A synthetic prostacyclin agonist thrombozane synthase inhibitory activity, ONO-1301, protects myocardium from ischemia/reperfusion injury.,
European Journal of Pharmacology, Vol.674, No.2-3, 352-358, 2012.

(要約): ONO-1301, a synthetic prostacyclin agonist with thromboxane synthase inhibitory activity, promotes the production of hepatocyte growth factor (HGF) and vascular endothelial growth factor (VEGF) by various cell types. Here, we evaluated the therapeutic efficacy of ONO-1301 in rats with ischemia/reperfusion injury. Ligation of the left anterior descending arteries was performed in 10-week-old Wistar rats, and released 30 min later. A slow-release form of ONO-1301 was administered subcutaneously at 3h and 3 weeks after reperfusion injury. Hemodynamic parameters were significantly improved in the ONO-1301 group. Histological analysis revealed that ONO-1301 suppressed ischemic and fibrotic changes in the myocardium (ischemic area, control group: 58.6 ± 8.7% vs. ONO-1301 group: 44.4 ± 5.8%, fibrotic area, 33.5 ± 5.9% vs. 22.3 ± 6.2%, P<0.05, respectively), and enhanced neovascularization in the border zone. HGF expression was up-regulated by ONO-1301. Double-immunostaining revealed that myofibroblasts in the border zone of ischemic myocardium mainly expressed HGF. Our findings suggest that ONO-1301 might have therapeutic potential in treating ischemic heart disease.
(キーワード): Animals / Delayed-Action Preparations / Enzyme Inhibitors / Epoprostenol / Fibrosis / Heart / Hepatocyte Growth Factor / Male / Myocardium / Neovascularization, Physiologic / Pyridines / Rats / Rats, Wistar / Reperfusion Injury / Thromboxane-A Synthase
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.ejphar.2011.10.038
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22094066; ● Search Scopus @ Elsevier (PMID): 22094066; ● Search Scopus @ Elsevier (DOI): 10.1016/j.ejphar.2011.10.038

(DOI: 10.1016/j.ejphar.2011.10.038, PubMed: 22094066) Koji Yamaguchi, Tetsuzo Wakatsuki, Toshiyuki Niki, Kenya Kusunose, Kunihiko Koshiba, Shusuke Yagi, Yoshio Taketani, Takashi Iwase, Noriko Tomita, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Local persistent hypercoagulability after sirolimus-eluting stent implantation in patients with stable angina.,
International Journal of Cardiology, Vol.153, No.3, 272-276, 2011.

(要約): Late stent thrombosis (LST) after sirolimus-eluting stent (SES) implantation has been demonstrated previously. Although incomplete neointimal coverage after SES implantation has been reported, local long-term hypercoagulability remains unknown. We evaluated the local persistent coagulative response in eighty-three consecutive patients with stable angina, treated with either SES (n=51) or BMS (n=32) implantation for isolated de novo left anterior descending (LAD) stenosis. We measured prothrombin fragment F1+2 (frF1+2) and D-dimer levels sampled in the coronary sinus (CS) and sinus of Valsalva (V). The transcardiac gradient (Δ) was defined as the CS level minus V level. The ΔfrF1 + 2 and ΔD-dimer were significantly greater in the SES group than in the BMS group (0.50 ± 0.35 vs -0.14 ± 0.15 nmol/l, p=0.009 and 0.24 ± 0.21 vs -0.05 ± 0.16 μg/ml, p=0.041, respectively). We selected the hypocoagulative [ΔfrF1 + 2<0.15 (mean value-SD) nmol/l, n=21] and hypercoagulative [ΔfrF1 + 2>0.85 (mean value+SD) nmol/l, n=14] groups out of the SES patients. Multivariate analysis was performed to identify independent predictors of local hypercoagulability. Total SES length was the only independent predictor of local hypercoagulability. There was a significant positive correlation between the ΔfrF1 + 2 and total stent length in the SES group (r=0.57, p<0.05). An increased local coagulative response was observed in the convalescent phase after SES implantation as compared to BMS. Careful long-term follow-up of patients after longer SES implantation is recommended in order to avoid LST.
(キーワード): Aged / Angina, Stable / Cohort Studies / Coronary Thrombosis / Drug-Eluting Stents / Female / Humans / Male / Middle Aged / Sirolimus / Thrombophilia / Time Factors
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.ijcard.2010.08.014
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20826025; ● Search Scopus @ Elsevier (PMID): 20826025; ● Search Scopus @ Elsevier (DOI): 10.1016/j.ijcard.2010.08.014

(DOI: 10.1016/j.ijcard.2010.08.014, PubMed: 20826025) Hiromu Yamazaki, Koji Yamaguchi, Takashi Iwase, Toshiyuki Niki, Kenya Kusunose, Noriko Tomita, Yoshio Taketani, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Yutaka Fukunaga, Hideki Nakanishi, Haruhiko Maruyama, Hiroyuki Matsuoka and Masataka Sata :
A patient who developed toe necrosis due to poor blood circulation after an interdigital tick bite.,
Journal of Cardiology Cases, Vol.4, No.2, e106-e109, 2011.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jccase.2011.06.005
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1016/j.jccase.2011.06.005

(DOI: 10.1016/j.jccase.2011.06.005) Takeshi Soeki, Toshiyuki Niki, Kenya Kusunose, Sachiko Bando, Yoichiro Hirata, Noriko Tomita, Koji Yamaguchi, Kunihiko Koshiba, Shusuke Yagi, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Elevated concentrations of pentraxin 3 are associated with coronary plaque vulnerability.,
Journal of Cardiology, Vol.58, No.2, 151-157, 2011.

(要約): Inflammation is a critical contributing factor to the development and progression of atherosclerosis. Pentraxin 3 (PTX3) is produced abundantly in atherosclerotic lesions while C-reactive protein (CRP) is mainly produced in the liver. In this study, we investigated whether plasma levels of PTX3 might be a sensitive marker both for the severity of coronary artery disease and vulnerable plaques. Next, we determined whether assays for inflammatory molecules can be used to monitor the therapeutic effects of telmisartan on stabilization of vulnerable atherosclerotic plaques. We measured PTX3 concentrations in the peripheral and coronary sinus plasma of 40 patients with angina pectoris (AP) and 20 control subjects. Next, in 28 patients with AP, we determined the correlation between levels of inflammatory molecules and the computed tomography (CT) density of plaques as a quantitative index of plaque vulnerability. There was no significant difference in peripheral plasma PTX3 concentrations between patients with AP and control subjects, while coronary sinus plasma PTX3 concentrations were significantly higher in AP patients than control subjects. The concentrations of PTX3 in coronary sinus and peripheral plasma correlated with Gensini scores as an index of severity of coronary atherosclerosis. Interestingly, there was a significantly negative correlation between plasma PTX3 concentrations and CT density (r=-0.67, p<0.01). On the other hand, CT density did not correlate with the peripheral plasma concentrations of monocyte chemoattractant protein-1 (MCP-1) or high-sensitivity CRP (hsCRP). Furthermore, telmisartan treatment for 6 months decreased plasma concentrations of PTX3 but not those of MCP-1 or hsCRP in 12 patients with essential hypertension. Multivariate regression analysis revealed that changes in PTX3 levels were independent of blood pressure changes. PTX3 is likely more specific than hsCRP as an indicator of coronary plaque vulnerability that could lead to plaque rupture.
(キーワード): Aged / Angina Pectoris / Angiotensin II Type 1 Receptor Blockers / Benzimidazoles / Benzoates / Biological Markers / C-Reactive Protein / Coronary Artery Disease / Coronary Sinus / Disease Progression / Drug Monitoring / Female / Humans / Inflammation Mediators / Male / Middle Aged / Plaque, Atherosclerotic / Serum Amyloid P-Component / Severity of Illness Index / Tomography, Spiral Computed
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jjcc.2011.04.005
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21676590; ● Search Scopus @ Elsevier (PMID): 21676590; ● Search Scopus @ Elsevier (DOI): 10.1016/j.jjcc.2011.04.005

(DOI: 10.1016/j.jjcc.2011.04.005, PubMed: 21676590) Toshiyuki Niki, Tetsuzo Wakatsuki, Koji Yamaguchi, Kenya Kusunose, Kunihiko Koshiba, Shusuke Yagi, Yoshio Taketani, Takashi Iwase, Noriko Tomita, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Comparison of chronic-stage histopathological findings among 3 coronary stents implanted in the same patient.,
International Journal of Cardiology, Vol.150, No.1, e25-e27, 2011.

(要約): A 73-year-old woman suffering from anterior thoracic pain on exertion presented to our hospital. We performed coronary angiography and noted three stenotic legions in each coronary artery. For each angiographic finding, we implanted a bare metal stent (BMS), sirolimus-eluting stent (SES) and paclitaxel-eluting stent (PES) into the right coronary artery, left anterior descending and left circumflex coronary arteries, respectively. Nine months later, she died of lung disease, and we could compare the histopathological findings among the three coronary stents. In the drug-eluting stents, very thin intima, infiltration of inflammatory cells, and fibrin deposition were observed, while thick intima and no inflammatory findings were observed in the BMS. Fibrin deposition was more marked in the PES than in the SES. This report shows marked differences in the subsequent pathological course among three stents in the same patient.
(キーワード): Aged / Coronary Stenosis / Drug-Eluting Stents / Female / Humans / Paclitaxel / Sirolimus / Stents
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.ijcard.2009.08.032
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19735952; ● Search Scopus @ Elsevier (PMID): 19735952; ● Search Scopus @ Elsevier (DOI): 10.1016/j.ijcard.2009.08.032

(DOI: 10.1016/j.ijcard.2009.08.032, PubMed: 19735952) M Bando, Takeshi Soeki, Toshiyuki Niki, Kenya Kusunose, N Tomita, Koji Yamaguchi, Kunihiko Koshiba, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Ventricular tachycardia in cardiac sarcoidosis controlled by radiofrequency catheter ablation.,
Internal Medicine, Vol.50, No.11, 1201-1206, 2011.

(要約): We report a case of a 78-year-old woman with cardiac sarcoidosis with a history of syncope and palpitation. Further assessment with echocardiography, gadolinium-enhanced cardiovascular magnetic resonance (CMR) and histology led to a diagnosis of cardiac sarcoidosis. As the patient suffered from ventricular tachycardia (VT) despite active corticosteroid therapy, an implantable cardioverter-defibrillator (ICD) was positioned. She was also administered a beta blocker, but an electrical storm appeared every several days requiring ICD therapy. The drug-refractory VT was finally controlled with a catheter ablation session, during which we could detect the VT focus in the right ventricular outflow tract next to the aneurysm by using an electroanatomic mapping system (CARTO). Referring to echocardiographic and CMR images proved very useful in detecting the aneurysm using the CARTO system.
(キーワード): Adrenergic beta-Antagonists / Aged / Catheter Ablation / Comorbidity / Defibrillators, Implantable / Female / Humans / Magnetic Resonance Imaging / Sarcoidosis / Tachycardia, Ventricular / Treatment Failure / Treatment Outcome
(出版サイトへのリンク): ● Publication site (DOI): 10.2169/internalmedicine.50.4580
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21628935; ● Search Scopus @ Elsevier (PMID): 21628935; ● Search Scopus @ Elsevier (DOI): 10.2169/internalmedicine.50.4580

(DOI: 10.2169/internalmedicine.50.4580, PubMed: 21628935) Kenya Kusunose, Hirotsugu Yamada, Noriko Tomita, Susumu Nishio, Toshiyuki Niki, Koji Yamaguchi, Kunihiko Koshiba, Shusuke Yagi, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Serial imaging changes during treatment of Takayasu arteritis with pulmonary artery stenosis.,
International Journal of Cardiology, Vol.148, No.3, 47-50, 2011.

(要約): Most cases of chronic stenosis or occlusive lesions of the pulmonary arteries are attributed to thromboembolism, and pulmonary arteritis is extremely rare as the primary cause of these entities. We report a case of pulmonary stenosis and occlusion caused by Takayasu arteritis. The patient was a 54-year-old woman who presented with dyspnea. Total occlusion of the left pulmonary artery and significant stenosis of the right pulmonary artery caused by Takayasu arteritis were confirmed by various imaging modalities including pulmonary angiography, (18)fluorodeoxyglucose-positron emission tomography, magnetic resonance imaging and real-time three-dimensional transesophageal echocardiography. After 6 weeks of steroid therapy, follow-up imaging studies showed that the stenotic lesion had resolved.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.ijcard.2009.02.036
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19299026; ● Search Scopus @ Elsevier (PMID): 19299026; ● Search Scopus @ Elsevier (DOI): 10.1016/j.ijcard.2009.02.036

(DOI: 10.1016/j.ijcard.2009.02.036, PubMed: 19299026) Shusuke Yagi, Masashi Akaike, Takashi Iwase, Kenya Kusunose, Toshiyuki Niki, Koji Yamaguchi, Kunihiko Koshiba, Yoshio Taketani, Noriko Tomita, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Acute hemodynamic effects of adaptive servo ventilation in patients with pulmonary hypertension.,
International Journal of Cardiology, Vol.148, No.1, 125-127, 2011.

(キーワード): Aged / Aged, 80 and over / Female / Hemodynamics / Humans / Hypertension, Pulmonary / Intermittent Positive-Pressure Ventilation / Male / Middle Aged / Time Factors
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.ijcard.2011.01.074
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21334081; ● Search Scopus @ Elsevier (PMID): 21334081; ● Search Scopus @ Elsevier (DOI): 10.1016/j.ijcard.2011.01.074

(DOI: 10.1016/j.ijcard.2011.01.074, PubMed: 21334081) Yoichiro Hirata, Takeshi Soeki, Hirotsugu Yamada, Asuka Shiota, Michio Shimabukuro, Yoshiki Sakai, Mizuho Nakayama, Kunio Matsumoto, Takashi Igarashi and Masataka Sata :
A synthetic prostacycline agonist, ONO-1301, ameliorates ventricular remodeling after acute myocardial infarction via up-regulation of HGF in rat.,
Biomedicine & Aging Pathology, Vol.1, No.2, 90-96, 2011.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.biomag.2011.06.004
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1016/j.biomag.2011.06.004

(DOI: 10.1016/j.biomag.2011.06.004) Shusuke Yagi, Masashi Akaike, Ken-ichi Aihara, Takashi Iwase, Kazue Ishikawa, Sumiko Yoshida, Yuka Sumitomo-Ueda, Kenya Kusunose, Toshiyuki Niki, Koji Yamaguchi, Kunihiko Koshiba, Yoshio Taketani, Noriko Tomita, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Toshio Matsumoto and Masataka Sata :
Effect of low-dose (1 mg/day) pitavastatin on left ventricular diastolic function and albuminuria in patients with hyperlipidemia.,
The American Journal of Cardiology, Vol.107, No.11, 1644-1649, 2011.

(要約): The aim of the present study was to evaluate the factors that modulate the protective action of statins on cardiorenal function, regardless of the lipid-lowering effect. To treat abnormal serum lipid profiles, low-dose pitavastatin (1.0 mg/day) was administered to 65 hyperlipidemic patients. The exclusion criteria included left ventricular ejection fraction <40% and apparent renal disease. Age- and gender-matched patients with hyperlipidemia (n = 40) served as the controls. After 12 to 16 weeks of pitavastatin treatment, pitavastatin had decreased low-density lipoprotein cholesterol (from 143.5 ± 31.4 to 98.2 ± 19.4 mg/dl, p <0.01), triglycerides (from 157.7 ± 57.2 to 140.5 ± 60.7 mg/dl, p <0.01), E/e' (from 10.8 ± 6.2 to 9.0 ± 4.5, p <0.05), a parameter of left ventricular diastolic function, and albuminuria (from 47.6 ± 55.9 to 28.5 ± 40.0 mg/g creatinine, p <0.01). Furthermore, pitavastatin decreased serum transforming growth factor-1 (from 709 ± 242 to 550 ± 299 pg/ml, p <0.01), urinary 8-hydroxy-2'-deoxyguanosine (from 6.6 ± 4.1 to 5.0 ± 3.1 g/g creatinine, p <0.01), an oxidative stress marker, and increased urinary nitrate and nitrite (from 22.5 ± 14.6 to 29.4 ± 27.6 nmol/g creatinine, p <0.05). No such changes were observed in the controls. Multiple regression analysis in the pitavastatin group revealed the effect of pitavastatin on cardiorenal function was associated with suppression of oxidative stress, but not on low-density lipoprotein cholesterol reduction. In conclusion, pitavastatin decreases E/e' and albuminuria, which is associated with suppression of oxidative stress.
(キーワード): Aged / Albuminuria / Case-Control Studies / Cholesterol, LDL / Diastole / Female / Humans / Hydroxymethylglutaryl-CoA Reductase Inhibitors / Hyperlipidemias / Male / Middle Aged / Quinolines / Treatment Outcome / Triglycerides / Ventricular Function, Left
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.amjcard.2011.01.054
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21458773; ● Search Scopus @ Elsevier (PMID): 21458773; ● Search Scopus @ Elsevier (DOI): 10.1016/j.amjcard.2011.01.054

(DOI: 10.1016/j.amjcard.2011.01.054, PubMed: 21458773) 長井幸二郎, 楠瀬賢也, 西尾進, 竹谷善雄, 山田博胤, 佐田政隆, 近藤直樹, 岸史, 岸誠司, 荒岡利和, 松浦元一, 美馬晶, 安部秀斉, 村上太一, 中村雅将, 土井俊夫 :
片腎の高齢者腎機能障害患者において超音波検査で腎動脈狭窄症を指摘され，経皮的腎血管拡張術で高血圧，腎機能の著明な改善がみられた1例,
日本腎臓学会誌, Vol.53, No.1, 68-74, 2011年.

(要約): Arteriosclerotic renal artery stenosis is one of the increasingly common diseases that affects many aged patients. There are various non-invasive methods to diagnose renal artery stenosis, such as contrast enhanced CT or MRI. However, these methods are not appropriate for patients with renal dysfunction. Ultrasound sonography is becoming one of the promising methods to diagnose artery stenosis because of photographic improvements. In this case, a 72-year-old woman was hospitalized 7 months after nephrectomy because of severe hypertension, heart failure and kidney dysfunction. The heart failure was quite uncontrollable in spite of massive administration of diuretics, and finally, hemodialysis was started to control her volume status. In consideration of her past history and abdominal bruit, we evaluated the renal artery stenosis by ultrasound sonography and confirmed the diagnosis by renal angiography. To improve hypertension control, we performed renal artery stenting, which resulted in an impressive improvement of her blood pressure and renal function. We recognized the importance of careful causal evaluation of renal dysfunction, even though it is difficult to apply invasive therapy to patients after nephrectomy.
(キーワード): Aged / Female / Heart Failure / Humans / Hypertension / Nephrectomy / Renal Artery Obstruction / Renal Insufficiency / Stents / Treatment Outcome
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21370580; ● CiNii @ 国立情報学研究所 (CRID): 1520009407114348800; ● Search Scopus @ Elsevier (PMID): 21370580

(PubMed: 21370580, CiNii: 1520009407114348800) Koji Yamaguchi, Tetsuzo Wakatsuki, Toshiyuki Niki, Yoshio Taketani, H. Oezuka, Kenya Kusunose, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Observation of short-term atorvastatin-induced changes in coronary arterial plaque properties using integrated backscatter intravascular ultrasound in a patient.,
Journal of Cardiology Cases, Vol.3, No.3, e111-e114, 2011.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jccase.2011.03.007
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1016/j.jccase.2011.03.007

(DOI: 10.1016/j.jccase.2011.03.007) Kenya Kusunose, Hirotsugu Yamada, Susumu Nishio, Yukio Mizuguchi, Masahito Choraku, Yasuhiro Maeda, Shinobu Hosokawa, Nobuo Yamazaki, Noriko Tomita, Toshiyuki Niki, Koji Yamaguchi, Kunihiko Koshiba, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Validation of longitudinal peak systolic strain by speckle tracking echocardiography with visual assessment and myocardial perfusion SPECT in patients with regional asynergy.,
Circulation Journal, Vol.75, No.1, 141-147, 2011.

(要約): Automated function imaging (AFI) is a recently developed method of calculating the longitudinal peak systolic strains (LS) of the regional left ventricular (LV) wall using speckle tracking echocardiography and displaying them on a single bull's-eye map. The feasibility of AFI in patients with regional LV wall motion abnormalities caused by myocardial infarction (MI) was evaluated by comparison with visual assessment and myocardial perfusion single-photon emission computed tomography (SPECT). Segmental LS was measured by AFI in 60 patients with MI (67 ± 11 years) and 58 controls (71 ± 9 years). Wall thickening (WT) was measured by SPECT in 20 patients with MI. There was a strong positive linear relationship between the wall motion score index by expert visual assessment and global LS. The receiver-operating characteristic analysis revealed the best cutoff value of 11% < LS to identify hypokinetic segments. The overall accuracy of wall motion scoring by LS in the 2,006 segments was 96.8% (κ = 0.90) compared with visual assessment. The correlation coefficient between LS and WT was R² = 0.65 in the 340 segments. Assessment of LV regional asynergy by AFI showed good agreement with visual and SPECT assessments. AFI is clinically useful for quantitative assessment of LV regional wall motion abnormalities.
(キーワード): Aged / Aged, 80 and over / Algorithms / Case-Control Studies / Echocardiography, Doppler / Feasibility Studies / Humans / Image Interpretation, Computer-Assisted / 日本 (Japan) / Middle Aged / Myocardial Contraction / Myocardial Infarction / Myocardial Perfusion Imaging / Observer Variation / Predictive Value of Tests / Reproducibility of Results / Tomography, Emission-Computed, Single-Photon / Ventricular Dysfunction, Left / Ventricular Function, Left
(出版サイトへのリンク): ● Publication site (DOI): 10.1253/circj.CJ-10-0551
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21099120; ● Search Scopus @ Elsevier (PMID): 21099120; ● Search Scopus @ Elsevier (DOI): 10.1253/circj.CJ-10-0551

(DOI: 10.1253/circj.CJ-10-0551, PubMed: 21099120) 門田宗之, 竹谷善雄, 若槻哲三, 山口浩司, 楠瀬賢也, 仁木敏之, 坂東左知子, 久岡白陽花, 上田由佳, 冨田紀子, 竹内秀和, 岩瀬俊, 山田博胤, 添木武, 赤池雅史, 佐田政隆, 長井幸二郎, 土井俊夫 :
繰り返す心不全と維持透析導入から離脱しえた腎動脈狭窄症の一例,
四国医学雑誌, Vol.66, No.5, 6, 175-180, 2010年.

(徳島大学機関リポジトリ): ● Metadata: 110339

(徳島大学機関リポジトリ: 110339) Takayuki Ise, Ken-ichi Aihara, Yuka Ueda, Sumiko Yoshida, Yasumasa Ikeda, Shusuke Yagi, Takashi Iwase, Hirotsugu Yamada, Masashi Akaike, Masataka Sata and Toshio Matsumoto :
Plasma heparin cofactor II activity is inversely associated with left atrial volume and diastolic dysfunction in humans with cardiovascular risk factors.,
Hypertension Research, Vol.34, No.2, 225-231, 2010.

(要約): Thrombin has a crucial role in cardiac remodeling through protease-activated receptor-1 activation in cardiac fibroblasts and cardiomyocytes. As heparin cofactor II (HCII) inhibits the action of tissue thrombin in the cardiovascular system, it is possible that HCII counteracts the development of cardiac remodeling. We investigated the relationships between plasma HCII activity and surrogate markers of cardiac geometry, including left atrial volume index (LAVI), relative wall thickness (RWT) and left ventricular mass index, and deceleration time (DcT) and the ratio of peak E velocity to early diastolic mitral annulus velocity (E/e' ratio) as surrogate markers of left ventricular diastolic dysfunction measured using echocardiography in 304 Japanese elderly individuals without systolic heart failure (169 men and 135 women; mean age: 65.4 ± 11.8 years). Mean plasma HCII activity in all participants was 95.8 ± 17.0% and there was no difference between the mean plasma HCII activities in males and females. Multiple regression analysis revealed that there were significant inverse relationships between plasma HCII activity and LAVI (coefficient: -0.2302, P<0.001), between HCII activity and RWT (coefficient: -0.0007, P<0.05), between HCII activity and DcT (coefficient: -0.5189, P<0.05) and between HCII activity and E/e' ratio (coefficient: -0.0558, P<0.01). Plasma HCII activity was independently and inversely associated with the development of cardiac remodeling, including cardiac concentric change, left atrial enlargement and left ventricular diastolic dysfunction. These findings suggest that cardiac tissue thrombin inactivation by HCII is a novel therapeutic target for cardiac remodeling and atherosclerosis.
(キーワード): Aged / Cross-Sectional Studies / Female / Heparin Cofactor II / Humans / Male / Middle Aged / Risk Factors / Ventricular Dysfunction / Ventricular Remodeling
(出版サイトへのリンク): ● Publication site (DOI): 10.1038/hr.2010.211
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21107326; ● Search Scopus @ Elsevier (PMID): 21107326; ● Search Scopus @ Elsevier (DOI): 10.1038/hr.2010.211

(DOI: 10.1038/hr.2010.211, PubMed: 21107326) Shusuke Yagi, Masashi Akaike, Takashi Iwase, Kenya Kusunose, Toshiyuki Niki, Koji Yamaguchi, Kunihiko Koshiba, Sumiko Yoshida, Yuka Sumitomo-Ueda, Ken-ichi Aihara, Yoichiro Hirata, Munkhbaatar Dagvasumberel, Yoshio Taketani, Noriko Tomita, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Toshio Matsumoto and Masataka Sata :
Bosentan ameliorated exercise-induced pulmonary arterial hypertension complicated with systemic sclerosis.,
Internal Medicine, Vol.49, No.21, 2309-2312, 2010.

(要約): Pulmonary arterial hypertension (PAH) is a frequent complication in patients with systemic sclerosis. Bosentan is used in patients with symptomatic PAH; however, it has not been established whether or not bosentan ameliorates the progression of PAH in patients with no PAH-related symptoms. We present a case of systemic sclerosis with no PAH-related symptoms in which bosentan ameliorated exercise-induced PAH evaluated by 6-minute walk stress echocardiography, brachial flow-mediated dilation, and skin temperature of hands and feet. The results suggest that administration of bosentan in patients with early-stage PAH ameliorates pulmonary arterial vasodilatation through improvement of endothelial function.
(キーワード): Exercise / Exercise Test / Female / Humans / Hypertension, Pulmonary / Middle Aged / Scleroderma, Systemic / Sulfonamides
(出版サイトへのリンク): ● Publication site (DOI): 10.2169/internalmedicine.49.3812
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21048365; ● CiNii @ 国立情報学研究所 (CRID): 1390282679847104768; ● Search Scopus @ Elsevier (PMID): 21048365; ● Search Scopus @ Elsevier (DOI): 10.2169/internalmedicine.49.3812

(DOI: 10.2169/internalmedicine.49.3812, PubMed: 21048365, CiNii: 1390282679847104768) Hai-Yan Pan, Hirotsugu Yamada, Junji Chida, Siye Wang, Mihiro Yano, Min Yao, Jianhua Zhu and Hiroshi Kido :
Up-regulation of ectopic trypsins in the myocardium by influenza A virus infection triggers acute myocarditis,
Cardiovascular Research, Vol.89, No.3, 595-603, 2010.

(要約): Influenza A virus (IAV) infection markedly up-regulates ectopic trypsins in various organs, viral envelope glycoprotein processing proteases, which are pre-requisites for virus entry and multiplication. We investigated the pathological roles of trypsin up-regulation in the progression of IAV-induced myocarditis, cytokine induction, and viral replication in the hearts, and also investigated the protective effects of trypsin inhibitor on cardiac dysfunction in vivo and selective knockdown of trypsin on IAV-induced cellular damage in cardiomyoblasts. The relationship of the expression among IAV RNA, trypsins, matrix metalloproteinase (MMP)-9, MMP-2, pro-inflammatory cytokines interleukin (IL)-6, IL-1β, and tumour necrosis factor-α was analysed in mice hearts and cardiomyoblasts after IAV infection. The severity of myocarditis was most noticeable during Day 6-9 post-infection, along with peak expression of viral RNA, trypsins, particularly trypsin , MMPs, and cytokines. Cardiac ATP levels were the lowest at Day 9. Up-regulated trypsins, viral protein, and tissue-injured loci in the myocardium were closely localized. Trypsin inhibitor aprotinin treatment in vivo and selective trypsin - and trypsin -knockdown, particularly the latter, in H9c2 cardiomyoblasts significantly suppressed viral replication, up-regulation of MMPs, and production of active MMP-9 and cytokines, resulting in marked protection against cellular damage, ATP depletion, and apoptosis. IAV infection-induced cardiac dysfunction monitored by echocardiography was improved significantly by aprotinin treatment. IAV-induced trypsins, particularly trypsin , in the myocardium trigger acute viral myocarditis through stimulation of IAV replication, proMMP-9 activation, and cytokine induction. These results suggest that up-regulation of trypsins is one of the key host pathological findings in IAV-induced myocarditis.
(キーワード): Myocarditis / トリプシン (trypsin) / Influenza virus / 細胞質分裂 (cytokinesis) / Matrix metalloproteases
(出版サイトへのリンク): ● Publication site (DOI): 10.1093/cvr/cvq358
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21084314; ● Search Scopus @ Elsevier (PMID): 21084314; ● Search Scopus @ Elsevier (DOI): 10.1093/cvr/cvq358

(DOI: 10.1093/cvr/cvq358, PubMed: 21084314) Hirotsugu Yamada and Klein. L. Allan :
Diastology 2010: clinical approach to diastolic heart failure,
Journal of Echocardiography, Vol.8, No.3, 65-79, 2010.

(キーワード): Diastole / Heart failure / Echocardiography / Tissue Doppler / LV filling pressures / Prognosis
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s12574-010-0055-8
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1571980075914209792; ● Search Scopus @ Elsevier (DOI): 10.1007/s12574-010-0055-8

(DOI: 10.1007/s12574-010-0055-8, CiNii: 1571980075914209792) Sumiko Yoshida, Ken-ichi Aihara, Hiroyuki Azuma, Ryoko Uemoto, Yuka Sumitomo-Ueda, Shusuke Yagi, Yasumasa Ikeda, Takashi Iwase, Susumu Nishio, Hiromi Kawano, Junko Miki, Hirotsugu Yamada, Yoichiro Hirata, Masashi Akaike, Masataka Sata and Toshio Matsumoto :
Dehydroepiandrosterone sulfate is inversely associated with sex-dependent diverse carotid atherosclerosis regardless of endothelial function.,
Atherosclerosis, Vol.212, No.1, 310-315, 2010.

(要約): BACKGROUND: Dehydroepiandrosterone sulfate (DHEAS) is thought to be associated with life expectancy and anti-aging. However, its biological significance in atherosclerosis remains controversial. Therefore, the aim of this study was to determine whether DHEAS is associated with development of carotid atherosclerosis in subjects with cardiovascular risk factors. SUBJECTS AND METHODS: A total of 419 Japanese individuals (208 males and 211 females) were recruited from Tokushima University Hospital, Japan. In all subjects, maximum intima-media thickness (max-IMT) in all carotid arteries, and mean-IMT and mean blood flow volume (BFV) in the common carotid arteries (CCA) were measured by ultrasonography; endothelial function was assessed by flow-mediated vasodilation of the brachial artery (%FMD). Serum DHEAS and classical cardiovascular risk factors were also evaluated. Statistical significance was determined by multiple regression analysis to elucidate independent determinants of max-IMT, mean-IMT, mean CCA-BFV, and %FMD. RESULTS: Serum DHEAS levels were higher in males than in females. Multiple regression analysis revealed that DHEAS was an independent negative factor for both max-IMT and mean-IMT in males but not in females. In contrast, DHEAS was the sole positive factor for mean CCA-BFV in females but not in males. In addition, there was no significant relationship between %FMD and DHEAS regardless of sex and other confounding factors. CONCLUSION: Although DHEAS is not involved in endothelial function, DHEAS is inversely associated with sex-dependent diverse carotid atherosclerosis such as increased max-IMT and mean-IMT in males and decreased CCA-BFV in females.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.atherosclerosis.2010.05.011
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20627295; ● Search Scopus @ Elsevier (PMID): 20627295; ● Search Scopus @ Elsevier (DOI): 10.1016/j.atherosclerosis.2010.05.011

(DOI: 10.1016/j.atherosclerosis.2010.05.011, PubMed: 20627295) Kenya Kusunose, Hirotsugu Yamada, Takashi Iwase, Susumu Nishio, Noriko Tomita, Toshiyuki Niki, Koji Yamaguchi, Kunihiko Koshiba, Yoshio Taketani, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike, Shoichiro Takao, Masafumi Harada, Noriko Kagawa, Eiji Kudo and Masataka Sata :
Images in cardiovascular medicine. Cardiac magnetic resonance imaging and 2-dimensional speckle tracking echocardiography in secondary cardiac amyloidosis.,
Circulation Journal, Vol.74, No.7, 1494-1496, 2010.

(キーワード): Aged / Amyloidosis / Echocardiography / Heart Diseases / Humans / 磁気共鳴映像法 (magnetic resonance imaging) / Male / Mitral Valve / Regional Blood Flow
(出版サイトへのリンク): ● Publication site (DOI): 10.1253/circj.CJ-10-0141
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20501956; ● Search Scopus @ Elsevier (PMID): 20501956; ● Search Scopus @ Elsevier (DOI): 10.1253/circj.CJ-10-0141

(DOI: 10.1253/circj.CJ-10-0141, PubMed: 20501956) Shusuke Yagi, Masashi Akaike, Mitsunori Fujimura, Takehiko Kimura, Takeshi Nishiuchi, Takashi Iwase, Ken-ichi Aihara, Sumiko Yoshida, Yuka Sumitomo-Ueda, Kenya Kusunose, Toshiyuki Niki, Koji Yamaguchi, Kunihiko Koshiba, Yoichiro Hirata, Munkhbaatar Dagvasumberel, Yoshio Taketani, Noriko Tomita, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Toshio Matsumoto and Masataka Sata :
Congenital ventricular aneurysm as an unexpected complication of monomorphic premature ventricular contractions.,
Internal Medicine, Vol.49, No.10, 907-912, 2010.

(要約): Congenital ventricular diverticulum (CVD) in adults is a rare cardiac malformation, which includes fibrous type congenital ventricular aneurysm (CVA). CVA is often clinically asymptomatic and shows no abnormality in the electrocardiogram or chest X-ray. However, some cases of sudden death resulting from ventricular tachycardia, cardiac embolism or ventricular rupture have been reported. Therefore, physicians should perform further cardiac imaging studies to detect a CVA if ventricular arrhythmia originating from the left ventricle is observed. Here, we report two successfully followed cases of CVA which were diagnosed from premature ventricular contractions.
(キーワード): congenital ventricular aneurysm / congenital ventricular diverticulum / ventricular arrythmia
(出版サイトへのリンク): ● Publication site (DOI): 10.2169/internalmedicine.49.3008
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20467175; ● CiNii @ 国立情報学研究所 (CRID): 1390001204871212928; ● Search Scopus @ Elsevier (PMID): 20467175; ● Search Scopus @ Elsevier (DOI): 10.2169/internalmedicine.49.3008

(DOI: 10.2169/internalmedicine.49.3008, PubMed: 20467175, CiNii: 1390001204871212928) Hirotsugu Yamada, Yuichiro Mishiro, Kenya Kusunose and Masataka Sata :
Effects of additional administration of low-dose indapamide on patients with hypertension treated with angiotensin II receptor blocker.,
Journal of Cardiovascular Pharmacology and Therapeutics, Vol.15, No.2, 145-150, 2010.

(要約): BACKGROUND: Low-dose thiazide or thiazide-like diuretics have proven useful for the management of blood pressure in patients older than 65 years (elderly group). However, there are few reports about the antihypertensive effects of antihypertensive diuretic agents in patients younger than 65 years (middle-aged group). So, we evaluated the efficacy of low-dose indapamide on blood pressure. METHODS: Indapamide(1 mg) was given daily for 3 months and was then given every other day for 3 months to patients whose hypertension was poorly controlled with angiotensin II receptor blocker (ARB)-based treatment. RESULTS: After daily administration of indapamide, blood pressure was significantly decreased in both the middle-aged and elderly groups. Blood pressure was not significantly changed by every-other-day administration compared with that observed after daily administration in either group. The rate of attainment of the target blood pressure was 90.3% and 85.7% in the middle-aged and elderly groups, respectively. The serum uric acid levels were reduced after every-other-day administration compared to daily administration but tended to be higher than the levels at the baseline in both groups. CONCLUSIONS: The addition of low-dose indapamide is a useful strategy for the management of hypertension, as it reduced blood pressure without marked side effects.
(出版サイトへのリンク): ● Publication site (DOI): 10.1177/1074248410361336
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20200326; ● Search Scopus @ Elsevier (PMID): 20200326; ● Search Scopus @ Elsevier (DOI): 10.1177/1074248410361336

(DOI: 10.1177/1074248410361336, PubMed: 20200326) Shusuke Yagi, Masashi Akaike, Ken-ichi Aihara, Takashi Iwase, Kazue Ishikawa, Sumiko Yoshida, Yuka Sumitomo-Ueda, Kenya Kusunose, Toshiyuki Niki, Koji Yamaguchi, Kunihiko Koshiba, Yoichiro Hirata, Munkhbaatar Dagvasumberel, Yoshio Taketani, Noriko Tomita, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Toshio Matsumoto and Masataka Sata :
Ezetimibe ameliorates metabolic disorders and microalbuminuria in patients with hypercholesterolemia.,
Journal of Atherosclerosis and Thrombosis, Vol.17, No.2, 173-180, 2010.

(要約): AIM: Ezetimibe, an inhibitor of Niemann-Pick C1-like 1 protein, has been shown to reduce the intestinal absorption of cholesterol. We investigated whether it also has beneficial effects on metabolic disorder and/or renal insufficiency in patients with hypercholesterolemia. METHODS: Ezetimibe was administered to 38 Japanese patients with hypercholesterolemia to obtain appropriate low-density lipoprotein cholesterol (LDL-chol) levels. Age- and sex-matched patients with hypercholesterolemia (n=38) were the controls. We evaluated the effects of ezetimibe before and 4 to 8 weeks after ezetimibe treatment. RESULTS: Ezetimibe significantly decreased LDL-chol levels and metabolic syndrome-related factors, including body weight, waist circumference, blood pressure; homeostasis model assessment insulin resistance (HOMA-IR), and urinary albumin excretion, were significantly reduced. In addition, it decreased the level of high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor (TNF)-alpha, the urinary excretion of 8-hydroxy-2'-deoxyguanosine, a parameter of oxidative stress, and increased the urinary excretion of nitrate and nitrite (NOx). In the controls we observed no such changes. Excepting the decrease in the serum TNF-alpha level, the effects of ezetimibe were not correlated with decreased LDL-chol levels. CONCLUSION: Ezetimibe ameliorated the status of metabolic syndrome and microalbuminuria, reduced inflammation and oxidative stress, and increased nitric oxide bioavailability in a LDL-chol reduction-dependent and -independent manner.
(キーワード): Aged / Albuminuria / Anticholesteremic Agents / Azetidines / C-Reactive Protein / Case-Control Studies / Cholesterol, LDL / Deoxyguanosine / Female / Humans / Hypercholesterolemia / Male / Metabolic Diseases / Metabolic Syndrome X / Middle Aged / Nitrates / Nitrites / Oxidative Stress / Tumor Necrosis Factor-alpha
(出版サイトへのリンク): ● Publication site (DOI): 10.5551/jat.2378
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20150722; ● Search Scopus @ Elsevier (PMID): 20150722; ● Search Scopus @ Elsevier (DOI): 10.5551/jat.2378

(DOI: 10.5551/jat.2378, PubMed: 20150722) Takashi Iwase, Shoichiro Takao, Masashi Akaike, K Adachi, Y Sumitomo-Ueda, Shusuke Yagi, T Niki, Kenya Kusunose, N Tomita, Y Hirata, Koji Yamaguchi, Kunihiko Koshiba, Yoshio Taketani, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, KI Aihara, Masafumi Harada, H Nishitani and Masataka Sata :
Diagnostic utility of cardiac magnetic resonance for detection of cardiac involvement in female carriers of Duchenne muscular dystrophy.,
Heart Asia, Vol.2, 52-55, 2010.

(出版サイトへのリンク): ● Publication site (DOI): 10.1136/ha.2010.002006
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27325943; ● Search Scopus @ Elsevier (PMID): 27325943; ● Search Scopus @ Elsevier (DOI): 10.1136/ha.2010.002006

(DOI: 10.1136/ha.2010.002006, PubMed: 27325943) Kenya Kusunose, Hirotsugu Yamada, S Nishio, N Tomita, T Niki, K Yamaguchi, Kunihiko Koshiba, Shusuke Yagi, Y Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Clinical Utility of Single Beat E/e' Obtained by Simultaneous Recording of Flow and Tissue Doppler Velocities in Atrial Fibrillation with Preserved Systolic Function.,
JACC. Cardiovascular Imaging, Vol.2, No.10, 1147-1156, 2009.

(要約): We evaluated the usefulness of the ratio of the early diastolic transmitral flow velocity (E) to the mitral annular velocity (e') calculated from simultaneously recorded E and e' in atrial fibrillation (AF). The ratio of the E to the e' (E/e') has been reported as a useful index even in AF patients. However, E and e' were measured during different beats in the previous studies. Fifty-six AF patients with preserved systolic function (mean age 66 +/- 11 years) underwent routine echocardiographic study. The E/e' was calculated from the E and e' simultaneously recorded by the dual Doppler echocardiography. A single-beat E/e' was calculated from simultaneously recorded E and e' when the preceding RR interval/pre-preceding RR interval = 1. Brain natriuretic peptide (BNP) levels were also examined. Twenty-one patients underwent simultaneous pulmonary artery catheterization. The single-beat lateral E/e' correlated with pulmonary capillary wedge pressure (PCWP) (r = 0.74, p < 0.001). The single-beat lateral E/e' of >or=11 could predict elevated PCWP (>or=15 mm Hg) with a sensitivity of 90% and a specificity of 90%. The single-beat lateral E/e' also correlated well with the log BNP concentration. The single-beat lateral E/e' of >or=9.2 predicted a plasma BNP level of >or=200 pg/ml with 88% sensitivity and 84% specificity. The single-beat lateral E/e' correlated with plasma BNP level and PCWP in AF patients with preserved systolic function. In addition, the single-beat lateral E/e' (>or=11) was a good predictor of elevated PCWP (>or=15 mm Hg). Dual Doppler echocardiography offers an advantage of providing the single-beat lateral E/e' correctly even in AF patients, for the evaluation of left ventricular diastolic function.
(キーワード): Adult / Aged / Aged, 80 and over / Atrial Fibrillation / Biological Markers / Catheterization, Swan-Ganz / Coronary Circulation / Diastole / Echocardiography, Doppler, Color / Echocardiography, Doppler, Pulsed / Female / Heart Rate / Humans / Linear Models / Male / Middle Aged / Mitral Valve / Natriuretic Peptide, Brain / Predictive Value of Tests / Pulmonary Wedge Pressure / Sensitivity and Specificity / Systole / Ventricular Function, Left
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jcmg.2009.05.013
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19833302; ● Search Scopus @ Elsevier (PMID): 19833302; ● Search Scopus @ Elsevier (DOI): 10.1016/j.jcmg.2009.05.013

(DOI: 10.1016/j.jcmg.2009.05.013, PubMed: 19833302) Kenya Kusunose, Hirotsugu Yamada, Takashi Todoroki, Susumu Nishio, Toshiyuki Niki, Koji Yamaguchi, Kunihiko Koshiba, Shusuke Yagi, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike, Tetsuya Kitagawa and Masataka Sata :
Platypnea-orthodeoxia syndrome associated with patent foramen ovale and aortic ectasia.,
Echocardiography, Vol.26, No.1, 114-117, 2008.

(要約): A 59-year-old man was admitted for dyspnea on exertion and edema. The patient did not have any pulmonary diseases that could cause dyspnea. Transesophageal echocardiography on the tilting bed with contrast infusion revealed a right-to-left shunt through the patent foramen ovale. Therefore, he was diagosed as platypnea-orthodeoxia syndrome due to the patent foramen ovale. Surgical closure was done and all of his symptoms had improved.
(キーワード): Aortic Diseases / Dyspnea / 経食道心エコー (transesophageal echocardiography) / Edema, Cardiac / Foramen Ovale, Patent / Humans / Male / Middle Aged / 症候群 (syndrome) / Treatment Outcome
(出版サイトへのリンク): ● Publication site (DOI): 10.1111/j.1540-8175.2008.00780.x
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19017323; ● Search Scopus @ Elsevier (PMID): 19017323; ● Search Scopus @ Elsevier (DOI): 10.1111/j.1540-8175.2008.00780.x

(DOI: 10.1111/j.1540-8175.2008.00780.x, PubMed: 19017323) K Yamaguchi, Tetsuzo Wakatsuki, Kenya Kusunose, T Niki, K Koshiba, Hirotsugu Yamada, Takeshi Soeki and Masashi Akaike :
A case of neurogenic myocardial stunning presenting transient left ventricular mid-portion ballooning simulating atypical takotsubo cardiomyopathy.,
Journal of Cardiology, Vol.52, No.1, 53-58, 2008.

(要約): A 57-year-old female patient, who was initially suspected to have subarachnoid hemorrhage, was admitted to our hospital. She experienced severe dyspnea and chest pain owing to pneumonia on the fourth admission day. Electrocardiography showed ST-segment elevation in leads V(2) through V(5), and echocardiography revealed hypokinetic left ventricular wall motion. No stenosis was found in the coronary arteries by urgent coronary angiography. However, left ventriculography revealed that the basal and apical areas were hyperkinetic and the mid portion was akinetic. After a month, left ventricular wall motion was improved and coronary artery spasm provocation tests were negative. Although the clinical course of this patient was similar to that of neurogenic myocardial stunning, the shape of her left ventricle was not typical.
(キーワード): Coronary Angiography / Diagnosis, Differential / Echocardiography / Electrocardiography / Female / Humans / Middle Aged / Myocardial Stunning / Takotsubo Cardiomyopathy / Ventricular Dysfunction, Left
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jjcc.2008.03.004
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18639778; ● Search Scopus @ Elsevier (PMID): 18639778; ● Search Scopus @ Elsevier (DOI): 10.1016/j.jjcc.2008.03.004

(DOI: 10.1016/j.jjcc.2008.03.004, PubMed: 18639778) Y Notomi, ZB Popovic, Hirotsugu Yamada, DW Wallick, MG Martin, SJ Oryszak, T Shiota, NL Greenberg and JD Thomas :
Ventricular untwisting: a temporal link between left ventricular relaxation and suction.,
American Journal of Physiology, Heart and Circulatory Physiology, Vol.294, No.1, H505-513, 2008.

(要約): Left ventricular (LV) untwisting starts early during the isovolumic relaxation phase and proceeds throughout the early filling phase, releasing elastic energy stored by the preceding systolic deformation. Data relating untwisting, relaxation, and intraventricular pressure gradients (IVPG), which represent another manifestation of elastic recoil, are sparse. To understand the interaction between LV mechanics and inflow during early diastole, Doppler tissue images (DTI), catheter-derived pressures (apical and basal LV, left atrial, and aortic), and LV volume data were obtained at baseline, during varying pacing modes, and during dobutamine and esmolol infusion in seven closed-chest anesthetized dogs. LV torsion and torsional rate profiles were analyzed from DTI data sets (apical and basal short-axis images) with high temporal resolution (6.5 +/- 0.7 ms). Repeated-measures regression models showed moderately strong correlation of peak LV twisting with peak LV untwisting rate (r = 0.74), as well as correlations of peak LV untwisting rate with the time constant of LV pressure decay (tau, r = -0.66) and IVPG (r = 0.76, P < 0.0001 for all). In a multivariate analysis, peak LV untwisting rate was an independent predictor of tau and IVPG (P < 0.0001, for both). The start of LV untwisting coincided with the beginning of relaxation and preceded suction-aided filling resulting from elastic recoil. Untwisting rate may be a useful marker of diastolic function or even serve as a therapeutic target for improving diastolic function.
(キーワード): Adrenergic beta-Agonists / Adrenergic beta-Antagonists / Animals / Blood Pressure / Cardiac Pacing, Artificial / Diastole / Dobutamine / Dogs / Echocardiography, Doppler, Color / Elasticity / Heart Ventricles / Models, Cardiovascular / Myocardial Contraction / Propanolamines / Research Design / Time Factors / Torsion, Mechanical / Ventricular Function, Left / Ventricular Pressure
(出版サイトへのリンク): ● Publication site (DOI): 10.1152/ajpheart.00975.2007
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18032523; ● Search Scopus @ Elsevier (PMID): 18032523; ● Search Scopus @ Elsevier (DOI): 10.1152/ajpheart.00975.2007

(DOI: 10.1152/ajpheart.00975.2007, PubMed: 18032523) H Tanaka, Y Oishi, Y Mizuguchi, H Miyoshi, T Ishimoto, N Nagase, Hirotsugu Yamada and T Oki :
Contribution of the pericardium to left ventricular torsion and regional myocardial function in patients with total absence of the left pericardium.,
Journal of the American Society of Echocardiography, Vol.21, No.3, 268-274, 2008.

(要約): The relationship between left ventricular (LV) torsional deformation and myocardial function has recently been recognized. However, little is known about whether the pericardium affects this relationship. Our aim was to identify the contribution of the pericardium to LV torsion and regional myocardial function in the clinical setting. We examined LV torsion in basal and apical LV short-axis views, and regional LV myocardial function, such as longitudinal strain in apical 4-chamber view, and circumferential and radial strains in parasternal LV short-axis views using 2-dimensional speckle-tracking imaging method in 5 patients with congenital total absence of the left pericardium and systolic paradoxical ventricular septal motion on M-mode echocardiogram and in 10 control subjects. Diagnosis of the pericardial defect was based on chest radiograph, computed tomography, jugular phlebogram, and M-mode and 2-dimensional echocardiogram. LV torsion was defined as the net difference in LV rotation in the basal and apical planes. There was no significant difference in LV ejection fraction determined by 2-dimensional echocardiography between the pericardial defect and control groups. LV torsion was markedly decreased in the pericardial defect group compared with the control group. There were no significant differences in longitudinal, radial, and circumferential systolic strains and systolic and early diastolic strain rates in the LV walls and in longitudinal systolic strains and systolic and early diastolic strain rates in the left atrial walls between the two groups. Pericardial defects cause a lack of LV torsion while maintaining LV regional myocardial function in patients with systolic paradoxical ventricular septal motion. Therefore, pericardium plays an important role in LV torsion.
(キーワード): Echocardiography / Female / Humans / Male / Middle Aged / Pericardium / Torsion Abnormality / Ventricular Dysfunction, Left
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.echo.2007.05.035
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 17628423; ● Search Scopus @ Elsevier (PMID): 17628423; ● Search Scopus @ Elsevier (DOI): 10.1016/j.echo.2007.05.035

(DOI: 10.1016/j.echo.2007.05.035, PubMed: 17628423) Hideji Tanaka, Yoshifumi Oishi, Yukio Mizuguchi, Shigefumi Emi, Takeo Ishimoto, Norio Nagase, Tomotsugu Tabata, Hirotsugu Yamada and Takashi Oki :
Three-dimensional evaluation of dobutamine-induced changes in regional myocardial deformation in ischemic myocardium using ultrasonic strain measurements: the role of circumferential myocardial shortening.,
Journal of the American Society of Echocardiography, Vol.20, No.11, 1294-1299, 2007.

(要約): Early identification of myocardial ischemia during high-dose dobutamine stress (DOB) has important clinical implications. Myocardial strain imaging can evaluate regional myocardial contractility in the radial, longitudinal, and circumferential directions. The aim of this study was to assess precisely the differences in deterioration of myocardial deformation among the 3 directions in patients with newly developed myocardial ischemia during high-dose (40 microg/kg/min) DOB infusion. Color Doppler tissue 2-dimensional images were recorded during DOB infusion in 20 patients without myocardial ischemia and 25 patients with scintigraphically diagnosed myocardial ischemia caused by left anterior descending coronary artery stenosis. In the offline analysis, systolic radial strain (Sr), longitudinal strain (Sl), and circumferential strain (Sc) were determined in the anteroseptal and anterolateral left ventricular walls. In 20 patients without myocardial ischemia, the peak systolic strains significantly increased in all 3 directions during DOB infusion at rates between 5 and 10 microg/kg/min (Sr 50%-69%, Sl 27%-36%, Sc 29%-38%, all P < .01) with a greater rate of change in the Sr (1.8 and 1.9 times, respectively, P < .001) than in the Sl and Sc. However, the peak systolic strains decreased significantly during DOB infusion at rates between 5 and 10 microg/kg/min in all 3 directions (Sr 56%-35%, Sl 27%-13%, both P < .01; Sc 29%-7%, P < .001) with the greatest rate of change in the Sc in 25 patients with newly developed myocardial ischemia. In conclusion, circumferential myocardial shortening deteriorated to a greater extent during DOB infusion in patients with coronary artery stenosis, and its measurement is a promising tool for detecting newly developed myocardial ischemia.
(キーワード): Dobutamine / Dose-Response Relationship, Drug / Echocardiography, Three-Dimensional / Exercise Test / Female / Humans / Image Interpretation, Computer-Assisted / Male / Middle Aged / 心筋虚血 (myocardial ischemia) / Reproducibility of Results / Sensitivity and Specificity / Vasodilator Agents / Ventricular Dysfunction, Left
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.echo.2007.03.010
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 17604959; ● Search Scopus @ Elsevier (PMID): 17604959; ● Search Scopus @ Elsevier (DOI): 10.1016/j.echo.2007.03.010

(DOI: 10.1016/j.echo.2007.03.010, PubMed: 17604959) 河北直也, 藤田浩司, 三ツ井貴夫, 和泉唯信, 鈴江淳彦, 宇野昌明, 佐藤浩一, 永廣信治, 山田博胤, 森田奈緒美, 梶龍兒 :
3 Tesla T2 *強調MRIで中大脳動脈内塞栓子を呈した若年性脳塞栓症の1例,
脳卒中, Vol.29, No.3, 469-473, 2007年.

(キーワード): cerebral embolism / 3 Tesla T2^*-weighted image / patent foramen ovale / atrial septal aneurysm
(出版サイトへのリンク): ● Publication site (DOI): 10.3995/jstroke.29.469
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1573387451037736320; ● Search Scopus @ Elsevier (DOI): 10.3995/jstroke.29.469

(DOI: 10.3995/jstroke.29.469, CiNii: 1573387451037736320) E Akagawa, K Murata, N Tanaka, Hirotsugu Yamada, T Miura, H Kunichika, Y Wada, Y Hadano, T Tanaka, Y Nose, K Yasutomo, M Kono and M Matsuzaki :
Augmentation of left ventricular apical endocardial rotation with inotropic stimulation contributes to increased left ventricular torsion and radial strain in normal subjects, --- Quantitative assessment utilizing a novel automated tissue tracking technique ---,
Circulation Journal, Vol.71, No.5, 661-668, 2007.

(要約): The difference in the left ventricular (LV) torsion of the endo- and epicardium (Endo, Epi) with inotropic stimulation and its relation to radial strain (RS) remain unclear. LV basal and apical short-axis images were recorded in 13 normal subjects at rest and during dobutamine infusion (5, 10 microg x kg (-1) x min(-1)). A total of 8 points (anterior, lateral, posterior and septum in both Endo and Epi) were manually placed by 2-dimensional tissue tracking technique and the movement of these points during a cardiac cycle was tracked, after which the rotation angles and RS were calculated. LV torsion was defined as the net difference between the basal and apical rotations. In the LV apex, Endo-rotation increased (7.8+/-2.7 to 14.1+/-4.6 degrees, p<0.01), whereas Epi-rotation was unchanged, with dobutamine. The apical Endo-rotation was significantly greater than the Epi-rotation, although no difference was seen between the Endo and Epi in the LV base throughout the study. During dobutamine infusion, the LV Endo-torsion increased (9.5+/-2.8 to 19.3+/-4.8 degrees, p<0.01) and these values were greater than those for Epi. The apical RS increased with the dobutamine dose (39.0+/-9.3 to 61.9+/-15.5%, p<0.01), whereas basal RS initially increased at 5 microg x kg(-1) x min(-1), but thereafter showed no further increase at 10 microg x kg(-1) x min(-1) of dobutamine. Augmentation of LV rotation with inotropism was clearly observed in the apical Endo, thus causing increased LV endo-torsion and apical RS.
(キーワード): Adult / Algorithms / Automation / Cardiotonic Agents / Dobutamine / Echocardiography / Endocardium / Humans / Image Processing, Computer-Assisted / Magnetic Resonance Imaging / Myocardial Contraction / Reference Values / Rotation / Stress, Mechanical / Torsion Abnormality / Ventricular Function, Left
(出版サイトへのリンク): ● Publication site (DOI): 10.1253/circj.71.661
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 17456988; ● Search Scopus @ Elsevier (PMID): 17456988; ● Search Scopus @ Elsevier (DOI): 10.1253/circj.71.661

(DOI: 10.1253/circj.71.661, PubMed: 17456988) Hirotsugu Yamada, Tomotsugu Tabata, SJ Jaffer, JK Drinko, SE Jasper, MS Lauer, JD Thomas and AL Klein :
Clinical features of mixed physiology of constriction and restriction, --- Echocardiographic characteristics and clinical outcome ---,
European Journal of Echocardiography, Vol.8, No.3, 185-194, 2007.

(要約): An entity of patients with mixed physiology of constriction and restriction has been reported, however, the characteristics of these patients have not been well documented. We evaluated the clinical features and the outcome of these patients. Study subjects consisted of 38 patients (57+/-14 years, 8 females, 30 males) who were diagnosed as having mixed physiology based on transthoracic and/or transesophageal echocardiography, MRI (or CT), cardiac catheterization, endomyocardial biopsy and/or surgical findings. Prior radiation therapy was the most frequent (50%) cause of mixed physiology followed by coronary artery bypass graft without prior radiation (24%) and heart transplantation (8%). The respiratory variation of peak early diastolic transmitral flow velocity by pulsed Doppler transesophageal echocardiography was 10.7% in patients with sinus rhythm and 18.1% in patients with atrial arrhythmia. Pericardial thickening was noted adjacent to the right-sided chambers in 19 patients, left-sided chambers in 10 patients, or both in 9 patients. All-cause 5-year mortality was 40% and unrelated to age, etiology, left ventricular systolic function and therapeutic course. There was a statistically significant difference (p<0.01) between the survival rates in patients with mixed physiology and in patients with pure constriction (n=125). Due to the high mortality in this disease, discrimination of the entity from the patients with pure constriction is mandatory. Transthoracic and transesophageal echocardiography are helpful noninvasive techniques in the diagnosis and the understanding of the physiology of patients with mixed constriction and restriction.
(キーワード): Adult / Aged / Aged, 80 and over / Cardiomyopathies / Echocardiography / Echocardiography, Doppler, Pulsed / Echocardiography, Transesophageal / Female / Heart Catheterization / Humans / Male / Middle Aged / Pericarditis / Pericardium / Prospective Studies / Treatment Outcome
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.euje.2006.03.003
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 16621720; ● Search Scopus @ Elsevier (PMID): 16621720; ● Search Scopus @ Elsevier (DOI): 10.1016/j.euje.2006.03.003

(DOI: 10.1016/j.euje.2006.03.003, PubMed: 16621720) R Ramchandran, T Takezako, Y Saad, L Stull, B Fink, Hirotsugu Yamada, S Dikalov, DG Harrison, C Moravec and SS Karnik :
Angiotensinergic stimulation of vascular endothelium in mice causes hypotension, bradycardia, and attenuated angiotensin response,
Proceedings of the National Academy of Sciences of the United States of America, Vol.103, No.50, 19087-19092, 2006.

(要約): It is not clear whether endothelial cell (EC) activation by the hormone angiotensin II (Ang II) modulates contraction of vascular smooth muscle cells (VSMCs) in the vasculature and whether impairment of this regulation in vivo contributes to hypertension. Delineation of the actions of Ang II through the type 1 receptor (AT1R) on ECs in the blood vessels has been a challenging problem because of the predominance of the AT1R functions in VSMCs that lie underneath the endothelium. We have obviated this limitation by generating transgenic (TG) mice engineered to target expression of the constitutively active N111G mutant AT1R only in ECs. In these TG mice, the enhanced angiotensinergic signal in ECs without infusion of Ang II resulted in hypotension and bradycardia. The pressor response to acute infusion of Ang II was significantly reduced. Increased expression of endothelial nitric oxide synthase and production of hypotensive mediators, nitric oxide and cyclic guanosine monophosphate, cause these phenotypes. Hypotension and bradycardia observed in the TG mice could be rescued by treatment with an AT1R-selective antagonist. Our results imply that the Ang II action by means of EC-AT1R is antagonistic to vasoconstriction in general, and it may moderate the magnitude of functional response to Ang II in VSMCs. This control mechanism in vivo most likely is a determinant of altered hemodynamic regulation involved in endothelial dysfunction in hypertensive cardiovascular disease.
(キーワード): Angiotensins / Animals / Blood Pressure / Bradycardia / Endothelium, Vascular / Gene Expression / Hypotension / Mice / Mice, Transgenic / Nitric Oxide / Nitric Oxide Synthase Type III / Phenotype / Receptor, Angiotensin, Type 1 / Receptor, TIE-1
(出版サイトへのリンク): ● Publication site (DOI): 10.1073/pnas.0602715103
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 17148616; ● Search Scopus @ Elsevier (PMID): 17148616; ● Search Scopus @ Elsevier (DOI): 10.1073/pnas.0602715103

(DOI: 10.1073/pnas.0602715103, PubMed: 17148616) Yoshio Ootaki, Hirotsugu Yamada, Masao Daimon, Kenji Kamohara, B Zoran Popovic, R Wagoner David Van, Yuanna Cheng and Kiyotaka Fukamachi :
An experimental rabbit model for off-pump left ventricular reconstruction following left ventricular aneurysm,
The Heart Surgery Forum, Vol.9, No.5, E786-E791, 2006.

(要約): Cardiac electromechanical remodeling following left ventricular reconstruction (LVR) surgery is not fully understood. Further development of an animal model will facilitate investigations in this area. In the present study, we aimed to establish a novel LVR procedure without the use of cardiopulmonary bypass in a rabbit left ventricular (LV) aneurysm model. LV aneurysm was created in 6 rabbits by ligation of the distal left coronary artery. More than a month later, LVR aneurysm surgery was performed off-pump using a purse-string suture around the aneurysm. Cardiac dimensions and function were evaluated using echocardiographic techniques perioperatively and 4 weeks after LVR surgery. Six structurally normal hearts were used as controls. LVR surgery was successfully performed in all 6 rabbits. Both LV end-diastolic volume (LVEDV, 4.6 +/- 0.9 to 3.3 +/- 0.6 mL; P < .01) and LV end-systolic volume (LVESV, 2.5 +/- 0.6 to 1.5 +/- 0.2 mL, P < .01) were decreased immediately postsurgery versus presurgery, and LV ejection fraction (LVEF) was increased (44.5 +/- 5.3 to 55.6 +/- 4.8%, P < .001). For comparison, in normal rabbits (n = 6), LVEDV, LVESV and LVEF were 3.1 +/- 0.7 mL, 1.2 +/- 0.5 mL, and 64.5 +/- 8.8%, respectively. During follow-up, one rabbit died 3 weeks after surgery from an unknown cause. In the remaining 5 animals, improvements of LVEDV (3.7+/- 0.4 mL, P < .05), LVESV (1.7 +/- 0. 3 mL, P < .01), and LVEF (53.1 +/- 2.8%, P < .01) were maintained versus presurgery values for more than 4 weeks after LVR. Off-pump LVR of rabbit LV aneurysm is an effective and less invasive surgery that resulted in sustained improvement in cardiac function with no gross intraoperative or postoperative mortality. This may be a useful model for investigations of electromechanical remodeling following LVR.
(キーワード): Animals / Cardiac Surgical Procedures / Cardiopulmonary Bypass / Disease Models, Animal / Female / Heart Aneurysm / Heart Ventricles / Male / Rabbits
(出版サイトへのリンク): ● Publication site (DOI): 10.1532/HSF98.20061035
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 17099973; ● Summary page in Scopus @ Elsevier: 2-s2.0-33750561908

(DOI: 10.1532/HSF98.20061035, PubMed: 17099973, Elsevier: Scopus) Hirotsugu Yamada, ZB Popovic, DO Martin, KC Civello and DW Wallick :
The effects of altering time delays of coupled pacing during acute atrial fibrillation,
Heart Rhythm, Vol.3, No.6, 722-727, 2006.

(要約): Coupled pacing (CP), which consists of delivering a premature electrical stimulation to the heart after the effective refractory period of ventricular activation, is a novel method for controlling ventricular rate during atrial fibrillation (AF). It also has been established that CP improves pump function by enhancing external cardiac work and myocardial efficiency. The purpose of the present study was to determine if two time delays for CP (short and long) would result in similar improvements in ventricular function. In a canine model, we applied CP at two time delays (CP-S and CP-L) during two stages: sinus rhythm (SR) and acute AF. The cardiac responses to CP during SR served as the nontachycardic and nondepressed control. During both rhythms, we shortened the coupling interval until we obtained maximal contractility, designated CP-S. Next, we increased the delay until we started to see a measurable secondary contraction (left ventricular pressure development of approximately 20 mmHg). These longer delays were designated CP-L. Our results showed that the ventricular rate of intrinsic activation (VRIA) remained decreased despite prolongation of the time delay of CP during both AF and SR. Also, both delays of CP increased left ventricular systolic pressure (LVSP) and dLVP/dt, which are indices of myocardial contractility. In contrast, CP increased external cardiac work only during AF. Prolonging this time delay did not markedly decrease the improvement in external cardiac work. Myocardial O(2) consumption (MVO(2)) did not significantly change as the result of CP during either SR or AF. Finally, myocardial efficiency improved during AF as the result of CP at both time delays. In conclusion, shorter time delays for CP increased contractile strength during both SR and AF. However, extending the time delay of CP had minimal effects on diminishing the improved ventricular pump function and energetics that resulted from CP during AF. Thus, the maximal enhancement of myocardial contractility via CP-S was not needed to maintain the improved ventricular function during acute AF when CP is applied.
(キーワード): Acute Disease / Animals / Atrial Fibrillation / Cardiac Pacing, Artificial / Disease Models, Animal / Dogs / Echocardiography / Hemodynamics / Myocardial Contraction / Myocardial Infarction / Pacemaker, Artificial / Time Factors / Ventricular Function, Left / Ventricular Premature Complexes
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.hrthm.2006.02.007
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 16731478; ● Search Scopus @ Elsevier (PMID): 16731478; ● Search Scopus @ Elsevier (DOI): 10.1016/j.hrthm.2006.02.007

(DOI: 10.1016/j.hrthm.2006.02.007, PubMed: 16731478) 河野智仁, 福田大和, 渡部智紀, 山口浩司, 小柴邦彦, 山田博胤, 添木武, 若槻哲三, 伊東進, 野村昌弘 :
本態性高血圧症におけるアゼルニジピンの自律神経活動に及ぼす影響についての検討,
Therapeutic Research, Vol.27, No.2, 249-253, 2006年.

(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-34249101008

(Elsevier: Scopus) 小柴邦彦, 河野智仁, 福田大和, 渡部智紀, 山口浩司, 山田博胤, 添木武, 若槻哲三, 伊東進, 野村昌弘 :
心肥大を合併する本態性高血圧患者におけるアゼルニジピンによる抗動脈効果作用および心肥大抑制作用の検討,
Therapeutic Research, Vol.27, 115-120, 2006年.

(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-77954413525

(Elsevier: Scopus) Youhua Zhang, Hirotsugu Yamada, Steve Bibevski, Shaowei Zhuang, Kent A Mowrey, Don W Wallick, Seil Oh and Todor N Mazgalev :
Chronic atrioventricular nodal vagal stimulation, --- first evidence for long-term ventricular rate control in canine atrial fibrillation model ---,
Circulation, Vol.112, No.19, 2904-2911, 2005.

(要約): We have previously demonstrated that selective atrioventricular nodal (AVN) vagal stimulation (AVN-VS) can be used to control ventricular rate during atrial fibrillation (AF) in acute experiments. However, it is not known whether this approach could provide a long-term treatment in conscious animals. Thus, this study reports the first observations on the long-term efficacy and safety of this novel approach to control ventricular rate during AF in chronically instrumented dogs. In 18 dogs, custom-made bipolar patch electrodes were sutured to the epicardial AVN fat pad for delivery of selective AVN-VS by a subcutaneously implanted nerve stimulator (pulse width 100 micros or 1 ms, frequency 20 or 160 Hz, amplitude 6 to 10 V). Fast-rate right atrial pacing (600 bpm) was used to induce and maintain AF. ECG, blood pressure, and body temperature were monitored telemetrically. One week after the induction of AF, AVN-VS was delivered and maintained for at least 5 weeks. It was found that AVN-VS had a consistent effect on ventricular rate slowing (on average 45+/-13 bpm) over the entire period of observation. Echocardiography showed improvement of cardiac indices with ventricular rate slowing. AVN-VS was well tolerated by the animals, causing no signs of distress or discomfort. Beneficial long-term ventricular rate slowing during AF can be achieved by implantation of a nerve stimulator attached to the epicardial AVN fat pad. This novel concept is an attractive alternative to other methods of rate control and may be applicable in a selected group of patients.
(キーワード): Animals / Atrial Fibrillation / Atrioventricular Node / Disease Models, Animal / Dogs / Electric Stimulation Therapy / Telemetry / Vagus Nerve / Ventricular Function
(出版サイトへのリンク): ● Publication site (DOI): 10.1161/CIRCULATIONAHA.105.568832
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 16260638; ● Search Scopus @ Elsevier (PMID): 16260638; ● Search Scopus @ Elsevier (DOI): 10.1161/CIRCULATIONAHA.105.568832

(DOI: 10.1161/CIRCULATIONAHA.105.568832, PubMed: 16260638) Erwan Donal, Hirotsugu Yamada, Christophe Leclercq and Daniel Herpin :
The Left Atrial Appendage, a Small, Blind-Ended Structure. A Review of Its Echocardiographic Evaluation and Its Clinical Role,
Chest, Vol.128, No.3, 1853-1862, 2005.

(要約): The increasing prevalence of stroke and atrial fibrillation is a stimulus for new therapeutic strategies and also warrants a review of imaging modalities of the most important source of cardiac systemic embolic events: the left atrial appendage (LAA). This blind-ended, complex structure is embryologically distinct from the body of the left atrium and is sometimes regarded as just a minor extension of the atrium. However, it should routinely be analyzed as part of a transesophageal echocardiographic (TEE) examination. A pulsed Doppler TEE analysis of LAA emptying flow should supplement a two-dimensional (2-D) analysis; these examinations have proven to be highly reproducible and to help assess thromboembolic risk. In 2-D imaging, potential thrombus and spontaneous echo contrast should be sought. In addition, LAA plays a hemodynamic role that participates in atrial function and is influenced by various hemodynamic conditions. In view of the embolic risks from a dysfunctional appendage, the LAA is often ligated during cardiac valve surgery. New devices are under evaluation for percutaneous closure of the LAA, and further studies should improve the definition, understanding, and treatment of LAA dysfunction.
(キーワード): Age Factors / Atrial Appendage / Atrial Function, Left / Echocardiography, Doppler, Pulsed / Echocardiography, Transesophageal / Heart Diseases / Heart Rate / Humans / Sex Factors
(出版サイトへのリンク): ● Publication site (DOI): 10.1378/chest.128.3.1853
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 16162795; ● Search Scopus @ Elsevier (PMID): 16162795; ● Search Scopus @ Elsevier (DOI): 10.1378/chest.128.3.1853

(DOI: 10.1378/chest.128.3.1853, PubMed: 16162795) ZB Popovic, JP Sun, Hirotsugu Yamada, J Drinko, K Mauer, NL Greenberg, Y Cheng, CS Moravec, MS Penn, TN Mazgalev and JD Thomas :
Differences in left ventricular long-axis function from mice to humans follow allometric scaling to ventricular size.,
The Journal of Physiology, Vol.568, No.Pt 1, 255-265, 2005.

(要約): While the heart size maintains a constant proportion to body size, heart function parameters, such as heart rate and cardiac output, show a more complex scaling pattern. How these phenomena affect the long-axis left ventricular (LV) function is unknown. We studied 10 mice, 15 rats, 6 rabbits, 8 mongrel dogs and 38 human volunteers. Doppler tissue echocardiography data were postprocessed to reconstruct mitral annulus (MA) peak systolic velocity and displacement. The relationship between MA peak velocity, MA displacement and LV ejection time, and LV end-diastolic volume (and mass) were fit to an allometric (power-law) equation Y=kMbeta. LV mass varied from 0.062 to 255 g, while end-diastolic volume varied from 0.014 to 205 ml. beta values of the relation between LV ejection time and LV end-diastolic volume and mass were 0.247+/-0.017 and 0.267+/-0.018, respectively. beta values of the relationship between MA displacement and LV end-diastolic volume and mass were 0.358+/-0.047 and 0.390+/-0.051 (P<0.023 versus beta of LV ejection time). beta values of the relationship between MA peak systolic velocity and LV end-diastolic volume and mass were 0.096+/-0.012 and 0.100+/-0.013, respectively (P<0.0001 versus 0). Finally, beta values of the relationship between the long-to-short axis displacement ratio and LV end-diastolic volume and mass were 0.077+/-0.017 and 0.086+/-0.019 (P<0.0001 versus 0). We conclude that MA velocity, displacement, and long-to-short axis displacement ratio scale allometrically to heart size. This reduces the relative long-axis contribution to heart function in small mammals.
(キーワード): Animals / Body Weight / Cardiac Output / Diastole / Dogs / Echocardiography, Doppler, Color / Heart / Humans / Mice / Models, Cardiovascular / Organ Size / Rabbits / Rats / Systole / Time Factors / Ventricular Function, Left
(出版サイトへのリンク): ● Publication site (DOI): 10.1113/jphysiol.2005.090779
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 16002448; ● Search Scopus @ Elsevier (PMID): 16002448; ● Search Scopus @ Elsevier (DOI): 10.1113/jphysiol.2005.090779

(DOI: 10.1113/jphysiol.2005.090779, PubMed: 16002448) Erwan Donal, Carlos A Grimm, Hirotsugu Yamada, Yong Jin Kim, Nassir Marrouche, Andrea Natale and James D. Thomas :
Usefulness of Doppler assessment of pulmonary vein and left atrial appendage flow following pulmonary vein isolation of chronic atrial fibrillation in predicting recovery of left atrial function,
The American Journal of Cardiology, Vol.95, No.8, 941-947, 2005.

(要約): Atrial fibrillation (AF) is a widespread condition that causes significant morbidity and mortality. Recently, pulmonary venous (PV) isolation using radiofrequency ablation has been used successfully to exclude the pulmonary venous ostia, resulting in correction of AF. Further, miniaturized high-frequency ultrasound phased-array transducers currently provide Doppler and 2-dimensional imaging during the ablation procedure. We examined atrial function and its determinants using intracardiac echocardiography before and after PV isolation in 45 patients who had chronic AF (56 +/- 11 years old). PV, left atrial (LA) appendage, and mitral and tricuspid flows were recorded. Recovery of booster pump function (defined by the presence of mitral inflow A wave, LA appendage a-wave, and PV A-reversal wave velocities >10 cm/s) was observed in 39 of 45 patients (86.6%). PV flow systolic wave before and after ablation correlated with the degree of LA booster pump function after PV isolation. An early systolic PV flow peak velocity >57.47 cm/s predicted "good" LA booster pump function recovery with 96% specificity. Diastolic LA appendage emptying in AF correlated (p <0.001) and predicted good LA booster pump function with 92% specificity for velocities >46.4 cm/s. Thus, monitoring LA function during PV isolation for chronic AF is feasible. Most patients recovered LA booster pump function immediately after PV isolation, and the degree of recovery correlated with LA reservoir function. Preserved reservoir function during AF is predictive of satisfactory recovery of booster pump function after PV isolation.
(キーワード): Aged / Atrial Fibrillation / Catheter Ablation / Diastole / Echocardiography, Doppler / Female / Humans / Male / Middle Aged / Mitral Valve / Pulmonary Veins / Regional Blood Flow / Sensitivity and Specificity / Treatment Outcome / Tricuspid Valve
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.amjcard.2004.12.031
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15820159; ● Search Scopus @ Elsevier (PMID): 15820159; ● Search Scopus @ Elsevier (DOI): 10.1016/j.amjcard.2004.12.031

(DOI: 10.1016/j.amjcard.2004.12.031, PubMed: 15820159) Yoko Eto, Hirotsugu Yamada, Joon-Han Shin, Deborah A. Agler, Hiroyuki Tsujino, Jian-Xin Qin, Giuseppe Saracino, Neil L. Greenberg, James D. Thomas and Takahiro Shiota :
Automated mitral annular tracking, --- a novel method for evaluating mitral annular motion using two-dimensional echocardiography ---,
Journal of the American Society of Echocardiography, Vol.18, No.4, 306-312, 2005.

(要約): We developed an automated mitral annular tracking method based on a digital processing of high frame rate cineloop images of 2-dimensional echocardiography. In this study, its feasibility and accuracy was validated in 11 healthy volunteers and 16 patients with left ventricular (LV) dysfunction. The mitral annular excursion measured by automated mitral annular tracking agreed well with that measured by 3-dimensional echocardiography and correlated with LV ejection fraction. The longitudinal mitral annular excursion was reduced whereas the radial one was preserved for patients with LV dysfunction compared with control subjects. The novel automated mitral annular tracking method is clinically feasible and has potential capability to quantify the comprehensive mitral annular motion for evaluating LV function in a clinical setting.
(キーワード): Adult / Automation / Echocardiography / Echocardiography, Three-Dimensional / Feasibility Studies / Female / Humans / Male / Middle Aged / Mitral Valve / Reproducibility of Results / Software / Statistics, Nonparametric / Ventricular Dysfunction, Left
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.echo.2004.11.001
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15846156; ● Search Scopus @ Elsevier (PMID): 15846156; ● Search Scopus @ Elsevier (DOI): 10.1016/j.echo.2004.11.001

(DOI: 10.1016/j.echo.2004.11.001, PubMed: 15846156) 山田博胤, 大木崇 :
組織ドプラー法による左室機能の評価,
日本臨床麻酔学会誌, Vol.25(2), No.2, 111-125, 2005年.

(キーワード): Tissue Doppler imaging / Left ventricular function / Myocardial contraction
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390001204758352384

(CiNii: 1390001204758352384) Yuichi Notomi, Randolph M Setser, Takahiro Shiota, Maureen G Martin-Miklovic, Joan A Weaver, Zoran B Popović, Hirotsugu Yamada, Neil L Greenberg, Richard D White and James D Thomas :
Assessment of left ventricular torsional deformation by Doppler tissue imaging, --- validation study with tagged magnetic resonance imaging ---,
Circulation, Vol.111, No.9, 1141-1147, 2005.

(要約): Left ventricular (LV) torsional deformation is a sensitive index for LV performance but difficult to measure. The present study tested the accuracy of a novel method that uses Doppler tissue imaging (DTI) for quantifying LV torsion in humans with tagged magnetic resonance imaging (MRI) as a reference. Twenty patients underwent DTI and tagged MRI studies. Images of the LV were acquired at apical and basal short-axis levels to assess LV torsion. We calculated LV rotation by integrating the rotational velocity, determined from DTI velocities of the septal and lateral regions, and correcting for the LV radius over time. LV torsion was defined as the difference in LV rotation between the 2 levels. DTI rotational and torsional profiles throughout systole and diastole were compared with those by tagged MRI at isochronal points. Rotation and torsion by DTI were closely correlated with tagged MRI results during systole and early diastole (apical and basal rotation, r=0.87 and 0.90, respectively; for torsion, 0.84; P<0.0001, by repeated-measures regression models). Maximal torsion showed even better correlation (r=0.95, P<0.0001). The present study has shown that DTI can quantify LV torsional deformation over time. This novel method may facilitate noninvasive quantification of LV torsion in clinical and research settings.
(キーワード): Aortic Valve Insufficiency / Aortic Valve Stenosis / Cardiomyopathies / Diastole / Echocardiography, Doppler / Heart Ventricles / Humans / Magnetic Resonance Imaging / Myocardial Contraction / Myocardial Ischemia / Observer Variation / Reproducibility of Results / Rotation / Systole
(出版サイトへのリンク): ● Publication site (DOI): 10.1161/01.CIR.0000157151.10971.98
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15738351; ● CiNii @ 国立情報学研究所 (CRID): 1360292619647241728; ● Search Scopus @ Elsevier (PMID): 15738351; ● Search Scopus @ Elsevier (DOI): 10.1161/01.CIR.0000157151.10971.98

(DOI: 10.1161/01.CIR.0000157151.10971.98, PubMed: 15738351, CiNii: 1360292619647241728) 山口浩司, 野村昌弘, 小柴邦彦, 河野智仁, 木村恵理子, 渡部智紀, 山田博胤, 若槻哲三, 田畑智継, 西角彰良, 伊東進 :
最大酸素摂取量と血中ホモシステインとの関連性:トータル·ヘルス·プロモーション·プラン検診による検討,
心臓, Vol.37, 37-38, 2005年.

(要約): トータル·ヘルス·プロモーション·プランによる健康づくりにより，ホモシステイン濃度の低下がみられ，動脈硬化を減少させると考えられた．

Hirotsugu Yamada, Kent A. Mowrey, Zoran B. Popović, David O. Martin, James D. Thomas and Don W. Wallick :
Coupled pacing improves cardiac efficiency during acute atrial fibrillation with or without cardiac depression,
American Journal of Physiology, Heart and Circulatory Physiology, Vol.287, No.5, H2016-H2022, 2004.

(要約): Coupled pacing (CP), a method for controlling ventricular rate during atrial fibrillation (AF), consists of a single electrical stimulation applied to the ventricles after each spontaneous activation. CP results in a mechanical contraction rate approximately one-half the rate during AF. Paired stimulation in which two electrical stimuli are delivered to the ventricles has also been proposed as a therapy for heart failure. Although paired stimulation enhances contractility, it greatly increases energy consumption. The primary hypothesis of the present study is that CP improves cardiac function during acute AF without a similar increase in energy consumption because of the reduced rate of ventricular contractions. In a canine model, CP was applied during four stages: sinus rhythm (SR), acute AF, cardiac dysfunction (CD), and AF in the presence of cardiac dysfunction. The rate of ventricular contraction decreased in all four stages as the result of CP. In addition, we determined the changes in external cardiac work, myocardial oxygen consumption, and myocardial efficiency in the each of four stages. CP partially reversed the effects of AF and CD on external cardiac work, whereas myocardial oxygen consumption increased only moderately. In all stages but SR, CP increased myocardial efficiency because of the marked increases in cardiac work compared with the moderate increases in total energy consumed. Thus this pacing therapy may be a viable therapy for patients with concurrent atrial fibrillation and heart failure.
(キーワード): Acute Disease / Animals / Atrial Fibrillation / Cardiac Pacing, Artificial / Dogs / Electrocardiography / Heart / Myocardial Contraction / Myocardium / Oxygen Consumption / Ventricular Function
(出版サイトへのリンク): ● Publication site (DOI): 10.1152/ajpheart.00347.2004
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15284067; ● Search Scopus @ Elsevier (PMID): 15284067; ● Search Scopus @ Elsevier (DOI): 10.1152/ajpheart.00347.2004

(DOI: 10.1152/ajpheart.00347.2004, PubMed: 15284067) Atul Verma, Nassir F. Marrouche, Hirotsugu Yamada, Richard A. Grimm, Jennifer Cummings, J. David Burkhardt, Fethi Kilicaslan, Mandeep Bhargava, Abdul-Ahmad Karim, James D. Thomas and Andrea Natale :
Usefulness of intracardiac Doppler assessment of left atrial function immediately post-pulmonary vein antrum isolation to predict short-term recurrence of atrial fibrillation,
The American Journal of Cardiology, Vol.94, No.7, 951-954, 2004.

(要約): Doppler assessments of pulmonary venous (PV) and left atrial appendage flows are useful surrogates of left atrial (LA) function, but it is unknown if these can predict atrial fibrillation (AF) recurrence after pulmonary vein antrum isolation. We compared Doppler surrogates of LA function immediately after pulmonary vein antrum isolation in patients with AF recurrence versus matched patients without recurrence. Patients with a 6-month recurrence had significantly lower LA appendage peak emptying velocity (19 +/- 10 vs 29 +/- 11 cm/s) and lower peak PV systolic wave velocity (36 +/- 17 vs 46 +/- 22 cm/s) compared with those without, suggesting that intracardiac Doppler assessment of LA function after AF ablation predicts AF recurrence.
(キーワード): Aged / Atrial Fibrillation / Atrial Function, Left / Blood Flow Velocity / Catheter Ablation / Echocardiography, Doppler / Female / Follow-Up Studies / Heart Atria / Humans / Male / Middle Aged / Predictive Value of Tests / Pulmonary Veins / Recurrence / Systole / Time Factors / Treatment Outcome
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.amjcard.2004.06.039
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15464687; ● Search Scopus @ Elsevier (PMID): 15464687; ● Search Scopus @ Elsevier (DOI): 10.1016/j.amjcard.2004.06.039

(DOI: 10.1016/j.amjcard.2004.06.039, PubMed: 15464687) Zoran B Popović, Hirotsugu Yamada, Kent A Mowrey, Youhua Zhang, Don W Wallick, Richard A Grimm, James D Thomas and Todor N Mazgalev :
Frank-Starling mechanism contributes modestly to ventricular performance during atrial fibrillation,
Heart Rhythm, Vol.1, No.4, 482-489, 2004.

(要約): The aim of this study was to assess whether Frank-Starling mechanism has an independent effect on left ventricular (LV) performance in atrial fibrillation (AF). Ventricular performance in AF depends on variable contractility through the interval-force mechanism based on the ratio of preceding and pre-preceding RR intervals (RR(p)/RR(pp)). The impact of end-diastolic volume (EDV) variability, through the Frank-Starling mechanism, is not well understood. We induced AF in 16 open chest dogs. RR intervals, LV pressure, LV volume, and aortic flow were collected for >400 beats during rapid AF (ventricular cycle length 292 +/- 66 ms). In six of the dogs, additional data were collected while average ventricular cycle length was prolonged from 258 +/- 34 ms to 445 +/- 80 ms by selective vagal nerve stimulation of the AV node. The relations of maximal LV power (LVPower) and peak LV pressure derivative (dP/dt) versus RR(p)/RR(pp) were fitted to the equation y = A * (1 - EXP (RR(p)/RR(pp)min - RR(p)/RR(pp))/C) and the residuals (RES) of these relations were analyzed. LVPower and dP/dt strongly correlated with RR(p)/RR(pp) (r(2) = 0.67 +/- 0.12 and 0.66 +/- 0.12, P < .0001 for all correlations). Importantly, RES-LVPower and RES-dP/dt showed linear correlation with EDV (r(2) = 0.20 +/- 0.14 and r(2) = 0.24 +/- 0.17, P < .01 for all correlations). In the six dogs with slowed average ventricular rate, the slope of both residual relationships (RES-LVPower vs EDV and RES- dP/dt vs EDV) decreased (P < .03 for both). The Frank-Starling mechanism contributes to ventricular performance in AF independently of the interval-force effects of the beat-to-beat variability in cardiac contractility. The Frank-Starling mechanism is sensitive to the average ventricular rate.
(キーワード): Atrial fibrillation / Hemodynamics / Preload / Tachyarrhythmia / Contractility / Frank-Starling mechanism
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.hrthm.2004.06.016
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15851203; ● Search Scopus @ Elsevier (PMID): 15851203; ● Search Scopus @ Elsevier (DOI): 10.1016/j.hrthm.2004.06.016

(DOI: 10.1016/j.hrthm.2004.06.016, PubMed: 15851203) Hideji Tanaka, Takashi Oki, Tomotsugu Tabata, Hirotsugu Yamada, Kenji Harada, Eriko Kimura, Yoshifumi Oishi, Takeo Ishimoto and Susumu Ito :
Losartan improves regional left ventricular systolic and diastolic function in patients with hypertension, --- Accurate evaluation using a newly developed color-coded tissue Doppler imaging technique ---,
Journal of Cardiac Failure, Vol.10, No.5, 412-420, 2004.

(要約): Angiotensin II receptor antagonists have recently been accepted as antihypertensive therapy. Tissue Doppler imaging (TDI) has been developed as a noninvasive tool to assess quantitatively regional myocardial motion abnormalities. This study was designed to determine whether our newly developed technique of color-coded TDI may be a useful means of quantifying the improvement in regional left ventricular (LV) myocardial contractility and relaxation after treatment with losartan in patients with hypertension. Losartan (50 to 100 mg) was administered for 6 months to 37 previously untreated patients with essential hypertension. Averaged myocardial velocity profiles (MVPs) for color-coded TDI were recorded in the ventricular septum and LV posterior wall before and after treatment. Peak myocardial velocities and peak myocardial velocity gradients (MVGs) in the LV walls were determined during systole and early diastole. The plasma concentration of transforming growth factor (TGF)-beta1 also was measured in all patients. Blood pressure and plasma TGF-beta1 level decreased after initiation of losartan therapy. The LV mass index and LV meridional end-systolic wall stress also decreased after treatment with losartan. LV geometry changed from a pattern consistent with concentric hypertrophy to normal geometry in 10 patients and to a pattern consistent with concentric remodeling in 5 patients, and from concentric remodeling to normal geometry in 5 patients after treatment with losartan. The ratio of early to late diastolic filling for the transmitral flow velocity increased after losartan treatment. The peak systolic and early diastolic myocardial velocities and MVGs in the ventricular septum and LV posterior wall increased after treatment with losartan, although the values 6 months after treatment with losartan were still lower than those in normal individuals. There were good correlations between changes in plasma TGF-beta1 level and changes in systolic and early diastolic MVGs 6 months after losartan. However, there were no significant correlations between changes in the systolic blood pressure and LV end-systolic wall stress and changes in the TDI parameters. Losartan improves regional LV function in patients with hypertension. Our newly developed averaged MVP and MVG measurements may be useful for accurately evaluating regional LV myocardial contractility and relaxation in these patients.
(キーワード): Aged / Angiotensin II Type 2 Receptor Blockers / Antihypertensive Agents / Diastole / Echocardiography, Doppler / Female / Humans / Hypertension / Losartan / Male / Middle Aged / Regression Analysis / Systole / Treatment Outcome / Ventricular Function, Left
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.cardfail.2004.01.007
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15470652; ● Search Scopus @ Elsevier (PMID): 15470652; ● Search Scopus @ Elsevier (DOI): 10.1016/j.cardfail.2004.01.007

(DOI: 10.1016/j.cardfail.2004.01.007, PubMed: 15470652) Hirotsugu Yamada, Erwan Donal, Yong-Jin Kim, Deborah A. Agler, Youhua Zhang, Neil L. Greenberg, Todor N. Mazgalev, James D. Thomas and Richard A. Grimm :
The "Pseud-Restrictive" Pattern of Transmitral Doppler Flow Pattern Following Conversion of Atrial Fibrillation to Sinus Rhythm, --- Is Atrial or Ventricular Dysfunction to Blame? ---,
Journal of the American Society of Echocardiography, Vol.17, No.8, 813-818, 2004.

(要約): Patients with paroxysmal atrial fibrillation (AF) who have recently converted from AF to sinus rhythm often exhibit a restrictive Doppler pattern in the transmitral flow (TMF) velocity. However, the mechanism of this phenomenon has not been well defined. We evaluated the temporal change of TMF pattern and hemodynamics after conversion of AF to in sinus rhythm in an animal model. Eight open-chest dogs underwent 3 hours of pacing-induced AF. TMF velocities and pressure data were acquired at baseline (sinus rhythm), immediately after conversion of AF, and every 10 minutes thereafter. Early diastolic TMF velocity was increased immediately after conversion and recovered to the baseline value in 20 minutes. Atrial systolic TMF velocity was reduced after AF and recovered to baseline value in 20 to 30 minutes. Early diastolic/atrial systolic TMF velocity was increased after conversion, and recovered to baseline value in 20 to 30 minutes. The mean left atrial (LA) pressure increased immediately, 10 and 20 minutes after the conversion of AF to sinus rhythm. The left ventricular end-diastolic pressure was increased and positive left ventricular dP/dt and tau were decreased immediately after AF, whereas they recovered within 10 minutes. In conclusion, a pseudorestrictive pattern of TMF after AF occurred as a result of transient LA mechanical functional impairment and increased LA pressure caused by LA stunning. Transient left ventricular diastolic dysfunction also effected the TMF velocity immediately after the conversion from AF to sinus rhythm, although it recovered faster than LA mechanical dysfunction.
(キーワード): Animals / Atrial Fibrillation / Atrial Function, Left / Blood Flow Velocity / Coronary Circulation / Dogs / Echocardiography, Doppler / Echocardiography, Transesophageal / Electrocardiography / Hemodynamics / Mitral Valve / Regression Analysis
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.echo.2004.04.021
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15282482; ● Search Scopus @ Elsevier (PMID): 15282482; ● Search Scopus @ Elsevier (DOI): 10.1016/j.echo.2004.04.021

(DOI: 10.1016/j.echo.2004.04.021, PubMed: 15282482) Takashi Oki, Hideji Tanaka, Hirotsugu Yamada, Tomotsugu Tabata, Yoshifumi Oishi, Takeo Ishimoto, Norio Nagase, Hisanori Shinohara, Koichi Sakabe and Nobuo Fukuda :
Diagnosis of cardiac amyloidosis based on the myocardial velocity profile in the hypertrophied left ventricular wall.,
The American Journal of Cardiology, Vol.93, No.7, 864-869, 2004.

(要約): The myocardial velocity profile (MVP), derived from color-coded tissue Doppler imaging (TDI), can identify transmural heterogeneity based on the physiology and pathology of the myocardium. This study sought to clarify whether the MVP can differentiate cardiac amyloidosis from other causes of left ventricular hypertrophy. We recorded the MVP and determined its myocardial velocity gradient (MVG) in the ventricular septum and left ventricular posterior wall using color-coded TDI in 10 patients with cardiac amyloidosis, in 25 patients with hypertensive hypertrophied left ventricular wall, in 25 patients with asymmetric septal hypertrophy of hypertrophic cardiomyopathy, and in 20 clinically normal controls. End-diastolic ventricular septal thickness was similar among the cardiac amyloidosis, hypertension, and hypertrophic cardiomyopathy groups. Percent systolic thickening of the ventricular septum and left ventricular posterior wall calculated from M-mode left ventricular echocardiograms was lower in the cardiac amyloidosis group than in the hypertension, hypertrophic cardiomyopathy, or control group. Peak MVGs during systole and early diastole were lowest in the cardiac amyloidosis group, followed, in order, by the control, hypertension, and hypertrophic cardiomyopathy groups. The systolic and early diastolic MVPs in the ventricular septum and left ventricular posterior wall showed a characteristic serrated pattern in all patients with cardiac amyloidosis, but not in any other patient groups. In conclusion, MVPs in the ventricular septum and left ventricular posterior wall show a distinctive serrated pattern that may be related to amyloid deposition in the myocardium. Myocardial tissue characterization using color-coded TDI provides diagnostic information in patients with cardiac amyloidosis.
(キーワード): ECHOCARDIOGRAPHIC FEATURES / INFILTRATIVE CARDIOMYOPATHY / CONSTRICTIVE PERICARDITIS / GRADIENT / DIFFERENTIATION / HYPERTENSION / RELAXATION / MOTION / AXIS
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.amjcard.2003.12.025
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15050490; ● Search Scopus @ Elsevier (PMID): 15050490; ● Search Scopus @ Elsevier (DOI): 10.1016/j.amjcard.2003.12.025

(DOI: 10.1016/j.amjcard.2003.12.025, PubMed: 15050490) Hirotsugu Yamada, Takashi Oki, Takashi Yamamoto, Hideji Tanaka, Tomotsugu Tabata, Tetsuzo Wakatsuki, Masahiro Nomura, Susumu Ito and James D. Thomas :
Potential application of tissue Doppler imaging to assess regional left ventricular diastolic function in patients with hypertrophic cardiomyopathy: Comparison with 123I-β-methyl iodophenyl pentadecanoic acid myocardial scintigraphy.,
Clinical Cardiology, Vol.27, No.1, 33-39, 2004.

(要約): Tissue Doppler imaging (TDI) has been utilized to evaluate left ventricular myocardial dysfunction in patients with hypertrophic cardiomyopathy (HCM); however, no clear explanation for the abnormality of TDI variables has been forthcoming. Peak negative myocardial velocity gradient (MVG) derived from TDI may correlate with a disorder of fatty acid metabolism in patients with HCM. Tissue Doppler imaging and 123I-beta-methyl iodophenyl pentadecanoic acid (123I-BMIPP) myocardial scintigraphy were performed in 15 patients with asymmetric septal hypertrophy (mean age 47 +/- 18 years) and in 12 healthy controls (mean age 43 +/- 10 years). In early 123I-BMIPP images, accumulation defects were observed in the ventricular septum in 12 patients and in the posterior wall in 8 patients with HCM. Peak negative MVG in the ventricular septum (1.1 +/- 0.5 vs. 2.8 +/- 0.5, p < 0.0001) and posterior wall (5.2 +/- 1.4 vs. 6.7 +/- 0.8, p < 0.01 ) was significantly lower in the HCM group than in the controls; also, these parameters were significantly lower in patients with than in those without a defect in the region in question. The peak negative MVG in the ventricular septum and posterior wall correlated inversely with the washout rate in all subjects. Peak negative MVG according to TDI is related to disorder of fatty acid metabolism in the regional left ventricular myocardium of patients with HCM.
(キーワード): Cardiomyopathy, Hypertrophic / Case-Control Studies / Diastole / Echocardiography, Doppler, Pulsed / Fatty Acids / Female / Heart Septum / Humans / Iodine Radioisotopes / Iodobenzenes / Male / Middle Aged / Myocardium / Ventricular Dysfunction, Left
(出版サイトへのリンク): ● Publication site (DOI): 10.1002/clc.4960270109
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 14743854; ● Search Scopus @ Elsevier (PMID): 14743854; ● Search Scopus @ Elsevier (DOI): 10.1002/clc.4960270109

(DOI: 10.1002/clc.4960270109, PubMed: 14743854) Tomotsugu Tabata, Richard A. Grimm, Junko Asada, Zoran B. Popovic, Hirotsugu Yamada, Neil L. Greenberg, Don W. Wallick, Youhua Zhang, Shaowei Zhuang, Kent A. Mowrey, James D. Thomas and Todor N. Mazgalev :
Determinants of left ventlicular diastolic function during atrial fibrillation: Beat-by-beat analysis in acute dog experiments.,
American Journal of Physiology, Heart and Circulatory Physiology, Vol.286, No.1, H145-H152, 2004.

(要約): Left ventricular (LV) diastolic function during atrial fibrillation (AF) remains poorly understood due to the complex interaction of factors and beat-to-beat variability. The purpose of the present study was to elucidate the physiological determinants of beat-to-beat changes in LV diastolic function during AF. The RR intervals preceding a given cardiac beat were measured from the right ventricular electrogram in 12 healthy open-chest mongrel dogs during AF. Doppler echocardiography and LV pressure and volume beat-to-beat analyses were performed. The LV filling time (FT) and early diastolic mitral inflow velocity-time integral (E(vti)) were measured using the pulsed Doppler method. The LV end-diastolic volume (EDV), peak systolic LV pressure (LVP), minimum value of the first derivative of LV pressure curve (dP/dt(min)), and the time constant of LV pressure decay (tau) were evaluated with the use of a conductance catheter for 100 consecutive cardiac cycles. Beat-to-beat analysis revealed a cascade of important causal relations. LV-FT showed a significant positive linear relationship with E(vti) (r = 0.87). Importantly, there was a significant positive linear relationship between the RR interval and LV-EDV in the same cardiac beat (r = 0.53). Consequently, there was a positive linear relationship between LV-EDV and subsequent peak systolic LVP (r = 0.82). Furthermore, there were significant positive linear and negative curvilinear relationships between peak systolic LVP and dP/dt(min) (r = 0.95) and tau (r = -0.85), respectively, in the same cardiac beat. In addition, there was a significant negative curvilinear relationship between dP/dt(min) and tau (r = -0.86). We have concluded that the determinants of LV diastolic function in individual beats during AF depend strongly on the peak systolic LVP. This suggests that the major benefit of slower ventricular rate appears related to lengthening of LV filling interval, promoting subsequent higher peak systolic LVP and greater LV relaxation.
(キーワード): Animals / Atrial Fibrillation / Blood Volume / Diastole / Dogs / Echocardiography, Doppler / Heart Rate / Pressure / Systole / Ventricular Function, Left
(出版サイトへのリンク): ● Publication site (DOI): 10.1152/ajpheart.00588.2003
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12958036; ● Search Scopus @ Elsevier (PMID): 12958036; ● Search Scopus @ Elsevier (DOI): 10.1152/ajpheart.00588.2003

(DOI: 10.1152/ajpheart.00588.2003, PubMed: 12958036) Hirotsugu Yamada, David O. Martin, Kent A. Mowrey, Neil L. Greenberg and Don W. Wallick :
The Effects of Coupled Pacing on Cardiac Performance during Acute Atrial Tachycardia and Fibrillation, --- An Old Therapy Revisited for a New Reason ---,
American Journal of Physiology, Heart and Circulatory Physiology, Vol.285, No.6, H2630-H2638, 2003.

(要約): Atrial tachycardia (AT) and fibrillation (AF) result in rapid ventricular rates that are detrimental to optimal cardiac function. The purpose of this study was to determine whether the application of a coupled pacing (CP) regimen would improve ventricular function by decreasing the ventricular rate of mechanical contractions (VRMCs). We simulated AT by pacing either atrium at a rate that resulted in a rapid but regular ventricular rate in seven anesthetized dogs. AF was induced by increasing the atrial pacing rate until atrial activation did not follow the pacing. After the induction of either AT or AF, we applied CP after each intrinsic ventricular activation. We measured the VRMCs and left ventricular (LV) pressures and volumes via a pressure-conductance catheter. The marked reductions in VRMCs during CP resulted in increases in LV end-diastolic volume. The CP resulted in virtually no mechanical contractions, whereas the strength of contractions from the normal electrical activation increased. The increases in the positive LV rate of pressure development over time and LV ejection fraction during CP were the result of postextrasystolic potentiation. The average stroke work (area of the pressure-volume loops) increased as a result of CP during both AT and AF. Despite the large increases in stroke volume (approximately 2x) during CP, the changes in cardiac output were moderate because the VRMCs markedly decreased (approximately 1/2). We conclude that CP therapy may be a viable therapy for slowing the heart rate and improving cardiac performance in patients with AT and AF.
(キーワード): Acute Disease / Animals / Aorta / Atrial Fibrillation / Blood Pressure / Dogs / Electric Stimulation Therapy / Myocardial Contraction / Pacemaker, Artificial / Stroke Volume / Tachycardia, Ectopic Atrial / Vascular Resistance / Ventricular Function, Left
(出版サイトへのリンク): ● Publication site (DOI): 10.1152/ajpheart.00393.2003
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12893639; ● Search Scopus @ Elsevier (PMID): 12893639; ● Search Scopus @ Elsevier (DOI): 10.1152/ajpheart.00393.2003

(DOI: 10.1152/ajpheart.00393.2003, PubMed: 12893639) Nassir F Marrouche, David O Martin, Oussama Wazni, Marc A Gillinov, Allan Klein, Mandeep Bhargava, Eduardo Saad, Dianna Bash, Hirotsugu Yamada, Wael Jaber, Robert Schweikert, Patric Tchou, Ahmad Abdul-Karim, Walid Saliba and Andrea Natale :
Phased-Array Intracardiac Echocardiography Monitoring During Pulmonary Vein Isolation in Patients With Atrial Fibrillation., --- Impact on Outcome and Complications. ---,
Circulation, Vol.107, No.21, 2710-2716, 2003.

(要約): The objective of this study was to assess the impact of intracardiac echocardiography (ICE) on the long-term success and complications in patients undergoing pulmonary vein isolation (PVI) for treatment of atrial fibrillation (AF). Three hundred fifteen patients underwent PVI for treatment of AF. Each patient underwent ostial isolation of all PVs using a cooled-tip ablation catheter. PVI was performed using circular mapping (CM) alone (group 1, 56 patients), CM and ICE (group 2, 107 patients), and CM and ICE with titration of radiofrequency energy based on visualization of microbubbles by ICE (group 3, 152 patients). After a mean follow-up time of 417+/-145 days, 19.6% (11 of 56), 16.8% (18 of 107), and 9.8% (15 of 152) of patients in groups 1, 2, and 3 experienced recurrence of AF, respectively. Moreover, whereas no group 3 patient experienced severe (>70%) PV stenosis, severe PV stenosis was documented in 3 (3.5%) of 56 patients in group 1 and in 2 (1.8%) of 107 patients in group 2 (P<0.05). No embolic events were detected in group 3 patients. Intracardiac echocardiography improves the outcome of cooled-tip PVI. Power adjustment guided by direct visualization of microbubble formation reduces the risk of PV stenosis and improves long-term cure.
(キーワード): Atrial Fibrillation / Catheter Ablation / Constriction, Pathologic / Disease-Free Survival / Echocardiography / Female / Follow-Up Studies / Humans / Male / Middle Aged / Monitoring, Intraoperative / Pulmonary Veins / Recurrence / Treatment Outcome / Ultrasonography, Interventional
(出版サイトへのリンク): ● Publication site (DOI): 10.1161/01.CIR.0000070541.83326.15
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12756153; ● Search Scopus @ Elsevier (PMID): 12756153; ● Search Scopus @ Elsevier (DOI): 10.1161/01.CIR.0000070541.83326.15

(DOI: 10.1161/01.CIR.0000070541.83326.15, PubMed: 12756153) Sayuri Fujimoto, Takashi Oki, Tomotsugu Tabata, Hideji Tanaka, Hirotsugu Yamada, Yoshifumi Oishi, Takeo Ishimoto, Susumu Ito, Yasuhiko Abe and Ryoichi Kanda :
Novel approach to the quantitation of regional left ventricular systolic and diastolic function using tissue Doppler imaging to create a myocardial velocity profile and gradient,
Circulation Journal, Vol.67, No.5, 416-422, 2003.

(要約): The myocardial velocity profile (MVP) and gradient (MVG) between the endocardium and epicardium of the left ventricular (LV) wall measured by color-coded tissue Doppler imaging (TDI) are new indices for evaluating regional LV myocardial function. However, accurate recording and measurement of the MVP is difficult using conventional methodology because of the stochastic nature of the ultrasound signal; that is, the effect of speckled noise. The aim of this study was to validate the accuracy and establish the validity of a newly developed method for measuring the MVP and MVG using 10 clinically normal controls and 10 patients with a hypertensive hypertrophied LV posterior wall. A non-isotropic, averaging algorithm was developed that was capable of obtaining a stable MVP (averaged MVP). Averaged MVP was recorded using parasternal, LV short-axis, color-coded TDI, placing regions of interest along the LV posterior wall with the reference point for angle-correction being at the center of LV contraction. The velocity from epicardium to endocardium within the region of interest was automatically angle-corrected to calculate the velocity component radially relative to the LV cavity and was spatially averaged along the circumference within the region of interest. Inter- and intraobserber variabilities of measurements were lower in the averaged MVP and MVG than in the conventional MVP and MVG. The correlation coefficients of the linear regression lines of systolic and early diastolic MVPs in the LV posterior wall were higher in all controls and hypertensive patients with the averaged method than with the conventional TDI procedures. The mean peak systolic and early diastolic MVGs were lower in the hypertensive group than in the controls. In conclusion, the newly developed averaged MVP provides a stable and reproducible index for the quantitative assessment of regional LV myocardial function.
(キーワード): Adult / Algorithms / Diastole / Echocardiography, Doppler, Color / Female / Heart Rate / Humans / Hypertrophy, Left Ventricular / Image Processing, Computer-Assisted / Male / Middle Aged / Prospective Studies / Regression Analysis / Reproducibility of Results / Systole / Ventricular Dysfunction, Left / Ventricular Function, Left
(出版サイトへのリンク): ● Publication site (DOI): 10.1253/circj.67.416
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12736480; ● Search Scopus @ Elsevier (PMID): 12736480; ● Search Scopus @ Elsevier (DOI): 10.1253/circj.67.416

(DOI: 10.1253/circj.67.416, PubMed: 12736480) Takashi Yamamoto, Takashi Oki, Hirotsugu Yamada, Hideji Tanaka, Tomotsugu Tabata, T Ishimoto, Tetsuzo Wakatsuki and Susumu Ito :
Prognostic value of the atrial systolic mitral annular motion velocity in patients with left ventricular systolic dysfunction.,
Journal of the American Society of Echocardiography, Vol.16, No.4, 333-339, 2003.

(要約): Transmitral flow velocity variables are powerful predictors of poor prognosis in patients with left ventricular (LV) systolic dysfunction. However, these variables may not accurately reflect the severity of pulmonary congestion. This study was designed to determine whether the peak atrial systolic mitral annular motion velocity (MA-Aw) measured by pulsed Doppler tissue imaging can predict cardiac death or hospitalization for worsening heart failure in patients with LV systolic dysfunction. MA-Aw was recorded in 96 patients with LV systolic dysfunction who were followed up for 29 +/- 10 months. All patients underwent Doppler echocardiography on entry into the study, and cardiac catheterization was performed in 45 patients. Patients were divided into 3 groups on the basis of the ratio of early (E) to late (A) diastolic filling (E/A) of the transmitral flow velocity: group 1 (n=31; E/A < 1); group 2 (n=37; 1 < or = E/A < 2); and group 3 (n=28; E/A > or = 2). During follow-up, 36 patients (38%) died of cardiac causes and 34 (35%) were hospitalized for worsening heart failure. There were 2 cardiac deaths (6%) in group 1, 14 (39%) in group 2, and 20 (56%) in group 3. The MA-Aw correlated closely with the mean pulmonary capillary wedge pressure. Univariate Cox model analysis showed that MA-Aw < or = 5 cm/s was the most powerful predictor of cardiac death or hospitalization for worsening heart failure compared with clinical, hemodynamic, and the other echocardiographic variables. Furthermore, MA-Aw < or = 5 cm/s was clearly discernible as a good predictor of cardiac mortality on multivariate Cox model and as assessed by Kaplan-Meier method. The MA-Aw obtained by pulsed Doppler tissue imaging is a sensitive index of pulmonary congestion in patients with LV systolic dysfunction. It is a simple and noninvasive outcome measure and can be used to monitor treatment.
(キーワード): PULMONARY VENOUS FLOW / CONGESTIVE-HEART-FAILURE / IDIOPATHIC DILATED CARDIOMYOPATHY / PULSED DOPPLER-ECHOCARDIOGRAPHY / END-DIASTOLIC PRESSURE / FILLING PRESSURES / CARDIAC DISEASE / REGURGITATION / DIFFERENCE / SECONDARY
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0894-7317(02)74537-9
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12712015; ● Search Scopus @ Elsevier (PMID): 12712015; ● Search Scopus @ Elsevier (DOI): 10.1016/S0894-7317(02)74537-9

(DOI: 10.1016/S0894-7317(02)74537-9, PubMed: 12712015) Hirotsugu Yamada, PP Goh, JP Sun, J Odabashian, MJ Garcia, JD Thomas and AL Klein :
Prevalence of left ventricular diastolic dysfunction by Doppler echocardiography: Clinical application of the Canadian consensus guidelines.,
Journal of the American Society of Echocardiography, Vol.15, No.10, 1238-1244, 2002.

(要約): We evaluated diastolic filling patterns using Doppler echocardiography in 520 consecutive patients referred to our laboratory for transthoracic echocardiograms retrospectively and applied the standard guidelines used to characterize left ventricular (LV) diastolic function. Patients were classified by the Canadian consensus guidelines using transmitral and pulmonary venous Doppler echocardiographic parameters to have normal diastolic function or mild (abnormal relaxation), mild-to-moderate, moderate (pseudonormal), or severe (restrictive) diastolic dysfunction. LV diastolic dysfunction was present in 290 (56%) patients, whereas 167 (45%) patients with a normal LV ejection fraction had abnormal diastolic function. Patients with progressively more abnormal diastolic patterns had greater structural abnormalities with larger left atrial and LV size and lower LV ejection fractions. In the subset of patients with clinical evidence of congestive heart failure (99 patients), the prevalence of primary diastolic heart failure was 38% and most patients had underlying coronary or hypertensive heart disease. Standard guidelines of Doppler echocardiographic parameters allow semiquantitation of diastolic function and can be applied to studying large number of patients in a large clinical practice.
(キーワード): Adult / Age Factors / Aged / Aged, 80 and over / Blood Flow Velocity / Canada / Consensus / Diastole / Echocardiography, Doppler / Female / Heart Failure / Humans / Male / Middle Aged / Ohio / Prevalence / Retrospective Studies / Severity of Illness Index / Stroke Volume / Ventricular Dysfunction, Left
(出版サイトへのリンク): ● Publication site (DOI): 10.1067/mje.2002.124877
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12411911; ● Search Scopus @ Elsevier (PMID): 12411911; ● Search Scopus @ Elsevier (DOI): 10.1067/mje.2002.124877

(DOI: 10.1067/mje.2002.124877, PubMed: 12411911) Takuzi Tada, Takashi Oki, Miho Abe, Masako Matsuoka, Tomotsugu Tabata, Hirotsugu Yamada, T Yamamoto, Tetsuzo Wakatsuki and Susumu Ito :
The role of short- and long-axis function in determining late diastolic left ventricular filling in patients with hypertension: Assessment by pulsed Doppler tissue imaging.,
Journal of the American Society of Echocardiography, Vol.15, No.10 Supplement, 1211-1217, 2002.

(要約): Left ventricular (LV) wall motion velocity during atrial systole is mediated by both transmitral flow and LV myocardial compliance at end-diastole. LV wall distensibility along the long- and short-axis during atrial systole and late diastolic LV filling may vary according to the remodeling of LV morphology. We measured LV wall motion velocities along the long and short axes using pulsed Doppler tissue imaging in 127 patients with hypertension to evaluate the relationship between the hemodynamic changes and LV morphology and to determine the role of both long- and short-axis function in late diastolic LV filling. Participants were classified into 3 groups according to LV dimension and end-diastolic wall thickness determined by M-mode echocardiography: group A (n = 62) without LV dilation or hypertrophy, group B (n = 55) with LV hypertrophy, and group C (n = 10) with LV dilation and systolic dysfunction. The time constant of the LV pressure decay during isovolumic diastole and the LV end-diastolic pressure were longest and greatest, respectively, in group C, compared with groups B and A. There were no significant differences in active left atrial emptying volume during atrial contraction determined by computerized echocardiographic 3-dimensional reconstruction among patient and control groups. The peak atrial systolic motion velocity of the LV posterior wall along the long axis was significantly lower in groups B and C, particularly in the latter group, than in group A. The peak atrial systolic motion velocity of the LV posterior wall along the short axis was greatest in group B and was lowest in group C compared with the other groups, respectively. The peak atrial systolic motion velocity of the LV posterior wall was greater along the long axis than the short axis in group A, but was less than the short axis in group B. In conclusion, the long- and short-axis function of the LV wall during atrial systole varies in patients with hypertension according to the severity of hemodynamic and morphologic abnormalities. The degree of LV wall expansion along the short axis is an important factor resulting from the atrial kick, and a determinant of its effectiveness.
(キーワード): TRANSMITRAL FLOW VELOCITY / WALL-MOTION VELOCITIES / CONSTRICTIVE PERICARDITIS / HEALTHY-SUBJECTS / HEART-FAILURE / CARDIOMYOPATHY / INFLOW / ECHOCARDIOGRAPHY / ABNORMALITIES / HYPERTROPHY
(出版サイトへのリンク): ● Publication site (DOI): 10.1067/mje.2002.124007
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12411907; ● Search Scopus @ Elsevier (PMID): 12411907; ● Search Scopus @ Elsevier (DOI): 10.1067/mje.2002.124007

(DOI: 10.1067/mje.2002.124007, PubMed: 12411907) Masako Matsuoka, Takashi Oki, Yuichiro Mishiro, Hirotsugu Yamada, Tomotsugu Tabata, Tetsuzo Wakatsuki and Susumu Ito :
Early systolic mitral annular motion velocities responses to dobutamine infusion predict myocardial viability in patients with previous myocardial infarction.,
American Heart Journal, Vol.143, No.3, 552-558, 2002.

(要約): This study was undertaken for the determination of the correlation between myocardial viability and regional systolic mitral annular motion velocity (MAV) response to dobutamine stress in patients with previous myocardial infarction (MI) with pulsed tissue Doppler scan imaging. The study included 45 patients (mean age, 65 +/- 12 years) with previous MI with 1 major coronary lesion and 30 healthy individuals (mean age, 61 +/- 14 years). 99mTc-methoxyisobutylisonitrile scintigraphy was performed to divide the patients into 2 groups: the viability (+) group (n = 25) and the viability (-) group (n = 20). Dobutamine was infused (at 2, 5, 10, and 20 microg/kg/min), and the peak first and second systolic MAVs (Sw1 and Sw2, respectively) were measured at the level of the mitral annulus corresponding to the infarct regions in the MI group and to the 6 mitral annular sites in the control group. In addition, the left ventricular wall motion score index (WMSI) was determined with 2-dimensional echocardiography. At baseline, the WMSI was significantly greater and the mean Sw1 and Sw2 were significantly lower in both the viability (+) and (-) groups than in the control group, but there were no significant differences between the viability (+) and (-) groups. After dobutamine infusion, the WMSI improved only in the viability (+) group. The mean Sw1 and Sw2 increased significantly with 2 microg/kg/min and 5 microg/kg/min of dobutamine, respectively, in the viability (+) group. With an increase in Sw1 of 2.0 cm/s or more with 5 microg/kg/min of dobutamine, viable myocardium was detected, with a sensitivity of 92% and a specificity of 90%. There were no significant increases in Sw1 or Sw2 in the viability (-) group with dobutamine infusion. Viable left ventricular myocardium is identified with peak early systolic MAV during dobutamine infusion.
(キーワード): VENTRICULAR WALL-MOTION / TISSUE DOPPLER-ECHOCARDIOGRAPHY / STRESS ECHOCARDIOGRAPHY / ATRIOVENTRICULAR PLANE / SHORT AXES / DISPLACEMENT / THROMBOLYSIS / REPERFUSION / REINJECTION / TOMOGRAPHY
(出版サイトへのリンク): ● Publication site (DOI): 10.1067/mhj.2002.121266
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11868065; ● Search Scopus @ Elsevier (PMID): 11868065; ● Search Scopus @ Elsevier (DOI): 10.1067/mhj.2002.121266

(DOI: 10.1067/mhj.2002.121266, PubMed: 11868065) Yukiko Onose, Takashi Oki, Hirotsugu Yamada, Kazuyo Manabe, Yoshimi Kageji, Masako Matsuoka, Takashi Yamamoto, Tomotsugu Tabata, Tetsuzo Wakatsuki and Susumu Ito :
Effect of cilnidipine on left ventricular diastolic function in hypertensive patients as assessed by pulsed Doppler echocardiography and pulsed tissue Doppler imaging.,
Japanese Circulation Journal, Vol.65, No.4, 305-309, 2001.

(要約): The purpose of the present study was to examine the mechanisms of improvement in left ventricular (LV) diastolic function in hypertensive patients treated with cilnidipine, a new and unique calcium antagonist that has both L-type and N-type voltage-dependent calcium channel blocking actions, using pulsed Doppler echocardiography and pulsed tissue Doppler imaging. The study comprised 35 untreated patients with essential hypertension (19 men and 16 women; mean age 65+/-10 years). The peak early diastolic and atrial systolic transmitral flow velocities (E and A, respectively) and their ratio (E/A), and the peak early diastolic and atrial systolic motion velocities (Ew and Aw, respectively) of the LV posterior wall and their ratio (Ew/Aw) were determined in all patients before and after 1, 3 and 6 months on cilnidipine (10 mg/day). One month: Systolic and diastolic blood pressures were significantly decreased. E and E/A were significantly increased, whereas there were no significant changes in Ew and Ew/Aw. Three months: Ew and Ew/Aw were significantly increased compared to those before and 1 month after cilnidipine. Six months: E and E/A were significantly increased compared with before and 3 months after cilnidipine, and Ew and Ew/Aw were significantly increased compared with before cilnidipine. Moreover, the LV mass index was significantly decreased compared to that before cilnidipine. In summary, changes in LV diastolic performance in patients with essential hypertension following cilnidipine treatment were biphasic with an initial increase in early diastolic transmitral flow velocity and a later increase in early diastolic LV wall motion velocity. The initial and later changes can be related to an acute change in afterload and a later improvement in LV relaxation.
(キーワード): Aged / Antihypertensive Agents / Blood Pressure / Calcium Channel Blockers / Calcium Channels, L-Type / Calcium Channels, N-Type / Diastole / Dihydropyridines / Echocardiography, Doppler, Pulsed / Female / Humans / Hypertension / Hypertrophy, Left Ventricular / Male / Middle Aged / Systole / Treatment Outcome / Ventricular Dysfunction, Left / Ventricular Function, Left
(出版サイトへのリンク): ● Publication site (DOI): 10.1253/jcj.65.305
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11316128; ● Summary page in Scopus @ Elsevier: 2-s2.0-0035045829

(DOI: 10.1253/jcj.65.305, PubMed: 11316128, Elsevier: Scopus) Yuichiro Mishiro, Takashi Oki, Hirotsugu Yamada, Yukiko Onose, Masako Matsuoka, Tomotsugu Tabata, Tetsuzo Wakatsuki and Susumu Ito :
Use of angiotensin II stress pulsed tissue Doppler imaging to evaluate regional left ventricular contractility in patients with hypertrophic cardiomyopathy.,
Journal of the American Society of Echocardiography, Vol.13, No.12, 1065-1073, 2000.

(要約): There is controversy concerning whether contract-ility in the nonhypertrophied region of the left ventricular (LV) wall is impaired or normal in patients with hypertrophic cardiomyopathy (HCM). Global LV systolic function decreases with increases in afterload in this disease. This study was performed to identify abnormalities in regional LV contractility along the long and short axes in the setting of HCM with the use of angiotensin II (AT-II) stress pulsed tissue Doppler imaging (PTDI). Angiotensin II was administered intravenously to patients with asymmetric septal hypertrophy (HCM group, n = 21) and age-matched normal volunteers (N group, n = 12). We then measured the percent LV fractional shortening (%FS) and end-systolic circumferential LV wall stress by M-mode echocardiography, LV ejection fraction (LVEF) by 2-dimensional echocardiography, and time-velocity integral (TVI) of LV outflow velocity by pulsed Doppler echocardiography. The peak first and second systolic LV wall motion velocities along the long (L-Sw(1) and L-Sw(2)) and short (S-Sw(1) and S-Sw(2)) axes were measured in the LV posterior wall and ventricular septum with the use of PTDI. The end-systolic circumferential LV wall stress at baseline was significantly lower in the HCM group. The L-Sw(1) and L-Sw(2) for the posterior wall were significantly lower in the HCM group, but the S-Sw(1) and S-Sw(2) for the posterior wall and ventricular septum were similar in the two groups. The %FS, LVEF, TVI, and systolic PTDI variables along both axes for the posterior wall decreased significantly, and end-systolic circumferential LV wall stress increased significantly at AT-II doses of 0.005 or 0.010 microg/kg per minute in the HCM group. No significant changes were found in either group in the systolic PTDI variables (except for L-Sw(1)) for the ventricular septum with AT-II infusion. Contractility along the long and short axes of the nonhypertrophied LV wall is easily impaired with increases in afterload in patients with HCM, resulting in a decrease in global LV systolic function. We found AT-II stress PTDI to be a safe and useful technique for evaluating the regional LV systolic function in this disease.
(キーワード): Analysis of Variance / Angiotensin II / Blood Flow Velocity / Cardiomyopathy, Hypertrophic / Case-Control Studies / Echocardiography, Doppler, Pulsed / Female / Humans / Infusions, Intravenous / Male / Middle Aged / Myocardial Contraction / Vasoconstrictor Agents / Ventricular Dysfunction, Left
(出版サイトへのリンク): ● Publication site (DOI): 10.1067/mje.2000.111010
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11119273; ● Summary page in Scopus @ Elsevier: 2-s2.0-0034524367

(DOI: 10.1067/mje.2000.111010, PubMed: 11119273, Elsevier: Scopus) K Miki, T Shinohara, F Ogushi, S Sone, Hirotsugu Yamada, Y Oishi, Tetsuzo Wakatsuki, Susumu Ito, S Yogita and S Tashiro :
Hepatopulmonary syndrome-discussion of cardiopulmonary parameters,
The Journal of Medical Investigation : JMI, Vol.47, No.3-4, 164-169, 2000.

(要約): We report a 70-year-old man with hepatopulmonary syndrome (HPS) in C liver cirrhosis. Hypoxemia worsened markedly, especially on exertion, while the hepatic function was clinically stable. Contrast echocardiography, 99mTc macroaggregated albumin (99mTcMAA) lung scan, and pulmonary angiography were performed. The findings suggested the presence of both intrapulmonary vascular dilatation and substantial right-to-left shunt. The contribution of intrapulmonary vascular abnormalities in patients with severe liver cirrhosis without abnormal chest radiography and spirometry tests when marked hypoxemia is present should be investigated.
(キーワード): Aged / Hepatopulmonary Syndrome / Humans / Male
(徳島大学機関リポジトリ): ● Metadata: 25094
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11019499; ● Search Scopus @ Elsevier (PMID): 11019499

(徳島大学機関リポジトリ: 25094, PubMed: 11019499) Tomotsugu Tabata, Takashi Oki, Hirotsugu Yamada, Miho Abe, Yukiko Onose and J. D. Thomas :
Relationship between left atrial appendage function and plasma concentration of atrial natriuretic peptide.,
European Journal of Echocardiography, Vol.1, No.2, 130-137, 2000.

(要約): It has been reported that the most intensely granuled cardiocytes secreting atrial natriuretic peptide (ANP) are located in the atrial appendages. To evaluate the mechanisms of ANP release in congestive heart failure. The relationship between ANP and left atrial appendage (LAA) function was evaluated in 36 patients who underwent both transoesophageal echocardiography and cardiac catheterization. ANP level correlated positively with mean pulmonary capillary wedge pressure (mPCWP; r=0.75, P<0.0001), whereas it showed no significant correlation with the mean right atrial pressure. mPCWP correlated positively with the maximal LAA area (LAAa; r=0.79, P<0.0001) and negatively with the LAA ejection fraction during atrial contraction (LAA-EF; r=-0.61, P<0.0001) and peak late diastolic LAA emptying flow velocity (LAAF; r=-0.69, P<0.0001). ANP level correlated negatively with the LAA-EF (r=-0.56, P<0.001) and with LAAF (r=-0.61, P<0.0001). ANP level correlated more closely with the LAAa (r=0.79, P<0.0001) than with maximal LA volume (r=0.34, P<0.05). Multiple stepwise regression analysis selected LAAa as the only factor independently related to the plasma concentration of ANP (ANP=-22.4+28.6 LAAa, r=0.79, P<0.0001). We conclude that the factor most predictive for ANP in patients with left-sided cardiac dysfunction is distension of the LAA wall rather than elevation in the LA pressure or distension of the body of LA. This is consistent with the known distribution of ANP-secreting cardiocytes.
(キーワード): Adult / Aged / Aged, 80 and over / Atrial Function, Left / Atrial Natriuretic Factor / Cardiac Catheterization / Echocardiography, Transesophageal / Heart Failure / Humans / Middle Aged / Multivariate Analysis / Prospective Studies / Pulmonary Wedge Pressure
(出版サイトへのリンク): ● Publication site (DOI): 10.1053/euje.2000.0019
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12086211; ● Search Scopus @ Elsevier (PMID): 12086211; ● Search Scopus @ Elsevier (DOI): 10.1053/euje.2000.0019

(DOI: 10.1053/euje.2000.0019, PubMed: 12086211) Takashi Oki, Yuichiro Mishiro, Hirotsugu Yamada, Yukiko Onose, Masako Matsuoka, Tetsuzo Wakatsuki, Tomotsugu Tabata and Susumu Ito :
Detection of left ventricular regional relaxation abnormalities and asynchrony in patients with hypertrophic cardiomyopathy with the use of tissue Doppler imaging.,
American Heart Journal, Vol.139, No.3, 497-502, 2000.

(要約): It is well known that the distribution and magnitude of left ventricular (LV) hypertrophy are not uniform in patients with hypertrophic cardiomyopathy (HCM), which results in regional heterogeneity of LV early diastolic function. The advent of tissue Doppler imaging (TDI) has allowed the noninvasive evaluation of regional LV wall motion velocities. The aim of this study was to evaluate regional LV relaxation abnormalities and asynchrony noninvasively in patients with HCM by using pulsed and color-coded TDI. We studied 20 patients with asymmetric septal hypertrophy (HCM group) and 18 age-matched normal patients (control group). The peak early diastolic motion velocity (Ew) and time from the aortic component of the second heart sound to the peak of the Ew (II(A)-Ew) were measured by pulsed TDI. The myocardial velocity gradient during early diastole (MVG-Ew) also was measured by color-coded TDI. Mean values for these parameters were determined on the basis of measurements made at 2 sites of the ventricular septum or posterior wall at the levels of chordae tendineae and papillary muscles. The mean Ew and mean MVG-Ew for the ventricular septum and posterior wall were significantly lower, and mean II(A)-Ew was significantly prolonged in the HCM group compared with the control group. This difference was most pronounced in the hypertrophied ventricular septum of the HCM group. The standard deviations of II(A)-Ew for the ventricular septum and posterior wall were significantly greater in the HCM group than in the control group. The time constant of LV pressure decay during isovolumic diastole (tau) correlated inversely with Ew and MVG-Ew and correlated directly with II(A)-Ew. Furthermore, tau correlated directly with the standard deviation of the II(A)-Ew. LV early diastolic function in patients with HCM may be mediated by an augmentation of regional LV relaxation abnormalities and asynchrony.
(キーワード): Adult / Cardiac Catheterization / Cardiomyopathy, Hypertrophic / Diastole / Echocardiography, Doppler, Color / Echocardiography, Doppler, Pulsed / Female / Hemodynamics / Humans / Male / Predictive Value of Tests / Ventricular Dysfunction, Left
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0002-8703(00)90094-2
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10689265; ● Summary page in Scopus @ Elsevier: 2-s2.0-0034060533

(DOI: 10.1016/S0002-8703(00)90094-2, PubMed: 10689265, Elsevier: Scopus) Tomotsugu Tabata, Takashi Oki, Hirotsugu Yamada, Miho Abe, Yukiko Onose, James D. Thomas and Susumu Ito :
Subendocardial motion in hypertrophic cardiomyopathy: assessment from long and short axis views by pulsed tissue Doppler imaging.,
Journal of the American Society of Echocardiography, Vol.13, No.2, 108-115, 2000.

(要約): Tissue Doppler imaging (TDI) is a recently developed technique that allows the instantaneous measurement of intrinsic regional myocardial motion velocity. Pulsed TDI is capable of separately assessing left ventricular (LV) regional motion velocity caused by circumferential and longitudinal fiber contraction. This particular feature of function is still controversial in patients with hypertrophic cardiomyopathy (HC). To better characterize intrinsic circumferential and longitudinal LV systolic myocardial function in HC, we used pulsed TDI to measure short- and long-axis LV motion velocities, respectively. The subendocardial motion velocity patterns at the middle of the LV posterior wall (PW) and ventricular septum (IVS) in LV parasternal and apical long-axis views were recorded by pulsed TDI in 19 patients with nonobstructive HC and in 21 normal controls (NC). Peak short- and long-axis systolic subendocardial velocities in both the LV PW and IVS were significantly smaller in the HC group than in the NC group, and the time to peak velocity was significantly delayed. Furthermore, peak PW systolic velocity was significantly greater along the long axis than along the short axis in the NC group (8.8 +/- 1.5 cm/s vs 8.2 +/- 1.4 cm/s, P <.05), whereas the opposite was observed in the HC group (6.1 +/- 1.2 cm/s vs 7.5 +/- 1.0 cm/s, P <.0001). No significant differences were found in either group between the long- and short-axis IVS velocities (HC: 5.9 +/- 1.4 cm/s vs 5.5 +/- 1.3 cm/s; NC: 7.8 +/- 1.3 cm/s vs 7.9 +/- 1.6 cm/s). By using the capability of pulsed TDI for the evaluation of intrinsic myocardial velocity instantaneously in a specific region and direction, we found impairment of LV myocardial systolic function in patients with HC not only in the hypertrophied IVS but also in the nonhypertrophied LV PW. We also found a greater decrease in LV PW velocities along the long axis than the short axis, suggesting greater impairment of long-axis contraction in patients with HC. Because our HC patients did not appear to have excessive intracavitary pressure, these results suggest that the relatively normal-appearing PW is directly affected by the HC pathologic process.
(キーワード): Adult / Aged / Cardiomyopathy, Hypertrophic / Echocardiography, Doppler, Pulsed / Female / Humans / Male / Middle Aged / Myocardial Contraction / Systole
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10668013; ● Summary page in Scopus @ Elsevier: 2-s2.0-0033955724

(PubMed: 10668013, Elsevier: Scopus) 大木崇, 山田博胤 :
心エコー・ドプラ法による左室拡張機能評価からみた心不全-治療効果と予後-,
Tokyo Heart Journal, Vol.20, 62-71, 2000年. Yuichiro Mishiro, Takashi Oki, Hirotsugu Yamada, Tetsuzo Wakatsuki and Susumu Ito :
Evaluation of left ventricular contraction abnormalities in patients with dilated cardiomyopathy with the use of pulsed tissue doppler imaging,
Journal of the American Society of Echocardiography, Vol.12, No.11, 913-920, 1999. Yukiko Onose, Takashi Oki, Yuichiro Mishiro, Hirotsugu Yamada, Miho Abe, Kazuyo Manabe, Kageji Yoshimi, Tomotsugu Tabata, Tetsuzo Wakatsuki and Susumu Ito :
Influence of aging on systolic left ventricular wall motion velocities along the long and short axes in clinically normal patients determined by pulsed tissue Doppler imaging.,
Journal of the American Society of Echocardiography, Vol.12, No.11, 921-926, 1999. Hirotsugu Yamada, Takashi Oki, Yuichiro Mishiro, Tomotsugu Tabata, Miho Abe, Yukiko Onose, Tetsuzo Wakatsuki and Susumu Ito :
Effect of aging on diastolic left ventricular myocardial velocities measured by pulsed tissue Doppler imaging in healthy subjects.,
Journal of the American Society of Echocardiography, Vol.12, No.7, 574-581, 1999. Takashi Oki, Kazuyo Fukuda, Tomotsugu Tabata, Yuichiro Mishiro, Hirotsugu Yamada, Miho Abe, Yukiko Onose, Tetsuzo Wakatsuki, Arata Iuchi and Susumu Ito :
Effect of an acute increase in afterload on left ventricular regional wall motion velocity in healthy subjects.,
Journal of the American Society of Echocardiography, Vol.12, No.6, 476-483, 1999. Takashi Oki, Tomotsugu Tabata, Yuichiro Mishiro, Hirotsugu Yamada, Miho Abe, Yukiko Onose, Tetsuzo Wakatsuki, Arata Iuchi and Susumu Ito :
Pulsed tissue Doppler imaging of left ventricular systolic and diastolic motion velocities to evaluate differences between long and short axes in healthy subjects.,
Journal of the American Society of Echocardiography, Vol.12, No.5, 308-313, 1999. Yukiko Onose, Takashi Oki, Tomotsugu Tabata, Arata Iuchi, Hirotsugu Yamada and Susumu Ito :
Assessment of temporal relationship between left ventricular relaxation and filling during the early diastole with pulsed Doppler echocardiography and tissue Doppler imaging.,
Japanese Circulation Journal, Vol.63, No.3, 209-215, 1999. Takashi Oki, Arata Iuchi, Tomotsugu Tabata, Yuichiro Mishiro, Hirotsugu Yamada, Miho Abe, Yukiko Onose, Tetsuzo Wakatsuki and Susumu Ito :
Left ventricular systolic wall motion velocities along the long and short axis measured by pulsed tissue Doppler imaging in patients with atrial fibrillation.,
Journal of the American Society of Echocardiography, Vol.12, No.2, 121-128, 1999. Miho Abe, Takashi Oki, Tomotsugu Tabata, Hirotsugu Yamada, Yukiko Onose, Masako Matsuoka, Yuichiro Mishiro, Tetsuzo Wakatsuki and Susumu Ito :
Evaluation of the hemodynamic relationship between the left atrium and left ventricle during atrial systole by pulsed tissue Doppler imaging in patients with left heart failure.,
Japanese Circulation Journal, Vol.63, No.10, 763-769, 1999. Yuichiro Mishiro, Takashi Oki, Arata Iuchi, Tomotsugu Tabata, Hirotsugu Yamada, Miho Abe, Yukiko Onose, Susumu Ito, Hiromu Nishitani, Masafumi Harada and Yoshiaki Taoka :
Regional left ventricular myocardial contraction abnormalities and asynchrony in patients with hypertrophic cardiomyopathy evaluated by magnetic resonance spatial modulation of magnetization myocardial tagging.,
Japanese Circulation Journal, Vol.63, No.6, 442-446, 1999. Hirotsugu Yamada, Takashi Oki, Tomotsugu Tabata, Yuichiro Mishiro, Miho Abe, Yukiko Onose, Tetsuzo Wakatsuki, Arata Iuchi and Susumu Ito :
Assessment of the systolic left ventricular myocardial velocity profile and gradient using tissue Doppler imaging in patients with hypertrophic cardiomyopathy.,
Echocardiography, Vol.16, 775-783, 1999. Takashi Oki, Tomotsugu Tabata, Hirotsugu Yamada, Tetsuzo Wakatsuki, Yuichiro Mishiro, Miho Abe, Yukiko Onose, Arata Iuchi and Susumu Ito :
Left ventricular diastolic properties of hypertensive patients measured by pulsed tissue Doppler imaging.,
Journal of the American Society of Echocardiography, Vol.11, No.12, 1106-1112, 1998. Takashi Oki, Tomotsugu Tabata, Hirotsugu Yamada, Kazuyo Fukuda, Miho Abe, Yukiko Onose, Tetsuzo Wakatsuki, Arata Iuchi and Susumu Ito :
Assessment of abnormal left atrial relaxation by transesophageal pulsed Doppler echocardiography of pulmonary venous flow velocity.,
Clinical Cardiology, Vol.21, No.10, 753-758, 1998. N Fukuda, T Oki, A Iuchi, Tomotsugu Tabata, Hirotsugu Yamada, N Takeichi, H Shinohara, Takeshi Soeki, Y Yui and Y Tamura :
Right heart flow dynamics after tricuspid valve annuloplasty. Characteristics and time course,
Japanese Heart Journal, Vol.39, No.3, 339-346, 1998.

(要約): To evaluate the effect of tricuspid annuloplasty (TAP) on right heart flow dynamics, we analyzed tricuspid inflow velocity pattern, jugular venous pulse and color Doppler flow signal of tricuspid regurgitation (TR) before and after surgery in 16 patients who underwent TAP (TAP group). Cardiac rhythm was atrial fibrillation in all patients. Twelve patients with lone atrial fibrillation served as controls (AF group). Patients in the TAP group were studied before and serially after surgery with a mean follow-up period of 2.7 years. TAP was performed according to the modified De Vega technique in all patients. In a comparison of the most recent data in the TAP group and the data in the AF group, the maximum tricuspid inflow velocity was significantly increased, and both the deceleration time of the tricuspid inflow velocity wave and the y-h interval of the jugular venous pulse were significantly prolonged in the TAP group compared to the AF group. Immediately after surgery, in the TAP group, the area of the TR jet was markedly decreased, and the deceleration time of the tricuspid inflow velocity wave was significantly prolonged compared to those before surgery. The area of the TR jet was dramatically decreased and remained small during the follow-up period. Thus, TAP may produce mild tricuspid stenosis but may also confer sustained preventive effects against TR.
(キーワード): Adult / Aged / Echocardiography, Doppler, Color / Heart / Humans / Jugular Veins / Middle Aged / Postoperative Period / Pulse / Tricuspid Valve / Tricuspid Valve Insufficiency
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 9711185; ● Search Scopus @ Elsevier (PMID): 9711185

(PubMed: 9711185) Hirotsugu Yamada, Takashi Oki, Tomotsugu Tabata, Arata Iuchi and Susumu Ito :
Assessment of left ventricular systolic wall motion velocity using pulsed tissue Doppler imaging: comparison with peak dP/dt of the left ventricular pressure curve.,
Journal of the American Society of Echocardiography, Vol.11, No.5, 442-449, 1998. Takashi Oki, Tomotsugu Tabata, Hirotsugu Yamada, Tetsuzo Wakatsuki, Kazuyo Fukuda, Miho Abe, Yukiko Onose, Arata Iuchi, Nobuo Fukuda and Susumu Ito :
Evaluation of left atrial filling using systolic pulmonary venous flow velocity measurements in patients with atrial fibrillation.,
Clinical Cardiology, Vol.21, No.3, 169-175, 1998. Takashi Oki, Tomotsugu Tabata, Hirotsugu Yamada, Miho Abe, Yukiko Onose, Tetsuzo Wakatsuki, Hiroyuki Fujinaga, Koichi Sakabe, Jiro Ikata, Akiyoshi Nishikado, Arata Iuchi and Susumu Ito :
Right and left ventricular wall motion velocities as diagnostic indicators of constrictive pericarditis.,
The American Journal of Cardiology, Vol.81, No.4, 465-470, 1998. Tomotsugu Tabata, Takashi Oki, Hirotsugu Yamada, Arata Iuchi, Susumu Ito, Takaki Hori, Tetsuya Kitagawa, Itsuo Kato, Hiroshi Kitahata and Shuzo Oshita :
Role of left atrial appendage in left atrial reservoir function as evaluated by left atrial appendage clamping during cardiac surgery.,
The American Journal of Cardiology, Vol.81, No.2, 327-332, 1998. Hirotsugu Yamada, Takashi Oki, Tomotsugu Tabata, Kazuyo Manabe, Kazuyo Fukuda, M Abe, A Iuchi and Susumu Ito :
Differences in transmitral flow velocity pattern during increase in preload in patients with abnormal left ventricular relaxation.,
Cardiology, Vol.89, No.2, 152-158, 1998.

(要約): Changes in transmitral flow (TMF) and pulmonary venous flow (PVF) velocities during increases in preload were compared in patients with a higher peak atrial systolic velocity than peak early diastolic velocity (A/E > 1) for the TMF velocity to determine differences in hemodynamic response. Fifteen patients with dilated hearts, 22 with hypertrophied hearts and 15 control patients were studied. TMF and PVF velocities were recorded by transesophageal pulsed Doppler echocardiography before and during application of lower body positive pressure. The value for peak early diastolic velocity increased, while the isovolumic relaxation time decreased with increases in preload in all groups. The value for peak atrial systolic velocity decreased in the dilated-heart group, but increased in the hypertrophied-heart and control groups. The peak second systolic and early diastolic PVF velocities increased in the dilated- and hypertrophied-heart groups, but did not change in the control group. The peak atrial systolic PVF velocity and the difference in duration of the atrial systolic PVF and TMF velocities increased in the dilated- and hypertrophied-heart groups, and its changing rate was highest in the group with dilated hearts. These results suggest that both peak early diastolic and atrial systolic TMF velocities increase during increases in preload through the Frank-Starling mechanism in hypertrophied hearts. Furthermore, the left ventricular functional reserve was lower in the dilated-heart group. Thus, TMF and PVF velocities respond differently during increases in preload, depending on the underlying heart disease.
(キーワード): Blood Flow Velocity / Cardiomegaly / Cardiomyopathy, Dilated / Echocardiography, Doppler, Pulsed / Echocardiography, Transesophageal / Humans / Middle Aged / Mitral Valve / Myocardial Contraction / Pulmonary Veins / Ventricular Dysfunction, Left
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 9524018; ● Search Scopus @ Elsevier (PMID): 9524018

(PubMed: 9524018) H Fujinaga, Tetsuzo Wakatsuki, Koichi Sakabe, Jiro Ikata, Hirotsugu Yamada, Akiyoshi Nishikado, Takashi Oki and Susumu Ito :
Characteristics of Coronary Flow Velocity in Constrictive Pericarditis,
Catheterization and Cardiovascular Diagnosis, Vol.44, 61-64, 1998. Takashi Oki, Arata Iuchi, Tomotsugu Tabata, Hirotsugu Yamada, Kazuyo Manabe and Susumu Ito :
Transesophageal pulsed Doppler echocardiographic study of systolic flow velocity patterns of the pulmonary vein in patients with atrial fibrillation.,
Echocardiography, Vol.15, 147-156, 1998. Takashi Oki, Tomotsugu Tabata, Hirotsugu Yamada, Kazuyo Manabe, Kazuyo Fukuda and Susumu Ito :
Difference in systolic motion velocity of the left ventricular posterior wall in patients with asymmetric septal hypertrophy and prior anteroseptal myocardial infarction: evaluation by pulsed tissue Doppler imaging.,
Japanese Heart Journal, Vol.39, 163-172, 1998. Takashi Oki, Arata Iuchi, Tomotsugu Tabata, Hirotsugu Yamada, Kazuyo Manabe and Susumu Ito :
Left atrial contribution to left ventricular filling in patients with mitral stenosis: combined analysis of transmitral and pulmonary venous flow velocities.,
Echocardiography, Vol.15, 43-50, 1998. Yuichiro Mishiro, Takashi Oki, Arata Iuchi, Tomotsugu Tabata, Hirotsugu Yamada, K. Manabe, K. Fukuda, M. Abe, Y. Onose, T. Ishimoto and Susumu Ito :
Echocardiographic characteristics and causal mechanism of physiologic mitral regurgitation in young normal subjects.,
Clinical Cardiology, Vol.20, No.10, 850-855, 1997. Takashi Oki, Tomotsugu Tabata, Hirotsugu Yamada, Tetsuzo Wakatsuki, Hisanori Shinohara, Akiyoshi Nishikado, Arata Iuchi, Nobuo Fukuda and Susumu Ito :
Clinical application of pulsed Doppler tissue imaging for assessing abnormal left ventricular relaxation.,
The American Journal of Cardiology, Vol.79, No.7, 921-928, 1997. 酒部宏一, 西角彰良, 若槻哲三, 篠原尚典, 井形次郎, 阿部美保, 由岐中道子, 山田博胤, 田畑智継, 野村昌弘, 井内新, 大木崇, 伊東進 :
単冠動脈症を合併した肥大型心筋症の1例,
呼吸と循環, Vol.45, No.4, 395-398, 1997年. Tomotsugu Tabata, Takashi Oki, Arata Iuchi, Hirotsugu Yamada, Kazuyo Manabe, Kazuyo Fukuda, Miho Abe, Nobuo Fukuda and Susumu Ito :
Evaluation of left atrial appendage function by measurement of changes in flow velocity patterns after electrical cardioversion in patients with isolated atrial fibrillation,
The American Journal of Cardiology, Vol.79, No.5, 615-620, 1997. N Fukuda, T Oki, A Iuchi, Tomotsugu Tabata, Hirotsugu Yamada, Susumu Ito, N Takeichi, H Shinohara, Takeshi Soeki, H Shinomiya, Y Yui and Y Tamura :
Tricuspid inflow and regurgitant flow dynamics after mitral valve replacement: Differences relating to surgical repair of the tricuspid valve,
The Journal of Heart Valve Disease, Vol.6, No.2, 184-188, 1997.

(要約): Changes in tricuspid inflow and regurgitant flow dynamics were evaluated in patients with functional tricuspid regurgitation (TR) who underwent mitral valve replacement (MVR) with and without tricuspid annuloplasty (TAP). In a group of 30 patients, all with atrial fibrillation, 15 underwent TAP performed according to the modified De Vega technique; the remaining 15 did not undergo TAP. Patients were studied before and serially after surgery, using pulsed and color Doppler echocardiography. The mean follow up was 4.7 years in the TAP group and 5.1 years in the non-TAP group. In the TAP group, immediately after surgery, the area of the TR jet decreased markedly, and the deceleration time of the tricuspid inflow velocity wave was significantly prolonged compared with that before surgery. By contrast, in the non-TAP group, both the area of the TR jet and deceleration time of tricuspid inflow velocity were virtually unchanged. The area of the TR jet remained small for a long period in the TAP group, but in non-TAP patients was increased in four cases over seven years, with two patients developing right-sided heart failure. Recent data showed the area of the TR jet to be significantly smaller, with maximum tricuspid inflow velocity significantly increased, and deceleration time of the tricuspid inflow velocity wave significantly prolonged in the TAP group compared with the non-TAP group. In patients with functional tricuspid regurgitation undergoing MVR, concomitant TAP may cause mild tricuspid stenosis, but produces sustained preventive effects against TR. Careful follow up is needed in patients who have not undergone TAP, as TR is not markedly decreased and may even be exacerbated. Aggressive TAP is recommended in patients showing dilatation of the tricuspid annulus, even if TR is mild.
(キーワード): Adult / Aged / Echocardiography, Doppler, Color / Female / Heart Valve Prosthesis / Hemodynamics / Humans / Male / Middle Aged / Mitral Valve / Mitral Valve Stenosis / Postoperative Complications / Prognosis / Treatment Outcome / Tricuspid Valve Insufficiency
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 9130130; ● Search Scopus @ Elsevier (PMID): 9130130

(PubMed: 9130130) Takashi Oki, Tomotsugu Tabata, Hirotsugu Yamada, Kazuyo Manabe, Kazuyo Fukuda, M Abe, A Iuchi, N Fukuda and Susumu Ito :
Cross sectional echocardiographic demonstration of the mechanisms of abnormal interventricular septal motion in congenital total absence of the left pericardium.,
Heart, Vol.77, No.3, 247-251, 1997. Takashi Oki, Nobuo Fukuda, Arata Iuchi, Tomotsugu Tabata, Hirotsugu Yamada, K. Manabe, Y. Kageji, M. Abe and Susumu Ito :
Transesophageal pulsed Doppler echocardiographic evaluation of left atrial systolic performance in hypertrophic cardiomyopathy: combined analysis of transmitral and pulmonary venous flow velocities.,
Clinical Cardiology, Vol.20, No.1, 47-54, 1997. Takashi Oki, Tomotsugu Tabata, Hirotsugu Yamada and Arata Iuchi :
Evaluation of cardiac function by pulsed and continuous Doppler echocardiography and tissue Doppler imaging,
Nippon Rinsho, Vol.55 Suppl Part, 594-598, 1997. Kazuyo Manabe, Takashi Oki, Tomotsugu Tabata, Hirotsugu Yamada, Kazuyo Fukuda, Miho Abe, Arata Iuchi, Nobuo Fukuda and Susumu Ito :
Transesophageal echocardiographic prediction of initially successful electrical cardioversion of isolated atrial fibrillation., --- Effects of left atrial appendage function. ---,
Japanese Heart Journal, Vol.38, 487-495, 1997. Takashi Oki, Nobuo Fukuda, Arata Iuchi, Tomotsugu Tabata, Hirotsugu Yamada, Kazuyo Manabe, Fukuda Kazuyo, Miho Abe, Arata luchi and Susumu Ito :
The 'Sail sound' and tricuspid regulation in Epstein's anomaly: the value of echocardiography in evaluating their mechanisms.,
the Journal Heart Valve Disease, Vol.6, 189-192, 1997. Nobuo Fukuda, Takashi Oki, Arata Iuchi, Tomotsugu Tabata, Hirotsugu Yamada, Susumu Ito, Naoki Takeichi, Hisanori Shinohara, Takeshi Socki, Hirohiko Shinomiya, Yasuko Yui and Yoshiyuki Tamura :
Tricuspid inflow and regurgitant flow dynamics after mitral valve replacement: differences relating to surgical repair of the tricuspid valve.,
the Journal of Heart Valve Disease, Vol.6, 184-188, 1997. Takashi Oki, Arata Iuchi, Tomotsugu Tabata, Hirotsugu Yamada, Kazuyo Manabe, M Abe, N Fukuda and Susumu Ito :
Concealed left ventricular hypertrophy and diastolic dysfunction in hypertrophic cardiomyopathy in the presence of acute left ventricular volume overload: a case report.,
Japanese Heart Journal, Vol.38, 139-144, 1997. Takashi Oki, Nobuo Fukuda, Arata Iuchi, Tomotsugu Tabata, Masato Tanimoto, Kazuyo Manabe, Yoshimi Kageji, Miwa Sasaki, Hirotsugu Yamada and Susumu Ito :
Left atrial systolic performance in the presence of elevated left ventricular end-diastolic pressure: evaluation by transesophageal pulsed Doppler echocardiography of left ventricular inflow and pulmonary venous flow velocities.,
Echocardiography, Vol.14, 23-32, 1997. Miwa Sasaki, Takashi Oki, Arata Iuchi, Tomotsugu Tabata, Hirotsugu Yamada and Susumu Ito :
Relationship between the angiotensin converting enzyme gene polymorphism and the effects of Enalapril on left ventricular hypertrophy and impaired diastolic filling in essential hypertension: M-mode and pulsed Doppler echocardiographic studies.,
Journal of Hypertension, Vol.14, No.12, 1403-1408, 1996.

(要約): To investigate the relationship between the angiotensin converting enzyme (ACE) gene polymorphism and the effects of the ACE inhibitor enalapril on left ventricular hypertrophy and impaired diastolic filling. Enalapril (5-10 mg/day) was administered for 12 months to 60 previously untreated patients with essential hypertension. M-mode and pulsed Doppler echocardiography were performed before and after treatment, and changes in various parameters after treatment with enalapril were examined. ACE gene polymorphism was examined by the polymerase chain reaction method and the patients were classified as having the 190 bp deletion homozygous (DD) genotype, the 490 bp insertion homozygous (II) genotype or the 490 bp insertion 190 bp deletion heterozygous (ID) genotype. The DD genotype was observed in 10 patients (17%), the ID genotype in 24 patients (40%) and the II genotype in 26 patients (43%). Plasma ACE activity before treatment with enalapril was significantly higher in seven patients with DD genotype than it was in 18 patients with ID genotype and in 14 patients with II genotype. In all of the 60 patients, the left ventricular mass index, the peak atrial systolic velocity:early diastolic velocity ratio and the deceleration time from the peak of the early diastolic wave to the baseline in transmitral flow velocity were decreased significantly after treatment with enalapril. The changes in left ventricular mass index and atrial systolic velocity:early diastolic velocity ratio after enalapril administration were significantly greater in the DD genotype group than they were in the other two genotype groups. Enalapril-induced regression of left ventricular hypertrophy and improvement in left ventricular impaired diastolic filling were significantly greater in the DD genotype group than they were in the ID and II genotype groups, suggesting that the circulating and tissue renin-angiotensin systems, particularly the former system, are most active in hypertensive patients with the DD genotype.
(キーワード): Adult / Aged / Angiotensin-Converting Enzyme Inhibitors / Diastole / Echocardiography, Doppler, Pulsed / Enalapril / Female / Genotype / Humans / 高血圧 (hypertension) / Hypertrophy, Left Ventricular / Male / Middle Aged / Peptidyl-Dipeptidase A / Polymorphism, Genetic
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 8986921; ● Summary page in Scopus @ Elsevier: 2-s2.0-0030474233

(PubMed: 8986921, Elsevier: Scopus) Tomotsugu Tabata, Takashi Oki, Nobuo Fukuda, Arata Iuchi, Kazuyo Manabe, Yoshimi Kageji, Miwa Sasaki, Hirotsugu Yamada and Susumu Ito :
Influence of left atrial pressure on left atrial appendage flow velocity patterns in patients in sinus rhythm.,
Journal of the American Society of Echocardiography, Vol.9, No.6, 857-864, 1996. Kazue Yamabe, Masashi Akaike, Michihisa Kato, Fumihiko Tada, Hirotsugu Yamada, Tomoko Arase and Arifumi Kohyama :
The efficacy of inhaled nitic oxide in a patient with acute massive pulmonary thromboembolism.,
Journal of the Japanese Society of Intensive Care Medicine, Vol.3, No.4, 283-287, 1996. Tomotsugu Tabata, Takashi Oki, Nobuo Fukuda, Arata Iuchi, Kazuyo Manabe, Yoshimi Kageji, Miwa Sasaki, Hirotsugu Yamada and Susumu Ito :
Influence of aging on left atrial appendage flow velocity patterns in normal subjects.,
Journal of the American Society of Echocardiography, Vol.9, No.3, 274-280, 1996. Takashi Oki, Nobuo Fukuda, Arata Iuchi, Tomotsugu Tabata, Koichi Kiyoshige, Takashi Fujimoto, Kazuyo Manabe, Hirotsugu Yamada and Susumu Ito :
Changes in left ventricular inflow and pulmonary venous flow velocities during preload alteration on hypertrophic cardiomyopathy.,
The American Journal of Cardiology, Vol.77, No.5, 430-435, 1996. Arata Iuchi, Takashi Oki, Nobuo Fukuda, Tomotsugu Tabata, Kazuyo Manabe, Yoshimi Kageji, Miwa Sasaki, Minori Hama, Hirotsugu Yamada and Susumu Ito :
Changes in transmitral and pulmonary venous flow velocity patterns after cardioversion of atrial fibrillation.,
American Heart Journal, Vol.131, No.2, 270-275, 1996. 山部一恵, 赤池雅史, 加藤道久, 多田文彦, 山田博胤, 荒瀬友子, 神山有史 :
一酸化窒素吸入療法が有効であった急性広汎型血栓塞栓症の1例,
日本集中治療学会雑誌, Vol.3(4), 283-288, 1996年. 山田博胤, 大木崇, 井内新, 田畑智継, 真鍋和代, 福田和代, 佐々木美和, 福田信夫, 伊東進 :
右心内転移をきたした悪性黒色腫の1例,
超音波医学, Vol.23, 29-33, 1996年. Hirotsugu Yamada, Takashi Oki, Arata Iuchi, Tomotsugu Tabata, Kazuyo Manabe, K Fukuda, Miwa Sasaki, Nobuo Fukuda and Susumu Ito :
Malignant melanoma metastasizing to the right heart: a case report.,
Jpn J Med Ultrasonics, Vol.23, 29-33, 1996. Takashi Oki, Nobuo Fukuda, Arata Iuchi, Tomotsugu Tabata, Kazuyo Manabe, Yoshimi Kageji, MIwa Sasaki, Hirotsugu Yamada and Susumu Ito :
A Case of Cardiac Amyloidosis Presenting with Mid- to Late Diastolic Retrograde Flow from the Left Atrium to the Pulmonary Vein: Transesophageal Pulsed Doppler Echocardiographic Observations.,
Echocardiography, Vol.13, 623-626, 1996. Nobuo Fukuda, Takashi Oki, Arata Iuchi, Tomotsugu Tabata, Kazuyo Manabe, Yoshimi Kageji, Miwa Sasaki, Hirotsugu Yamada and Susumu Ito :
Clinical significance of the apical late systolic ejection murmur: a new phonocardiographic sign indicating dynamic mid-left ventricular obstruction.,
Clinical Cardiology, Vol.19, 121-127, 1996. Takashi Oki, Nobuo Fukuda, Arata Iuchi, Tomotsugu Tabata, Kazuyo Manabe, Yoshimi Kageji, Miwa Sasaki, Hirotsugu Yamada and Susumu Ito :
Systolic and diastolic mitral regurgitation in a patient with annulo-aortic ectasia demonstrated by color Doppler flow imaging.,
the Journal of Heart Valve Disease, Vol.5, 254-257, 1996. Nobuo Fukuda, Takashi Oki, Arata Iuchi, Tomotsugu Tabata, Kazuyo Manabe, Miwa Sasaki, Hirotsugu Yamada and Susumu Ito :
Peculiar patterns of aortic regurgitation and carotid pulse due to dysfunction of a Medtronic Hall prosthetic valve: a case report.,
the Journal of Heart Valve Disease, Vol.5, 283-285, 1996. Takashi Oki, Nobuo Fukuda, Arata Iuchi, Tomotsugu Tabata, Hirotsugu Yamada and Susumu Ito :
Possible mechanisms of mitral regurgitation in dilated hearts: a study using transesophageal echocardiography.,
Clinical Cardiology, Vol.19, 639-643, 1996. Takashi Oki, Nobuo Fukuda, Arata Iuchi, Tomotsugu Tabata, Hirotsugu Yamada and Susumu Ito :
Assessment of left atrial pressure and volume changes during atrial systole with transesophageal pulsed Doppler echocardiography of transmitral and pulmonary venous flow velocities.,
Japanese Heart Journal, Vol.37, 333-342, 1996. Nobuo Fukuda, Takashi Oki, Arata Iuchi, Tomotsugu Tabata, Kazuyo Manabe, Yoshimi Kageji, Miwa Sasaki, Hirotsugu Yamada and Susumu Ito :
Predisposing factors of severe mitral regurgitation in idiopathic mitral valve prolapse.,
The American Journal of Cardiology, Vol.76, No.7, 503-507, 1995. Nobuo Fukuda, Takashi Oki, Arata Iuchi, Tomotsugu Tabata, Kazuyo Manabe, Yoshimi Kageji, Miwa Sasaki, Hirotsugu Yamada and Susumu Ito :
Pulmonary and systemic venous flow patterns assessed by transesophageal Doppler echocardiography in congenital absence of the pericardium.,
The American Journal of Cardiology, Vol.75, No.17, 1286-1288, 1995. Arata Iuchi, Takashi Oki, Tomotsugu Tabata, Kazuyo Manabe, Yoshimi Kageji, Miwako Sasaki, Miki Hama, Hirotsugu Yamada and Nobuo Fukuda :
Changes in pulmonary venous and transmitral flow velocity patterns after cardioversion of atrial fibrillation,
Journal of Cardiology, Vol.25, No.6, 317-324, 1995. 田畑智継, 大木崇, 福田信夫, 井内新, 藤本卓, 福田和代, 真鍋和代, 影治好美, 佐々木美和, 山田博胤 :
拡大心における僧帽弁逆流の出現機序, --- 経食道心エコー図法による検討 ---,
Journal of Cardiology, Vol.26(Suppl 1), 61-66, 1995年. 福田信夫, 大木崇, 井内新, 田畑智継, 真鍋和代, 影治好美, 濱美紀, 佐々木美和, 山田博胤 :
特発性僧帽弁逸脱における重症僧帽弁逆流の出現要因について,
Journal of Cardiology, Vol.26(Supple ), 17-24, 1995年. 井内新, 大木崇, 田畑智継, 真鍋和代, 影治好美, 佐々木美和, 濱美紀, 山田博胤, 福田信夫 :
心房細動例における除細動前後の肺静脈および僧帽弁口血流速波形変化,
Journal of Cardiology, Vol.25, 317-324, 1995年. Takashi Oki, Nobuo Fukuda, Arata Iuchi, Tomotsugu Tabata, Koichi Kiyoshige, Kazuyo Manabe, Yoshimi Kageji, Miwa Sasaki, M Hama and Hirotsugu Yamada :
Evaluation of left ventricular diastolic hemodynamics from the left ventricular inflow and pulmonary venous flow velocities in hypertrophic cardiomyopathy.,
Japanese Heart Journal, Vol.36, 617-627, 1995. Tomotsugu Tabata, Takashi Oki, Nobuo Fukuda, Arata Iuchi, T Fujimoto, K Fukuda, Kazuyo Manabe, Yoshimi Kageji, Miwa Sasaki and Hirotsugu Yamada :
Mechanism of mitral regurgitation in dilated hearts: transesophageal echocardiographic study.,
Journal of Cardiology, Vol.26, 61-66, 1995. Nobuo Fukuda, Takashi Ooki, Arata Iuchi, Tomotsugu Tabata, Kazuyo Manabe, Miwa Sasaki, Hirotsugu Yamada and Susumu Ito :
The first heart sound in atrial septal defect with reference to atrioventricular valve motion and hemodynamics.,
Japanese Heart Journal, Vol.36, 763-774, 1995. Takashi Oki, Nobuo Fukuda, Tomohiko Kawano, Arata Iuchi, Tomotsugu Tabata, Kazuyo Manabe, Yoshimi Kageji, Miwa Sasaki, Hirotsugu Yamada and Susumu Ito :
Histopathologic studies of innervation of normal and prolapsed mitral valves of humans.,
the Journal of Heart Valve Disease, Vol.4, 496-502, 1995.

MISC

Issei Yagi, Shusuke Yagi, Keisuke Nakanishi, Kazuki Tezuka, K Matsuyama, Y Aibara, T Ishida, H Yoneda, M Yamamoto, Takayuki Ise, Koji Yamaguchi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Tetsuya Kitagawa, Yasuhiko Nishioka and Masataka Sata :
Critical Limb Threatening Ischemia Due to Severe Polyarteritis Nodosa-A Case Report,
Internal Medicine, 2024.

(要約): A delayed diagnosis of polyarteritis nodosa may lead to critical limb-threatening ischemia (CLTI). A 74-year-old woman presented with left-foot pain and was treated with oral vasodilators and antiplatelet agents. However, the distal ischemia progressed to CLTI, including gangrene of the fingers and toes, and bilateral foot dropping appeared because of peroneal nerve paralysis. Angiography of the extremities revealed obstruction and stenosis of medium-sized arteries. Based on the progressive distal gangrene, mononeuropathy multiplex, and pathological findings of necrotic vasculitis, polyarteritis nodosa was diagnosed, and the patient's condition improved. A biopsy and neurological examination are essential for the appropriate diagnosis of PAN and immediate treatment.
(徳島大学機関リポジトリ): ● Metadata: 119631
(出版サイトへのリンク): ● Publication site (DOI): 10.2169/internalmedicine.4149-24
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 39370254; ● Search Scopus @ Elsevier (PMID): 39370254; ● Search Scopus @ Elsevier (DOI): 10.2169/internalmedicine.4149-24

(徳島大学機関リポジトリ: 119631, DOI: 10.2169/internalmedicine.4149-24, PubMed: 39370254) 森博愛, 山田博胤, 衣川尚知 :
心電図セミナー(306),
徳島県医師会報, No.552, 56, 2017年. 森博愛, 山田博胤, 衣川尚知 :
心電図セミナー(304),
徳島県医師会報, No.550, 16, 2017年. T Niki, Takeshi Soeki, Kenya Kusunose, K Yamaguchi, K Koshiba, Tomohito Kawano, Hirotsugu Yamada, Tetsuzo Wakatsuki and Kenji Kangawa :
Elevated Concentration of Interferon-Inducible Protein of 10kd (IP-10) is Associated with Coronary Atherosclerosis.,
Circulation Journal, Vol.72, No.0, 715_OJ233, 2008.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1571698602189478144

(CiNii: 1571698602189478144) K Yamaguchi, Tetsuzo Wakatsuki, Kenya Kusunose, T Niki, K Koshiba, Tomohito Kawano, Hirotsugu Yamada and Takeshi Soeki :
Predictors of Local Hypercoagulability after Sirolimus-Eluting Stent Implantation: Implication for Correlates of Late Stent Thrombosis.,
Circulation Journal, Vol.72, No.0, 249_FRS022, 2008.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1572543027118467968

(CiNii: 1572543027118467968) Takeshi Soeki, T Niki, K Koshiba, Kenya Kusunose, K Yamaguchi, Tomohito Kawano, Hirotsugu Yamada and Tetsuzo Wakatsuki :
Elevated Concentration of Pentraxin 3 is Associated with Coronary Plaque Vulnerability.,
Circulation Journal, Vol.72, No.0, 632_PE499, 2008.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1573105977073314048

(CiNii: 1573105977073314048) Takeshi Soeki, K Koshiba, T Niki, Kenya Kusunose, K Yamaguchi, Tomohito Kawano, Hirotsugu Yamada, Tetsuzo Wakatsuki and Kenji Kangawa :
Ghrelin Attenuates Myocardial Ischemia/Reperfusion Injury via the Extracellular Signal-Regulated Kinase 1/2 and Phosphatidylinositol.,
Circulation Journal, Vol.72, No.0, 145_OE022, 2008.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1571135652234960512

(CiNii: 1571135652234960512) Tetsuzo Wakatsuki, K Yamaguchi, T Niki, Kenya Kusunose, K Koshiba, Takeshi Soeki and Hirotsugu Yamada :
Long-Term Local Inflammatory Response after Coronary Artery Stenting with Drug-Eluting Stent.,
Circulation Journal, Vol.72, 421_PJ456, 2008.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1572824502094771072

(CiNii: 1572824502094771072) Kenya Kusunose, Hirotsugu Yamada, A Iga, T Niki, K Yamaguchi, K Koshiba, Takeshi Soeki and Tetsuzo Wakatsuki :
Left Atrial Volume does not reflect Brain Natriuretic Peptide Levels in Patients with Atrial Fibrillation.,
Circulation Journal, Vol.72, 508_PE367, 2008.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1570009752328732544

(CiNii: 1570009752328732544) Kenya Kusunose, Hirotsugu Yamada, A Iga, T Niki, K Yamaguchi, K Koshiba, Takeshi Soeki and Tetsuzo Wakatsuki :
Importance of Left Atrial Function for the Pseudonormalization of Transmitral Flow Velocity Pattern in Patients with Hypertrophic Cardiomyopathy.,
Circulation Journal, Vol.72, 426_PJ492, 2008.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1572261552141358592

(CiNii: 1572261552141358592) Hirotsugu Yamada, Kenya Kusunose, A Iga, T Niki, K Yamaguchi, K Koshiba, Takeshi Soeki and Tetsuzo Wakatsuki :
E/e' as a Predictor of the Cardiac Response to Increment of Preload in Patients with Atrial Fibrillation.,
Circulation Journal, Vol.72, No.0, S_749, 2008.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1572261552141499008

(CiNii: 1572261552141499008) Tetsuzo Wakatsuki, K Yamaguchi, T Niki, Kenya Kusunose, K Koshiba, Hirotsugu Yamada, Takeshi Soeki, Shusuke Yagi, Takashi Iwase, Masashi Akaike and Masataka Sata :
Long-term endothelial dysfunction after coronary artery stenting with drug-eluting stent associated with local inflammatory response.,
Circulation, Vol.118, S_749, 2008. K Yamaguchi, Tetsuzo Wakatsuki, T Niki, Kenya Kusunose, K Koshiba, Shusuke Yagi, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Local hypercoagulability and endothelial dysfunction after sirolimus-eluting stent implantation: implication for late stent thrombosis.,
Circulation, Vol.118, S_651, 2008. Takeshi Soeki, T Niki, K Koshiba, Kenya Kusunose, K Yamaguchi, Hirotsugu Yamada and Tetsuzo Wakatsuki :
Elevated concentration of Pentraxin 3 is associated with coronary plaque vulnerability.,
Eur Heart J, Vol.29, 505-732, 2008. Tetsuzo Wakatsuki, K Yamaguchi, Kenya Kusunose, T Niki, K Koshiba, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Long-term local inflammatory response after coronary artery stenting with drug-eluting stent.,
Eur Heart J, Vol.29, 505-732, 2008. K Koshiba, Takeshi Soeki, T Niki, Kenya Kusunose, H Yamaguchi, Hirotsugu Yamada and Tetsuzo Wakatsuki :
C-type natriuretic peptide ameliorates the progression of experimental autommune myocarditis.,
Eur Heart J, Vol.29, 505-732, 2008. S Nishio, Hirotsugu Yamada, H Motonari, H Okada, Kenya Kusunose, Y Tadatsu, M Sato, H Hiraoka, H Kawano, Takeshi Soeki, Tetsuzo Wakatsuki and Masashi Akaike :
Assessment of Left Atrial Ejection Force in Patients with Hypertensive Heart Disease.,
Journal of the American Society of Echocardiography, Vol.21, 552, 2008. Kenya Kusunose, Hirotsugu Yamada, S Nishio, M Sato, H Hiraoka, H Kawano, Y Tadatsu, Takeshi Soeki, Tetsuzo Wakatsuki and Masashi Akaike :
Importance of Left Atrial Function in Cardiac Response to Increment of Preload in Patients with Old Myocardial Infarction: Assessment by Automated Left Atrial Volume Tracking Method.,
Journal of the American Society of Echocardiography, Vol.21, 552, 2008. S Nishio, Hirotsugu Yamada, H Motonari, Kenya Kusunose, Y Tadatsu, M Sato, H Hiraoka, H Kawano, Takeshi Soeki, Tetsuzo Wakatsuki and Masashi Akaike :
Beat-To-Beat Variation of Mitral Annular Velocities in Atrial Fibrillation.,
Journal of the American Society of Echocardiography, Vol.21, 550, 2008. Hirotsugu Yamada, Kenya Kusunose, S Nishio, Y Tadatsu, M Sato, H Hiraoka, H Kawano, T Niki, K Yamaguchi, K Koshiba, Takeshi Soeki, Tetsuzo Wakatsuki and Masashi Akaike :
The Mitral L-Wave Predicts the Cardiac Response to Preload Increment in Atrial Fibrillation.,
Journal of the American Society of Echocardiography, Vol.21, 545, 2008. S Nishio, Hirotsugu Yamada, H Motonari, Kenya Kusunose, Y Tadatsu, M Sato, H Hiraoka, H Kawano, T Niki, K Yamaguchi, K Koshiba, Takeshi Soeki, Tetsuzo Wakatsuki and Masashi Akaike :
Usefulness of Tei Index in Atrial Fibrillation: Assessment by Dual Doppler Echocardiography.,
Journal of the American Society of Echocardiography, Vol.21, 543, 2008. Kenya Kusunose, K Takechi, Hirotsugu Yamada, S Nishio, Y Tadatsu, T Niki, K Yamaguchi, K Koshiba, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike, M Choraku and Y Maeda :
Multicenter Trial for the Validation of Automated Function Imaging in Patients with Local Left Ventricular Asynergy (VANILLA Study).,
Journal of the American Society of Echocardiography, Vol.21, 538, 2008. Kenya Kusunose, Hirotsugu Yamada, S Nishio, T Niki, K Yamaguchi, K Koshiba, Takeshi Soeki, Tetsuzo Wakatsuki and Masashi Akaike :
Role of Left Atrial Function for Pseudonormalization of Transmitral Flow Velocity Pattern in Patients with Hypertrophic Cardiomyopathy.,
Journal of the American Society of Echocardiography, Vol.21, 524, 2008. Hirotsugu Yamada, Kenya Kusunose, Y Uzuuchi, H Niki, T Nakajima, K Yamaguchi, K Koshiba, Tomohito Kawano, Takeshi Soeki and Tetsuzo Wakatsuki :
Assessment of the cardiac response to increment of preload in patients with atrial fibrillation using dual pulsed Doppler echocardiography.,
Journal of the American Society of Echocardiography, Vol.20, 594, 2007. Kenya Kusunose, Hirotsugu Yamada, T Chono, H Niki, T Nakajima, K Yamaguchi, K Koshiba, Tomohito Kawano, Takeshi Soeki, Tetsuzo Wakatsuki, K Aihara and Hiromu Nishitani :
Measurement of left atrial volume curve by advanced 2D tissue tracking technique: validation by contrast multidetector computed tomography.,
Journal of the American Society of Echocardiography, Vol.20, 603, 2007. Kenya Kusunose, Hirotsugu Yamada, T Niki, T Nakajima, K Yamaguchi, K Koshiba, Tomohito Kawano, Takeshi Soeki, Tetsuzo Wakatsuki and Susumu Ito :
Relationship Between the Ratio of Peak Early Diastolic Transmitral Flow and Mitral Annular Velocities and the Plasma B-Type Natriuretic Peptide (BNP) Concentration in Patients with Atrial Fibrillation: Assessment by Simultaneous Recording of Transmitral Flow and Mitral Annular Velocity.,
Journal of the American College of Cardiology, Vol.49, No.9, 137A, 2007. K Matsuoka, M Nishino, A Hashimoto, K Yamagami, T Tamai, H Kato, Y Egami, R Shutta, H Yamaguchi, K Tanaka, J Tanouchi, Y Yamada and Hirotsugu Yamada :
Right Ventricular Apical Pacing Impairs Left Ventricular Torsion as Well as Synchrony.,
Circulation, 2006. Hirotsugu Yamada, H Motonari, Y Fukuda, K Yamaguchi, K Koshiba, Tomohito Kawano, Takeshi Soeki and Tetsuzo Wakatsuki :
Effect of aging on left atrial myocardial strain evaluated by 2D tissue tracking during lower body positive pressure.,
Journal of the American Society of Echocardiography, Vol.19, 613, 2006. Hirotsugu Yamada, Y Fukuda, K Yamaguchi, K Koshiba, Tomohito Kawano, Takeshi Soeki and Tetsuzo Wakatsuki :
Differentiation of left atrial dysfunction by changes in transmitral flow velocities during lower body positive pressure.,
Journal of the American Society of Echocardiography, Vol.19, 613, 2006. Tomotsugu Tabata, Hirotsugu Yamada, S Yamada, A Watanabe, M Daisuke, K Tamura, H Yokoi and Masahiro Nomura :
Difference in the Left Atrial Function Between Patients With Hypertensive Hypertrophy and Hypertrophic Cardiomyopathy Evaluated by Tissue Strain Imaging.,
Journal of the American College of Cardiology, Vol.47, No.4A, 120A, 2006. Takeshi Soeki, Y Fukuda, K Koshiba, K Yamaguchi, Tomohito Kawano, Hirotsugu Yamada, Tetsuzo Wakatsuki, Masahiro Nomura, Kenji Kangawa and Susumu Ito :
Ghrelin Protects Myocardium Against Ischemia/Reperfusion Injury via Inhibiting Myocardial Apoptosis.,
Journal of the American College of Cardiology, Vol.47, No.4A, 308A, 2006. PB Zoran, Hirotsugu Yamada, Y Zhang, RA Grimm, JD Thomas and TN Mazgalev :
Incomplete Relaxation and Excess Left Ventricular End-Diastolic Pressure during Atrial Fibrillation.,
Circulation, 2005. Hirotsugu Yamada, Tomotsugu Tabata, H Tanaka, K Harada, Masahiro Nomura and Susumu Ito :
Long-term left ventricular morphologic change in hypertrophic cardiomyopathy: a relationship with development of atrial fibrillation.,
Journal of the American Society of Echocardiography, Vol.18, 59, 2005. Tomotsugu Tabata, Hirotsugu Yamada, H Tanaka, Y Saito, K Harada, Masahiro Nomura and Susumu Ito :
Pseudonormalization of the transmitral inflow Doppler velocities re-evaluated in relation to the left atrial function using tissue strain imaging.,
Journal of the American Society of Echocardiography, Vol.18, 34, 2005. Hirotsugu Yamada, Tomotsugu Tabata, K Harada, H Tanaka, T Yoshida, Masahiro Nomura and Susumu Ito :
Quantitative assessment of biphasic response to dobutamine by tissue strain echocardiography.,
Journal of the American Society of Echocardiography, Vol.18, 7, 2005. Tomotsugu Tabata, H Tanaka, Hirotsugu Yamada, Y Saito, K Harada, Masahiro Nomura and Susumu Ito :
Quantitative and Direct Assessment of the Left Atrial Reservoir Function Using Tissue Strain Imaging.,
Journal of the American College of Cardiology, Vol.45, No.3A, 274A, 2005. Hirotsugu Yamada, Y Ootaki, ZB Popovic, M Daimon, K Kamohara, DW Wallick, JD Thomas, D Wagoner Van, K Fukamachi and Y Cheng :
Decreased Arrhythmia Vulnerability in a Novel Rabbit Model of Left Ventricular Aneurysm Repair.,
Journal of the American College of Cardiology, Vol.45, No.3A, 198A, 2005. Hirotsugu Yamada, E Kimura, H Tanaka, K Harada, Masahiro Nomura and Susumu Ito :
Effect of Left Ventricular Geometry on Systolic Myocardial Velocity Gradient in Patients With Hypertension.,
Journal of the American College of Cardiology, Vol.45, No.3A, 273A, 2005. ZB Popovic, JP Sun, Hirotsugu Yamada, J Drinko, Y Cheng, K Mauer, CS Moravec and MS Penn :
Left Ventricular Long Axis Function Shows an Atypical Allometric Scaling to Ventricular Size.,
Circulation, Vol.110, No.17, S593, 2004. T Takezako, R Ramchandran, Y Saad, Hirotsugu Yamada, JD Thomas, R Desnoyer, B Fink, DG Harrison and SS Karnik :
Endothelial AT1 Receptor Overexpression Produces Hypotension and Bradycardia in mMice: The Role of Nitric Oxide.,
Circulation, 2004. Y Notomi, T Shiota, MG Martin-Miklovic, ZB Popovic, Hirotsugu Yamada, SJ Oryszak, DW Wallick and RA Grimm :
Effect of Alteration of Left Ventricular Activation Sequence on the Left Ventricular Torsional Deformation in Anesthetized Closed-chest Dogs.,
Circulation, 2004. Hirotsugu Yamada, A Verma, NF Marrouche, A Natale, JD Thomas and RA Grimm :
Intracardiac Doppler echocardiographic assessment of left atrial function pre and post pulmonary vein isolation for prediction of short-term recurrence of atrial fibrillation.,
Journal of the American Society of Echocardiography, Vol.17, 556, 2004. Hirotsugu Yamada, NF Marrouche, A Natale, JD Thomas and RA Grimm :
Comparison of left and right atrial stunning after conversion of chronic atrial fibrillation to sinus rhythm.,
Journal of the American Society of Echocardiography, Vol.17, 507, 2004. A Verma, Hirotsugu Yamada, JE Cummings, JD Burkhardt, Y Khaykin, M Bhargava, AA Karim, RA Grimm and NF Marrouche :
Natale A Intracardiac Doppler assessment of left atrial function immediately Post-Pulmonary Vein Isolation maybe predictive of short-term recurrence of atrial fibrillation.,
Heart Rhythm, Vol.1, S103, 2004. Hirotsugu Yamada, ZB Popovic, WJ Kowalewski, DO Martin, RA Grimm and DW Wallick :
Coupled Pacing Improves Stroke Work Without Increasing Myocardial Oxygen Consumption During Acute Heart Failure and Atrial Fibrillation.,
Heart Rhythm, Vol.1, S67, 2004. ZB Popovic, Hirotsugu Yamada, Y Zhang, DW Wallick, RA Grimm, JD Thomas and TN Mazgalev :
Frank Starling Mechanism Is an Independent Contributor to Ventricular Performance Variability in Atrial Fibrillation.,
Journal of the American College of Cardiology, Vol.43, 106A, 2004.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0735-1097(04)90441-X
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(DOI: 10.1016/S0735-1097(04)90441-X) Y Notomi, RM Setser, T Shiota, MG Martin-Miklovic, JM Kasper, ZB Popovic, Hirotsugu Yamada, DG Deserranno, NL Greenberg, MJ Garcia, RD White and JD Thomas :
Assessment of Left Ventricular Torsional Deformation by Doppler Tissue Imaging: A Validation Study Using Tagged Magnetic Resonance Imaging.,
Journal of the American College of Cardiology, Vol.43, No.5, 372A, 2004.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0735-1097(04)91576-8
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(DOI: 10.1016/S0735-1097(04)91576-8) Y Notomi, T Shiota, B Zoran, ZB Popovic, Hirotsugu Yamada, MG Martin-Miklovic, DG Deserranno, DW Wallick, NL Greenberg, MJ Garcia and JD Thomas :
Assessment of Ventricular Untwisting Recoil Velocity by Doppler Tissue Echocardiography: An Index of Relaxation Time Constant.,
Journal of the American College of Cardiology, Vol.43, No.S1, 189A, 2004.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0735-1097(04)90804-2
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(DOI: 10.1016/S0735-1097(04)90804-2) DW Wallick, Hirotsugu Yamada, ZB Popovic, WJ Kowalewski, NL Greenberg and DO Martin :
Rate Control by Coupled Pacing During Atrial Fibrillation Increases Myocardial Efficiency.,
Journal of the American College of Cardiology, Vol.43, No.S1, 111A, 2004.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0735-1097(04)90463-9
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(DOI: 10.1016/S0735-1097(04)90463-9) Hirotsugu Yamada, Tomotsugu Tabata, JK Drinco, SE Jasper, MS Lauer, JD Thomas and AL Klein :
Clinical Features of Mixed Physiology of Constriction and Restriction.,
Journal of the American College of Cardiology, Vol.43, No.S1, 204A, 2004.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0735-1097(04)90867-4
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(DOI: 10.1016/S0735-1097(04)90867-4) Y Eto, Hirotsugu Yamada, T Shiota, JH Shin, J Qin, DA Agler and G Saracino :
Assessment of Longitudinal and Radial Mitral Annular Movement in Left Ventricular Dysfunction Using Automated Mitral Annular Tracking.,
Circulation, Vol.108, No.17, IV-440, 2003. Y Eto, Hirotsugu Yamada, Y Zhang, DA Agler, E Donal and TN Mazgalev :
Effect of Ventricular Slowing During Atrial Fibrillation on Relationship Between Cycle Length Irregularity and Mitral Annular Velocity: A Chronic Conscious Canine Model.,
Circulation, Vol.108, IV-393, 2003. Hirotsugu Yamada, Y Notomi, E Donal, EB Saad, JD Thomas and RA Grimm :
Left Atrial Appendage Flow Velocity During Atrial Fibrillation Predicts the Degree of Stunning After Conversion to Sinus Rhythm: Assessment by Intracardiac Echocardiography in Patients Undergoing Pulmonary Vein Isolation Ablation.,
Circulation, Vol.108, IV-646, 2003. Hirotsugu Yamada, NL Greenberg, KA Mowrey, DO Martin and DW Wallick :
Coupled Pacing: A Novel Method To Improve Left Ventricular Pump Function During Atrial Fibrillation with Heart Failure.,
Circulation, Vol.108, IV-325, 2003. Hirotsugu Yamada, Y Zhang, DA Agler, KA Mowrey, DW Wallick and RA Grimm :
Ventricular Slowing by AV Nodal Vagal Stimulation Improves Left Ventricular Systolic Function During Atrial Fibrillation: A Chronic Study in Conscious Canines.,
Circulation, Vol.108, IV-647, 2003. E Kimura, Tomotsugu Tabata, H Tanaka, K Harada, Hirotsugu Yamada, Masahiro Nomura, T Oki and Susumu Ito :
Better Choice of Color Tissue Doppler Imaging Couped with High Dose Dobutamine Stress Echocardiography for Detection Coronary Artery Stenoosis.,
Journal of the American Society of Echocardiography, Vol.16, 528, 2003. Tomotsugu Tabata, H Tanaka, K Harada, E Kimura, Hirotsugu Yamada, Masahiro Nomura, T Oki and Susumu Ito :
Assessment of the Left Ventricular Diastolic Function Independent of Cardiac Translation Using a Newly Developed Tissue Strain Imaging.,
Journal of the American Society of Echocardiography, Vol.16, 556, 2003. H Tanaka, Tomotsugu Tabata, E Kimura, K Harada, Hirotsugu Yamada, Masahiro Nomura, T Oki and Susumu Ito :
Impact of Angiotensin II receptor Antagonist on Left Ventricular Myocardial Function on Hypertensive Hypertrophy: Assessment of Myocardial Velocity Profile and Plasma Vasoactive Peptide.,
Journal of the American Society of Echocardiography, Vol.16, 557, 2003. JP Sun, L Zhang, Hirotsugu Yamada, NL Greenberg, A Borowski, X Zhou, K Wang, L Fan, WJ Stewart, AL Klein and JD Thomas :
Tssue Doppler, Displacement, and Strain Rate in Acute Myocardial Ischemia.,
Journal of the American Society of Echocardiography, Vol.16, 555, 2003. Y Eto, T Shiota, JX Qin, J-H Shin, Hirotsugu Yamada, F Bauer, DA Agler, G Saracino, NL Greenberg and JD Thomas :
Assessment of Left Atrial Conduit Volume in Patients with Hypertrophic Cardiomyopathy Using Real-Time Three-Dimensional Echocardiography.,
Journal of the American Society of Echocardiography, Vol.16, 517, 2003. Z Popovic, Hirotsugu Yamada, AT Askari, JK Drinko, J-H Shin, NL Greenberg, A Morehead, MS Penn and JD Thomas :
Tissue Doppler Echocardiography in Normal and myocardial Infarction Rats: Mitral Annular Velocity, Myocardial Strain and Strain Rate.,
Journal of the American Society of Echocardiography, Vol.16, 545, 2003. Y Notomi, ZB Popovic, Hirotsugu Yamada, D Deserrano, JX Qin, NL Greenberg, JD Thomas and T Shiota :
Temporal Relation Between Left Ventricular Torsional, Longitudinal and Radial Recoil in Early Diastole Assessed by Tissue Doppler Echocardiography.,
Journal of the American Society of Echocardiography, Vol.16, 539, 2003. Y Notomi, Hirotsugu Yamada, Z Popovic, JX Qin, D Deserranno, NL Greenberg, JD Thomas and T Shiota :
Assessment of Left Ventricular Twisting During Exercise Using Tissue Doppler Echocardiography.,
Journal of the American Society of Echocardiography, Vol.16, 539, 2003. E Donal, Hirotsugu Yamada, DW Wallick, M Martin, JD Thomas and LL Rodriguez :
Assessment of Left Atrial Systolic Function During Isovolumetric Atrial Contraction: Interest of the Pulmonary Vein Flow A-Reversal Peak Velocity-About Eight Acute Normal Dogs Experiment.,
Journal of the American College of Cardiology, Vol.41, No.6, 464A, 2003.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0735-1097(03)82560-3
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(DOI: 10.1016/S0735-1097(03)82560-3) Tomotsugu Tabata, H Tanaka, E Kimura, K Harada, Tetsuzo Wakatsuki, T Yamamoto, A Saito, K Uehara, N Kageyama, Hirotsugu Yamada and T Oki :
Longitudinal Myocardial Displacement and Strain Rate in the Hypertrophied Heart Evaluated by Tissue Strain Imaging With Doppler Angle Correction and Tissue Tracking Technique.,
Journal of the American College of Cardiology, Vol.41, No.6, 455A, 2003.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0735-1097(03)82521-4
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(DOI: 10.1016/S0735-1097(03)82521-4) E Donal, RA Grimm, Hirotsugu Yamada, Y Kim, NF Marrouche, A Natale and JD Thomas :
Recovery of Left Atrial Function Following Pulmonary Vein Isolation Using Radiofrequency Ablation in Chronic Atrial Fibrillation: An Intracardiac Doppler Echocardiographic Study.,
Journal of the American College of Cardiology, Vol.41, No.6, 448A, 2003.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0735-1097(03)81368-2
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(DOI: 10.1016/S0735-1097(03)81368-2) Y Notomi, Hirotsugu Yamada, ZB Popovic, JX Qin, NL Greenberg, Y Abe, R Kanda, JD Thomas and T Shiota :
Wringing Motion of Normal Left Ventricle Quantified With Tissue Doppler Echocardiography.,
Journal of the American College of Cardiology, Vol.41, No.6, 441A, 2003.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0735-1097(03)81336-0
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(DOI: 10.1016/S0735-1097(03)81336-0) Hirotsugu Yamada, JK Drinko, AJ Morehead, LL Rodriguez, MJ Garcia, JD Thomas and AL Klein :
Does Pericardiectomy Improve Outcome of Patients With Mixed Constriction and Restriction?,
Journal of the American College of Cardiology, Vol.41, No.6, 160A, 2003.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0735-1097(03)81791-6
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(DOI: 10.1016/S0735-1097(03)81791-6) Hirotsugu Yamada, RA Grimm, NL Greenberg, E Donal, Y Kim, DA Agler, Y Zhang, S Zhuang, KA Mowrey, DR Wagoner Von, TN Mazgalev and JD Thomas :
Ascorbic Acid Accelerates Left Atrial Mechanical Recovery Following a Brief Duration of Atrial Fibrillation.,
Journal of the American College of Cardiology, Vol.41, No.6, 464A, 2003.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0735-1097(03)82561-5
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(DOI: 10.1016/S0735-1097(03)82561-5) Hirotsugu Yamada, Yong Jin Kim, Tomotsugu Tabata, Neil L. Greenberg, Erwan Donal, Deborah A. Agler, Junko Watanabe, Yauhua Zhang, Shaowei Zhuang, Kent A. Mowrey, Todor N. Mazgalev, Don W. Wallick, David Van R. Wagoner, James D. Thomas and Richard A. Grimm :
Correlation of Left Atrial Mechanical and Electrical Remodeling Following Short Duration Atrial Fibrillation.,
Journal of the American College of Cardiology, Vol.39, No.Supplement 2, 376A, 2002.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0735-1097(02)81689-8
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(DOI: 10.1016/S0735-1097(02)81689-8) Yong Jin Kim, Hirotsugu Yamada, Tomotsugu Tabata, Junto Watanabe, Erwan Donal, Deborah A. Agler, Shaowei Zhuang, Youhua Zhang, Don W. Wallick, Kent A. Mowrey, Todor N. Mazgalev, James D. Thomas and Richard A. Grimm :
Left Atrial Reservoir and Active 'Pump' Function after Brief Duration of Atrial Fibrillation: An Acute Animal Study.,
Journal of the American College of Cardiology, Vol.39, No.Supplement 2, 374A, 2002.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0735-1097(02)81680-1
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(DOI: 10.1016/S0735-1097(02)81680-1) Erwan Donal, Hirotsugu Yamada, Neil L. Greenberg, Deborah A. Agler, Zouhua Zhang, Shaowei Zhuang, Don W. Wallick, James D. Thomas and Leonardo Rodriguez :
A new method for assessing left atrial systolic function during isovolumetric atrial contraction in the intact heart. An animal study.,
Journal of the American College of Cardiology, Vol.39, No.Supplement 2, 376A, 2002.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0735-1097(02)81690-4
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1016/S0735-1097(02)81690-4

(DOI: 10.1016/S0735-1097(02)81690-4) Erwan Donal, Hirotsugu Yamada, Yong Jin Kim, Neil L. Greenberg, Deborah A. Agler, Shaowei Zhuang, Youhua Zhang, Don W. Wallick, Kent A. Mowrey, Todor N. Mazgalev, James D. Thomas and Richard A. Grimm :
Early Diastolic Mitral Annular Tissue Doppler Velocities Predicts the Degree of Left Atrial Appendage Stunning Following Conversion to Sinus Rhythm after Short Duration Atrial Fibrillation in a Canine Model.,
Journal of the American College of Cardiology, Vol.39, No.Supplement 2, 374A, 2002.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0735-1097(02)81679-5
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1016/S0735-1097(02)81679-5

(DOI: 10.1016/S0735-1097(02)81679-5) T Zhang, S Zhuang, Hirotsugu Yamada, Y Kim, E Donal, DA Agler, RA Grimm, W Kowalewski, KA Mowrey, DW Wallick, HA III McDonald, K Morgan, J Poore, J Amely-Velez, G Bornzin and TN Mazgalev :
Long-term vagally controlled ventricular rate in atrial fibrillation.,
Europace, Vol.3, A6, 2002. Y Zhang, S Zhuang, Hirotsugu Yamada, Y Kim, E Donal, DA Agler, RA Grimm, W Kawalewski, KA Mowrey, DW Wallick, HA III McDonald, K Morgan, J Poore, J Amely-Velez, J Bornzin and TN Mazgalev :
First successful demonstration of vagally controlled ventricular rate during AF in chronically instrumented dogs.,
Pacing and Clinical Electrophysiology, Vol.25, 583, 2002. Hirotsugu Yamada, DW Wallick, NL Greenberg and DO Martin :
Bigeminal Pacing: A Novel Method to Improve Left Ventricular Pump Function during Atrial Tachycardia and Fibrillation.,
Circulation, Vol.106, II-625, 2002. Hirotsugu Yamada, Y Kim, DA Agler, Z Youhua, S Zhuang, KA Mowrey, Tomotsugu Tabata, TN Mazgalev and RA Grimm :
Importance of Passive Relaxation of the Left Atrial Appendage in Recovery from Stunning after Conversion of Atrial Fibrillation to Sinus Rhythm.,
Circulation, Vol.106, II-560, 2002. Hirotsugu Yamada, E Donal, Y Kim, Tomotsugu Tabata, DA Agler, S Zhuang, Z Youhua, KA Mowrey, TN Mazgalev and RA Grimm :
The "Pseudo-Restrictive" Pattern of Transmitral Doppler Flow Following Conversion of Atrial Fibrillation to Sinus Rhythm: Is Atrial Or Ventricular Dysfunction to Blame?,
Circulation, Vol.106, II-465, 2002. Y Eto, T Shiota, Hirotsugu Yamada, J Qin, H Tsujino, DA Agler, J Shin, G Saracino, NL Greenberg and JD Thomas :
Automated Tracking of Mitral Annular Motion Using Two-Dimensional Echocardiography for Evaluation of Left Ventricular Function: A Comparison With Real-Time Three-Dimensional.,
Circulation, Vol.106, II-507, 2002. H Tanaka, Tomotsugu Tabata, E Kimura, Tetsuzo Wakatsuki, T Yamamoto, A Saito, Hirotsugu Yamada and T Oki :
Temporal change in the left ventricular transmyocardial systolic velocity profile evaluated by color tissue Doppler imaging.,
Journal of the American Society of Echocardiography, Vol.15, 534, 2002. H Tanaka, Tomotsugu Tabata, E Kimura, Tetsuzo Wakatsuki, T Yamamoto, A Saito, Hirotsugu Yamada and T Oki :
Noninvasive assessment of myocardial ischemia and necrosis using a newly developed tissue Doppler myocardial velocity profile.,
Journal of the American Society of Echocardiography, Vol.15, 511, 2002. H Tanaka, Tomotsugu Tabata, E Kimura, Tetsuzo Wakatsuki, T Yamamoto, A Saito, Hirotsugu Yamada and T Oki :
Effect of angiotensin II receptor antagonist on left ventricular myocardial relaxation abnormality in hypertensive patients: evaluation using a newly developed myocardial velocity profile.,
Journal of the American Society of Echocardiography, Vol.15, 496, 2002. Tomotsugu Tabata, T Oki, H Tanaka, E Kimura, Tetsuzo Wakatsuki, T Yamamoto, A Saito and Hirotsugu Yamada :
Quantitative analysis of the left ventricular segmental contractility in the normal subjects using newly developed angle-corrected tissue strain imaging.,
Journal of the American Society of Echocardiography, Vol.15, 490, 2002. Tomotsugu Tabata, T Oki, H Tanaka, E Kimura, Tetsuzo Wakatsuki, T Yamamoto, A Saito and Hirotsugu Yamada :
Novel index for evaluating wall motion abnormality using newly developed angle-corrected tissue strain imaging.,
Journal of the American Society of Echocardiography, Vol.496, 15, 2002. E Kimura, Tomotsugu Tabata, H Tanaka, Tetsuzo Wakatsuki, T Yamamoto, A Saito, Hirotsugu Yamada and T Oki :
Determinants of the left ventricular myocar-dial contractility in patients with hypertension evaluated by echocardiography.,
Journal of the American Society of Echocardiography, Vol.15, 499, 2002. Y Kim, M Jones, T Shiota, JX Qin, NL Greenberg, ZB Popovic, J Kwan, Hirotsugu Yamada, Y Eto, JH Shin, AD Zetts, V Sachdev and JD Thomas :
Impact of infarct size on the end-systolic pressure-area relation of remote non-infarcted myocardium in chronic myocardial infarction: an animal study.,
Journal of the American Society of Echocardiography, Vol.15, 522, 2002. E Donal, Hirotsugu Yamada, Y Kim, Y Zhang, D Agler, RL Grimm, TN Mazgalev and JD Thomas :
Demonstration of vagally controlled ventricular rate potential interest during AF in chronically instrumented dogs. First experience.,
Journal of the American Society of Echocardiography, Vol.15, 504, 2002. E Donal, Hirotsugu Yamada, Y Kim, NL Greenberg, D Agler, S Zhuang, Y Zhang, DW Wallick, TN Mazgalev, JD Thomas and RA Grimm :
Ventricular rate slowing improve left atrial appendage function in atrial fibrillation. Potential interest to vagal nerve stimulation to control atrio-ventricular conduction.,
Journal of the American Society of Echocardiography, Vol.15, 505, 2002. Hirotsugu Yamada, M Jones, T Shiota, JX Qin, Y Kim, NL Greenberg, H Tsujino, Y Abe, R Kanda, AD Zetts and JD Thomas :
Assessment of the longitudinal (apex to base) myocardial velocity profile using tissue Doppler imaging in sheep with chronic myocardial in-farction.,
Journal of the American Society of Echocardiography, Vol.15, 522, 2002. Hirotsugu Yamada, M Jones, T Shiota, JX Qin, Y Kim, NL Greenberg, Y Abe, H Tsujino, R Kanda, AD Zetts and JD Thomas :
Effect of an increase in afterload on tissue Doppler derived systolic myocardial velocity gradient.,
Journal of the American Society of Echocardiography, Vol.15, 494, 2002. Hirotsugu Yamada, RA Grimm, Y Kim, E Donal, NL Greenberg, DA Agler, S Zhuang, Y Zhang, TN Mazgalev and JD Thomas :
"Stunning" after a brief duration of atrial fibrillation is greater in the left atrial appendage than left atrium.,
Journal of the American Society of Echocardiography, Vol.15, 506, 2002. Hirotsugu Yamada, RA Grimm, Y Kim, E Donal, NL Greenberg, DA Agler, Y Zhang, S Zhuang, TN Mazgalev and JD Thomas :
Ascorbic acid accelerates left atrial functional recovery following a short duration of atrial fibrillation.,
Journal of the American Society of Echocardiography, Vol.15, 505, 2002. Hirotsugu Yamada, E Donal, NL Greenberg, M Martin, DW Wallick, S Zhuang, Y Zhang, TE Mazgalev, JD Thomas and L Rodriguez :
Pulmonary Venous Atrial Systolic Flow Reversal Velocity During Ventricular Systole Predicts Left Atrial Elastance: A New Method for Assessing Left Atrial Systolic Function in an Animal Model.,
Journal of the American College of Cardiology, Vol.39, No.S2, 384A, 2002.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0735-1097(02)81727-2
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1016/S0735-1097(02)81727-2

(DOI: 10.1016/S0735-1097(02)81727-2) Tomotsugu Tabata, T Oki, H Tanaka, Y Onose, M Matsuoka, T Tada, T Yamamoto, Tetsuzo Wakatsuki and Hirotsugu Yamada :
Myocardial Characterization of Cardiac Amyloidosis Using Myocardial Velocity Profile: Comparison With Hypertensive Heart Disease.,
Circulation, Vol.104, II-756, 2001. Tomotsugu Tabata, T Oki, Y Onose, M Matsuoka, T Tada, T Yamamoto, Tetsuzo Wakatsuki and Hirotsugu Yamada :
Novel Strategy for Detecting Myocardial Viability by Evaluating Improvement of Early Diastolic Left Ventricular Asynchrony Using Dobutamine Stress Pulsed Tissue Doppler Imaging.,
Circulation, Vol.104, II-749, 2001. Hirotsugu Yamada, M Jones, T Shiota, J Qin Xin, NL Greenberg, Y Kim, J Watanabe, LA Cardon, Y Abe, H Tsujino, R Kanda and JD Thomas :
Assessment of Nonuniformity of the Transmural Myocardial Velocity Profile by Angle Corrected Tissue Doppler Imaging: Characterization of Normal, Transmurally Infarcted and Nontrasmurally Infarcted Myocardium.,
Circulation, Vol.104, II-628, 2001. J Watanabe, Tomotsugu Tabata, Hirotsugu Yamada and RA Grimm :
Rate Control During Atrial Fibrillation Improves Left Ventricular Relaxation Better Than Rhythm Regulation with Atrioventricular Node Ablation.,
Circulation, Vol.104, II-514, 2001. Hirotsugu Yamada, T Oki, H Tanaka, M Matsuoka and T Tada :
The Role of Short and Long Axes Function for Determining Late Diastolic Left Ventricular Filling in Patients with Hypertension.,
Circulation, Vol.104, II-511, 2001. T Yamamoto, T Oki, Hirotsugu Yamada, H Tanaka, M Matsuoka, T Tada, Tetsuzo Wakatsuki and Tomotsugu Tabata :
Prognostic value of atrial systolic mitral annulus motion velocity in patients with dilated failing heart.,
Journal of the American Society of Echocardiography, Vol.14, 428, 2001. H Tanaka, T Oki, Hirotsugu Yamada, Tetsuzo Wakatsuki, Tomotsugu Tabata, R Kanda, Y Abe and T Nabatame :
Early Diastolic Transmural Myocardial Velocity Profile Evaluated by Tissue Doppler Imaging in Normal Subjects and Patients With Left Ventricular Hypertrophy.,
Journal of the American Society of Echocardiography, Vol.14, 469, 2001. Hirotsugu Yamada, T Oki, H Tanaka, Tetsuzo Wakatsuki, Tomotsugu Tabata, R Kanda, Y Abe and T Nabatame :
Accurate Measurement of Systolic Transmural Myocardial Velocity Profile Using Tissue Doppler Imaging in Normal Subjects And Patients with Hypertrophic Cardiomyopathy.,
Journal of the American Society of Echocardiography, Vol.14, 458, 2001. Hirotsugu Yamada, T Oki, H Tanaka, M Matsuoka, T Yamamoto, T Tada, Tetsuzo Wakatsuki and Tomotsugu Tabata :
The Role of Short And Long Axes Function for Determining Late Diastolic Left Ventricular Filling in Patients with Hypertension: Assessment by Pulsed Tissue Doppler Imaging.,
Journal of the American Society of Echocardiography, Vol.14, 480, 2001. Hirotsugu Yamada, T Oki, H Tanaka, M Matsuoka, T Yamamoto, T Tada, Tetsuzo Wakatsuki and Tomotsugu Tabata :
Potential Application of Tissue Doppler Imaging of the Left Ventricular Myocardium in Assessing Regional Diastolic Function in Patients with Hypertrophic cardiomyopathy: Comparison with 1231-b-Methy1 Iodopheny1 Pentadecanoic Acid Myocardial Scintigraphy.,
Journal of the American Society of Echocardiography, Vol.14, 456, 2001. Tomotsugu Tabata, TN Mazgalev, J Watanabe, Y Kim, NL Greenberg, Hirotsugu Yamada, DW Wallick, Y Zhang, S Zhuang, KA Mowrey, RA Grimm and JD Thomas :
Improvement in Left Ventricular Function during Atrial Fibrillation in Subjects with Myocardial Infarction Using Post-ganglionic Vagal Nerve Stimulation.,
PACE, 2001. Hirotsugu Yamada, T Oki, R Kanda, Y Abe and T Nabatame :
Accurate Measurement of Early Diastolic Transmural Myocardial Velocity Profile Using Tissue Doppler Imaging in Normal Subjects and Patients with Left Ventricular Hypertrophy.,
Journal of the American College of Cardiology, Vol.37, 401A, 2001. Hirotsugu Yamada, T Oki, Y Onose, M Matsuoka, T Yamamoto, Tomotsugu Tabata and Tetsuzo Wakatsuki :
Ultrasonic myocardial characterization of cardiac amyloidosis using tissue Doppler imaging.,
Journal of the American Society of Echocardiography, Vol.13, 468, 2000. M Matsuoka, T Oki, Y Mishiro, Hirotsugu Yamada, Y Onose, Tetsuzo Wakatsuki and Tomotsugu Tabata :
Quantitative assessment of left ventricular myocardial viability using systolic mitral annular descent velocity: A study with dobutamine stress pulsed tissue Doppler imaging.,
Journal of the American College of Cardiology, Vol.35, 483A, 2000. Hirotsugu Yamada, T Oki, Y Mishiro, M Abe, Y Onose, Tomotsugu Tabata and Susumu Ito :
Myocardial gradient as an indicator of regional myocardial contraction after cardiac surgery: a study with tissue Doppler imaging.,
Eur Heart J, Vol.20, 682, 1999. Hirotsugu Yamada, T Oki, Y Mishiro, M Abe, Y Onose, Tomotsugu Tabata, Masahiro Nomura and Susumu Ito :
Regional left ventricular myocardial function in hypertrophic cardiomyopathy: assessment by tissue Doppler imaging and 123 I-b-methyliodopheny1 pentadecanoic acid scintigraphy.,
Eur Heart J, Vol.20, 294, 1999. Y Mishiro, T Oki, Hirotsugu Yamada, M Abe, Y Onose, Tomotsugu Tabata and Susumu Ito :
Assessment of left ventricular myocardial viability using mitral annular descent velocity: a study with dobutamine stress pulsed tissue Doppler imaging.,
Eur Heart J, Vol.20, 681, 1999. Hirotsugu Yamada, T Oki, Y Mishiro, M Abe, Y Onose and Tomotsugu Tabata :
Assessment of diastolic left ventricular myopcardial velocity gradient in hypertrophic cardiomyopathy using tissue Doppler imaging: Comparison with 123I-BMIPP myocardial washout ratio.,
Journal of the American Society of Echocardiography, Vol.12, 392, 1999. Y Mishiro, T Oki, Hirotsugu Yamada, M Abe, Y Onose and Tomotsugu Tabata :
Evaluation of left ventricular myocardial viability using mitral annular descent velocity: A study with dobutamine stress pulsed tissue Doppler imaging.,
Journal of the American Society of Echocardiography, Vol.12, 388, 1999. Y Mishiro, T Oki, Hirotsugu Yamada, M Abe, Y Onose and Tomotsugu Tabata :
Mechanism of systolic left ventricular asynchrony in normal heart: A study with Angiotensin II stress pulsed tissue Doppler imaging.,
Journal of the American Society of Echocardiography, Vol.12, 387, 1999. Tomotsugu Tabata, T Oki, Hirotsugu Yamada and JD Thomas :
Left ventricular subendocardial systolic velocity in dilated and hypertrophic cardiomyopathy: Pulsed tissue Doppler imaging of short and long axis motion.,
Journal of the American Society of Echocardiography, Vol.12, 379, 1999. Y Mishiro, T Oki, Hirotsugu Yamada, M Abe, Y Onose and Tomotsugu Tabata :
Response of left ventricular systolic wall motion velocity during low-dose Angiotensin II stress tissue Doppler imaging in patients with hypertrophic cardiomyopathy.,
Journal of the American College of Cardiology, Vol.33, 465A, 1999. Y Mishiro, T Oki, A Iuchi, Hirotsugu Yamada, M Abe, Y Onose and Tomotsugu Tabata :
Assessment of early diastolic left ventricular regional myocardial function in patients with hypertrophic cardiomyopathy using tissue Doppler imaging and magnetic resonance myocardial tagging.,
Journal of the American College of Cardiology, Vol.33, 485A, 1999. Y Mishiro, T Oki, A Iuchi, Tomotsugu Tabata, Hirotsugu Yamada, M Abe, Y Onose, K Manabe, Y Kageji, K Fukuda, Susumu Ito, Y Taoka and Hiromu Nishitani :
Assessment of early diastolic left ventricular regional myocardial function in patients with hypertrophic cardiomyopathy using tissue Doppler imaging and magnetic resonance myocardial tagging.,
Eur Heart J, Vol.19, 9, 1998. Tomotsugu Tabata, T Oki, Hirotsugu Yamada, K Fukuda, M Abe, Y Onose, Tetsuzo Wakatsuki, H Fujinaga, K Sakabe, J Ikata, Akiyoshi Nishikado and A Iuchi :
Relationship between left atrial appendage function and plasma concentration of atrial natriuretic peptide.,
Circulation, Vol.96, A209, 1997. Hirotsugu Yamada, T Oki, Tomotsugu Tabata, M Abe, K Manabe, K Fukuda, A Iuchi and Susumu Ito :
Evaluation of left atrial relaxation abnormality using pulmonary venous flow velocity and interatrial septal motion.,
Eur Heart J, Vol.18, 477, 1997. M Abe, T Oki, Tomotsugu Tabata, Hirotsugu Yamada, K Manabe, K Fukuda, A Iuchi and Susumu Ito :
Differentiation of left ventricular diastolic wall motion velocities between aortic and mitral regurgitation using tissue Doppler imaging.,
Eur Heart J, Vol.18, 327, 1997. K Fukuda, T Oki, Tomotsugu Tabata, K Manabe, Hirotsugu Yamada, M Abe, A Iuchi and Susumu Ito :
Relationship between left ventricular regional wall motion abnormalities and mitral annular descent velocities in patients with myocardial infarction and dilated cardiomyopathy: a study with tissue Doppler imaging.,
Eur Heart J, Vol.18, 103, 1997. Tomotsugu Tabata, T Oki, Hirotsugu Yamada, M Abe, K Manabe, K Fukuda, Tetsuzo Wakatsuki, K Sakabe, A Iuchi and Susumu Ito :
Relationship between left atrial appendage function and plasma concentration of atrial natriuretic peptide.,
Eur Heart J, Vol.18, 328, 1997. Hirotsugu Yamada, T Oki, Tomotsugu Tabata, K Manabe, K Fukuda, M Abe, A Iuchi, N Fukuda and Susumu Ito :
Influence of aging on early diastolic and atrial systolic motion dynamics of the left ventricular wall in normal subjects: Vector analysis of the wall motion velocities using pulsed tissue Doppler imaging.,
Journal of the American Society of Echocardiography, Vol.10, 408, 1997. Tomotsugu Tabata, T Oki, Hirotsugu Yamada, K Manabe, K Fukuda, M Abe, A Iuchi, N Fukuda and Susumu Ito :
Evaluation of left ventricular regional systolic wall motion velocity in hypertrophied hearts using pulsed tissue Doppler imaging.,
Journal of the American Society of Echocardiography, Vol.10, 442, 1997. Tomotsugu Tabata, T Oki, Hirotsugu Yamada, K Manabe, K Fukuda, M Abe, A Iuchi, N Fukuda and Susumu Ito :
Evaluation of left atrial relaxation abnormality using pulmonary venous flow velocity and interatrial septal motion.,
Journal of the American Society of Echocardiography, Vol.10, 440, 1997. T Oki, Tomotsugu Tabata, Hirotsugu Yamada, K Manabe, K Fukuda, M Abe, A Iuchi, N Fukuda and Susumu Ito :
Evaluation of electrical and mechanical discordance during atrial systole using pulsed tissue Doppler imaging.,
Journal of the American Society of Echocardiography, Vol.10, 412, 1997. T Oki, Tomotsugu Tabata, Hirotsugu Yamada, Tetsuzo Wakatsuki, H Shinohara, Akiyoshi Nishikado, A Iuchi, N Fukuda and Susumu Ito :
Clinical application of pulsed Doppler tissue imaging for assessing abnormal relaxation of the left ventricle.,
Circulation, Vol.94, I-565, 1996. Tomotsugu Tabata, Takashi Oki, Hirotsugu Yamada, Arata Iuchi, Takaki Hori, Tetsuya Kitagawa, Itsuo Kato, Hiroshi Kitahata, Shuzo Oshita and Susumu Ito :
Roles of left atrial appendage for left atrial hemodynamics by left atrial appendage clamping during cardiac surgery.,
Circulation, Vol.94, I-252, 1996. Hirotsugu Yamada, T Oki, Tomotsugu Tabata, K Manabe, K Fukuda, M Abe, A Iuchi, Akiyoshi Nishikado, Tetsuzo Wakatsuki, K Sakabe, J Ikata and Susumu Ito :
Assessment of myocardial circumferential shortening of the left ventricular wall using pulsed Doppler tissue imaging.,
Circulation, Vol.94, I-132, 1996. T Oki, A Iuchi, Tomotsugu Tabata, Hirotsugu Yamada, Akiyoshi Nishikado, Tetsuzo Wakatsuki, H Shinohara, N Fukuda and Susumu Ito :
Non-invasive assessment of left ventricular relaxation by pulsed Doppler tissue imaging: comparison with cardiac catheterization.,
Euro Heart J, 1996. Tomotsugu Tabata, T Oki, A Iuchi, Hirotsugu Yamada, K Manabe, K Fukuda, M Sasaki, N Fukuda and Susumu Ito :
Evaluation of left ventricular diastolic function in hypertrophied hearts using Doppler tissue imaging.,
Euro Heart J, 1996. Tomotsugu Tabata, T Oki, A Iuchi, Hirotsugu Yamada, K Manabe, M Sasaki, K Kawahara, T Niki, N Fukuda and Susumu Ito :
Evalution of left ventricular diastolic function in hypertrophied hearts using Doppler tissue imaging.,
Journal of the American Society of Echocardiography, Vol.9, 379, 1996. K Sakabe, Tetsuzo Wakatsuki, H Shinohara, Akiyoshi Nishikado, Hirotsugu Yamada, Tomotsugu Tabata, A Iuchi, T Oki and Susumu Ito :
Coronary flow velocity immediately after reperfusion reflects myocardial microcirculation in canine acute myocardial infarction models.,
Journal of the American College of Cardiology, Vol.27, 405A, 1996. Tomotsugu Tabata, T Oki, A Iuchi, K Manabe, M Sasaki, Hirotsugu Yamada, N Fukuda and Susumu Ito :
Influence of left atrial pressure on the left atrial appendage flow velocity pattern.,
Journal of the American College of Cardiology, Vol.27, 1996. N Fukuda, T Oki, A Iuchi, Tomotsugu Tabata, K Manabe, Y Kageji, M Sasaki, Hirotsugu Yamada and Susumu Ito :
Effect of left atrial pressure on the rate of left ventricular relaxation estimated by mitral regurgitant flow velocity using continuous wave Doppler echocardiography in dilated heart.,
Eur Heart J, Vol.16, 511, 1995. M Sasaki, T Oki, A Iuchi, Tomotsugu Tabata, Y Kageji, K Manabe, Hirotsugu Yamada, N Fukuda and Susumu Ito :
Transesophageal pulsed Doppler echocardiographic evaluation of left atrial systolic performance in hypertrophic cardiomyopathy.,
Eur Heart J, Vol.16, 305, 1995. Tomotsugu Tabata, T Oki, N Fukuda, A Iuchi, K Manabe, Y Kageji, M Sasaki, Hirotsugu Yamada and Susumu Ito :
Influence of ageing on left atrial appendage flow velocity pattern in healthy subjects with sinus rhythm: a study with transesophageal pulsed Doppler echocardiography.,
Eur Heart J, Vol.16, 304, 1995. Tomotsugu Tabata, T Oki, N Fukuda, A Iuchi, K Manabe, Y Kageji, M Sasaki, Hirotsugu Yamada and Susumu Ito :
Influence of left atrial pressure on the left atrial appendage flow velocity pattern in myocardial diseases with sinus rhythm.,
Eur Heart J, Vol.16, 98, 1995. Kenya Kusunose, Hirotsugu Yamada, Yoshihito Saijo, Susumu Nishio, Yukina Hirata, Takayuki Ise, Koji Yamaguchi, Daiju Fukuda, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Preload Stress Echocardiography for the Assessment of Heart Failure With Preserved Ejection Fraction,
JACC. Cardiovascular Imaging, Vol.15, No.2, 375-378, 2022.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jcmg.2021.09.005
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34656477; ● Summary page in Scopus @ Elsevier: 2-s2.0-85123584116

(DOI: 10.1016/j.jcmg.2021.09.005, PubMed: 34656477, Elsevier: Scopus) Kenya Kusunose, K Matsunaga, Hirotsugu Yamada and Masataka Sata :
Identifying the extent of oral fluid droplets on echocardiographic machine consoles in COVID-19 era,
Journal of Echocardiography, Vol.18, No.4, 268-270, 2020.

(キーワード): COVID-19 / Echocardiography / Equipment Contamination / Fomites / Humans / Infection Control / Language / Masks / Saliva / Speech
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s12574-020-00491-9
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32946008; ● Search Scopus @ Elsevier (PMID): 32946008; ● Search Scopus @ Elsevier (DOI): 10.1007/s12574-020-00491-9

(DOI: 10.1007/s12574-020-00491-9, PubMed: 32946008) 水関清, 亀田徹, 小林英夫, 山田博胤, 谷口信行 :
亀田徹氏らによる「Bラインを用いたpoint-of-care超音波による心原性肺水腫の評価」 (超音波医学 2018 ; 45 : 1252-135)を拝読して / 水関清氏の論評に対する回答,
超音波医学, Vol.45, No.5, 509-510, 2018年.

(出版サイトへのリンク): ● Publication site (DOI): 10.3179/jjmu.jjmu.a.114
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.3179/jjmu.jjmu.a.114

(DOI: 10.3179/jjmu.jjmu.a.114) Kenya Kusunose, Hirotsugu Yamada, Rino Suzukawa, Yukina Hirata, Masami Yamao, Takayuki Ise, Shusuke Yagi, Masashi Akaike and Masataka Sata :
Effects of Transthoracic Echocardiographic Simulator Training on Performance and Satisfaction in Medical Students.,
Journal of the American Society of Echocardiography, Vol.29, No.4, 375-377, 2016.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.echo.2015.12.002
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26743736; ● Summary page in Scopus @ Elsevier: 2-s2.0-84960912424

(DOI: 10.1016/j.echo.2015.12.002, PubMed: 26743736, Elsevier: Scopus)

総説・解説

山田博胤, 楠瀬賢也, 杉本匡史 :
EuroEcho - Imaging 2018,
心エコー, Vol.20, No.4, 436-439, 2019年4月. 山田博胤 :
こういうエコーマインド・エコー技術を学んでほしい,
心エコー, Vol.20, No.1, 102-105, 2019年. 西條良仁, 山田博胤 :
【聴診・触診×エコーで診断推論!-Point-of-Care超音波(POCUS)の底力】心音・心雑音とエコーエコーの前に聴診を!,
総合診療, Vol.28, No.6, 778-785, 2018年6月. 山田博胤 :
【診断と治療のABC[134]心房細動】 (第2章)病態生理心房細動の血行動態,
最新医学, 58-64, 2018年5月. 亀田徹, 小林英夫, 山田博胤, 谷口信行 :
Bラインを用いたpoint-of-care超音波による心原性肺水腫の評価,
超音波医学, Vol.45, No.2, 125-135, 2018年3月.

(キーワード): 姿勢
(出版サイトへのリンク): ● Publication site (DOI): 10.3179/jjmu.JJMU.A.106
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.3179/jjmu.JJMU.A.106

(DOI: 10.3179/jjmu.JJMU.A.106) Masao Daimon, Makoto Akaishi, Toshihiko Asanuma, Shuji Hashimoto, Chisato Izumi, Shiro Iwanaga, Hiroya Kawai, Hiroyuki Toide, Akihiro Hayashida, Hirotsugu Yamada, Mitsushige Murata, Yutaka Hirano, Kengo Suzuki and Satoshi Nakatani :
Guideline from Japanese Society of Echocardiography: 2018 focused update incorporated into Guidance for the Management and Maintenance of Echocardiography Equipment.,
Journal of Echocardiography, Vol.16, No.1, 1-5, Jan. 2018.

(要約): Echocardiography plays a pivotal role as an imaging modality in the modern cardiology practice. Information derived from echocardiography is definitely helpful for a patient care. The Japanese Society of Echocardiography has promoted echocardiography for a routine clinical and research use. One of the missions of the Society is to provide information that is useful for high-quality examinations. To ensure it, we believe equipment in good conditions and a comfortable environment are important for both a patient and an examiner. Thus, the Committee for Guideline Writing, the Japanese Society of Echocardiography published brief guidance for the routine use of echocardiography equipment in 2015. Recently, the importance of international standardization has been emphasized in the medical laboratories. Accordingly, the committee has revised and updated our guidance for the routine use of echocardiography equipment.
(徳島大学機関リポジトリ): ● Metadata: 115509
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s12574-018-0370-z
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29362979; ● Search Scopus @ Elsevier (PMID): 29362979; ● Search Scopus @ Elsevier (DOI): 10.1007/s12574-018-0370-z

(徳島大学機関リポジトリ: 115509, DOI: 10.1007/s12574-018-0370-z, PubMed: 29362979) 楠瀬賢也, 山田博胤 :
【右心不全を考える】診る心エコーによる右室機能評価法はどこまで進んでいるか,
Heart View, Vol.22, No.1, 10-17, 2018年1月.

(キーワード): *右心室機能

山田博胤 :
心エコー法・ドプラ法 (3) 右心機能,
日本臨牀, Vol.76, No.9, 547-552, 2018年. Yuta Torii, Kenya Kusunose, Hirotsugu Yamada, Y Saijo, Hiromitsu Seno, Susumu Nishio, Yukina Hirata and Masataka Sata :
Pre-Discharge LV Filling Pressure and Pulmonary Artery Pressure Were Associated With Hospital Readmission in Heart Failure With Reduced and Preserved Ejection Fraction,
AHA Scientific Sessions2017, Nov. 2017. 山田博胤 :
【糖尿病診療における心血管合併症の診かたup to date】糖尿病患者における周術期心機能評価とマネジメント循環器内科医の立場から,
月刊糖尿病, Vol.8, No.7, 82-88, 2017年7月. 平田有紀奈, 山田博胤, 佐田政隆 :
【循環器疾患と異所性脂肪】心外膜下脂肪を測定する意義,
Cardiac Practice, Vol.27, No.4, 279-284, 2016年11月. 天野里エ, 山田博胤 :
【ドプラ法における匠の技】 <応用編>ドプラ法を駆使した臨床診断心筋症診断でドプラ法をいかに利用するか,
心エコー, Vol.17, No.11, 998-1007, 2016年11月. 西條良仁, 山田博胤 :
【肺高血圧症の最新知見と新展開】肺高血圧症における非侵襲的検査としての超音波診断の有用性,
血管医学, Vol.17, No.3, 281-290, 2016年10月.

(キーワード): 肺高血圧 / 三次元心エコー図法 / 心エコー図検査 / 運動誘発性肺高血圧 / Speckletracking法
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1520573331119018752

(CiNii: 1520573331119018752) 山田博胤 :
糖尿病患者における周術期心機能評価とマネジメント:循環器内科医の立場から,
月刊糖尿病, Vol.8, No.7, 82-88, 2016年7月. 平田有紀奈, 山田博胤 :
左室拡張能評価におけるわたしの工夫 - 迷った時にはどうするか?,
心エコー, Vol.17, No.7, 590-597, 2016年7月. 鳥居裕太, 山田博胤 :
血管領域の最新動向,
インナービジョン, Vol.31, No.3, 29-32, 2016年3月. 鳥居裕太, 山田博胤 :
【US Today 2016 ジャンル別超音波最新動向先進技術の活用法も含めて】ジャンル別超音波最新動向血管領域の最新動向,
INNERVISION, Vol.31, No.3, 29-32, 2016年2月. 増山理, 豊田茂, 山田博胤, 鈴木聡 :
肺うっ血と体うっ血 : 病態, 診断から治療まで,
Fluid Management Renaissance, Vol.6, No.1, 7-13, 2016年2月.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1520010381228363136

(CiNii: 1520010381228363136) 山田博胤, 西條良仁 :
【体うっ血の評価】前負荷と心機能指標,
Fluid Management Renaissance, Vol.6, No.1, 30-35, 2016年2月.

(キーワード): 前負荷 / Frank-Starling機序 / 心エコー・ドプラ法 / 左室拡張末期圧 / 下肢陽圧負荷
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1520010381227955072

(CiNii: 1520010381227955072) 山田博胤 :
今年はこうして心エコー技術を学ぶこうして始まったこの講習会エコー淡路編心エコーと血管エコーのコラボレーションを目指して,
心エコー, Vol.17, No.1, 66-71, 2016年1月. 山田博胤 :
こうして始まったこの講習会 - エコー淡路編~心エコーと血管エコーのコラボレーションを目指して~,
心エコー, Vol.17, No.1, 66-71, 2016年1月. Kenya Kusunose and Hirotsugu Yamada :
Rest and exercise echocardiography for early detection of pulmonary hypertension,
Journal of Echocardiography, Vol.14, No.1, 2-12, Nov. 2015.

(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s12574-015-0268-y
(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-84960805698

(DOI: 10.1007/s12574-015-0268-y, Elsevier: Scopus) 坂東美佳, 山田博胤 :
肥大型心筋症治療戦略構築のための評価ポイント,
心エコー, Vol.16, No.10, 1024-1031, 2015年10月. 楠瀬賢也, 山田博胤 :
肺高血圧症の臨床と運動負荷心エコー法,
心エコー, Vol.16, No.7, 736-739, 2015年7月. 鳥居裕太, 山田博胤 :
感染性心内膜炎の診断日常検査としての心エコー,
臨床検査, Vol.59, No.6, 514-523, 2015年6月. 山田博胤, 坂東美佳, 西尾進, 天野里江, 鳥居裕太, 山口浩司, 若槻哲三, 佐田政隆 :
超音波後方散乱信号を用いた頸動脈プラークの性状診断とその臨床応用,
Neurosonology, Vol.28, No.suppl-1, 94, 2015年5月. 坂東美佳, 山田博胤 :
人工弁置換術後は何を評価するか,
心エコー, Vol.16, No.4, 403-411, 2015年4月. 西尾進, 山田博胤 :
粘液腫,
心エコー, Vol.16, No.2, 108-116, 2015年2月. 伊勢孝之, 高木恵理, 岩瀬俊, 楠瀬賢也, 山口浩司, 八木秀介, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
心臓サルコイドーシス再燃に対してメトトレキサートの併用が有効であった1例,
日本内科学会雑誌, Vol.104, No.6, 1175-1179, 2015年.

(要約): 心臓サルコイドーシスの標準的治療はステロイドであるが，ステロイドを投与中であっても再燃を認めることも多く，またステロイドの多岐にわたる副作用も問題となることが多い．症例は70歳代，女性．心臓サルコイドーシスの診断でプレドニンを維持量5 mg/日で加療されていた．定期検査で施行した心電図で陰性T波，前壁心尖部に新規の左室壁運動異常を認めた．FDG-PET，Gaシンチグラフィーで壁運動異常部位に一致して集積を認め，心臓サルコイドーシスの再燃と判断した．本症例では，ステロイドの副作用として糖尿病，肥満，白内障などを認めており，ステロイド増量が躊躇され，メトトレキサートの併用を開始した．メトトレキサート開始後，特に副作用を認めず，心電図ならびに左室壁運動異常の改善が認められた．ステロイド投与で再燃を認める心臓サルコイドーシス症例にはメトトレキサート併用も考慮すべきであると考えられた．
(キーワード): 心臓サルコイドーシス / 再燃 / ステロイド (steroid) / メトトレキサート / 副作用
(出版サイトへのリンク): ● Publication site (DOI): 10.2169/naika.104.1175
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390001206449318272; ● Search Scopus @ Elsevier (DOI): 10.2169/naika.104.1175

(DOI: 10.2169/naika.104.1175, CiNii: 1390001206449318272) 楠瀬賢也, 山田博胤 :
肺高血圧症の臨床と運動負荷心エコー法,
心エコー, Vol.16, No.7, 736-739, 2015年. 鳥居裕太, 山田博胤 :
感染性心内膜炎の診断．日常検査としての心エコー．,
臨床検査, Vol.59, No.6, 514-523, 2015年. 西尾進, 山田博胤 :
粘液腫,
心エコー, Vol.16, No.2, 108-116, 2015年. 坂東美佳, 山田博胤 :
人工弁置換術後は何を評価するか,
心エコー, Vol.16, No.4, 403-411, 2015年. 今田久美子, 八木秀介, 山口浩司, 若槻哲三, 伊勢孝之, 太田理絵, 門田宗之, 高島啓, 松浦朋美, 飛梅威, 岩瀬俊, 山田博胤, 添木武, 赤池雅史, 佐田政隆 :
心不全を合併した腎血管性高血圧に対する経皮的腎動脈形成術の有効性(第11回若手奨励賞受賞論文),
四国医学雑誌, Vol.70, No.3, 4, 87-92, 2014年8月.

(要約): 【Background】 Percutaneous transluminal renal angioplasty (PTRA) is recommended for patients with heart failure due to renovascular hypertension ; however, the clinical characteristics of the patients and the effects of PTRA on heart failure and cardiorenal function have not been elucidated. 【Methods】 We retrospectively analyzed data for 4 PTRA-treated patients (male/female, 1/3 ; mean age, 70.0±10 years ; mean left ventricular ejection fraction, 51.5±15.2%) with heart failure due to renovascular hypertension and evaluated the effects of PTRA on heart failure and cardiorenal function 6 months after treatment. 【Results】 All patients had pro-arteriosclerotic diseases including diabetes mellitus, essential thrombocythemia, heparin cofactor II deficency, metabolic syndrome, and familial hypercholesterolemia, and 3 patients had ischemic heart disease. No abdominal bruit was heard and mean plasma renin activity was 4.5±3.6 ng/ml/hr, which was not elevated, contrary to expectation. All contralateral kidneys of PTRA were nonfunctioning, suggesting bilateral kidneys were disturbed in all patients. In all patients, PTRA was successfully performed and resolved heart failure. PTRA resulted in decreases in systolic blood pressure from 157±18 to 124±8.6 mmHg, mean serum creatinine from 3.2±2.6 to 2.7±2.2 mg/dl, and mean BNP from 919±998 to 243±291 pg/ml at 6 months after treatment. PTRA did not change left ventricular ejection fraction, a parameter of systolic fraction evaluated by an echocardiogram ; however, PTRA improved E/e', a parameter of left ventricular diastolic fraction, from 16.1±5.2 to 9.7±3.7. None of the patients were hospitalized due to heart failure during the 6-month period after PTRA. 【Conclusions】 Patients with heart failure with cardiovascular risk factors should be screened for renovascular hypertension regardless of abdominal bruit or plasma renin activity. PTRA is effective for resolving heart failure and for improving renal and cardiac diastolic functions in patients with renovascular hypertension complicated with heart failure.
(キーワード): 心不全 (heart failure) / cardiac disturbance syndrome / percutaneous transluminal renal angioplasty
(徳島大学機関リポジトリ): ● Metadata: 109759
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1010000782245831073

(徳島大学機関リポジトリ: 109759, CiNii: 1010000782245831073) 楠瀬賢也, 山田博胤 :
拡張型心筋症(DCM),
心エコー, Vol.12, No.15, 1156-1162, 2014年. 西尾進, 山田博胤 :
正しいドプラ計測をマスターする左心系,
心エコー, Vol.15, No.2, 178-182, 2014年. 西尾進, 山田博胤, 佐田政隆 :
頸動脈エコー検査による頸動脈内膜中膜複合体肥厚度(IMT)の評価,
Cardio-Renal Diabetes, Vol.2, No.4, 4-7, 2013年11月.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1521136281138006656

(CiNii: 1521136281138006656) 楠瀬賢也, 山田博胤 :
心不全の診断における心エコー図検査の役割(特集心不全診療に心エコー図検査を活かす),
循環器内科, Vol.73, No.2, 110-117, 2013年2月.

(キーワード): heart failure / echocardiography / diastolic function / diagnosis / prognosis
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1522825130327206016

(CiNii: 1522825130327206016) 山田博胤, 坂東美佳 :
診断のテクニックが必ずアップする心エコー講座緊急カテだ!その前に⋯:急性冠症候群の緊急対応における心エコー検査,
Circulation up-to-date, Vol.8, No.6, 707-717, 2013年. 山田博胤, 小谷敦志 :
秘伝のハンズオンセミナー誌上実況中継心エコーで血管をみる，血管エコーで心臓をみる,
バスキュラー・ラボ, Vol.10, No.6, 48-72, 2013年. 發知淳子, 山田博胤 :
心機能評価ー収縮能・拡張能評価,
心エコー, Vol.14, No.11, 1046-1053, 2013年. 山田博胤, 西尾進, 佐田政隆 :
血管機能不全(後編)血管弾性,
Vascular Lab, Vol.10, No.4, 452-456, 2013年. 楠瀬賢也, 山田博胤 :
感染性心内膜炎のエコーレポート-診断と今後の方針を意識する,
心エコー, Vol.14, No.6, 594-601, 2013年. 西尾進, 山田博胤, 佐田政隆 :
血管機能不全(前編)血管内皮機能検査,
Vascular Lab, Vol.10, No.3, 343-347, 2013年. 冨田紀子, 山田博胤 :
心エコー法による左室拡張能の評価,
心臓, Vol.45, No.7, 753-760, 2013年. 山田博胤, 大木崇 :
特集:慢性心不全:診断と治療の進歩 Ⅱ．診断の進歩 3．心臓超音波検査,
日本内科学会雑誌, Vol.101, No.2, 354-361, 2012年2月.

(要約): 慢性心不全の診断，治療効果の判定，および経過観察に心臓超音波検査は欠かすことのできない手段である．臨床症状から心不全を疑った場合，まず左室駆出率(ejection fraction:EF)を評価し，EFの低下を認める場合にはドプラ法により拡張機能を評価し，心不全の診断および重症度評価を行う．一方，EFが保たれている場合には，各種器質的心疾患を除外した上で拡張機能を評価し，"EFが保持された心不全"として診断される．
(キーワード): 左室駆出率 / 拡張機能 / ドプラ法
(出版サイトへのリンク): ● Publication site (DOI): 10.2169/naika.101.354
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22523803; ● CiNii @ 国立情報学研究所 (CRID): 1390282681423670656; ● Search Scopus @ Elsevier (PMID): 22523803; ● Search Scopus @ Elsevier (DOI): 10.2169/naika.101.354

(DOI: 10.2169/naika.101.354, PubMed: 22523803, CiNii: 1390282681423670656) 山田博胤, 玉井利奈 :
麻酔科医に知ってほしい経胸壁心エコー法による心機能評価,
日本臨床麻酔学会誌, Vol.32, No.1, 1-7, 2012年1月.

(キーワード): 経胸壁心エコー検査(TTE) / 術前検査 / 非心臓手術 / 心機能
(出版サイトへのリンク): ● Publication site (DOI): 10.2199/jjsca.32.001
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390282679734901248; ● Search Scopus @ Elsevier (DOI): 10.2199/jjsca.32.001

(DOI: 10.2199/jjsca.32.001, CiNii: 1390282679734901248) 西尾進, 山田博胤 :
心機能評価,
Medical Technology, Vol.40, No.2, 169-179, 2012年. 平田有紀奈, 山田博胤 :
心機能その2∼左心機能(拡張機能)∼,
Vascular lab, Vol.2, 66-72, 2012年. 弘田大智, 山田博胤 :
心機能その1∼左心機能(収縮機能)∼,
Vascular lab, Vol.1, 85-88, 2012年. 林修司, 山田博胤 :
パルスドプラ法で解析するもの,
心エコー, Vol.13, No.10, 948-957, 2012年. 楠瀬賢也, 山田博胤 :
心臓弁膜症に3次元心エコー法をどう活用すべきか?,
心エコー, Vol.13, No.7, 680-687, 2012年. 發知淳子, 山田博胤 :
心不全の診断・病態評価における心エコーの役割その症状，本当に心不全でいいんですか?,
心エコー, Vol.2, No.13, 100-107, 2012年. 西尾進, 山田博胤 :
胸痛にいかに対応するか,
臨床病理, Vol.59, No.12, 1099-1106, 2011年12月.

(キーワード): 胸痛 / 心エコー図検査 / 急性冠症候群 / 大動脈解離 / 肺塞栓
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22338912; ● CiNii @ 国立情報学研究所 (CRID): 1520290884527733888; ● Search Scopus @ Elsevier (PMID): 22338912

(PubMed: 22338912, CiNii: 1520290884527733888) 楠瀬賢也, 西尾進, 山田博胤 :
診断につながる血管検査の基本テクニック検査レポートとカルテ徹底比較心臓,
Vascular Lab, No.8, 229-250, 2011年8月. 楠瀬賢也, 山田博胤 :
心房細動で拡張機能は評価可能か?,
心エコー, No.12, 1156-1163, 2011年. 楠瀬賢也, 玉井利奈, 山田博胤 :
最短ルートで塞栓源をさがす!経胸壁心エコー,
Vascular Lab, No.8, 26-30, 2011年. 山田博胤, 楠瀬賢也, 西尾進, 添木武, 佐田政隆 :
循環器病診療における最新の診かた，考え方心房細動と塞栓症-何時，どのような治療を始めるか?-,
四国医学雑誌, Vol.66, No.3, 63-70, 2010年8月.

(要約): Atrial fibrillation(AF)is a common arrhythmia and the prevalence of this arrhythmia is increasing as aging. Secondary AF is defined as AF with organic heart disease and lone AF as AF without it. The AF is divided into paroxysmal, persistent and chronic by its onset and persistence. It is clinically important that any type AF causes thromboembolic stroke. The preventive Qumadin therapy should be applied to patients with AF. Transesophageal echocardiography has been utilized for the diagnosis of left atrial thrombus and for the prediction of stroke. CHADS2 score is a clinical prediction rule for estimating the risk of stroke in patients with non-rheumatic AF. Patients with CHADS2 score_1should be treated with Qumadin. Rhythm control and rate control are two different strategies for the treatment of AF. There is no evidence that indicate better choice between rhythm control and rate control. Recently, inhibitors of the renin-angiotensin system have a potential to prevent new onset of AF in patients who has risk factors.
(キーワード): atrial fibrillation / thrombosis / stroke / 経食道心エコー (transesophageal echocardiography) / qumadin
(徳島大学機関リポジトリ): ● Metadata: 110316
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1050583647830844160

(徳島大学機関リポジトリ: 110316, CiNii: 1050583647830844160) 山田博胤, 楠瀬賢也, 西尾進 :
僧帽弁口血流と僧帽弁輪運動速波形の撮り方・読み方,
心エコー, Vol.11, 24-34, 2010年. 楠瀬賢也, 山田博胤, 西尾進 :
弁膜症の評価を見直す-昔と何が変わったか- 大動脈弁疾患の手術適応,
心エコー, Vol.11, 422-429, 2010年. 楠瀬賢也, 山田博胤 :
Dual-Doppler Systemによる心房細動の左室拡張能評価,
Medix 日立インターメディックス, Vol.52, 23-26, 2010年. 山田博胤 :
経食道心エコー事始,
超音波検査技術, Vol.34, No.5, 616-617, 2009年. 楠瀬賢也, 山田博胤, 西尾進 :
弁疾患を評価する場合,
Vascular Lab, Vol.6, No.5, 488-495, 2009年. 楠瀬賢也, 山田博胤, 西尾進 :
心房細動例での心不全評価法,
心エコー, Vol.10, No.3, 232-238, 2009年. 楠瀬賢也, 山田博胤, 西尾進 :
右房を知る下大静脈の見方,
心エコー, Vol.10, No.10, 966-974, 2009年. 楠瀬賢也, 山田博胤 :
心房細動における血栓形成の一機序,
BRAIN RESCUE, Vol.19, 14-17, 2009年. 山田博胤 :
心エコー図検査室のあるべき姿―医師・ソノグラファーの役割―医師の役割ソノグラファーを育てるために医師は何をすべきか,
心エコー, Vol.10, No.5, 464-470, 2009年. 楠瀬賢也, 山田博胤, 西尾進 :
心エコー法を心不全の診断・治療に活かす心房細動例での心不全評価法,
心エコー, Vol.10, No.3, 232-238, 2009年. 西尾進, 山田博胤, 楠瀬賢也 :
左心耳,
心エコー, Vol.10, 34-38, 2009年. 山田博胤, 楠瀬賢也 :
心房細動と経食道心エコー-心筋スタニングについて,
脳と循環, Vol.13, 244-246, 2008年. 山田博胤 :
特別企画循環器科が必要とする画像診断とは携帯型超音波診断装置が変える循環器外来診療,
新医療, Vol.8, 163-166, 2008年. 山田博胤, 楠瀬賢也 :
僧帽弁口血流速波形,
心エコー, Vol.9, 382-395, 2008年. 山田博胤, 楠瀬賢也 :
Dual Doppler法を使った左室拡張能の評価,
Rad Fan, Vol.6, 98-101, 2008年. 山田博胤 :
心臓超音波検査の最新技術と臨床への応用-パルス組織ドプラ法の臨床応用-,
超音波検査技術, Vol.32, 342-343, 2007年. 河野裕美, 山田博胤 :
組織ドプラの意味,
心エコー, Vol.8, 812-823, 2007年. 西尾進, 山田博胤, 森一博 :
心室中隔欠損症,
Heart View, Vol.11, 225-227, 2007年. 西尾進, 山田博胤, 森一博 :
心房中隔欠損症,
Heart View, Vol.11, 222-224, 2007年. 楠瀬賢也, 山田博胤 :
Costrictionとtrestrictionの鑑別,
Heart View, Vol.11, 98-102, 2007年. 山田博胤, 楠瀬賢也 :
心房機能,
Heart View, Vol.11, 78-79, 2007年. 森一博, 早渕康信, 香美祥二, 山田博胤 :
2Dティッシュトラッキング法の小児科領域への応用,
Medix, Vol.46, 19-23, 2007年. 田畑智継, 山田博胤, 長野智章, 森修 :
2Dティッシュトラッキングの臨床応用,
Medix, Vol.43, 4-9, 2006年. 原田顕治, 山田博胤, 田畑智継 :
組織ドプラ法で是非計測すべき項目の意義と正常値,
心エコー, Vol.7, 586-598, 2005年. 山田博胤, 田畑智継 :
左心耳の診かた,
心エコー, Vol.4, 440-448, 2003年. 山田博胤, 大木崇, 福田信夫 :
心房細動治療の最前線心エコーの情報をどう役立てるか,
Heart View, Vol.5, 326-333, 2001年. 山田博胤, 大木崇 :
右心不全の測定と評価をどう治療に結びつけるか,
心エコー, Vol.3, 490-497, 2001年. 山田博胤, 大木崇 :
新しい手法を用いた局所壁運動異常の定量的評価,
心エコー, Vol.2, 234-241, 2001年. 山田博胤, 大木崇 :
組織ドプラ法-パルスTDI, カラーTDIの撮り方と測り方-,
心エコー, Vol.2, 4-17, 2001年. 大木崇, 山田博胤, 田中英治 :
循環器の画像診断ガイド疾患の画像診断高血圧症高血圧性心疾患,
綜合臨床, Vol.50, 1556-1562, 2001年. 大木崇, 山田博胤 :
心エコー・ドプラ法を用いた左室拡張機能の評価,
循環制御, Vol.22, 27, 2001年. 山田博胤, 大木崇 :
臨床医のための最新エコー法，エコー法の実践-心エコー法，心膜疾患,
Medicina, Vol.37, 208-212, 2000年. 山田博胤, 大木崇 :
心エコー・ドプラ法のNew Technology, 組織ドプラ法による左室心筋内速度計測,
Heart View, Vol.4, 1244-1251, 2000年. 井内新, 大木崇, 山田博胤, 小野瀬由紀子 :
【弁膜症の手術適応を考える】弁膜症の重症度と手術適応大動脈弁閉鎖不全症,
Heart View, Vol.4, 19-24, 2000年. 大木崇, 山田博胤, 小野瀬由紀子 :
【心機能評価の最近の進歩】心エコードプラ法による左室拡張機能評価,
循環器科, Vol.47, 357-365, 2000年. 山田博胤, 小野瀬由紀子, 大木崇 :
肺静脈血流パターンをどう読むか,
心エコー, Vol.1, 438-451, 2000年. 大木崇, 山田博胤 :
ドプラ組織イメージングとは,
心エコー, Vol.1, 184-190, 2000年. 大木崇, 田畑智継, 山田博胤, 小野瀬由紀子 :
大動脈弁逆流を知る．大動脈弁逆流の発生機序とその診断,
Heart View, Vol.1, 30-37, 1997年. 田畑智継, 山田博胤, 大木崇 :
心房中隔欠損症の画像診断,
検査と技術, Vol.25, 151-158, 1997年. 福田信夫, 大木崇, 井内新, 田畑智継, 山田博胤, 田村禎通 :
大動脈弁疾患の心エコー図と心機図所見,
検査と技術, Vol.23, 1077-1083, 1995年.

講演・発表

Natsumi Yamaguchi, TOMONORI Takahashi, Susumu Nishio, Robert Zheng, Yoshihito Saijyo, Muneyuki Kadota, Yutaka Kawabata, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Hirotsugu Yamada, Tetsuzo Wakatsuki and Masataka Sata :
Elevated left atrial stiffness index is a poor prognostic factor in heart failure with preserved ejection fraction undergoing transcatheter aortic valve replacement,
EUROECHO 2024, Dec. 2024. TOMONORI TAKAHASHI, Tetsuzo Wakatsuki, Ryo Bando, Yoshihito Saijo, Yutaka Kawabata, Rie Ueno, Tomomi Matsuura, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Association of Elevated Lipoprotein(a) Levels with Adverse Outcomes in Patients with Stable Angina Undergoing Stent-less PCI with Paclitaxel-coated Balloon,
AHA 2024, Chicago, Nov. 2024. Tezuka Kazuki, Takeshi Soeki, Tomoko Takahashi, Tomomi Matsuura, Akihiro Tani, Ryo Bando, R Zheng, TOMONORI Takahashi, Yoshihito Saijo, Tomoya Hara, Muneyuki Kadota, Yutaka Kawabata, Rie Ueno, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Hirotsugu Yamada, Tetsuzo Wakatsuki and Masataka Sata :
Risk Factors For Intraoperative Instability In Sedated Patients Undergoing Pulmonary Vein Isolation Ablation,
Sydney, Sep. 2024. Tomoko Takahashi, Takeshi Soeki, Tezuka Kazuki, TOMONORI Takahashi, Yoshihito Saijo, Tomoya Hara, Yutaka Kawabata, Muneyuki Kadota, Rie Ueno, Tomomi Matsuura, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Hirotsugu Yamada, Tetsuzo Wakatsuki and Masataka Sata :
NAFLD score predicts the onset of atrial fibrillation,
APHRS 2024, Sydney, Sep. 2024. Iwasaki Ren, Kusunose Kenya, Tanaka Hidekazu, Miyake Makoto, Moriuchi Kenji, Takeda Yasuharu, Hirotsugu Yamada and Akihiro Haga :
Left Ventricular Ejection Fraction Prediction: Preprocessing Network & Data Augmentation for Echocardiographic Standardization,
The 10th JKMP meeting at Nagoya, Sep. 2024. Yoshihito Saijo, Hirotsugu Yamada, Robert Zheng, TOMONORI Takahashi, Yutaka Kawabata, Rie Ueno, Muneyuki Kadota, Tomoya Hara, Tomomi Matsuura, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Differential echocardiographic profiles in immunoglobulin light chain and transthyretin amyloid cardiomyopathy: insights from speckle tracking analysis,
ESC 2024, London, Aug. 2024. R Bando, Tetsuzo Wakatsuki, Koji Yamaguchi, TOMONORI Takahashi, Takayuki Ise, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Clinical outcome of DCB vs DES for de novo large coronary lesion in HBR patients,
Euro PCR 2024, Paris, May 2024. Kohei Nagano, TOMONORI Takahashi, Tetsuzo Wakatsuki, Robert Zheng, Yoshihito Saijyo, Muneyuki Kadota, Yutaka Kawabata, Tomomi Matsuura, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Long-Term Outcome of Stentless Coronary Intervention With Drug-Coated Balloon in Patients With High Bleeding Risk,
AHA2023, Philadelphia, Nov. 2023. N Yamaguchi, Kenya Kusunose, Yukina Hirata, Susumu Nishio, TOMONORI Takahashi, Yoshihito Saijo, Muneyuki Kadota, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Improved Pressure-Flow Relationship With Sacubitril/Valsartan: A 6-min Walk Stress Echocardiographic Study,
AHA2023, Philadelphia, Nov. 2023. Y Okushi, Kenya Kusunose, Hiromitsu Seno, TOMONORI Takahashi, Yoshihito Saijyo, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
The Impact of Surveillance of Cancer Therapeutics-Related Cardiac Dysfunction by Periodic Echocardiography,
ASE2022, Seattle, Jun. 2022. Koji Yamaguchi, Tetsuzo Wakatsuki, Y Okushi, Kumiko Suto, Kazuhisa Matsumoto, Tomonori Takahashi, Muneyuki Kadota, Yutaka Kawabata, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Early and chronic phased local coagulative responses following bioresorbable-polymer drug-eluting stent implantation,
European Heart Journal, Vol.42, No.S1, ehab724.1245, Aug. 2021.

(出版サイトへのリンク): ● Publication site (DOI): 10.1093/eurheartj/ehab724.1245
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1093/eurheartj/ehab724.1245

(DOI: 10.1093/eurheartj/ehab724.1245) Yukina Hirata, Kenya Kusunose, Hirotsugu Yamada, T Tsuji, K Fujimori, J Kotoku and Masataka Sata :
Deep Learning For Detection Of Elevated Pulmonary Artery Wedge Pressure Using Standard Chest X-ray,
The Canadian Journal of Cardiology, Dallas, Nov. 2020.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.cjca.2021.02.007
(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-85108436549

(DOI: 10.1016/j.cjca.2021.02.007, Elsevier: Scopus) Miharu Arase, Kenya Kusunose, Sae Morita, N Yamaguchi, Yukina Hirata, Susumu Nishio, Takayuki Ise, Koji Yamaguchi, Daiju Fukuda, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Clinical Utility of Noninvasive Assessment of Flow-pressure Relationship in Scleroderma,
American Heart Associeition, Dallas, Nov. 2020. Y Okushi, Kenya Kusunose, Takayuki Ise, Takeshi Tobiume, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Differences ofCancer Types in Hospital Mortality in Patients With Venous Thromboembolism,
American Heart Association, Dallas, Nov. 2020.

(出版サイトへのリンク): ● Publication site (DOI): 10.1161/circ.142.suppl_3.13145
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1161/circ.142.suppl_3.13145

(DOI: 10.1161/circ.142.suppl_3.13145) Koji Yamaguchi, Tetsuzo Wakatsuki, Tomonori Takahashi, Muneyuki Kadota, Yutaka Kawabata, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Takeshi Tobiume, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Suppressed Local Coagulative Response After Newer-generation Ultrathin Strut SES Implantation Compared to Older-generation SES Implantation,
American Heart Association, Dallas, Nov. 2020.

(出版サイトへのリンク): ● Publication site (DOI): 10.1161/circ.142.suppl_3.12894
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1161/circ.142.suppl_3.12894

(DOI: 10.1161/circ.142.suppl_3.12894) Takeshi Soeki, Kazuhisa Matsumoto, Daiju Fukuda, E Uematsu, Tomomi Matsuura, Takeshi Tobiume, Kenya Kusunose, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Hirotsugu Yamada, Tetsuzo Wakatsuki and Masataka Sata :
Toll-like receptor 9 is a novel therapeutic target to prevent atrial fibrillation,
European Heart Journal, Vol.41, No.S2, ehaa946.0463, Aug. 2020.

(出版サイトへのリンク): ● Publication site (DOI): 10.1093/ehjci/ehaa946.0463
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1093/ehjci/ehaa946.0463

(DOI: 10.1093/ehjci/ehaa946.0463) Yukina Hirata, Kenya Kusunose, Natumi Yamaguchi, Sae Morita, Susumu Nishio, Yuichiro Okushi, Tomonori Takahashi, Hirotsugu Yamada, T Tsuji, K Fujimori, J Kotoku and Masataka Sata :
Deep learning for screening of pulmonary hypertension using standard chest X-Ray,
European Heart Journal, Amsterdam, Aug. 2020.

(出版サイトへのリンク): ● Publication site (DOI): 10.1093/ehjci/ehaa946.2246
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1093/ehjci/ehaa946.2246

(DOI: 10.1093/ehjci/ehaa946.2246) Natsumi Yamaguchi, Kenya Kusunose, S Haga, Sae Morita, Yukina Hirata, Yuta Torii, Susumu Nishio, Yuichiroh Ohkushi, Tomonori Takahashi, Hirotsugu Yamada, nao Yamada and Masataka Sata :
Assessment of left ventricular ejection fraction from echocardiographic images using machine learning algorithm,
Euro Echo 2019, Wien, Dec. 2019. Tomonori Takahashi, Kenya Kusunose, Shuji Hayashi, Sae Morita, Yuta Torii, Yukina Hirata, M Yamao, Susumu Nishio, Yuichiroh Ohkushi, M Abe, Hirotsugu Yamada, Tetsuzo Wakatsuki and Masataka Sata :
Updated prevalence of lambls excrescences using the latest three-dimensional tansesophageal echocardiography,
Euro Echo 2019, Wien, Dec. 2019. Kenya Kusunose, Nishio Susumu, Hirata Yukina, Takayuki Ise, Koji Yamaguchi, Daiju Fukuda, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Pulmonary Artery Hypertension Specific Therapy Improves Exercise Tolerance and Outcomes in Exercise-Induced Pulmonary Hypertension,
JACC. Cardiovascular Imaging, Vol.12, No.12, 2576-2579, Dec. 2019.

(キーワード): Adult / Aged / Antihypertensive Agents / Arterial Pressure / Disease Progression / Echocardiography, Stress / Exercise / Exercise Tolerance / Female / Humans / Male / Middle Aged / Progression-Free Survival / Prospective Studies / Pulmonary Arterial Hypertension / Pulmonary Artery / Recovery of Function / Time Factors / Vasodilator Agents / Walk Test
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jcmg.2019.07.002
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31422131; ● Search Scopus @ Elsevier (PMID): 31422131; ● Search Scopus @ Elsevier (DOI): 10.1016/j.jcmg.2019.07.002

(DOI: 10.1016/j.jcmg.2019.07.002, PubMed: 31422131) Yutaka Kawabata, Kenya Kusunose, Shusuke Yagi, Hirotsugu Yamada, Daiju Fukuda, Takeshi Soeki and Masataka Sata :
The relationship among local epicardial adipose tissue, coronary intraplaque microluminal structure, and coronary plaque formation -a fresh cadaveric study,
AHA2019, Philadelphia, Nov. 2019. Yukina Hirata, Masataka Sata, Kenya Kusunose, Hirotsugu Yamada, Yuta Torii, Susumu Nishio, nao Yamada, Koji Yamaguchi, Takeshi Soeki and Tetsuzo Wakatsuki :
Usefulness of echocardiographic epicardial adipose tissue thickness for predicting coronary artery disease regardless of body mass index,
AHA2019, Philadelphia, Nov. 2019. B Ganbaatar, Daiju Fukuda, Shusuke Yagi, Kenya Kusunose, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
S1p2 Receptor Antagonist Attenuates Endothelial Dysfunction And Inhibits Atherogenesis In Apolipoprotein-e-deficient Mice,
AHA2019, Philadelphia, Nov. 2019. Yuta Torii, Kenya Kusunose, Yukina Hirata, Hirotsugu Yamada and Masataka Sata :
Clinical utility of left atrial strain to predict functional recovery in patients with optimal treatments of heart failure,
AHA2019, Philadelphia, Nov. 2019. Kenya Kusunose, A Haga, T Abe, Daiju Fukuda, Hirotsugu Yamada and Masataka Sata :
Assessment of left ventricular ejection fraction from echocardiographic images using deep learning algorithm,
AHA2019, Philadelphia, Nov. 2019. Sutou Kumiko, Daiju Fukuda, B Ganbaatar, Shusuke Yagi, Kenya Kusunose, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Pemafibrate, a novel selective peroxisome proliferator-activated receptor-a modulator, ameliorated diabetes-induced endothelial dysfunction,
AHA2019, Philadelphia, Nov. 2019. A Kunduziayi, Daiju Fukuda, Shusuke Yagi, Kenya Kusunose, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Vildagliptin, a DPP-4 inhibitor, attenuates endothelial dysfunction and atherogenesis independent of its glucose lowering effect in apolipoprotein e-deficient mice,
AHA2019, Philadelphia, Nov. 2019. Byambasuren Ganbaatar, Daiju Fukuda, Shusuke Yagi, Kenya Kusunose, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Empagliflozin, a SGLT2 inhibitor, attenuates endothelial dysfuntion and atherogenesis by inhibiting inflammatory responses in the vasculature and adipose tissue in disbetic apolipoprotein E-deficient,
ESC Congress 2019, Paris, Sep. 2019. Takeshi Soeki, Kazuhisa Matsumoto, Daiju Fukuda, 植松悦子, Tomomi Matsuura, Takeshi Tobiume, Kenya Kusunose, Takayuki Ise, Koji Yamaguchi, Hirotsugu Yamada, Tetsuzo Wakatsuki and Masataka Sata :
Vildagliptin reduces inducitiligy of arterial fibrillation in hypertensive rats complicated with diabetes mellitus,
ESC Congress 2019, Paris, Sep. 2019. Koji Yamaguchi, Tetsuzo Wakatsuki, Rie Ueno, Yutaka Kawabata, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Takeshi Tobiume, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
The improvement of chronic local coagulative response according to the progress of drug eluting stent,
ESC Congress 2019, Paris, Sep. 2019. Maimaituxun Gulinu, Kenya Kusunose, Daiju Fukuda, Shusuke Yagi, Yuta Torii, Yukina Hirata, Susumu Nishio, nao Yamada, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Masataka Sata and Michio Shimabukuro :
Impact of epicardial adipose tissue on global longitudinal strain: a study in patients with normal left ventricular ejection fraction,
ESC Congress 2019, Paris, Sep. 2019. Maimaituxun Gulinu, Daiju Fukuda, Shusuke Yagi, Shoichiro Takao, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Masafumi Harada, Masataka Sata and Michio Shimabukuro :
Adipose tissue surrounding the kidney and its impact on coronary artery disease,
ESC Congress 2019, Paris, Sep. 2019. Rahadian Arief, Daiju Fukuda, Hotimah Masdan Salim, Shusuke Yagi, Kenya Kusunose, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Glycemic control with canagliflozin, a SGLT-2 inhibitor, attenuates atherosclerosis and endothelial dysfuntion in diabetic apolipoprotein e-deficient mice,
ESC Congress 2019, Paris, Aug. 2019. Phuong Tran Pham, D Fukuda, Shusuke Yagi, Kenya Kusunose, Hirotsugu Yamada, Takeshi Soeki, Michio Shimabukuro and Masataka Sata :
Rivaroxaban, a Direct Inhibitor of Factor Xa, Attenuates Endothelial Dysfunction in Streptozotocin-Induced Diabetic Mice Through the Inhibition of Protease-Activated Receptor 2 Signaling,
AHA, Chicago, Nov. 2018. Daiju Fukuda, Shusuke Yagi, Kenya Kusunose, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Inhibition of Thrombin-PARs Signaling by Dabigatran, a Direct Thrombin Inhibitor, Attenuates Endothelial Dysfunction in Diabetic Mice,
AHA, Chicago, Nov. 2018. Y Saijo, Kenya Kusunose, Hirotsugu Yamada, Susumu Nishio, Yuta Torii, Y Hirata, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Right Ventricular Contractile Function Predicts Cardiac Events in Passive and Reactive Pulmonary Hypertension,
AHA, Chicago, Nov. 2018. Kenya Kusunose, T Abe, A Haga, Hirotsugu Yamada, Daiju Fukuda, M Harada and Masataka Sata :
A Deep Learning Approach for Automated Diagnosis of Regional Wall Motion Abnormality on Echocardiography,
AHA, Chicago, Nov. 2018. Yukina Hirata, Kenya Kusunose, Hirotsugu Yamada, Susumu Nishio, O Harada, N Miyazato, A Haraguni, A Ito, Koji Yamaguchi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Epicardial Adipose Tissue Thickness Measured by Echocardiography is Useful Marker for Predicting Coronary Artery Disease,
AHA, Chicago, Nov. 2018. Takeshi Soeki, E Uematsu, Tomomi Matsuura, Takeshi Tobiume, Kenya Kusunose, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Tetsuzo Wakatsuki and Masataka Sata :
C-type natriuretic peptide improves left ventricular diastolic dysfunction and ischemia/reperfusion injury-associated ventricular arrhythmias.,
ESC2018, Munich, Aug. 2018. Hiroyuki Ito, Tetsuzo Wakatsuki, Koji Yamaguchi, Daiju Fukuda, Yutaka Kawabata, Takafumi Todoroki, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Takeshi Tobiume, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Growth of vasa vasorum is associated with local inflammation around coronary plaque in fresh cadavers,
ESC2018, Munich, Aug. 2018. Y Saijo, Kenya Kusunose, Mika Bando, H Seno, Robert Zheng, Susumu Nishio, Yukina Hirata, Y Tori, R Amano, Hirotsugu Yamada and Masataka Sata :
Localization of myocardial injury in anthracycline-induced cardiotoxicity: evaluation using two-dimensional speckle tracking echocardiography,
ESC2018, Munich, Aug. 2018. Maimaituxun Gulinu, Michio Shimabukuro, Daiju Fukuda, Shusuke Yagi, Hirata Yukina, Takashi Iwase, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Takeshi Tobiume, Koji Yamaguchi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Gender disparities of distribution of epicardial adipose tissue and its impact on coronary artery disease,
ESC2018, Munich, Aug. 2018. Susumu Nishio, K Kusunose, Yukina Hirata, Yuta Torii, R Amano, Y Saijo, Hirotsugu Yamada and Masataka Sata :
The effect of gender difference in patients with cardiovascular disease on various vascular functional indices.,
EACVI meeting 2018, Dec. 2017. M Bando, Hirotsugu Yamada, K Kusunose, Yukina Hirata, Junya Kuwahata, R Amano, Susumu Nishio and Masataka Sata :
Change in Ultrasonic Tissue Characteristics of Carotid Artery Plaque Reflects That of Coronary Artery Plaque,
EACVI meeting 2018, Dec. 2017. Junya Kuwahata, Y Saijo, Hirotsugu Yamada, Kenya Kusunose, Hiromitsu Seno, Y Okushi, Susumu Nishio, Yukina Hirata, Torii Yuta and Masataka Sata :
Detection of Subtle Changes in Stroke Volume during Pre-load Stress Echocardiography by Three-dimensional Echocardiography using Automated Adaptive Analytics Algorithm,
EACVI meeting 2018, Dec. 2017. Yukina Hirata, Kenya Kusunose, Hirotsugu Yamada, R Shimizu, Yuta Torii, Susumu Nishio, Y Okushi, Hiromitsu Seno, Y Saijo, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Quantitative Classification of Left Atrial Appendage is Superior to Visual Classification for Risk Stratification of Stroke in Atrial Fibrillation,
EACVI meeting 2018, Dec. 2017. Hirotsugu Yamada :
Right ventricular Arrithmogenic Cardiomyopathy,
Euro Echo 2017, Lisbon, Dec. 2017. J. Kuwahata, Y. Saijo, Hirotsugu Yamada, Kenya Kusunose, H. Seno, Y. Okushi, S. Nishio, Y. Hirata, Y. Torii, S. Morita and Masataka Sata :
Detection of subtle changes in stroke volume during pre-load stress echocardiography by three-dimensional echocardiography using automated adaptive analytics algorithm,
Euro Echo 2017, Portugal, Dec. 2017. Y. Hirata, Kenya Kusunose, Hirotsugu Yamada, J. Kuwahata, R. Shimizu, Y. Torii, R. Amano, M. Yamao, S. Nishio, H. Seno, Y. Saijo, Takeshi Soeki and Masataka Sata :
Association between left atrial appendage morphology and stroke in atrial fibrillation: comparison between quantitative and visual classification,
Euro Echo 2017, Portugal, Dec. 2017. Takeshi Soeki, Tomomi Matsuura, E Uematsu, Takeshi Tobiume, Kenya Kusunose, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Tetsuzo Wakatsuki and Masataka Sata :
Epicardial Adipose Tissue Produces Proinflammatory Cytokines and Influences the Pathogenesis of Atrial Fibrillation,
AHA Scientific Sessions2017, California, America, Nov. 2017. Yukina Hirata, Kenya Kusunose, Hirotsugu Yamada, J Kuwahata, Y Torii, S Nishio, H Seno, Y Saijo, Koji Yamaguchi, Tetsuzo Wakatsuki and Masataka Sata :
Detection of Coronary Artery Stenosis by Epicardial Adipose Tissue Thickness in Type 2 Diabetes,
AHA Scientific Sessions2017, California, America, Nov. 2017. Maimaituxun. Gulinu, Michio Shimabukuro, Y Hirata, Takashi Iwase, S Takao, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Takeshi Tobiume, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, M Harada and Masataka Sata :
Local Epicardial Adipose Tissue Thickness in Left Anterior Descending Artery Provides a New Prediction Model for Coronary Artery Disease,
AHA Scientific Sessions2017, California, America, Nov. 2017. Kenya Kusunose, Hirotsugu Yamada, S Nishio, Y Torii, Yukina Hirata, H Seno, Y Saijo, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Echocardiography Predicts Outcomes in Patients With Preserved Ejection Fraction and Low Gradient Aortic Stenosis,
AHA Scientific Sessions2017, California, America, Nov. 2017. Takeshi Soeki, Tomomi Matsuura, Daiju Fukuda, Etsuko Uematsu, Takeshi Tobiume, T Hara, Kenya Kusunose, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Hirotsugu Yamada, Tetsuzo Wakatsuki and Masataka Sata :
Activated Factor X Signaling Pathway via Protease-Activated Receptor-2 is a Novel Therapeutic Target to Prevent Atrial Fibrillation,
AHA Scientific Sessions2017, California, America, Nov. 2017. Koji Yamaguchi, Tetsuzo Wakatsuki, Yutaka Kawabata, H Ito, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Takeshi Tobiume, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Preserved Endothelial Function and Suppressed Local Coagulative and Inflammatory Response After Biodegradable Polymer SES Implantation Compared to Durable Polymer SES,
AHA Scientific Sessions2017, California, America, Nov. 2017. Tomomi Matsuura, Takeshi Tobiume, Takeshi Soeki, R Kato, M Hara, Kenya Kusunose, Koji Yamaguchi, Shusuke Yagi, Hirotsugu Yamada, Tetsuzo Wakatsuki and Masataka Sata :
Direct Slow Pathway Capture: A New Electrophysiological Method of Catheter Ablation for Atrioventricular Nodal Reentrant Tachycardia,
AHA Scientific Sessions2017, California, America, Nov. 2017. Susumu Nishio, Kenya Kusunose, Hirotsugu Yamada, Yukina Hirata, H Seno, Y Saijo, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Echocardiographic Epicardial Adipose Tissue Thickness is a Marker for the Detection of Vasospastic Angina,
ASE2017, Baltimore, Jun. 2017. Y Saijo, Hirotsugu Yamada, Kenya Kusunose, H Seno, Y Okushi, Susumu Nishio, Yukina Hirata, Y Torii and Masataka Sata :
Left Atrial Dysfunction in Patients with Infarction of Proximal Left Circumflex Artery,
ASE2017, Baltimore, Jun. 2017. Kenya Kusunose, Hirotsugu Yamada, Susumu Nishio, Y Hirata, Hiromitsu Seno, Y Saijo, Takayuki Ise, Koji Yamaguchi, Shuusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Right Ventricular Myocardial Strain during Preload Augmentation is Associated with Exercise Capacity,
ASE2017, Baltimore, Jun. 2017. Yukina Hirata, Hirotsugu Yamada, Kenya Kusunose, R Shimizu, Yuta Torii, Susumu Nishio, Hiromitsu Seno, Y Saijo, S Hayashi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Impact of Age on the Morphology of Left Atrial Appendage I Atrial Fibrillation,
AHA Scientific Sessions 2016, New Orleans, Nov. 2016. Y Torii, Hirotsugu Yamada, Kenya Kusunose, H Seno, Y Saijo, Y Okushi, S Nishio, Y Hirata, R Amano and Masataka Sata :
Effect of Direct Oral Anticoagulants on Carotid Artery Sclerosis in Patients with Atrial Fibrillation,
AHA Scientific Sessions 2016, New Orleans, Nov. 2016. H Seno, Hirotsugu Yamada, Kenya Kusunose, R Amano, M Matsushita, M Nanasato, T Murohara, H Kamiya and Masataka Sata :
Effect of Sitagliptin on Left Ventricular Function in Patients With Type 2 Diabetes a Sub Analysis of the PROLOGUE Study,
AHA Scientific Sessions 2016, New Orleans, Nov. 2016. Kenya Kusunose, Hirotsugu Yamada, Y Saijo, H Seno, Y Hirata, Y Torii, S Nishio, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Longitudinal Strain Distribution is a Powerful Predictor for Functional Recovery in Patients With Tachycardia-induced Cardiomyopathy,
AHA Scientific Sessions 2016, New Orleans, Nov. 2016. Kenya Kusunose, Hirotsugu Yamada, H Seno, Y Saijo, Takayuki Ise, Takeshi Tobiume, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Longitudinal Strain Distribution is a Powerful Predictor for Functional Recovery in Patients with Tachycardia-induced Cardiomyopathy,
KSC2016(The 60th Annual Scientific Meeting of The Korean Society of Cardiology), Seoul, Sep. 2016. Takeshi Soeki, Tomomi Matsuura, E Uematsu, S Bando, Takeshi Tobiume, Kenya Kusunose, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Increased local production of C-type natriuretic peptide in patients with vasospastic angina,
ESC Congress 2016, Rome, Aug. 2016. Koji Yamaguchi, Tetsuzo Wakatsuki, R Ueno, H Ito, Takayuki Ise, Tomomi Matsuura, Kenya Kusunose, Takeshi Tobiume, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Paclitaxel eluting balloon angioplasty equals everolimus eluting stent implantation in local coagulative and inflammatory responses in stable angina patients,
ESC Congress 2016, Rome, Aug. 2016. T Matsuura, Takeshi Soeki, E Uematsu, S Bando, Takeshi Tobiume, T Hara, Kenya Kusunose, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Oral Direct Factor Xa Inhibitor Prevents Atrial Fibrillation by Inhibiting Inflammation in Rapidly Paced Spontaneously Hypertensive Rats,
ESC Congress 2016, Rome, Aug. 2016. Y Saijo, Hirotsugu Yamada, Kenya Kusunose, H Seno, S Nishio, R Amano, Y Hirata and Masataka Sata :
Clinical Utility of Preload Stress Echocardiography for Predicting Future Pseudo-normal Transmitral Flow Pattern,
ASE2016, Seattle, Jun. 2016. Hirotsugu Yamada, Kenya Kusunose, Y Torii, Y Saijo, H Seno, Y Hirata, R Amano, S Nishio and Masataka Sata :
Criteria for Exercise-induced Pulmonary Hypertension Using 6-minute Walk Stress Echocardiography in Patients with Collagen Tissue Disease.,
ASE2016, Seattle, Jun. 2016. Y Saijo, Kenya Kusunose, Hirotsugu Yamada, S Nishio, R Amano, Y Hirata, H Seno and Masataka Sata :
Echocardiographic Predictors for Worsening of 6-minute Walk Distance in Patients with Connective Tissue Disease,
ASE2016, Seattle, Jun. 2016. R Amano, Hirotsugu Yamada, Mika Bando, R Tamai, Y Torii, S Nishio, H Seno, Kenya Kusunose and Masataka Sata :
Quantitative Ultrasound Evaluation of the Changes on Tissue Characteristics of Carotid Plaques by Lipid Lowering Therapy,
ASE2016, Seattle, Jun. 2016. Hirotsugu Yamada, Kenya Kusunose, Y Saijo, H Seno, S Nishio, Y Torii, Y Hirata, R Amano and Masataka Sata :
Echocardiographic Diagnosis of Exercise-induced Pulmonary Hypertension in Patients with Connective Tissue Diseases,
AAE 2016 (4th Annual Scientific Sessions of the Asian-Pacific Association of Echocardiography), Osaka, Apr. 2016. Y Saijo, Hirotsugu Yamada, Kenya Kusunose, H Seno, S Nishio, R Amano, Y Hirata, Y Torii and Masataka Sata :
Clinical Utility of Preload Stress Echocardiography for Predict Future Pseudo -normal Transmitral Flow Pattern in Patients with Various Cardiac Diseases,
AAE 2016 (4th Annual Scientific Sessions of the Asian-Pacific Association of Echocardiography), Osaka, Apr. 2016. H Seno, Kenya Kusunose, Hirotsugu Yamada, Y Saijo, S Nishio, Y Hirata, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Comparison of Right Ventricular Global Longitudinal Strain Between Vender-Dependent and Vender-Independent Two-Dimensional Speckle Tracking Software,
ACC Scientific Sessions 2016, Chicago, Apr. 2016. S Bando, Takeshi Soeki, Tomomi Matsuura, Takeshi Tobiume, Takayuki Ise, Kenya Kusunose, Koji Yamaguchi, Shusuke Yagi, Hirotsugu Yamada, Tetsuzo Wakatsuki and Masataka Sata :
Atrial Late Potentials and Atrial Substrate Remodeling in Patients With Atrial Fibrillation.,
AHA Scientific Sessions 2015, Orlando, Nov. 2015. Y Hirata, Hirotsugu Yamada, Kenya Kusunose, S Nishio, Mika Bando, Koji Yamaguchi, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Clinical Utility of Echocardiographic Epicardial Adipose Tissue Thickness Measured Using a High-frequency Linear Probe in Patients with Coronary Artery Disease.,
AHA Scientific Sessions 2015, Orlando, Nov. 2015. Takeshi Soeki, S Bando, Tomomi Matsuura, Takeshi Tobiume, E Uematsu, Kenya Kusunose, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Combination Of Clinical, Electrocardiographic and Echocardiographic Parameters Predict the Onset of Atrial Fibrillation.,
AHA Scientific Sessions 2015, Orlando, Nov. 2015. A Takashima, Daiju Fukuda, K Tanaka, Y Higashikuni, Y Hirata, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
N-3 Polyunsaturated Fatty Acids Inhibit Inflammatory Responses in Macrophages by the Reduction of Toll-like Receptor 4 Expression in Lipid Rafts, Leading to the Suppression of Atherogenesis in Apolipoprotein E Deficient Mice.,
AHA Scientific Sessions 2015, Orlando, Nov. 2015. T Hara, Daiju Fukuda, K Tanaka, Y Higashikuni, Y Hirata, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Hematopoietic Protease-activated Receptor-2 Plays a Critical Role in Vascular Inflammation and Atherosclerosis in ApoE-Deficient Mice.,
AHA Scientific Sessions 2015, Orlando, Nov. 2015. Kenya Kusunose, Hirotsugu Yamada, Mika Bando, S Nishio, Y Hirata, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Pressure-flow Relationship of Pulmonary Circulation Determines Six-minute Walk Distance in Connective Tissue Disease.,
AHA Scientific Sessions 2015, Orlando, Nov. 2015. Y Torii, Kenya Kusunose, Hirotsugu Yamada, Mika Bando, S Hayashi, S Nishio, M Yamao, R Amano, Y Hirata and Masataka Sata :
Impact of atrial fibrillation on tricuspid annular plane systolic excursion in patients without organic cardiovascular disease.,
ASE 2015, Boston, Jun. 2015. Kenya Kusunose, Hirotsugu Yamada, J Hotchi, Mika Bando, S Nishio, Y Hirata, Jun Kishi and Masataka Sata :
Prediction of future overt pulmonary hypertension by sixminute walk stress echocardiography in connective tissue disease.,
ASE 2015, Boston, Jun. 2015. Mika Bando, Hirotsugu Yamada, Junko Hotsuchi, S Hayashi, Y Saijo, Y Takagawa, N Sawada, S Nishio, Y Hirata and Masataka Sata :
Association of CHADS2 and CHA2DS2-VASc scores with left atrial appendage dysfunction in patients with atrial fibrillation.,
Euro Echo Imaging 2014, Wien, Dec. 2014. T Hayashi, S Yamada, M Nakabachi, H Iwano, M Sakakibara, K Okada, D Murai, H Nishino, Kenya Kusunose, K Watanabe, T Ishizu, K Wakami, Hirotsugu Yamada, K Dohi, Y Seo, N Ohte, T Mikami and H Tsutsui :
Comparison of Tissue Doppler-Derived and Speckle Tracking-Derived Parameters for the Estimation of Left Ventricular Filling Pressure: A Multicenter Study in Japan.,
AHA Scientific Sessions 2014, Nov. 2014. Koji Yamaguchi, Tetsuzo Wakatsuki, A Takashima, Mika Bando, S Bando, Tomomi Matsuura, Takayuki Ise, Junko Hotsuchi, Takeshi Tobiume, Shusuke Yagi, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Differential response of local coagulation after implantation of new generation drug-eluting stents compared with sirolimus-eluting stent.,
AHA Scientific Sessions 2014, Chicago, Nov. 2014. T Hara, D Fukuda, K Tanaka, Y Higashikuni, Y Hirata, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Rivaroxaban, a direct factor Xa inhibitor, attenuates neointima formation after mechanical vascular injury.,
AHA Scientific Sessions 2014, Chicago, Nov. 2014. H Yamazaki, Tetsuzo Wakatsuki, Koji Yamaguchi, K Imada, K Matsumoto, Y Takagawa, E Takagi, Y Saijo, T Hara, Y Saito, Mika Bando, A Takashima, S Bando, Tomomi Matsuura, Takayuki Ise, Junko Hotsuchi, Takeshi Tobiume, Shusuke Yagi, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Differential responses of local coagulation after implantation of second-generation drug-eluting stent compared with first-generation drug-eluting stents.,
AHA Scientific Sessions 2014, Chicago, Nov. 2014. S Nishio, Hirotsugu Yamada, M Yamano, Y Hirata, K Mori, S Matsuoka and Masataka Sata :
Echocardiographic screening for congenital heart disease in infants and preschool children: 12 years experience in a civic event for children care.,
ESC 2014, Barcelona, Aug. 2014. Tomomi Matsuura, Takeshi Soeki, E Uematsu, S Bando, Takeshi Tobiume, Daiju Fukuda, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
A renin inhibitor prevents atrial endocardial dysfunction in rapidly paced rats with streptozotocin-induced diabetes.,
ESC 2014, Barcelona, Aug. 2014. Takeshi Soeki, E Uematsu, S Bando, Tomomi Matsuura, Takeshi Tobiume, Daiju Fukuda, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Relationship between local production of microRNA-328 and atrial substrate remodeling in atrial fibrillation.,
ESC 2014, Barcelona, Aug. 2014. S Bando, Takeshi Soeki, Takeshi Tobiume, Tomomi Matsuura, E Uematsu, Daiju Fukuda, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Atrial late potentials and atrial substrate remodeling in patients with atrial fibrillation.,
ESC 2014, Barcelona, Aug. 2014. T Hara, Daiju Fukuda, K Tanaka, Y Higashikuni, Y Hirata, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, M Shimabukuro and Masataka Sata :
Rivaroxaban, a direct factor Xa inhibitor, attenuates neointima formation following vascular injury in the mouse through the inhibition of proliferative activation of vascular smooth muscle cells.,
ESC 2014, Barcelona, Aug. 2014. T Hara, Daiju Fukuda, K Tanaka, Y Higashikuni, Y Hirata, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, M Shimabukuro and Masataka Sata :
Rivaroxaban, a direct factor Xa inhibitor, attenuates plaque progression and destabilization in ApoE-deficient mice by inhibiting macrophage activation.,
ESC 2014, Barcelona, Aug. 2014. Hirotsugu Yamada, S Akiyama, Junko Hotsuchi, Mika Bando, Y Saijo, S Nishio, M Yamano, Y Torii, Y Hirata and Masataka Sata :
Relationships between 3-Dimensional and 2-Dimensional/Doppler Echocardiographic Variables for Evaluating Right Ventricular Systolic Function.,
ASE 2014, Portland, Jun. 2014. Junko Hotsuchi, Hirotsugu Yamada, Y Saijo, Mika Bando, S Hayashi, S Nishio, M Yamano, Y Torii, Y Hirata, R Amano, Takayuki Ise, Koji Yamaguchi, Takeshi Tobiume, Shusuke Yagi, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Serial Changes of Exercise Stress Echocardiographic Parameters in Patients with Connective Tissue Disease without Overt Pulmonary Hypertension.,
ASE 2014, Portland, Jun. 2014. Mika Bando, Hirotsugu Yamada, S Nishio, R Amano, Y Hirata, Junko Hotsuchi, Y Saijo, Koji Yamaguchi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Predicting Restenosis of Coronary Artery Stents by Ultrasound Tissue Characteristics of Carotid Artery Plaque.,
ASE 2014, Portland, Jun. 2014. Michio Shimabukuro, C Okawa, XF Lei, JR Kim-Kaneyama, Hirotsugu Yamada, Hirotsugu Kurobe, Daiju Fukuda, M Sato, Tetsuya Kitagawa and Masataka Sata :
Effects of ezetimibe on oxidized cholesterol components in epicardial fat and myocardium: a gas chromatography-mass spectrometry analysis.,
EAS 2014, Madrid, May 2014. Y Saijo, Hirotsugu Yamada, Junko Hotsuchi, S Nishio, S Hayashi, Mika Bando, Y Hirata, R Amano, Takayuki Ise, Shusuke Yagi, Koji Yamaguchi, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Right ventricular systolic dysfunction in patients with exercise-induced pulmonary hypertension associated with connective tissue disease.,
ACC 2014, Washington, D.C., Mar. 2014. Junko Hotsuchi, Hirotsugu Yamada, S Nishio, Mika Bando, S Hayashi, Y Hirata, R Amano, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Right ventricular dysfunction in patients with exercise-induced pulmonary hypertension associated with connective tissue disease : an assessment using tricuspid annular motion velocities.,
Euro Echo Imaging 2013, Istanbul, Dec. 2013. S Hayashi, Hirotsugu Yamada, Junko Hotsuchi, Mika Bando, Takayuki Ise, Koji Yamaguchi, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Noninvasively Obtained Augmentation Index is Not a Reliable Maker for Vascular Sclerosis in Elderly Subjects.,
American Heart Association AHA 2013, Dallas, Nov. 2013. T Hara, Daiju Fukuda, K Tanaka, Y Higashikuni, Y Hirata, Takayuki Ise, Takeshi Tobiume, Koji Yamaguchi, Shusuke Yagi, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Rivaroxaban, A Novel Oral Anticoagulant, Attenuates Plaque Progression in ApoE-Deficient Mice Through the Inhibition of Pro-Inflammatory Activation of Macrophages.,
American Heart Association AHA 2013, Dallas, Nov. 2013. Koji Yamaguchi, Takeshi Soeki, Tetsuzo Wakatsuki, Takayuki Ise, Takeshi Tobiume, Shusuke Yagi, Takashi Iwase, Hirotsugu Yamada and Masataka Sata :
Impact Of Indoxy1 Sulfate, A Uremic Toxin, On Non-culprit Coronary Plaque Composition Assessed By Integrated Backscatter Intravascular Ultrasound In Patients With Coronary Artery Disease.,
American Heart Association AHA 2013, Dallas, Nov. 2013. Koji Yamaguchi, Tetsuzo Wakatsuki, Takayuki Ise, Takeshi Tobiume, Shusuke Yagi, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Decreased Local Hypercoagulation after Implantation of Everolimus-Eluting and Zotarolimus-Eluting Stents Compared with Early-Generation Drug-Eluting Stents in patients with stable angina.,
American Heart Association AHA 2013, Dallas, Nov. 2013. Koji Yamaguchi, Tetsuzo Wakatsuki, Takayuki Ise, Takeshi Tobiume, Shusuke Yagi, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Time-dependent Changes Of Local Vascular Response And Angiographic Peri-stent Contrast Staining Up To Five Years After Zotarolimus-eluting, Sirolimus-eluting, And Bare Metal Stent Implantation.,
American Heart Association AHA 2013, Dallas, Nov. 2013. S Bando, Takeshi Soeki, T Matsuura, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro, Kenji Kangawa and Masataka Sata :
Plasma Brain Natriuretic Peptide (BNP) level is elevated in patients with cancer.,
ESC Congress 2013, Amsterdam, Aug. 2013. Takashi Iwase, Shoichiro Takao, Masashi Akaike, Takayuki Ise, Shusuke Yagi, Koji Yamaguchi, Hirotsugu Yamada, Yasuhiko Nishioka, Masafumi Harada and Masataka Sata :
Differentiation of left ventricular systolic dysfunction related to cardiac sarcoidosis and other heart diseases using contrast-enhanced cardiovascular magnetic resonance.,
ESC Congress 2013, Amsterdam, Aug. 2013. S Bando, Takeshi Soeki, E Uematsu, T Matsuura, Daiju Fukuda, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro, Kenji Kangawa and Masataka Sata :
Ghrelin ameliorates the progression of experimental autoimmune myocarditis.,
ESC Congress 2013, Amsterdam, Aug. 2013. Takeshi Soeki, S Bando, T Matsuura, E Uenmatsu, Koji Yamaguchi, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Electrophysiological correlation and prognostic impact of pentraxin 3 as a local inflammatory marker in atrial fibrillation.,
ESC Congress 2013, Amsterdam, Aug. 2013. Tetsuzo Wakatsuki, Koji Yamaguchi, Toshiyuki Niki, Yoshio Taketani, Takayuki Ise, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
The tissue characteristics of coronary plaque with microchannel structure assessed by optical coherence tomography associated with local inflammatory response.,
ESC Congress 2013, Amsterdam, Aug. 2013. Koji Yamaguchi, Tetsuzo Wakatsuki, Toshiyuki Niki, Yoshio Taketani, Takayuki Ise, Shusuke Yagi, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Differential responses of local coagulation after implantation of everolimus-eluting and zotarolimus-eluting stents compared with early-generation drug-eluting stents in patients with stable angina.,
ESC Congress 2013, Amsterdam, Aug. 2013. Takeshi Soeki, K Yamaguchi, S Bando, T Matsuura, E Uematsu, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Cardiospecific microRNA plasma levels are associated with coronary plaque vulnerability.,
ESC Congress 2013, Amsterdam, Aug. 2013. Y Hirata, Hirotsugu Yamada, S Nishio, Mika Bando, S Hayashi, Junko Hotsuchi, T Tomofuji, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Echocardiographic epicardial adipose tissue thickness in anterior interventricular groove is a marker for the presence and severity of coronary artery disease.,
ESC Congress 2013, Amsterdam, Aug. 2013. S Hayashi, Hirotsugu Yamada, Junko Hotsuchi, S Nishio, Mika Bando, Y Hirata and Masataka Sata :
Peak Systolic Mitral Annular Motion Velocity Reflects the Status of Ventricular-Arterial Coupling: A Clinical Study.,
ASE 2013, Minneapolis, Jun. 2013. S Hayashi, Hirotsugu Yamada, Junko Hotsuchi, S Nishio, Mika Bando, Y Hirata and Masataka Sata :
Assessment of Optimal Method for Analysing Left Atrial Strain using Speckle Tracking Imaging.,
ASE 2013, Minneapolis, Jun. 2013. M Nakagawa, Hirotsugu Yamada, S Nishio, S Hayashi, Junko Hotsuchi, Mika Bando, Y Hirata, T Tomofuji and Masataka Sata :
Clinical Significance of Mitral L-wave in Patients with Atrial Fibrillation and Preserved Ejection Fraction.,
ASE 2013, Minneapolis, Jun. 2013. Hirotsugu Yamada, S Nishio, S Hayashi, Junko Hotsuchi, Mika Bando, Y Hirata, T Tomofuji and Masataka Sata :
Effect of Aging and Gender on Tricuspid Annular Motion Velocities and Displacement.,
ASE 2013, Minneapolis, Jun. 2013. S Hayashi, Hirotsugu Yamada, S Nishio, N Tomita, J Hotchi, Mika Bando, Takayuki Ise, Toshiyuki Niki, Koji Yamaguchi, Shusuke Yagi, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Augmentation Index Measured by Tonometry Significantly Underestimates Atrial Stiffness in Ischemic Heart Disease in Japanese Population.,
第77回日本循環器学会学術集会, Yokohama, Mar. 2013. Mika Bando, Hirotsugu Yamada, Toshiyuki Niki, S Nishio, R Tamai, J Hotchi, Yoshio Taketani, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Change in Ultrasonic Tissue Characteristics of Carotid Artery Plaque Reflects That of Coronary Artery Plaque.,
American College of Cardiology (ACC) 2013 Scientific Sessions, San Francisco, Mar. 2013. Takayuki Ise, Shusuke Yagi, Takashi Iwase, Masashi Akaike, M Kadota, T Hara, S Bando, Toshiyuki Niki, J Hotchi, N Tomita, Koji Yamaguchi, Yoshio Taketani, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Acute Hemodynamic Effects of Adaptive Servo-Ventilation in Patients with Chronic Left Heart Failure.,
AHA Scientific Sessions 2012, ロサンゼルス, Nov. 2012. Koji Yamaguchi, Tetsuzo Wakatsuki, Takeshi Soeki, Toshiyuki Niki, Yoshio Taketani, H. Oeduka, Mika Bando, K. Ogasawara, S. Bando, J. Hotchi, Takayuki Ise, Takashi Iwase, Hirotsugu Yamada and Masataka Sata :
Telmisartan Reduces Coronary Plaque Vulnerability and Instent-neointimal Proliferation in Hypertensive Patients.,
AHA Scientific Sessions 2012, ロサンゼルス, Nov. 2012. Toshiyuki Niki, Tetsuzo Wakatsuki, Mika Bando, K. Ogasawara, S. Bando, T. Matsuura, J. Hotch, Koji Yamaguchi, Yoshio Taketani, Takashi Iwase, N. Tomita, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Effects of Additional Eicosapentaenoic Acid to Statin Therapy on Inflammatory Cytokines and the Tissue Characterization of Coronary Plaque Assessed by Integrated Backscatter Intravascular Ultrasound Systems.,
AHA Scientific Sessions 2012, Nov. 2012. A. Takashima, Takayuki Ise, Masashi Akaike, Yuka Ueda, Takashi Iwase, T. Hara, M. Kadota, R. Ohta, K. Ogasawara, Toshiyuki Niki, J. Hotchi, Koji Yamaguchi, Yoshio Taketani, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Cardiac Rehabilitation Reduces Levels of Oxidized LDL.,
AHA Scientific Sessions 2012, ロサンゼルス, Nov. 2012. S. Bando, Takeshi Soeki, E. Uematsu, T. Matsuura, M. Kadota, T. Hara, R. Ohta, Y. Kawabata, K. Ogasawara, Mika Bando, Toshiyuki Niki, Takayuki Ise, J. Hotchi, N. Tomita, Yuka Ueda, Koji Yamaguchi, Yoshio Taketani, Takashi Iwase, Daiju Fukuda, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Relationship Between Nlrp3 Inflammasome and Coronary Atherosclerosis.,
AHA Scientific Sessions 2012, ロサンゼルス, Nov. 2012. S. Kimura, Yuka Ueda, Takayuki Ise, Takashi Iwase, K. Maeda, K. Nishikawa, K. Ogasawara, Mika Bando, S. Bando, Toshiyuki Niki, J. Hotchi, Koji Yamaguchi, N. Tomita, Yoshio Taketani, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Effect of Cardiac Rehabilitation with Supervised Exercise Training on Urinary Albumin Excretion in Patients with Cardiovascular Disease.,
AHA Scientific Sessions 2012, ロサンゼルス, Nov. 2012. Takeshi Soeki, S. Bando, Toshiyuki Niki, Koji Yamaguchi, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Kenji Kangawa and Masataka Sata :
Ghrelin protects the heart against ischemia-induced arrhythmias by modulating autonomic nerve activity.,
ESC Congress 2012, Munich, Aug. 2012. Takeshi Soeki, M. Kitani, Hirotsugu Yamada, Tetsuzo Wakatsuki, T. Kawano, S. Orino, K. Kawano, A. Kakutani, S. Bando and Masataka Sata :
Renoprotective effect of cilnidipine via the antioxidant activity in hypertensive patients.,
ESC Congress 2012, Munich, Aug. 2012. M. Dagvasumberel, Michio Shimabukuro, Junji Ueno, T. Nishiuchi, Takeshi Soeki, Takashi Iwase, Shoichiro Takao, Hirotsugu Yamada, Tetsuya Kitagawa and Masataka Sata :
Gender disparities in the association of epicardial adipose tissue volume and coronary atherosclerosis: a 256-slice multidetector computed tomography study.,
ESC Congress 2012, Aug. 2012. Toshiyuki Niki, Tetsuzo Wakatsuki, Koji Yamaguchi, Yoshio Taketani, S Bando, Takayuki Ise, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
The tissue characteristics of coronary plaque with microchannel structure in patients with Coronary Artery Disease assessed by OCT and IB-IVUS.,
ESC Congress 2012, Munich, Aug. 2012. Hirotsugu Yamada :
Cardiomyopathy, Takotsubo Cardiomyopathy (variant).,
American Society of Echocardiography (ASE) 23rd Annual Scientific Sessions, Maryland, Jun. 2012. S Hayashi, Hirotsugu Yamada, N Tomita, J Hotchi, Mika Bando, S Nishio, R Tamai, M Nakagawa, D Hirota, Y Hirata and Masataka Sata :
Differentiation of Left Atrial Dysfunction From Pseudonormal/Restrictive Transmitral Flow Velocity Pattern in Patients With Preserved Ejection Fraction.,
American Society of Echocardiography (ASE) 23rd Annual Scientific Sessions, Maryland, Jun. 2012. Mika Bando, Hirotsugu Yamada, N Tomita, S. Nishio, R. Tamai, S. Hayashi, J. Hotchi, Takayuki Ise, Toshiyuki Niki, Koji Yamaguchi, Takashi Iwase, Yoshio Taketani, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Left Ventricular Geometry and Function in Patients with Sigmoid Septum.,
American Society of Echocardiography (ASE) 23rd Annual Scientific Sessions, Maryland, Jun. 2012. S Hayashi, Hirotsugu Yamada, N Tomita, J Hotchi, Mika Bando, S Nishio, R Tamai, M Nakagawa, Takayuki Ise, Toshiyuki Niki, Koji Yamaguchi, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Differentiation Between Hypertrophic Cardiomyopathy and Hypertensive Heart Disease Using Tricuspid Annular Motion Velocity.,
American Society of Echocardiography (ASE) 23rd Annual Scientific Sessions, Maryland, Jun. 2012. Mika Bando, Hirotsugu Yamada, S Nishio, R Tamai, N. Tomita, S. Hayashi, J. Hotchi, M. Nakagawa, D. Hirota, Y. Hirata, S. Bando, Takayuki Ise, Toshiyuki Niki, Koji Yamaguchi, Takashi Iwase, Yoshio Taketani, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Effect of Statin Therapy on Regression of Carotid Artery Plaque Assessed by High-Resolution Color Mapping Method Based on Integrated Backscatter.,
American Society of Echocardiography (ASE) 23rd Annual Scientific Sessions, Maryland, Jun. 2012. J. Hotchi, Hirotsugu Yamada, S Nishio, Kenya Kusunose, N Tomita, S Hayashi, Mika Bando, R Tamai, M Nakagawa, D Hirota, Y Hirata, K Ogasawara, S Bando, Takayuki Ise, Toshiyuki Niki, Koji Yamaguchi, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Efficacy of Six-minute Walk Stress Echocardiography for Detection of Pulmonary Arterial Hypertension in Patients With Connective Tissue Disease.,
American Society of Echocardiography (ASE) 23rd Annual Scientific Sessions, Maryland, Jun. 2012. J. Hotchi, Hirotsugu Yamada, R. Tamai, S. Nishio, N. Tomita, S. Hayashi, Mika Bando, S. Bando, Takayuki Ise, Toshiyuki Niki, Koji Yamaguchi, Takashi Iwase, Yoshio Taketani, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Assessment of Tricuspid Annular Motion Velocities in Pulmonary Hypertension of Various Etiologies.,
American Society of Echocardiography (ASE) 23rd Annual Scientific Sessions, Maryland, Jun. 2012. S. Nishio, Hirotsugu Yamada, R. Tamai, Y. Hirata, M. Sato, H. Hioraoka, S. Hayashi, N. Tomita, J. Hotchi, Mika Bando, M. Nakagawa, D. Hirota and Masataka Sata :
Non-invasive Assessment of Left Atrial-Left Ventricular-Arterial Coupling in Patients With Diabetes Mellitus.,
American Society of Echocardiography (ASE) 23rd Annual Scientific Sessions, Maryland, Jun. 2012. Kenya Kusunose, Hirotsugu Yamada, S. Nishio, N. Tomita, S. Hayashi, J. Hotchi, R. Tamai, D. Hirota, Y. Hirata, Mika Bando, K. Ogasawara, A. Takashima, H. Yamazaki, S. Bando, Takayuki Ise, Toshiyuki Niki, Koji Yamaguchi, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Single-Beat Assessment of Left Ventricular Systolic and Diastolic Function during Atrial Fibrillation using Myocardial Strain and Strain Rate.,
AHA Scientific Sessions 2011, Orlando, Nov. 2011. Takeshi Soeki, S. Bando, Toshiyuki Niki, H. Yamazaki, A. Takashima, K. Ogasawara, Mika Bando, Takayuki Ise, H. Takeuchi, N. Tomita, Yuka Ueda, Kenya Kusunose, Koji Yamaguchi, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki and Masataka Sata :
Pentraxin 3 is a Local Inflammatory Maker in Atrial Fibrillation.,
AHA Scientific Sessions 2011, Orlando, Nov. 2011. Mika Bando, Hirotsugu Yamada, S. Nishio, E. Uematsu, S. Hayashi, J. Hotchi, Kenya Kusunose, N. Tomita, R. Tamai, Y. Hirata, D. Hirota, M. Nakagawa, Toshiyuki Niki, Koji Yamaguchi, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Ultrasonic Tissue Characterization of Carotid Artery Plaque using High-resolution Integrated Backscatter Imaging;Validation Study with Histological Correlation.,
AHA Scientific Sessions 2011, Orlando, Nov. 2011. Koji Yamaguchi, Tetsuzo Wakatsuki, Takeshi Soeki, Toshiyuki Niki, Yoshio Taketani, H. Oezuka, S. Bando, N. Tomita, Kenya Kusunose, Takashi Iwase, Hirotsugu Yamada and Masataka Sata :
Effects of Telmisartan on Inflammatory Cytokines and Coronary Plaque Component Assessed by Integrated Backscatter Intravascular Ultrasound in Hypertensive Patients.,
AHA Scientific Sessions 2011, Orlando, Nov. 2011. Takashi Iwase, Shoichiro Takao, Masashi Akaike, Takayuki Ise, Toshiyuki Niki, Kenya Kusunose, Yuka Ueda, N. Tomita, Koji Yamaguchi, Yoshio Taketani, Hirotsugu Yamada, Takeshi Soeki, Ken-ichi Aihara, Tetsuzo Wakatsuki, Masafumi Harada and Masataka Sata :
Detection of Cardiac Involvement in Patients with Sarcoidosis Using Cardiac Magnetic Resonance.,
AHA Scientific Sessions 2011, Orlando, Nov. 2011. S. Nishio, Hirotsugu Yamada, R. Tamai, K. Endo, S. Hayashi, Kenya Kusunose, Takeshi Soeki, Tetsuzo Wakatsuki, Y. Sakai and Masataka Sata :
Deterioration of right ventricular myocardial systolic function in monocrotaline-induced pulmonary arterial hypertension canine model: echocardiographic evaluation by 2D speckle tracking.,
ESC Congress 2011, Paris, Aug. 2011. Koji Yamaguchi, Tetsuzo Wakatsuki, Toshiyuki Niki, Yoshio Taketani, S. Bando, Kenya Kusunose, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Differential response of local persistent hypercoagulability after zotarolimus-eluting, paclitaxel-eluting, sirolimus-eluting and bare-metal stent implantation in patients with stable angina.,
ESC Congress 2011, Paris, Aug. 2011. Koji Yamaguchi, Tetsuzo Wakatsuki, Toshiyuki Niki, Yoshio Taketani, S. Bando, Kenya Kusunose, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Time-dependent changes of local coagulative response up to five years after sirolimus-eluting and bare-metal stent implantation in patients with stable angina.,
ESC Congress 2011, Paris, Aug. 2011. Takeshi Soeki, S. Bando, Toshiyuki Niki, Kenya Kusunose, Koji Yamaguchi, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki and Masataka Sata :
Elevated concentration of pentraxin 3 is associated with local inflammation in atrial fibrillation.,
ESC Congress 2011, Paris, Aug. 2011. Tetsuzo Wakatsuki, Toshiyuki Niki, Koji Yamaguchi, Yoshio Taketani, Takashi Iwase, Kenya Kusunose, S. Bando, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Long-term local inflammatory and coagulative responses after coronary artery stenting with drug-eluting stent.,
ESC Congress 2011, Paris, Aug. 2011. R. Tamai, Hirotsugu Yamada, S. Nishio, Kenya Kusunose, N. Tomita, S. Hayashi, M. Sato, H. Hiraoka, J. Miki, Toshiyuki Niki, Koji Yamaguchi, Takashi Iwase, Yoshio Taketani, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Comparison of Tricuspid Annular Motion Velocities in Patients with Pulmonary Arteril Hypertension Secondary to Heart Failure.,
American Society of Echocardiography 2011. 22st Annual Scientific Sessions. Montreal, Montreal, Jun. 2011. 楠瀬賢也, 山田博胤, 西尾進, 冨田紀子, 林修司, 玉井利奈, 坂東左知子, 久岡白陽花, 仁木敏之, 上田由佳, 山口浩司, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
ストレインイメージング法を用いた心房細動例の左室心筋機能評価―左室圧曲線との同時記録による検討―,
第98回日本循環器学会中国・四国合同地方会, 徳島, 2011年5月. S Nishio, Hirotsugu Yamada, R Tamai, K Endo, S Hayashi, Kenya Kusunose, N Tomita, J Miki, S Bando, S Hisaoka, Toshiyuki Niki, Koji Yamaguchi, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Relationship Between Carotid Artery Stiffness Parameter β and Brachial Artery Flow-mediated Dilation in coronary Artery Disease.,
American College of Cardiology 2011, New Orleans, Apr. 2011. Koji Yamaguchi, Tetsuzo Wakatsuki, Toshiyuki Niki, Yoshio Taketani, S. Bando, S. Hisaoka, Kenya Kusunose, Yuka Ueda, H. Takeuchi, Takashi Iwase, N. Tomita, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Time-dependent Changes Of Local Coagulative Response Up To Five Years After Sirolimus-eluting Stent Implantation.,
American Heart Association 2010, Chicago, Nov. 2010. Tetsuzo Wakatsuki, Koji Yamaguchi, Toshiyuki Niki, Kenya Kusunose, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Long-Term Local Inflammatory and Coagulative Responses after Coronary Artery Stenting with Drug-Eluting Stent.,
American Heart Association 2010, Chicago, Nov. 2010. Kenya Kusunose, Hirotsugu Yamada, S. Nishio, N. Tomita, S. Hayashi, S. Bando, S. Hisaoka, Toshiyuki Niki, Koji Yamaguchi, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Left Ventricular Dyssynchrony during Lower Leg Positive Pressure Assessed by Real-time 3-dimensional Echocardiography.,
American Heart Association 2010, Chicago, Nov. 2010. Takeshi Soeki, Toshiyuki Niki, S. Bando, S. Hisaoka, H. Takeuchi, Kenya Kusunose, Koji Yamaguchi, Y. Hirata, N. Tomita, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Masashi Akaike, K. Kangawa and Masataka Sata :
Ghrelin Protects Heart Against Ischemia-Induced Arrhythmias by Preserving Connexin43 Protein.,
American Heart Association 2010, Chicago, Nov. 2010. Kenya Kusunose, Hirotsugu Yamada, S. Nishio, N. Tomita, S. Hayashi, S. Bando, S. Hisaoka, Toshiyuki Niki, Koji Yamaguchi, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Time Difference between Onset of Mitral Inflow and Onset of Early Diastolic Mitral Annulus Velocity Predicts Left Ventricular End-diastolic Pressure: Assessment by Dual Doppler Echocardiography.,
American Heart Association 2010, Chicago, Nov. 2010. Takeshi Soeki, Toshiyuki Niki, S. Bando, S. Hisaoka, H. Takeuchi, Kenya Kusunose, Koji Yamaguchi, Y. Hirata, N. Tomita, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Masashi Akaike, K. Kangawa and Masataka Sata :
Ghrelin Attenuates Myocardial Ischemia/Reperfusion Injury via the Extracellular Signal-Regulated Kinase 1/2 and Phosphatidylinositol 3-Kinase/Akt Pathway.,
American Heart Association 2010, Chicago, Nov. 2010. Toshiyuki Niki, Tetsuzo Wakatsuki, Koji Yamaguchi, Kenya Kusunose, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Impact of Statin Theraphy on Local Coagulative Response after sirolimus-eluting Stent Implantation in late chronic Phase.,
ESC CONGRESS 2010, Stockholm, Aug. 2010. Hirotsugu Yamada :
Interesting case: Atrial fibrillation.,
American Society of Echocardiography 2010 21st Annual Scientific Sessions., Jun. 2010. Kenya Kusunose, Hirotsugu Yamada, S Nishio, N Tomita, K Endo, H Takashima, C Mimura, M Yamanaka, J Miki, T Niki, Koji Yamaguchi, Kunihiko Koshiba, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Effect of Preload on Left Ventricular Dyssynchrony in Patients with Dilated Cardiomyopathy: Assessment with Real-Time Three-Dimensional Echocardiography.,
American Society of Echocardiography 2010 21st Annual Scientific Sessions, San Diego, Jun. 2010. H Takashima, Hirotsugu Yamada, Kenya Kusunose, S Nishio, N Tomita, C Mimura, K Endo, M Yamanaka, J Miki, T Niki, Koji Yamaguchi, Kunihiko Koshiba, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Association of Carotid Artery Atherosclerosis with Aortic Valve Sclerosis.,
American Society of Echocardiography 2010 21st Annual Scientific Sessions, San Diego, Jun. 2010. Hirotsugu Yamada, Kenya Kusunose, S Nishio, J Miki, N Tomita, H Takashima, C Mimura, M Yamanaka, T Niki, Koji Yamaguchi, Kunihiko Koshiba, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Identification of Pseudonormal / Restrictive Transmitral Flow Velocity Pattern Using its Response to Nitroglycerin Spray Oral Administration.,
American Society of Echocardiography 2010 21st Annual Scientific Sessions, San Diego, Jun. 2010. Hirotsugu Yamada, Kenya Kusunose, S Nishio, N Tomita, J Miki, Toshiyuki Niki, Koji Yamaguchi, Kunihiko Koshiba, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Identification of Pseudonormal Transmitral Flow Velocity Pattern using its Change by Nitroglycerin Spray Oral Administration.,
American College of Cardiology 2010, Mar. 2010. Kenya Kusunose, Hirotsugu Yamada, S Nishio, N Tomita, J Miki, T Niki, Koji Yamaguchi, Kunihiko Koshiba, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Doppler Echocardiographic Estimation of Left Ventricular End-diastolic Pressure in Challenging,
第74回日本循環器学会総会・学術集会, Mar. 2010. S Nishio, Hirotsugu Yamada, Kenya Kusunose, N Tomita, J Miki, T Niki, Koji Yamaguchi, Kunihiko Koshiba, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Evaluation of Secondary Pulmonary Hypertension by Tricuspid Annular Velocity Profile Using Pulsed Tissue Doppler Imaging.,
第74回日本循環器学会総会・学術集会, Mar. 2010. N Tomita, Hirotsugu Yamada, Kenya Kusunose, S Nishio, K Endo, H Takashima, C Mimura, T Niki, Koji Yamaguchi, Kunihiko Koshiba, Takashi Iwase, Yoshio Taketani, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Detection of Patent Foramen Ovale by Contrast Realtime 3-dimensional Transesophageal Echocardiography.,
第74回日本循環器学会総会・学術集会, Mar. 2010. K Endo, Hirotsugu Yamada, Kenya Kusunose, S Nishio, N Tomita, J Miki, T Niki, Koji Yamaguchi, Kunihiko Koshiba, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike, Ken Saito and Masataka Sata :
N-3 Fatty Acids, IMT and CKD as Risk Factors in Coronary Artery Disease.,
第74回日本循環器学会総会・学術集会, Mar. 2010. S Nishio, Hirotsugu Yamada, Kenya Kusunose, N Tomita, J Miki, K Endo, T Niki, Koji Yamaguchi, Kunihiko Koshiba, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Clinical Evaluation of Stiffness Parameter beta of Common Carotid Artery Obtained by Echo-tracking Method in Coronary Heart Disease.,
第74回日本循環器学会総会・学術集会, Mar. 2010. T Niki, Takeshi Soeki, Kunihiko Koshiba, Kenya Kusunose, Koji Yamaguchi, Y Hirata, N Tomita, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Role of Circulating High-Mobility Group Box-1 (HMGB1) in Patients with Coronary Artery Disease.,
第74回日本循環器学会総会・学術集会, Mar. 2010. Takashi Iwase, Shoichiro Takao, Masashi Akaike, K Adachi, Y Sumitomo, Shusuke Yagi, T Niki, Kenya Kusunose, N Tomita, Y Hirata, Koji Yamaguchi, Kunihiko Koshiba, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Ken-ichi Aihara, Masafumi Harada, Hiromu Nishitani and Masataka Sata :
Utility of Cardiac Magnetic Resonance for Detection of Cardiac Involvement in Female Carriers of Duchenne Muscular Dystrophy.,
第74回日本循環器学会総会・学術集会, Mar. 2010. Tetsuzo Wakatsuki, Koji Yamaguchi, T Niki, Kenya Kusunose, Kunihiko Koshiba, Takashi Iwase, Yoshio Taketani, N Tomita, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Long-Term Local Inflammatory and Coagulative Responses after Coronary Artery Stenting with Drug-Eluting Stent.,
第74回日本循環器学会総会・学術集会, Mar. 2010. Takeshi Soeki, Kunihiko Koshiba, T Niki, Kenya Kusunose, Koji Yamaguchi, Y Hirata, N Tomita, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Masashi Akaike, Kenji Kangawa and Masataka Sata :
Ghrelin Protects Heart against Ischemia-Induced Arrhythmias by Preserving Connexin43 Protein.,
第74回日本循環器学会総会・学術集会, Mar. 2010. Kenya Kusunose, Hirotsugu Yamada, S Nishio, N Tomita, J Miki, T Niki, Koji Yamaguchi, Kunihiko Koshiba, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Detection of Myocardial Amyloid Involvement Using 2-Dimentional Speckle Tracking Echocardiography: Utilization of Inner and Outer Myocardial Strain and Strain Rate.,
第74回日本循環器学会総会・学術集会, Mar. 2010. Koji Yamaguchi, Tetsuzo Wakatsuki, T Niki, Kenya Kusunose, Kunihiko Koshiba, Yoshio Taketani, Takashi Iwase, N Tomita, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Time-Dependent Changes of Local Coagulative Response up to Five Years after Sirolimus-Eluting Stent Implantation.,
第74回日本循環器学会総会・学術集会, Mar. 2010. C Mimura, Hirotsugu Yamada, Kenya Kusunose, S Nishio, N Tomita, J Miki, H Takashima, T Niki, Koji Yamaguchi, Kunihiko Koshiba, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Predictive Value of Subepicardial Fat Thickness in Coronary Artery Sclerosis in Comparison with Intima-media Thickness,
第74回日本循環器学会総会・学術集会, Mar. 2010. Sumiko Yoshida, Ken-ichi Aihara, Takayuki Ise, Yuka Ueda, Shusuke Yagi, Yasumasa Ikeda, Takashi Iwase, Kurahashi Kiyoe, Itsuro Endo, Yuichi Fujinaka, Nishio Susumu, Hirotsugu Yamada, Masashi Akaike, Masataka Sata and Toshio Matsumoto :
Dehydroepiandrosterone sulfate is an endothelial function-independent protective factor against carotid atherosclerosis.,
Scientific Sessions 2009, American Heart Association, Florida, Nov. 2009. Koji Yamaguchi, Tetsuzo Wakatsuki, T Niki, Kenya Kusunose, Kunihiko Koshiba, Shusuke Yagi, Yoshio Taketani, Takashi Iwase, N Tomita, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Predictors of Local Persistent Hypercoagulability After Sirolimus-eluting Stent Implantation: Implication for Correlates of Late Stent Thrombosis.,
American Heart Association 2009, Nov. 2009. Hirotsugu Yamada, Kenya Kusunose, S Nishio, N Tomita, K Endo, H Takashima, C Mimura, T Niki, Koji Yamaguchi, Kunihiko Koshiba, Yoshio Taketani, Shusuke Yagi, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Prognostic Value of Changes in Transmitral Flow Velocity Pattern During Leg Positive Pressure in Mild Heart Failure: A Clinical Application of "Preload Stress Echocardiography",
American Heart Association 2009, Nov. 2009. Tetsuzo Wakatsuki, T Niki, Kenya Kusunose, Koji Yamaguchi, Kunihiko Koshiba, Shusuke Yagi, N Tomita, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Long-Term Local Inflammatory Response After Coronary Artery Stenting. Bare Metal vs Sirolimus-Eluting vs Paclitaxel-Eluting Stent.,
American Heart Association 2009, Nov. 2009. Tetsuzo Wakatsuki, T Niki, Kenya Kusunose, Koji Yamaguchi, Kunihiko Koshiba, Shusuke Yagi, N Tomita, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Long-Term Local Inflammatory Response After Coronary Artery Stenting with Drug-Eluting Stent.,
American Heart Association 2009, Nov. 2009. Kunihiko Koshiba, Takeshi Soeki, T Niki, Kenya Kusunose, Y Hirata, Koji Yamaguchi, Shusuke Yagi, N Tomita, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Masashi Akaike, Kenji Kangawa and Masataka Sata :
C-type Natriuretic Peptide Ameliorates the Progression of Experimental Autoimmune Myocarditis.,
American Heart Association 2009, Nov. 2009. S Nishio, Hirotsugu Yamada, Kenya Kusunose, N Tomita, Y Tadatsu, M Sato, H Hiraoka and Masataka Sata :
Usefulness of B-Flow Imaging in Carotid Artery Ultrasound Examination.,
12th World Congress of the World Federation for Ultrasound in Medicine and Biology, Aug. 2009. Hirotsugu Yamada, Kenya Kusunose, N Tomita, Y Tadatsu, S Nishio, M Sato, H Hiraoka and Masataka Sata :
Enhance of Early Diastolic Left Ventricular Mismatch between Wall Motion and Inflow by Preload Augmentation: Assessment by Dual-Doppler Echocardiography.,
12th World Congress of the World Federation for Ultrasound in Medicine and Biology, Aug. 2009. Tetsuzo Wakatsuki, Koji Yamaguchi, T Niki, Kenya Kusunose, Kunihiko Koshiba, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Long-term local inflammatory response after coronary artery stenting -BMS vs SES vs PES-.,
ESC Congress 2009, Aug. 2009. Takeshi Soeki, T Niki, Kunihiko Koshiba, Kenya Kusunose, Koji Yamaguchi, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Plasma concentration of pentraxin 3 is a useful marker for monitoring the anti-plaque effect of telmisartan.,
ESC Congress 2009, Aug. 2009. Koji Yamaguchi, Tetsuzo Wakatsuki, T Niki, Kenya Kusunose, Kunihiko Koshiba, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Local persistent hypercoagulability after drug-eluting stent implantation: siroliumus-eluting stent vs. paclitaxel-eluting stent.,
ESC Congress 2009, Aug. 2009. Y Fukuda, Takeshi Soeki, N Fukuda, S Morishita, K Sakabe, H Shinohara, Y Tamura, Masashi Akaike, Tetsuzo Wakatsuki, Hirotsugu Yamada, Takashi Iwase, Shusuke Yagi, Kunihiko Koshiba, Koji Yamaguchi, Kenya Kusunose, T Niki and Masataka Sata :
Pentraxin 3, a Novel Inflammatory Marker, Predicts Left Ventricular Remodeling in Patients with Acute Myocardial Infarction.,
73th Annual scientific meeting of the Japanese circulation society, Mar. 2009. Shusuke Yagi, Masashi Akaike, Takashi Iwase, Kenya Kusunose, T Niki, Y Hirata, Koji Yamaguchi, Kunihiko Koshiba, N Tomita, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, S Yoshida, Y Sumitomo, Ken-ichi Aihara, Toshio Matsumoto and Masataka Sata :
Bosentan, an Endothelin Receptor Antagonist, Exerts Protective Actions against Systemic Sclerosis-related Peripheral Circulation Insufficiency.,
73th Annual scientific meeting of the Japanese circulation society, Mar. 2009. Y Hirata, H Iwata, K Nakamura, Y Sakai, N Tomita, T Niki, Kenya Kusunose, Koji Yamaguchi, Kunihiko Koshiba, Shusuke Yagi, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Synthetic Prostacycline Agonist, ONO-1301, Ameliorates Left Ventricular Dysfunction and Cardiac Fibrosis in Cardiomyopathic Hamsters.,
73th Annual scientific meeting of the Japanese circulation society, Mar. 2009. Kenya Kusunose, Hirotsugu Yamada, S Nishio, N Tomita, T Niki, Koji Yamaguchi, Kunihiko Koshiba, Shusuke Yagi, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Prediction of Cardiac Response to Preload Augmentation by Dual Doppler Echocardiography and Left Arial Volume Auto Tracking System.,
73th Annual scientific meeting of the Japanese circulation society, Mar. 2009. M Yamanaka, Hirotsugu Yamada, Kenya Kusunose, N Tomita, S Nishio, T Niki, Koji Yamaguchi, Kunihiko Koshiba, Shusuke Yagi, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike, Shinji Nagahiro and Masataka Sata :
Utilization of Echocardiography in Stroke Care Unit of Tokushima University Hospital.,
73th Annual scientific meeting of the Japanese circulation society, Mar. 2009. Takeshi Soeki, T Niki, Kunihiko Koshiba, Y Hirata, N Tomita, Kenya Kusunose, Koji Yamaguchi, Shusuke Yagi, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Masashi Akaike, H Satoh and Masataka Sata :
Plasma Concentration of Pentraxin 3 is a Useful Marker for Monitoring the Anti-plaque Effect of Telmisartan.,
73th Annual scientific meeting of the Japanese circulation society, Mar. 2009. Shusuke Yagi, Masashi Akaike, Ken-ichi Aihara, S Yoshida, Y Sumitomo, Kenya Kusunose, T Niki, Y Hirata, Koji Yamaguchi, Kunihiko Koshiba, Takashi Iwase, N Tomita, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Toshio Matsumoto and Masataka Sata :
Pitavastatin Exerts LDL Cholesterol Reduction-independent Protective Action for Cardiac and Renal Function in Patients with Dyslipidemia.,
73th Annual scientific meeting of the Japanese circulation society, Mar. 2009. Shusuke Yagi, Masashi Akaike, Ken-ichi Aihara, S Yoshida, Y Sumitomo, Kenya Kusunose, T Niki, Y Hirata, Koji Yamaguchi, Kunihiko Koshiba, Takashi Iwase, N Tomita, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Toshio Matsumoto and Masataka Sata :
Plasma Aldosterone Concentration is Associated with Cognitive Impairement in Patients with Hypertension.,
73th Annual scientific meeting of the Japanese circulation society, Mar. 2009. Koji Yamaguchi, Tetsuzo Wakatsuki, T Niki, Kenya Kusunose, Kunihiko Koshiba, N Tomita, Shusuke Yagi, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Local Persistent Hypercoagulability after Drug-Eluting Stent Implantation: Sirolimus-Eluting Stent vs. Paclitaxel-Eluting Stent.,
73th Annual scientific meeting of the Japanese circulation society, Mar. 2009. Takashi Iwase, Shoichiro Takao, Masashi Akaike, K Adachi, Y Sumitomo, Shusuke Yagi, T Niki, Kenya Kusunose, N Sakamoto, Y Hirata, Koji Yamaguchi, Kunihiko Koshiba, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Ken-ichi Aihara, Masafumi Harada, Hiromu Nishitani and Masataka Sata :
Early Detection of Myocardial Damage in Female Carriers of Duchenne Muscular Dystrophy - the Utility of Cardiac Magnetic Resonance.,
73th Annual scientific meeting of the Japanese circulation society, Mar. 2009. Hirotsugu Yamada, Kenya Kusunose, N Tomita, S Nishio, T Niki, Koji Yamaguchi, Kunihiko Koshiba, Shusuke Yagi, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Angiotensin-II Receptor Blocker Prevents the Deterioration of Left Ventricular Geometry and Diastolic Function in Hypertrophic Cardiomyopathy.,
73th Annual scientific meeting of the Japanese circulation society, Mar. 2009. Takeshi Soeki, Kunihiko Koshiba, T Niki, Y Hirata, N Tomita, Kenya Kusunose, Koji Yamaguchi, Shusuke Yagi, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Effect of Ghrelin on Autonomic Activity in Healthy Volunteers.,
73th Annual scientific meeting of the Japanese circulation society, Mar. 2009. Kenya Kusunose, Hirotsugu Yamada, S Nishio, N Tomita, T Niki, Koji Yamaguchi, Kunihiko Koshiba, Shusuke Yagi, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Elevation of Left Ventricular End-diastolic Pressure Enhances Mismatch between Mitral Inflow and Annular Motion.,
73th Annual scientific meeting of the Japanese circulation society, Mar. 2009. S Nishio, Hirotsugu Yamada, Kenya Kusunose, N Tomita, T Niki, Koji Yamaguchi, Kunihiko Koshiba, Shusuke Yagi, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Clinical utility of B-Flowimaging on ultrasound examination of carotid artery.,
73th Annual scientific meeting of the Japanese circulation society, Mar. 2009. M Yamanaka, Kenya Kusunose, Hirotsugu Yamada, S Nishio, N Tomita, T Niki, Koji Yamaguchi, Kunihiko Koshiba, Shusuke Yagi, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Postsystolic Shortening is Superior to Peak Systolic Strain on the Prediction of Ischemia in Normal Wall Motion Segments.,
73th Annual scientific meeting of the Japanese circulation society, Mar. 2009. Tetsuzo Wakatsuki, Koji Yamaguchi, T Niki, Kenya Kusunose, Kunihiko Koshiba, Shusuke Yagi, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Long-Term Local Inflammatory Response after Coronary Artery Stenting -BMS vs. SES vs. PES-,
73th Annual scientific meeting of the Japanese circulation society, Mar. 2009. Hirotsugu Yamada, Kenya Kusunose, S Nishio, N Tomita, T Niki, Koji Yamaguchi, Kunihiko Koshiba, Shusuke Yagi, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
The Mitral L-wave Predicts Adverse Response to Volume Overloading in Patients with Atrial Fibrillation.,
58th American College of Cardiology, Mar. 2009. S Nishio, Hirotsugu Yamada, Kenya Kusunose, N Tomita, T Niki, Koji Yamaguchi, Kunihiko Koshiba, Shusuke Yagi, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Tricuspid Annular Velocity Profile by Pulsed Tissue Doppler Imaging for the Assessment of Serial Change of Pulmonary Artery Pressure in Secondary Pulmonary Hypertension.,
58th American College of Cardiology, Mar. 2009. Tetsuzo Wakatsuki, K Yamaguchi, T Niki, Kenya Kusunose, K Koshiba, Hirotsugu Yamada, Takeshi Soeki, Shusuke Yagi, Takashi Iwase, Masashi Akaike and Masataka Sata :
Long-term endothelial dysfunction after coronary artery stenting with drug-eluting stent associated with local inflammatory response.,
American Heart Association 2008, New Orleans, Nov. 2008. K Yamaguchi, Tetsuzo Wakatsuki, T Niki, Kenya Kusunose, K Koshiba, Shusuke Yagi, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Local hypercoagulability and endothelial dysfunction after sirolimus-eluting stent implantation: implication for late stent thrombosis.,
American Heart Association 2008, New Orleans, Nov. 2008. Takeshi Soeki, T Niki, K Koshiba, Kenya Kusunose, K Yamaguchi, Hirotsugu Yamada and Tetsuzo Wakatsuki :
Elevated concentration of Pentraxin 3 is associated with coronary plaque vulnerability.,
ESC Congress 2008, Munich, Aug. 2008. Tetsuzo Wakatsuki, K Yamaguchi, Kenya Kusunose, T Niki, K Koshiba, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Long-term local inflammatory response after coronary artery stenting with drug-eluting stent.,
ESC Congress 2008, Munich, Aug. 2008. K Koshiba, Takeshi Soeki, T Niki, Kenya Kusunose, K Yamaguchi, Hirotsugu Yamada and Tetsuzo Wakatsuki :
C-type natriuretic peptide ameliorates the progression of experimental autommune myocarditis.,
ESC Congress 2008, Munich, Aug. 2008. S Nishio, Hirotsugu Yamada, H Motonari, H Okada, Kenya Kusunose, Y Tadatsu, M Sato, H Hiraoka, H Kawano, Takeshi Soeki, Tetsuzo Wakatsuki and Masashi Akaike :
Assessment of Left Atrial Ejection Force in Patients with Hypertensive Heart Disease.,
18th Annual Scientific Sessions of the American Society of Echocardiography, Toronto, Jun. 2008. Kenya Kusunose, Hirotsugu Yamada, S Nishio, M Sato, H Hiraoka, H Kawano, Y Tadatsu, Takeshi Soeki, Tetsuzo Wakatsuki and Masashi Akaike :
Importance of Left Atrial Function in Cardiac Response to Increment of Preload in Patients with Old Myocardial Infarction: Assessment by Automated Left Atrial Volume Tracking Method.,
18th Annual Scientific Sessions of the American Society of Echocardiography, Toronto, Jun. 2008. S Nishio, Hirotsugu Yamada, Kenya Kusunose, Y Tadatsu, M Sato, H Hiraoka, H Kawano, Takeshi Soeki, Tetsuzo Wakatsuki and Masashi Akaike :
Beat-To-Beat Variation of Mitral Annular Velocities in Atrial Fibrillation.,
18th Annual Scientific Sessions of the American Society of Echocardiography, Toronto, Jun. 2008. Hirotsugu Yamada, Kenya Kusunose, S Nishio, Y Tadatsu, M Sato, H Hiraoka, H Kawano, T Niki, K Yamaguchi, K Koshiba, Takeshi Soeki, Tetsuzo Wakatsuki and Masashi Akaike :
The Mitral L-Wave Predicts the Cardiac Response to Preload Increment in Atrial Fibrillation.,
18th Annual Scientific Sessions of the American Society of Echocardiography, Toronto, Jun. 2008. S Nishio, Hirotsugu Yamada, Kenya Kusunose, Y Tadatsu, M Sato, H Hiraoka, H Kawano, T Niki, K Yamaguchi, K Koshiba, Takeshi Soeki, Tetsuzo Wakatsuki and Masashi Akaike :
Usefulness of Tei Index in Atrial Fibrillation: Assessment by Dual Doppler Echocardiography.,
18th Annual Scientific Sessions of the American Society of Echocardiography, Toronto, Jun. 2008. Kenya Kusunose, K Takechi, S Nishio, Y Tadatsu, T Niki, K Yamaguchi, K Koshiba, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike, M Choraku, Y Maeda and Hirotsugu Yamada :
Multicenter Trial for the Validation of Automated Function Imaging in Patients with Local Left Ventricular Asynergy (VANILLA Study),
18th Annual Scientific Sessions of the American Society of Echocardiography, Toronto, Jun. 2008. Kenya Kusunose, Hirotsugu Yamada, S Nishio, T Niki, K Yamaguchi, K Koshiba, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki and Masashi Akaike :
Role of Left Atrial Function for Pseudonormalization of Transmitral Flow Velocity Pattern in Patients with Hypertrophic Cardiomyopathy.,
18th Annual Scientific Sessions of the American Society of Echocardiography, Toronto, Jun. 2008. Kenya Kusunose, Hirotsugu Yamada, S Nishio, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki and Masashi Akaike :
Effect of Preload Increment on Early Diastolic Transmitral and Mitral Annular Velocities in Patients with Old Myocardial Infarction.,
The 16th Congress of the international Cardiac Doppler Society, Kobe, Apr. 2008. Hirotsugu Yamada, Kenya Kusunose, S Nishio, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki and Masashi Akaike :
The Mitral L-wave Predicts the Cardiac Response to an Increase of Preload in Atrial Fibrillation.,
The 16th Congress of the international Cardiac Doppler Society, Kobe, Apr. 2008. Hirotsugu Yamada :
Tissue Doppler Imaging as a Practical Clinical Tool.,
第72回日本循環器学会総会, Mar. 2008. Kenya Kusunose, Hirotsugu Yamada, T Niki, T Nakajima, K Yamaguchi, K Koshiba, Tomohito Kawano, Takeshi Soeki and Tetsuzo Wakatsuki :
Measurement of Left Atrial Volume Curve by Advanced 2D Tissue Tracking Technique: Validation by Contrast Multidetector Computed Tomography.,
17th Annual Scientific Sessions of the American Society of Echocardiography, Seattle, Jun. 2007. Hirotsugu Yamada, Kenya Kusunose, T Niki, T Nakajima, K Yamaguchi, K Koshiba, Tomohito Kawano, Takeshi Soeki and Tetsuzo Wakatsuki :
Assessment of the Cardiac Response to Increment of Preload in Patients with Atrial Fibrillation Using Dual Pulsed Doppler Echocardiography.,
17th Annual Scientific Sessions of the American Society of Echocardiography, Seattle, Jun. 2007. Kenya Kusunose, Hirotsugu Yamada, T Niki, T Nakajima, K Yamaguchi, K Koshiba, Tomohito Kawano, Takeshi Soeki, Tetsuzo Wakatsuki and Susumu Ito :
Relationship Between the Ratio of Peak Early diastolic Transmitral Flow and Mitral Annular Velocities and the Plasma B-Type Natriuretic Peptide (BNP) Concentration in Patients with Atrial Fibrillation: Assessment by Simultaneous Recording of Transmitral Flow and Mitral Annular Velocity.,
American College of Cardiology 56th Annual Scientific Session, New Orleans, Mar. 2007. K Matsuoka, M Nishino, A Hashimoto, K Yamagami, T Tamai, H Kato, Y Egami, R Shutta, H Yamaguchi, K Tanaka, J Tanouchi, Y Yamada and Hirotsugu Yamada :
Right Ventricular Apical Pacing Impairs Left Ventricular Torsion as Well as Synchrony.,
The American Heart Association's Scientific Sessions 2006, Chicago, Nov. 2006. K Koshiba, Takeshi Soeki, Y Fukuda, K Yamaguchi, Tomohito Kawano, Hirotsugu Yamada, Tetsuzo Wakatsuki and Kenji Kangawa :
Ghrelin prevents cardiac remodeling after myocardial infarction via the suppression of cardiac sympathetic nerve activity.,
World Congress of Cardiology 2006, Barcelona, Sep. 2006. Tetsuzo Wakatsuki, K Yamaguchi, Y Fukuda, K Koshiba, Tomohito Kawano, Takeshi Soeki and Hirotsugu Yamada :
Long-term endothelial dysfunction after coronary artery stenting with drug-eluting stent.,
World Congress of Cardiology 2006, Barcelona, Sep. 2006. Y Fukuda, Takeshi Soeki, K Yamaguchi, K Koshiba, Tomohito Kawano, Hirotsugu Yamada, Tetsuzo Wakatsuki and Kenji Kangawa :
Significance and therapeutic potential of C-type natriuretic peptide in myocardial infarction.,
World Congress of Cardiology 2006, Barcelona, Sep. 2006. Hirotsugu Yamada, Y Fukuda, K Yamaguchi, K Koshiba, Tomohito Kawano, Takeshi Soeki, Tetsuzo Wakatsuki and Susumu Ito :
Differentiation of Left Atrial Dysfunction by Changes in Transmitral Flow Velocities during Lower Body Positive Pressure.,
17th Annual Scientific Sessions of the American Society of Echocardiography, Baltimore, Jun. 2006. Hirotsugu Yamada, H Motonari, Y Fukuda, K Yamaguchi, K Koshiba, Tomohito Kawano, Takeshi Soeki, Tetsuzo Wakatsuki and Susumu Ito :
Effect of Aging on Left Atrial Myocardial Strain Evaluated by 2D Tissue Tracking during Lower Body Positive Pressure.,
17th Annual Scientific Sessions of the American Society of Echocardiography, Baltimore, Jun. 2006. Hirotsugu Yamada :
Quantitative evaluation of left atrial function by2-dimensional tissue tracking with lower body positivepressure.,
11th Congress of the World Federation for Ultrasound in Medicine and Biology (WFUMB'2006), Seoul, May 2006. WD Wallick, Hirotsugu Yamada, ZB Popovic and WC Stanley :
Coupled pacing improves cardiac work without further increases in substrate utilization during acute atrial fibrillation.,
Heart Rhythm 2006 annual scientific sessions, Boston, May 2006. Tomohito Kawano, Yamato Fukuda, Tomonori Watanabe, Koji Yamaguchi, Kunihiko Koshiba, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Tomotsugu Tabata and Masahiro Nomura :
Coronary Atherosclerotic Plaque Stabilization of HMG-CoA Reductase inhibitor, Atorvastatin, Evaluated by 16-slice Multidetector-row CT (MDCT),
The 70th general meeting of a Japanese circulatory organ disease society, Mar. 2006. Takeshi Soeki, Y Fukuda, K Koshiba, K Yamaguchi, Tomohito Kawano, Hirotsugu Yamada, Tetsuzo Wakatsuki, Masahiro Nomura, K Kangawa and Susumu Ito :
Ghrelin Protects Myocardium Against Ischemia/Reperfusion Injury via Inhibiting Myocardial Apoptosis.,
American College of Cardiology 55th Annual Scientific Session, Atlanta, Mar. 2006. Tomotsugu Tabata, Hirotsugu Yamada, S Yamada, A Watanabe, M Daisuke, K Tamura, H Yokoi and Masahiro Nomura :
Difference in the Left Atrial Function Between Patients With Hypertensive Hypertrophy and Hypertrophic Cardiomyopathy Evaluated by Tissue Strain Imaging.,
American College of Cardiology 54th Annual Scientific Session, Atlanta, Mar. 2006. PB Zoran, Hirotsugu Yamada, Y Zhang, RA Grimm, JD Thomas and TN Mazgalev :
Incomplete Relaxation and Excess Left Ventricular End-Diastolic Pressure during Atrial Fibrillation.,
The American Heart Association's Scientific Sessions 2005, Dallas, Nov. 2005. Tomotsugu Tabata, Hirotsugu Yamada, H Tanaka, Y Saito, K Harada, Masahiro Nomura and Susumu Ito :
Pseudonormalization of the transmitral inflow Doppler velocities re-evaluated in relation to the left atrial function using tissue strain imaging.,
16th Annual Scientific Sessions of the American Society of Echocardiography, Boston, Jun. 2005. Hirotsugu Yamada, Tomotsugu Tabata, K Harada, H Tanaka, T Yoshida, Masahiro Nomura and Susumu Ito :
Quantitative assessment of biphasic response to dobutamine by tissue strain echocardiography.,
16th Annual Scientific Sessions of the American Society of Echocardiography, Boston, Jun. 2005. Hirotsugu Yamada, Tomotsugu Tabata, H Tanaka, K Harada, Masahiro Nomura and Susumu Ito :
Long-term left ventricular morphologic change in hypertrophic cardiomyopathy: a relationship with development of atrial fibrillation.,
16th Annual Scientific Sessions of the American Society of Echocardiography, Boston, Jun. 2005. Hirotsugu Yamada :
ARB improves regional left ventricular systolic and diastolic function in patients with hypertension: Evaluation using tissue Doppler imaging.,
Symposium on Angiotensin II receptor blocker (ARB) effect on the heart, Seoul, Apr. 2005. Tomotsugu Tabata, H Tanaka, Hirotsugu Yamada, Y Saito, K Harada, Masahiro Nomura and Susumu Ito :
Quantitative and Direct Assessment of the Left Atrial Reservoir Function Using Tissue Strain Imaging.,
American College of Cardiology 54th Annual Scientific Session, Orlando, Mar. 2005. Hirotsugu Yamada, Y Ootaki, ZB Popovic, M Daimon, K Kamohara, DW Wallick, JD Thomas, D Wagoner Van, K Fukamachi and Y Cheng :
Decreased Arrhythmia Vulnerability in a Novel Rabbit Model of Left Ventricular Aneurysm Repair.,
American College of Cardiology 54th Annual Scientific Session, Orlando, Mar. 2005. Tomotsugu Tabata, Hirotsugu Yamada, E Kimura, H Tanaka, K Harada, Masahiro Nomura and Susumu Ito :
Effect of Left Ventricular Geometry on Systolic Myocardial Velocity Gradient in Patients With Hypertension.,
American College of Cardiology 54th Annual Scientific Session, Orlando, Mar. 2005. T Takezako, R Ramchandran, Y Saad, Hirotsugu Yamada, JD Thomas, R Desnoyer, B Fink, DG Harrison and SS Karnik :
Endothelial AT1 Receptor Overexpression Produces Hypotension and Bradycardia in mMice: The Role of Nitric Oxide.,
The American Heart Association's Scientific Sessions 2004, New Orleans, Nov. 2004. Y Notomi, T Shiota, MG Martin-Miklovic, ZB Popovic, Hirotsugu Yamada, SJ Oryszak, DW Wallick and RA Grimm :
Effect of Alteration of Left Ventricular Activation Sequence on the Left Ventricular Torsional Deformation in Anesthetized Closed-chest Dogs.,
The American Heart Association's Scientific Sessions 2004, New Orleans, Nov. 2004. ZB Popovic, JP Sun, Hirotsugu Yamada, J Drinko, Y Cheng, K Mauer, CS Moravec and MS Penn :
Left Ventricular Long Axis Function Shows an Atypical Allometric Scaling to Ventricular Size.,
The American Heart Association's Scientific Sessions 2004, New Orleans, Nov. 2004. Hirotsugu Yamada, A Verma, NF Marrouche, A Natale, JD Thomas and RA Grimm :
Intracardiac Doppler echocardiographic assessment of left atrial function pre and post pulmonary vein isolation for prediction of short-term recurrence of atrial fibrillation.,
American Society of Echocardiography 15th Annual Scientific Sessions, San Diego, Jun. 2004. Hirotsugu Yamada, NF Marrouche, A Natale, JD Thomas and RA Grimm :
Comparison of left and right atrial stunning after conversion of chronic atrial fibrillation to sinus rhythm.,
American Society of Echocardiography 15th Annual Scientific Sessions, San Diego, Jun. 2004. A Verma, Hirotsugu Yamada, JE Cummings, JD Burkhardt, Y Khaykin, M Bhargava, AA Karim, RA Grimm, NF Marrouche and A Natale :
Intracardiac Doppler assessment of left atrial function immediately Post-Pulmonary Vein Isolation maybe predictive of short-term recurrence of atrial fibrillation.,
NASPE 2004, San Francisco, May 2004. Hirotsugu Yamada, ZB Popovic, WJ Kawalewski, DO Martin, RA Grimm and DW Wallick :
Coupled Pacing Improves Stroke Work Without Increasing Myocardial Oxygen Consumption During Acute Heart Failure and Atrial Fibrillation.,
NASPE 2004, San Francisco, May 2004. ZB Popovic, Hirotsugu Yamada, Y Zhang, DW Wallick, RA Grimm, JD Thomas and TN Mazgalev :
Frank Starling Mechanism Is an Independent Contributor to Ventricular Performance Variability in Atrial Fibrillation.,
American College of Cardiology 53th Annual Scientific Session, New Orleans, Mar. 2004. Y Notomi, RM Setser, T Shiota, MG Martin-Miklovic, JM Kasper, ZB Popovic, Hirotsugu Yamada, DG Deserranno, NL Greenberg, MJ Garcia, RD White and JD Thomas :
Assessment of Left Ventricular Torsional Deformation by Doppler Tissue Imaging: A Validation Study Using Tagged Magnetic Resonance Imaging.,
American College of Cardiology 53th Annual Scientific Session, New Orleans, Mar. 2004. Y Notomi, T Shiota, ZB Popovic, Hirotsugu Yamada, MG Martin-Miklovic, DG Deserranno, DW Wallick, NL Greenberg, MJ Garcia and JD Thomas :
Assessment of Ventricular Untwisting Recoil Velocity by Doppler Tissue Echocardiography: An Index of Relaxation Time Constant.,
American College of Cardiology 53th Annual Scientific Session, New Orleans, Mar. 2004. DW Wallick, Hirotsugu Yamada, ZB Popovic, WJ Kowalewski, NL Greenberg and DO Martin :
Rate Control by Coupled Pacing During Atrial Fibrillation Increases Myocardial Efficiency.,
American College of Cardiology 53th Annual Scientific Session, New Orleans, Mar. 2004. Hirotsugu Yamada, Tomotsugu Tabata, JK Drinko, SE Jasper, MS Lauer, JD Thomas and AL Klein :
Clinical Features of Mixed Physiology of Constriction and Restriction.,
American College of Cardiology 53th Annual Scientific Session, New Orleans, Mar. 2004. Y Eto, Hirotsugu Yamada, T Shiota, JH Shin, J Qin, DA Agler and G Saracino :
Assessment of Longitudinal and Radial Mitral Annular Movement in Left Ventricular Dysfunction Using Automated Mitral Annular Tracking.,
The American Heart Association's Scientific Sessions 2003, Orlando, Nov. 2003. Y Eto, Hirotsugu Yamada, Y Zhang, DA Agler, E Donal and TN Mazgalev :
Effect of Ventricular Slowing During Atrial Fibrillation on Relationship Between Cycle Length Irregularity and Mitral Annular Velocity: A Chronic Conscious Canine Model.,
The American Heart Association's Scientific Sessions 2003, Orlando, Nov. 2003. Hirotsugu Yamada, Y Notomi, E Donal, EB Saad, JD Thomas and RA Grimm :
Left Atrial Appendage Flow Velocity During Atrial Fibrillation Predicts the Degree of Stunnning After Conversion to Sinus Phythm: Assessment by Intracardiac Echocardiography in Patients Undergoing Pulmonary Vein Isolation Ablation.,
The American Heart Association's Scientific Sessions 2003, Orlando, Nov. 2003. Hirotsugu Yamada, NL Greenberg, KA Mowrey, DO Martin and DW Wallick :
Coupled Pacing: A Novel Method To Improve Left Ventricular Pump Function During Atrial Fibrillation with Heart Failure.,
The American Heart Association's Scientific Sessions 2003, Orlando, Nov. 2003. Hirotsugu Yamada, Y Zhang, DA Agler, KA Mowrey, DW Wallick and RA Grimm :
Ventricular Slowing by AV Nodal Vagal Stimulation Improves Left Ventricular Systolic Function During Atrial Fibrillation: A Chronic Study in Conscious Canines.,
The American Heart Association's Scientific Sessions 2003, Orlando, Nov. 2003. E Kimura, Tomotsugu Tabata, H Tanaka, K Harada, Hirotsugu Yamada, Masahiro Nomura, T Oki and Susumu Ito :
Better Choice of Color Tissue Doppler Imaging Coupled with High Dose Dobutamine Stress Echocardiography for Detection Coronary Artery Snotosis.,
American Society of Echocardiography 14th Annual Scientific Sessions, Las Vegas, Jun. 2003. Tomotsugu Tabata, H Tanaka, K Harada, E Kimura, Hirotsugu Yamada, Masahiro Nomura, T Oki and Susumu Ito :
Assessment of the Left Ventricular Diastolic Function Independent of Cardiac Translation Using a Newly Developed Tissue Strain Imaging.,
American Society of Echocardiography 14th Annual Scientific Sessions, Las Vegas, Jun. 2003. H Tanaka, Tomotsugu Tabata, E Kimura, K Harada, Hirotsugu Yamada, Masahiro Nomura, T Oki and Susumu Ito :
Impact of Angiotensin II receptor Antagonist on Left Ventricular Myocardial Function on Hypertensive Hypertrophy: Assessment of Myocardial Velocity Profile and Plasma Vasoactive Peptide.,
American Society of Echocardiography 14th Annual Scientific Sessions, Las Vegas, Jun. 2003. JP Sun, L Zhang, Hirotsugu Yamada, NL Greenberg, A Borowski, X Zhou, K Wang, L Fan, WJ Stewart, AL Klein and JD Thomas :
Issue Doppler, Displacement, and Strain Rate in Acute Myocardial Ischemia.,
American Society of Echocardiography 14th Annual Scientific Sessions, Las Vegas, Jun. 2003. Y Eto, T Shiota, JX Qin, J-H Shin, Hirotsugu Yamada, F Bauer, DA Agler, G Saracino, NL Greenberg and JD Thomas :
Assessment of Left Atrial Conduit Volume in Patients with Hypertrophic Cardiomyopathy Using Real-Time Three-Dimensional Echocardiography.,
American Society of Echocardiography 14th Annual Scientific Sessions, Las Vegas, Jun. 2003. Z Popovic, Hirotsugu Yamada, AT Askari, JK Drinko, J-H Shin, NL Greenberg, A Morehead, MS Penn and JD Thomas :
Tissue Doppler Echocardiography in Normal and Myocardial Infarction Rats: Mitral Annular Velocity, Myocardial Strain and Strain Rate.,
American Society of Echocardiography 14th Annual Scientific Sessions, Las Vegas, Jun. 2003. Y Notomi, ZB Popovic, Hirotsugu Yamada, D Deserrano, JX Qin, NL Greenberg, JD Thomas and T Shiota :
Temporal Relation Between Left Ventricular Torsional, Longitudinal and Radial Recoil in Early Diastole Assessed by Tissue Doppler Echocardiography.,
American Society of Echocardiography 14th Annual Scientific Sessions, Las Vegas, Jun. 2003. Y Notomi, Hirotsugu Yamada, Z Popovic, JX Qin, D Deserranno, NL Greenberg, JD Thomas and T Shiota :
Assessment of Left Ventricular Twisting During Exercise Using Tissue Doppler Echocardiography.,
American Society of Echocardiography 14th Annual Scientific Sessions, Las Vegas, Jun. 2003. E Donal, Hirotsugu Yamada, DW Wallick, M Martin, JD Thomas and LL Rodriguez :
Assessment of Left Atrial Systolic Function During Isovolumetric Atrial Contraction: Interest of the Pulmonary Vein Flow A-Reversal Peak Velocity-About Eight Acute Normal Dogs Experiment.,
American College of Cardiology 52st Annual Scientific Session, Chicago, Mar. 2003. Tomotsugu Tabata, H Tanaka, E Kimura, K Harada, Tetsuzo Wakatsuki, T Yamamoto, A Saito, K Uehara, N Kageyama, Hirotsugu Yamada and T Oki :
Longitudinal Myocardial Displacement and Strain Rate in the Hypertrophied Heart Evaluated by Tissue Strain Imaging With Doppler Angle Correction and Tissue Tracking Technique.,
American College of Cardiology 52st Annual Scientific Session, Chicago, Mar. 2003. E Donal, RA Grimm, Hirotsugu Yamada, Y Kim, NF Marrouche, A Natale and JD Thomas :
Recovery of Left Atrial Function Following Pulmonary Vein Isolation Using Radiofrequency Ablation in Chronic Atrial Fibrillation: An Intracardiac Doppler Echocardiographic Study.,
American College of Cardiology 52st Annual Scientific Session, Chicago, Mar. 2003. Y Notomi, Hirotsugu Yamada, ZB Popovic, JX Qin, NL Greenberg, Y Abe, R kanda, JD Thomas and T Shiota :
Wringing Motion of Normal Left Ventricle Quantified With Tissue Doppler Echocardiography.,
American College of Cardiology 52st Annual Scientific Session, Chicago, Mar. 2003. Hirotsugu Yamada, JK Drinko, AJ Morehead, LL Rodriguez, MJ Garcia, JD Thomas and AL Klein :
Dose Pericardiectomy Improve Outcome of Patients With Mixed Constriction and Restriction.,
American College of Cardiology 52st Annual Scientific Session, Chicago, Mar. 2003. Hirotsugu Yamada, RA Grimm, NL Greenberg, E Donal, Y Kim, DA Agler, Y Zhang, S Zhuang, KA Mowrey, DR Wagoner Von, TN Mazgalev and JD Thomas :
Ascorbic Acid Accelerates Left Atrial Mechanical Recovery Following a Brief Duration of Atrial Fibrillation.,
American College of Cardiology 52st Annual Scientific Session, Chicago, Mar. 2003. Hirotsugu Yamada, DW Wallick, NL Greenberg and DO Martin :
Bigeminal Pacing: A Novel Method to Improve Left Ventricular Pump Function during Atrial Tachycardia and Fibrillation.,
American Heart Association Scientific Sessions 2002, Chicago, Nov. 2002. Hirotsugu Yamada, Y Kim, DA Agler, Z Youhua, S Zhuang, KA Mowrey, Tomotsugu Tabata, TN Mazgalev and RA Grimm :
Importance of Passive Relaxation of the Left Atrial Appendage in Recovery from Stunning after Conversion of Atrial Fibrillation to Sinus Rhythm.,
American Heart Association Scientific Sessions 2002, Chicago, Nov. 2002. Hirotsugu Yamada, E Donal, Y Kim, Tomotsugu Tabata, DA Agler, S Zhuang, Z Youhua, KA Mowrey, TN Mazgalev and RA Grimm :
The "Pseudo-Restrictive" Pattern of Transmitral Doppler Flow Following Conversion of Atrial Fibrillation to Sinus Rhythm: Is Atrial Or Ventricular Dysfunction to Blame?,
American Heart Association Scientific Sessions 2002, Chicago, Nov. 2002. Y Eto, T Shiota, Hirotsugu Yamada, J Qin, H Tsujino, DA Agler, J Shin, G Saracino, NL Greenberg and JD Thomas :
Automated Tracking of Mitral Annular Motion Using Two-Dimensional Echocardiography for Evaluation of Left Vetricular Function: A Comparison With Real-Time Three-Dimensional.,
American Heart Association Scientific Sessions 2002, Chicago, Nov. 2002. T Zhang, S Zhuang, Hirotsugu Yamada, Y Kim, E Donal, DA Agler, RA Grimm, W Kowalewski, KA Mowrey, DW Wallick, HA III McDonald, K Morgan, J Poore, J Amely-Velez, G Bornzin and TN Mazgalev :
Long-term vagally controlled ventricular rate in atrial fibrillation.,
XIIIth International Congress, A World Congress in Cardiac Electrophysiology (Cardiostim 2002), Niece, Jun. 2002. E Kimura, Tomotsugu Tabata, H Tanaka, Tetsuzo Wakatsuki, T Yamamoto, A Saito, Hirotsugu Yamada and T Oki :
Determinants of the Left Ventricular Myocardial Contractility in Patients with Hypertension Evaluated by Newly Developed Averaged Myocardial Velocity Profile.,
American Society of Echocardiography 13th Annual Scientific Sessions, Orlando, Jun. 2002. H Tanaka, Tomotsugu Tabata, E Kimura, Tetsuzo Wakatsuki, T Yamamoto, A Saito, Hirotsugu Yamada and T Oki :
Temporal Change in the Left Ventricular Transmyocardial Systolic Velocity Profile Evaluated by Color Tissue Doppler Imaging.,
American Society of Echocardiography 13th Annual Scientific Sessions, Orlando, Jun. 2002. H Tanaka, Tomotsugu Tabata, E Kimura, Tetsuzo Wakatsuki, T Yamamoto, A Saito, Hirotsugu Yamada and T Oki :
Noninvasive Assessment of Myocardial Ischemia and Necrosis Using a Newly Developed Tissue Doppler Myocardial Velocity Profile.,
American Society of Echocardiography 13th Annual Scientific Sessions, Orlando, Jun. 2002. H Tanaka, Tomotsugu Tabata, E Kimura, Tetsuzo Wakatsuki, T Yamamoto, A Saito, Hirotsugu Yamada and T Oki :
Effect of Angiotensin II Receptor Antagonist on Left Ventricular Myocardial Relaxation Abnormality in Hypertensive Patients: Evaluation Using a Newly Developed Myocardial Velocity Profile.,
American Society of Echocardiography 13th Annual Scientific Sessions, Orlando, Jun. 2002. Tomotsugu Tabata, T Oki, H Tanaka, E Kimura, Tetsuzo Wakatsuki, T Yamamoto, A Saito and Hirotsugu Yamada :
Novel Index for Evaluating Wall Motion Abnormality Using Newly Developed Angle-Corrected Tissue Strain Imaging.,
American Society of Echocardiography 13th Annual Scientific Sessions, Orlando, Jun. 2002. Tomotsugu Tabata, T Oki, H Tanaka, E Kimura, Tetsuzo Wakatsuki, T Yamamoto, A Saito and Hirotsugu Yamada :
Quantitative Analysis Of The Left Ventricular Segmental Contractility In The Normal Subjects Using Newly Developed Angle-corrected Tissue Strain Imaging.,
American Society of Echocardiography 13th Annual Scientific Sessions, Orlando, Jun. 2002. E Donal, Hirotsugu Yamada, Y Kim, Y Zhang, DA Agler, RA Grimm, TN Mazgalev and JD Thomas :
Demonstration of vagally controlled ventricular rate potential interest during AF in chronically instrumented dogs. First experience.,
American Society of Echocardiography 13th Annual Scientific Sessions, Orlando, Jun. 2002. E Donal, Hirotsugu Yamada, Y Kim, NL Greenberg, DA Agler, S Zhuang, Y Zhang, DW Wallick, TN Mazgalev, JD Thomas and RA Grimm :
Ventricular Rate Slowing Imoroves Left Atrial Appendage Function in Atrial Fibrillation. Potential Interest to Vagal Nerve Stimulation to Control Atrio-Ventricular Conduction.,
American Society of Echocardiography 13th Annual Scientific Sessions, Orlando, Jun. 2002. Y Kim, M Jones, T Shiota, JX Qin, NL Greenberg, ZB Popovic, J Kwan, Hirotsugu Yamada, Y Eto, J Shin, AD Zetts, V Sachdev and JD Thomas :
Impact Of Infarct Size On The End-Systolic Pressure-Area Relation Of Remote Non-Infarcted Myocardium In Chronic Myocardial Infarction: An Animal Study.,
American Society of Echocardiography 13th Annual Scientific Sessions, Orlando, Jun. 2002. Hirotsugu Yamada, M Jones, T Shiota, JX Qin, Y Kim, NL Greenberg, Y Abe, H Tsujino, R Kanda, AD Zetts and JD Thomas :
Effect of an Increase in Afterload on Tissue Doppler Derived Systolic Myocardial Velocity Gradient.,
American Society of Echocardiography 13th Annual Scientific Sessions, Orlando, Jun. 2002. Hirotsugu Yamada, M Jones, T Shiota, JX Qin, Y Kim, NL Greenberg, H Tsujino, Y Abe, R Kanda, AD Zetts and JD Thomas :
Assessment of the Longitudinal (Apex to Base) Myocardial Velocity Profile Using Tissue Doppler Imaging in Sheep with Chronic Myocardial Infarction.,
American Society of Echocardiography 13th Annual Scientific Sessions, Orlando, Jun. 2002. Hirotsugu Yamada, RA Grimm, Y Kim, E Donal, NL Greenberg, DA Agler, S Zhuang, Y Zhang, TN Mazgalev and JD Thomas :
"Stunning" After a Brief Duration of Atrial Fibrillation is Greater in the Left Atrial Appendage than Left Atrium.,
American Society of Echocardiography 13th Annual Scientific Sessions, Orlando, Jun. 2002. Hirotsugu Yamada, RA Grimm, Y Kim, E Donal, NL Greenberg, DA Agler, Y Zhang, S Zhuang, TN Mazgalev and JD Thomas :
Ascorbic Acid Accelerates Left Atrial Functional Recovery Following a Short Duration of Atrial Fibrillation.,
American Society of Echocardiography 13th Annual Scientific Sessions, Orlando, Jun. 2002. Y Zhang, S Zhuang, Hirotsugu Yamada, Y Kim, E Donal, DA Agler, RA Grimm, W Kowalewski, KA Mowrey, DW Wallick, HA III McDonald, K Morgan, J Poore, J Amely-Velez, J Bornzin and TN Mazgalev :
First successful demonstration of vagally controlled ventricular rate during AF in chronically instrumented dogs.,
North American Society of Pacing and Electrophysiology 23rd Annual Scientific Sessions, San Diego, May 2002. Tomotsugu Tabata, RA Grimm, Y Kim, Hirotsugu Yamada, J Watanabe, NL Greenberg, DA Agler, Y Zhang, S Zhuang, DW Wallick, KA Mowrey, TN Mazgalev, T Oki and JD Thomas :
Benefit of Slowing the Ventricular Rate for Left Ventricular Systolic Performance During Atrial Fibrillation in Subjects With Myocardial Infarction.,
American College of Cardiology 51th Annual Scientific Session, Atlanta, Mar. 2002. Hirotsugu Yamada, E Donal, NL Greenberg, M Martin, DW Wallick, S Zhuang, Y Zhang, TE Mazgalev, JD Thomas and L Rodriguez :
Pulmonary Venous Atrial Systolic Flow Reversal Velocity During Ventricular Systole Predicts Left Atrial Elastance: A New Method for Assessing Left Atrial Systolic Function in an Animal Model.,
American College of Cardiology 51th Annual Scientific Session, Atlanta, Mar. 2002. Hirotsugu Yamada, Y Kim, Tomotsugu Tabata, NL Greenberg, E Donal, DA Agler, J Watanabe, Y Zhang, S Zhuang, KA Mowrey, TN Mazgalev, DW Wallick, DR Wagoner Van, JD Thomas and RA Grimm :
Correlation of Left Atrial Mechanical and Electrical Remodeling Following Short Duration Atrial Fibrillation.,
American College of Cardiology 51th Annual Scientific Session, Atlanta, Mar. 2002. Y Kim, Hirotsugu Yamada, Tomotsugu Tabata, J Watanabe, E Donal, DA Agler, S Zhuang, Y Zhang, DW Wallick, KA Mowrey, TN Mazgalev, JD Thomas and RA Grimm :
Left Atrial Reservoir and Active 'Pump' Function after Brief Duration of Atrial Fibrillation: An Acute Animal Study.,
American College of Cardiology 51th Annual Scientific Session, Atlanta, Mar. 2002. E Donal, Hirotsugu Yamada, NL Greenberg, DA Agler, Y Zhang, S Zhuang, DW Wallick, JD Thomas and L Rodriguez :
A new method for assessing left atrial systolic function during isovolumetric atrial contraction in the intact heart. An animal study.,
American College of Cardiology 51th Annual Scientific Session, Atlanta, Mar. 2002. E Donal, Hirotsugu Yamada, Y Kim, NL Greenberg, DA Agler, S Zhuang, Y Zhang, DW Wallick, KA Mowrey, TN Mazgalev, JD Thomas and RA Grimm :
Early Diastolic Mitral Annular Tissue Doppler Velocities Predicts the Degree of Left Atrial Appendage Stunning Following Conversion to Sinus Rhythm after Short Duration Atrial Fibrillation in a Canine Model.,
American College of Cardiology 51th Annual Scientific Session, Atlanta, Mar. 2002. Tomotsugu Tabata, T Oki, H Tanaka, Y Onose, M Matsuoka, T Tada, T Yamamoto, Tetsuzo Wakatsuki and Hirotsugu Yamada :
Myocardial Characterization of Cardiac Amyloidosis Using Myocardial Velocity Profile: Comparison With Hypertensive Heart Disease.,
American Heart Association's Scientific Sessions, Anaheim, Nov. 2001. Tomotsugu Tabata, T Oki, Y Onose, M Matsuoka, T Tada, T Yamamoto, Tetsuzo Wakatsuki and Hirotsugu Yamada :
Novel Strategy for Detecting Myocardial Viability by Evaluating Improvement of Early Diastolic Left Ventricular Asynchrony Using Dobutamine Stress Pulsed Tissue Doppler Imaging.,
American Heart Association's Scientific Sessions, Anaheim, Nov. 2001. Hirotsugu Yamada, M Jones, T Shiota, J Qin Xin, NL Greenberg, Y Kim, J Watanabe, LA Cardon, Y Abe, H Tsujino, R Kanda and JD Thomas :
Assessment of Nonuniformity of the Transmural Myocardial Velocity Profile by Angle Corrected Tissue Doppler Imaging: Characterization of Normal, Transmurally Infarcted and Nontrasmurally Infarcted Myocardium.,
American Heart Association's Scientific Sessions, Anaheim, Nov. 2001. J Watanabe, Tomotsugu Tabata, Hirotsugu Yamada and RA Grimm :
Rate Control During Atrial Fibrillation Improves Left Ventricular Relaxation Better Than Rhythm Regulation with Atrioventricular Node Ablation.,
American Heart Association's Scientific Sessions, Anaheim, Nov. 2001. Hirotsugu Yamada, T Oki, H Tanaka, M Matsuoka and T Tada :
The Role of Short and Long Axes Function for Determining Late Diastolic Left Vetrricular Filling in Patients with Hypertension.,
American Heart Association's Scientific Sessions, Anaheim, Nov. 2001. T Yamamoto, T Oki, Hirotsugu Yamada, H Tanaka, M Matsuoka, T Tada, Tetsuzo Wakatsuki and Tomotsugu Tabata :
Prognostic value of atrial systolic mitral annulus motion velocity in patients with dilated failing heart.,
American Society of Echocardiography 12th Annual Scientific Session, Seattle, Jun. 2001. H Tanaka, T Oki, Hirotsugu Yamada, Tetsuzo Wakatsuki, Tomotsugu Tabata, R Kanda, Y Abe and T Nabatame :
Early Diastolic Transmural Myocardial Velocity Profile Evaluated by Tissue Doppler Imaging in Normal Subjects and Patients With Left Ventricular Hypertrophy.,
American Society of Echocardiography 12th Annual Scientific Session, Seattle, Jun. 2001. Hirotsugu Yamada, T Oki, H Tanaka, Tetsuzo Wakatsuki, Tomotsugu Tabata, R Kanda, Y Abe and T Nabatame :
Accurate Measurement of Systolic Transmural Myocardial Velocity Profile Using Tissue Doppler Imaging in Normal Subjects And Patients with Hypertrophic Cardiomyopathy.,
American Society of Echocardiography 12th Annual Scientific Session, Seattle, Jun. 2001. Hirotsugu Yamada, T Oki, H Tanaka, M Matsuoka, T Yamamoto, T Tada, Tetsuzo Wakatsuki and Tomotsugu Tabata :
The Role of Short And Long Axes Function for Determining Late Diastolic Left Ventricular Filling in Patients with Hypertension: Assessment by Pulsed Tissue Doppler Imaging.,
American Society of Echocardiography 12th Annual Scientific Session, Seattle, Jun. 2001. Hirotsugu Yamada, T Oki, H Tanaka, M Matsuoka, T Yamamoto, T Tada, Tetsuzo Wakatsuki and Tomotsugu Tabata :
Potential Application of Tissue Doppler Imaging of the Left Ventricular Myocardium in Assessing Regional Diastolic Function in Patients with Hypertrophic Cardiomyopathy: Comparison with 1231-b-Methy1 Iodopheny1 Pentadecanoic Acid Myocardial Scintigraphy.,
American Society of Echocardiography 12th Annual Scientific Session, Seattle, Jun. 2001. Tomotsugu Tabata, TN Mazgalev, J Watanabe, Y Kim, NL Greenberg, Hirotsugu Yamada, DW Wallick, Y Zhang, S Zhuang, KA Mowrey, RA Grimm and JD Thomas :
Improvement in Left Ventricular Function during Atrial Fibrillation in Subjects with Myocardial Infarction Using Post-ganglionic Vagal Nerve Stimulation.,
NASPE 20th Annual Scientific Session, Boston, May 2001. Hirotsugu Yamada, T Oki, R Kanda, Y Abe and T Nabatame :
Accurate Measurement of Early Diastolic Transmural Myocardial Velocity Profile Using Tissue Doppler Imaging in Normal Subjects and Patients with Left Ventricular Hypertrophy.,
American College of Cardiology 50th Annual Scientific Session, Orlando, Mar. 2001. Hirotsugu Yamada, T Oki, Y Onose, M Matsuoka, T Yamamoto, Tomotsugu Tabata and Tetsuzo Wakatsuki :
Ultrasonic myocardial characterization of cardiac amyloidosis using tissue Doppler imaging.,
11th Annual Scientific Sessions American Society of Echocardiography, Chicago, Jun. 2000. M Matsuoka, T Oki, Y Mishiro, Hirotsugu Yamada, Y Onose, Tetsuzo Wakatsuki and Tomotsugu Tabata :
Quantitative assessment of left ventricular myocardial viability using systolic mitral annular descent velocity: A study with dobutamine stress pulsed tissue Doppler imaging.,
49th Annual Scientific Session of American College of Cardiology, Anaheim, Mar. 2000. Hirotsugu Yamada, M Matsuoka, T Oki, Y Mishiro, Y Onose, Tetsuzo Wakatsuki and Tomotsugu Tabata :
Quantitative assessment of left ventricular myocardial viability using systolic mitral annular descent velocity: A study with dobutamine stress pulsed tissue Doppler imaging.,
49th Annual Scientific Session of American College of Cardiology, Anaheim, Mar. 2000. Hirotsugu Yamada, T Oki, Y Mishiro, Y Onose, M Matsuoka, K Manabe, Y Kageji, Tetsuzo Wakatsuki, Y Oishi, Akiyoshi Nishikado and Susumu Ito :
Quantitative assessment of myocardial echo contrast using time-intensity curve.,
First International Kyoto Symposium on Ultrasound Contrast Imaging, Kyoto, Oct. 1999. Hirotsugu Yamada, T Oki, Y Mishiro, M Abe, Y Onose, Tomotsugu Tabata and Susumu Ito :
Myocardial gradient as an indicator of regional myocardial contraction after cardiac surgery: a study with tissue Doppler imaging.,
21st Congress of the European Society of Cardiology, Barcelona, Aug. 1999. Hirotsugu Yamada, T Oki, Y Mishiro, M Abe, Y Onose, Tomotsugu Tabata, Masahiro Nomura and Susumu Ito :
Regional left ventricular myocardial function in hypertrophic cardiomyopathy: assessment by tissue Doppler imaging and 123 I-b-methyliodopheny1 pentadecanoic acid scintigraphy.,
21st Congress of the European Society of Cardiology, Barcelona, Aug. 1999. Y Mishiro, T Oki, Hirotsugu Yamada, M Abe, Y Onose, Tomotsugu Tabata and Susumu Ito :
Assessment of left ventricular myocardial viability using mitral annular descent velocity: a study with dobutamine stress pulsed tissue Doppler imaging.,
21st Congress of the European Society of Cardiology, Barcelona, Aug. 1999. Hirotsugu Yamada, T Oki, Y Mishiro, M Abe, Y Onose and Tomotsugu Tabata :
Assessment of diastolic left ventricular myocardial velocity gradient in hypertrophic cardiomyopathy using tissue Doppler imaging: Comparison with 123I-BMIPP myocardial washout ratio.,
10th Annual Scientific Sessions American Society of Echocardiography, Washington, D.C., Jun. 1999. Tomotsugu Tabata, T Oki, Hirotsugu Yamada and JD Thomas :
Left ventricular subendocardial systolic velocity in dilated and hypertrophic cardiomyopathy: Pulsed tissue Doppler imaging of short and long axis motion.,
10th Annual Scientific Sessions American Society of Echocardiography, Washington, D.C., Jun. 1999. Y Mishiro, T Oki, Hirotsugu Yamada, M Abe, Y Onose and Tomotsugu Tabata :
Evaluation of left ventricular myocardial viability using mitral annular descent velocity: A study with dobutamine stress pulsed tissue Doppler imaging.,
10th Annual Scientific Sessions American Society of Echocardiography, Washington, D.C., Jun. 1999. Y Mishiro, T Oki, Hirotsugu Yamada, M Abe, Y Onose and Tomotsugu Tabata :
Mechanism of systolic left ventricular asynchrony in normal heart: A study with Angiotensin II stress pulsed tissue Doppler imaging.,
10th Annual Scientific Sessions American Society of Echocardiography, Washington, D.C., Jun. 1999. Y Mishiro, T Oki, A Iuchi, Hirotsugu Yamada, M Abe and Y Onose :
Global left ventricular systolic function in patients with hypertrophic cardiomyopathy: A study with low-dose angiotensin stress echocardiography.,
48th American College of Cardiology, New Orleans, Mar. 1999. Hirotsugu Yamada, Y Mishiro, T Oki, A Iuchi, M Abe and Y Onose :
Assessment of early diastolic left ventricular regional myocardial function in patients with hypertrophic cardiomyopathy using tissue Doppler imaging and magnetic resonance imaging with myocardial tagging.,
48th American College of Cardiology, New Orleans, Mar. 1999. Y Onose, T Oki, Tomotsugu Tabata, Y Mishiro, Hirotsugu Yamada, M Abe and A Iuchi :
Time relationship between left ventricular wall motion and transmitral flow velocities during early diastole.,
10th Congress of the International Cardiac Doppler Society, Kagawa, Nov. 1998. M Abe, T Oki, Tomotsugu Tabata, Y Mishiro, Hirotsugu Yamada, Y Onose and A Iuchi :
Differences in systolic and diastolic left ventricular wall motion velocities between aortic and mitral regurgitation evaluated by pulsed tissue Doppler imaging.,
10th Congress of the International Cardiac Doppler Society, Kagawa, Nov. 1998. Y Mishiro, T Oki, A Iuchi, Tomotsugu Tabata, Hirotsugu Yamada, M Abe, Y Onose, K Manabe, Y Kageji, K Fukuda, Susumu Ito, Y Taoka and Hiromu Nishitani :
Assessment of early diastolic left ventricular regional myocardial function in patients with hypertrophic cardiomyopathy using tissue Doppler imaging and magnetic resonance myocardial tagging.,
20th Congress of the European Society of Cardiology, Wien, Aug. 1998. Tomotsugu Tabata, T Oki, Hirotsugu Yamada, K Fukuda, M Abe, Y Onose, Tetsuzo Wakatsuki, H Fujinaga, K Sakabe, J Ikata, Akiyoshi Nishikado and A Iuchi :
Relationship between left atrial appendage function and plasma concentration of atrial natriuretic peptide.,
70th American Heart Asssociation, Orlando, Nov. 1997. Hirotsugu Yamada, T Oki, Tomotsugu Tabata, M Abe, K Manabe, K Fukuda, A Iuchi and Susumu Ito :
Evaluation of left atrial relaxation abnormality using pulmonary venous flow velocity and interatrial septal motion.,
19th Congress of the European Society of Cardiology, Stockholm, Aug. 1997. M Abe, T Oki, Tomotsugu Tabata, Hirotsugu Yamada, K Manabe, K Fukuda, A Iuchi and Susumu Ito :
Differentiation of left ventricular diastolic wall motion velocities between aortic and mitral regurgitation using tissue Doppler imaging.,
19th Congress of the European Society of Cardiology, Stockholm, Aug. 1997. K Fukuda, T Oki, Tomotsugu Tabata, K Manabe, Hirotsugu Yamada, M Abe, A Iuchi and Susumu Ito :
Relationship between left ventricular regional wall motion abnormalities and mitral annular descent velocities in patients with myocardial infarction and dilated cardiomyopathy: a study with tissue Doppler imaging.,
19th Congress of the European Society of Cardiology, Stockholm, Aug. 1997. Tomotsugu Tabata, T Oki, Hirotsugu Yamada, M Abe, K Manabe, K Fukuda, Tetsuzo Wakatsuki, K Sakabe, A Iuchi and Susumu Ito :
Relationship between left atrial appendage function and plasma concentration of artrial natriuretic peptide.,
19th Congress of the European Society of Cardiology, Stockholm, Aug. 1997. Hirotsugu Yamada, T Oki, Tomotsugu Tabata, K Manabe, K Fukuda, M Abe, A Iuchi, N Fukuda and Susumu Ito :
Evaluation of abnormal left ventricular wall motion velocity in congenital total absence of the left pericardium using myocardial velocity gradient obtained from tissue Doppler imaging.,
9th Meeting of the International Cardiac Doppler society, Rotterdam, Jun. 1997. A Iuchi, T Oki, Tomotsugu Tabata, K Manabe, K Fukuda, Hirotsugu Yamada, M Abe, N Fukuda and Susumu Ito :
Quantitative assessment of left ventricular wall motion velocities in normal and hypertensive hypertrophied hearts: application of two-dimensional vector concept by tissue Doppler imaging technique.,
9th Meeting of the International Cardiac Doppler society, Rotterdam, Jun. 1997. M Abe, T Oki, Tomotsugu Tabata, Hirotsugu Yamada, K Manabe, K Fukuda, A Iuchi, N Fukuda and Susumu Ito :
Evaluation of left ventricular wall motion characteristics in aortic regurgitation using tissue Doppler imaging.,
9th Meeting of the International Cardiac Doppler society, Rotterdam, Jun. 1997. Hirotsugu Yamada, T Oki, Tomotsugu Tabata, K Manabe, K Fukuda, M Abe, A Iuchi, N Fukuda and Susumu Ito :
Difference in systolic function velocity of the left ventricular posterior wall in patients with asymmetric septal hypertrophy and prior anteroseptal myocardial infarction.,
9th Meeting of the International Cardiac Doppler society, Rotterdam, Jun. 1997. Hirotsugu Yamada, T Oki, Tomotsugu Tabata, K Manabe, K Fukuda, M Abe, A Iuchi, N Fukuda and Susumu Ito :
Influence of aging on early diastolic and atrial systolic motion dynamics of the left ventricular wall in normal subjects: Vector analysis of the wall motion velocities using pulsed tissue Doppler imaging.,
8th Annual Scientific American Society of Echocardiography, Orlando, Jun. 1997. Tomotsugu Tabata, T Oki, Hirotsugu Yamada, K Manabe, K Fukuda, M Abe, A Iuchi, N Fukuda and Susumu Ito :
Evaluation of left ventricular regional systolic wall motion velocity in hypertrophied heart using pulsed tissue Doppler imaging.,
8th Annual Scientific Sessions American Society of Echocardiography, Orlando, Jun. 1997. Tomotsugu Tabata, T Oki, Hirotsugu Yamada, K Manabe, K Fukuda, M Abe, A Iuchi, N Fukuda and Susumu Ito :
Evaluation of left atrial relaxation abnormality using pulmonary venous flow velocity and interatrial septal motion.,
8th Annual Scientific Sessions American Society of Echocardiography, Orlando, Jun. 1997. T Oki, Tomotsugu Tabata, Hirotsugu Yamada, K Manabe, K Fukuda, M Abe, A Iuchi, N Fukuda and Susumu Ito :
Evaluation of electrical and mechanical discordance during atrial systole using pulsed tissue Doppler imaging.,
8th Annual Scientific Sessions American Society of Echocardiography, Orlando, Jun. 1997. M Abe, T Oki, Tomotsugu Tabata, K Manabe, K Fukuda, Hirotsugu Yamada, A Iuchi and Susumu Ito :
Differentiation of left ventricular diastolic wall motion velocities between aortic and mitral regurgitation using tissue Doppler imaging.,
The 7th Asian-Pacific Conference on Doppler and Echocardiography, Osaka, May 1997. Tomotsugu Tabata, T Oki, Hirotsugu Yamada, K Manabe, K Fukuda, M Abe, A Iuchi and Susumu Ito :
Evaluation of left atrial and ventricular mechanical discordance during atrial systole in various heart diseases using pulsed tissue Doppler imaging.,
The 7th Asian-Pacific Conference on Doppler and Echocardiography, Osaka, May 1997. Hirotsugu Yamada, T Oki, Tomotsugu Tabata, K Fukuda, K Manabe, M Abe, A Iuchi and Susumu Ito :
Assessment of left ventricular systolic wall motion velocity using pulsed tissue Doppler imaging: Comparison with dP/dt of left ventricular pressure curve.,
The 7th Asian-Pacific Conference on Doppler and Echocardiography, Osaka, May 1997. T Oki, Tomotsugu Tabata, Hirotsugu Yamada, Tetsuzo Wakatsuki, H Shinohara, Akiyoshi Nishikado, A Iuchi, N Fukuda and Susumu Ito :
Clinical application of pulsed Doppler tissue imaging for assessing abnormal relaxation of the left ventricle.,
69th American Heart Association, New Orleans, Nov. 1996. Tomotsugu Tabata, Takashi Oki, Hirotsugu Yamada, Arata Iuchi, Takaki Hori, Tetsuya Kitagawa, Kato Itsuo, Hiroshi Kitahata, Shuzo Oshita and Susumu Ito :
Roles of left atrial appendage for left atrial hemodynamics by left atrial appendage clamping durig cardiac surgery.,
69th American Heart Association, New Orleans, Nov. 1996. Hirotsugu Yamada, T Oki, Tomotsugu Tabata, K Manabe, K Fukuda, M Abe, A Iuchi, Akiyoshi Nishikado, Tetsuzo Wakatsuki, K Sakabe, J Ikata and Susumu Ito :
Assessment of myocardial circumferential shorttening of the left ventricular wall using pulsed Doppler tissue imaging.,
69th American Heart Association, New Orleans, Nov. 1996. T Oki, A Iuchi, Tomotsugu Tabata, Hirotsugu Yamada, Akiyoshi Nishikado, Tetsuzo Wakatsuki, H Shinohara, N Fukuda and Susumu Ito :
Non-invasive assessment of left ventricular relaxation by pulsed Doppler tissue imaging: comparison with cardiac catheterization.,
18th Congress of the European Society of Cardiology, Birmingham, Aug. 1996. Tomotsugu Tabata, T Oki, A Iuchi, Hirotsugu Yamada, K Manabe, K Fukuda, M Sasaki, N Fukuda and Susumu Ito :
Evaluation of left ventricular diastolic function in hypertrophied hearts using Doppler tissue imaging.,
18th Congress of the European Society of Cardiology, Birmingham, Aug. 1996. Tomotsugu Tabata, T Oki, A Iuchi, Hirotsugu Yamada, K Manabe, M Sasaki, K Kawahara, T Niki, N Fukuda and Susumu Ito :
Evaluation of left ventricular diastolic function in hypertrophied hearts using Doppler tissue imaging.,
7th American Society of Echocardiography, Chicago, Jun. 1996. K Sakabe, Tetsuzo Wakatsuki, H Shinohara, Akiyoshi Nishikado, Hirotsugu Yamada, Tomotsugu Tabata, A Iuchi, T Oki and Susumu Ito :
Coronary flow velocity immediately after reperfusion reflects myocardial microcirculation in canine acute myocardial infarction models.,
45th American College of Cardiology, Orlando, Mar. 1996. Tomotsugu Tabata, T Oki, A Iuchi, K Manabe, M Sasaki, Hirotsugu Yamada, N Fukuda and Susumu Ito :
Influence of left atrial pressure on the left atrial appendage flow velocity pattern.,
45th American College of Cardiology, Orlando, Mar. 1996. Tomotsugu Tabata, T Oki, A Iuchi, Hirotsugu Yamada and Susumu Ito :
Evaluation of left ventricular diastolic function in hypertrophied hearts using Doppler tissue imaging.,
5th Antwerp-La Jolla-Kyoto Research Conference on Cardiac function, Kyoto, Dec. 1995. Hirotsugu Yamada, T Oki, A Iuchi, Tomotsugu Tabata and Susumu Ito :
Changes with age in the left ventricular wall motion velocity patterns in normal subjects: A study with pulsed Doppler tissue imaging.,
5th Antwerp-La Jolla-Kyoto Research Conference on Cardiac function, Kyoto, Dec. 1995. N Fukuda, T Oki, A Iuchi, Tomotsugu Tabata, K Manabe, Y Kageji, M Sasaki, Hirotsugu Yamada and Susumu Ito :
Effect of left atrial pressure on the rate of left ventricular relaxation estimated by mitral regurgitant flow velocity using continuous wave Doppler echocardiography in dilated heart.,
17th Congress of the European Society of Cardiology, Amsterdam, Aug. 1995. T Oki, A Iuchi, M Sasaki, Tomotsugu Tabata, Y Kageji, K Manabe, Hirotsugu Yamada, N Fukuda and Susumu Ito :
Transesophageal pulsed Doppler echocardiographic evaluation of left atrial systolic performance in hypertrophic cardiomyopathy.,
17th Congress of the European Society of Cardiology, Amsterdam, Aug. 1995. Hirotsugu Yamada, T Oki, Tomotsugu Tabata, N Fukuda, A Iuchi, K Manabe, Y Kageji, M Sasaki and Susumu Ito :
Influence of aging on left atrial appendage flow velocity pattern in healthy subjects with sinus rhythm: a study with transesophageal pulsed Doppler echocardiography.,
17th Congress of the European Society of Cardiology, Amsterdam, Aug. 1995. Tomotsugu Tabata, T Oki, N Fukuda, A Iuchi, K Manabe, Y Kageji, M Sasaki, Hirotsugu Yamada and Susumu Ito :
Influence of left atrial pressure on the left atrial appendage flow velocity pattern in myocardial diseases with sinus rhythm.,
17th Congress of the European Society of Cardiology, Amsterdam, Aug. 1995. Hirotsugu Yamada, T Oki, N Fukuda, A Iuchi, Tomotsugu Tabata, K Manabe, Y Kageji and M Sasaki :
Influence of left atrial pressure on the left atrial appendage flow velocity pattern.,
8th Congress of the International Cardiac Doppler Society, Sapporo, Jul. 1995. A Iuchi, T Oki, N Fukuda, Tomotsugu Tabata, K Manabe, Y Kageji, M Sasaki, Hirotsugu Yamada, K Kawahara and T Niki :
Evaluation of left ventricular diastolic performance in hypertrophied heart by Doppler tissue imaging: Measurement of mitral annular velocities.,
8th Congress of the International Cardiac Doppler Society, Sapporo, Jul. 1995. Tomotsugu Tabata, T Oki, N Fukuda, A Iuchi, K Manabe, Y Kageji, M Sasaki, Hirotsugu Yamada, K Kawahara and T Niki :
Quantitative assessment of left ventricular wall motion abnormalities in hypertrophied heart using Doppler tissue imaging system.,
8th Congress of the International Cardiac Doppler Society, Sapporo, Jul. 1995. T Oki, N Fukuda, A Iuchi, Tomotsugu Tabata, K Manabe, Y Kageji, M Sasaki, Hirotsugu Yamada and Susumu Ito :
Left atrial systolic performance in the presence of elevated left ventricular end-diastolic pressure: Evaluation by transesophageal pulsed Doppler echocardiography of left ventricular inflow and pulmonary venous flow velocities.,
3rd International Congress on Heart Failure, Geneva, May 1995. R Bando, Koji Yamaguchi, Tetsuzo Wakatsuki, Takayuki Ise, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Predictors of late lumen enlargement after drug coated balloon angioplasty for denovo coronary lesions,
ACC 2024, Atlanta, Apr. 202. 伊藤直司, 八木秀介, 佐田政隆, 若槻哲三, 添木武, 山田博胤, 山口浩司, 高橋智子, 手束一貴, 松浦朋美 :
ペースメーカー電池交換術後に発症した血管性浮腫の1例,
第131回日本内科学会四国地方会, 2024年12月. Tserensonom Munkhtsetseg, 八木秀介, 伊勢孝之, 川端豊, 門田宗之, 山口浩司, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
経カテーテル的大動脈弁置換術後血清Lp【a】の上昇は予後不良のリスクファクター,
第45回日本循環制御医学会総会・学術集会, 2024年6月. 西條良仁, 山田博胤, Zheng Robert, 髙橋智紀, 坂東遼, 高橋智子, 原知也, 門田宗之, 川端豊, 上野理絵, 松浦朋美, 伊勢孝之, 山口浩司, 八木秀介, 添木武, 若槻哲三, 笹聡一郎, 滝沢宏光, 佐田政隆 :
Mechanical circulatory supportを要した重症がん治療関連心機能障害の1例,
第124回日本循環器学会中国・四国合同地方会, 2024年6月. 八木一成, 八木秀介, 西條良仁, 高橋智子, Zheng Robert, 坂東遼, 髙橋智紀, 原知也, 門田宗之, 川端豊, 上野理絵, 松浦朋美, 伊勢孝之, 山口浩司, 山田博胤, 添木武, 若槻哲三, 佐田政隆, 秦広樹, 菅野幹雄 :
心室中隔欠損症・感染性心内膜炎を合併した大動脈縮窄証による二次性高血圧症の一例,
第124回日本循環器学会中国・四国合同地方会, 2024年6月. 西條良仁, 山田博胤, Robert ZHENG, 髙橋智紀, 山口夏美, 平田有紀奈, 西尾進, 佐田政隆 :
AL および TTR アミロイドーシスにおける心エコー所見の相違に関する検討,
第97回日本超音波医学会学術集会, 2024年5月. 山口夏美, 西尾進, 髙橋智子, 野村侑香, 平田有紀奈, Robert ZHENG, 髙橋智紀, 西條良仁, 山田博胤, 佐田政隆 :
左房内膜肉腫の 1 例,
第97回日本超音波医学会学術集会, 2024年5月. 生田航大, 芥川正武, 榎本崇宏, 木内陽介, 北岡和義, 山田博胤, 田中弘之 :
CNNを用いた総頸動脈血流速度分布と動脈硬化症の関連性の検討,
第63回日本生体医工学会大会抄録集, 314, 2024年5月.

(要約): アテローム性動脈硬化症は循環系疾患の危険因子の 1 つであり，動脈硬化症は肥満・喫煙・運動不足や生活習慣病によって進行する．現在では動脈硬化症の検査方法の一つとして，超音波エコー画像で評価する頸動脈超音波検査がある．しかし，測定・評価にはある程度の専門知識が必要になる．そこで本研究グループでは，容易に測定可能な小型のスクリーニングデバイスとして頸動脈血流速度測定装置の開発に取り組んでいる．総頸動脈における血流速度の時間変化 ( 以後，総頸動脈血流速度波形と記す ) の数値シミュレーションを行った結果，動脈弾性が変化すると総頸動脈血流速度波形には違いが現れることが示されている．しかし，総頸動脈における血流速度分布の時間変化 ( 以後，総頸動脈血流速度分布と記す ) と動脈硬化症の関連性については，まだ十分に明らかになっていない．そこで，頸動脈血流速度測定装置の試作機で測定された健常者と動脈硬化症患者の総頸動脈血流速度分布の比較を行った．測定された血流速度分布を学習データとして畳み込みニューラルネットワークを用い，健常者と動脈硬化症患者に分類した．その結果，総頸動脈血流速度波形の特徴量を用いて分類を行った結果より，正確率は向上した．今後は，両者間の違い・特徴を明らかにしていきたい．

平田有紀奈, 野村侑香, 山口夏美, 西尾進, Robert Zheng, 髙橋智紀, 西條良仁, 山田博胤, 佐田政隆, 楠瀬賢也 :
心臓超音波検査における全自動解析システムによる精度と時間短縮の検証,
第35回日本心エコー図学会学術集会, 2024年4月. 西條良仁, 楠瀬健也, 髙橋智紀, 山田博胤, 佐田政隆, 佐藤希美, Noor Albakaa, 石津智子, 瀬尾由広 :
経カテーテル的大動脈弁置換術における混合型」大動脈弁疾患の左室形状と予後への影響:多施設共同研究からの知見,
第35回日本心エコー図学会学術集会, 2024年4月. 野村侑香, 平田有紀奈, 山口夏美, 森田沙瑛, 西尾進, Zheng Robert, 髙橋智紀, 西條良仁, 山田博胤, 佐田政隆, 楠瀬賢也 :
心臓超音波検査における全自動解析システムを用いた左室・左房ストレインの計測精度に関する検討,
第88回日本循環器学会学術集会, 2024年3月. Ryo Bando, Koji Yamaguchi, Tetsuzo Wakatsuki, Yutaka Kawabata, TOMONORI Takahashi, Hayato Orino, Issei Yagi, TOMONORI Takahashi, Zheng Robert, Yoshihito Saijyo, Tomoya Hara, Muneyuki Kadota, Tomomi Matsuura, Takayuki Ise, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Predictors of Late Lumen Enlargement after Drug Coated Balloon Angioplasty for de Novo Coronary Lesions,
第88回日本循環器学会学術集会 JCS2024, Mar. 2024. Yoshihito Saijyo, Hirotsugu Yamada, 長野絋平, 折野逸人, 八木一成, TAKAHASHI Tomoko, Zengu Robahto, BANDO Ryo, TOMONORI Takahashi, Tomoya Hara, Muneyuki Kadota, Yutaka Kawabata, Tomomi Matsuura, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Incremental Value of Relative Apical Sparing Index for Discrimination of Cardiac Amyloidosis Subtypes,
第88回日本循環器学会学術集会, Mar. 2024. 平田有紀奈, 野村侑香, 山口夏美, 西尾進, Robert Zheng, 髙橋智紀, 西條良仁, 山田博胤, 佐田政隆, 楠瀬賢也 :
心臓超音波検査における全自動解析システムの可能性,
第88回日本循環器学会学術集会, 2024年3月. M Tserensonom, Shusuke Yagi, Takayuki Ise, Yutaka Kawabata, Muneyuki Kadota, Tomoya Hara, Kenya Kusunose, Koji Yamaguchi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
High Serum lipoprotein (a) level is a risk factor of poor prognosis after transcatheter aortic valve implantation,
第88回日本循環器学会学術集会 JCS2024, Mar. 2024. 八木一成, 西條良仁, 長野絋平, 折野逸人, 吉田直史, 髙橋智子, Robert Zheng, 坂東遼, 髙橋智紀, 原知也, 門田宗之, 川端豊, 松浦朋美, 伊勢孝之, 山口浩司, 八木秀介, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
ALおよびATTR心アミロイドーシス間のエコー図検査的特徴の相違に関する検討,
第123回日本循環器学会四国支部地方会, 2023年12月. 髙橋智紀, 林修司, 山口夏美, 森田沙瑛, 平田有紀奈, 西尾進, Robert Zheng, 西條良仁, 山田博胤, 佐田政隆 :
3次元経食道超音波時代におけるランブル疣贅の頻度と形態評価,
第33回日本超音波産学会四国地方会学術集会, 2023年10月. 野中蓮, 西尾進, 平田有紀奈, 野村侑香, 山口夏美, 森田沙瑛, 西條良仁, 楠瀬賢也, 山田博胤, 佐田政隆 :
RAWデータおよびDICOMデータにおけるストレイン解析の差異に関する検討,
第33回日本超音波産学会四国地方会学術集会, 2023年10月. 平田有紀奈, 楠瀬賢也, 山口夏美, 森田沙瑛, 湯浅麻美, 松本力三, 西尾進, Robert Zheng, 髙橋智紀, 西條良仁, 山田博胤, 佐田政隆 :
上腕動脈における血管柔軟性と性差・加齢との関係 ∼ViewWaveを用いた検討∼,
第71回日本心臓病学会学術集会，2023年9月8日(金)∼10日(日)，東京, 2023年9月. 西尾進, 楠瀬賢也, 野村侑香, 山口夏美, 湯浅麻美, 松本力三, 平田有紀奈, Robahto Zengu, 髙橋智紀, 西條良仁, 山田博胤, 佐田政隆 :
HFpEFに対する脈波増大指数の影響∼SphygmoCor-XCEL®を用いた検討∼,
第71回日本心臓病学会学術集会, 2023年9月. 松本力三, 西尾進, 大豆本圭, 森田沙瑛, 湯浅麻美, 平田有紀奈, 山尾雅美, 齋藤裕, 楠瀬賢也, 山田博胤, 島田光生, 佐田政隆 :
後腹膜リンパ節転移を生じたBurned-out testicular tumorの1例,
第48回日本超音波検査学会学術集会, 2023年6月. 森田沙瑛, 西尾進, 松本力三, 山口夏美, 湯浅麻美, 平田有紀奈, 山尾雅美, 齋藤裕, 楠瀬賢也, 山田博胤, 島田光生, 佐田政隆 :
分枝膵管型IPMNに由来した膵管内乳頭粘液性腺癌の一例,
第48回日本超音波検査学会学術集会, 2023年6月. 平田有紀奈, 西尾進, 岩本紗英, 野村侑香, 山口夏美, 森田沙瑛, 湯浅麻美, 松本力三, 山尾雅美, 楠瀬賢也, 山田博胤, 佐田政隆 :
検査経験別にみた2次元および3次元超音波による測定精度の比較,
第48回日本超音波検査学会学術集会, 2023年6月. 山口夏美, 西尾進, 平田有紀奈, 野村侑香, 森田沙瑛, 湯浅麻美, 松本力三, 髙橋智紀, 西條良仁, 楠瀬賢也, 山田博胤, 佐田政隆 :
コロナウイルス感染後に左室心筋に高度の石灰化をきたした1例,
第48回日本超音波検査学会学術集会, 2023年6月. 西尾進, 楠瀬賢也, 平田有紀奈, 山口夏美, Robert Zheng, 髙橋智紀, 瀬野弘光, 西條良仁, 山田博胤, 佐田政隆 :
マルチモダリティによる心筋ストレイン評価,
第48回日本超音波検査学会学術集会, 2023年6月. 山田博胤, 楠瀬賢也, 西尾進, 佐田政隆 :
卒前・卒後の超音波研修:医師の超音波離れをどうするか．徳島大学病院の卒後研修プログラムにおける超音波研修,
第96回日本超音波医学会学術集会, 2023年5月. 山口夏美, 山田博胤, 門田宗之, 森田沙瑛, 平田有紀奈, 西尾進, 髙橋智紀, 西條良仁, 楠瀬賢也, 佐田政隆 :
心サルコイドーシスとの鑑別に苦慮した巨細胞性心筋炎の1 例,
第96回日本超音波医学会学術集会, 2023年5月. 平田有紀奈, 山田博胤, 山口夏美, 森田沙瑛, 湯浅麻美, 松本力三, 山尾雅美, 西尾進, 楠瀬賢也, 佐田政隆 :
Point-of-Care の心臓超音波検査(FoCUS)の普及に向けて．当院における技師による簡易エコー(POCUS)の取り組み,
第96回日本超音波医学会学術集, 2023年5月. 平田有紀奈, 山田博胤, 山口夏美, 森田沙瑛, 西尾進, 髙橋智紀, 西條良仁, 楠瀬賢也, 添木武, 佐田政隆 :
マラソンと左房機能:スポーツ後の Cardiac fatigue とは,
96回日本超音波医学会学術集会, 2023年5月. 髙橋智紀, 楠瀬賢也, 岩野弘幸, 柴山謙太郎, 北井豪, 田中秀和, 山田博胤, 佐田政隆 :
急性心不全における非侵襲的Forrester分類の臨床的有用性,,
第34回日本心エコー図学会学術集会, 2023年4月. 髙橋智紀, 山田博胤, 和田靖明, 衣川尚知, 木村靖子, 野坂淳子, 井伊稚佳子, 米山里果, 内海郁恭, 楠瀬賢也, 佐田政隆 :
心不全ステージAの糖尿病患者における糖尿病性心筋症とその臨床背景および心エコー図指標に関する検討,
第37回日本心エコー図学会学術集会, 2023年4月. 西條良仁, 楠瀬賢也, 山田博胤, Robert Zheng, 瀬野弘光, 髙橋智紀, 西尾進, 平田有紀奈, 森田沙瑛, 山口夏美, 佐田政隆 :
心房細動患者において心機能が左房憩室に与える影響の検討,
第37回日本心エコー図学会学術集会, 2023年4月. Zengu Robahto, Muneyuki Kadota, Keita Ohtani, Hayato Orino, Yusuke Negishi, Tomoko Takahashi, Ryo Bando, Hiromitsu Seno, TOMONORI Takahashi, Yoshihito Saijyo, Yutaka Kawabata, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Koji Yamaguchi, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
A Case of Biopsy-Proven Giant Cell Myocarditis,
第37回日本心エコー図学会学術集会, Apr. 2023. 平田有紀奈, 西尾進, 楠瀬賢也, 山田博胤, 佐田政隆 :
ストレイン法を加えると，何がわかりますか?,
第37回日本心エコー図学会学術集会, 2023年4月. 西條良仁, 楠瀬賢也, 山田博胤, 瀬野弘光, 髙橋智紀, Robert Zheng, 西尾進, 平田有紀奈, 森田沙瑛, 山口夏美, 佐田政隆 :
Mixed aortic valve diseaseにおいて中等度以上の大動脈弁膜症の併存が左室形態および予後に与える影響の検討,
第37回日本心エコー図学会学術集会, 2023年4月. 山田博胤, 大櫛祐一郎, 楠瀬賢也, ゼングローバート, 髙橋智紀, 西條良仁, 西尾進, 平田有紀奈, 添木武, 佐田政隆 :
乳癌の薬物療法における心エコー図検査を用いた心毒性サーベイランスの有用性,
第37回日本心エコー図学会学術集会, 2023年4月. 湯浅麻美, 西尾進, 山口夏美, 森田沙瑛, 松本力三, 平田有紀奈, 山尾雅美, Robert Zheng, 大櫛祐一郎, 瀬野弘光, 髙橋智紀, 西條良仁, 楠瀬賢也, 山田博胤, 佐田政隆 :
ヘルスクロノスを用いた冠動脈狭窄検出の試み,
第8回日本血管不全学会学術集会, 2023年4月. 西尾進, 楠瀬賢也, 平田有紀奈, 山口夏美, Robert Zheng, 髙橋智紀, 瀬野弘光, 西條良仁, 山田博胤, 佐田政隆 :
心エコー図検査における2Dストレイン計測の現状と課題,
第87回日本循環器学会学術集会, 2023年3月. Ryo Bando, Tetsuzo Wakatsuki, Koji Yamaguchi, Yutaka Kawabata, Ryota Miyamoto, Zengu Robahto, TOMONORI Takahashi, Yoshihito Saijyo, Rie Ueno, Muneyuki Kadota, Tomoya Hara, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Two-year Outcomes of Drug-coated Balloon-only Strategy for De Novo Lesions in Large Coronary Vessels,
第87回日本循環器学会学術集会, Mar. 2023. Yoshihito Saijyo, Yuichiro Okushi, Kenya Kusunose, Hirotsugu Yamada, Zengu Robahto, TOMONORI Takahashi, Hiromitsu Seno, Susumu Nishio, Rie Ueno, Muneyuki Kadota, Tomoya Hara, Yutaka Kawabata, Tomomi Matsuura, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Utility of Periodic Echocardiographic Surveillance for Early Detection of Cardiac Dysfunction from Chemotherapy in Breast Cancer Patients,
第87回日本循環器学会学術集会, Mar. 2023. Yutaka Kawabata, Tetsuzo Wakatsuki, Koji Yamaguchi, BANDO Ryo, Yoshihito Saijyo, Rie Ueno, Muneyuki Kadota, Tomoya Hara, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
The Impact of Coronary Plaque Progression Stage on Coronary Neovascularization Structures in Fresh Cadavers,
第87回日本循環器学会学術集会, Mar. 2023. Takayuki Ise, Shusuke Yagi, Rie Ueno, Muneyuki Kadota, Keita Ohtani, Yusuke Negishi, Ryota Miyamoto, BANDO Ryo, Zengu Robahto, Hiromitsu Seno, TOMONORI Takahashi, Yutaka Kawabata, Yoshihito Saijyo, Tomomi Matsuura, Kenya Kusunose, Koji Yamaguchi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Novel Home-based Cardiac Telerehabilitation System Using a Wearable Device and a Web Application,
第87回日本循環器学会学術集会, Mar. 2023. S Yamaguchi, M Maeda, K Ohba, M Glinu, O Arasaki, Shusuke Yagi, Kenya Kusunose, Takeshi Soeki, Hirotsugu Yamada, Daiju Fukuda, H Masuzaki, Masataka Sata and Michio Shimabukuro :
Sex Differences in the Association between Epicardial Adipose Tissue Volume and Left Atrial Volume Index,
第87回日本循環器学会学術集会, Mar. 2023. 吉田知哉, 伊勢孝之, 宮本亮太, 坂東遼, Robert Zheng, 瀬野弘光, 高橋智紀, 川端豊, 松浦朋美, 西條良仁, 門田宗之, 楠瀬賢也, 添木武, 山口浩司, 八木秀介, 山田博胤, 若槻哲三, 飯間努, 山本浩史, 佐田政隆 :
劇症型心筋炎に対してECPELLA導入で救命しえた症例,
第121回日本循環器学会四国地方会, 2022年12月. 高橋智紀, 楠瀬賢也, Robert Zheng, 瀬野弘光, 西條良仁, 門田宗之, 川端豊, 松浦朋美, 伊勢孝之, 山口浩司, 八木秀介, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
心房細動患者におけるイソプロテレノール負荷経食堂心エコー図法の有用性,
第121回日本循環器学会四国地方, 2022年12月. 野村侑香, 西尾進, 平田有紀奈, 山尾雅美, 山口夏美, 森田沙瑛, 西條良仁, 楠瀬賢也, 山田博胤, 佐田政隆 :
RAW data と DICOM data で計測した左室長軸方向ストレイン値の差異,
第32回日本超音波医学会四国地方会学術集会, 2022年10月. 森田沙瑛, 西尾進, 湯浅麻美, 松本力三, 平田有紀奈, 山尾雅美, 楠瀬賢也, 山田博胤, 菅野幹雄, 佐田政隆 :
無症状で経過した VSD 合併バルサルバ洞動脈瘤破裂の一例,
第32回日本超音波医学会四国地方会学術集会, 2022年10月. 折野逸人, 西條良仁, 楠瀬賢也, Zheng Robert, 高橋智紀, 瀬野弘光, 山尾雅美, 西尾進, 山田博胤, 佐田政隆 :
心房細動患者における左房憩室の頻度および形態学的特徴に関する検討,
第32回日本超音波医学会四国地方会学術集会, 2022年10月. 吉田知哉, 若槻哲三, 山木浩二, 西條良仁, 川端豊, 伊勢孝之, 楠瀬賢也, 八木秀介, 山田博胤, 添木武, 佐田政隆 :
冠動脈入口部および鎖骨下動脈に特徴的な血管内超音波所見を認めた高安動脈炎の2例,
第70回日本心臓病学会学術集会, 2022年9月. 大櫛祐一郎, 楠瀬賢也, 瀬野弘光, 高橋智紀, 西條良仁, 伊勢孝之, 山口浩司, 八木秀介, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
心エコー検査によるサーベイランスのがん治療関連心筋障害への影響,
第5回日本腫瘍循環器学会学術集会, 2022年9月. 松崎慶仁, 西條良仁, 伊勢孝之, 太田啓太, 折野逸人, 吉田知哉, 根岸佑典, 宮本亮太, 坂東遼, Rovert Zheng, 瀬野弘光, 高橋智紀, 上野理絵, 門田宗之, 原知也, 川端豊, 松浦朋美, 楠瀬賢也, 山口浩司, 八木秀介, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
急性A型大動脈解離をきたしたMarfan症候群の一例,
第265回徳島県医学学術集会, 2022年7月. 根岸佑典, 門田宗之, 山口浩司, 山田博胤, 折野逸人, 太田啓太, 吉田知哉, 宮本亮太, 坂東遼, Robert Zheng, 瀬野弘光, 高橋智紀, 西條良仁, 上野理絵, 原知也, 川端豊, 松浦朋美, 伊勢孝之, 楠瀬賢也, 八木秀介, 添木武, 若槻哲三, 田蒔昌憲, 佐田政隆 :
腎動脈拡張術により心不全の著名な改善を認めたCardiac Disturbance syndrome の1例,
第265回徳島県医学学術集会, 2022年7月. 八木秀介, 伊勢孝之, 門田宗之, 川端豊, 原知也, 上野理絵, 西條良仁, 松浦朋美, 楠瀬賢也, 山口浩司, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
パンデミック下の臨床実習におけるオンライン医学教育の実際と問題点,
第265回徳島県医学学術集会, 2022年6月. 北村彩乃, 大南博和, 増田真志, 奥村仙示, 伊勢孝之, 八木秀介, 福田大受, 山田博胤, 佐田政隆, 竹谷豊 :
運動介入中の脂質摂取の違いが心不全マウスの病態に及ぼす影響,
第28回日本心臓リハビリテーション学会学術集会, 2022年6月. 伊勢孝之, 石井亜由美, 西川幸治, 門田宗之, 八木秀介, 山田博胤, 竹谷豊, 佐田政隆 :
Withコロナに対応した心リハオンライン臨床実習システムの構築,
第28回日本心臓リハビリテーション学術集会, 2022年6月. 高橋里加子, 門田宗之, 伊勢孝之, 西條良仁, 川端豊, 松浦朋美, 楠瀬賢也, 山口浩司, 八木秀介, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
免疫抑制療法の導入により心機能が劇的に改善した巨細胞性心筋炎の一例,
第120回日本循環器学会中国・四国合同地方会, 2022年5月. 門田宗之, 楠瀬賢也, 八木秀介, 川端豊, 西條良仁, 松浦朋美, 伊勢孝之, 山口浩司, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
慢性心不全におけるサクビトリル / バルサルタンのナトリウム利尿ペプチドに対する急性反応の検討,
第120回日本循環器学会中国・四国合同地方会, 2022年5月. 髙坂佳孝, 楠瀬賢也, 芳賀昭宏, 山口夏美, 竹田泰治, 田中秀和, 三宅誠, 森内健史, 山田博胤, 佐田政隆 :
人工知能による左室駆出率予測モデルの施設間差についての検討,
日本超音波医学会第95回学術集会, 2022年5月. 楠瀬賢也, 山田博胤, 佐田政隆 :
心毒性を有する薬物投与時の心機能評価,
日本超音波医学会第95回学術集会, 2022年5月. 西條良仁, 山田博胤, 楠瀬賢也, 瀬野弘光, 高橋智紀, 山口夏美, 森田沙瑛, 平田有紀奈, 西尾進, 佐田政隆 :
心エコー図検査を用いたがん治療関連心機能障害サーベイランス,
日本超音波医学会第95回学術集会, 2022年5月. 楠瀬賢也, 山田博胤, 若槻哲三, 佐田政隆 :
大動脈弁閉鎖不全症の評価法,
第32回日本心血管画像動態学会, 2022年5月. ツェレンソノムムンフツェツェゲ, 八木秀介, 伊勢孝之, 福田大受, 門田宗之, 川端豊, 楠瀬賢也, 山口浩司, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
動脈硬化性疾患の高リスク患者において大動脈弁の石灰化と血清リポ蛋白との関連,
第9回日本心血管脳卒中学会学術集会, 2022年4月. Y Saijo, Kenya Kusunose, Yuichiro Okushi, Hirotsugu Yamada and Masataka Sata :
Predictive Value of Speckle Tracking Echocardiography for Cancer Therapy Related Cardiac Dysfunction,
第86回日本循環器学会学術集会, Mar. 2022. Y Okushi, Kenya Kusunose, Zheng Robert, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Findings from the JROAD-DPC Registry across 6 Studies Conducted in a Year,
第86回日本循環器学術集会, Mar. 2022. Kenya Kusunose, Hirotsugu Yamada and Masataka Sata :
Artificial Intelligence in Echocardiography, Special Session12 Artificial Intelligence in Cardiology,
第86回日本循環器学会学術集会, Mar. 2022. Yutaka Kawabata, Tetsuzo Wakatsuki, Koji Yamaguchi, Daiju Fukuda, Yoshihito Saijyo, Muneyuki Kadota, Tomomi Matsuura, 伊勢孝之, Kenya Kusunose, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
First Assessment of Coronary Plaque Vulnerability and Lipid Core Burden Assessed by Near-Infrared Spectroscopy-Intravascular Ultrasound in a Fresh Cadaver,
第86回日本循環器学会学術集会, Mar. 2022. 山口夏美, 楠瀬賢也, 芳賀昭弘, 平田有紀奈, 西尾進, 山田博胤, 佐田政隆 :
人工知能を用いた左室壁運動異常の検出,
第86回日本循環器学会学術集会, 2022年3月. Kenya Kusunose, Hirotsugu Yamada and Masataka Sata :
Clinical Utility of Stress Echocardiography in Pulmonary Hypertension,
第86回日本循環器学会学術集会, Mar. 2022. Tomonori Takahasi, Kenya Kusunose, Yukina Hirata, Susumu Nisio, Yuichiro Okushi, Hiromitsu Seno, Y Saijo, Muneyuki Kadota, Yutaka Kawabata, Tomomi Matsuura, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Cardiovascular Risk Factors Associated with Left Ventricular Strain Distribution in Patients without Known Cardiovascular Disease,
第86回日本循環器学会学術集会, Mar. 2022. 平田由紀奈, 楠瀬賢也, 辻拓将, 古徳純一, 西尾進, 山田博胤, 佐田政隆 :
胸部X線画像に人工知能を組み合わせた肺高血圧の検出∼今後の展望と課題点について∼,
第86回日本循環器学会学術集会, 2022年3月. Kenya Kusunose, Hirotsugu Yamada and Masataka Sata :
Potential of AI-based Echocardiographic Analysis and Quantification in Clinical Practice,
第86回日本循環器学会学術集会, Mar. 2022. 平田由紀奈, 西尾進, 中尾隆之, 楠瀬賢也, 山田博胤, 佐田政隆 :
SGLT-2阻害薬が心機能へ与える効果と心外膜下脂肪厚軽減との関連,
第18回日本臨床検査医学合同地方会, 2022年2月. 北村彩乃, 大南博和, 増田真志, 奥村仙示, 伊勢孝之, 八木秀介, 福田大受, 山田博胤, 佐田政隆, 竹谷豊 :
運動および栄養介入が心不全マウスの病態に及ぼす影響,
日本心臓リハビリテーション学会第 5 回四国支部地方会, 2022年1月. 楠瀬賢也, 山田博胤, 佐田政隆 :
ポータブル心エコー機器の AI による進化,
POP超音波研究会, 2022年1月. 西條良仁, 佐村高明, 高橋智子, 大櫛祐一郎, 瀬野弘光, 高橋智紀, 門田宗之, 川端豊, 松浦朋美, 伊勢孝之, 楠瀬賢也, 山口浩司, 八木秀介, 山田博胤, 添木武, 若槻哲三, 秦広樹, 佐田政隆 :
滲出性収縮性心膜炎の1例,
第119回日本循環器学会四国地方会, 2021年12月. 數藤久美子, 福田大受, 伊勢孝之, 楠瀬賢也, 山口浩司, 八木秀介, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
マクロファージ特異的DNaseII欠損が動脈硬化に与える影響,
第119回日本循環器学会四国地方会, 2021年12月. 大櫛祐一郎, 楠瀬賢也, 西條良仁, 山口浩司, 八木秀介, 福田大受, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
心エコー検査によるがん治療関連心筋障害サーベイランスの有効性,
第119回日本循環器学会四国地方会, 2021年12月. 楠瀬賢也, 山田博胤, 佐田政隆 :
循環器領域の AI 開発∼ Radiomics in Echocardiography ∼,
日本超音波医学会第48回関西地方学術集会, 2021年10月. 楠瀬賢也, 山田博胤, 佐田政隆 :
人工知能(AI)による心エコー診断の進歩,
第69回日本心臓病学会学術集会, 2021年9月. Kenya Kusunose, Hirotsugu Yamada and Masataka Sata :
Implementation of artificial intelligence assessment in echocardiography ACC-JCC Joint Symposium Artificial Intelligence Approach for Cardiovascular Imaging Diagnostics,
第69回日本心臓病学会学術集会, Sep. 2021. 川端豊, 若槻哲三, 山口浩司, 門田宗之, 伊勢孝之, 楠瀬賢也, 松浦朋美, 八木秀介, 福田大受, 山田博胤, 添木武, 佐田政隆 :
冠動脈塞栓症を発症した2症例の臨床的検討,
第69回日本心臓病学会学術集会, 2021年9月. 楠瀬賢也, 大櫛祐一郎, 山田博胤, 佐田政隆 :
静脈血栓塞栓症における癌および経口抗凝固薬の予後に対する影響,
第69回日本心臓病学会学術集会, 2021年9月. 吉田知哉, 瀬野弘光, 松本和久, 松浦朋美, 西條良仁, 門田宗之, 川端豊, 楠瀬賢也, 伊勢孝之, 添木武, 山口浩司, 八木秀介, 山田博胤, 若槻哲三, 多田恵曜, 佐田政隆 :
ペースメーカー植え込み後に発覚した側頭葉てんかんによる発作性心静止の一例,
第263回徳島医学会学術集会, 2021年8月. Tserensonom Munkhtsetseg, 八木秀介, 伊勢孝之, 門田宗之, 川端豊, 西條良仁, 松浦朋美, 楠瀬賢也, 山口浩司, 福田大受, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
動脈硬化性疾患の高リスク患者において大動脈弁の石灰化と血清リポ蛋白との関連,
第263回徳島医学会学術集会, 2021年8月. 手束一貴, 高橋智紀, 西條良仁, 川端豊, 門田宗之, 松浦朋美, 伊勢孝之, 山口浩司, 八木秀介, 福田大受, 山田博胤, 添木武, 若槻哲三, 佐村高明, 秦広樹, 佐田政隆 :
ポスタ-セッション左冠動脈主幹部の急性冠症候群の2症例,
第263回徳島医学会学術集会(令和3年度夏期), 2021年8月. 伊勢孝之, 門田宗之, 川端豊, 楠瀬賢也, 山口浩司, 八木秀介, 福田大受, 山田博胤, 添木武, 若槻哲三, 佐村高明, 藤本鋭貴, 秦広樹, 佐田政隆 :
合同シンポジウムカテ-テル大動脈弁置換術(TAVI)によって激変した大動脈弁狭窄症治療,
第263回徳島医学会学術集会(令和3年度夏期), 2021年8月. 添木武, 福田大受, 松浦朋美, 飛梅威, 伊勢孝之, 楠瀬賢也, 山口浩司, 八木秀介, 山田博胤, 若槻哲三, 佐田政隆 :
Toll-Like Receptor 9 Is a Novel Therapeutic Target to Prevent Atrial Fibrillation,
JHRS2021 第67回日本不整脈心電学会学術大会, 2021年7月. 大南博和, 北村彩乃, 山口未来, 滝川真輝, 大西康太, 増田真志, 奥村仙示, 伊勢孝之, 八木秀介, 福田大受, 山田博胤, 佐田政隆, 竹谷豊 :
心不全マウスを用いた心リハ評価系の確立,
第27回日本心臓リハビテーション学会, 2021年6月. 松木勇樹, 芥川正武, 榎本崇宏, 北岡和義, 田中弘之, 山田博胤, 鳥居裕太, 木内陽介 :
収縮期加速時間と動脈硬化症の関連性に関する検討,
第60回日本生体医工学会大会, 2021年6月. 瀬野弘光, 山口浩司, 楠瀬賢也, 山田博胤, 若槻哲三, 添木武, 佐田政隆, 佐村高明, 秦広樹, 大豆本圭 :
広範な心嚢腔内進展を認めた心臓腫瘍の一例,
第116回第118回日本循環器学会中国・四国合同地方会, 2021年6月. 谷彰浩, 八木秀介, 門田宗之, 川端豊, 松浦朋美, 楠瀬賢也, 伊勢孝之, 飛梅威, 山口浩司, 福田大受, 山田博胤, 若槻哲三, 佐田政隆 :
肺動脈性肺高血圧症に対する静注プロスタグランジン投与で高心拍出を呈した症例,
第116回第118回日本循環器学会中国・四国合同地方会, 2021年6月. 大櫛祐一郎, 楠瀬賢也, 伊勢孝之, 山口浩司, 八木秀介, 福田大受, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
ループ利尿薬使用下における心保護薬併用療法の有用性,
第116回第118回日本循環器学会中国・四国合同地方会, 2021年6月. 西尾進, 山田博胤, 楠瀬賢也, 阿部美保, 林修司, 平田有紀奈, 山尾雅美, 添木武, 佐田政隆 :
徳島大学病院超音波センターの教育プログラム,
2021年5月. 楠瀬賢也, 荒瀬美晴, 平田有紀奈, 西尾進, 山尾雅美, 山田博胤, 阿部美保, 添木武, 佐田政隆 :
強皮症における6分間歩行負荷により評価した左室拡張能の臨床的意義,
第94回日本超音波医学会学術集会, 2021年5月. 瀬野弘光, 松本和久, 松浦朋美, 飛梅威, 添木武, 山口浩司, 八木秀介, 山田博胤, 若槻哲三, 佐田政隆 :
ペースメーカー植込み後にj発覚した側頭葉てんかんによる発作性心静止の1例,
第124回日本内科学会四国地方会, 2021年5月. PP Tran, Daiju Fukuda, Kumiko Suto, Shusuke Yagi, Kenya Kusunose, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
DNA Damage Caused by Diabetes Induced Vascular Dysfunction : The Role of The Stimulator of Interferon Genes,
第85回日本循環器学会学術集会, Mar. 2021. PP Tran, Daiju Fukuda, Kumiko Suto, Shusuke Yagi, Kenya Kusunose, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Stimulator of Interferon Genes Plays a Pivotal Role in Vascular Inflammation and Atherosclerosis in Apolipoprotein E-deficient Mice,
第85回日本循環器学会学術集会, Mar. 2021. Hirotsugu Yamada, Kenya Kusunose, Yoshihito Saijyo, Y Okushi, M Fujiwara and Masataka Sata :
Clinical Application of Strain Distribution by Speckle Tracking Echocardiography in Various Myocardial Disease,
第85回日本循環器学会学術集会, Mar. 2021. Koji Yamaguchi, Tetsuzo Wakatsuki, Yuichiroh Ohkushi, Kumiko Suto, 松本和久, Tomonori Takahashi, Muneyuki Kadota, Yutaka Kawabata, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Takeshi Tobiume, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Early and Chronic Phased Local Coagulative Responses Following Bioresorbable-polymer Drug-eluting Stent Implantation,
第85回日本循環器学会学術集会, Mar. 2021. Yutaka Kawabata, Tetsuzo Wakatsuki, Koji Yamaguchi, Daiju Fukuda, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Takeshi Tobiume, Shusuke Yagi, Hirotsugu Yamada, 添木武 and Masataka Sata :
Relationship between Coronary Intraplaque Microluminal Structure and Epicardial Adipose Tissue and Plaque Formation -A Fresh Cadaveric Study-,
第85回日本循環器学会学術集会, Mar. 2021. Yukina Hirata, Kenya Kusunose, 辻拓将, 藤森康平, YAMAGUCHI Natsumi, Sae Morita, Susumu Nishio, Yuichiroh Ohkushi, Hiromitsu Seno, 高橋智紀, Takayuki Ise, 飛梅威, Koji Yamaguchi, Daiju Fukuda, Shusuke Yagi, Hirotsugu Yamada, 添木武, Tetsuzo Wakatsuki, 古徳純一 and Masataka Sata :
Deep Learning for Detection of Elevated Pulmonary Artery Wedge Pressure Using Standard Chest X-Ray,
第85回日本循環器学会学術集会, Mar. 2021. Yuichiroh Ohkushi, Kenya Kusunose, 岡山佳弘, Hirotsugu Yamada and Masataka Sata :
Prognostic Impact of Cancer on Venous Thromboembolism from Japanese Registry of All Cardiac and Vascular Datasets,
第85回日本循環器学会学術集会, Mar. 2021. Kenya Kusunose, Hirotsugu Yamada and Masataka Sata :
Utilization of Artificial Intelligence for Echocardiography and X-ray in the Real World,
第85回日本循環器学会学術集会, Mar. 2021. Kenya Kusunose, Hirotsugu Yamada and Masataka Sata :
The Road to Automated Interpretation of Echocardiography with Artificial Intelligence,
第85回日本循環器学会学術集会, Mar. 2021. 阿部美保, Kenya Kusunose, Y Okushi, Zheng Robert, Takayuki Ise, Takeshi Tobiume, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Effects of Vitamin D Supplementation on Heart Failure Mortality from Japanese Registry of All Cardiac and Vascular Datasets,
第85回日本循環器学会学術集会, Mar. 2021. 川端豊, 若槻哲三, 山口浩司, 福田大受, 伊藤浩敬, 伊勢孝之, 楠瀬賢也, 松浦朋美, 飛梅威, 八木秀介, 山田博胤, 添木武, 佐田政隆 :
光干渉断層法で観察される冠動脈壁微小管腔構造と局所冠動脈周囲脂肪内炎症および冠動脈プラークの関連 -未固定遺体における検討-,
Beyond Angiography Japan XXV, 2021年3月. 山田拓哉, 谷彰浩, 門田宗之, 伊勢孝之, 川端豊, 松浦朋美, 楠瀬賢也, 飛梅威, 山口浩司, 八木秀介, 福田大受, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
大動脈四尖弁に対してTAVIを施行した一症例,
第262回徳島医師学会学術集会, 2021年3月. ムギー (名), 八木秀介, 門田宗之, 川端豊, 松本和久, 楠瀬賢也, 山口浩司, 飛梅威, 松浦朋美, 福田大受, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
当院におけるイバブラジンの使用経験,
第262回徳島医師学会学術集会, 2021年3月. 高橋寛典, 楠瀬賢也, 西尾進, 平田有紀奈, 山口夏美, 佐田政隆, 山田博胤, 高橋智紀, 瀬野弘光, 大櫛祐一郎 :
ESUSにおける新規発症心房細動と心エコー図指標との関連,
第85回日本循環器学会学術集会, 2021年3月. 平田有紀奈, 楠瀬賢也, 辻拓将, 藤森康平, 山口夏美, 森田沙瑛, 西尾進, 大櫛祐一郎, 瀬野弘光, 高橋智紀, 伊勢孝之, 飛梅威, 山口浩司, 福田大受, 八木秀介, 山田博胤, 添木武, 若槻哲三, 古徳純一, 佐田政隆 :
ディープラーニングによる胸部X-pを用いた肺動脈圧上昇の検出,
第85回日本循環器学会学術集会, 2021年3月. Muneyuki Kadota, Shusuke Yagi, Takayuki Ise, Yutaka Kawabata, Tomomi Matsuura, Kenya Kusunose, Takeshi Tobiume, Koji Yamaguchi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Acute Hormonal Effect of the Angiotensin Receptor-Neprilysin Inhibitor in Patients with Chronic Heart Failure,
第85回日本循環器学会学術集会, Mar. 2021. 楠瀬賢也, 山田博胤, 佐田政隆 :
AIが心エコー図法に与えるインパクト,
第31回日本心血管画像動態学会, 2021年1月. 西尾進, 森根裕二, 湯浅麻美, 松本力三, 平田有紀奈, 山尾雅美, 楠瀬賢也, 山田博胤, 島田光生, 佐田政隆 :
下大静脈原発平滑筋肉腫の1例,
日本超音波医学会第93回学術集会, 2020年12月. 楠瀬賢也, 芳賀昭弘, 山田博胤, 西尾進, 平田有紀奈, 佐田政隆 :
加速する循環器画像領域におけるAI研究の現在と未来,
日本超音波医学会第93回学術集会, 2020年12月. 瀬野弘光, 楠瀬賢也, 谷彰浩, 大櫛祐一郎, 高橋智紀, 山田博胤, 平田有紀奈, 山尾雅美, 西尾進, 佐田政隆 :
肥大型心筋症に心房性僧帽弁閉鎖不全症を合併し，重症心不全を呈した一例,
日本超音波医学会第30回四国地方会学術集会, 2020年10月. 高橋智紀, 楠瀬賢也, 山口夏美, 平田有紀奈, 西尾進, 大櫛祐一郎, 瀬野弘光, 林修司, 山田博胤, 佐田政隆 :
経食道心臓超音波検査における左心耳内血栓評価にイソプロテレノール負荷が有用であった1例,
日本超音波医学会第30回四国地方会学術集会, 2020年10月. 山田博胤, 大櫛祐一郎, 楠瀬賢也, 佐田政隆 :
心エコー図検査を用いたCTRCD診断のピットフォール,
第3回日本腫瘍循環器学会学術集会, 2020年9月. 大櫛祐一郎, 楠瀬賢也, 山口夏美, 森田沙瑛, 平田有紀奈, 山尾雅美, 西尾進, 高橋智紀, 山田博胤, 佐田政隆 :
乳がん症例における化学療法開始後のトロポニンⅠ上昇の臨床的意義,
第3回日本腫瘍循環器学会学術集会, 2020年9月. Kenya Kusunose, Hirotsugu Yamada, 中谷敏 and Masataka Sata :
Prospects for the Present and Future of Artificial Intelligence in Echocardiography,
第84回日本循環器学会学術集会, Aug. 2020. Koji Yamaguchi, Tetsuzo Wakatsuki, Yuichiroh Ohkushi, Kumiko Sutou, Kazuhisa Matsumoto, Tomonori Takahashi, Muneyuki Kadota, 上野理絵, Yutaka Kawabata, Tomomi Matsura, Takayuki Ise, Kenya Kusunose, Takeshi Tobiume, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
The Effect of Lower Strut Thickness and Faster Polymer Resorption on Chronic Local Coagulative Response after Drug Eluting Stent Implantation,
第84回日本循環器学会学術集会, Jul. 2020. Gulinu Maimaituxun, Kenya Kusunose, Daiju Fukuda, Shusuke Yagi, Hirata Yukina, Hirotsugu Yamada, Takeshi Soeki, Masataka Sata and Michio Shimabukuro :
Impact of Epicardial Adipose Tissue on Global Longitudinal Strain in Patients with Normal Left Ventricular Ejection Fraction,
第84回日本循環器学会学術集会, Jul. 2020. Ganbaatar Byambasuren, Daiju Fukuda, Shusuke Yagi, Kenya Kusunose, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
S1P2 Receptor Antagonist Attenuates Endothelial Dysfunction and Prevents Atherogenesis in Apolipoprotein-E-deficient Mice,
第84回日本循環器学会学術集会, Jul. 2020. Suto Kumiko, Daiju Fukuda, Shusuke Yagi, Kenya Kusunose, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Pemafibrate, a Novel Selective Peroxisome Proliferator-activated Receptor-α Modulator, Attenuates Vascular Inflammation and Endothelial Dysfunction in Diabetic Mice,
第84回日本循環器学会学術集会, Jul. 2020. 楠瀬賢也, 芳賀昭弘, 門田宗之, 石井亜由美, 伊勢孝之, 八木秀介, 山田博胤, 佐田政隆 :
心エコーへのAI応用について,
第26回日本心臓リハビリテーション学会学術集会, 2020年7月. 田中敦史, 田口功, 寺川宏樹, 石坂信和, 神崎裕美子, 冨山博史, 佐田政隆, 瀬在明, 江口和男, 加藤徹, 豊田茂, 石橋亮一, 石津智子, 植田真一郎, 前村浩二, 東幸仁, 山田博胤, 大石充, 室原豊明, 尾山純一, 野出孝一 :
無症候性高尿酸血症におけるフェブキソスタットの頸動脈内膜中膜複合体,
第52回日本動脈硬化学会総会学術集会, 2020年7月. 田中敦史, 田口功, 寺川宏樹, 石坂信和, 神崎裕美子, 冨山博史, 佐田政隆, 瀬在明, 江口和男, 加藤徹, 豊田茂, 石橋亮一, 苅尾七臣, 石津智子, 植田真一郎, 前村浩二, 東幸仁, 山田博胤, 大石充, 横手幸太郎, 室原豊明, 尾山純一, 野出孝一 :
無症候性高尿酸血症におけるフェブキソスタットの頸動脈内膜中膜複合体厚に対する効果の検,
第52回日本動脈硬化学会総会学術集会, 2020年7月. 芥川正武, 寺井優輝, 榎本崇宏, 北岡和義, 田中弘之, 山田博胤, 鳥居裕太, 木内陽介 :
動脈硬化症患者の頸動脈血流速度波形に関する検討,
第59回日本生体医工学会学術大会, 2020年5月. 山田博胤, 宮坂陽子, 高麗雅明 :
脳卒中患者におけるOD錠の製剤メリット，心房細動と心不全∼最良の治療を目指して∼,
日本人の抗血栓療法WEBセミナー, 2019年12月. 楠瀬賢也, 山田博胤, 西尾進, 平田有紀奈, 鳥居裕太, 大櫛祐一郎, 高橋智紀, 山田なお, 佐田政隆 :
Isolated Post-capillaryとCombined Pre- and Post-capillary PHの予後予測指標の検討,
関西心エコーリサーチクラブ, 2019年12月. 松本和久, 川端豊, 松浦朋美, 飛梅威, 添木武, 山田博胤 :
リードレスペースメーカーの再挿入を要したアミロイドーシスの一例,
第115回日本循環器学会四国地方会, 2019年12月. 門田宗之, 楠瀬賢也, 伊勢孝之, 髙橋智紀, 藤本裕太, 大櫛祐一郎, 數藤久美子, 松本和久, 上野理絵, 川端豊, 山田なお, 松浦朋美, 飛梅威, 山口浩司, 八木秀介, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
ドブダミン負荷下での血行動態評価を行った潜在性閉塞性肥大型心筋症2症例の検討,
第115回日本循環器学会四国地方会, 2019年12月. 山口浩司, 若槻哲三, 松本和久, 髙橋智紀, 上野理絵, 川端豊, 松浦朋美, 楠瀬賢也, 飛梅威, 伊勢孝之, 八木秀介, 山田博胤, 添木武, 佐田政隆 :
クライオバルーンアブレーション後の肺静脈狭窄に対するDrug coated balloonの使用経験,
第115回日本循環器学会四国地方会, 2019年12月. 山口浩司, 若槻哲三, 松本和久, 髙橋智紀, 上野理絵, 川端豊, 松浦朋美, 楠瀬賢也, 伊勢孝之, 飛梅威, 八木秀介, 山田博胤, 添木武, 佐田政隆 :
新規病変に対するDrug coated balloonの効果―局所血管反応と臨床成績について―,
第115回日本循環器学会四国地方会, 2019年12月. 山田博胤, 和田靖明 :
心房細動の心エコーと抗凝固療法,
心房細動と心エコー図の勉強会, 2019年12月. 山田博胤, 原田顕治 :
抗凝固療法のためのちょいあて心エコー法∼Basic Focused Cardiac Ultrasound(FoCUS)∼,
水戸心臓脈管カンファレンス, 2019年11月. 山田博胤, 篠田旬子 :
抗血栓療法のための心・血管エコー活用法∼心房細動と静脈血栓症∼,
心・血管エコーと心房細動を勉強する会, 2019年11月. 山田博胤 :
心エコー図で考える心房細動と心不全の深∼い繋がり,
循環器疾患連携講演会, 2019年11月. 山田博胤 :
心エコー図で考える心房細動と心不全の深∼い繋がり,
循環器疾患連携講演会,特別講演, 2019年11月. 山田博胤 :
腫瘍循環器診療はエコーで片付く -がん関連血栓塞栓症を含めて-,
薬師寺心血管エコーセミナー, 2019年11月. 山田博胤 :
腫瘍循環器診療はエコーで片付く,
薬師寺心エコーセミナー,特別講演, 2019年11月. 山田博胤 :
VTEの診断と治療心血管エコー検査ビデオライブ,
イグザレルトWEB件カンファレンス, 2019年11月. 山田博胤 :
Cancer Associated Thrombosis スクリーニング∼徳島大学超音波センターとがん診療医の連携∼,
Thrombosis Expert Meeting for VTE, 2019年11月. 山田博胤 :
静脈血栓症における心・血管エコー検査の役割,
第2回CATセミナー in Tokorozawa, 2019年10月. 山田博胤 :
"Onco-cardiologyにおける超音波検査の役割∼Cancer VTEとCTRCDの診断∼,
日本超音波医学会第46回関西地方会ランチョンセミナー, 2019年10月. 山田博胤 :
心エコー図による心不全の5step診断法,
心不全診療WEBセミナー, 2019年10月. 山田博胤 :
Onco-cardiology における超音波検査の役割 ∼ Cancer VTE とCTRCD の診断∼,
日本超音波医学会第29回四国地方会学術集会ランチョンセミナー, 2019年10月. 松本力三, 西尾進, 湯浅麻美, 森田沙瑛, 平田有紀奈, 鳥居裕太, 山尾雅美, 楠瀬賢也, 山田博胤, 佐田政隆 :
医原性仮性動脈瘤による正中神経麻痺の診断に超音波検査が有用であった1 例,
日本超音波医学会第29回四国地方会学術集会, 2019年10月. 平田有紀奈, 西尾進, 楠瀬賢也, 工藤隆治, 高橋章, 松本真依, 湯浅麻美, 楠瀬賢也, 山田博胤, 佐田政隆 :
含水法で明瞭に描出できた口腔内癌の1 例,
日本超音波医学会第29回四国地方会学術集会, 2019年10月. 山口夏美, 西尾進, 楠瀬賢也, 平田有紀奈, 鳥居裕太, 山尾雅美, 山尾雅美, 大櫛祐一郎, 山田なお, 山田博胤, 佐田政隆 :
当院における心室中部型たこつぼ心筋症の発症頻度と臨床的特徴,
日本超音波医学会第29回四国地方会学術集会, 2019年10月. 大櫛祐一郎, 楠瀬賢也, 松本力三, 平田有紀奈, 鳥居裕太, 山尾雅美, 西尾進, 山田なお, 山田博胤, 佐田政隆 :
経胸壁心エコー上で結節様に観察されたThebesian 弁の一例,
日本超音波医学会第29回四国地方会学術集会, 2019年10月. 山田博胤 :
胸痛のPOCUS,
臨床Point-of-Care超音波セミナー, 2019年10月. 山田博胤, 和田靖明 :
心不全×心エコー×笑,
2019年度日本臨牀衛生検査技師会第8回北日本支部医学検査学会教育講演, 2019年10月. 鳥居裕太, 山田博胤 :
腫瘍循環器診療における技師による外来簡易超音波検査の試み,
第23回日本心不全学会学術集会, 2019年10月. 鳥居裕太, 楠瀬賢也, 山田博胤, 山口夏美, 森田沙瑛, 平田有紀奈, 西尾進, 大櫛祐一郎, 髙橋智紀, 山田なお, 佐田政隆 :
心不全入院患者における左室拡張能評価と心血管イベントの関連:2009 年・2016 年拡張能ガイドラインの比較,
第23回日本心不全学会学術集会, 2019年10月. 山田博胤 :
心房細動治療における心エコー図の役割,
地域連携WEbセミナーin高松, 2019年10月. 山田博胤 :
Onco-cardiologyに対する当院の取り組み,
地域医療構想2015について徳島のあり方を考える会∼循環器病克服5か年計画を見据えて∼, 2019年9月. 山田博胤 :
がん患者の心エコー図は何をみるべきか,
第12回瀬戸内エコーセミナー, 2019年9月. 山田博胤 :
心不全診断のための心エコー図,
第12回瀬戸内エコーセミナー, 2019年9月. 山田博胤, 和田靖明 :
Onco-cardiologyにおける心血管エコー検査の役割,
第12回瀬戸内エコーセミナーランチョンセミナー, 2019年9月. Pham Tran Phuong, Daiju Fukuda, Shusuke Yagi, Kenya Kusunose, Hirotsugu Yamada, Takeshi Soeki, Michio Shimabukuro and Masataka Sata :
Rivaroxaban,a direct inhibitor of FXa,attenuated diabetes-induced endothelial dysfunction in wild-type mice,
日本性機能学会第30回学術集会, Sep. 2019. Arief Rahadian, Daiju Fukuda, Hotima Salim, Shusuke Yagi, Kenya Kusunose, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
SGLT2 inhibitor,Canagliflozin,Ameliorate Endothelial Dysfunction and Atherosclerosis in Diabetic ApoE-/- Mice,
日本性機能学会第30回学術集会, Sep. 2019. Aini Kunduziayi, Daiju Fukuda, Shusuke Yagi, Kenya Kusunose, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Vildagliptin,a DPP-4 Inhibitor,prevents endothelial dysfunction in nondiabetic apolipoprotein E-deficient mice,
日本性機能学会第30回学術集会, Sep. 2019. 梶川正人, 丸橋達也, 日高貴之, 中野由紀子, 栗栖智, 大原康樹, 廣高史, 平山篤志, 椎名一紀, 冨山博史, 八木秀介, 天野里江, 山田博胤, 佐田政隆 :
2型糖尿病患者におけるサキサグリプチンの血管内皮機能に及ぼす効果,
第67回日本心臓病学会学術集会, 2019年9月. 山口浩司, 若槻哲三, 川端豊, 山田なお, 楠瀬賢也, 伊勢孝之, 八木秀介, 山田博胤, 添木武, 佐田政隆 :
Optical coherence omographyにより器質化血栓の存在が疑われた肺癌術後急性冠症候群の1例,
第67回日本心臓病学会学術集会, 2019年9月. 楠瀬賢也, 芳賀昭弘, 山田博胤, 中谷敏, 佐田政隆 :
心エコー図法における人工知能技術活用の今(シンポジウム19 AIでどこまで心臓病診療は進むか?),
第67回日本心臓病学会学術集会, 2019年9月. 楠瀬賢也, 山田博胤, 佐田政隆 :
運動誘発性肺高血圧の臨床的意義と未来(シンポジウム14 負荷心エコーの展望),
第67回日本心臓病学会学術集会, 2019年9月. 山口夏美, 楠瀬賢也, 芳賀昭弘, 森田沙瑛, 平田有紀奈, 鳥居裕太, 西尾進, 山田なお, 阿部美保, 福田大受, 山田博胤, 佐田政隆 :
深層学習を用いた左室駆出率の推定:心エコー図法による検討(優秀演題メディカルスタッフ),
第67回日本心臓病学会学術集会, 2019年9月. 平田有紀奈, 楠瀬賢也, 山口夏美, 森田沙瑛, 鳥居裕太, 西尾進, 山田なお, 阿部美保, 山田博胤, 佐田政隆 :
心外膜下脂肪厚と性差および年齢との関連(優秀演題メディカルスタッフ),
第67回日本心臓病学会学術集会, 2019年9月. 山田なお, 小島友子, 山田博胤, 楠瀬賢也, 西尾進, 林修司, 藤原美佳, 西條良仁, 平田有紀奈, 鳥居裕太, 佐田政隆 :
高血圧心疾患における左室拡張期電気機械的カップリングの非侵襲的評価,
第67回日本心臓病学会学術集会, 2019年9月. 楠瀬賢也, 山田博胤, 松久宗英 :
診断に活かす局所心筋ストレイン解析(会長特別企画【原点を学び未来を創る】8 日常臨床に活かす心筋ストレイン解析),
第67回日本心臓病学会学術集会, 2019年9月. 山田博胤, 松原進 :
下肢静脈エコーライブデモンストレーション，Onco-cardiology腫瘍循環器学の夜明け:がん治療と血栓症,
三原内科会, 2019年9月. 木田貴弘, 飛梅威, 松本和久, 坂東左知子, 松浦朋美, 添木武, 志村拓哉, 髙橋智子, 谷彰浩, 藤本裕太, 大櫛祐一郎, 數藤久美子, 髙橋智紀, 上野理絵, 門田宗之, 川端豊, 坂東美佳, 山田なお, 伊藤浩敬, 伊勢孝之, 楠瀬賢也, 山口浩司, 八木秀介, 福田大受, 山田博胤, 若槻哲三, 佐田政隆 :
房室ブロックの進行に伴い明らかになり，恒久的ペースメーカー植込み術後のファーフィールドR波センシングへの関与が疑われた束枝心室間副伝導路の1例,
第259回徳島医学会学術集会, 2019年8月. 井口裕貴, 飛梅威, 松本和久, 坂東左知子, 松浦朋美, 添木武, 志村拓哉, 髙橋智子, 谷彰浩, 藤本裕太, 大櫛祐一郎, 數藤久美子, 髙橋智紀, 上野理絵, 門田宗之, 川端豊, 坂東美佳, 山田なお, 伊藤浩敬, 伊勢孝之, 楠瀬賢也, 山口浩司, 八木秀介, 福田大受, 山田博胤, 若槻哲三, 佐田政隆 :
房室ブロックの予防に順行性速伝導路と順行性遅伝導路のマッピングが有用であった順行性速伝導路の下方偏位を伴う遅速型房室結節リエントリー性頻拍の1例,
第259回徳島医学会学術集会, 2019年8月. 山田博胤 :
Onco-cardiologyにおける心血管エコー検査の活用∼Cancer VTE時代を踏まえて∼,
Sakurayama Thrombosis Academy, 2019年7月. 山田博胤, 泉佑樹 :
心エコー講義&ライブスキャニング,
第7回Point-og-Care超音波研究会 1-dayセミナー, 2019年7月. 山田博胤 :
抗血栓療法のための心・血管エコー活用法∼心エコーを専門としていないかたのためのPoint-of-Care心血管エコーライブレクチャー∼,
改めて心臓超音波エコーと抗凝固療法を勉強する会, 2019年7月. 山田博胤 :
日常診療に潜む肺高血圧,
鳴門市医師会学術講演会, 2019年7月. 山田博胤 :
静脈血栓症の超音波診断とエドキサバンの最新情報∼徳島大学病院超音波センターの取り組み∼,
第39回日本静脈学会ランチョンセミナー, 2019年7月. 山田博胤 :
Onco-cardiologyにおける心血管エコー検査の役割,
第3回VTE診断と治療を考える会, 2019年6月. Gulinu Maimaituxun, Daiju Fukuda, Shusuke Yagi, Yukina Hirata, Takashi Iwase, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Koji Yamaguchi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Masataka Sata and Michio Shimabukuro :
Gender specific impact of epicardial adipose tissue thickness on coronary artery disease,
第19回日本抗加齢医学会総会, Jun. 2019. 山田博胤, 和田靖明 :
深部静脈血栓症の診断と治療∼レクチャー&ライブデモンストレーション,
山口大学病院エコーカンファレンス, 2019年6月. 山田博胤 :
No Echo, No Life!∼心疾患の治療とエコー活用術∼,
第21回下関循環器研究会, 2019年6月. 森田沙瑛, 西尾進, 楠瀬賢也, 添木武, 松本和久, 山口夏美, 平田有紀奈, 鳥居裕太, 西條良仁, 山田博胤, 佐田政隆 :
右室容量負荷の原因を経胸壁心エコー図検査で診断し得なかった1例,
第114回日本循環器学会中国・四国合同地方会, 2019年6月. 數藤久美子, 楠瀬賢也, 松浦朋美, 山田なお, 松本和久, 上野理絵, 川端豊, 伊勢孝之, 飛梅威, 山口浩司, 八木秀介, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
進行性心不全を呈す抗ミトコンドリア抗体陽性筋炎の症例,
第114回日本循環器学会中国・四国合同地方会, 2019年6月. 山田なお, 山田博胤, 楠瀬賢也, 大櫛祐一郎, 髙橋智紀, 林修司, 阿部美保, 坂東美佳, 西條良仁, 鳥居裕太, 平田有紀奈, 西尾進, 佐田政隆 :
肥大型心筋症に心房機能性僧帽弁閉鎖不全症を合併し，重症心不全を呈した一例,
第114回日本循環器学会中国・四国合同地方会, 2019年6月. 谷彰浩, 楠瀬賢也, 松本和久, 松浦朋美, 伊勢孝之, 飛梅威, 山口浩司, 八木秀介, 福田大受, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
拡張期僧帽弁逆流の治療適応判断に心房心室同時ペーシングが有効であった1例,
第114回日本循環器学会中国・四国合同地方会, 2019年6月. 志村拓哉, 伊勢孝之, 川端豊, 藤本裕太, 松本和久, 上野理絵, 山田なお, 伊藤浩敬, 松浦朋美, 楠瀬賢也, 山口浩司, 八木秀介, 福田大受, 山田博胤, 添木武, 若槻哲三, 黒部裕嗣, 藤本鋭貴, 佐田政隆 :
先天性二尖弁に対するTAVIの2例,
第114回日本循環器学会中国・四国合同地方会, 2019年6月. 大池由夏, 飛梅威, 松本和久, 山田なお, 坂東左知子, 松浦朋美, 伊勢孝之, 楠瀬賢也, 山口浩司, 若槻哲三, 添木武, 山田博胤, 佐田政隆 :
His束より上方レベルの心房刺激でのみ誘発可能であった房室結節リエントリー性頻拍の1例,
第114回日本循環器学会中国・四国合同地方会, 2019年6月. 中村昌史, 川端豊, 伊勢孝之, 藤本裕太, 原田貴文, 松本和久, 西條良仁, 上野理絵, 山田なお, 伊藤浩敬, 轟貴史, 楠瀬賢也, 飛梅威, 山口浩司, 福田大受, 八木秀介, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
経食道心エコーガイド下の経皮的腫瘍生検により早期に診断し得た心臓原発血管肉腫の一例,
第114回日本循環器学会中国・四国合同地方会, 2019年6月. 松本力三, 鳥居裕太, 若槻哲三, 西尾進, 湯浅麻美, 平田有紀奈, 山尾雅美, 楠瀬賢也, 山田博胤, 佐田政隆 :
右大腿動静脈瘻修復術後に繰り返し生じた深部静脈血栓症の1例,
第114回日本循環器学会中国・四国合同地方会, 2019年6月. 山尾雅美, 西尾進, 山口夏美, 平田有紀奈, 松本和久, 西條良仁, 阿部美保, 楠瀬賢也, 山田博胤, 佐田政隆 :
脳梗塞の原因精査の心エコー図検査で右室内異常構造物を認めた卵巣癌の1例,
第114回日本循環器学会中国・四国合同地方会, 2019年6月. 平田有紀奈, 楠瀬賢也, 賀川久美子, 山口夏美, 森田沙瑛, 鳥居裕太, 山尾雅美, 西尾進, 山田なお, 松浦朋美, 阿部美保, 山田博胤, 佐田政隆 :
悪性リンパ腫の診断および経過観察に心エコー図検査が有用であった1例,
第114回日本循環器学会中国・四国合同地方会, 2019年6月. 鳥居裕太, 山田博胤, 楠瀬賢也, 山田なお, 大櫛祐一郎, 西尾進, 平田有紀奈, 森田沙瑛, 山口夏美, 佐田政隆 :
左室拡張機能評価を用いた心房細動合併心不全の予後予測:新旧ガイドライン(2009年，2016年)の比較,
第114回日本循環器学会中国・四国合同地方会, 2019年6月. 西尾進, 楠瀬賢也, 平田有紀奈, 西條良仁, 山田なお, 鳥居裕太, 山尾雅美, 添木武, 山田博胤, 佐田政隆 :
右心機能評価,
日本超音波医学会第92回学術集会パネルディスカッション循環器2, 2019年5月. 山田博胤, 楠瀬賢也, 西條良仁, 山田なお, 鳥居裕太, 平田有紀奈, 山尾雅美, 西尾進, 添木武, 佐田政隆 :
ASE/EACVI の心腔計測ガイドライン2015 の概要,
日本超音波医学会第92回学術集会パネルディスカッション循環器1, 2019年5月. 山田博胤, 西條良仁, 楠瀬賢也, 山田なお, 鳥居裕太, 平田有紀奈, 山尾雅美, 西尾進, 添木武, 佐田政隆 :
「がん治療関連心筋障害(CTRCD)」の診療における心エコー図検査の有用性,
日本超音波医学会第92回学術集会シンポジウム循環器7, 2019年5月. Gulinu Maimaituxun, Daiju Fukuda, Shusuke Yagi, Tsukasa Iwase, Kenya Kusunose, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Masataka Sata and Michio Shimabukuro :
Type 2 diabetes but not apicardial adipose tissue thickness is a predictor for coronary artery diseases in women,
第62回日本糖尿病学会年次学術集会, May 2019. 阿部美保, 楠瀬賢也, 山田博胤, 山田なお, Robert Zheng, 西條良仁, 西尾進, 平田有紀奈, 鳥居裕太, 佐田政隆 :
血清IgG4 値と心エコー図検査指標との関連性,
日本超音波医学会第92回学術集会, 2019年5月. 西尾進, 楠瀬賢也, 高橋寛典, 鹿草宏, 平田有紀奈, 森田沙瑛, 山口夏美, 鳥居裕太, 山尾雅美, Zheng Robert, 西條良仁, 山田なお, 林修司, 阿部美保, 武市脩, 山田博胤, 佐田政隆 :
急性脳梗塞患者の病型分類におけるB型ナトリウム利尿ペプチドと心エコー図指標の臨床的意義,
日本心エコー図学会第30回学術集会, 2019年5月. 山田博胤 :
腫瘍循環器診療における超音波検査の役割:腫瘍循環器外来と超音波センターの連携,
日本心エコー図学会第30回学術集会, 2019年5月. 平田有紀奈, 楠瀬賢也, 西尾進, 原田修, 宮里尚美, 原國督, 森田沙瑛, 西尾進, 鳥居裕太, 山尾雅美, 山田博胤, 佐田政隆 :
超音波検査を用いた心外膜下脂肪厚の測定精度の検討,
日本心エコー図学会第30回学術集会, 2019年5月. 森田沙瑛, 楠瀬賢也, 平田有紀奈, 鳥居裕太, 天野理江, 西條良仁, 山田なお, 西尾進, 山尾雅美, 阿部美保, 伊勢孝之, 山田博胤, 佐田政隆 :
全身性強皮症における運動誘発性肺高血圧症の高リスク群の同定,
日本心エコー図学会第30回学術集会, 2019年5月. 楠瀬賢也, 山田博胤, 西尾進, 佐田政隆 :
疣腫を視るー感染性心内膜炎のエコー診断,
日本心エコー図学会第30回学術集会, 2019年5月. 楠瀬賢也, 山田博胤, 西尾進, 佐田政隆 :
心房細動と左房機能解析,
日本心エコー図学会第30回学術集会, 2019年5月. Gulinu Maimaituxun, Kenya Kusunose, Hirotsugu Yamada, Daiju Fukuda, Shusuke Yagi, Yukina Hirata, T Iwase, Takeshi Soeki, Masataka Sata and Michio Shimabukuro :
Impact of epicardial adipose tissue thickness on left ventricular diastolic dysfunction in human,
第92回日本内分泌学会学術総会, May 2019. Gulinu Maimaituxun, Daiju Fukuda, Shusuke Yagi, Yukina Hirata, T Iwase, S Takao, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Takeshi Tobiume, Koji Yamaguchi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Masafumi Harada, Masataka Sata and Michio Shimabukuro :
Kidney fat and its impact on coronary artery disease,
第4回日本血管不全学会学術集会・総会, Apr. 2019. Gulinu Maimaituxun, Daiju Fukuda, Shusuke Yagi, Yukina Hirata, T Iwase, S Takao, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Takeshi Tobiume, Koji Yamaguchi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Masafumi Harada, Masataka Sata and Michio Shimabukuro :
Peri-renal fat volume is negatively associated with the adiponectin expression in human,
第4回日本血管不全学会学術集会・総会, Apr. 2019. 平田有紀奈, 西尾進, 山口夏美, 森田沙瑛, 鳥居裕太, 山尾雅美, 楠瀬賢也, 山田博胤, 佐田政隆 :
心外膜下脂肪厚とBody mass indexとの関連,
超音波検査技術, Vol.44, No.Suppl, S165, 2019年4月. Pham Tran Phuong, 福田大受, 八木秀介, 楠瀬賢也, 山田博胤, 添木武, 島袋充生, 佐田政隆 :
Rivaroxaban, A Direct Inhibitor of FXa, Attenuated Diabetes-induced Endothelial Dysfunction by Inhibiting FXa-protease Activated Receptor 2 Signaling,
第83回日本循環器学会学術集会, 2019年3月. 伊藤浩敬, 若槻哲三, 山口浩司, 福田大受, 川端豊, 轟貴史, 松浦朋美, 伊勢孝之, 楠瀬賢也, 飛梅威, 八木秀介, 山田博胤, 添木武, 佐田政隆 :
Microluminal structures of coronary plaque and vasa vasorums affect coronary inflammation: A fresh cadaveric studys,
第83回日本循環器学会学術集会, 2019年3月. 添木武, 松浦朋美, 福田大受, 松本和久, 飛梅威, 楠瀬賢也, 山田博胤, 若槻哲三, 佐田政隆 :
The Factor Xa Inhibitor, Edoxaban, Prevents Cardiac Remodeling in Rats with Myocardial Infarction,
第83回日本循環器学会学術集会, 2019年3月. 楠瀬賢也, 山田博胤, 佐田政隆 :
Stress Echocardiography for Pulmonary Hypertension,
第83回日本循環器学会学術集会, 2019年3月. 川端豊, 若槻哲三, 山口浩司, 伊藤浩敬, 福田大受, 轟貴史, 松浦朋美, 伊勢孝之, 楠瀬賢也, 飛梅威, 八木秀介, 山田博胤, 添木武, 佐田政隆 :
Coronary intraplaque microluminal structure are associated with the quality and quantity of epicardial adipose tissue -A fresh cadaveric stury-,
第83回日本循環器学会学術集会, 2019年3月. 平田有紀奈, 楠瀬賢也, 山田博胤, 森田沙瑛, 鳥居裕太, 西尾進, ゼングロバート, 西條良仁, 八木秀介, 添木武, 佐田政隆 :
マラソン完走後の左房リザーバーストレイン反応を予測する指標の検討,
第83回日本循環器学会学術集会, 2019年3月. Arief Rahadian, Daiju Fukuda, Shusuke Yagi, Kenya Kusunose, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Canagliflozin, a Sglt-2 Inhibitor, Prevents Endothelial Dysfunction and Atherosclerosis in Diabetic Apolipoprotein E-deficient Mice,
第83回日本循環器学会学術集会, Mar. 2019. Byambasuren Ganbaatar, Daiju Fukuda, Shusuke Yagi, Kenya Kusunose, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Empagliflozin Attenuates Endothelial Dysfunction and Atherogenesis by Inhibiting Inflammation in the Vasculature and Adipose Tissue in Diabetic Apolipoprotein E-deficient Mice,
第83回日本循環器学会学術集会, Mar. 2019. Aini Kunduziayi, Daiju Fukuda, Shusuke Yagi, Kenya Kusunose, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Vildagliptin, a DPP-4 Inhibitor, Prevents Atherogenesis Targeting Multiple Cell-types in Non-diabetic Apolipoprotein E-deficient Mice,
第83回日本循環器学会学術集会, Mar. 2019. 楠瀬賢也, 鳥居裕太, 山田博胤, 佐田政隆 :
Clinical Role of Cardiovascular Imaging for IgG4-related Cardiovascular Disease,
第83回日本循環器学会学術集会, 2019年3月. 森田沙瑛, 楠瀬賢也, 山田博胤, 西尾進, 平田有紀奈, 鳥居裕太, 西條良仁, 阿部美保, 佐田政隆 :
強皮症における6分間歩行距離の規定因子:新エコー図法を用いた検討,
第83回日本循環器学会学術集会, 2019年3月. 平田有紀奈, 楠瀬賢也, 山田博胤, 森田沙瑛, 鳥居裕太, 西尾進, 山口夏美, Robert Zheng, 西條良仁, 八木秀介, 添木武, 佐田政隆 :
カーフスリーブは下腿浮腫を軽減するか:表在エコー検査による検討,
第83回日本循環器学会学術集会, 2019年3月. 藤本裕太, 楠瀬賢也, 西條良仁, Robert Zheng, 原田貴文, 松本和久, 上野理絵, 川端豊, 山田なお, 伊藤浩敬, 轟貴史, 伊勢孝之, 飛梅威, 山口浩司, 八木秀介, 添木武, 山田博胤, 添木武, 若槻哲三, 黒部裕嗣, 佐田政隆 :
Staphylococcus による感染性内膜炎の一例,
第113回日本循環器学会四国合同地方会, 2018年12月. Robert Zheng, 伊勢孝之, 川端豊, 八木秀介, 西條良仁, 上野理絵, 坂東美佳, 伊藤浩敬, 轟貴史, 松浦朋美, 楠瀬賢也, 飛梅威, 山口浩司, 福田大受, 山田博胤, 添木武, 若槻哲三, 黒部裕嗣, 藤本鋭貴, 北川哲也, 佐田政隆 :
Single coronary 合併重症ASに対してTAVIを施行し救命し得た1例,
第113回日本循環器学会四国合同地方会, 2018年12月. 西條良仁, 山田博胤, 楠瀬賢也, 佐田政隆 :
アントラサイクリン系抗がん剤による左室心筋障害の局在性とがん治療関連心機能障害発生の検討,
第1回日本腫瘍循環器学会学術集会, 2018年11月. 楠瀬賢也, 山田博胤, 西條良仁, 佐田政隆 :
Vascular endothelial growth factor 阻害薬の眼内投与後に急性冠症候群を発症した 4 症例,
第1回日本腫瘍循環器学会学術集会, 2018年11月. 山田博胤, 坂東美佳, 楠瀬賢也, 西條良仁, 佐田政隆 :
腫瘍循環器診療における超音波検査の役割，腫瘍循環器外来と超音波センターの連携,
第1回日本腫瘍循環器学会学術集会, 2018年11月. 山田博胤, 平田有紀奈, 坂東美佳, 楠瀬賢也, 西條良仁, 西尾進, 添木武, 佐田政隆 :
心外膜下脂肪厚の超音波計測とその臨床的意義,
第45回日本超音波医学会関西地方会, 2018年10月. Kenya Kusunose, Yuta Torii, Takayuki Ise, Hirotsugu Yamada and Masataka Sata :
Incremental Prognostic Value of Diastolic Dysfunction by updated recommendation,
第22回日本心不全学会学術集会(東京), Oct. 2018. 工藤明宏, 待井典剛, 小野利夫, 大城義人, 高橋隆, 種田嘉信, 比嘉盛丈, 八木秀介, 仲地健, 小林淳, 及川雅啓, 山田博胤, 竹石恭知, 佐田政隆, 島袋充生 :
時効型インスリン療法中の2型糖尿病患者におけるタバグリフロジンの血糖日内変動に及ぼす効果,
第39回日本肥満学会(神戸), 2018年10月. 川端豊, 若槻哲三, 山口浩司, 伊藤浩敬, 楠瀬賢也, 松浦朋美, 轟貴史, 飛梅威, 八木秀介, 山田博胤, 添木武, 佐田政隆 :
未固定遺体において光干渉断層法で観察される冠動脈壁微小管腔構造と局所周囲脂肪炎症との関連,
第66回日本心臓病学会学術集会, 2018年9月. 伊藤浩敬, 若槻哲三, 山口浩司, 福田大受, 川端豊, 伊勢孝之, 楠瀬賢也, 松浦朋美, 轟貴史, 飛梅威, 八木秀介, 山田博胤, 添木武, 佐田政隆 :
未固定遺体における冠動脈壁小管腔構造と局所心臓周囲脂肪内炎症との関連,
第66回日本心臓病学会学術集会, 2018年9月. Yukina Hirata, Hirotsugu Yamada, Kenya Kusunose, Susumu Nishio, Hrada Osamu, Miyasato Naomi, Hrakuni Atsusi, Ito Nobuhiko, Koji Yamaguchi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Echocardiographic Evaluation of Epicardial Adipose Tissue Thickness in Patients with Coronary Artery Disease: A Multicenter Study,
第66回日本心臓病学会学術集会, Sep. 2018. 鳥居裕太, 楠瀬賢也, 西尾進, 松本力三, 平田有紀奈, 天野里江, 西條良仁, 坂東美佳, 山田博胤, 佐田政隆 :
深部静脈血栓症に対する各種DOACsの治療成績∼下肢静脈エコー検査を用いた検討∼,
第66回日本心臓病学会学術集会, 2018年9月. 西尾進, 楠瀬賢也, 鹿草宏, 平田有紀奈, 鳥居裕太, 天野里江, 山尾雅美, 西條良仁, 坂東美佳, 山田博胤, 佐田政隆 :
急性期脳卒中患者におけるB型ナトリウム利尿ペプチドの臨床的意義,
第66回日本心臓病学会学術集会, 2018年9月. 山口浩司, 若槻哲三, 西條良仁, 上野理絵, 川端豊, 坂東美佳, 伊藤浩敬, 轟貴史, 松浦朋美, 伊勢孝之, 楠瀬賢也, 飛梅威, 八木秀介, 山田博胤, 添木武, 佐田政隆 :
第三世代薬剤溶出性ステント留置後における局所凝固反応塗装ステント長の関連性,
第66回日本心臓病学会学術集会, 2018年9月. 平田有紀奈, 楠瀬賢也, 山田博胤, 鳥居裕太, 西尾進, 西條良仁, 坂東美佳, 伊勢孝之, 山口浩司, 添木武, 若槻哲三, 佐田政隆 :
過度に蓄積した心外膜下脂肪は薬剤溶出型ステント留置後の再狭窄を予測するマーカーとなる,
第66回日本心臓病学会学術集会, 2018年9月. 福田大受, 山口浩司, 楠瀬賢也, 八木秀介, 山田博胤, 若槻哲三, 添木武, 佐田政隆 :
活性型血液凝固第X因子が冠動脈硬化に与える影響,
第66回日本心臓病学会学術集会, 2018年9月. 伊藤浩敬, 添木武, 松浦朋美, 伊勢孝之, 楠瀬賢也, 飛梅威, 山口浩司, 八木秀介, 山田博胤, 若槻哲三, 佐田政隆 :
AVNRTアブレーション治療後に発生したJunctional Tachycardiaの1例,
第112回日本循環器学会中国・四国合同地方会, 2018年6月. 轟貴史, 若槻哲三, 山口浩司, 瀬野弘光, 數藤久美子, 西條良仁, 川端豊, 上野理絵, 伊藤浩敬, 松浦朋美, 楠瀬賢也, 伊勢孝之, 飛梅威, 八木秀介, 福田大受, 山田博胤, 添木武, 佐田政隆 :
EES留置3年後，術前に抗血小板剤中止しペパリン置換したにもかかわらず2枝同時ステント閉塞を起こした1例,
第112回日本循環器学会中国・四国合同地方会, 2018年6月. 清水郁子, 瀬野弘光, 楠瀬賢也, 山口浩司, 山田博胤, 若槻哲三, 添木武, 岩瀬俊, 黒部裕嗣, 北川哲也, 佐田政隆 :
一年の経過で急速に進行したCalcified Amorphous Tumor(CAT)に対し腫瘍摘出手術を行った一例,
第112回日本循環器学会中国・四国合同地方会, 2018年6月. Robert Zheng, 數藤久美子, 楠瀬賢也, 松浦朋美, 瀬野弘光, 西條良仁, 上野理絵, 川端豊, 坂東美佳, 伊藤浩敬, 轟貴史, 伊勢孝之, 飛梅威, 山口浩司, 八木秀介, 福田大受, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
薬物治療が著効したSLE関連心筋炎の一例,
第112回日本循環器学会中国・四国合同地方会, 2018年6月. 西條良仁, 楠瀬賢也, 山田博胤, 西尾進, 瀬野弘光, 數藤久美子, 川端豊, 上野理絵, 伊藤浩敬, 轟貴史, 松浦朋美, 伊勢孝之, 飛梅威, 山口浩司, 八木秀介, 添木武, 若槻哲三, 佐田政隆 :
アトラサイクリン系抗癌剤による心筋障害の局在性および化学療法関連心筋障害との関連の検討,
第112回日本循環器学会中国・四国合同地方会, 2018年6月. 松本力三, 西尾進, 鳥居裕太, 湯浅麻美, 平田有紀奈, 天野里江, 山尾雅美, 楠瀬賢也, 山田博胤, 佐田政隆 :
糖尿病性腎症の各病期における超音波像の比較,
超音波検査技術, Vol.43, No.Suppl., S131, 2018年6月. 湯浅麻美, 西尾進, 平田有紀奈, 鳥居裕太, 天野里江, 松本真依, 松本力三, 山尾雅美, 楠瀬賢也, 山田博胤, 佐田政隆 :
頸動脈プラーク潰瘍形成と神経学的症状の有無について,
超音波検査技術, Vol.43, No.Suppl., S189, 2018年6月. 平田有紀奈, 西尾進, 原田修, 宮里尚美, 原國督, 楠瀬賢也, 伊藤敦彦, 山田博胤, 佐田政隆 :
心外膜下脂肪厚計測の有用性の証明多施設共同研究,
超音波検査技術, Vol.43, No.Suppl., S143, 2018年6月. 鳥居裕太, 西尾進, 天野里江, 湯浅麻美, 松本力三, 平田有紀奈, 山尾雅美, 楠瀬賢也, 山田博胤, 佐田政隆 :
右腎原発悪性リンパ腫の1例,
超音波検査技術, Vol.43, No.Suppl., S233, 2018年6月. 平田有紀奈, 西尾進, 鳥居裕太, 天野里江, 山尾雅美, 西條良仁, 楠瀬賢也, 山田博胤, 佐田政隆 :
糖尿病患者の冠動脈有意狭窄予測における心外膜下脂肪厚計測の有用性,
超音波検査技術, Vol.43, No.3, 231-238, 2018年6月. 西尾進, 楠瀬賢也, 平田有紀奈, 鳥居裕太, 天野里江, 山尾雅美, 伊藤浩敬, 伊勢孝之, 山口浩司, 若槻哲三, 山田博胤, 佐田政隆 :
左上肢の脱力で脳卒中センターへ搬送された急性冠症候群の1例,
超音波検査技術, Vol.43, No.3, 363, 2018年6月. 松本力三, 鳥居裕太, 西尾進, 平田有紀奈, 天野里江, 徳永尚樹, 池亀彰茂, 楠瀬賢也, 山田博胤, 佐田政隆 :
深部静脈血栓症のスクリーニング検査におけるTATおよびD-dimerの検討,
静脈学, Vol.29, No.2, 290, 2018年5月. 西尾進, 楠瀬賢也, 山田博胤 :
心臓外の病変の検出を極める ∼腫瘤性病変，大血管疾患∼,
日本心エコー図学会第29回学術集会, 2018年4月. 山田博胤 :
心膜疾患の診断における心エコー法の重要性,
日本心エコー図学会第29回学術集会, 2018年4月. 天野理江, 楠瀬賢也, 數藤久美子, 山田博胤, 佐田政隆 :
ステロイドおよび免疫抑制剤治療により改善がえられたSLE関連心筋炎の1症例,
日本心エコー図学会第29回学術集会, 2018年4月. 西條良仁, 山田博胤, 楠瀬賢也, 坂東美佳, 瀬野弘光, 西尾進, 鳥居裕太, 平田有紀奈, 天野理江, 山尾雅美, 添木武, 佐田政隆 :
化学療法関連心機能障害(CTRCD)に対し内科的加療が奏功した乳癌患者の一例,
日本心エコー図学会第29回学術集会, 2018年4月. 坂東美佳, 桑畑絢也, 楠瀬賢也, 西條良仁, 西尾進, 平田有紀奈, 鳥居裕太, 佐田政隆, 山田博胤 :
サルコイドーシスにおける左室global longitudinal strainの臨床的意義,
日本心エコー図学会第29回学術集会, 2018年4月. 平田有紀奈, 楠瀬賢也, 山田博胤, 阿部美保, 坂東美佳, 西條良仁, 瀬野弘光, 西尾進, 鳥居裕太, 佐田政隆 :
自家末梢血幹細胞移植併用大量化学療法により長期生存が得られた心アミロイドーシスの1例,
日本心エコー図学会第29回学術集会, 2018年4月. 鳥居裕太, 楠瀬賢也, 瀬野弘光, 西條良仁, 坂東美佳, 西尾進, 平田有紀奈, 佐田政隆, 山田博胤 :
2009年・2016年のASE左室拡張不全ガイドラインを用いた心不全患者の再入院予測,
日本心エコー図学会第29回学術集会, 2018年4月. 楠瀬賢也, 山田博胤, 佐田政隆 :
心房細動による左室機能障害,
日本心エコー図学会第29回学術集会, 2018年4月. 楠瀬賢也, 山田博胤, 佐田政隆 :
僧帽弁逆流症におけるストレインイメージングの臨床的有用性,
日本心エコー図学会第29回学術集会, 2018年4月. 森田沙瑛, 西尾進, 林修司, 楠瀬賢也, 松本力三, 平田有紀奈, 鳥居裕太, 天野里江, 山尾雅美, 西條良仁, 山田博胤, 佐田政隆 :
SphygmoCor-XCELの使用経験∼HEM-9000AIとの比較∼,
第3回日本血管不全学会学術集会, 2018年4月. 平田有紀奈, 山田博胤, 楠瀬賢也, 坂東美佳, 西條良仁, 瀬野弘光, 西尾進, 鳥居裕太, 佐田政隆 :
メタボリックシンドローム関連疾患のマネージメントにおける超音波検査の役割各種脂肪組織厚とメタボリックシンドロームとの関連超音波検査を用いた検討,
超音波医学, Vol.45, No.Suppl., S197, 2018年4月. 山田博胤, 坂東美佳, 楠瀬賢也, 西條良仁, 平田有紀奈, 鳥居裕太, 天野里江, 山尾雅美, 西尾進, 佐田政隆 :
Point-of-care USのプロトコルを考えるホーカス・ポーカス FOCUSだけではないPOCUSの心エコー検査,
超音波医学, Vol.45, No.Suppl., S200, 2018年4月. 松本賢亮, 楠瀬賢也, 山田博胤, 健一平田 :
心不全診療における心臓超音波検査の活かし方下肢陽圧負荷装置を用いた心不全患者に対する前負荷予備能評価と，その臨床応用可能性,
超音波医学, Vol.45, No.Suppl., S256, 2018年4月. 西條良仁, 楠瀬賢也, 坂東美佳, 瀬野弘光, 西尾進, 平田有紀奈, 鳥居裕太, 天野里江, 山田博胤, 佐田政隆 :
Onco-Cardiologyにおける心血管超音波検査の活用法アントラサイクリン系抗癌剤による化学療法関連心筋障害の局在性評価,
超音波医学, Vol.45, No.Suppl., S258, 2018年4月. 鳥居裕太, 山田博胤, 西尾進, 松本力三, 平田有紀奈, 天野里江, 西條良仁, 坂東美佳, 楠瀬賢也, 佐田政隆 :
Onco-Cardiologyにおける心血管超音波検査の活用法担癌患者における癌種別の深部静脈血栓症有所見率とDダイマー値の検討,
超音波医学, Vol.45, No.Suppl., S260, 2018年4月. 山田博胤, 西條良仁, 楠瀬賢也, 坂東美佳, 鳥居裕太, 平田有紀奈, 天野里江, 山尾雅美, 西尾進, 佐田政隆 :
心臓超音波検査の最新技術:本当に必要なの? 今はなくても困らない，でも，あったら便利,
超音波医学, Vol.45, No.Suppl., S267, 2018年4月. 坂東美佳, 山田博胤, 楠瀬賢也, 西條良仁, 佐田政隆, 和宏西上 :
ERで求められる心血管超音波検査胸痛疾患での救急エコー心血管エコー検査による原因と血行動態の評価,
超音波医学, Vol.45, No.Suppl., S274, 2018年4月. 楠瀬賢也, 西條良仁, 山田博胤, 佐田政隆 :
負荷心臓超音波検査の活かし方・落とし穴(症例ベース) 症例から学ぶ負荷心臓超音波検査のピットフォール,
超音波医学, Vol.45, No.Suppl., S280, 2018年4月. 坂東美佳, 山田博胤, 楠瀬賢也, 西條良仁, 西尾進, 佐田政隆, 西上和宏 :
深部静脈血栓症診療にエコーをどう活かすか深部静脈血栓症診療に超音波検査をどう活かすか他のモダリティーとの役割分担,
超音波医学, Vol.45, No.Suppl., S448, 2018年4月. 山田博胤, 坂東美佳, 鳥居裕太, 平田有紀奈, 天野里江, 山尾雅美, 西尾進, 佐田政隆 :
血管エコー技の伝承教育システムを考える「創生期」から「成長期」に入った血管エコー検査,
超音波医学, Vol.45, No.Suppl., S523, 2018年4月. 鳥居裕太, 西尾進, 松本力三, 平田有紀奈, 天野里江, 西條良仁, 瀬野弘光, 楠瀬賢也, 山田博胤, 佐田政隆 :
深部静脈血栓症に対する直接経口抗凝固薬の治療効果下肢静脈エコー検査による検討,
超音波医学, Vol.45, No.Suppl., S600, 2018年4月. 天野里江, 鳥居裕太, 西尾進, 平田有紀奈, 松本力三, 楠瀬賢也, 山田博胤, 佐田政隆 :
浅側頭動脈にMonckeberg型の石灰化を認めた巨細胞性動脈炎の3症例,
超音波医学, Vol.45, No.Suppl., S766, 2018年4月. 西尾進, 楠瀬賢也, 平田有紀奈, 藤田幸那, 鳥居裕太, 天野里江, 山尾雅美, 西條良仁, 山田博胤, 佐田政隆 :
最新の心エコー装置および装置非依存性strain解析ソフトを用いたGLS計測の装置間差,
超音波医学, Vol.45, No.Suppl., S809, 2018年4月. Kenya Kusunose, Yoshihito Saijoh, Koji Yamaguchi, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Right Ventricular Function Predicts Beneficial Effects of Cardiac Rehabilitation in Patients with Chronic Heart Failure,
第82回日本循環器学会, Mar. 2018. Yuta Torii, Kenya Kusunose, Hirotsugu Yamada, Hiromitsu Seno, Yoshihito Saijoh, Susumu Nishio, hirata yukina and Masataka Sata :
Association of Left Ventricular Diastolic Function using American Society of Echocardiography Recommendation with Readmission in Patients with Heart Failure,
第82回日本循環器学会, Mar. 2018. Yoshihito Saijoh, Kenya Kusunose, Hirotsugu Yamada, Susumu Nishio, Yukina Hirata, Yuta Torii, Kumiko Sutou, 上野理絵, Yutaka Kawabata, Hiroyuki Itou, Takafumi Todoroki, Tomomi Matsuura, Takayuki Ise, Takeshi Tobiume, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Anthracyclines induce early changes in localized left ventricular dysfunction.,
第82回日本循環器学会, Mar. 2018. Takeshi Soeki, Tomomi Matsuura, Daiju Fukuda, Takeshi Tobiume, Kenya Kusunose, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Hirotsugu Yamada, Tetsuzo Wakatsuki and Masataka Sata :
C-type natriuretic peptide improves left ventricular diastolic dysfunction in HFpEF model rats.,
第82回日本循環器学会, Mar. 2018. Yutaka Kawabata, Takeshi Soeki, Takayuki Ise, Tomomi Matsuura, Yoshihito Saijoh, Takeshi Tobiume, Shusuke Yagi, Koji Yamaguchi, Hirotsugu Yamada, Tetsuzo Wakatsuki and Masataka Sata :
Effects of L-/N-type Calcium Channel Blocker on Proteinuria and Angiotensin -renin Feedback in Hypertensive Patients,
第82回日本循環器学会, Mar. 2018. Takayuki Ise, Shusuke Yagi, Yutaka Kawabata, Seno Hiromitsu, Kumiko Sutou, Yoshihito Saijoh, Rie Ueno, Hiroyuki Ito, Takafumi Todoroki, Tomomi Matsuura, Kenya Kusunose, Takeshi Tobiume, Koji Yamaguchi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Acute Hemodynamic Effect of Handgrip Stress in Patients with Chronic Heart Failure.,
第82回日本循環器学会, Mar. 2018. Yukina Hirata, Kenya Kusunose, Hirotsugu Yamada, Yuta Torii, Susumu Nishio, Hiromitsu Seno, Tomomi Matsuura, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Impact of Marathon Running on Left Atrial function in healthy trained volunteers,
第82回日本循環器学会, Mar. 2018. 鳥居裕太, 楠瀬賢也, 山田博胤, 瀬野弘光, 西條良仁, 西尾進, 平田有紀奈, 佐田政隆 :
退院前の推定左室充満圧および収縮期肺動脈圧は心不全患者の再入院と関連する,
第82回日本循環器学会, 2018年3月. Koji Yamaguchi, Tetsuzo Wakatsuki, Yutaka Kawabata, Hiroyuki Itou, Takafumi Todoroki, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Takeshi Tobiume, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Differential Response of Local Coagulation after Coronary Angioplasty with Paclitaxel.,
第82回日本循環器学会, Mar. 2018. Hiroyuki Ito, Kenya Kusunose, Hirotsugu Yamada, Hiromitsu Seno, Yoshihito Saijoh, Susumu Nishio, Yukina Hirata and Masataka Sata :
Association of Left Ventricular Diastolic Function using American Society of Echocardiography Recommendation with Readmission in Patients with Heart Failure.,
第82回日本循環器学会, Mar. 2018. Tetsuzo Wakatsuki, Koji Yamaguchi, Daiju Fukuda, Yutaka Kawabata, 轟貴史, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Takeshi Tobiume, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Growth of vasa vasorum is associated with local inflammation around coronary plaque in fresh cadavers.,
第82回日本循環器学会, Mar. 2018. Hiroyuki Ito, Tetsuzo Wakatsuki, Koji Yamaguchi, Daiju Fukuda, Yutaka Kawabata, 轟貴史, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Takeshi Tobiume, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Growth of Vasa Vasorum is Associated with Local Inflammation around Coronary Plaque in Fresh Cadavers(和訳中),
日本循環器学会学術集会抄録集, PJ007-3, Mar. 2018. Koji Yamaguchi, Tetsuzo Wakatsuki, Yutaka Kawabata, Hiroyuki Ito, 轟貴史, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Takeshi Tobiume, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Differential Response of Local Coagulation after Coronary Angioplasty with Paclitaxel(和訳中),
日本循環器学会学術集会抄録集, PJ022-1, Mar. 2018. Yutaka Kawabata, Takeshi Soeki, Takayuki Ise, Tomomi Matsuura, Kenya Kusunose, Takeshi Tobiume, Shusuke Yagi, Koji Yamaguchi, Hirotsugu Yamada, Tetsuzo Wakatsuki and Masataka Sata :
Effects of L-/N-type Calcium Channel Blocker on Proteinuria and Angiotensin II-renin Feedback in Hypertensive Patients(和訳中),
日本循環器学会学術集会抄録集, PJ067-4, Mar. 2018. 鳥居裕太, 楠瀬賢也, 山田博胤, 瀬野弘光, 西條良仁, 西尾進, 平田有紀奈, 佐田政隆 :
退院前の推定左室充満圧および収縮期肺動脈圧は心不全患者の再入院と関連する,
日本循環器学会学術集会抄録集, CP17-2, 2018年3月. 八木秀介, 伊勢孝之, 川端豊, 伊藤浩敬, 楠瀬賢也, 山口浩司, 山田博胤, 若槻哲三, 赤池雅史, 佐田政隆 :
経カテーテル大動脈弁植込み術を施した超高齢大動脈弁狭窄症の1例,
日本老年医学会四国地方会, 2018年2月. 平田有紀奈, 西尾進, 原田修, 宮里尚美, 原國督, 楠瀬賢也, 伊藤敦彦, 山田博胤, 佐田政隆 :
外膜下脂肪厚計測の有用性の証明~多施設共同研究~,
超音波検査技術, Vol.43, No.Suppl, S143, 2018年. 志村拓哉, 西條良仁, 山口浩司, 楠瀬賢也, 山田博胤, 瀬野弘光, 數藤久美子, 上野理絵, 川端豊, 伊藤浩敬, 轟貴史, 松浦朋美, 伊勢孝之, 飛梅威, 八木秀介, 添木武, 若槻哲三, 佐田政隆 :
下肢静脈血栓症の誘因となる下肢血流障害の検討-下肢静脈造影での検討-,
第111回日本循環器学会四国地方会, 2017年12月. 豊田直人, 轟貴史, 添木武, 瀬野弘光, 數藤久美子, 西條良仁, 上野理絵, 川端豊, 伊藤浩敬, 松浦朋美, 伊勢孝之, 楠瀬賢也, 飛梅威, 山口浩司, 福田大受, 八木秀介, 山田博胤, 若槻哲三, 佐田政隆 :
診断から40年後に治療しえた著明なBroad Kent束を有するWPW症候群の一例,
第111回日本循環器学会四国地方会, 2017年12月. 中野睦基, 川端豊, 添木武, 松浦朋美, 飛梅威, 瀬野弘光, 數藤久美子, 西條良仁, 上野理絵, 伊藤浩敬, 轟貴史, 楠瀬賢也, 伊勢孝之, 山口浩司, 八木秀介, 山田博胤, 若槻哲三, 佐田政隆 :
嚥下性失神に対して高級性ペースメーカー植え込み術が有効であった1例,
第111回日本循環器学会四国地方会, 2017年12月. 矢野哲弘, 松浦朋美, 數藤久美子, 瀬野弘光, 西條良仁, 上野理絵, 川端豊, 伊藤浩敬, 轟貴史, 伊勢孝之, 楠瀬賢也, 飛梅威, 山口浩司, 八木秀介, 福田大受, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
心房細動アブレーション後の医原性心房中隔欠損残存により右心不全症状をきたした一例,
第111回日本循環器学会四国地方会, 2017年12月. 西尾進, 楠瀬賢也, 山田博胤, 平田有紀奈, 鳥居裕太, 天野里江, 山尾雅美, 瀬野弘光, 西條良仁, 佐田政隆 :
心エコー図検査の精度管理∼自施設内における検査間誤差∼,
第65回日本心臓病学会学術集会, 2017年9月. 川端豊, 若槻哲三, 山口浩司, 伊藤浩敬, 福田大受, 伊勢孝之, 楠瀬賢也, 松浦朋美, 轟貴史, 廣野明, 飛梅威, 八木秀介, 山田博胤, 添木武, 佐田政隆 :
未固定遺体における管脈プラーク性状と局所周囲脂肪内炎症物質との関連,
第65回日本心臓病学会学術集会, 2017年9月. 天野里江, 山田博胤, 楠瀬賢也, 西尾進, 平田有紀奈, 鳥居裕太, 瀬野弘光, 西條良仁, 佐田政隆 :
頸動脈内膜中膜複合体厚にDPP4阻害薬シタグリプチンが及ぼす影響―アログリプチンからの切り替え試験,
第65回日本心臓病学会学術集会:大阪, 2017年9月. 山口浩司, 若槻哲三, 川端豊, 伊藤浩敬, 轟貴史, 松浦朋美, 楠瀬賢也, 飛梅威, 伊勢孝之, 八木秀介, 山田博胤, 添木武, 佐田政隆 :
Biodegradable polymer SESの慢性期局所血管反応の検討-Durable polymer SESとの比較-,
第65回日本心臓病学会学術集会, 2017年9月. 西條良仁, 楠瀬賢也, 山田博胤, 瀬野弘光, 西尾進, 伊藤浩敬, 轟貴史, 伊勢孝之, 松浦朋美, 飛梅威, 山口浩司, 八木秀介, 若槻哲三, 佐田政隆 :
経食道心エコー図検査の再検によりvegetationを同定しえた感染性心内膜炎の一例,
第65回日本心臓病学会学術集会, 2017年9月. 轟貴史, 八木秀介, 楠瀬賢也, 伊勢孝之, 西條良仁, 瀬野弘光, 廣野明, 松浦朋美, 福田大受, 山口浩司, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
膠原病患者での肺動脈楔入圧と左室拡張期末期圧の関係,
第65回日本心臓病学会学術集会, 2017年9月. 楠瀬賢也, 山田博胤, 佐田政隆 :
肺高血圧症に対する6分間ホ高付加心エコー図検査の実際,
第65回日本心臓病学会学術集会, 2017年9月. 平田有紀奈, 楠瀬賢也, 山田博胤, 桒畑絢也, 鳥居裕太, 天野里江, 西尾進, 瀬野弘光, 西條良仁, 瀬野弘光, 八木秀介, 添木武, 佐田政隆 :
フルマラソンが心房機能に与える影響について∼，心エコー図検査を用いた検討∼,
第65回日本心臓病学会学術集会, 2017年9月. 鳥居裕太, 西尾進, 楠瀬賢也, 西條良仁, 瀬野弘光, 松本力三, 平田有紀奈, 天野里江, 山田博胤, 佐田政隆 :
治療効果判定に超音波検査が有用であったIgG4関連動脈周囲炎の1例,
第65回日本心臓病学会学術集会, 2017年9月. 桒畑絢也, 山田博胤, 林修司, 楠瀬賢也, 西條良仁, 瀬野弘光, 西尾進, 平田有紀奈, 鳥居裕太, 森田沙瑛, 佐田政隆 :
左室・左房容積計測における Automated adaptive analytics algorithm を用いた3次元心エコー法と従来法との比較,
第65回日本心臓病学会学術集会, 2017年9月. 若槻哲三, 山口浩司, 福田大受, 川端豊, 伊藤浩敬, 伊勢孝之, 楠瀬賢也, 八木秀介, 山田博胤, 添木武, 佐田政隆 :
微小管腔構造を認める冠動脈壁の組織性状の評価-未固定遺体における検討-,
第65回日本心臓病学会学術集会, 2017年9月. 瀬野弘光, 楠瀬賢也, 西條良仁, 山田博胤, 平田有紀奈, 鳥居裕太, 天野里江, 山尾雅美, 西尾進, 佐田政隆 :
心臓リハビリテーションによる運動耐容能改善度の規定因子:心エコー図検査を用いた検討,
第65回日本心臓病学会学術集会, 2017年9月. Kenya Kusunose, Hirotsugu Yamada, Susumu Nishio, Yuta Torii, Yukina Hirata, Hiromitsu Seno, Yoshihito Saijoh, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Preload Stress Echocardiography Predicts Outcomes in Patients with Pre-served Ejection Fraction and Low Gradient Aortic Stenosis,
第65回日本心臓病学会学術集会, Sep. 2017. 荒瀬美晴, 飛梅威, 伊藤浩敬, 松浦朋美, 添木武, 瀬野弘光, 西條良仁, 川端豊, 轟貴史, 伊勢孝之, 楠瀬賢也, 山口浩司, 八木秀介, 山田博胤, 若槻哲三, 佐田政隆 :
薬物療法の継続が困難で頻脈誘発性心筋症を生じたが，カテーテルアブレーションにて合併症なく根治に成功した洞房リエントリー性頻拍の1例,
第255回徳島医学会学術集会, 2017年8月. 瀬野弘光, 添木武, 松浦朋美, 伊勢孝之, 楠瀬賢也, 山口浩司, 山田博胤, 若槻哲三, 佐田政隆 :
計算負荷試験で誘発された心室性期外収縮の一例,
第110回日本循環器学会中国・四国合同地方会, 2017年6月. 伊藤浩敬, 飛梅威, 添木武, 大櫛祐一郎, 瀬野弘光, 西條良仁, 川端豊, 轟貴史, 廣野明, 松浦朋美, 楠瀬賢也, 伊勢孝之, 山口浩司, 八木秀介, 山田博胤, 若槻哲三, 佐田政隆 :
左鎖骨下への植え込み型除細動器植え替え後に生じたTwiddler症候群の1例,
第110回日本循環器学会中国・四国合同地方会, 2017年6月. 川端豊, 伊勢孝之, 山口浩司, 若槻哲三, 楠瀬賢也, 松浦朋美, 八木秀介, 飛梅威, 山田博胤, 添木武, 川谷洋平, 荒瀬裕己, 黒部裕嗣, 藤本鋭貴, 北川哲也, 佐田政隆 :
肺癌術前にバルーン大動脈弁形成術を施行し良好な開大が得られた重症大動脈弁狭窄症の一例,
第110回日本循環器学会中国・四国地方会, 2017年6月. 西條良仁, 山田博胤, 楠瀬賢也, 西尾進, 大櫛祐一郎, 瀬野弘光, 原知也, 川端豊, 伊藤浩敬, 轟貴史, 廣野明, 松浦朋美, 伊勢孝之, 飛梅威, 山口浩司, 八木秀介, 添木武, 若槻哲三, 黒部裕嗣, 渡邉俊介, 佐田政隆 :
著名な心内膜肥厚を認めた acromegalic cardiomyopathy の一例,
第110回日本循環器学会中国・四国地方会, 2017年6月. 山田博胤, 楠瀬賢也, 佐田政隆 :
Preload Stress Echocardiography を用いた運動耐用能の評価,
日本超音波医学会第90回学術集会, 2017年5月. 山田博胤, 楠瀬賢也, 西條良仁, 佐田政隆 :
僧帽弁閉鎖不全症-重症度評価の落とし穴,
日本超音波医学会第90回学術集会, 2017年5月. 山田博胤, 楠瀬賢也, 西尾進, 佐田政隆 :
技師に求める心エコー図検査の報告書,
日本超音波医学会第90回学術集会, 2017年5月. 山田博胤, 楠瀬賢也, 佐田政隆 :
ポケットエコーを用いたFocused Cardiac Ultrasound(FoCUS),
日本超音波医学会第90回学術集会, 2017年5月. 楠瀬賢也, 山田博胤, 佐田政隆 :
症例から学ぶTR-PG計測のピットフォール,
日本超音波医学会第90回学術集会, 2017年5月. 楠瀬賢也, 山田博胤, 佐田政隆 :
肺高血圧症に対する負荷心エコーの積極活用,
日本超音波医学会第90回学術集会, 2017年5月. 楠瀬賢也, 山田博胤, 林修司, 伊勢孝之, 山口浩司, 八木秀介, 添木武, 若槻哲三, 佐田政隆 :
経食道心エコー図の再検査によりVegetationを同定しえた感染性心内膜炎の1例,
日本内科学会第116回四国地方会, 2017年5月. Gulinu Maimaituxun, 島袋充生, 平田有紀奈, 山口浩司, 八木秀介, 福田大受, 山田博胤, 添木武, 原田雅史, 佐田政隆 :
Epicardial adipose tissue thickness in left anterior descending artery predictict coronary atherosclerosis,
第17回日本NO学会学術集会, 2017年5月. 天野里江, 山田博胤, 山尾雅美, 平田有紀奈, 宮崎達志, 足立克仁, 佐田政隆 :
デュシェンヌ型筋ジストロフィー(DMD)保因者における心筋ストレインの検討,
日本心エコー図学会第28回学術集会, 2017年4月. 瀬野弘光, 山田博胤, 大櫛祐一郎, 西條良仁, 楠瀬賢也, 平田有紀奈, 天野里江, 鳥居裕太, 山尾雅美, 西尾進, 林修司, 佐田政隆 :
肺動脈内に可動性に富む腫瘍を認めた原発性肺動脈血管内膜肉腫の1例,
日本心エコー図学会第28回学術集会, 2017年4月. 鳥居裕太, 楠瀬賢也, 山田博胤, 大櫛祐一郎, 瀬野弘光, 西條良仁, 西尾進, 平田有紀奈, 天野里江, 佐田政隆 :
心疾患既往のない患者における非心臓手術前の心エコー図検査が術後生存率に与える影響,
日本心エコー図学会第28回学術集会, 2017年4月. 大櫛祐一郎, 楠瀬賢也, 瀬野弘光, 西條良仁, 山田博胤, 西尾進, 鳥居裕太, 天野里江, 山尾雅美, 添木武, 佐田政隆 :
左房圧上昇評価における新しいASEガイドラインによる評価法と従来の包括的評価法との比較,
日本心エコー図学会第28回学術集会, 2017年4月. 西條良仁, 山田博胤, 楠瀬賢也, 大櫛祐一郎, 瀬野弘光, 平田有紀奈, 鳥居裕太, 山尾雅美, 西尾進, 添木武, 佐田政隆 :
心房収縮期僧帽弁口血流速度の前負荷増大に対する反応性を用いた左房圧上昇の予測,
日本心エコー図学会第28回学術集会, 2017年4月. 西尾進, 楠瀬賢也, 桑畑絢也, 平田有紀奈, 鳥居裕太, 天野里江, 山尾雅美, 大櫛祐一郎, 瀬野弘光, 西條良仁, 山田博胤, 佐田政隆 :
糖尿病と左室global longitudinal strainおよび血管内皮機能との関連,
日本心エコー図学会第28回学術集会, 2017年4月. 平田有紀奈, 山田博胤, 楠瀬賢也, 清水陸登, 桑畑絢也, 鳥居裕太, 天野里江, 山尾雅美, 西尾進, 大櫛祐一郎, 瀬野弘光, 西條良仁, 佐田政隆 :
低CHADS₂スコア患者の左心耳機能・形態と血栓形成リスクとの関連,
日本心エコー図学会第28回学術集会, 2017年4月. 楠瀬賢也, 山田博胤, 西尾進, 西條良仁, 瀬野弘光, 大櫛祐一郎, 平田有紀奈, 鳥居裕太, 山尾雅美, 阿部美保, 佐田政隆 :
下肢陽圧負荷心エコー図法で算出したprojected AVAiを用いた低圧較差高度大動脈弁狭窄のリスク層別化,
日本心エコー図学会第28回学術集会, 2017年4月. 楠瀬賢也, 林修司, 西尾進, 山田博胤, 佐田政隆 :
ストレイン法による左房機能評価,
日本心エコー図学会第28回学術集会, 2017年4月. 楠瀬賢也, 山田博胤, 西尾進, 佐田政隆 :
心不全と肺高血圧症,
日本心エコー図学会第28回学術集会, 2017年4月. Hirotsugu Yamada, Kenya Kusunose, 天野里江, 西條良仁, 瀬野弘光, 西尾進, 平田有紀奈, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Effect of Sitagliptin on Left Ventricular Function in Patients with Type 2 Diabetes: A Subanalysis of the PROLOGUE Study,
第81回日本循環器学会学術集会, Mar. 2017. 鳥居裕太, Hirotsugu Yamada, Kenya Kusunose, 大櫛祐一郎, 瀬野弘光, 西條良仁, 西尾進, 天野里江, 松本力三 and Masataka Sata :
Comparison of the Effect on Deep Vein Thrombosis between Rivaroxaban and Edoxaban,
第81回日本循環器学会学術集会, Mar. 2017. 西條良仁, Hirotsugu Yamada, Kenya Kusunose, 西尾進, 瀬野弘光, 大櫛祐一郎, 高木恵理, 上野理絵, 原知也, 川端豊, 斎藤友子, 伊藤浩敬, 轟貴史, Tomomi Matsuura, Takayuki Ise, Takeshi Tobiume, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Impact of Left Atrial Ischemia on Left Atrial Reservoir Function in Patients with Old Myocardial Infarction,
第81回日本循環器学会学術集会, Mar. 2017. 平田有紀奈, Kenya Kusunose, Hirotsugu Yamada, 清水陸登, 鳥居裕太, 西尾進, 瀬野弘光, 西條良仁, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Quantitative Classification of Left Atrial Appendage is Superior to Visual Classification for Risk Stratification of Stroke in Atrial Fibrillation,
第81回日本循環器学会学術集会, Mar. 2017. 轟貴史, Shusuke Yagi, Kenya Kusunose, Hirotsugu Yamada, Takayuki Ise, Tomomi Matsuura, Takeshi Tobiume, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Serum Level of Lipoprotein (a) is a Risk Factor for Aortic Valve Sclerosis in Women,
第81回日本循環器学会学術集会, Mar. 2017. 大櫛祐一郎, Hirotsugu Yamada, Kenya Kusunose, 西條良仁, 瀬野弘光, Tomomi Matsuura, Takayuki Ise, Koji Yamaguchi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Accuracy of Diagnosis of Elevated Left Atrial Pressure Using Recommendation for the Evaluation of Left Ventricular Diastolic Function by Echocardiograph,
第81回日本循環器学会学術集会, Mar. 2017. Hirotsugu Yamada and Masataka Sata :
Role of Echocardiography in Diagnosis and Treatment of Infectious Endocarditis,
第81回日本循環器学会学術集会, Mar. 2017. 楠瀬賢也, 山田博胤, 西尾進, 平田有紀奈, 瀬野弘光, 西條良仁, 伊勢孝之, 山口浩司, 八木秀介, 添木武, 若槻哲三, 佐田政隆 :
Right Ventricular Myocardial Strain during Preload Augmentation is Associated with Exercise Capacity in Patients with Chronic Heart Failure,
第81回日本循環器学会学術集会, 2017年3月. Maimaituxun Gulinu, Michio Shimabukuro, Koji Yamaguchi, Shusuke Yagi, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Takeshi Tobiume, Daiju Fukuda, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Local Epicardial Adipose Tissue Thickness and Its Impact on Coronary Atherosclerosis,
第81回日本循環器学会学術集会, Mar. 2017. 鳥居裕太, 楠瀬賢也, 山田博胤, 大櫛祐一郎, 瀬野弘光, 西條良仁, 西尾進, 天野里江, 平田有紀奈, 佐田政隆 :
Perioperative Echocardiography before Major Elective Noncardiac Surgery Improves Postoperative Mortality Patients without Known Cardiovascular Disease,
第81回日本循環器学会学術集会, 2017年3月. 伊藤浩敬, 若槻哲三, 山口浩司, 福田大受, 川端豊, 轟貴史, 松浦朋美, 楠瀬賢也, 伊勢孝之, 飛梅威, 八木秀介, 山田博胤, 添木武, 佐田政隆 :
Lipid-rich Coronary Plaque is Associated with Local Inflammation in Adjacent Epicardial Adipose Tissue in Fresh Cadaveric Models,
第81回日本循環器学会学術集会, 2017年3月. Tetsuzo Wakatsuki, Koji Yamaguchi, 伊藤浩敬, Daiju Fukuda, 川端豊, 轟貴史, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Takeshi Tobiume, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
The Tissue Characteristics of Coronary Plaque with Microluminal Structures Identified by OCT Associated with Local Inflammatory Response in Fresh Cadavers,
第81回日本循環器学会学術集会, Mar. 2017. Koji Yamaguchi, Tetsuzo Wakatsuki, 伊藤浩敬, 川端豊, 轟貴史, Tomomi Matsuura, Kenya Kusunose, Takayuki Ise, Takeshi Tobiume, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Comparison of Local Coagulative Response after Coronary Angioplasty - First Generation DES vs Second Generation-DES vs Drug Coated Balloon -,
第81回日本循環器学会学術集会, Mar. 2017. 瀬野弘光, Kenya Kusunose, Hirotsugu Yamada, 西條良仁, 西尾進, 平田有紀奈, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Comparison of Right Ventricular Global Longitudinal Strain between Vender-dependent and Vender-independent Two-dimensional Speckle Tracking Software,
第81回日本循環器学会学術集会, Mar. 2017. 谷口実佑, Takeshi Soeki, Tomomi Matsuura, 佐藤裕紀, Takeshi Tobiume, 原知也, Kenya Kusunose, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Activated Factor X Signaling Pathway via Protease-Activated Receptor-2 is a Novel Therapeutic Target to Prevent Atrial Fibrillation,
第81回日本循環器学会学術集会, Mar. 2017. 上田浩之, 瀬野弘光, 伊勢孝之, 楠瀬賢也, 山口浩司, 山田博胤, 若槻哲三, 添木武, 東島潤, 佐田政隆 :
ベバシズマブ併用化学療法中に深部静脈血栓症および肺塞栓症を来した大腸癌の1例-血栓素因の検討も含めて,
第254回徳島医学会学術集会, 2017年2月. 山本清成, 轟貴史, 大櫛祐一郎, 上野理恵, 伊勢孝之, 瀬野弘光, 西條良仁, 高木恵理, 原知也, 川端豊, 斎藤友子, 伊藤浩敬, 松浦朋美, 飛梅威, 楠瀬賢也, 山口浩司, 八木秀介, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆, 門田友里, 西村正人, 苛原稔 :
PET/CTにて診断できた心サルコイドーシスの1例,
第254回徳島医学会学術集会, 2017年2月. 笠井明成, 原知也, 山田博胤, 添木武, 若槻哲三, 足立克仁, 佐田政隆 :
著明な刺激伝導系異常を呈したBecker型筋ジストロフィーの1例,
第254回徳島医学会学術集会(平成28年度冬期), 2017年2月. Maimaituxun Gulinu, 島袋充生, 平田有紀奈, 岩瀬俊, 髙尾正一郎, 松浦朋美, 八木秀介, 福田大受, 山田博胤, 添木武, 田端実, 森本喜久, 赤坂武, 田中正史, 高梨秀一郎, 佐田政隆 :
心臓バイパス手術症例におけるリスク要因の定量的解析:古典的および非古典的リスクの性差,
脳心血管抗加齢研究会2016, 2016年12月. Gulinu Maimaituxun, 島袋充生, 平田有紀奈, 岩瀬俊, 高尾正一郎, 松浦朋美, 伊勢孝之, 楠瀬賢也, 飛梅威, 山口浩司, 八木秀介, 福田大受, 山田博胤, 添木武, 若槻哲三, 原田雅史, 佐田政隆 :
局所心臓周囲脂肪厚の臨床的意義:冠動脈疾患での検討,
脳心血管抗加齢研究会2016, 2016年12月. 鈴木聖也, 山田博胤, 高木恵理, 高川由利子, 松浦朋美, 伊勢孝之, 平田有紀奈, 楠瀬賢也, 西條良仁, 瀬野弘光, 大櫛祐一郎, 西尾進, 山尾雅美, 鳥居裕太, 八木秀介, 山口浩司, 添木武, 若槻哲三, 佐田政隆 :
経食道心エコー検査により原因が究明された高齢発症の右心不全の1例,
第109回日本循環器学会四国地方会, 2016年12月. 高木恵理, 八木秀介, 伊勢孝之, 楠瀬賢也, 山口浩司, 山田博胤, 添木武, 若槻哲三, 佐田政隆, 高川由利子 :
右心不全の精査の過程で偶発的に見つかった冠静脈洞閉鎖および重複上大静脈の一例,
第109回日本循環器学会四国地方会, 2016年12月. 上田浩之, 瀬野弘光, 松浦朋美, 楠瀬賢也, 山口浩司, 山田博胤, 若槻哲三, 添木武, 東島潤, 佐田政隆 :
Bevacizumab併用化学療法中に深部静脈血栓症および肺塞栓症を発症した1例,
第109回日本循環器学会四国地方会, 2016年12月. 行重佐和香, 楠瀬賢也, 瀬野弘光, 西條良仁, 伊勢孝之, 八木秀介, 山口浩司, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
成人期に心不全症状を契機に発見された左室緻密化障害の一例,
第109回日本循環器学会四国地方会, 2016年12月. ロバートゼング, 西條良仁, 楠瀬賢也, 山田博胤, 轟貴史, 西尾進, 瀬野弘光, 高木恵理, 上野理絵, 原知也, 川端豊, 齋藤友子, 伊藤浩敬, 松浦朋美, 伊勢孝之, 飛梅威, 山口浩司, 八木秀介, 添木武, 若槻哲三, 佐田政隆 :
左上肢脱力を主訴に来院されたが心エコー図法を契機に急性冠症候群と診断しえた一例,
第109回日本循環器学会四国地方会, 2016年12月. 岡本恵暢, 原知也, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
重症心不全を呈したBecker型筋ジストロフィーの1家系,
日本内科学会第115回四国地方会, 2016年11月. 楠瀬賢也, 山田博胤, 西條良仁, 瀬野弘光, 大櫛祐一郎, 西尾進, 鳥居裕太, 平田有紀奈, 伊勢孝之, 八木秀介, 佐田政隆 :
肺高血圧症に対する運動負荷心エコー図法,
第53回日本臨床生理学会総会, 2016年10月. 西尾進, 齋藤裕, 鳥居裕太, 平田有紀奈, 山尾雅美, 松本力三, 岩本誠司, 髙尾正一郎, 山田博胤, 佐田政隆 :
巨大肝嚢胞の2切除例,
日本超音波医学会第26回四国地方会学術集会, 2016年10月. 鳥居裕太, 西尾進, 松本力三, 平田有紀奈, 山尾雅美, 郷司剛志, 髙尾正一郎, 岩本誠司, 山田博胤, 佐田政隆 :
当院における腎細胞癌膵転移6症例の超音波所見,
日本超音波医学会第26回四国地方会学術集会, 2016年10月. 鈴川理乃, 山田博胤, 平田有紀奈, 西尾進, 山尾雅美, 天野里江, 鳥居裕太, 西條良仁, 楠瀬賢也, 佐田政隆 :
異なる体位変換により左室流出路狭窄が重症化したS字状中隔の2症例,
日本超音波医学会第26回四国地方会学術集会, 2016年10月. 木村優希, 山田博胤, 松浦一義, 楠瀬賢也, 西條良仁, 西尾進, 山尾雅美, 天野里江, 平田有紀奈, 佐田政隆 :
僧帽弁口血流速波形の偽正常化パターンと心房機能低下パターンの鑑別,
日本超音波医学会第26回四国地方会学術集会, 2016年10月. 衣川尚知, 山田博胤, 西尾進, 山尾雅美, 鳥居裕太, 天野里江, 西條良仁, 林修司, 楠瀬賢也, 佐田政隆 :
酵素補充療法に対する反応性が異なる心ファブリー病の2例,
日本超音波医学会第26回四国地方会学術集会, 2016年10月. 西條良仁, 楠瀬賢也, 山田博胤, 瀬尾弘光, 天野里江, 山尾雅美, 西尾進, 黒部裕嗣, 渡邉俊介, 佐田政隆 :
Acromegalic cardiomyopathyの一例,
日本超音波医学会第26回四国地方会学術集会, 2016年10月. 瀬尾弘光, 山田博胤, 楠瀬賢也, 西條良仁, 平田有紀奈, 鳥居裕太, 天野里江, 山尾雅美, 西尾進, 佐田政隆 :
肺動脈内に可動性に富む巨大血栓を認めた慢性血栓閉塞性肺動脈高血圧症の一例,
日本超音波医学会第26回四国地方会学術集会, 2016年10月. 大櫛祐一郎, 楠瀬賢也, 西條良仁, 山田博胤, 西尾進, 鳥居裕太, 天野里江, 山尾雅美, 添木武, 佐田政隆 :
運動負荷心エコー図検査で肺高血圧症を診断しえた一例,
日本超音波医学会第26回四国地方会学術集会, 2016年10月. 八木秀介, 伊勢孝之, 西川幸治, 石井亜由美, 楠瀬賢也, 山口浩司, 松浦朋美, 飛梅威, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
心不全患者に対するAdaptive servo-ventilation装着下6分間歩行における運動耐容能改善効果,
第64回日本心臓病学会学術集会, 2016年9月. 鈴川理乃, 山田博胤, 楠瀬賢也, 西條良仁, 瀬野弘光, 衣川尚知, 平田有紀奈, 天野里江, 鳥居裕太, 山尾雅美, 西尾進, 松浦朋美, 飛梅威, 添木武, 佐田政隆 :
持続性心房細動の肺静脈隔離術後における左房機能の回復と再発との関連,
第64回日本心臓病学会学術集会, 2016年9月. 衣川尚知, 齋藤憲, 西尾進, 平田有紀奈, 天野里江, 山尾雅美, 鳥居裕太, 林修司, 阿部美保, 楠瀬賢也, 山田博胤, 佐田政隆 :
心電図P波の電気軸から肺高血圧症の診断は可能か∼心エコー法による検討∼,
第64回日本心臓病学会学術集会, 2016年9月. 山田博胤, 楠瀬賢也, 西條良仁, 瀬野弘光, 西尾進, 山尾雅美, 天野里江, 鳥居裕太, 平田有紀奈, 田中秀和, 松本賢亮, 大北裕, 佐田政隆 :
表在エコー検査と心エコー検査のコラボレーションにより感染性心内膜炎が迅速に診断できた僧帽弁逸脱症の1例,
第64回日本心臓病学会学術集会, 2016年9月. 鳥居裕太, 楠瀬賢也, 西尾進, 平田有紀奈, 天野里江, 山尾雅美, 林修司, 阿部美保, 山田博胤, 佐田政隆 :
非心臓手術前の心エコー検査は，入院期間および死亡率に影響を与えない,
第64回日本心臓病学会学術集会, 2016年9月. 瀬野弘光, 楠瀬賢也, 山田博胤, 西條良仁, 伊勢孝之, 山口浩司, 八木秀介, 添木武, 若槻哲三, 佐田政隆 :
心血管イベント発症高リスク患者における非侵襲的血管機能検査の有用性,
第64回日本心臓病学会学術集会, 2016年9月. 添木武, 高橋甲介, 松浦朋美, 楠瀬賢也, 伊勢孝之, 飛梅威, 山口浩司, 八木秀介, 福田大受, 山田博胤, 若槻哲三, 島袋充生, 佐田政隆 :
心筋虚血再灌流障害に対する新たな治療薬としてのC型ナトリウム利尿ペプチドの可能性,
第64回日本心臓病学会学術集会, 2016年9月. 西尾進, 山田博胤, 楠瀬賢也, 真鍋泰毅, 平田有紀奈, 鳥居裕太, 天野里江, 山尾雅美, 佐田政隆 :
心拍出量の増加が血流依存性血管拡張反応に及ぼす影響(若年健常者における検討),
第64回日本心臓病学会学術集会, 2016年9月. 西條良仁, 楠瀬賢也, 山田博胤, 瀬野弘光, 西尾進, 伊勢孝之, 八木秀介, 山口浩司, 添木武, 若槻哲三, 佐田政隆 :
下肢陽圧負荷心エコー検査により将来の左房圧上昇を予測できるか,
第64回日本心臓病学会学術集会, 2016年9月. 玉井利奈, 山田博胤, 坂東美佳, 天野里江, 鳥居裕太, 平田有紀奈, 西尾進, 楠瀬賢也, 佐田政隆 :
脂質低下療法に伴う頸動脈プラーク性状変化の定量化:頸動脈超音波画像のiPlaque解析を用いた検討,
第3回日本心血管脳卒中学会学術集会, 2016年6月. 原知也, 福田大受, 田中君枝, 東邦康智, 平田陽一郎, 八木秀介, 山田博胤, 添木武, 若槻哲三, 島袋充生, 佐田政隆 :
活性型第X凝固因子によるマクロファージ活性化を介した新しい動脈硬化進展機序の検討,
第2回日本心血管脳卒中学会学術集会, 2016年6月. 原知也, 山田博胤, 伊勢孝之, 楠瀬賢也, 飛梅威, 山口浩司, 八木秀介, 添木武, 若槻哲三, 佐田政隆 :
重症心不全を呈したBecker型筋ジストロフィーの1剖検例,
第108回日本循環器学会中国・四国合同地方会, 2016年6月. 原知也, 飛梅威, 伊勢孝之, 楠瀬賢也, 山口浩司, 八木秀介, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
心房細動アブレーション後に麻痺性胃拡張を来した一例,
第108回日本循環器学会中国・四国合同地方会, 2016年6月. 山上圭, 西條良仁, 楠瀬賢也, 山田博胤, 瀬野弘光, 原知也, 上野理絵, 門田宗之, 齋藤友子, 山﨑宙, 坂東左知子, 伊藤浩敬, 轟貴史, 松浦朋美, 伊勢孝之, 飛梅威, 山口浩司, 八木秀介, 添木武, 若槻哲三, 佐田政隆 :
生体腎移植後における腎静脈-外腸骨静脈間の血流動態変化が一因と考えられた深部静脈血栓症の一例,
第108回日本循環器学会中国・四国合同地方会, 2016年6月. 伊勢孝之, 八木秀介, 門田宗之, 瀬野弘光, 西條良仁, 上野理絵, 原知也, 齋藤友子, 山﨑宙, 坂東左知子, 伊藤浩敬, 轟貴史, 松浦朋美, 楠瀬賢也, 飛梅威, 山口浩司, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
循環器病棟入院患者における睡眠時無呼吸，夜間低酸素血症の合併 ∼連続パルスオキシメータを用いた解析∼,
第108回日本循環器学会中国・四国合同地方会, 2016年6月. 中鉢雅大, 山田聡, 林大知, 岩野弘幸, 山田博胤, 土肥薫, 瀬尾由広, 大手信之, 清水力, 筒井裕之 :
左室弛緩能と充満圧の予測精度:組織ドプラ単一定量指標と複数指標の総合評価の比較,
日本超音波医学会第89回学術集会, 2016年5月. 山尾雅美, 西尾進, 平田有紀奈, 鳥居裕太, 岩本誠司, 六車直樹, 山田博胤, 佐田政隆, 藤崎由紀子, 渡辺滋夫 :
膵臓原発性悪性リンパ腫の1例,
日本超音波医学会第89回学術集会, 2016年5月. 松浦一義, 山田博胤, 楠瀬賢也, 鈴川理乃, 平田有紀奈, 山尾雅美, 西尾進, 赤池雅史, 佐田政隆 :
医学生の心エコー実習におけるシミュレーター教育の効果,
日本超音波医学会第89回学術集会, 2016年5月. 鳥居裕太, 楠瀬賢也, 山田博胤, 西尾進, 平田有紀奈, 天野里江, 山尾雅美, 林修司, 佐田政隆 :
心房細動が三尖弁輪収縮期移動距離に及ぼす影響,
日本超音波医学会第89回学術集会, 2016年5月. 楠瀬賢也, 山田博胤, 鳥居裕太, 西尾進, 天野里江, 山尾雅美, 瀬野弘光, 西條良仁, 林修司, 佐田政隆 :
左室ストレイン値の不均衡を用いた頻脈性不整脈患者における左室収縮能改善の予測,
日本超音波医学会第89回学術集会, 2016年5月. 西條良仁, 山田博胤, 楠瀬賢也, 林修司, 鳥居裕太, 天野里江, 山尾雅美, 西尾進, 添木武, 佐田政隆 :
ハンドグリップ負荷心エコー検査が有用であった心房細動合併慢性心不全の1例,
日本超音波医学会第89回学術集会, 2016年5月. 山田博胤, 楠瀬賢也, 西條良仁, 瀬野弘光, 西尾進, 天野里江, 鳥居裕太, 平田有紀奈, 鈴川理乃, 佐田政隆 :
運動負荷誘発性肺高血圧症の診断基準:肺動脈圧上昇のみで診断してよいか?,
日本超音波医学会第89回学術集会, 2016年5月. 楠瀬賢也, 山田博胤, 佐田政隆 :
弁膜症における運動負荷心エコー図検査を用いた右心機能評価,
日本超音波医学会第89回学術集会, 2016年5月. 山田博胤, 楠瀬賢也, 西條良仁, 瀬野弘光, 西尾進, 山尾雅美, 鳥居裕太, 平田有紀奈, 佐田政隆 :
心房細動のE/A 上昇は左房収縮低下か?左室拡張末期圧上昇か?,
日本超音波医学会第89回学術集会, 2016年5月. 山田博胤, 楠瀬賢也, 西條良仁, 瀬野弘光, 佐田政隆 :
循環器系のpoint-of-care 超音波-超音波専門医の視点から,
日本超音波医学会第89回学術集会, 2016年5月. 松浦朋美, 添木武, 飛梅威, 上野理絵, 坂東左知子, 山田博胤, 若槻哲三, 佐田政隆, 早渕康信, 小野朱美 :
心房中隔起源の持続性心房頻拍により頻脈誘発性心筋症をきたした小児の1例,
日本内科学会第114回四国地方会, 2016年5月. 伊藤浩敬, 若槻哲三, 山口浩司, 伊勢孝之, 上野理絵, 齋藤友子, 八木秀介, 山田博胤, 添木武, 佐田政隆 :
シロリムス溶出ステント留置7年後に初めて造影剤ステント周囲滲み出し像を認めその後も増大を呈した1例,
日本内科学会第114回四国地方会, 2016年5月. 瀬野弘光, 山田博胤, 楠瀬賢也, 西條良仁, 佐田政隆, 西尾進, 山尾雅美, 鳥居裕太, 天野里江, 平田有紀奈 :
心サルコイドーシスの診断に2Dspeckle tracingが有用であった1例,
日本内科学会第114回四国地方会, 2016年5月. 瀬野弘光, 山田博胤, 楠瀬賢也, 西條良仁, 佐田政隆, 西尾進, 山尾雅美, 鳥居裕太, 天野里江, 平田有紀奈 :
左室内脂肪腫性過誤腫の1例,
日本内科学会第114回四国地方会, 2016年5月. 西條良仁, 山田博胤, 楠瀬賢也, 瀬野弘光, 伊勢孝之, 八木秀介, 山口浩司, 添木武, 若槻哲三, 佐田政隆 :
ペースメーカー植込み術後に等容拡張期の異常な左室中部流入血流を認めた1例,
日本内科学会第114回四国地方会, 2016年5月. 西條良仁, 山田博胤, 楠瀬賢也, 瀬野弘光, 伊勢孝之, 八木秀介, 山口浩司, 添木武, 若槻哲三, 佐田政隆 :
ハンドグリップ負荷心エコー検査が心房細動合併心不全の治療評価に有用であった1例,
日本内科学会第114回四国地方会, 2016年5月. 鳥居裕太, 西尾進, 平田有紀奈, 天野里江, 山尾雅美, 高松直子, 楠瀬賢也, 中島公平, 里見淳一郎, 山田博胤, 永廣信治, 佐田政隆 :
若年女性の再発性脳梗塞の原因と考えられた頸動脈分岐部膜様構造物の1例,
第57回日本神経学会学術大会, 2016年5月. 新井理沙, 山田博胤, 楠瀬賢也, 林修司, 西條良仁, 瀬野弘光, 西尾進, 山尾雅美, 天野里江, 鳥居裕太, 平田有紀奈, 佐田政隆, 春藤譲治 :
座位で顕性化した左室流出路狭窄の1例,
日本心エコー図学会第27回学術集会, 2016年4月. 鳥居裕太, 山田博胤, 楠瀬賢也, 西尾進, 平田有紀奈, 天野里江, 山尾雅美, 林修司, 阿部美保, 佐田政隆 :
左室内脂肪腫性過誤腫の1例,
日本心エコー図学会第27回学術集会, 2016年4月. 天野里江, 楠瀬賢也, 林修司, 西尾進, 平田有紀奈, 鳥居裕太, 山尾雅美, 瀬野弘光, 西條良仁, 阿部美保, 山田博胤, 佐田政隆 :
部分肺静脈還流異常を合併した上位静脈洞型心房中隔欠損症の1例,
日本心エコー図学会第27回学術集会, 2016年4月. 瀬野弘光, 山田博胤, 楠瀬賢也, 西條良仁, 平田有紀奈, 天野里江, 鳥居裕太, 山尾雅美, 西尾進, 林修司, 佐田政隆 :
経食道心エコー検査を用いたCHADS2スコア定値例における左心耳機能の検討,
日本心エコー図学会第27回学術集会, 2016年4月. 西尾進, 山田博胤, 楠瀬賢也, 鈴川理乃, 平田有紀奈, 鳥居裕太, 天野里江, 山尾雅美, 瀬野弘光, 西條良仁, 佐田政隆 :
降圧治療が心臓および血管に与える影響,
日本心エコー図学会第27回学術集会, 2016年4月. 楠瀬賢也, 山田博胤, 瀬野弘光, 西條良仁, 平田有紀奈, 西尾進, 佐田政隆 :
膠原病患者における6分間歩行距離悪化予測因子の検討,
日本心エコー図学会第27回学術集会, 2016年4月. 平田有紀奈, 山田博胤, 楠瀬賢也, 西條良仁, 瀬野弘光, 西尾進, 山尾雅美, 天野里江, 鳥居裕太, 佐田政隆 :
虚血性心疾患における心筋バイアビリティーと心外膜脂肪厚の関係,
日本心エコー図学会第27回学術集会, 2016年4月. 楠瀬賢也, 山田博胤, 瀬野弘光, 西條良仁, 平田有紀奈, 西尾進, 佐田政隆 :
下肢陽圧負荷心エコー法で評価した拡張期リザーブと運動耐容能との関連,
日本心エコー図学会第27回学術集会, 2016年4月. 楠瀬賢也, 山田博胤, 瀬野弘光, 西條良仁, 林修司, 西尾進, 山尾雅美, 天野里江, 鳥居裕太, 平田有紀奈, 添木武, 佐田政隆 :
弁膜症・肺高血圧症で使いこなす,
日本心エコー図学会第27回学術集会, 2016年4月. 山田博胤, 楠瀬賢也, 西條良仁, 瀬野弘光, 林修司, 西尾進, 山尾雅美, 天野里江, 鳥居裕太, 平田有紀奈, 添木武, 佐田政隆 :
肺高血圧症に対する負荷心エコー検査,
日本心エコー図学会第27回学術集会, 2016年4月. 楠瀬賢也, 佐藤光代, 山田博胤, 福田大受, 八木秀介, 島袋充生, 佐田政隆 :
心血管イベント発症高リスク患者における非侵襲的血管機能検査の予後予測能,
第1回日本血管不全学会学術集会, 2016年4月. Shusuke Yagi, Ken-ichi Aihara, Daiju Fukuda, A Takashima, Mika Bando, T Hara, Takayuki Ise, Kenya Kusunose, Koji Yamaguchi, Takeshi Tobiume, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Michio Shimabukuro, Masashi Akaike and Masataka Sata :
Reduced Ratio of Eicosapentaenoic Acid and Docosahexaenoic Acid to Arachidonic Acid is Associated with Early Onset of Acute Coronary Syndrome.,
第80回日本循環器学会学術集会, Mar. 2016. Koji Yamaguchi, Tetsuzo Wakatsuki, T Hara, M Kadota, R Ueno, Mika Bando, H Yamazaki, Y Saito, S Bando, Tomomi Matsuura, Kenya Kusunose, Takayuki Ise, Takeshi Tobiume, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Local Vascular Response after Paclitaxel Eluting Balloon Angioplasty Compared to Drug Eluting Stent Implantation in Stable Angina Patients.,
第80回日本循環器学会学術集会, Mar. 2016. S Bando, Takeshi Soeki, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Takeshi Tobiume, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Plasma Myeloperoxidase Activity is Associated with Atrial Substrate Remodeling in Patients with Atrial Fibrillation.,
第80回日本循環器学会学術集会, Mar. 2016. Michio Shimabukuro, Hirotsugu Yamada, Hirotsugu Kurobe, Y Hirata, Daiju Fukuda, Shusuke Yagi, Takeshi Soeki, Tetsuya Kitagawa and Masataka Sata :
Ezetimibe Reduces Epicardial Fat and Improves Cardiac Performance in Swine Fed a High-fat Diet: A Pathophysiological Role of Oxidized Cholesterols.,
第80回日本循環器学会学術集会, Mar. 2016. Tomomi Matsuura, Takeshi Soeki, Y Morimoto, S Bando, Takayuki Ise, Kenya Kusunose, Takeshi Tobiume, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Epicardial Adipose Tissue Produce Proinflammatory Cytokines and Influence the Pathogenesis of Atrial Fibrillation.,
第80回日本循環器学会学術集会, Mar. 2016. Y Hirata, Kenya Kusunose, Hirotsugu Yamada, Y Torii, S Nishio, Mika Bando, S Hayashi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Structural Remodeling of Left Atrial Appendage in Patients with Atrial Fibrillation.,
第80回日本循環器学会学術集会, Mar. 2016. Kenya Kusunose, Hirotsugu Yamada, S Nishio, Y Hirata, H Seno, Y Saijo, Takayuki Ise, Takeshi Tobiume, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki, B Griffin and Masataka Sata :
Echocardiographic Characteristics of Right Ventricular Size and Function are Associated with Cardiac Events in Sleep Apnea Syndrome.,
第80回日本循環器学会学術集会, Mar. 2016. 近藤大祐, 八木秀介, 伊勢孝之, 山口浩司, 若槻哲三, 楠瀬賢也, 松浦朋美, 飛梅威, 山田博胤, 添木武, 福田大受, 赤池雅史, 島袋充生, 佐田政隆 :
急性冠症候群発症時のイコサペント酸とドコサヘキサエン酸の血中濃度低下は慢性期冠動脈ステント内再狭窄の予測因子である,
第45回日本心脈管作動物質学会, 2016年2月. 高島啓, 福田大受, 田中君枝, 東邦康智, 平田陽一郎, 山田博胤, 添木武, 若槻哲三, 島袋充生, 佐田政隆 :
ω3系不飽和脂肪酸の脂質ラフト構造変化を介した抗動脈硬化作用の解明,
第45回日本心脈管作動物質学会, 2016年2月. 上田雄大, 島袋充生, Maimaituxun Gulinu, Salim Masdan Hotimah, 坂東左知子, 松浦朋美, 伊勢孝之, 楠瀬賢也, 飛梅威, 山口浩司, 岩瀬俊, 八木秀介, 福田大受, 山田博胤, 添木武, 若槻哲三, 原田雅史, 佐田政隆 :
冠症候群発症例における心臓周囲脂肪および腹部脂肪分布の検討,
第45回日本心脈管作動物質学会, 2016年2月. Maimaituxun Gulinu, 島袋充生, Salim Masdan Hotimah, 松浦朋美, 八木秀介, 福田大受, 山田博胤, 添木武, 田端実, 森本喜久, 赤坂武, 田中正史, 高梨秀一郎, 佐田政隆 :
冠動脈疾患と心臓周囲脂肪量:男女差の検討,
第45回日本心脈管作動物質学会, 2016年2月. G Maimaituxun, Michio Shimabukuro, HM Salim, Tomomi Matsuura, Shusuke Yagi, D Fukuda, Hirotsugu Yamada, Takeshi Soeki, M Tabata, Y Morimoto, T Akasaka, M Tanaka, S Takanashi and Masataka Sata :
EATV is determinant for coronary atherosclerosis in men, but not in women: Analysis from patients underwent coronary artery bypass surgery.,
CVMW 2015, Dec. 2015. 上野理絵, 飛梅威, 山口浩司, 八木秀介, 山田博胤, 添木武, 若槻哲三, 島袋充生, 佐田政隆 :
当院で出産まで管理しえた心室頻拍合併妊娠の2症例,
日本内科学会第113回四国地方会, 2015年12月. 長瀬襟加, 鳥居裕太, 西尾進, 平田有紀奈, 山尾雅美, 岩本誠司, 山田博胤, 六車直樹, 佐田政隆 :
好酸球性胆管炎の1例,
日本超音波検査学会第19回中国・四国第23回合同地方会学術集会, 2015年11月. 天野里江, 西尾進, 山尾雅美, 鳥居裕太, 平田有紀奈, 坂東美佳, 林修司, 楠瀬賢也, 山田博胤, 佐田政隆 :
内科的治療に苦渋した右心不全の1例,
日本超音波検査学会第19回中国・四国第23回合同地方会学術集会, 2015年11月. 伊勢孝之, 西條良仁, 三木浩和, 賀川久美子, 瀬野弘光, 上野理絵, 原知也, 齋藤友子, 坂東美佳, 坂東左知子, 伊藤浩敬, 松浦朋美, 山口浩司, 飛梅威, 八木秀介, 山田博胤, 添木武, 若槻哲三, 安倍正博, 佐田政隆 :
auto-PBSCT とBortezomibの併用が著効した高度心機能障害を伴う原発性心アミロイドーシスの1例,
第107回日本循環器学会四国地方会, 2015年11月. 門田宗之, 伊勢孝之, 楠瀬賢也, 瀬野弘光, 上野理絵, 原知也, 齋藤友子, 高島啓, 坂東美佳, 山﨑宙, 坂東左知子, 伊藤浩敬, 飛梅威, 山口浩司, 八木秀介, 山田博胤, 添木武, 若槻哲三, 黒部裕嗣, 北川哲也, 佐田政隆 :
静脈洞型心房中隔欠損を合併した高齢難治性心不全に対し修復術が奏功した一例,
第107回日本循環器学会四国地方会, 2015年11月. 坂東左知子, 添木武, 松浦朋美, 飛梅威, 瀬野弘光, 西條良仁, 門田宗之, 原知也, 上野理絵, 齋藤友子, 坂東美佳, 山﨑宙, 伊藤浩敬, 伊勢孝之, 楠瀬賢也, 山口浩司, 八木秀介, 山田博胤, 若槻哲三, 佐田政隆 :
心室瘤を形成した心サルコイドーシス患者の薬剤抵抗性VT storm に対しアブレーションを行った一例,
第107回日本循環器学会四国地方会, 2015年11月. 西尾進, 鳥居裕太, 楠瀬賢也, 平田有紀奈, 天野里江, 山尾雅美, 山﨑宙, 坂東美佳, 高尾正一郎, 山田博胤, 佐田政隆 :
運動負荷ABIおよび下肢動脈エコー検査が診断に有用であった膝窩動脈捕捉症候群の1症例,
第107回日本循環器学会四国地方会, 2015年11月. 西條良仁, 坂東美佳, 楠瀬賢也, 門田宗之, 伊勢孝之, 山田博胤, 西尾進, 山口浩司, 八木秀介, 添木武, 若槻哲三, 佐田政隆 :
ハンドグリップ負荷による心臓カテーテル検査および心エコー検査が治療評価に有用であった2例,
第107回日本循環器学会四国地方会, 2015年11月. 伊藤浩敬, 高島啓, 八木秀介, 瀬野弘光, 門田宗之, 原知也, 上野理絵, 齋藤友子, 山﨑宙, 坂東美佳, 坂東左知子, 松浦朋美, 楠瀬賢也, 伊勢孝之, 山口浩司, 飛梅威, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
重症筋無力症に対する免疫抑制療法中に生じた化膿性心膜炎の一例,
第107回日本循環器学会四国地方会, 2015年11月. 西條良仁, 齋藤友子, 山田博胤, 楠瀬賢也, 坂東美佳, 瀬野弘光, 門田宗之, 原知也, 上野理絵, 山﨑宙, 坂東左知子, 伊藤浩敬, 伊勢孝之, 山口浩司, 八木秀介, 岩瀬俊, 添木武, 若槻哲三, 佐田政隆 :
遅延造影MRI検査が診断の契機となった心アミロイドーシスの1例,
第107回日本循環器学会四国地方会, 2015年11月. 山下雄也, 伊勢孝之, 坂東美佳, 原知也, 高島啓, 山﨑宙, 齋藤友子, 坂東左知子, 楠瀬賢也, 飛梅威, 山口浩司, 八木秀介, 山田博胤, 添木武, 若槻哲三, 木下肇, 藤本鋭貴, 北川哲也, 佐田政隆 :
60歳代で発見され外科治療が奏功した大動脈縮窄症の1例,
第107回日本循環器学会四国地方会, 2015年11月. 近藤大祐, 八木秀介, 伊勢孝之, 山口浩司, 若槻哲三, 楠瀬賢也, 松浦朋美, 飛梅威, 山田博胤, 添木武, 福田大受, 赤池雅史, 島袋充生, 佐田政隆 :
急性冠症候群患者におけるスタチンのω3不飽和脂肪酸濃度へ影響,
第107回日本循環器学会四国地方会, 2015年11月. 加藤悠人, 飛梅威, 坂東左知子, 松浦朋美, 添木武, 瀬野弘光, 上野理絵, 門田宗之, 原知也, 齋藤友子, 高島啓, 山﨑宙, 坂東美佳, 伊藤浩敬, 伊勢孝之, 楠瀬賢也, 山口浩司, 八木秀介, 山田博胤, 若槻哲三, 佐田政隆 :
His束近傍に起源を認めるATP感受性心房頻拍7例に関する検討,
第107回日本循環器学会四国地方会, 2015年11月. 西尾進, 鳥居祐太, 平田有紀奈, 天野里江, 山尾雅美, 坂東美佳, 楠瀬賢也, 山田博胤, 佐田政隆 :
頚動脈模様構造物が脳梗塞の原因と考えられた若年女性の1例,
第56回日本脈管学会総会, 2015年10月. 西尾進, 鳥居祐太, 平田有紀奈, 天野里江, 山尾雅美, 坂東美佳, 山田博胤, 楠瀬賢也 :
頚動脈模様構造物が脳梗塞の原因と考えられた若年女性の1例,
第56回日本脈管学会総会, 2015年10月. 鳥居祐太, 西尾進, 平田有紀奈, 天野里江, 山尾雅美, 山﨑宙, 坂東美佳, 高尾正一郎, 楠瀬賢也, 山田博胤, 佐田政隆 :
解剖学的異常を認めない膝窩動脈補捉症候群の1症例,
第56回日本脈管学会総会, 2015年10月. M Kadota, Takayuki Ise, Shusuke Yagi, Kenya Kusunose, Hajime Kinoshita, Hirotsugu Kurobe, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Successful Surgical Repair of Aged Sinus Venous Connection : A Case Report,
第19回日本心不全学会学術集会, Oct. 2015. 西尾進, 鳥居裕太, 平田有紀奈, 山尾雅美, 山田眞一郎, 岩本誠司, 山田博胤, 六車直樹, 島田光生, 佐田政隆 :
正常肝に発症した巨大肝細胞癌の1例,
日本超音波医学会第25回四国地方会学術集会, 2015年10月. 鈴川理乃, 山田博胤, 西尾進, 鳥居裕太, 天野里江, 山尾雅美, 楠瀬賢也, 林修司, 添木武, 佐田政隆 :
高齢で心アミロイドーシスを発症した肥大型心筋症の一例,
日本超音波医学会第25回四国地方会学術集会, 2015年10月. 西條良仁, 山田博胤, 楠瀬賢也, 林修司, 坂東美佳, 天野里江, 西尾進, 山尾雅美, 添木武, 佐田政隆 :
等容拡張期に異常な左室中部流入血流を認めたペースメーカー植込み術後の1例,
日本超音波医学会第25回四国地方会学術集会, 2015年10月. 平田有紀奈, 山田博胤, 楠瀬賢也, 西尾進, 瀬野弘光, 山崎宙, 坂東美佳, 林修司, 佐田政隆 :
僧帽弁置換術後早期に発症した人工弁血栓症の1例,
日本超音波医学会第25回四国地方会学術集会, 2015年10月. 瀬野弘光, 坂東美佳, 山田博胤, 楠瀬賢也, 西條良仁, 林修司, 平田有紀奈, 天野里江, 西尾進, 佐田政隆 :
CHADS2スコアが低値の左心耳機能低下例についての検討,
日本超音波医学会第25回四国地方会学術集会, 2015年10月. 伊勢孝之, 若槻哲三, 山口浩司, 坂東美佳, 門田宗之, 八木秀介, 山田博胤, 添木武, 佐田政隆 :
PTSMA術後に左室流出路狭窄の急性増悪を認めたHOCMの1例,
ストラクチャークラブ・ジャパンライブデモンストレーション2015, 2015年9月. 山尾雅美, 西尾進, 平田有紀奈, 中川美砂子, 森本雅美, 武知浩和, 田所由紀子, 山田博胤, 佐田政隆, 丹黒章 :
超音波検査による乳癌化学療法の効果予測,
第35回日本乳腺甲状腺超音波医学会, 2015年9月. 長野広実, 添木武, 坂東左知子, 松浦朋美, 飛梅威, 楠瀬賢也, 伊勢孝之, 山口浩司, 八木秀介, 福田大受, 山田博胤, 若槻哲三, 島袋充生, 佐田政隆 :
心房細動発症の予測因子-心電学的側面と心エコー学的側面からの検討-,
第63回日本心臓病学会学術集会, 2015年9月. 堀家由貴, 山田博胤, 楠瀬賢也, 坂東美佳, 鳥居裕太, 平田有紀奈, 山尾雅美, 西尾進, 佐田政隆 :
心不全に対する薬物療法を行ったDuchenne型筋ジストロフィーの予後,
第63回日本心臓病学会学術集会, 2015年9月. 坂東左知子, 添木武, 飛梅威, 松浦朋美, 伊勢孝之, 楠瀬賢也, 山口浩司, 八木秀介, 山田博胤, 若槻哲三, 佐田政隆 :
薬剤抵抗性のPurkinje起源心室頻拍に対し，人工呼吸管理・PCPS装着下にカテーテルアブレーション治療を施行し，社会復帰に成功した若年例の一例,
第63回日本心臓病学会学術集会, 2015年9月. 瀬野弘光, 山田博胤, 楠瀬賢也, 坂東美佳, 西條良仁, 西尾進, 山尾雅美, 鳥居裕太, 平田有紀奈, 伊勢孝之, 八木秀介, 添木武, 若槻哲三, 佐田政隆 :
6分間歩行負荷心エコー検査を用いた運動負荷誘発性肺高血圧症例の検出とその特徴,
第63回日本心臓病学会学術集会, 2015年9月. 平田有紀奈, 山田博胤, 西尾進, 鳥居裕太, 天野里江, 山尾雅美, 坂東美佳, 林修司, 楠瀬賢也, 山口浩司, 添木武, 若槻哲三, 島袋充生, 佐田政隆 :
冠動脈疾患の非侵襲的診断における心臓周囲脂肪厚の付加的価値,
第63回日本心臓病学会学術集会, 2015年9月. 伊勢孝之, 楠瀬賢也, 松浦朋美, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
急性心筋梗塞後にBeckerⅠ型とⅢ型の心破裂をきたし，救命しえた一例,
第63回日本心臓病学会学術集会, 2015年9月. 西尾進, 山田博胤, 平田有紀奈, 西條良仁, 高川由利子, 坂東美佳, 林修司, 楠瀬賢也, 伊勢孝之, 山口浩司, 若槻哲三, 佐田政隆 :
冠攣縮性狭心症における心臓周囲脂肪厚の検討,
第63回日本心臓病学会学術集会, 2015年9月. 坂東美佳, 伊勢孝之, 山田博胤, 楠瀬賢也, 西尾進, 山口浩司, 八木秀介, 添木武, 若槻哲三, 佐田政隆 :
収縮期雑音を契機に発見された成人単純型大動脈縮窄症の1例,
第63回日本心臓病学会学術集会, 2015年9月. 山田博胤 :
メディカルスタッフセッション「Structural Heart Disease」僧帽弁閉鎖不全症の病態を理解する,
第63回日本心臓病学会学術集会, 2015年9月. 山田亮, 原知也, 八木秀介, 東島潤, 山田博胤, 添木武, 若槻哲三, 島田光生, 佐田政隆 :
下肢静脈血栓症を伴わない下大静脈限局型血栓症の1例,
第251回徳島医学会学術集会(平成27年度夏期), 2015年8月. 高島啓, 門田宗之, 山口浩司, 原知也, 齋藤友子, 坂東美佳, 坂東左知子, 松浦朋美, 伊勢孝之, 楠瀬賢也, 飛梅威, 八木秀介, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
IgA腎症の加療中に若年で発症した急性冠症候群の一例,
第106回日本循環器学会中国・四国合同地方会, 2015年6月. 西尾進, 鳥居裕太, 平田有紀奈, 天野里江, 山尾雅美, 坂東美佳, 林修司, 阿部美保, 楠瀬賢也, 山田博胤, 佐田政隆 :
左室流出路に棍棒状可動性腫瘤を認めた一例,
第106回日本循環器学会中国・四国合同地方会, 2015年6月. 山﨑宙, 山口浩司, 原知也, 高島啓, 坂東美佳, 齋藤友子, 坂東左知子, 松浦朋美, 楠瀬賢也, 伊勢孝之, 飛梅威, 八木秀介, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
右心不全を来した収縮性心膜炎合併心膜嚢胞の一例,
第106回日本循環器学会中国・四国合同地方会, 2015年6月. 山﨑宙, 八木秀介, 鳥居裕太, 天野里江, 西尾進, 原知也, 齋藤友子, 高島啓, 坂東美佳, 坂東左知子, 松浦朋美, 伊勢孝之, 楠瀬賢也, 飛梅威, 山口浩司, 山田博胤, 添木武, 若槻哲三, 島袋充生, 赤池雅史, 佐田政隆 :
深部静脈血栓症に対するエドキサバンの凝固因子に与える影響,
第106回日本循環器学会中国・四国合同地方会, 2015年6月. 山﨑宙, 八木秀介, 原知也, 高島啓, 坂東美佳, 齋藤友子, 坂東左知子, 松浦朋美, 伊勢孝之, 楠瀬賢也, 飛梅威, 山口浩司, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
家族性アミロイドポリニューロパチーを合併した心肥大の一例,
第106回日本循環器学会中国・四国合同地方会, 2015年6月. 坂東左知子, 添木武, 原知也, 齋藤友子, 坂東美佳, 山﨑宙, 高島啓, 松浦朋美, 伊勢孝之, 楠瀬賢也, 山口浩司, 飛梅威, 八木秀介, 山田博胤, 若槻哲三, 坂東正章, 佐田政隆 :
Brugada症候群に閉塞性肥大型心筋症を併発した一例,
第106回日本循環器学会中国・四国合同地方会, 2015年6月. 八木秀介, 山﨑宙, 楠瀬賢也, 伊勢孝之, 飛梅威, 山口浩司, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
肺アスペルギルス症に合併した肺動静脈血栓症の1例,
第106回日本循環器学会中国・四国合同地方会, 2015年6月. 山尾雅美, 山田博胤, 西尾進, 平田有紀奈, 鳥居裕太, 天野里江, 坂東美佳, 楠瀬賢也, 林修司, 三代裕一郎, 佐田政隆 :
連続性雑音を契機に発見された無症候性バルサルバ洞動脈瘤破裂の一例,
第106回日本循環器学会中国・四国合同地方会, 2015年6月. 瀬野弘光, 坂東美佳, 楠瀬賢也, 山田博胤, 高川由利子, 林修司, 齋藤友子, 山﨑宙, 高島啓, 坂東左知子, 松浦朋美, 伊勢孝之, 飛梅威, 山口浩司, 八木秀介, 添木武, 若槻哲三, 平田有紀奈, 西尾進, 島袋充生, 佐田政隆 :
CHADS2スコア低値例における左心耳機能の検討,
第106回日本循環器学会中国・四国合同地方会, 2015年6月. 飛梅威, 坂東左知子, 松浦朋美, 添木武, 今田久美子, 松本和久, 齋藤友子, 原知也, 高島啓, 山﨑宙, 坂東美佳, 伊勢孝之, 楠瀬賢也, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 若槻哲三, 赤池雅史, 佐田政隆 :
心房細動カテーテルアブレーションにおける放射線防護キャビンの放射線被爆低減効果について,
第106回日本循環器学会中国・四国合同地方会, 2015年6月. 楠瀬賢也, 山田博胤, ブライアングリフィン, 坂東美佳, 西條良仁, 西尾進, 伊勢孝之, 山口浩司, 八木秀介, 添木武, 若槻哲三, 佐田政隆 :
睡眠時呼吸障害患者の右室機能評価は予後予測において有用である,
第106回日本循環器学会中国・四国合同地方会, 2015年6月. 上野理絵, 坂東美佳, 山田博胤, 楠瀬賢也, 高川由利子, 瀬野弘光, 門田宗之, 原知也, 齋藤友子, 山﨑宙, 高島啓, 坂東左知子, 松浦朋美, 伊勢孝之, 飛梅威, 山口浩司, 八木秀介, 添木武, 若槻哲三, 島袋充生, 佐田政隆 :
間質性肺炎合併膠原病性肺高血圧症にボセンタンが奏功した1例,
第106回日本循環器学会中国・四国合同地方会, 2015年6月. 平田有紀奈, 山田博胤, 楠瀬賢也, 西尾進, 山尾雅美, 天野里江, 鳥居裕太, 鈴川理乃, 高川由利子, 坂東美佳, 林修司, 阿部美保, 坂東左知子, 松浦朋美, 飛梅威, 添木武, 佐田政隆 :
心房細動に対する肺静脈隔離術後における洞調律維持の予測∼心エコー検査を用いた検討∼,
第106回日本循環器学会中国・四国合同地方会, 2015年6月. 鈴木智子, 楠瀬賢也, 山田博胤, 坂東美佳, 西條良仁, 西尾進, 伊勢孝之, 山口浩司, 八木秀介, 添木武, 若槻哲三, 佐田政隆 :
IGg4関連疾患に伴う巨大冠動脈瘤および冠動脈周囲偽腫瘍を認めた1例,
第106回日本循環器学会中国・四国合同地方会, 2015年6月. 楠瀬賢也, 山田博胤, 坂東美佳, 西條良仁, 西尾進, 伊勢孝之, 山口浩司, 八木秀介, 岩瀬俊, 添木武, 若槻哲三, 佐田政隆 :
膠原病に伴う肺高血圧症の悪化予測:6分間歩行負荷心エコー図検査を用いた検討,
第106回日本循環器学会中国・四国合同地方会, 2015年6月. 原知也, 福田大受, 田中君枝, 東邦康智, 平田陽一郎, 八木秀介, 山田博胤, 添木武, 若槻哲三, 島袋充生, 佐田政隆 :
活性型第X凝固因子によるマクロファージ活性化を介した新しい動脈硬化進展機序の検討,
第2回日本心血管脳卒中学会学術集会, 2015年6月. 山﨑宙, 若槻哲三, 山口浩司, 八木秀介, 山田博胤, 添木武, 佐田政隆, 鹿草宏, 里見淳一郎, 永廣信治 :
広範前壁心筋梗塞発症早期に左心室内血栓を生じた2例,
第2回日本心血管脳卒中学会学術集, 2015年6月. 坂東左知子, 松浦朋美, 添木武, 飛梅威, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 若槻哲三, 佐田政隆 :
感染性心内膜炎から多発性脳塞栓発症により死亡に至った一例,
第2回日本心血管脳卒中学会学術集会, 2015年6月. 飛梅威, 坂東左知子, 松浦朋美, 添木武, 今田久美子, 松本和久, 原知也, 齋藤友子, 高島啓, 山﨑宙, 坂東美佳, 伊勢孝之, 楠瀬賢也, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 若槻哲三, 赤池雅史, 佐田政隆 :
心房細動カテーテルアブレーションにおける放射線防護キャビンの放射線被爆低減効果に関する検討,
第2回日本心血管脳卒中学会学術集会, 2015年6月. 天野里江, 山田博胤, 楠瀬賢也, 坂東美佳, 西尾進, 山尾雅美, 鳥居裕太, 平田有紀奈, 佐田政隆 :
高度僧帽弁輪石灰化による多発性脳梗塞の1例,
第2回日本心血管脳卒中学会学術集会, 2015年6月. 平田有紀奈, 山田博胤, 楠瀬賢也, 西尾進, 山尾雅美, 坂東美佳, 松浦朋美, 飛梅威, 添木武, 佐田政隆 :
心房細動に対する肺静脈隔離術後における洞調律維持の予測:経胸壁および3次元経食道心エコー検査を用いた検討,
第2回日本心血管脳卒中学会学術集会, 2015年6月. 山下雄也, 坂東美佳, 楠瀬賢也, 宮本亮介, 伊勢孝之, 山口浩司, 八木秀介, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
片麻痺および間代性痙攣でStroke Care Unit入室後に高度心機能低下をきたした1例,
第2回日本心血管脳卒中学会学術集会, 2015年6月. 鈴川理乃, 西尾進, 山田博胤, 發知淳子, 平田有紀奈, 山﨑宙, 楠瀬賢也, 佐田政隆 :
透析シャント造設後に失神を繰り返した鎖骨下動脈盗血症候群の一例,
第2回日本心血管脳卒中学会学術集会, 2015年6月. 坂東美佳, 山田博胤, 楠瀬賢也, 平田有紀奈, 天野里江, 西尾進, 高川由利子, 林修司, 永廣信治, 佐田政隆 :
CHADS2スコア低値症例における左心耳機能の検討,
第2回日本心血管脳卒中学会学術集会, 2015年6月. 桑山一行, 羽星辰哉, 八木謙次, 里見淳一郎, 永廣信治, 坂東美佳, 山田博胤, 佐田政隆 :
くも膜下出血に続発したタコつぼ型心筋症(Neurogenic stress cardiomyopathy)の検討,
第2回日本心血管脳卒中学会学術集会, 2015年6月. 曽我部周, 多田恵曜, 里見淳一郎, 桑山一行, 吉岡正太郎, 山口泉, 永廣信治, 山本伸昭, 山田博胤, 若槻哲三, 佐田政隆 :
当院における院内発症脳卒中症例の検討,
第2回日本心血管脳卒中学会学術集会, 2015年6月. 原知也, 八木秀介, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
アトピー性皮膚炎から感染性心内膜炎を来した1例,
日本内科学会第112回四国地方会, 2015年6月. 山田博胤, 坂東美佳, 佐田政隆 :
頚動脈plaque性状診断における脳神経超音波の信頼性-各種モダリティーとの比較から-超音波後方散乱信号を用いた頸動脈プラークの性状診断とその臨床応用,
第34回日本脳神経超音波学会総会, 2015年6月. 鳥居裕太, 西尾進, 楠瀬賢也, 玉井佑里恵, 坂東美佳, 山田博胤, 佐田政隆 :
各種抗凝固薬における深部静脈血栓退縮効果の検討,
日本超音波医学会第88回学術集会, 2015年5月. 西條良仁, 山田博胤, 林修司, 楠瀬賢也, 坂東美佳, 高川由利子, 西尾進, 天野里江, 佐田政隆 :
前負荷増大に対する心反応性に及ぼす左房機能の影響:陳旧性心筋梗塞例における下肢陽圧負荷を用いた検討,
日本超音波医学会第88回学術集会, 2015年5月. 楠瀬賢也, 山田博胤, 西尾進, 鳥居裕太, 天野里江, 林修司, 添木武, 佐田政隆 :
Automated Function Imaging の左室壁運動定量評価は心エコー初心者の判断の補助となる,
日本超音波医学会第88回学術集会, 2015年5月. 楠瀬賢也, 山田博胤, 西條良仁, 坂東美佳, 林修司, 山尾雅美, 鳥居裕太, 添木武, 佐田政隆 :
運動負荷後の右心機能指標は弁膜症の予後と関連する招待講演,
日本超音波医学会第88回学術集会, 2015年5月. 山田博胤, 楠瀬賢也, 坂東美佳, 林修司, 西尾進, 山尾雅美, 天野里江, 鳥居裕太, 添木武, 佐田政隆 :
左室の壁運動(e')と血流(E)の不整合は左室拡張末期圧の上昇を反映する．,
日本超音波医学会第88回学術集会, 2015年5月. 山田博胤, 楠瀬賢也, 林修司, 坂東美佳, 西條良仁, 西尾進, 山尾雅美, 鳥居裕太, 平田有紀奈, 添木武, 佐田政隆 :
心エコー・ドプラ法による左室拡張末期圧の推定は，心房細動でも可能か?,
日本超音波医学会第88回学術集会, 2015年5月. 中鉢雅大, 山田聡, 岩野弘幸, 山田博胤, 土肥薫, 瀬尾由広, 大手信之, 西田睦, 清水力, 筒井裕之 :
単一の定量指標とパターン分類による左室弛緩能と充満圧推定精度の比較,
日本超音波医学会第88回学術集会, 2015年5月. 鳥居裕太, 西尾進, 鈴川理乃, 平田有紀奈, 天野里江, 山尾雅美, 坂東美佳, 木下肇, 髙尾正一郎, 楠瀬賢也, 山田博胤, 佐田政隆 :
感染症心内膜炎が契機となった右脛骨腓骨動脈感染性動脈瘤の1例,
第40回日本超音波検査学会学術集会, 2015年5月. K Node, J Oyama, T Ishizu, M Nanasato, K Kodama, Y Bandoh, H Kamiya, K Kitagawa, S Ueda, H Tomiyama, Masataka Sata, K Maemura, Munehide Matsuhisa, T Inoue, Y Higashi, Hirotsugu Yamada, M Ishihara, A Yamashina, N Kashihara, Y Sato and T Murohara :
The Study to Evaluate the Effects of DPP-4 Inhibitor on Atherosclerosis in Patients with Diabetes Mellitus: PROLOGUE Study.,
第79回日本循環器学会学術集会, Apr. 2015. N Sawada, Hirotsugu Yamada, Kenya Kusunose, Takashi Iwase, Mika Bando, Y Saijo, Y Takagawa, S Nishio, Y Hirata and Masataka Sata :
Dynamic Features of Cross-sectional Area of Right Ventricular Outflow Tract in a Cardiac Cycle: A Multi-modality Study.,
第79回日本循環器学会学術集会, Apr. 2015. Koji Yamaguchi, Tetsuzo Wakatsuki, T Hara, Y Takagawa, Mika Bando, A Takashima, H Yamazaki, S Bando, Tomomi Matsuura, Kenya Kusunose, Takayuki Ise, Takeshi Tobiume, Shusuke Yagi, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Differential Local Vascular Responses after Implantation of Biolimus-Eluting and Everolimus-Eluting Stents Compared with Sirolimus-Eluting and Bare Metal Stents.,
第79回日本循環器学会学術集会, Apr. 2015. T Hara, Daiju Fukuda, K Tanaka, Y Higashikuni, Y Hirata, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Inhibition of Activated Factor X Attenuates Neointima Formation after Wire-Mediated Vascular Injury.,
第79回日本循環器学会学術集会, Apr. 2015. T Hara, Daiju Fukuda, K Tanaka, Y Higashikuni, Y Hirata, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Inhibition of Activated Factor X Attenuates Vascular Inflammation and Atherosclerosis in ApoE-deficient Mice.,
第79回日本循環器学会学術集会, Apr. 2015. Takeshi Soeki, Tomomi Matsuura, S Bando, Takeshi Tobiume, T Hara, A Takashima, Mika Bando, H Yamazaki, Y Saito, Takayuki Ise, Kenya Kusunose, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Antiarrhythmic and Antiapoptotic Effects of C-type Natriuretic Peptide in Rats with Myocardial Ischemia/Reperfusion.,
第79回日本循環器学会学術集会, Apr. 2015. 林大地, 山田聡, 中鉢雅大, 岩野弘幸, 榊原守, 渡辺清孝, 若見和明, 楠瀬賢也, 石津智子, 山田博胤, 土肥薫, 瀬尾由広, 大手信之, 三神大世, 筒井裕之 :
スペックルストレインを用いた左室充満圧の推定:長軸方向最大ストレイン値の有用性,
第26回日本心エコー図学会学術集会, 2015年3月. 楠瀬賢也, 山田博胤 :
下肢陽圧負荷心エコー法で評価した拡張期リザーブと運動耐容能との関連,
第26回日本心エコー図学会学術集会, 2015年3月. 天野里江, 山田博胤, 西尾進, 阿部美保, 楠瀬賢也, 坂東美佳, 山尾雅美, 鳥居裕太, 平田有紀奈, 佐田政隆 :
肺動脈弁を往来する転移性心臓腫瘍の1例,
第26回日本心エコー図学会学術集会, 2015年3月. 坂東美佳, 山田博胤, 高川由利子, 西條良仁, 楠瀬賢也, 林修司, 西尾進, 平田有紀奈, 鳥居裕太, 天野里江, 山尾雅美, 佐田政隆 :
キアリ網に捕捉された右房内血栓の1例,
第26回日本心エコー図学会学術集会, 2015年3月. 山尾雅美, 山田博胤, 西尾進, 平田有紀奈, 鳥居裕太, 天野里江, 高川由利子, 坂東美佳, 楠瀬賢也, 林修司, 三代裕一郎, 佐田政隆 :
連続性雑音を契機に発見された無症候性大動脈―右房トンネルの一例,
第26回日本心エコー図学会学術集会, 2015年3月. 西尾進, 山田博胤, 平田有紀奈, 鳥居裕太, 天野里江, 山尾雅美, 高川由利子, 坂東美佳, 林修司, 楠瀬賢也, 山口浩司, 若槻哲三, 佐田政隆 :
冠攣縮性狭心症における心臓周囲脂肪厚の意義∼超音波検査を用いた検討∼,
第26回日本心エコー図学会学術集会, 2015年3月. 平田有紀奈, 山田博胤, 西尾進, 鈴川理乃, 堀家由貴, 玉井祐里恵, 鳥居裕太, 天野里江, 山尾雅美, 高川由利子, 坂東美佳, 林修司, 楠瀬賢也, 佐田政隆 :
体位変換によって出現する左室流出路狭窄の1例,
第26回日本心エコー図学会学術集会, 2015年3月. 楠瀬賢也, 山田博胤, ブライアングリフィン, 西尾進, 坂東美佳, 平田有紀奈, 西條良仁, 天野里江, 鳥居裕太, 山尾雅美, 佐田政隆 :
左室駆出率の保たれた睡眠時呼吸障害患者における右室機能と予後との関連,
第26回日本心エコー図学会学術集会, 2015年3月. Kenya Kusunose, Hirotsugu Yamada, Mika Bando, 高川由利子, 西尾進, 天野里江, 平田有紀奈 and Masataka Sata :
A Case of IgG4-related Disease with Multiple Coronary Aneurysms and Pseudo-tumors,
第26回日本心エコー図学会学術集会, Mar. 2015. 山田博胤, 楠瀬賢也, 坂東美佳, 西尾進, 天野里江, 平田有紀奈, 佐田政隆, 平野豊, 谷口貢, 土肥薫, 山田典一 :
肺高血圧症に対する運動負荷心エコー法:運動負荷右心カテーテル法によるバリデーション,
第26回日本心エコー図学会学術集会, 2015年3月. 原知也, 福田大受, 田中君江, 東邦康智, 平田陽一郎, 八木秀介, 山田博胤, 添木武, 若槻哲三, 島袋充生, 佐田政隆 :
活性型第X凝固因子によるマクロファージ活性化を介した新しい動脈硬化進展機序の検討,
第44回日本心脈管作動物質学会, 2015年2月. 松本康平, 楠瀬賢也, 松本和久, 高川由利子, 坂東美佳, 發知淳子, 松浦朋美, 伊勢孝之, 飛梅威, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
動脈周囲炎をきたしたIgG4関連疾患の1例,
第250回徳島医学会学術集会(平成26年度冬期), 2015年2月. 鈴木智子, 山崎宙, 近藤彰, 高川由利子, 坂東美佳, 發知淳子, 松浦朋美, 楠瀬賢也, 伊勢孝之, 飛梅威, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
活動性を評価するにあたりPET-CTが特に有効であった心サルコイドーシスの1例,
第250回徳島医学会学術集会(平成26年度冬期), 2015年2月. 武井美貴子, 飛梅威, 坂東左知子, 松浦朋美, 添木武, 今田久美子, 松本和久, 高川由利子, 原知也, 高島啓, 齋藤友子, 山崎宙, 坂東美佳, 伊勢孝之, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 若槻哲三, 佐田政隆 :
生理的ペーシングへのモード変更が心不全の改善に有効であった房室ブロックの1例,
第250回徳島医学会学術集会(平成26年度冬期), 2015年2月. 鈴川理之, 衣川尚知, 松本真依, 堀家由貴, 玉井佑里恵, 西尾進, 平田有紀奈, 山田博胤, 楠瀬賢也, 佐田政隆, 齋藤憲 :
前負荷増大に対する右心系の反応性ー下肢陽圧負荷を用いた若年健常者における検討,
徳島県臨床検査技師会誌, 23, 2014年12月.

(キーワード): 下肢陽圧試験 / 前負荷増大 / 心筋ストレイン値

今田久美子, 伊勢孝之, 八木秀介, 高木恵理, 松本和久, 高川由利子, 原知也, 高島啓, 齋藤友子, 坂東美佳, 山﨑宙, 坂東左知子, 松浦朋美, 飛梅威, 山口浩司, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
慢性血栓塞栓性肺高血圧症にリオシグアトを使用した1症例,
第105回日本循環器学会四国地方会, 2014年12月. 伊勢孝之, 岩瀬俊, 高木恵理, 今田久美子, 松本和久, 高川由利子, 原知也, 齋藤友子, 高島啓, 山﨑宙, 坂東美佳, 坂東左知子, 松浦朋美, 飛梅威, 山口浩司, 八木秀介, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
心臓MRIガドリニウム遅延造影で検出できなかった心臓サルコイドーシス再燃の一例,
第105回日本循環器学会四国地方会, 2014年12月. 堀家由貴, 山田博胤, 玉井佑里恵, 平田有紀奈, 鳥居祐太, 天野里江, 西尾進, 山尾雅美, 高川由利子, 坂東美佳, 林修司, 楠瀬賢也, 宮崎達志, 足立克仁, 佐田政隆, 齋藤憲 :
左室収縮不全に対する薬物療法によってDuchenne型筋ジストロフィーの予後は改善したか,
第105回日本循環器学会四国地方会, 2014年12月. 平田有紀奈, 山田博胤, 西尾進, 堀家由貴, 玉井佑里恵, 鳥居祐太, 天野里江, 山尾雅美, 高川由利子, 坂東美佳, 林修司, 楠瀬賢也, 伊勢孝之, 山口浩司, 八木秀介, 岩瀬俊, 添木武, 若槻哲三, 佐田政隆 :
頸動脈プラークスコア，心臓周囲脂肪厚と冠動脈硬化の関連:超音波検査を用いた検討,
第105回日本循環器学会四国地方会, 2014年12月. 高島啓, 若槻哲三, 山口浩司, 松本和久, 今田久美子, 高木恵理, 高川由利子, 原知也, 齋藤友子, 山﨑宙, 坂東美佳, 坂東左知子, 松浦朋美, 伊勢孝之, 飛梅威, 八木秀介, 岩瀬俊, 山田博胤, 添木武, 佐田政隆 :
冠動脈完全閉塞性病変の治療後慢性期に形成された二重血行路をOCTで観察し得た一例,
第105回日本循環器学会四国地方会, 2014年12月. 八木秀介, 鳥居祐太, 伊勢孝之, 山口浩司, 飛梅威, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 島袋充生, 赤池雅史, 佐田政隆 :
突然の片側性下肢腫脹を呈した変形性関節症の2例,
第105回日本循環器学会四国地方会, 2014年12月. 楠瀬賢也, 山田博胤, ポポヴィッチゾラン, 伊勢孝之, 山口浩司, 八木秀介, 岩瀬俊, 添木武, 若槻哲三, 佐田政隆 :
無症候性僧帽弁逆流症と大動脈弁逆流症の自然経過,
第105回日本循環器学会四国地方会, 2014年12月. 坂東左知子, 添木武, 今田久美子, 松本和久, 原知也, 高島啓, 山﨑宙, 坂東美佳, 齋藤友子, 松浦朋美, 伊勢孝之, 楠瀬賢也, 飛梅威, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 若槻哲三, 佐田政隆 :
右室流出路心外膜起源が疑われた突発性心室期外収縮の一例,
第105回日本循環器学会四国地方会, 2014年12月. 稲垣太造, 八木秀介, 伊勢孝之, 山口浩司, 飛梅威, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 島袋充生, 赤池雅史, 佐田政隆 :
治療抵抗性本態性高血圧に対する利尿剤の効果-インダパミドが効果的であった2例の検討-,
第105回日本循環器学会四国地方会, 2014年12月. 富永真由, 伊勢孝之, 坂東美佳, 今田久美子, 松本和久, 高川由利子, 原知也, 齋藤友子, 高島啓, 山﨑宙, 坂東左知子, 松浦朋美, 飛梅威, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 坂東正章, 佐田政隆 :
超選択的コントラストエコーを併用し経皮的中隔心筋焼灼術を有効に施行し得た閉塞性肥大型心筋症の1例,
第105回日本循環器学会四国地方会, 2014年12月. 伊勢孝之, 岩瀬俊, 高川由利子, 楠瀬賢也, 山口浩司, 八木秀介, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
心臓サルコイドーシス再燃に対してメトトレキサートの併用が有効であった1例,
第111回日本内科学会四国地方会, 2014年11月. 平田有紀奈, 山田博胤, 西尾進, 堀家由貴, 玉井佑里恵, 鳥居裕太, 天野里江, 山尾雅美, 坂東美佳, 林修司, 楠瀬賢也, 佐田政隆 :
肺高血圧を伴う右肺動脈上行大動脈起始の1例,
JSS四国第20回地方会学術集会, 2014年10月. 山尾雅美, 西尾進, 鳥居裕太, 平田有紀奈, 笹田倫子, 髙尾正一郎, 六車直樹, 山田博胤, 島田光生, 佐田政隆 :
内部に嚢胞性変化を伴った肝過形成結節の1例,
第24回日本超音波医学会四国地方会学術集会, 2014年10月. 鳥居裕太, 西尾進, 山尾雅美, 平田有紀奈, 笹田倫子, 松本早代, 髙尾正一郎, 六車直樹, 山田博胤, 佐田政隆 :
胃壁内膿瘍穿通による肝膿瘍の1例,
第24回日本超音波医学会四国地方会学術集会, 2014年10月. 玉井佑里恵, 西尾進, 堀家由貴, 平田有紀奈, 鳥居裕太, 木下肇, 北川哲也, 發知淳子, 山田博胤, 佐田政隆 :
短期間にバイパス閉塞をきたしたLeriche症候群の1例,
第24回日本超音波医学会四国地方会学術集会, 2014年10月. 堀家由貴, 山田博胤, 玉井佑里恵, 平田有紀奈, 鳥居裕太, 天野里江, 坂東美佳, 西尾進, 山尾雅美, 佐田政隆 :
僧帽弁置換術が奏功したBecker型筋ジストロフィーに基づく拡張型心筋症の一例,
第24回日本超音波医学会四国地方会学術集会, 2014年10月. 澤田直子, 山田博胤, 楠瀬賢也, 林修司, 坂東美佳, 西條良仁, 高川由利子, 西尾進, 天野里江, 佐田政隆 :
3次元心エコー図検査が有用で3次元心エコー法を用いた右室流出路の心周期における形態変化の検討:造影CT検査との比較,
第24回日本超音波医学会四国地方会学術集会, 2014年10月. 高川由利子, 林修司, 山田博胤, 坂東美佳, 天野里江, 西尾進, 山尾雅美, 松浦朋美, 佐田政隆 :
ペースメーカー植込み術後より聴取された収縮期雑音の診断に3次元心エコー図検査が有用であった一例,
第24回日本超音波医学会四国地方会学術集会, 2014年10月. 原國督, 山田博胤, 澤田直子, 高川由利子, 坂東美佳, 西尾進, 天野里江, 鳥居裕太, 平田有紀奈, 佐田政隆 :
カラードプラ法では重症度を過小評価した人工弁置換術後大動脈弁逆流(AR)の2例,
第24回日本超音波医学会四国地方会学術集会, 2014年10月. 坂東美佳, 山田博胤, 髙川由利子, 林修司, 西尾進, 平田有紀奈, 天野里江, 鳥居裕太, 山尾雅美, 佐田政隆 :
インフルエンザ感染による心膜炎を合併した右房内クモの巣血栓の1例,
第24回日本超音波医学会四国地方会学術集会, 2014年10月. 天野里江, 山田博胤, 發知淳子, 坂東美佳, 西尾進, 山尾雅美, 鳥居裕太, 平田有紀奈, 原國督, 佐田政隆 :
IGg4 関連疾患に伴う巨大冠動脈瘤の1例,
第24回日本超音波医学会四国地方会学術集会, 2014年10月. 西條良仁, 山田博胤, 林修司, 楠瀬賢也, 坂東美佳, 澤田直子, 高川由利子, 西尾進, 天野里江, 佐田政隆 :
前負荷増大に対する心反応性に及ぼす左房機能の影響:陳旧性心筋梗塞例における下肢陽圧負荷を用いた検討,
第24回日本超音波医学会四国地方会学術集会, 2014年10月. 松浦朋美, 添木武, 西條良仁, 齋藤友子, 高島啓, 坂東美佳, 坂東左知子, 發知淳子, 伊勢孝之, 飛梅威, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 若槻哲三, 佐田政隆 :
筋強直性ジストロフィーに伴い二次性心筋症と心房頻拍を呈し，カテーテルアブレーションを施行した一例,
第62回日本心臓病学会学術集会, 2014年9月. 平田有紀奈, 山田博胤, 西尾進, 楠瀬賢也, 澤田直子, 高川由利子, 西條良仁, 坂東美佳, 發知淳子, 林修司, 添木武, 若槻哲三, 佐田政隆 :
心エコー法で計測する前室間溝心外膜脂肪厚はCTで計測した心外膜脂肪容積を反映する,
第62回日本心臓病学会学術集会, 2014年9月. 發知淳子, 山田博胤, 西條良仁, 坂東美佳, 高島啓, 伊勢孝之, 山口浩司, 八木秀介, 岩瀬俊, 添木武, 若槻哲三, 佐田政隆 :
薬剤抵抗性起立性調節障害に対する携帯型下肢陽圧装置の効果,
第62回日本心臓病学会学術集会, 2014年9月. 楠瀬賢也, 山田博胤, 西尾進, Zoran Popovic, 佐田政隆 :
無症候性大動脈弁閉鎖不全症における運動負荷心エコー図法の有用性,
第62回日本心臓病学会学術集会, 2014年9月. 西尾進, 山田博胤, 楠瀬賢也, 平田有紀奈, 西條良仁, 坂東美佳, 發知淳子, 林修司, 添木武, 若槻哲三, 佐田政隆 :
S字状中隔と各種血管検査指標との関連,
第62回日本心臓病学会学術集会, 2014年9月. 坂東左知子, 添木武, 飛梅威, 松浦朋美, 伊勢孝之, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 若槻哲三, 佐田政隆 :
ATP 感受性リエントリー性心房頻拍の2症例,
第62回日本心臓病学会学術集会, 2014年9月. 原知也, 若槻哲三, 山口浩司, 伊勢孝之, 飛梅威, 八木秀介, 岩瀬俊, 山田博胤, 添木武, 佐田政隆 :
十分な術前ヘパリン置換にもかかわらず超遅発性ステント血栓症を発症した症例の検討-OCT による観察から-,
第62回日本心臓病学会学術集会, 2014年9月. 坂東美佳, 山田博胤, 西尾進, 林修司, 發知淳子, 西條良仁, 楠瀬賢也, 伊勢孝之, 山口浩司, 八木秀介, 岩瀬俊, 添木武, 若槻哲三, 佐田政隆 :
心房細動症例におけるCHADS2 およびCHA2DS2-VASc スコアと左心耳血流速度の関連,
第62回日本心臓病学会学術集会, 2014年9月. 添木武, 坂東左知子, 松浦朋美, 飛梅威, 高島啓, 坂東美佳, 發知淳子, 伊勢孝之, 山口浩司, 八木秀介, 福田大受, 岩瀬俊, 山田博胤, 若槻哲三, 島袋充生, 佐田政隆 :
心房細動におけるmicroRNAと心房リモデリングおよび予後との関係,
第62回日本心臓病学会学術集会, 2014年9月. 西條良仁, 山田博胤, 西尾進, 坂東美佳, 發知淳子, 林修司, 澤田直子, 高川由利子, 平田有紀奈, 山口浩司, 岩瀬俊, 添木武, 若槻哲三, 佐田政隆 :
僧帽弁血流速波形の前負荷増大に対する反応性には左房機能が関与する,
第62回日本心臓病学会学術集会, 2014年9月. A Takashima, Daiju Fukuda, K Tanaka, Y Higashikuni, Y Hirata, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Combined administration of eicosapentaenoic acid and docosahexaenoic acid reduces atherosclerotic lesion in apolipoprotein E-deficient mice.,
ESC 2014, Aug. 2014. 富永真由, 伊勢孝之, 坂東美佳, 今田久美子, 松本和久, 高川由利子, 高木恵理, 西條良仁, 原知也, 齋藤友子, 高島啓, 山﨑宙, 坂東左知子, 松浦朋美, 發知淳子, 飛梅威, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 坂東正章, 佐田政隆 :
超選択的コントラストエコーを併用し経皮的中隔心筋焼灼術を有効に施行し得た閉塞性肥大型心筋症の一例,
第249回徳島医学会学術集会(平成26年度夏期), 2014年7月. 亀田香奈子, 伊勢孝之, 西條良仁, 今田久美子, 松本和久, 高川由利子, 高木恵理, 原知也, 齋藤友子, 高島啓, 山﨑宙, 坂東美佳, 坂東左知子, 松浦朋美, 發知淳子, 飛梅威, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 近藤剛, 佐田政隆 :
原発性アルドステロン症患者に高度冠攣縮を合併し心筋梗塞を発症した1症例,
第249回徳島医学会学術集会(平成26年度夏期), 2014年7月. 西條良仁, 伊勢孝之, 三木浩和, 賀川久美子, 原知也, 齋藤友子, 高島啓, 坂東美佳, 坂東左知子, 松浦朋美, 發知淳子, 山口浩司, 飛梅威, 八木秀介, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 奥村宇信, 藤永裕之, 佐田政隆 :
高度心機能障害を伴う原発性心アミロイドーシスに対しauto-PBSCTを施行し得た一例,
第104回日本循環器学会中国・四国合同地方会, 2014年7月. 澤田直子, 高川由利子, 發知淳子, 西條良仁, 高島啓, 坂東美佳, 山崎宙, 坂東左知子, 松浦朋美, 伊勢孝之, 飛梅威, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
心エコー検査による大動脈弁逆流の重症度判定が困難であった大動脈弁位生体弁機能不全の一例,
第104回日本循環器学会中国・四国合同地方会, 2014年7月. 原知也, 八木秀介, 伊勢孝之, 飛梅威, 山口浩司, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
大動脈解離の急性期降圧療法における経皮吸収型β1遮断薬の使用経験,
第104回日本循環器学会中国・四国合同地方会, 2014年7月. 鳥居裕太, 山田博胤, 西尾進, 平田有紀奈, 天野里江, 山尾雅美, 高川由利子, 西條良仁, 坂東美佳, 發知淳子, 林修司, 添木武, 若槻哲三, 佐田政隆 :
遺残坐骨動脈奇形に伴う浅大腿動脈閉塞の1例,
第104回日本循環器学会中国・四国合同地方会, 2014年7月. 坂東左知子, 添木武, 飛梅威, 松浦朋美, 今田久美子, 松本和久, 高木恵理, 西條良仁, 原知也, 齋藤友子, 高島啓, 坂東美佳, 山崎宙, 伊勢孝之, 發知淳子, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 若槻哲三, 佐田政隆 :
ATP感受性リエントリー性心房頻拍の一例,
第104回日本循環器学会中国・四国合同地方会, 2014年7月. 松浦朋美, 添木武, 松本和久, 今田久美子, 西條良仁, 高木恵理, 原知也, 齋藤友子, 高島啓, 坂東美佳, 山崎宙, 坂東左知子, 發知淳子, 伊勢孝之, 飛梅威, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 若槻哲三, 佐田政隆 :
心房頻拍と心不全を契機に発覚した筋強直性ジストロフィーの一例,
第104回日本循環器学会中国・四国合同地方会, 2014年7月. 坂東左知子, 添木武, 飛梅威, 松浦朋美, 齋藤友子, 高島啓, 坂東美佳, 山崎宙, 伊勢孝之, 發知淳子, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 若槻哲三, 阪田美穂, 早渕康信, 井上美紀, 森一博, 木下学, 佐田政隆 :
薬剤抵抗性特発性心室頻拍に対し，PCPS下にアブレーション治療を施行し，社会復帰に成功した若年例の一例,
第104回日本循環器学会中国・四国合同地方会, 2014年7月. 松本和久, 若槻哲三, 高島啓, 山口浩司, 西條良仁, 高木恵理, 原知也, 齋藤友子, 高川由利子, 山崎宙, 坂東美佳, 坂東左知子, 松浦朋美, 伊勢孝之, 發知淳子, 飛梅威, 八木秀介, 岩瀬俊, 山田博胤, 添木武, 佐田政隆 :
シロリムス溶出ステント留置7年後に初めて造影剤ステント周囲滲み出し像と局所凝固反応亢進を認めた一例,
第104回日本循環器学会中国・四国合同地方会, 2014年7月. 原知也, 若槻哲三, 山口浩司, 伊勢孝之, 飛梅威, 八木秀介, 岩瀬俊, 山田博胤, 添木武, 佐田政隆 :
十分な術前ヘパリン置換にもかかわらず超遅発性ステント血栓症を発症した症例-OCTによる観察からの検討-,
第104回日本循環器学会中国・四国合同地方会, 2014年7月. 今田久美子, 伊勢孝之, 原知也, 八木秀介, 岩瀬俊, 西條良仁, 小笠原梢, 高島啓, 坂東美佳, 坂東左知子, 松浦朋美, 發知淳子, 飛梅威, 山口浩司, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
心不全を合併した頻脈性心房細動にランジオロールを有効に使用することができた2症例,
第104回日本循環器学会中国・四国合同地方会, 2014年7月. 高川由利子, 八木秀介, 山田博胤, 林修司, 發知淳子, 坂東美佳, 山口浩司, 伊勢孝之, 飛梅威, 岩瀬俊, 添木武, 若槻哲三, 佐田政隆 :
母児ともに救命できた母児間輸血症候群と妊娠高血圧腎症に合併した急性心不全の一例,
第104回日本循環器学会中国・四国合同地方会, 2014年7月. 西尾進, 山田博胤, 真鍋泰毅, 佐藤光代, 平岡葉月, 河野裕美, 平田有紀奈, 天野里江, 西條良仁, 高川由利子, 坂東美佳, 發知淳子, 林修司, 添木武, 若槻哲三, 佐田政隆 :
血流量の増加は%FMDを増大させる,
第104回日本循環器学会中国・四国合同地方会, 2014年7月. 原知也, 伊勢孝之, 飛梅威, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
Vascular endothelial growth factor (VEGF)阻害薬の眼内投与中に急性冠症候群を発症した4症例の検討,
第104回日本循環器学会中国・四国合同地方会, 2014年7月. 山田博胤, 島袋充生, 佐田政隆 :
非侵襲的検査としてのFMDの特徴と課題,
第46回日本動脈硬化学会総会・学術集会, 2014年7月. 鳥居裕太, 西尾進, 平田有紀奈, 天野里江, 山尾雅美, 玉井佑里恵, 堀家由貴, 坂東美佳, 山田博胤, 佐田政隆 :
上肢に認めた先天性および後天性静脈瘤の2例,
第39回日本超音波検査学会学術集会, 2014年6月. 平田有紀奈, 西尾進, 堀家由貴, 玉井佑里恵, 鳥居裕太, 天野里江, 山尾雅美, 坂東美佳, 發知淳子, 林修司, 山田博胤, 佐田政隆 :
心外膜脂肪の肥厚が診断の契機となった冠攣縮性狭心症の1例,
第39回日本超音波検査学会学術集会, 2014年6月. 西尾進, 林修司, 山田博胤 :
左房のストレインを臨床に生かす(パネルディスカッション),
第39回日本超音波検査学会学術集会, 2014年6月. 齋藤友子, 伊勢孝之, 發知淳子, 山口浩司, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 後東久嗣, 佐田政隆 :
左室収縮不全と間質性肺炎に伴う肺高血圧症を合併した皮膚筋炎の1例,
第110回日本内科学会四国地方会, 2014年6月. 坂東左知子, 添木武, 飛梅威, 松浦朋美, 山口浩司, 山田博胤, 若槻哲三, 佐田政隆, 井野口卓, 折野俊介 :
左室前乳頭筋起源の特発性心室性不整脈の1例,
第110回日本内科学会四国地方会, 2014年6月. 齋藤友子, 伊勢孝之, 發知淳子, 山口浩司, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 佐田政隆, 後東久嗣 :
左室収縮不全と間質性肺炎に伴う肺高血圧症を合併した皮膚筋炎の1例,
第110回日本内科学会四国地方会, 2014年6月. 松浦朋美, 添木武, 山口浩司, 八木秀介, 福田大受, 岩瀬俊, 山田博胤, 若槻哲三, 島袋充生, 佐田政隆 :
心房高頻度刺激を行った糖尿病モデルラットにおける直接レニン阻害薬の内皮機能障害抑制効果,
第1回日本心血管脳卒中学会学術集会, 2014年6月. 坂東美佳, 山田博胤, 平尾麻衣子, 平田有紀奈, 西尾進, 高川由利子, 西條良仁, 林修司, 發知淳子, 里見淳一郎, 永廣信治, 佐田政隆 :
心房細動におけるCHADS2およびCHA2DS2-VAScスコアと左心耳血流速度の関連,
第1回日本心血管脳卒中学会学術集会, 2014年6月. 高松直子, 森敦子, 野寺裕之, 島谷佳光, 和泉唯信, 西尾進, 山尾雅美, 鳥居裕太, 山田博胤, 佐田政隆 :
筋萎縮性側索硬化症の診断における神経超音波検査の有用性,
第87回日本超音波医学会学術集会, 2014年5月. 堀家由貴, 山田博胤, 西尾進, 發知淳子, 林修司, 玉井佑里恵, 宮崎達志, 足立克人, 齋藤憲, 佐田政隆 :
Duchenne 型筋ジストロフィーにおける左心機能の経年変化,
第87回日本超音波医学会学術集会, 2014年5月. 發知淳子, 山田博胤, 木村恵理子, 坂東美佳, 林修司, 西條良仁, 西尾進, 添木武, 森一博, 佐田政隆 :
収縮期雑音の原因が仮性腱索と考えられた1例:ヴィオリンハート,
第87回日本超音波医学会学術集会, 2014年5月. 天野里江, 山田博胤, 發知淳子, 林修司, 坂東美佳, 西條良仁, 西尾進, 山尾雅美, 添木武, 佐田政隆 :
上行大動脈の拡大が機序の異なる体位変換性呼吸困難に関与したと思われる1例,
第87回日本超音波医学会学術集会, 2014年5月. 山尾雅美, 山田博胤, 西尾進, 平田有紀奈, 鳥居裕太, 天野里江, 高島啓, 發知淳子, 添木武, 佐田政隆 :
冠状静脈洞内に疣腫を認めた冠動静脈瘻の一例,
第87回日本超音波医学会学術集会, 2014年5月. 平尾麻衣子, 山田博胤, 發知淳子, 林修司, 坂東美佳, 西尾進, 山尾雅美, 鳥居裕太, 添木武, 佐田政隆 :
CHADS2およびCHA2DS2-VAScスコアの増加は左心耳血流速度の低下と関連する,
第87回日本超音波医学会学術集会, 2014年5月. 西尾進, 鳥居裕太, 山田博胤, 佐田政隆 :
下肢静脈領域,
第87回日本超音波医学会学術集会, 2014年5月. 鳥居裕太, 西尾進, 山尾雅美, 平田有紀奈, 發知淳子, 伊勢孝之, 髙尾正一郎, 六車直樹, 山田博胤, 佐田政隆 :
門脈圧亢進症および門脈・左胃静脈内血栓による巨大脾動脈瘤の1症例,
第87回日本超音波医学会学術集会, 2014年5月. 山田博胤, 西尾進, 發知淳子, 坂東美佳, 西條良仁, 佐田政隆 :
循環器領域の救急超音波診断∼胸痛の鑑別∼,
第87回日本超音波医学会学術集会, 2014年5月. 林大知, 山田聡, 中鉢雅大, 榊原守, 西野久雄, 岡田一範, 市川絢子, 村井大輔, 山田博胤, 土肥薫, 瀬尾由広, 大手信之, 三神大世, 筒井裕之 :
左室充満圧の推定におけるE/eの限界と長軸および円周方向グローバルストレインレートを用いた新たな指標の検討,
第25回日本心エコー図学会学術集会, 2014年4月. 中鉢雅大, 山田聡, 林大知, 榊原守, 西野久雄, 岡田一範, 市川絢子, 村井大輔, 山田博胤, 土肥薫, 瀬尾由広, 大手信之, 西田睦, 澁谷斉, 清水力, 三神大世, 筒井裕之 :
YIAセッション組織ドプラ法による左室弛緩能と充満圧の推定に及ぼす左室収縮機能と肥大の影響,
第25回日本心エコー図学会学術集会, 2014年4月. 平田有紀奈, 山田博胤, 西尾進, 山尾雅美, 鳥居裕太, 坂東美佳, 林修司, 發知淳子, 西條良仁, 添木武, 若槻哲三, 佐田政隆 :
頸動脈プラークスコアおよび心外膜脂肪厚により冠動脈狭窄が予測できるか?,
第25回日本心エコー図学会学術集会, 2014年4月. 發知淳子, 山田博胤, 西條良仁, 坂東美佳, 林修司, 木村恵理子, 平田有紀奈, 天野里江, 鳥居裕太, 山尾雅美, 西尾進, 佐田政隆 :
膠原病例における6分間の歩行後右房-右室圧較差の経年的変化,
第25回日本心エコー図学会学術集会, 2014年4月. 秋山晋一郎, 山田博胤, 發知淳子, 林修司, 坂東美佳, 西條良仁, 西尾進, 平田有紀奈, 山尾雅美, 佐田政隆 :
ルーチン検査における各種右室収縮期指標と三次元心エコー法により求めた右室駆出率との相関,
第25回日本心エコー図学会学術集会, 2014年4月. 坂東美佳, 山田博胤, 西尾進, 天野里江, 平田有紀奈, 山尾雅美, 鳥居裕太, 林修司, 發知淳子, 西條良仁, 佐田政隆 :
頸動脈プラークの組織性状評価による冠動脈ステントの再狭窄の予測:iPlaqueを用いた検討,
第25回日本心エコー図学会学術集会, 2014年4月. 山田博胤, 西尾進, 佐田政隆 :
遠隔診断を病診連携に活かす,
第25回日本心エコー図学会学術集会, 2014年4月. 西尾進, 山田博胤, 佐田政隆 :
日常診療での心エコー図による右心機能評価;様々な指標の解釈と問題点,
第25回日本心エコー図学会学術集会, 2014年4月. 西尾進, 山田博胤, 佐田政隆 :
先天性心疾患:結局のところ，どういう異常なのか?,
第25回日本心エコー図学会学術集会, 2014年4月. 山田博胤, 西尾進, 佐田政隆 :
ネットワーク時代の画像情報管理とTele-medicine,
第25回日本心エコー図学会学術集会, 2014年4月. 山尾雅美, 西尾進, 山田博胤, 佐田政隆 :
超音波センターで育成される "General sonographer'',
第25回日本心エコー図学会学術集会, 2014年4月. 山田博胤, 西尾進, 坂東美佳, 發知淳子, 西條良仁, 山尾雅美, 天野里江, 鳥居裕太, 平田有紀奈, 佐田政隆 :
血管エコー検査と心エコー検査のコラボレーション,
第25回日本心エコー図学会学術集会, 2014年4月. 坂東美佳, 山田博胤, 西尾進, 天野里江, 平田有紀奈, 山尾雅美, 鳥居裕太, 西條良仁, 林修司, 發知淳子, 岩瀬俊, 髙尾正一郎, 佐田政隆 :
心サルコイドーシスの左室局所心筋におけるガドリニウム遅延造影と収縮期ストレイン,
第25回日本心エコー図学会学術集会, 2014年4月. 平田有紀奈, Hirotsugu Yamada, 西尾進, 鳥居裕太, 山尾雅美, Mika Bando, 林修司, Junko Hotsuchi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
冠動脈硬化と関連するのはSubepicardial Fat か，Pericardil Fat か,
第78回日本循環器学会学術集会, Mar. 2014. 西尾進, Hirotsugu Yamada, 山尾雅美, 平田有紀奈, Kazuhiro Mori, 松岡優 and Masataka Sata :
心エコー検査による先天性心疾患スクリーニングの有用性:子育て支援イベントにおける12年間のまとめ,
第78回日本循環器学会学術集会, Mar. 2014. S Bando, Takeshi Soeki, T Matsuura, Takeshi Tobiume, T Hara, A Takashima, Mika Bando, K Ogasawara, Y Saito, Junko Hotsuchi, E Kimura, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Takashi Iwase, Daiju Fukuda, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Atrial late potentials and atrial substrate remodeling in patients with atrial fibrillation.,
第78回日本循環器学会学術集会, Mar. 2014. S Bando, Takeshi Soeki, T Hara, A Takashima, Mika Bando, K Ogasawara, Y Saito, T Matsuura, Junko Hotsuchi, E Kimura, Takayuki Ise, Takeshi Tobiume, Koji Yamaguchi, Shusuke Yagi, Takashi Iwase, Daiju Fukuda, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro, Kenji Kangawa and Masataka Sata :
Ghrelin ameliorates the progression of experimental autoimmune myocarditis.,
第78回日本循環器学会学術集会, Mar. 2014. S Hayashi, Hirotsugu Yamada, S Nishio, Junko Hotsuchi, Mika Bando and Masataka Sata :
Differentiation between hypertrophic cardiomyopathy and hypertensive heart disease using tricuspid annular motion velocity.,
第78回日本循環器学会学術集会, Mar. 2014. Koji Yamaguchi, Tetsuzo Wakatsuki, T Hara, K Ogasawara, Mika Bando, A Takashima, S Bando, T Matsuura, Takayuki Ise, Junko Hotsuchi, Takeshi Tobiume, Shusuke Yagi, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Differential responses of local coagulation after implantation of biolimus-eluting and everolimus-eluting stents compared with sirolimus-eluting and bare metal stents.,
第78回日本循環器学会学術集会, Mar. 2014. Mika Bando, Hirotsugu Yamada, S Nishio, Junko Hotsuchi, S Hayashi, E Kimura, Takayuki Ise, T Matsuura, Takeshi Tobiume, Koji Yamaguchi, Shusuke Yagi, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Parallel changes in sonographic characteristics of carotid and coronary plaques.,
第78回日本循環器学会学術集会, Mar. 2014. Takayuki Ise, Shusuke Yagi, Takashi Iwase, Masashi Akaike, A Takashima, Mika Bando, S Bando, T Matsuura, Junko Hotsuchi, Takeshi Tobiume, Koji Yamaguchi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Impact of cardiac rehabilitation on oxidized stress in patients with heart failure.,
第78回日本循環器学会学術集会, Mar. 2014. T Matsuura, Takeshi Soeki, R Ota, T Hara, Y Saito, K Ogasawara, A Takashima, Mika Bando, S Bando, Junko Hotsuchi, E Kimura, Takayuki Ise, Takeshi Tobiume, Koji Yamaguchi, Shusuke Yagi, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki and Masataka Sata :
Increased local production of c-type natriuretic peptide in patients with vasospastic angina.,
第78回日本循環器学会学術集会, Mar. 2014. Takeshi Soeki, S Bando, T Matsuura, Takeshi Tobiume, T Hara, R Ota, A Takashima, Mika Bando, K Ogasawara, Y Saito, Takayuki Ise, Junko Hotsuchi, E Kimura, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Relationship between local production of microRNA-328 and atrial substrate remodeling in atrial fibrillation.,
第78回日本循環器学会学術集会, Mar. 2014. 今田久美子, 八木秀介, 山口浩司, 若槻哲三, 伊勢孝之, 太田理絵, 門田宗之, 高島啓, 松浦朋美, 飛梅威, 岩瀬俊, 山田博胤, 添木武, 赤池雅史, 佐田政隆 :
心不全を合併した腎血管性高血圧に対する経皮的腎動脈形成術の有効性,
第248回徳島医学会学術集会, 2014年2月. 松本和久, 高島啓, 山口浩司, 若槻哲三, 西條良仁, 高木恵理, 原知也, 齋藤友子, 小笠原梢, 坂東美佳, 坂東左知子, 松浦朋美, 伊勢孝之, 發知淳子, 木村恵理子, 飛梅威, 八木秀介, 岩瀬俊, 山田博胤, 添木武, 佐田政隆 :
シロリムス溶出ステント留置7年後に初めて造影剤ステント周囲滲み出し像を認めた一例,
第248回徳島医学会学術集会, 2014年2月. 八木秀介, 粟飯原賢一, 赤池雅史, 松本幸子, 福田大受, 松浦朋美, 伊勢孝之, 山口浩司, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 島袋充生, 松本俊夫, 佐田政隆 :
DPP-4阻害薬の血糖降下作用に対する有効性予測因子,
第248回徳島医学会学術集会, 2014年2月. 坂東左知子, 添木武, 飛梅威, 松浦朋美, 西條良仁, 高木恵理, 原知也, 小笠原梢, 坂東美佳, 齋藤友子, 高島啓, 發知淳子, 木村恵理子, 伊勢孝之, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 若槻哲三, 坂東正章, 佐田政隆 :
Aorta-mitral continuityが起源の心房頻拍の一例,
第103回日本循環器学会四国地方会, 2013年12月. 發知淳子, 山田博胤, 原知也, 太田理絵, 高島啓, 坂東美佳, 小笠原梢, 坂東左知子, 松浦朋美, 伊勢孝之, 木村恵理子, 飛梅威, 山口浩司, 八木秀介, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
下肢陽圧負荷の効果があった薬剤抵抗性起立性低血圧の2症例,
第103回日本循環器学会四国地方会, 2013年12月. 高島啓, 八木秀介, 高木恵理, 木下肇, 神原保, 原知也, 太田理絵, 坂東美佳, 坂東左知子, 伊勢孝之, 松浦朋美, 發知淳子, 飛梅威, 山口浩司, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 木村建彦, 北川哲也, 佐田政隆 :
冠静脈洞に疣贅が認められた冠動静脈瘻を合併した感染性心内膜炎の一例,
第103回日本循環器学会四国地方会, 2013年12月. 生田奈央, 高島啓, 原知也, 伊勢孝之, 島袋充生, 西條良仁, 高木恵理, 太田理絵, 齋藤友子, 坂東美佳, 坂東左知子, 松浦朋美, 發知淳子, 飛梅威, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
心身症として見過ごされてきた体位性起立頻脈症候群を的確に診断・治療し得た1例,
第103回日本循環器学会四国地方会, 2013年12月. 西條良仁, 松浦朋美, 飛梅威, 添木武, 坂東左知子, 高木恵理, 太田理絵, 原知也, 小笠原梢, 齋藤友子, 高島啓, 坂東美佳, 發知淳子, 木村恵理子, 伊勢孝之, 八木秀介, 岩瀬俊, 山田博胤, 若槻哲三, 佐田政隆 :
上位共通路の存在が示唆され室房ブロックを伴っても持続する2種類の房室結節リエントリー性頻拍を認めた1例,
第103回日本循環器学会四国地方会, 2013年12月. 坂東左知子, 飛梅威, 添木武, 松浦朋美, 西條良仁, 高木恵理, 原知也, 小笠原梢, 坂東美佳, 齋藤友子, 高島啓, 發知淳子, 木村恵理子, 伊勢孝之, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 若槻哲三, 佐田政隆 :
AMI急性期のVT/VF stormに対しtriggered PVC ablation を施行した一例,
第103回日本循環器学会四国地方会, 2013年12月. 松浦朋美, 飛梅威, 添木武, 坂東左知子, 高木恵理, 西條良仁, 太田理絵, 原知也, 齋藤友子, 小笠原梢, 高島啓, 坂東美佳, 伊勢孝之, 發知淳子, 木村恵理子, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 若槻哲三, 佐田政隆 :
ペースメーカー植込みの是非に検討を要した洞心不全症候群の一例,
第103回日本循環器学会四国地方会, 2013年12月. 玉井佑里恵, 西尾進, 坂東美佳, 松浦朋美, 堀家由貴, 眞鍋泰毅, 友藤達陽, 平田有紀奈, 鳥居裕太, 天野里江, 山尾雅美, 林修司, 發知淳子, 木村恵理子, 山田博胤, 佐田政隆 :
たこつぼ型心筋症の回復期に左室壁肥厚を認めた2例,
第103回日本循環器学会四国地方会, 2013年12月. 堀家由貴, 坂東美佳, 太田理絵, 西尾進, 玉井佑里恵, 眞鍋泰毅, 友藤達陽, 平田有紀奈, 鳥居裕太, 天野里江, 山尾雅美, 林修司, 發知淳子, 木村恵理子, 山田博胤, 佐田政隆 :
複合先天性疾患術後の重症三尖弁閉鎖不全合併妊娠の1例,
第103回日本循環器学会四国地方会, 2013年12月. 鳥居裕太, 西尾進, 神原保, 友藤達陽, 玉井佑里恵, 堀家由貴, 眞鍋泰毅, 平田有紀奈, 天野里江, 山尾雅美, 坂東美佳, 林修司, 發知淳子, 木村恵理子, 山田博胤, 佐田政隆 :
左上肢Klippel Trenaunay Syndrome(KTS)に伴う血栓性静脈炎の1例,
第103回日本循環器学会四国地方会, 2013年12月. 石井亜由美, 西川幸治, 伊勢孝之, 八木秀介, 岩瀬俊, 門田宗之, 西條良仁, 高島啓, 松浦朋美, 發知淳子, 飛梅威, 山口浩司, 山田博胤, 添木武, 若槻哲三, 中山泰介, 赤池雅史, 加藤真介, 北川哲也, 佐田政隆 :
人工呼吸管理中の心不全症例に心臓リハビリテーションが有効に施行しえた症例,
第103回日本循環器学会四国地方会, 2013年12月. 伊勢孝之, 八木秀介, 岩瀬俊, 西條良仁, 高木恵理, 太田理絵, 門田宗之, 原知也, 小笠原梢, 高島啓, 坂東美佳, 坂東左知子, 松浦朋美, 發知淳子, 飛梅威, 山口浩司, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
当院でのAdaptive-Servo Ventilationが有効であった拡張障害心不全の症例検討,
第103回日本循環器学会四国地方会, 2013年12月. 木村恵理子, 山田博胤, 西尾進, 發知淳子, 林修司, 坂東美佳, 山尾雅美, 鳥居裕太, 平田有紀奈, 友藤達陽, 玉井佑里恵, 堀家由貴, 森一博, 佐田政隆 :
仮性腱索が収縮器雑音の原因と考えられた1例,
第103回日本循環器学会四国地方会, 2013年12月. 小笠原梢, 伊勢孝之, 山口浩司, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
Fallot四徴症に対する根治術施行30年後に左心不全を合併した1例,
第109回日本内科学会四国地方会, 2013年12月. 玉置俊輔, 原知也, 伊勢孝之, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
冠攣縮および器質的冠狭窄を合併したBuerger病の1例,
第109回日本内科学会四国地方会, 2013年12月. Takayuki Ise, Takashi Iwase, Hirotsugu Yamada, Shusuke Yagi, Takeshi Tobiume, Koji Yamaguchi, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Progression of a Case of Myocardial Damage Caused by Beckers Muscular Dystrophy.,
第17回日本心不全学会学術集会, Nov. 2013. 田畑良, 山田博胤, 西尾進, 井口明子, 三橋乃梨子, 小幡史明, 西田結香, 川人圭祐, 多田紗彩, 原田貴文, 梅谷一公, 伊藤潤, 中西嘉憲, 河南真吾, 湯浅志乃, 清水伸彦, 山口治隆, 河野光宏, 佐田政隆, 谷憲治, 坂東弘康 :
徳島大学病院超音波センターと徳島県立海部病院間の心エコーによる遠隔診断支援システムを運用して,
第13回日本プライマリ・ケア連合学会四国ブロック支部大会, 2013年10月. 西尾進, 山田博胤, 佐田政隆 :
脈管診療における血管診療技師(CVT)の役割∼四国の現状と展望∼,
第54回日本脈管学会総会, 2013年10月. 西條良仁, 山田博胤, 林修司, 西尾進, 發知淳子, 坂東美佳, 鳥居裕太, 天野里江, 添木武, 佐田政隆 :
僧房弁位人工弁機能不全の診断に3次元経食道心エコー検査が有用であった1例,
第23回日本超音波医学会四国地方会学術集会, 2013年10月. 鳥居裕太, 西尾進, 山尾雅美, 平田有紀奈, 笹田倫子, 伊勢孝之, 髙尾正一郎, 六車直樹, 山田博胤, 佐田政隆 :
巨大脾動脈瘤の1症例,
第23回日本超音波医学会四国地方会学術集会, 2013年10月. 平田有紀奈, 西尾進, 山尾雅美, 鳥居裕太, 笹田倫子, 大塚加奈子, 髙尾正一郎, 六車直樹, 山田博胤, 佐田政隆 :
十二指腸壁内血腫の1例,
第23回日本超音波医学会四国地方会学術集会, 2013年10月. 山尾雅美, 西尾進, 鳥居裕太, 平田有紀奈, 藤岡啓介, 小谷裕美子, 髙尾正一郎, 六車直樹, 山田博胤, 佐田政隆 :
カテーテル感染を契機に巨大脾腫をきたした一例,
第23回日本超音波医学会四国地方会学術集会, 2013年10月. 友藤達陽, 林修司, 西尾進, 發知淳子, 天野里江, 坂東美佳, 鳥居裕太, 平田有紀奈, 山田博胤, 佐田政隆 :
心膜から右室への浸潤が経時的に観察できた胸腺癌の一例,
第23回日本超音波医学会四国地方会学術集会, 2013年10月. 坂東美佳, 山田博胤, 發知淳子, 林修司, 西尾進, 平田有紀奈, 天野里江, 鳥居裕太, 山尾雅美, 佐田政隆 :
術前心エコー検査で診断された未破裂巨大Valsalva洞動脈瘤1例,
第23回日本超音波医学会四国地方会学術集会, 2013年10月. 眞鍋泰毅, 山田博胤, 西尾進, 坂東美佳, 平田有紀奈, 天野里江, 鳥居裕太, 發知淳子, 林修司, 佐田政隆 :
一過性の左室壁肥厚を認めたたこつぼ型心筋症の一例,
第23回日本超音波医学会四国地方会学術集会, 2013年10月. 太田理絵, 今田久美子, 八木秀介, 坂東左知子, 松浦朋美, 伊勢孝之, 發知淳子, 上田由佳, 飛梅威, 山口浩司, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
冠灌流域に合致しない心電図誘導にJ波を認めた急性冠症候群の一例,
第61回日本心臓病学会学術集会, 2013年9月. 太田理絵, 今田久美子, 八木秀介, 坂東左知子, 松浦朋美, 伊勢孝之, 發知淳子, 上田由佳, 飛梅威, 山口浩司, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
経皮的腎動脈形成術により難治性心不全が改善した両側腎動脈狭窄症の1例,
第61回日本心臓病学会学術集会, 2013年9月. 門田宗之, 伊勢孝之, 八木秀介, 岩瀬俊, 赤池雅史, 原知也, 太田理絵, 坂東美佳, 高島啓, 坂東左知子, 松浦朋美, 山口浩司, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
慢性心不全患者に対するトルバプタン投与における薬物血中濃度と利尿効果の検討,
第61回日本心臓病学会学術集会, 2013年9月. 伊勢孝之, 岩瀬俊, 赤池雅史, 西尾進, 山口浩司, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
Intramural Hematoma症例のUlcer Like Projection形成と拡大における穿通枝の重要性,
第61回日本心臓病学会学術集会, 2013年9月. 伊勢孝之, 岩瀬俊, 山田博胤, 坂東美佳, 西尾進, 山口浩司, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
Becker型筋ジストロフィーによる心筋障害の経過を観察し得た1例,
第61回日本心臓病学会学術集会, 2013年9月. 岩瀬俊, 髙尾正一郎, 太田理絵, 山口浩司, 赤池雅史, 伊勢孝之, 山田博胤, 添木武, 若槻哲三, 原田雅史, 佐田政隆 :
3ステラ非造影心臓MRI検査が左室内壁在血栓の検出ならびに治療方針決定に有用であった無症候性心筋虚血の1例,
第61回日本心臓病学会学術集会, 2013年9月. 岩瀬俊, 髙尾正一郎, 赤池雅史, 伊勢孝之, 八木秀介, 山口浩司, 山田博胤, 添木武, 若槻哲三, 西岡安彦, 原田雅史, 佐田政隆 :
左室収縮不全を伴う心サルコイドーシスと他の心疾患鑑別におけるガドリニウム遅延造影定量評価の有用性,
第61回日本心臓病学会学術集会, 2013年9月. 平田有紀奈, 山田博胤, 西尾進, 真鍋泰毅, 友藤達陽, 天野里江, 鳥居裕太, 山尾雅美, 坂東美佳, 林修司, 伊勢孝之, 山口浩司, 岩瀬俊, 添木武, 若槻哲三, 佐田政隆 :
冠動脈硬化症と各種脂肪厚との関連∼超音波検査を用いた検討∼,
第61回日本心臓病学会学術集会, 2013年9月. 山口浩司, 若槻哲三, 坂東美佳, 高島啓, 伊勢孝之, 岩瀬俊, 山田博胤, 添木武, 佐田政隆 :
Everolimus-eluting stent留置後における局所凝固反応とステント長の関連性,
第61回日本心臓病学会学術集会, 2013年9月. 安岡紗哉香, 山田博胤, 坂東美佳, 林修司, 西尾進, 天野里江, 平田有紀奈, 横倉航一, 伊勢孝之, 山口浩司, 岩瀬俊, 添木武, 若槻哲三, 佐田政隆 :
たこつぼ型心筋症の予後と回復過程に関する検討,
第61回日本心臓病学会学術集会, 2013年9月. 林修司, 山田博胤, 西尾進, 坂東美佳, 平田有紀奈, 伊勢孝之, 山口浩司, 岩瀬俊, 添木武, 若槻哲三, 佐田政隆 :
冠動脈疾患におけるAugmentation indexの臨床的有用性についての検討,
第61回日本心臓病学会学術集会, 2013年9月. 若槻哲三, 山口浩司, 伊勢孝之, 八木秀介, 岩瀬俊, 山田博胤, 添木武, 佐田政隆 :
OCTにてmicrochannel構造を認める冠動脈プラークの局所炎症性の評価,
第61回日本心臓病学会学術集会, 2013年9月. 添木武, 坂東左知子, 松浦朋美, 高島啓, 坂東美佳, 發知淳子, 伊勢孝之, 飛梅威, 山口浩司, 八木秀介, 福田大受, 岩瀬俊, 山田博胤, 若槻哲三, 島袋充生, 佐田政隆 :
心房細動におけるPentraxin3と心房リモデリングおよび予後との関係,
第61回日本心臓病学会学術集会, 2013年9月. 坂東左知子, 添木武, 植松悦子, 松浦朋美, 伊勢孝之, 發知淳子, 飛梅威, 山口浩司, 八木秀介, 岩瀬俊, 福田大受, 山田博胤, 若槻哲三, 島袋充生, 寒川賢治, 佐田政隆 :
自己免疫性心筋炎に対するグレリンの効果,
第61回日本心臓病学会学術集会, 2013年9月. 西尾進, 山田博胤, 平田有紀奈, 鳥居裕太, 天野里江, 山尾雅美, 真鍋泰毅, 友藤達陽, 坂東美佳, 林修司, 伊勢孝之, 山口浩司, 岩瀬俊, 添木武, 若槻哲三, 佐田政隆 :
各種血管機能検査指標における性差の影響,
第61回日本心臓病学会学術集会, 2013年9月. 今田久美子, 太田理絵, 八木秀介, 山口浩司, 若槻哲三, 岩瀬俊, 西條良仁, 高木恵理, 門田宗之, 原知也, 齋藤友子, 高島啓, 坂東美佳, 坂東左知子, 松浦朋美, 伊勢孝之, 發知淳子, 飛梅威, 山田博胤, 添木武, 佐田政隆, 春藤譲冶 :
経皮的腎動脈形成術により難治性心不全が改善したCardiac disturbance syndromeの1例,
第247回徳島医学会学術集会, 2013年8月. 生田奈央, 高島啓, 原知也, 伊勢孝之, 西條良仁, 高木恵理, 門田宗之, 太田理絵, 齋藤友子, 坂東美佳, 坂東左知子, 松浦朋美, 發知淳子, 飛梅威, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 佐田政隆, 島袋充生, 福田大受, 友竹正人 :
心身症として見過ごされていた体位性起立頻脈症候群を的確に診断・治療し得た一例,
第247回徳島医学会学術集会, 2013年8月. 門田宗之, 伊勢孝之, 八木秀介, 岩瀬俊, 太田理絵, 原知也, 高島啓, 坂東美佳, 坂東左知子, 松浦朋美, 發知淳子, 飛梅威, 山口浩司, 山田博胤, 添木武, 若槻哲三, 佐田政隆, 赤池雅史 :
慢性心不全における新規利尿薬tolvaptanの効果予測因子,
第247回徳島医学会学術集会, 2013年8月. 石井亜由美, 西川幸治, 加藤真介, 伊勢孝之, 八木秀介, 岩瀬俊, 上田由佳, 門田宗之, 高島啓, 飛梅威, 山口浩司, 山田博胤, 添木武, 若槻哲三, 佐田政隆, 中川泰介, 北川哲也, 赤池雅史 :
人工呼吸管理中に心臓リハビリを有効に施行しえた開心術後の心不全症例,
第247回徳島医学会学術集会, 2013年8月. 西尾進, 山田博胤, 山尾雅美, 平田有紀奈, 佐田政隆, 森一博, 松岡優 :
乳幼児に対する心エコー検査を用いた先天性心疾患のスクリーニング:子育て支援イベント12年間の成果,
第247回徳島医学会学術集会, 2013年8月. 西條良仁, 松浦朋美, 飛梅威, 添木武, 坂東左知子, 高木恵理, 太田理絵, 門田宗之, 原知也, 齋藤友子, 高島啓, 坂東美佳, 伊勢孝之, 發知淳子, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 若槻哲三, 佐田政隆, 三木延茂 :
室房ブロックを伴っても持続する2種類の房室結節リエントリー性頻拍を認め，上位共通路の存在が示唆された1例,
第247回徳島医学会学術集会, 2013年8月. 太田理絵, 八木秀介, 若槻哲三, 岩瀬俊, 西條良仁, 高木恵理, 門田宗之, 原知也, 齋藤友子, 高島啓, 坂東美佳, 坂東左知子, 松浦朋美, 伊勢孝之, 發知淳子, 飛梅威, 山口浩司, 山田博胤, 添木武, 佐田政隆, 今田久美子, 髙尾正一郎 :
急性期の心電図でJ波を認めた急性心筋梗塞の一例,
第247回徳島医学会学術集会, 2013年8月. 田畑良, 中西嘉憲, 河南真吾, 湯浅志乃, 清水伸彦, 山口治隆, 河野光宏, 谷憲治, 山田博胤, 西尾進, 井口明子, 小幡史明, 坂東弘康, 佐田政隆 :
徳島県立海部病院の徳島大学病院による遠隔診断支援システムについて,
第247回徳島医学会学術集会, 2013年8月. 平田有紀奈, 西尾進, 小笠原梢, 仁木敏之, 坂東美佳, 發知淳子, 中川摩耶, 玉井利奈, 弘田大智, 山田博胤, 佐田政隆 :
右房内浮遊血栓から肺動脈塞栓を来し保存的加療が奏功した1例,
第38回日本超音波検査学会学術集会, 2013年6月. 平田有紀奈, 西尾進, 山尾雅美, 鳥居裕太, 玉井利奈, 中川摩耶, 山田博胤, 佐田政隆 :
冠動脈疾患における前室間溝心外膜下脂肪厚の検討,
第38回日本超音波検査学会学術集会, 2013年6月. 山田博胤, 西尾進, 佐田政隆 :
超音波検査士に望む,
第38回日本超音波検査学会学術集会, 2013年6月. 玉井利奈, 西尾進, 山田博胤 :
心エコー検査でみる塞栓源,
第38回日本超音波検査学会学術集会, 2013年6月. 山田博胤 :
心エコー・ドプラ法の臨床∼Diastology 2013∼,
第38回日本超音波検査学会学術集会, 2013年6月. 坂東美佳, 山田博胤, 發知淳子, 佐田政隆, 西尾進, 天野里恵, 平田有紀奈, 里見淳一郎, 永廣信治, 玉井利奈 :
超音波Integrated backscatterカラーマッピング法を用いた頸動脈プラークの組織性状診断,
第32回日本脳神経超音波学会総会, 2013年6月. 八木秀介, 發知淳子, 山田博胤, 岩瀬俊, 伊勢孝之, 山口浩司, 添木武, 若槻哲三, 佐田政隆, 近藤剛史 :
高血圧・糖尿病・脂質異常症・脳心血管障害を合併した原発性副甲状腺機能亢進症の1例,
日本内科学会第108回四国地方会, 2013年6月. 坂東左知子, 山口浩司, 添木武, 太田理絵, 松浦朋美, 岩瀬俊, 山田博胤, 若槻哲三, 佐田政隆, 四宮秀美 :
恒久ペースメーカ植込み後に発見された無症候性内頚静脈血栓の1例,
日本内科学会第108回四国地方会, 2013年6月. 太田理絵, 山口浩司, 發知淳子, 八木秀介, 岩瀬俊, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
41歳で初めて診断された肺動静脈瘻合併右肺動脈上行大動脈起始症の1例,
日本内科学会第108回四国地方会, 2013年6月. 岸潤, 中川麻耶, 河野弘, 西尾進, 平田有紀菜, 山田博胤, 佐田政隆, 西岡安彦 :
膠原病の関節炎における腋窩リンパ節の超音波性状に関する検討,
第86回日本超音波医学会学術集会, 2013年5月. 西尾進, 山田博胤, 發知淳子, 平田有紀奈, 友藤達陽, 坂東美佳, 林修司, 添木武, 佐田政隆 :
イルベサルタンは腎末梢血管抵抗を改善する ∼腎血管エコー検査を用いた検討∼,
第86回日本超音波医学会学術集会, 2013年5月. 發知淳子, 山田博胤, 西尾進, 平田有紀奈, 坂東美佳, 林修司, 冨田紀子, 添木武, 佐田政隆 :
膠原病関連運動誘発性肺高血圧における右室機能の評価,
第86回日本超音波医学会学術集会, 2013年5月. 友藤達陽, 山田博胤, 西尾進, 坂東美佳, 發知淳子, 林修司, 平田有紀奈, 添木武, 添木武, 佐田政隆 :
心エコー法を用いた平均右房圧推定法の検証,
第86回日本超音波医学会学術集会, 2013年5月. 坂東美佳, 山田博胤, 西尾進, 平田有紀奈, 林修司, 發知淳子, 冨田紀子, 松浦朋美, 添木武, 佐田政隆 :
左房還流型左上大静脈遺残を伴うunroofed coronary sinusの1例,
第86回日本超音波医学会学術集会, 2013年5月. 林修司, 山田博胤, 發知淳子, 坂東美佳, 西尾進, 山尾雅美, 鳥居祐太, 平田有紀奈, 添木武, 佐田政隆 :
僧帽弁輸運動速波形と推定中心血圧を用いた左室-動脈連関の臨床的評価,
第86回日本超音波医学会学術集会, 2013年5月. 西尾進, 山田博胤, 佐田政隆 :
大学病院・中核病院における技師の教育,
第86回日本超音波医学会学術集会, 2013年5月. 山田博胤, 西尾進, 佐田政隆 :
スペックルトラッキング法を用いた右室機能の評価,
第86回日本超音波医学会学術集会, 2013年5月. 山田博胤, 西尾進, 坂東美佳, 發知淳子, 林修司, 平田有紀奈, 佐田政隆 :
心:その息切れ・・・・年のせい?心不全?,
第86回日本超音波医学会学術集会, 2013年5月. 平田有紀奈, 西尾進, 友藤達陽, 坂東美佳, 林修司, 發知淳子, 山田博胤, 添木武, 赤池雅史, 佐田政隆 :
超音波検査で計側した各種脂肪組織厚と冠動脈硬化症との関連,
第86回日本超音波医学会学術集会, 2013年5月. 田畑良, 山田博胤, 西尾進, 井口明子, 小幡史明, 發知淳子, 林修司, 中西嘉憲, 河南真吾, 湯浅志乃, 清水伸彦, 山口治隆, 河野光宏, 佐田政隆, 谷憲治, 坂東弘康 :
リアルタイム心エコーによる遠隔診断支援システムを運用して,
第4回日本プライマリ・ケア連合学会学術大会, 2013年5月. 田畑良, 山田博胤, 西尾進, 井口明子, 小幡史明, 發知淳子, 林修司, 中西嘉憲, 河南真吾, 湯浅志乃, 清水伸彦, 山口治隆, 河野光宏, 佐田政隆, 坂東弘康, 坂東弘康 :
リアルタイム心エコーによる遠隔診断支援システムを運用して,
第4回日本プライマリ・ケア連合学会学術大会, 2013年5月. 山田博胤 :
生活習慣病の診療にエコーを活かす,
第102回日本循環器学会中国・四国合同地方会, 2013年5月. 平田有紀奈, 西尾進, 山田博胤, 發知淳子, 坂東美佳, 林修司, 冨田紀子, 伊勢孝之, 仁木敏之, 山口浩司, 八木秀介, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 佐田政隆 :
冠動脈狭窄と関連する脂肪組織はどれか?∼超音波検査を用いた検討∼,
第102回日本循環器学会中国・四国合同地方会, 2013年5月. 西尾進, 山田博胤, 發知淳子, 平田有紀奈, 坂東美佳, 林修司, 冨田紀子, 伊勢孝之, 仁木敏之, 山口浩司, 八木秀介, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 佐田政隆 :
高血圧患者の腎末梢血管抵抗に対するイルベサルタンの効果,
第102回日本循環器学会中国・四国合同地方会, 2013年5月. 原知也, 門田宗之, 川端豊, 太田理絵, 高島啓, 坂東美佳, 坂東左知子, 松浦朋美, 上田由佳, 冨田紀子, 伊勢孝之, 仁木敏之, 山口浩司, 八木秀介, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
スピロノラクトンを中心とした薬物療法で30年間経過を観察しえたが，病勢制御困難となり手術療法を要したアルドステロン産生腺腫の一例,
第102回日本循環器学会中国・四国合同地方会, 2013年5月. 幸田舞子, 伊勢孝之, 川端豊, 門田宗之, 原知也, 太田理絵, 坂東美佳, 坂東左知子, 松浦朋美, 仁木敏之, 發知淳子, 山口浩司, 八木秀介, 岩瀬俊, 竹谷善雄, 山田博胤, 赤池雅史, 林友鴻, 長谷川拓也, 佐田政隆 :
経皮的中隔心筋焼灼術が奏功した閉塞性肥大型心筋症の1例,
第102回日本循環器学会中国・四国合同地方会, 2013年5月. 太田理絵, 山口浩司, 門田宗之, 川端豊, 原知也, 高島啓, 坂東美佳, 坂東左知子, 松浦朋美, 伊勢孝之, 仁木敏之, 上田由佳, 八木秀介, 岩瀬俊, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
治療方針に苦慮したDIC・多臓器不全合併コレステロール血晶塞栓症の一例,
第102回日本循環器学会中国・四国合同地方会, 2013年5月. 太田理絵, 山口浩司, 門田宗之, 川端豊, 原知也, 高島啓, 坂東美佳, 坂東左知子, 松浦朋美, 伊勢孝之, 仁木敏之, 上田由佳, 八木秀介, 岩瀬俊, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 坂東正章, 佐田政隆 :
治療方法選択に難渋した肺動静脈瘻合併右肺動脈上行大動脈起始症の一例,
第102回日本循環器学会中国・四国合同地方会, 2013年5月. 坂東美佳, 山田博胤, 仁木敏之, 山口浩司, 發知淳子, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 佐田政隆 :
心エコードプラ検査と心臓カテーテル検査で圧較差に乖離を認めた大動脈弁狭窄症の2例,
第102回日本循環器学会中国・四国合同地方会, 2013年5月. 羽星辰哉, 門田宗之, 發知淳子, 竹谷善雄, 神原保, 川端豊, 原知也, 高島啓, 坂東美佳, 坂東左知子, 松浦朋美, 伊勢孝之, 仁木敏之, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 北川哲也, 佐田政隆 :
プロテインC欠損に心房細動および低左心機能を合併した左室・右房内血栓の一例,
第102回日本循環器学会中国・四国合同地方会, 2013年5月. 門田宗之, 伊勢孝之, 八木秀介, 岩瀬俊, 太田理絵, 小笠原梢, 川端豊, 原知也, 坂東美佳, 坂東左知子, 松浦朋美, 發知淳子, 仁木敏之, 山口浩司, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
トルバプタンが効果を示したEisenmenger症候群に伴う高度右心不全の一例,
第102回日本循環器学会中国・四国合同地方会, 2013年5月. 高木恵理, 太田理絵, 仁木敏之, 門田宗之, 川端豊, 原知也, 高島啓, 坂東美佳, 坂東左知子, 松浦朋美, 伊勢孝之, 上田由佳, 山口浩司, 八木秀介, 岩瀬俊, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
妊娠中に静脈血栓症を発症し診断されたATⅢ欠損症合併妊娠の一例,
第102回日本循環器学会中国・四国合同地方会, 2013年5月. 山中森晶, 坂東左知子, 山口浩司, 西尾進, 太田理絵, 添木武, 松浦朋美, 門田宗之, 川端豊, 原知也, 高島啓, 坂東美佳, 伊勢孝之, 仁木敏之, 發知淳子, 上田由佳, 冨田紀子, 山口浩司, 八木秀介, 岩瀬俊, 竹谷善雄, 山田博胤, 若槻哲三, 四宮秀美, 佐田政隆 :
永久ペースメーカー植え込み後に偶発的に見つかった内頸静脈血栓の一例,
第102回日本循環器学会中国・四国合同地方会, 2013年5月. 高島啓, 島袋充生, 田端実, 植田初江, 植松悦子, 太田理絵, 門田宗之, 川端豊, 原知也, 坂東美佳, 坂東左知子, 松浦朋美, 仁木敏之, 伊勢孝之, 發知淳子, 上田由佳, 冨田紀子, 山口浩司, 福田大受, 八木秀介, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 高梨秀一郎, 佐田政隆 :
冠動脈内ステント内再狭窄4症例の病理組織学的検討,
第102回日本循環器学会中国・四国合同地方会, 2013年5月. 伊勢孝之, 岩瀬俊, 山田博胤, 川端豊, 門田宗之, 仁木敏之, 坂東美佳, 坂東左知子, 松浦朋美, 山口浩司, 八木秀介, 竹谷善雄, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
心病変の経過を観察し得たBecker型筋ジストロフィーによる心不全の1例,
第102回日本循環器学会中国・四国合同地方会, 2013年5月. 坂東左知子, 添木武, 門田宗之, 川端豊, 原知也, 高島啓, 坂東美佳, 松浦朋美, 伊勢孝之, 仁木敏之, 發知淳子, 上田由佳, 山口浩司, 八木秀介, 岩瀬俊, 竹谷善雄, 山田博胤, 若槻哲三, 石本武男, 佐田政隆 :
AVN dual pathwayにより頻拍周期が一心拍ごとに変化下Orthodromic AVRTの一例,
第102回日本循環器学会中国・四国合同地方会, 2013年5月. 松浦朋美, 添木武, 伊勢孝之, 仁木敏之, 發知淳子, 上田由佳, 冨田紀子, 山口浩司, 八木秀介, 竹谷善雄, 岩瀬俊, 山田博胤, 若槻哲三, 佐田政隆 :
通電により電動特性が変化した副伝導路の一例,
第102回日本循環器学会中国・四国合同地方会, 2013年5月. 發知淳子, 山田博胤, 西尾進, 坂東美佳, 林修司, 冨田紀子, 太田理絵, 門田宗之, 川端豊, 原知也, 高島啓, 坂東左知子, 松浦朋美, 伊勢孝之, 仁木敏之, 上田由佳, 山口浩司, 八木秀介, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 佐田政隆 :
運動誘発性肺高血圧を有する膠原病例における右室機能の検討,
第102回日本循環器学会中国・四国合同地方会, 2013年5月. 伊勢孝之, 八木秀介, 岩瀬俊, 門田宗之, 仁木敏之, 坂東美佳, 坂東左知子, 松浦朋美, 山口浩司, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
慢性心不全におけるAdaptive-Servo Ventilationの血行動態に対する効果,
第102回日本循環器学会中国・四国合同地方会, 2013年5月. 發知淳子, 山田博胤, 坂東美佳, 林修司, 冨田紀子, 平田有紀奈, 西尾進, 佐田政隆 :
大動脈弁穿孔を伴った感染症心内膜炎の1例,
第24回日本心エコー図学会学術集会, 2013年4月. 林修司, 山田博胤, 西尾進, 冨田紀子, 發知淳子, 坂東美佳, 玉井利奈, 中川摩耶, 弘田大智, 平田有紀奈, 佐田政隆 :
左房ストレイン解析における解析開始時間設定の重要性,
第24回日本心エコー図学会学術集会, 2013年4月. 坂東美佳, 山田博胤, 西尾進, 玉井利奈, 平田有紀奈, 佐田政隆 :
超音波後方散乱信号解析による頸動脈プラークの組織性状カラーマッピング法の臨床応用:急性冠症候群における検討,
第24回日本心エコー図学会学術集会, 2013年4月. 平田有紀奈, 西尾進, 友藤達陽, 真鍋泰毅, 太田理絵, 坂東美佳, 林修司, 發知淳子, 山田博胤, 佐田政隆 :
成人期に診断された右肺動脈上行大動脈起始の一例,
第24回日本心エコー図学会学術集会, 2013年4月. 西尾進, 添木武, 坂東左知子, 松浦朋美, 平田有紀奈, 坂東美佳, 發知淳子, 林修司, 冨田紀子, 山田博胤, 佐田政隆 :
心房細動例の左心耳局所炎症と左心耳経食道心エコー図指標との関連,
第24回日本心エコー図学会学術集会, 2013年4月. T Matsuura, Takeshi Soeki, S Bando, T Hara, M Kadota, Y Kawabata, Mika Bando, J Hotchi, N Tomita, Yuka Ueda, Toshiyuki Niki, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
A Renin Inhibitor Prevents Atrial Endocardial Dysfunction in Rapidly Paced Rats with Streptozotocin-induced Diabetes.,
第77回日本循環器学会学術集会, Mar. 2013. Takayuki Ise, Shusuke Yagi, Masashi Akaike, Takashi Iwase, M Kadota, R Ota, Y Kawabata, T Hara, K Ogasawara, Mika Bando, S Bando, T Matsuura, Toshiyuki Niki, J Hotchi, Koji Yamaguchi, Yoshio Taketani, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Adaptive Servo-Ventilation Improves Symptoms and Hemodynamics in Both Patients with Systolic and Diastolic Heart Failure.,
第77回日本循環器学会学術集会, Mar. 2013. Koji Yamaguchi, Takeshi Soeki, Tetsuzo Wakatsuki, Toshiyuki Niki, Yoshio Taketani, R Ota, M Kadota, Y Kawabata, T Hara, Mika Bando, S Bando, T Matsuura, Takayuki Ise, J Hotchi, Yuka Ueda, Takashi Iwase, N Tomita, Hirotsugu Yamada and Masataka Sata :
Impact of Indoxyl Sulfate, a Uremic Toxin, on Non-Culprit Coronary Plaque Composition Assessed by Integrated Backscatter Intravascular Ultrasound.,
第77回日本循環器学会学術集会, Mar. 2013. Takayuki Ise, Takashi Iwase, Shoichiro Takao, M Kadota, Mika Bando, S Bando, T Matsuura, Toshiyuki Niki, J Hotchi, Shusuke Yagi, Koji Yamaguchi, Yoshio Taketani, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike, Masafumi Harada and Masataka Sata :
Evaluation of Right Ventricular Hypertrophy by Cardiac Magnetic Resonance is Useful for Detecting Cardiac Amyloidosis.,
第77回日本循環器学会学術集会, Mar. 2013. Koji Yamaguchi, Tetsuzo Wakatsuki, Toshiyuki Niki, Yoshio Taketani, R Ota, M Kadota, Y Kawabata, T Hara, Mika Bando, S Bando, T Matsuura, Takayuki Ise, J Hotchi, Yuka Ueda, Takashi Iwase, N Tomita, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Differential Responses of Local Coagulation after Implantation of Everolimus-Eluting Stent Compared with Early-Generation Drug-Eluting Stents.,
第77回日本循環器学会学術集会, Mar. 2013. Shusuke Yagi, Takayuki Ise, Hirotsugu Yamada, S Nishio, Yuka Ueda, Takashi Iwase, Toshiyuki Niki, Koji Yamaguchi, Yoshio Taketani, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Ratio of Eicosapentaenoic Acid to Arachidonic Acid is a Predictive Factor of Albuminuria and Endothelial Function in Patients with Dyslipidemia.,
第77回日本循環器学会学術集会, Mar. 2013. Takashi Iwase, Shoichiro Takao, Masashi Akaike, Takayuki Ise, Toshiyuki Niki, Yuka Ueda, Koji Yamaguchi, Yoshio Taketani, Hirotsugu Yamada, Takeshi Soeki, Ken-ichi Aihara, Tetsuzo Wakatsuki, Yasuhiko Nishioka, Masafumi Harada and Masataka Sata :
Differentiation of Left Ventricular Systolic Dysfunction Related to Cardiac Sarcoidosis and Other Heart Diseases Using contrast-enhanced Cardiovascular Magnetic Resonance.,
第77回日本循環器学会学術集会, Mar. 2013. M Kadota, Takayuki Ise, Shusuke Yagi, Takashi Iwase, Masashi Akaike, R Ota, Y Kawabata, T Hara, K Ogasawara, Mika Bando, S Bando, T Matsuura, Toshiyuki Niki, J Hotchi, Koji Yamaguchi, Yoshio Taketani, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Effects of Tolvaptan are Predicted by Vasopressin/Aldosterone Ratio and Urine Osmolality in Patients with Chronic Heart Failure.,
第77回日本循環器学会学術集会, Mar. 2013. Toshiyuki Niki, Tetsuzo Wakatsuki, Mika Bando, Koji Yamaguchi, Yoshio Taketani, R Ota, Y Kawabata, M Kadota, T Hara, Mika Bando, Takayuki Ise, T Matsuura, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Effects of Additional Eicosapentaenoic Acid Therapy on Inflammatory Cytokines and Atherosclerotic Plaque Component Assessed by Integrated Backscatter Ultrasound Systems.,
第77回日本循環器学会学術集会, Mar. 2013. Michio Shimabukuro, C Okawa, M Higashida, H Sato, Hirotsugu Kurobe, Shoichiro Takao, Y Hirata, T Nakayama, XF Lei, JR Kim-Kaneyama, Daiju Fukuda, Hirotsugu Yamada, M Sato, Tetsuya Kitagawa and Masataka Sata :
Effects of Ezetimibe on Oxidized Cholesterol and Fatty-acid Components in Epicardial Fat and Myocardium: A Gas Chromatography-Mass Spectrometry Analysis.,
第77回日本循環器学会学術集会, Mar. 2013. 添木武, S Bando, T Matsuura, T Hara, R Ota, Y Kawabata, 坂東美佳, J Hotchi, N Tomita, 上田由佳, 仁木敏之, 伊勢孝之, 山口浩司, 八木秀介, 福田大受, 竹谷善雄, 岩瀬俊, 山田博胤, 若槻哲三, 島袋充生, 佐田政隆 :
Pentraxin 3 is a Local Inflammatory Marker in Atrial Fibrillation.,
第77回日本循環器学会学術集会, 2013年3月. Mika Bando, Hirotsugu Yamada, S Nishio, N Tomita, J Hotchi, S Hayashi, K Ogasawara, A Takashima, S Bando, Takayuki Ise, Toshiyuki Niki, T Matsuura, Yuka Ueda, Koji Yamaguchi, Shusuke Yagi, Takashi Iwase, Yoshio Taketani, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Effect of Eicosapentaenoic Acid on the Stabilization of Vulnerability in Carotid Artery Plaque: Evaluation Using iPlaque® Software.,
第77回日本循環器学会学術集会, Mar. 2013. S Bando, Daiju Fukuda, Takeshi Soeki, E Uematsu, H Sato, A Takashima, Mika Bando, T Matsuura, Toshiyuki Niki, Takayuki Ise, J Hotchi, Yuka Ueda, N Tomita, Koji Yamaguchi, Yoshio Taketani, Takashi Iwase, Shusuke Yagi, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Relationship between NLRP3 Inflammasome Activation in Adipose Tissue and Atherosclerosis.,
第77回日本循環器学会学術集会, Mar. 2013. Takeshi Soeki, Koji Yamaguchi, Toshiyuki Niki, R Ota, T Hara, M Kadota, Mika Bando, S Bando, T Matsuura, J Hotchi, N Tomita, Yuka Ueda, Takayuki Ise, Shusuke Yagi, Daiju Fukuda, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Cardiospecific microRNA Plasma Levels are Associated With Coronary Plaque Vulnerability.,
第77回日本循環器学会学術集会, Mar. 2013. E Takagi, R Ota, 仁木敏之, M Kadota, Y Kawabata, T Hara, A Takashima, 坂東美佳, S Bando, T Matsuura, 伊勢孝之, J Hotchi, 上田由佳, 山口浩司, 八木秀介, 岩瀬俊, 竹谷善雄, N Tomita, 山田博胤, 添木武, 若槻哲三, 佐田政隆, 中山聡一朗, 前田和寿, 苛原稔 :
妊娠を契機にATⅢ欠損症と診断され，血栓管理の後に出産に至った一例,
第246回徳島医学会学術集会(平成24年度冬期), 2013年2月. T Haboshi, M Kadota, J Hotchi, 竹谷善雄, T Matsuura, 伊勢孝之, 仁木敏之, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 佐田政隆, 木下肇, 神原保, 北川哲也, 古本博孝, 髙橋久弥 :
プロテインC欠損に心房細動および低左心機能を合併した左室・右房内血栓の一例,
第246回徳島医学会学術集会(平成24年度冬期), 2013年2月. S Sakamoto, M Kadota, 伊勢孝之, 岩瀬俊, S Bando, T Matsuura, 仁木敏之, J Hotchi, N Tomita, 上田由佳, 山口浩司, 八木秀介, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 佐田政隆, 赤池雅史, M Takeuchi :
再熱と寛解を繰り返す特発性心膜炎に対しイブプロフェンが有効であった1例,
第246回徳島医学会学術集会(平成24年度冬期), 2013年2月. K Ota, 仁木敏之, R Ota, Y Kawabata, M Kadota, T Hara, A Takashima, 坂東美佳, S Bando, T Matsuura, 伊勢孝之, J Hotchi, 上田由佳, 山口浩司, 八木秀介, 岩瀬俊, 竹谷善雄, N Tomita, 山田博胤, 添木武, 若槻哲三, 佐田政隆, J Shunto :
偶発的に発見された末梢動脈閉塞の二例,
第246回徳島医学会学術集会(平成24年度冬期), 2013年2月. M Koda, 佐田政隆, 伊勢孝之, Y Kawabata, 岩瀬俊, M Kadota, T Hara, R Ota, 坂東美佳, S Bando, T Matsuura, 仁木敏之, J Hotchi, N Tomita, 上田由佳, 山口浩司, 八木秀介, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, S Okazaki, 林友鴻, T Hasegawa :
難治性の閉塞性肥大型心筋症に対して経皮的中隔心筋焼灼術が著効した1例,
第246回徳島医学会学術集会(平成24年度冬期), 2013年2月. J Hotchi, 八木秀介, 岩瀬俊, 山田博胤, 佐田政隆, 近藤剛史, 福森知治, 藤田浩司, 寺澤由佳, 井上昌幸, H Sato :
原発性副甲状腺機能亢進症・高血圧・糖尿病・脂質異常症に合併した若年性多発性脳梗塞の一例,
第246回徳島医学会学術集会(平成24年度冬期), 2013年2月. R Ota, 山口浩司, M Kadota, Y Kawabata, T Hara, A Takashima, 坂東美佳, S Bando, T Matsuura, 伊勢孝之, 仁木敏之, J Hotchi, 上田由佳, 八木秀介, 岩瀬俊, 竹谷善雄, N Tomita, 山田博胤, 添木武, 若槻哲三, 佐田政隆, 髙尾正一郎, 原田雅史, M Bando :
41歳まで無症状で経過した肺動静脈瘻合併右肺動脈上行大動脈起始症の一例,
第246回徳島医学会学術集会(平成24年度冬期), 2013年2月. 坂東美佳, 山田博胤, S Nishio, R Tamai, Y Hirata, N Tomita, J Hotchi, S Hayashi, M Nakagawa, D Hirota, A Takashima, 伊勢孝之, 仁木敏之, 山口浩司, 福田大受, 八木秀介, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 佐田政隆 :
イコサペント酸エチルは頸動脈プラークの安定化に寄与する:iPlaque®を用いた検討,
第101回日本循環器学会四国地方会, 2012年12月. 上田由佳, 伊勢孝之, 岩瀬俊, K Maeda, K Nishikawa, M Kadota, T Hara, Y Kawabata, R Ota, 仁木敏之, 山口浩司, 八木秀介, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 加藤真介, 安井夏生, 佐田政隆 :
心臓リハビリテーションにおける禁煙継続効果の検討,
第101回日本循環器学会四国地方会, 2012年12月. Y Kawabata, 伊勢孝之, T Matsuura, S Bando, 岩瀬俊, K Ogasawara, 坂東美佳, 仁木敏之, J Hotchi, N Tomita, 上田由佳, 山口浩司, 八木秀介, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
高度肥満を伴った拡張型心筋症の1例,
第101回日本循環器学会四国地方会, 2012年12月. R Ota, 仁木敏之, 竹谷善雄, M Kadota, Y Kawabata, T Hara, 坂東美佳, S Bando, T Matsuura, 伊勢孝之, J Hotchi, 上田由佳, 山口浩司, 岩瀬俊, N Tomita, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
カテーテル的血栓吸引・血栓溶解療法が奏功し，心肺停止状態から救命できた院内発症急性肺血栓塞栓症の一例,
第101回日本循環器学会四国地方会, 2012年12月. M Nakagawa, 山田博胤, S Nishio, N Tomita, J Hotchi, S Hayashi, 坂東美佳, R Tamai, Y Hirata, D Hirota, S Yasuoka, K Yokokura, 仁木敏之, 伊勢孝之, 山口浩司, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 佐田政隆 :
心房細動例における拡張中期僧帽弁口血流速波高は左室充満圧を反映する,
第101回日本循環器学会四国地方会, 2012年12月. S Sakamoto, M Kadota, 伊勢孝之, 岩瀬俊, S Bando, T Matsuura, 仁木敏之, J Hotchi, N Tomita, 上田由佳, 山口浩司, 八木秀介, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
再燃と寛解を繰り返す特発性心膜炎に対しイブプロフェンが有効であった1例,
第101回日本循環器学会四国地方会, 2012年12月. N Kobayashi, T Hara, 山口浩司, K Ogasawara, 坂東美佳, S Bando, T Matsuura, J Hotchi, N Tomita, 伊勢孝之, 仁木敏之, 上田由佳, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, M Bando, 佐田政隆 :
多彩な血圧変動素因により顕著な夜間血圧を認めた一例,
第101回日本循環器学会四国地方会, 2012年12月. S Yasuoka, 山田博胤, K Yokokura, Y Hirata, D Hirota, R Tamai, M Nakagawa, S Nishio, 坂東美佳, J Hotchi, S Hayashi, N Tomita, 伊勢孝之, 仁木敏之, 山口浩司, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 佐田政隆 :
当院におけるたこつぼ型心筋症の臨床的特徴,
第101回日本循環器学会四国地方会, 2012年12月. K Yokokura, 山田博胤, S Yasuoka, Y Hirata, D Hirota, R Tamai, M Nakagawa, S Nishio, 坂東美佳, J Hotchi, S Hayashi, N Tomita, 仁木敏之, 山口浩司, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 佐田政隆 :
心エコー法を用いた平均右房圧推定法の検証,
第101回日本循環器学会四国地方会, 2012年12月. T Hara, 山口浩司, 岩瀬俊, M Kadota, K Ogasawara, 坂東美佳, S Bando, T Matsuura, J Hotchi, N Tomita, 伊勢孝之, 仁木敏之, 上田由佳, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, S Orino, 佐田政隆 :
Churg-Strauss症候群に合併した好酸球性心筋炎の一例,
第101回日本循環器学会四国地方会, 2012年12月. Mika Bando, Hirotsugu Yamada, S Nishio, R Tamai, Y Hirata, D Hirota, M Nakagawa, S Hayashi, N Tomita, J Hotchi, Toshiyuki Niki, Koji Yamaguchi, Daiju Fukuda, Shusuke Yagi, Takashi Iwase, Yoshio Taketani, Takeshi Soeki, Tetsuzo Wakatsuki, Shinji Nagahiro and Masataka Sata :
Effect of EPA of Carotid Artery Plaque Assessed by Integrated Backscatter Mapping : Development of imaging analytical software.,
第20回日本血管生物医学会学術集会, Dec. 2012. Koji Yamaguchi, Tetsuzo Wakatsuki, Toshiyuki Niki, Yoshio Taketani, H Oezuka, R Ota, Y Kawabata, T Hara, M Kadota, K Ogasawara, S Bando, T Matuura, J Hotchi, Takayuki Ise, Shusuke Yagi, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Telmisartan reduces local inflammatory response and coronary plaque vulnerability assessed by integrated backscatter intravascular ultrasound in hypertensive patients.,
第20回日本血管生物医学会学術集会, Dec. 2012. Y Yokota, S Bando, 添木武, M Kadota, T Matsuura, 山田博胤, 若槻哲三, 佐田政隆, H Yoshida, T Ishimoto :
AVN dual pathwayにより頻拍周期が1心拍ごとに変化したOrthodromic AVRTの1例,
第107回日本内科学会四国地方会, 2012年12月. M Miyauchi, T Matsuura, 上田由佳, 山口浩司, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
心臓粗動を契機として右心不全を発症し，左房還流型PLSVCとunroofed CSの合併が判明した1例,
第107回日本内科学会四国地方会, 2012年12月. M Kadota, Takayuki Ise, Takashi Iwase, Masashi Akaike, Koji Yamaguchi, Yoshio Taketani, Hirotsugu Yamada, Tetsuzo Wakatsuki, Takeshi Soeki and Masataka Sata :
Prediction of Responder and Influence for Cardio-Renal Interaction by Tolvaptan in Patients with Chronic Heart Failure.,
第16回日本心不全学会学術集会, Nov. 2012. 田畑良, 山田博胤, 西尾進, 井口明子, 小幡史明, 發知淳子, 林修司, 中西嘉憲, 河南真吾, 湯浅志乃, 清水伸彦, 山口治隆, 河野光宏, 佐田政隆, 谷憲治, 坂東弘康 :
徳島大学病院と徳島県立海部病院との心エコー遠隔診断支援システムについて,
第12回日本プライマリ・ケア連合学会四国支部学術集会, 2012年11月. Y Hirata, Y Nakagawa, S Nishio, D Hirota, R Tamai, 山田博胤, 佐田政隆 :
回腸Meckel憩室の1例,
第22回日本超音波医学会四国地方会学術集会，第11回四国地方会講習会, 2012年10月. R Tamai, 山田博胤, S Nishio, Y Hirata, D Hirota, M Nakagawa, 坂東美佳, S Hayashi, J Hotchi, 佐田政隆 :
当施設における心サルコイドーシスに心エコー所見の検討,
第22回日本超音波医学会四国地方会学術集会，第11回四国地方会講習会, 2012年10月. S Hayashi, 山田博胤, N Tomita, J Hotchi, 坂東美佳, S Nishio, M Nakagawa, D Hirota, Y Hirata, 佐田政隆 :
中心血圧と僧帽弁輪運動速波形を用いた健常者における左室・動脈連関についての検討,
第22回日本超音波医学会四国地方会学術集会，第11回四国地方会講習会, 2012年10月. J Hotchi, 山田博胤, 坂東美佳, S Hayashi, N Tomita, S Nishio, Y Hirata, D Hirota, 添木武, 佐田政隆 :
大動脈弁穿孔を伴った感染性心内膜炎の1例,
第22回日本超音波医学会四国地方会学術集会，第11回四国地方会講習会, 2012年10月. D Hirota, 山田博胤, S Nishio, Y Hirata, R Tamai, M Nakagawa, S Hayashi, J Hotchi, 佐田政隆, 齋藤憲 :
当院で経験した大動脈二尖弁の特徴,
第22回日本超音波医学会四国地方会学術集会，第11回四国地方会講習会, 2012年10月. 坂東美佳, 山田博胤, Y Hirata, D Hirota, R Tamai, M Nakagawa, S Nishio, J Hotchi, N Tomita, 佐田政隆 :
肝細胞癌化学療法中に発症した亜型たこつぼ型心筋症の1例,
第22回日本超音波医学会四国地方会学術集会，第11回四国地方会講習会, 2012年10月. M Nakagawa, S Nishio, R Tamai, D Hirota, Y Hirata, 添木武, 山田博胤, 佐田政隆 :
診断と治療効果の判定に超音波検査が有用であった上肢バージャー病の1例,
第22回日本超音波医学会四国地方会学術集会，第11回四国地方会講習会, 2012年10月. 仁木敏之, 若槻哲三, 坂東美佳, 西尾進, 小笠原梢, 坂東左知子, 伊勢孝之, 發知淳子, 山口浩司, 竹谷善雄, 岩瀬俊, 冨田紀子, 山田博胤, 添木武, 佐田政隆 :
スタチンへのEPA製剤追加による動脈硬化病変の組織性状変化に関する検討,
第60回日本心臓病学会学術集会, 2012年9月. 島袋充生, C Okawa, M Higashida, 黒部裕嗣, H Sato, 髙尾正一郎, Y Hirata, 雷小峰, S Kaneyama, T Nakayama, 福田大受, 山田博胤, M Sato, 北川哲也, 佐田政隆 :
エゼチミブ投与によるブタ心臓周囲脂肪ならびに心筋組織の酸化コレステロール，脂肪酸分画の変動:GC/MS法による検討,
第60回日本心臓病学会学術集会, 2012年9月. Y Hirata, T Hara, 山田博胤, S Nishio, D Hirota, R Tamai, M Nakagawa, 坂東美佳, J Hotchi, N Tomita, S Hayashi, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 佐田政隆 :
心膜内膿瘍を合併した収縮性心膜炎の一例,
第60回日本心臓病学会学術集会, 2012年9月. S Bando, 添木武, 伊勢孝之, 岩瀬俊, T Hara, M Kadota, 坂東美佳, K Ogasawara, J Hotchi, N Tomita, 仁木敏之, 山口浩司, 竹谷善雄, 山田博胤, 若槻哲三, 佐田政隆 :
心房周囲炎症と心囊液貯留により収縮性心膜炎の病態を呈した一例,
第60回日本心臓病学会学術集会, 2012年9月. J Hotchi, 山田博胤, S Nishio, 坂東美佳, S Hayashi, N Tomita, Y Hirata, D Hirota, R Tamai, M Nakagawa, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 佐田政隆 :
安静時に肺高血圧を呈さない膠原病例における心エコー・ドプラ法を用いた右室機能不全の評価,
第60回日本心臓病学会学術集会, 2012年9月. 山口浩司, 若槻哲三, 仁木敏之, 竹谷善雄, S Bando, 伊勢孝之, 岩瀬俊, 山田博胤, 添木武, 佐田政隆 :
シロリムス溶出ステント留置後における局所血管反応の検討-局所バイオマーカーとperi-contrast stainingの観点から-,
第60回日本心臓病学会学術集会, 2012年9月. S Hayashi, 山田博胤, N Tomita, J Hotchi, 坂東美佳, S Nishio, R Tamai, M Nakagawa, D Hirota, Y Hirata, 山口浩司, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 佐田政隆 :
僧帽弁口血流速波系が偽正常化パターンを示す左室駆出率が保持された心不全(HFPEF)と左房機能不全の鑑別,
第60回日本心臓病学会学術集会, 2012年9月. 伊勢孝之, 岩瀬俊, K Nanjo, 髙尾正一郎, R Ota, S Bando, 仁木敏之, 上田由佳, 山口浩司, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 原田雅史, 佐田政隆 :
心臓MRIを用いた左室肥大患者における右室壁厚の検討,
第60回日本心臓病学会学術集会, 2012年9月. 添木武, 山口浩司, 仁木敏之, K Ogasawara, 坂東美佳, S Bando, T Matsuura, N Tomita, 上田由佳, 伊勢孝之, 竹谷善雄, 岩瀬俊, 山田博胤, 若槻哲三, 島袋充生, 佐田政隆 :
血中micro RNAは冠動脈不安定プラークのバイオマーカーになりえるか?,
第60回日本心臓病学会学術集会, 2012年9月. S Bando, 添木武, T Matsuura, 坂東美佳, K Ogasawara, J Hotchi, N Tomita, 伊勢孝之, 仁木敏之, 山口浩司, 竹谷善雄, 岩瀬俊, 山田博胤, 若槻哲三, 島袋充生, 佐田政隆 :
NLRPインフラマソームと冠動脈硬化の関連について,
第60回日本心臓病学会学術集会, 2012年9月. 坂東美佳, 山田博胤, S Nishio, N Tomita, J Hotchi, R Tamai, M Nakagawa, D Hirota, Y Hirata, S Hayashi, K Ogasawara, 仁木敏之, 山口浩司, 添木武, 若槻哲三, 佐田政隆 :
重症大動脈弁狭窄症を呈した成人大動脈一尖弁の2例,
第60回日本心臓病学会学術集会, 2012年9月. 若槻哲三, 仁木敏之, 山口浩司, 伊勢孝之, 岩瀬俊, 竹谷善雄, 山田博胤, 添木武, 佐田政隆 :
OCTにてneovascularizationを認めた冠動脈プラークのIB-IVUSによる組織性状の評価,
第60回日本心臓病学会学術集会, 2012年9月. S Nishio, 山田博胤, M Sato, H Hiraoka, Y Hirata, D Hirota, 坂東美佳, S Hayashi, J Hotchi, N Tomita, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 佐田政隆 :
糖尿病において左房容積係数と最も相関する非侵襲的血管検査指標は何か:左房-左室-血管連関についての検討,
第60回日本心臓病学会学術集会, 2012年9月. D Hirota, 山田博胤, S Nishio, Y Hirata, R Tamai, M Nakagawa, 坂東美佳, J Hotchi, S Hayashi, N Tomita, M Sata, 齋藤憲 :
健常日本人の三尖弁輪運動速波形および三尖弁輪収縮期移動距離における加齢および性差の影響,
第60回日本心臓病学会学術集会, 2012年9月. 田畑良, 山田博胤, 西尾進, 井口明子, 小幡史明, 發知淳子, 林修司, 中西嘉憲, 河南真吾, 湯浅志乃, 清水伸彦, 山口治隆, 河野光宏, 佐田政隆, 谷憲治, 坂東弘康 :
リアルタイム心エコーによる遠隔診断支援システムについて,
第3回日本プライマリ・ケア連合学会学術大会, 2012年9月. Y Yokota, M Kadota, 伊勢孝之, 岩瀬俊, T Hara, R Ota, Y Kawabata, K Ogasawara, 坂東美佳, S Bando, T Matsuura, 仁木敏之, J Hotchi, N Tomita, 上田由佳, 山口浩司, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 佐田政隆, 赤池雅史, 江川麻理子, 三田村佳典 :
眼病変の経過中に心室中隔の肥厚および完全房室ブロックで発症した心サルコイドーシスの一例,
第245回徳島医学会学術集会(平成24年度夏期), 2012年7月. N Kawano, 仁木敏之, K Ogasawara, R Ota, M Kadota, Y Kawabata, T Hara, 伊勢孝之, T Matsuura, 上田由佳, 山口浩司, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 佐田政隆, T Yamamoto, K Kawano, 角谷明佳, K Seto, 金山博臣 :
シスプラチン，エトポシド，ブレオマイシンの三剤化学療法併用中に急性心筋梗塞を発症した二例,
第245回徳島医学会学術集会(平成24年度夏期), 2012年7月. K Matsumoto, 仁木敏之, K Ogasawara, R Ota, M Kadota, Y Kawabata, T Hara, 伊勢孝之, T Matsuura, 上田由佳, 山口浩司, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 佐田政隆, Y Sawa :
プロテインC活性低下を背景とし，オートマチック車への変更を契機に肺血栓塞栓症を発症したタクシー運転手の一例,
第245回徳島医学会学術集会(平成24年度夏期), 2012年7月. N Kobayashi, T Hara, 山口浩司, M Kadota, R Ota, Y Kawabata, K Ogasawara, 坂東美佳, S Bando, T Matsuura, J Hotchi, N Tomita, 伊勢孝之, 仁木敏之, 上田由佳, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 佐田政隆, M Bando :
著名な自立神経障害を背景とした治療抵抗性夜間高血圧症の一例,
第245回徳島医学会学術集会(平成24年度夏期), 2012年7月. 上田由佳, 岩瀬俊, 伊勢孝之, K Maeda, K Nishikawa, 坂東美佳, K Ogasawara, S Bando, 仁木敏之, J Hotchi, 山口浩司, N Tomita, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 加藤真介, 安井夏生, 佐田政隆 :
喫煙継続者における心臓リハビリテーションの効果の検討,
第18回心臓リハビリテーション学会, 2012年7月. K Maeda, 上田由佳, 伊勢孝之, 岩瀬俊, K Nishikawa, 坂東美佳, K Ogasawara, S Bando, 仁木敏之, J Hotchi, 山口浩司, N Tomita, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 加藤真介, 安井夏生, 佐田政隆 :
患者の気持ちを汲んだ患者教育の実際,
第18回心臓リハビリテーション学会, 2012年7月. A Takashima, 伊勢孝之, 上田由佳, K Maeda, K Nishikawa, K Ogasawara, 坂東美佳, N Tomita, 仁木敏之, J Hotchi, 山口浩司, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 加藤真介, 赤池雅史, 安井夏生, 佐田政隆 :
心臓リハビリテーションは酸化LDLを低下させる,
第18回心臓リハビリテーション学会, 2012年7月. S Bando, 添木武, 伊勢孝之, 岩瀬俊, 坂東美佳, K Ogasawara, J Hotchi, N Tomita, 仁木敏之, 山口浩司, 竹谷善雄, 山田博胤, 若槻哲三, 菅野幹雄, 神原保, 北川哲也, 佐田政隆 :
心房周囲炎症と心囊液貯留により収縮性心膜炎の病態を呈した一例,
第100回日本循環器学会中国・四国合同地方会, 2012年6月. A Tachibana, 伊勢孝之, 添木武, 岩瀬俊, R Ota, M Kadota, T Hara, 坂東美佳, K Ogasawara, S Bando, 仁木敏之, J Hotchi, N Tomita, 上田由佳, 山口浩司, 竹谷善雄, 山田博胤, 若槻哲三, 赤池雅史, 佐田政隆 :
CRT-Dが著効した重症拡張型心筋症の2症例,
第100回日本循環器学会中国・四国合同地方会, 2012年6月. S Nagasaka, 伊勢孝之, 岩瀬俊, R Ota, M Kadota, T Hara, 坂東美佳, K Ogasawara, S Bando, 仁木敏之, J Hotchi, N Tomita, 上田由佳, 山口浩司, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
マルチモダリティを用いて鑑別し得た冠動脈病変合併たこつぼ型心筋症の1症例,
第100回日本循環器学会中国・四国合同地方会, 2012年6月. 伊勢孝之, K Nanjo, 岩瀬俊, 髙尾正一郎, R Ota, M Kadota, T Hara, 坂東美佳, K Ogasawara, S Bando, 仁木敏之, 上田由佳, 山口浩司, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 原田雅史, 佐田政隆 :
左室肥大患者における右室壁厚の検討,
第100回日本循環器学会中国・四国合同地方会, 2012年6月. J Hotchi, S Taoka, 坂東美佳, K Ogasawara, A Takashima, H Yamasaki, S Bando, 伊勢孝之, 仁木敏之, 山口浩司, 上田由佳, N Tomita, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, Y Saijo, 佐田政隆 :
緊密な病診連携と詳細な副腎静脈サンプリングが迅速な根治術につながった原発性アルドステロン症の一例,
第100回日本循環器学会中国・四国合同地方会, 2012年6月. 伊勢孝之, 岩瀬俊, R Ota, M Kadota, T Hara, A Takashima, H Yamasaki, 坂東美佳, K Ogasawara, S Bando, 仁木敏之, J Hotchi, N Tomita, 上田由佳, 山口浩司, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
Adaptive Servo-Ventilationが心不全治療に有効であった心アミロイドーシスの2症例,
第100回日本循環器学会中国・四国合同地方会, 2012年6月. K Maeda, 上田由佳, 伊勢孝之, 岩瀬俊, K Nishikawa, 坂東美佳, K Ogasawara, S Bando, 仁木敏之, J Hotchi, 山口浩司, N Tomita, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 加藤真介, 安井夏生, 佐田政隆 :
チーム医療で取り組む重症心不全に対する心臓リハビリテーション,
第100回日本循環器学会中国・四国合同地方会, 2012年6月. S Taoka, 伊勢孝之, 岩瀬俊, R Ota, M Kadota, T Hara, K Ogasawara, 坂東美佳, S Bando, 仁木敏之, J Hotchi, N Tomita, 上田由佳, 山口浩司, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
テニスラケットによる打撲が誘引で深部静脈血栓・急性肺塞栓症を来した1症例,
第100回日本循環器学会中国・四国合同地方会, 2012年6月. K Ogasawara, 仁木敏之, 坂東美佳, S Bando, 伊勢孝之, J Hotchi, 上田由佳, 山口浩司, 岩瀬俊, 竹谷善雄, N Tomita, 山田博胤, 添木武, 若槻哲三, 島袋充生, 佐田政隆 :
永久型下大静脈フィルター血栓閉塞に対し抗凝固療法を中心とした保存的加療が有効であった2症例,
第100回日本循環器学会中国・四国合同地方会, 2012年6月. 坂東美佳, 山田博胤, K Ogasawara, 仁木敏之, N Tomita, J Hotchi, R Tamai, Y Hirata, D Hirota, S Nishio, S Bando, 伊勢孝之, 上田由佳, 山口浩司, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 佐田政隆, H Kawano, 西岡安彦 :
肺動脈血栓に対してフォンダパリヌクスが著効した静脈血栓塞栓症の一例,
第100回日本循環器学会中国・四国合同地方会, 2012年6月. S Nishio, 山田博胤, R Tamai, Y Hirata, D Hirota, M Yamao, 森一博, 佐田政隆, S Matsuoka :
子育て支援イベントにおける先天性心疾患スクリーニング:10年間のまとめ,
第100回日本循環器学会中国・四国合同地方会, 2012年6月. R Tamai, 坂東美佳, 山田博胤, S Nishio, N Tomita, J Hotchi, S Hayashi, M Nakagawa, Y Hirata, D Hirota, K Ogasawara, H Yamasaki, S Bando, 伊勢孝之, 仁木敏之, 山口浩司, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 佐田政隆 :
超音波後方散乱信号を用いたカラーマッピングシステムの脂質低下療法における臨床応用:case report,
第100回日本循環器学会中国・四国合同地方会, 2012年6月. Y Hirata, S Nishio, 山田博胤, S Hayashi, J Hotchi, N Tomita, 坂東美佳, D Hirota, R Tamai, M Nakagawa, H Hiraoka, M Sato, 佐田政隆 :
心房-心室-血管連関において左房容積係数と最も相関する血管機能指標はどれか?,
第100回日本循環器学会中国・四国合同地方会, 2012年6月. Y Oguro, 仁木敏之, K Ogasawara, 坂東美佳, S Bando, 伊勢孝之, J Hotchi, 上田由佳, 山口浩司, 竹谷善雄, 岩瀬俊, N Tomita, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
マニュアル車からオートマチック車に変更後に左下肢深部静脈血栓症を生じたタクシー運転手の一例,
第100回日本循環器学会中国・四国合同地方会, 2012年6月. 森住俊, J Hotchi, 山田博胤, 坂東美佳, H Yamasaki, K Ogasawara, K Takashima, S Bando, 伊勢孝之, 仁木敏之, 山口浩司, N Tomita, 上田由佳, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 佐田政隆 :
完全房室ブロックを合併して恒久的ペースメーカー植込みを必要としたたこつぼ型心筋症の一症例,
第100回日本循環器学会中国・四国合同地方会, 2012年6月. N Kawano, 仁木敏之, K Ogasawara, 坂東美佳, S Bando, 伊勢孝之, J Hotchi, 上田由佳, 山口浩司, 竹谷善雄, 岩瀬俊, N Tomita, 山田博胤, 添木武, 若槻哲三, T Yamamoto, K Kawano, 角谷明佳, 佐田政隆 :
シスプラチン，エトポシド，ブレオマイシンの三剤化学療法併用中に急性心筋梗塞を発症した二例,
第100回日本循環器学会中国・四国合同地方会, 2012年6月. 山口浩司, 若槻哲三, 添木武, 仁木敏之, 竹谷善雄, H Oezuka, K Ogasawara, 坂東美佳, S Bando, J Hotchi, 上田由佳, N Sakamoto, 伊勢孝之, 岩瀬俊, 山田博胤, 佐田政隆 :
テルミサルタンの冠動脈プラークに対する抗動脈硬化作用の検討,
第100回日本循環器学会中国・四国合同地方会, 2012年6月. 佐田政隆, 山田博胤, 平田陽一郎, 中村和人, 岩田洋, 松本邦夫 :
合成低分子化合物による内因性増殖因子発現誘導と循環器疾患の治療への応用,
第11回日本再生医療学会総会, 2012年6月. 弘田大智, 西尾進, 坂東美佳, 冨田紀子, 發知淳子, 林修司, 中川摩耶, 平田有紀奈, 岩瀬俊, 山田博胤, 齋藤憲, 佐田政隆 :
右室自由壁の著名な肥厚を認めた右室心筋脂肪浸潤の1例,
第37回日本超音波検査学会学術集会, 2012年6月. 玉井利奈, 西尾進, 山田博胤, 坂東美佳, 平田有紀奈, 弘田大智, 中川摩耶, 林修司, 發知淳子, 冨田紀子, 佐田政隆 :
超音波後方散乱信号を用いた頸動脈プラーク性状変化の評価,
第37回日本超音波検査学会学術集会, 2012年6月. 山田博胤 :
パネルディスカッション10 心エコーにおける技師の技術向上. 今の若者にはお膳立てが必要:環境を整えてこそ良い技師が育つ,
日本超音波医学会第85回学術集会, 2012年5月. 山田博胤 :
ワークショップ2 研修医の超音波教育のあり方∼教育カリキュラムの提案と座談会∼研修医超音波教育の現場報告(循環器領域)∼徳島大学病院の場合∼,
日本超音波医学会第85回学術集会, 2012年5月. J Hotchi, 山田博胤, M Nakagawa, S Nishio, R Tamai, Y Hirata, D Hirota, H Yamasaki, N Tomita, 佐田政隆 :
透析シャント造設後に失神を繰り返した鎖骨下動脈盗血症候群の一例,
日本超音波医学会第85回学術集会, 2012年5月. Y Hirata, S Hayashi, 山田博胤, S Nishio, N Tomita, J Hotchi, D Hirota, R Tamai, M Nakagawa, 佐田政隆 :
肺平滑筋肉腫の心筋内転移の診断，経過観察に経過観察に経過観察に傾胸壁心エコーが有用であった一例,
日本超音波医学会第85回学術集会, 2012年5月. M Nakagawa, S Nishio, 山田博胤, 中川美砂子, 武知浩和, 川上行奎, M Morimoto, 佐田政隆, 丹黒章 :
超音波検査による乳癌術前化学療法の効果予測,
日本超音波医学会第85回学術集会, 2012年5月. 坂東美佳, 山田博胤, S Nishio, R Tamai, Y Hirata, D Hirota, J Hotchi, N Tomita, 添木武, 佐田政隆 :
超音波integrated backscatterカラーマッピング法による頸動脈プラークの組織性状診断,
日本超音波医学会第85回学術集会, 2012年5月. S Hayashi, 山田博胤, N Tomita, J Hotchi, 坂東美佳, S Nishio, R Tamai, D Hirota, Y Hirata, 佐田政隆 :
僧帽弁輪運動速波刑を用いた左室駆出率が保持された心不全と心房機能不全の鑑別,
日本超音波医学会第85回学術集会, 2012年5月. D Hirota, 山田博胤, S Nishio, Y Hirata, M Nakgawa, 坂東美佳, J Hotchi, N Tomita, 佐田政隆, 齋藤憲 :
ボセンタン投与により肺動脈性肺高血圧症合併妊娠の転機が改善した一例,
日本超音波医学会第85回学術集会, 2012年5月. S Nishio, 山田博胤, M Yamao, Y Hirata, D Hirota, R Tamai, 佐田政隆, 森一博, S Matsuoka :
心エコー検査による小児心臓検診の有用性:子育て支援イベント10年間のまとめ,
日本超音波医学会第85回学術集会, 2012年5月. M Nakagawa, S Nishio, 山田博胤, 佐田政隆 :
静脈エコーでどこまで診るか?:目的別にみた検査法の工夫,
日本超音波医学会第85回学術集会, 2012年5月. 山田博胤 :
プラクティカルワークショップPW14 心エコーの計測についてもう一度考えてみよう経胸壁心エコー検査,
第23回日本心エコー図学会学術集会, 2012年4月. 西尾進, 山田博胤 :
プラクティカルワークショップPW1 心機能計測をいかに精度よく行うか 2)左室拡張能評価,
第23回日本心エコー図学会学術集会, 2012年4月. 西尾進, 山田博胤 :
シンポジウム4 左房および右心の機能の見方 1)左房機能の評価法:技師の立場から,
第23回日本心エコー図学会学術集会, 2012年4月. S Hayashi, M Sato, 山田博胤, N Tomita, J Hotchi, 坂東美佳, S Nishio, R Tamai, M Nakagawa, D Hirota, Y Hirata, 伊勢孝之, 仁木敏之, 山口浩司, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 佐田政隆 :
僧帽弁輪運動速波形指標およびAugmentation Indenxの性差と相互連関についての検討,
第23回日本心エコー図学会学術集会, 2012年4月. N Tomita, 山田博胤, S Nishio, J Hotchi, S Hayashi, 坂東美佳, M Nakagawa, R Tamai, Y Hirata, D Hirota, Hiraoka H, M Sato, 竹谷善雄, 添木武, 佐田政隆 :
大動脈弁硬化における性差の検討,
第23回日本心エコー図学会学術集会, 2012年4月. R Tamai, S Nishio, M Sato, H Hiraoka, Y Hirata, D Hirota, M Nakagawa, 坂東美佳, S Hayashi, J Hotchi, N Tomita, 山田博胤, 佐田政隆 :
2型糖尿病患者の左室拡張能に影響を及ぼす非侵襲的血管機能指標は何か?,
第23回日本心エコー図学会学術集会, 2012年4月. Y Hirata, S Nishio, K Ogasawara, 仁木敏之, 坂東美佳, N Tomita, J Hotchi, S Hayashi, M Nakagawa, R Tamai, D Hirota, 竹谷善雄, 山田博胤, 佐田政隆 :
右房内浮遊血栓から肺動脈塞栓を来したが，保存的加療が奏功した静脈血栓症の1例,
第23回日本心エコー図学会学術集会, 2012年4月. M Nakagawa, 山田博胤, S Nishio, R Tamai, N Tomita, J Hotchi, S Hayashi, 坂東美佳, Y Hirata, D Hirota, 佐田政隆 :
左室駆出率が保持された心房細動におけるL波の意義,
第23回日本心エコー図学会学術集会, 2012年4月. 山田博胤, 田畑良, S Nishio, N Tomita, J Hotchi, S Hayashi, 坂東美佳, R Tamai, M Nakagawa, 佐田政隆 :
市販のビデオ会議システムを用いた心エコー検査の遠隔診断支援システムの構築,
第23回日本心エコー図学会学術集会, 2012年4月. D Hirota, S Nishio, 坂東美佳, N Tomita, J Hotchi, S Hayashi, M Nakagawa, R Tamai, Y Hirata, 岩瀬俊, 竹谷善雄, 山田博胤, 齋藤憲, 佐田政隆 :
右室自由壁の著明な肥厚を認めた右室心筋脂肪浸潤の1例,
第23回日本心エコー図学会学術集会, 2012年4月. J Hotchi, Hirotsugu Yamada, Yoshio Taketani, S Nishio, N Tomita, S Hayashi, Mika Bando, R Tamai, D Hirota, Y Hirata, M Nakagawa and Masataka Sata :
Six-minute stress echocardiography in patients with connective tissue disease.,
第23回日本心エコー図学会学術集会, Apr. 2012. Mika Bando, Hirotsugu Yamada, S Nishio, R Tamai, N Tomita, J Hotchi, S Hayashi, M Nakagawa, Y Hirata, D Hirota, Yoshio Taketani, Takeshi Soeki and Masataka Sata :
Effect of statin therapy on carotid artery plaque assesed by integrated backscatter color mapping.,
第23回日本心エコー図学会学術集会, Apr. 2012. 弘田大智, 西尾進, 山田博胤, 遠藤桂輔, 冨田紀子, 林修司, 平田有紀奈, 玉井利奈, 中川摩耶, 佐田政隆, 齋藤憲 :
陳旧性心筋梗塞におけるV1誘導のP波と左房負荷:心エコー・ドプラ法を用いた検討,
The 76th Annual Scientific Meeting of the Japanese Circulation Society, 2012年3月. Tomita Noriko, 山田博胤, 楠瀬賢也, Nishio Susumu, Hotchi Junko, Hayashi Shuji, 坂東美佳, Bando Sachiko, 伊勢孝之, 仁木敏之, 山口浩司, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 佐田政隆 :
Clinical Efficacy of Beat-to-beat Variability of Diastolic Filling in Atrial Fibrillation.,
第76回日本循環器学会学術集会, 2012年3月. Munkbaatar Dagvasumberel, 島袋充生, Nishiuchi Takeshi, Hirata Yoichiro, 添木武, 赤池雅史, 岩瀬俊, 楠瀬賢也, 仁木敏之, 山口浩司, 小柴邦彦, 竹谷善雄, 八木秀介, Tomita Noriko, 山田博胤, 若槻哲三, 黒部裕嗣, 北川哲也, 佐田政隆 :
Gender Disparities in Association of Epicardial Adipose Tissue Volume and Coronary Atherosclerosis.,
第76回日本循環器学会学術集会, 2012年3月. Bando Sachiko, Takeshi Soeki, Ogasawara Kozue, Takashima Akira, Mika Bando, Yamazaki Hiromu, Hotchi Junko, Tomita Noriko, Takayuki Ise, Toshiyuki Niki, Koji Yamaguchi, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Relationship between NLRP3 Inflammasome and Coronary Atherosclerosis.,
第76回日本循環器学会学術集会, Mar. 2012. Hotchi Junko, Hirotsugu Yamada, Kenya Kusunose, Nishio Susumu, Mika Bando, Tomita Noriko, Hayashi Shuji, Bando Sachiko, Toshiyuki Niki, Takayuki Ise, Koji Yamaguchi, Takashi Iwase, Yoshio Taketani, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Effect of Irbesartan on Left Ventricular Myocardial Function in Patients with Hypertension: Assessment by Two-dimensional Speckle Tracking Echocardiography.,
第76回日本循環器学会学術集会, Mar. 2012. Koji Yamaguchi, Tetsuzo Wakatsuki, Toshiyuki Niki, Yoshio Taketani, Bando Sachiko, Hotchi Junko, Tomita Noriko, Takayuki Ise, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Angiographic Peri-stent Contrast Staining Leading to Local Persistent Hypercoagulability up to Five Years after Sirolimus-eluting Stent Implantation:Comparison with Bare-Metal Stent.,
第76回日本循環器学会学術集会, Mar. 2012. Kimura Sahika, 上田由佳, 伊勢孝之, 岩瀬俊, Takashima Akira, Yamazaki Hiromu, Ogasawara Kozue, Bando Sachiko, Hayashi Shuji, Takeuchi Hidekazu, 仁木敏之, 楠瀬賢也, 山口浩司, Tomita Noriko, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
Cardiac Rehabilitation decreases Urinary Albumin Excretion in Patients with Cardiovascular Disease.,
第76回日本循環器学会学術集会, 2012年3月. Takashima Akira, Takayuki Ise, Takashi Iwase, Yuka Ueda, Masashi Akaike, Yamazaki Hiromu, Mika Bando, Ogasawara Kozue, Bando Sachiko, Tomita Noriko, Takeuchi Hidekazu, Toshiyuki Niki, Hotchi Junko, Koji Yamaguchi, Yoshio Taketani, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Effect of Cardiac Rehabilitation on Level of Oxidized LDL.,
第76回日本循環器学会学術集会, Mar. 2012. Hirotsugu Yamada, Tomita Noriko, Hayashi Shuji, Hotchi Junko, Nishio Susumu, Tamai Rina, Toshiyuki Niki, Koji Yamaguchi, Takashi Iwase, Yoshio Taketani, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Prognostic Value of Preload Stress Echocardiographyin Patients with Mild Heart Failure.,
第76回日本循環器学会学術集会, Mar. 2012. 添木武, 仁木敏之, 山口浩司, 坂東左知子, 上田由佳, 冨田紀子, 伊勢孝之, 楠瀬賢也, 竹谷善雄, 岩瀬俊, 山田博胤, 若槻哲三, 赤池雅史, 島袋充生, 佐田政隆 :
Inflammatory Biomarkers as Predictors of Vulnerable Coronary Plaques.,
第76回日本循環器学会学術集会，Symposium 3, 2012年3月. 山田博胤, 西尾進, 坂東美佳, 發知淳子, 林修司, 冨田紀子, 伊勢孝之, 仁木敏之, 山口浩司, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 佐田政隆 :
Carotid Ultrasound Imaging to Evaluate Atherosclerotic Diseases.,
第76回日本循環器学会学術集会，KSC-JCS Joint Symposium-2, 2012年3月. 立花綾香, 上田由佳, 伊勢孝之, 高島啓, 山崎宙, 小笠原梢, 坂東左知子, 仁木敏之, 發知淳子, 冨田紀子, 山口浩司, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 佐田政隆, 赤池雅史, 廣野明 :
CRT-Dが著効した重症慢性心不全の1例,
第244回徳島医学会学術集会 (平成23年度冬期), 2012年2月. 田岡志保, 上田由佳, 伊勢孝之, 高島啓, 山崎宙, 小笠原梢, 坂東左知子, 仁木敏之, 發知淳子, 冨田紀子, 山口浩司, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 佐田政隆, 赤池雅史, 井上洋行 :
テニスラケットによる外傷が誘因で深部静脈血栓・急性肺塞栓症を来した一症例,
第244回徳島医学会学術集会 (平成23年度冬期), 2012年2月. 森住俊, 發知淳子, 山田博胤, 山崎宙, 小笠原梢, 高島啓, 坂東美佳, 坂東左知子, 竹内秀和, 伊勢孝之, 仁木敏之, 山口浩司, 冨田紀子, 上田由佳, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 佐田政隆, 久保克之, 佐々木克哉, 富田芳雄 :
たこつぼ型心筋症に完全房室ブロックを合併した一症例,
第244回徳島医学会学術集会 (平成23年度冬期), 2012年2月. 坂東美佳, 山田博胤, 冨田紀子, 發知淳子, 小笠原梢, 高島啓, 山崎宙, 坂東左知子, 伊勢孝之, 仁木敏之, 上田由佳, 山口浩司, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 赤池雅史, 佐田政隆, 西尾進, 林修司, 中川摩耶, 玉井利奈, 平田有紀奈, 弘田大智 :
脂質低下療法による頸動脈プラーク安定化の評価:超音波integrated backscatterを用いたカラーマッピングシステムの臨床応用,
第244回徳島医学会学術集会 (平成23年度冬期), 2012年2月. 山口浩司, 若槻哲三, 添木武, 仁木敏之, 竹谷善雄, 小笠原梢, 坂東美佳, 坂東左知子, 發知淳子, 上田由佳, 冨田紀子, 竹内秀和, 伊勢孝之, 岩瀬俊, 山田博胤, 佐田政隆, 麻植塚浩康 :
テルミサルタンの冠動脈プラークに対する抗動脈硬化作用の検討,
第244回徳島医学会学術集会 (平成23年度冬期), 2012年2月. 仁木敏之, 小笠原梢, 坂東美佳, 坂東左知子, 竹内秀和, 伊勢孝之, 發知淳子, 上田由佳, 山口浩司, 岩瀬俊, 竹谷善雄, 冨田紀子, 山田博胤, 添木武, 若槻哲三, 佐田政隆, 中瀧恵実子, 西村匡司, 上山祐二 :
低体温療法が著効し社会復帰をなし得たBrugada症候群の一例,
第244回徳島医学会学術集会 (平成23年度冬期), 2012年2月. 太田理絵, 若槻哲三, 岩瀬俊, 髙尾正一郎, 山田博胤, 赤池雅史, 坂東左知子, 仁木敏之, 能勢隼人, 冨田紀子, 山口浩司, 竹谷善雄, 添木武, 西岡安彦, 原田雅史, 佐田政隆 :
肺，皮膚病変診断4年後に心病変が顕在化したサルコイドーシスの1例,
第22回日本心血管画像動態学会, 2012年1月. 仁木敏之, 若槻哲三, 山口浩司, 竹谷善雄, 岩瀬俊, 麻植塚浩康, 西尾進, 小笠原梢, 坂東美佳, 坂東左知子, 伊勢孝之, 冨田紀子, 山田博胤, 添木武, 佐田政隆 :
冠動脈プラークに対するスタチンへのEPA製剤add on 効果の検討-IB-IVUSおよびIB-頸動脈エコーの観点から-,
第22回日本心血管画像動態学会, 2012年1月. 松浦彩, 稲垣辰憲, 齋藤憲, 佐藤光代, 山田博胤, 吉川陽子, 矢野勇人 :
心サルコイドーシスに於けるfragmented QRS(fQRS)の出現頻度とその臨床的意義,
徳島県臨床検査技師会誌, 30, 2011年12月. 前田香代子, 上田由佳, 伊勢孝之, 岩瀬俊, 西川幸治, 高島啓, 小笠原梢, 山崎宙, 坂東左知子, 仁木敏之, 發知淳子, 山口浩司, 冨田紀子, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 髙田信二郎, 安井夏生, 佐田政隆 :
大学病院での心臓リハビリテーション立ち上げの問題点,
第99回日本循環器学会四国地方会, 2011年12月. 坂東美佳, 林修司, 山田博胤, 冨田紀子, 發知淳子, 西尾進, 玉井利奈, 平田有紀奈, 弘田大智, 小笠原梢, 高島啓, 山崎宙, 坂東左知子, 伊勢孝之, 仁木敏之, 山口浩司, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 佐田政隆 :
平滑筋肉腫の心筋内転移の診断，経過観察に経胸壁心エコー法が有用であった一例,
第99回日本循環器学会四国地方会, 2011年12月. 高島啓, 山口浩司, 原知也, 山崎宙, 小笠原梢, 坂東左知子, 發知淳子, 冨田紀子, 竹内秀和, 仁木敏之, 伊勢孝之, 上田由佳, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 花岡潤, 島田光生, 佐田政隆 :
真性多血症患者に発症した心原生脾梗塞の1例,
第99回日本循環器学会四国地方会, 2011年12月. 田根なつ紀, 山口浩司, 竹谷善雄, 高島啓, 山崎宙, 小笠原梢, 坂東左知子, 仁木敏之, 伊勢孝之, 發知淳子, 岩瀬俊, 冨田紀子, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
重症下肢虚血病変に対して経皮的下肢動脈形成術が奏功し，予定されていた下肢切断手術を回避できた一症例,
第99回日本循環器学会四国地方会, 2011年12月. 高橋直希, 仁木敏之, 高島啓, 山崎宙, 小笠原梢, 坂東左知子, 伊勢孝之, 發知淳子, 山口浩司, 岩瀬俊, 竹谷善雄, 冨田紀子, 山田博胤, 添木武, 若槻哲三, 佐田政隆, 中瀧恵実子, 西村匡司, 上山祐二 :
低体温療法が著効し社会復帰をなし得たBrugada症候群の一例,
第99回日本循環器学会四国地方会, 2011年12月. 藤岡啓介, 山崎宙, 伊勢孝之, 楠瀬賢也, 木村白陽花, 高島啓, 小笠原梢, 坂東左知子, 發知淳子, 冨田紀子, 竹内秀和, 上田由佳, 仁木敏之, 山口浩司, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
ULPの発生から拡大，消失までを経時的に観察し得たacute aortic syndromeの一例,
第99回日本循環器学会四国地方会, 2011年12月. 坂東左知子, 山田博胤, 添木武, 木内誠, 北畑洋, 山口浩司, 竹谷善雄, 岩瀬俊, 若槻哲三, 佐田政隆 :
全身麻酔により顕在性Brugada型心電図の1例,
第105回日本内科学会四国地方会, 2011年11月. 坂東左知子, 添木武, 伊勢孝之, 竹谷善雄, 岩瀬俊, 山田博胤, 若槻哲三, 木村建彦, 西内健, 佐田政隆 :
CRT-Dによって僧帽弁閉鎖不全症が劇的に改善した突発性拡張型心筋症の1例,
第105回日本内科学会四国地方会, 2011年11月. 山田博胤 :
左室壁運動異常を診る∼ヒトの眼vs機械の目∼,
第44回中国四国医学検査学会, 2011年11月. 岩瀬俊, 髙尾正一郎, 赤池雅史, 能勢隼人, 伊勢孝之, 小笠原梢, 山崎宙, 髙島啓, 坂東左知子, 仁木敏之, 楠瀬賢也, 發知淳子, 冨田紀子, 上田由佳, 山口浩司, 山田博胤, 添木武, 若槻哲三, 西岡安彦, 原田雅史, 佐田政隆 :
心臓MRIによるサルコイドーシス心病変検出の有用性,
第31回日本サルコイドーシス/肉芽腫性疾患学会総会, 2011年10月. 山田博胤 :
揺さぶってはじめて分かる心機能∼さまざまな負荷心エコーの臨床応用∼,
第21回日本超音波医学会四国地方会第10回四国地方会講習会, 2011年10月. 安岡紗哉香, 楠瀬賢也, 山田博胤, 發知淳子, 冨田紀子, 林修司, 西尾進, 中川摩耶, 平田有紀奈, 佐田政隆 :
ボセンタン投与により肺動脈性肺高血圧症合併妊娠の転機が改善した一例,
第21回日本超音波医学会四国地方学術集会, 2011年10月. 林修司, 山田博胤, 西尾進, 玉井利奈, 中川摩耶, 弘田大智, 平田有紀奈, 岩瀬俊, 添木武, 佐田政隆 :
多発性肺平衡筋肉腫の心筋内転移の診断，経過観察に経胸壁心エコーが有用であった一例,
第21回日本超音波医学会四国地方学術集会, 2011年10月. 發知淳子, 山田博胤, 楠瀬賢也, 西尾進, 冨田紀子, 林修司, 弘田大智, 玉井利奈, 添木武, 佐田政隆 :
保存的加療により潰瘍様突出像が消退した大動脈壁内血腫の一例,
第21回日本超音波医学会四国地方学術集会, 2011年10月. 玉井利奈, 山田博胤, 西尾進, 冨田紀子, 林修司, 發知淳子, 平田有紀奈, 弘田大智, 添木武, 佐田政隆 :
左心不全に合併した肺高血圧症における三尖弁輪運動速波形の特徴,
第21回日本超音波医学会四国地方学術集会, 2011年10月. 冨田紀子, 山田博胤, 西尾進, 林修司, 發知淳子, 中川摩耶, 平田有紀奈, 弘田大智, 添木武, 佐田政隆 :
S字状中隔心の心エコー・ドプラ所見についての検討,
第21回日本超音波医学会四国地方会学術集会, 2011年10月. Takayuki Ise, Takashi Iwase, Kumiko Kagawa, Toshiyuki Niki, Kenya Kusunose, 冨田紀子, Yuka Ueda, Koji Yamaguchi, Yoshio Taketani, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Masahiro Abe, Masashi Akaike and Masataka Sata :
Successful Autologous Peripheral Blood Stem Cell Transplantation for Primary Cardiac Amyloidosis Patients with Heart Failure : three cases report.,
第15回日本心不全学会学術集会, Oct. 2011. 冨田紀子, 楠瀬賢也, 山田博胤, 西尾進, 林修司, 玉井利奈, 坂東左知子, 久岡白陽花, 上田由佳, 仁木敏之, 山口浩司, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 佐田政隆 :
心房細動における僧帽弁口血流速拡張早期波の心拍変動性の臨床的意義,
第59回日本心臓病学会学術集会, 2011年9月. 林修司, 山田博胤, 楠瀬賢也, 冨田紀子, 西尾進, 玉井利奈, 三木淳子, 坂東左知子, 仁木敏之, 山口浩司, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 佐田政隆 :
三尖弁輪運動速波形による肥大型心筋症と高血圧性心疾患の鑑別,
第59回日本心臓病学会学術集会, 2011年9月. 岩瀬俊, 髙尾正一郎, 赤池雅史, 能勢隼人, 久岡白陽花, 伊勢孝之, 仁木敏之, 楠瀬賢也, 山口浩司, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 西岡安彦, 原田雅史, 佐田政隆 :
サルコイドーシス心病変検出における心臓MRI検査の有用性,
第59回日本心臓病学会学術集会, 2011年9月. 坂東左知子, 添木武, 仁木敏之, 久岡白陽花, 竹内秀和, 冨田紀子, 楠瀬賢也, 上田由佳, 山口浩司, 竹谷善雄, 岩瀬俊, 山田博胤, 若槻哲三, 赤池雅史, 寒川賢治, 佐田政隆 :
グレリンによる自律神経およびConnexin43発現調節を介した抗不整脈作用の検討,
第59回日本心臓病学会学術集会, 2011年9月. 山田博胤, 楠瀬賢也, 西尾進, 冨田紀子, 玉井利奈, 清水拓, 林修司, 坂東左知子, 仁木敏之, 山口浩司, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 佐田政隆 :
膠原病における潜在性肺動脈性高血圧症の検出:運動負荷心エコー法の有用性,
第59回日本心臓病学会学術集会, 2011年9月. 西尾進, 山田博胤, 楠瀬賢也, 冨田紀子, 林修司, 玉井利奈, 三木淳子, 仁木敏之, 山口浩司, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 佐田政隆 :
冠動脈硬化症を最も反映する非侵襲的血管検査法についての検討,
第59回日本心臓病学会学術集会, 2011年9月. 玉井利奈, 山田博胤, 楠瀬賢也, 西尾進, 林修司, 冨田紀子, 坂東左知子, 仁木敏之, 山口浩司, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 佐田政隆 :
左心不全に合併した肺高血圧症における三尖弁輪運動速波形の特徴:HFPEFとHFREFの差異,
第59回日本心臓病学会学術集会, 2011年9月. 山口浩司, 若槻哲三, 添木武, 仁木敏之, 竹谷善雄, 麻植塚浩康, 坂東左知子, 上田由佳, 冨田紀子, 竹内秀和, 楠瀬賢也, 岩瀬俊, 山田博胤, 佐田政隆 :
冠動脈プラークに対するテルミサルタンの多面的効果の検討-Integrated backscatter IVUS観察と炎症性サイトカインによる観点から-,
第59回日本心臓病学会学術集会, 2011年9月. 添木武, 坂東左知子, 仁木敏之, 久岡白陽花, 竹内秀和, 楠瀬賢也, 上田由佳, 冨田紀子, 山口浩司, 竹谷善雄, 岩瀬俊, 山田博胤, 若槻哲三, 赤池雅史, 佐田政隆 :
心房細動における局所炎症反応に関する検討,
第59回日本心臓病学会学術集会, 2011年9月. 若槻哲三, 仁木敏之, 楠瀬賢也, 山口浩司, 竹谷善雄, 岩瀬俊, 麻植塚浩康, 西尾進, 坂東左知子, 冨田紀子, 竹内秀和, 山田博胤, 添木武, 佐田政隆 :
冠動脈プラークに対するスタチンへのEPA製剤add on効果の検討 -Integrated backscatter IVUSおよび局所Biomaker観察の観点から-,
第59回日本心臓病学会学術集会, 2011年9月. 高木恵理, 高島啓, 山口浩司, 竹谷善雄, 坂東左知子, 冨田紀子, 竹内秀和, 仁木敏之, 楠瀬賢也, 上田由佳, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆, 森本篤志, 橋本一郎, 中西秀樹, 和田美智子, 石本武男, 田蒔正治 :
重症下肢虚血病変に対して経皮的下肢動脈血管形成術が奏功し，予定されていた下肢切手術を回避できた一症例,
第243回徳島医学会学術集会, 2011年7月. 原知也, 岩瀬俊, 高島啓, 山崎宙, 小笠原梢, 坂東左知子, 伊勢孝之, 仁木敏之, 楠瀬賢也, 上田由佳, 冨田紀子, 山口浩司, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
心サルコイドーシス診断の手引きにおける各種診断モダリティーの検討,
第243回徳島医学会学術集会, 2011年7月. 高島啓, 添木武, 山口浩司, 竹谷善雄, 坂東左知子, 林修司, 久岡白陽花, 冨田紀子, 竹内秀和, 仁木敏之, 楠瀬賢也, 上田由佳, 岩瀬俊, 山田博胤, 若槻哲三, 赤池雅史, 佐田政隆 :
埋め込み型デバイスにより胸郭内インピーダンスの増悪と改善が観察できた拡張相肥大型心筋症の一例,
第243回徳島医学会学術集会, 2011年7月. 西川幸治, 上田由佳, 久岡白陽花, 前田香代子, 岩瀬俊, 坂東左知子, 林修司, 竹内秀和, 仁木敏之, 楠瀬賢也, 山口浩司, 冨田紀子, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 髙田信二郎, 安井夏生, 佐田政隆 :
当院心臓リハビリテーション参加者の運動能力について,
第17回日本心臓リハビリテーション学会学術集会, 2011年7月. 前田香代子, 上田由佳, 久岡白陽花, 岩瀬俊, 西川幸治, 坂東左知子, 林修司, 竹内秀和, 仁木敏之, 楠瀬賢也, 山口浩司, 冨田紀子, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 髙田信二郎, 安井夏生, 佐田政隆 :
大学病院での心臓リハビリテーション立ち上げに携わって,
第17回日本心臓リハビリテーション学会学術集会, 2011年7月. 久岡白陽花, 上田由佳, 岩瀬俊, 前田香代子, 西川幸治, 坂東左知子, 林修司, 竹内秀和, 仁木敏之, 楠瀬賢也, 山口浩司, 冨田紀子, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 髙田信二郎, 安井夏生, 佐田政隆 :
尿中アルブミン排泄量に及ぼす心臓リハビリテーションの効果,
第17回日本心臓リハビリテーション学会学術集会, 2011年7月. 玉井利奈, 西尾進, 山田博胤, 遠藤桂輔, 栗坂彩美, 三木淳子, 楠瀬賢也, 林修司, 冨田紀子, 佐田政隆 :
下肢血管エコー検査における深部静脈血栓とD-dimer値,
第84回日本超音波医学会学術集会, 2011年5月. 楠瀬賢也, 山田博胤, 西尾進, 冨田紀子, 林修司, 玉井利奈, 添木武, 赤池雅史, 佐田政隆 :
TE-e'は左室拡張末期圧を反映する―下肢腸圧および硝酸薬負荷を用いた検討―,
第84回日本超音波医学会学術集会, 2011年5月. 林修司, 山田博胤, 楠瀬賢也, 冨田紀子, 多田津陽子, 西尾進, 玉井利奈, 岩瀬俊, 添木武, 佐田政隆 :
体位変換により右室内圧較差が変化をきたす右室二腔症の一例,
第84回日本超音波医学会学術集会, 2011年5月. 西尾進, 山田博胤, 楠瀬賢也, 玉井利奈, 佐藤光代, 冨田紀子, 林修司, 添木武, 赤池雅史, 佐田政隆 :
冠動脈硬化症を最も反映する非侵襲的血管検査指標は何か?,
第84回日本超音波医学会学術集会, 2011年5月. 山田博胤 :
フレッシャーズセミナー心エコーーで学ぶ聴診，心エコーで学ぶ心音,
第98回日本循環器学会中国四国合同地方会, 2011年5月. 竹内秀和, Tetsuzo Wakatsuki, 阪本紀子, Toshiyuki Niki, Kenya Kusunose, Koji Yamaguchi, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
BNP relates to FT3 negatively in cardiac patients with normal FT3, which might be mediated by HDAC3.,
第98回日本循環器学会中国・四国合同地方会, May 2011. 清水拓, 楠瀬賢也, 山田博胤, 西尾進, 冨田紀子, 林修司, 玉井利奈, 河野裕美, 平岡葉月, 佐藤光代, 竹谷善雄, 添木武, 佐田政隆 :
運動負荷心エコー法を用いた膠原病例における潜在性肺動脈性肺高血圧症の検出,
第98回日本循環器学会中国・四国合同地方会, 2011年5月. Munkhbaatar Dagvasumberel, Junji Ueno, Shoichiro Takao, 西内健, 平田陽一郎, 坂東左知子, 久岡白陽花, 林修司, 冨田紀子, 竹内秀和, Yuka Ueda, Toshiyuki Niki, Kenya Kusunose, Koji Yamaguchi, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Tetsuya Kitagawa and Masataka Sata :
Increased epicardial adipose tissue and coronary atherosclerosis.,
第98回日本循環器学会中国・四国合同地方会, May 2011. 山中森晶, 山田博胤, 楠瀬賢也, 冨田紀子, 林修司, 仁木敏之, 山口浩司, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 佐田政隆, 西尾進, 玉井利奈, 三木淳子 :
ストロークケアユニット(SCU)に救急搬送された心原性脳塞栓症例の特徴,
第98回日本循環器学会中国・四国合同地方会, 2011年5月. 玉井利奈, 西尾進, 山田博胤, 楠瀬賢也, 冨田紀子, 林修司, 三木淳子, 坂東左知子, 仁木敏之, 山口浩司, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 佐田政隆 :
下肢静脈エコー検査におけるD-dimer値の意義,
第98回日本循環器学会中国・四国合同地方会, 2011年5月. 西尾進, 山田博胤, 玉井利奈, 平田陽一郎, 楠瀬賢也, 冨田紀子, 林修司, 三木淳子, 坂東左知子, 仁木敏之, 山口浩司, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 佐田政隆 :
頸動脈エコーによるプラークの超音波性状カラーイメージの試み,
第98回日本循環器学会中国・四国合同地方会, 2011年5月. 前田香代子, 上田由佳, 久岡白陽花, 岩瀬俊, 西川幸治, 坂東左知子, 林修司, 竹内秀和, 仁木敏之, 楠瀬賢也, 山口浩司, 冨田紀子, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 髙田信二郎, 安井夏生, 佐田政隆 :
通院型心臓リハビリテーションの継続における開始3カ月目の重要性,
第98回日本循環器学会中国・四国合同地方会, 2011年5月. 西川幸治, 上田由佳, 久岡白陽花, 前田香代子, 岩瀬俊, 坂東左知子, 林修司, 竹内秀和, 仁木敏之, 楠瀬賢也, 山口浩司, 冨田紀子, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 髙田信二郎, 安井夏生, 佐田政隆 :
心臓リハビリによる運動能力改善を阻害する因子の検討,
第98回日本循環器学会中国・四国合同地方会, 2011年5月. 佐藤光代, 山田博胤, 平岡葉月, 西尾進, 玉井利奈, 楠瀬賢也, 冨田紀子, 林修司, 三木淳子, 佐田政隆 :
動脈硬化指標としてのbaPWVとCAVIの比較,
第98回日本循環器学会中国・四国合同地方会, 2011年5月. 太田理絵, 岩瀬俊, 久岡白陽花, 山田博胤, 西岡安彦, 髙尾正一郎, 坂東左知子, 能勢隼人, 楠瀬賢也, 仁木敏之, 冨田紀子, 上田由佳, 山口浩司, 竹谷善雄, 添木武, 若槻哲三, 赤池雅史, 曽根三郎, 佐田政隆 :
心室固有調律が心病変診断のきっかけとなったサルコイドーシスの1例,
第98回日本循環器学会中国・四国合同地方会, 2011年5月. 原知也, 楠瀬賢也, 山田博胤, 西尾進, 冨田紀子, 林修司, 玉井利奈, 坂東左知子, 久岡白陽花, 仁木敏之, 上田由佳, 山口浩司, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
心サルコイドーシスにおける左室形態異常の多様性,
第98回日本循環器学会中国・四国合同地方会, 2011年5月. 小笠原梢, 仁木敏之, 添木武, 坂東左知子, 久岡白陽花, 竹内秀和, 楠瀬賢也, 山口浩司, 竹谷善雄, 岩瀬俊, 冨田紀子, 山田博胤, 若槻哲三, 佐田政隆 :
様々な要因によりtorsade de pointesを来した一例,
第98回日本循環器学会中国・四国合同地方会, 2011年5月. 久岡白陽花, 上田由佳, 岩瀬俊, 前田香代子, 西川幸治, 坂東左知子, 林修司, 竹内秀和, 仁木敏之, 楠瀬賢也, 山口浩司, 冨田紀子, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 髙田信二郎, 安井夏生, 佐田政隆 :
尿中アルブミン排出量に及ぼす通院心臓リハビリテーションの効果,
第98回日本循環器学会中国・四国合同地方会, 2011年5月. 高島啓, 山口浩司, 添木武, 坂東左知子, 林修司, 久岡白陽花, 冨田紀子, 竹内秀和, 仁木敏之, 楠瀬賢也, 竹谷善雄, 岩瀬俊, 山田博胤, 若槻哲三, 佐田政隆 :
埋め込み型デバイスにより胸郭内インピーダンスの憎悪と改善が観察できた拡張肥大型心筋症の一例,
第98回日本循環器学会中国・四国合同地方会, 2011年5月. 冨田紀子, 山田博胤, 西尾進, 楠瀬賢也, 林修司, 玉井利奈, 遠藤桂輔, 平岡葉月, 佐藤光代, 坂東左知子, 久岡白陽花, 竹内秀和, 上田由佳, 仁木敏之, 山口浩司, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 佐田政隆 :
超高齢者における大動脈弁硬化の進行に関与する因子についての検討,
第98回日本循環器学会中国・四国合同地方会, 2011年5月. 林修司, 山田博胤, 楠瀬賢也, 冨田紀子, 西尾進, 玉井利奈, 三木淳子, 坂東左知子, 久岡白陽花, 仁木敏之, 山口浩司, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 佐田政隆 :
S字状中隔によるdynamic obstructionが胸痛の原因と考えられた高齢者の一例,
第98回日本循環器学会中国・四国合同地方会, 2011年5月. 坂東左知子, 添木武, 久岡白陽花, 冨田紀子, 竹内秀和, 仁木敏之, 楠瀬賢也, 山口浩司, 竹谷善雄, 岩瀬俊, 山田博胤, 若槻哲三, 赤池雅史, 佐田政隆 :
房室結節三重伝道路の存在が示唆された房室結節リエントリー性頻拍の1例,
第98回日本循環器学会中国・四国合同地方会, 2011年5月. 高島啓, 山口浩司, 坂東左知子, 林修司, 久岡白陽花, 冨田紀子, 竹内秀和, 仁木敏之, 楠瀬賢也, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 吉田守美子, 松本俊夫, 佐田政隆 :
甲状腺機能亢進症と腰痛が発症の誘因と考えられた難治性冠攣縮性狭心症の1例,
第98回日本循環器学会中国・四国合同地方会, 2011年5月. 外磯千智, 岩瀬俊, 楠瀬賢也, 山田博胤, 添木武, 若槻哲三, 佐田政隆, 赤池雅史, 髙尾正一郎, 原田雅史 :
心臓MRI検査で左室に広範なガドリニウム異常集積を認めたNoonan syndromeの1例,
第104回日本内科学会四国地方会, 2011年5月. 冨田紀子, 山田博胤, 楠瀬賢也, 西尾進, 林修司, 玉井利奈, 遠藤桂輔, 河野裕美, 平岡葉月, 佐藤光代, 竹谷善雄, 添木武, 佐田政隆 :
高齢者における大動脈弁硬化の進行に関与する因子についての検討,
第22回日本心エコー図学会学術集会, 2011年4月. 林修司, 山田博胤, 楠瀬賢也, 西尾進, 玉井利奈, 冨田紀子, 遠藤桂輔, 河野裕美, 平岡葉月, 佐藤光代, 竹谷善雄, 添木武, 佐田政隆 :
徐脈を呈する高齢者の左室弛緩能についての検討:僧帽弁口血流速パターンをどう解釈するか,
第22回日本心エコー図学会学術集会, 2011年4月. 清水拓, 楠瀬賢也, 山田博胤, 西尾進, 冨田紀子, 林修司, 玉井利奈, 遠藤桂輔, 河野裕美, 平岡葉月, 佐藤光代, 竹谷善雄, 添木武, 佐田政隆 :
運動負荷心エコー法を用いた膠原病例における潜在性肺動脈性肺高血圧症の検出,
第22回日本心エコー図学会学術集会, 2011年4月. 竹谷善雄, 山田博胤, 楠瀬賢也, 西尾進, 冨田紀子, 林修司, 玉井利奈, 遠藤桂輔, 河野裕美, 平岡葉月, 佐藤光代, 添木武, 佐田政隆 :
三次元心エコー法により術前診断ができたペースメーカーリードの弁尖穿通による重症三尖弁逆流の一例,
第22回日本心エコー図学会学術集会, 2011年4月. 玉井利奈, 山田博胤, 西尾進, 楠瀬賢也, 冨田紀子, 林修司, 遠藤桂輔, 河野裕美, 平岡葉月, 佐藤光代, 竹谷善雄, 添木武, 佐田政隆 :
心エコー検査で診断された肺高血圧症連続387例の基礎疾患と三尖弁輪運動速波形指標,
第22回日本心エコー図学会学術集会, 2011年4月. 西尾進, 山田博胤, 玉井利奈, 林修司, 遠藤桂輔, 清水拓, 高島弘光, 山中森晶, 不動祐司, 酒井芳紀, 佐田政隆 :
モノクロタリン誘発性イヌ肺高血圧モデルにおけるMモード法およびスペックストラッキング法を用いた右室収縮能の検討,
第22回日本心エコー図学会学術集会, 2011年4月. 高島啓, 山田博胤, 楠瀬賢也, 西尾進, 冨田紀子, 林修司, 遠藤桂輔, 玉井利奈, 河野裕美, 平岡葉月, 佐藤光代, 竹谷善雄, 添木武, 佐田政隆 :
リアルタイム3次元経食道心エコーガイド下に経皮的僧帽弁交連切開術を行った僧帽弁狭窄症の1例,
第22回日本心エコー図学会学術集会, 2011年4月. 山田博胤, 遠藤桂輔, 西尾進, 楠瀬賢也, 冨田紀子, 林修司, 玉井利奈, 河野裕美, 平岡葉月, 佐藤光代, 竹谷善雄, 添木武, 佐田政隆 :
陳旧性心筋梗塞症におけるV1誘導のP terminal forceの臨床的意義: 心エコー・ドプラ法を用いた検討,
第22回日本心エコー図学会学術集会, 2011年4月. 添木武, 仁木敏之, 山口浩司, S. Bando, 上田由佳, N. Tomita, 伊勢孝之, 楠瀬賢也, 竹谷善雄, 岩瀬俊, 山田博胤, 若槻哲三, 赤池雅史, 島袋充生, 佐田政隆 :
Inflammatory Biomarkers as Predictors of Vulnerable Coronary Plaques.,
第76回日本循環器学会学術集会，Symposium 3, 2011年3月. S. Nishio, Hirotsugu Yamada, Kenya Kusunose, N. Tomita, S. Hayashi, K. Endo, R. Tamai, J. Miki, S. Bando, Toshiyuki Niki, Koji Yamaguchi, Takashi Iwase, Yoshio Taketani, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Which Noninvasive Vascular Index is the Best Predictor of the Severity of Coronary Atherosclerosis?,
第75回日本循環器学会総会・学術集会, Mar. 2011. S. Hayashi, Hirotsugu Yamada, S. Nishio, N. Tomita, Kenya Kusunose, K. Endo, R. Tamai, S. Bando, S. Hisaoka, H. Takeuchi, Toshiyuki Niki, Koji Yamaguchi, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Tricuspid Annular Motion Velocity in Left Ventricular Hypertrophy: Comparison between Hypertensive Heart Disease and Hypertrophic Cardiomyopathy.,
第75回日本循環器学会総会・学術集会, Mar. 2011. Toshiyuki Niki, Takeshi Soeki, S. Bando, Kenya Kusunose, S. Hisaoka, S. Hayashi, Yuka Ueda, S. Tomita, H. Takeuchi, Takashi Iwase, Yoshio Taketani, Hirotsugu Yamada, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Role of Circulating High-Mobility Group Box-1 (HMGB1) in Patients with Coronary Artery Disease.,
第75回日本循環器学会総会・学術集会, Mar. 2011. Kenya Kusunose, Hirotsugu Yamada, N. Tomita, S. Nishio, S. Bando, S. Hisaoka, S. Hayashi, Toshiyuki Niki, Koji Yamaguchi, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Clinical Efficacy of Beat-to-beat Variability of Diastolic Filling in Atrial Fibrillation.,
第75回日本循環器学会総会・学術集会, Mar. 2011. Takashi Iwase, Shoichiro Takao, Masashi Akaike, S. Bando, S. Hisaoka, Toshiyuki Niki, Kenya Kusunose, N Tomita, Y. Hirata, Yuka Ueda, Koji Yamaguchi, Yoshio Taketani, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Ken-ichi Aihara, M. Harada and Masataka Sata :
Diagnostic Utility of Cardiac Magnetic Resonance for Prediction of Cardiac Events in Patients with Hypertrophic Cardiomyopathy.,
第75回日本循環器学会総会・学術集会, Mar. 2011. Hirotsugu Yamada, Masataka Sata and T. Oki :
Diagnosis of Heart Failure with Preserved Ejection Fraction by Doppler Echocardiography.,
第75回日本循環器学会総会・学術集会, Mar. 2011. Tetsuzo Wakatsuki, Koji Yamaguchi, Yoshio Taketani, Toshiyuki Niki, Kenya Kusunose, N. Tomita, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Analysis of Tissue Characteristics of In-Stent Restenotic Lesion 5-Years after Coronary Stenting with Drug-Eluting Stent Using Integrated Backscatter Intravascular Ultrasound.,
第75回日本循環器学会総会・学術集会, Mar. 2011. 高柳友貴, 仁木敏之, 坂東左知子, 久岡白陽花, 林修司, 上田由佳, 冨田紀子, 竹内秀和, 楠瀬賢也, 山口浩司, 岩瀬俊, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆, 中山泰介, 北川哲也, 村野栄一 :
ペースメーカーリードの弁尖穿通による重症三尖弁逆流症の一例,
第242回徳島医学会学術集会，平成22年度冬期, 2011年2月. 坂東美佳, 仁木敏之, 楠瀬賢也, 山口浩司, 竹内秀和, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆, 能勢隼人, 大塚秀樹, 原田雅史 :
拡張型心筋症として診断・加療されていた心サルコイドーシスの一例,
第242回徳島医学会学術集会，平成22年度冬期, 2011年2月. 末広英也, 楠瀬賢也, 山田博胤, 西尾進, 冨田紀子, 坂東左知子, 久岡白陽花, 林修司, 仁木敏之, 山口浩司, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆, 能勢隼人, 大塚秀樹, 髙尾正一郎, 原田雅史 :
心サルコイドーシスにおける左室形態異常の多様性,
第242回徳島医学会学術集会，平成22年度冬期, 2011年2月. 太田理絵, 冨田紀子, 楠瀬賢也, 坂東左知子, 久岡白陽花, 林修司, 竹内秀和, 仁木敏之, 山口浩司, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆, 木村建彦, 西内健, 黒部裕嗣, 北川哲也 :
出産後の甲状腺機能亢進症が発見の契機となったLeft Main Coronary Trunk Compression Syndromeの一例,
第242回徳島医学会学術集会，平成22年度冬期, 2011年2月. 髙島啓, 楠瀬賢也, 山田博胤, 西尾進, 冨田紀子, 坂東左知子, 久岡白陽花, 林修司, 仁木敏之, 山口浩司, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆, 竹崎彰夫, 多田浩也, 曽根三郎 :
コントラスト心エコー法で診断できたHepatopulmonary Syndromeの1例,
第242回徳島医学会学術集会，平成22年度冬期, 2011年2月. 清水拓, 楠瀬賢也, 山田博胤, 西尾進, 玉井利奈, 遠藤桂輔, 佐藤光代, 河野裕美, 赤池雅史, 佐田政隆 :
運動負荷心エコー法を用いた膠原病例における潜在性肺動脈性高血圧症の検出,
第242回徳島医学会学術集会，平成22年度冬期, 2011年2月. 山田博胤, 玉井利奈, 清水拓, 西尾進, 岩瀬俊, 楠瀬賢也, 遠藤桂輔, 赤池雅史, 佐田政隆, 八木秀介 :
膠原病と肺高血圧,
肺高血圧症とエンドセリン学術講演会, 2010年12月. 小笠原梢, 楠瀬賢也, 山田博胤, 西尾進, 冨田紀子, 仁木敏之, 山口浩司, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 竹崎彰夫, 多田浩也, 曽根三郎, 佐田政隆 :
コントラスト心エコー法で診断できたHepatopulmonary Syndromeの1例,
第97回日本循環器学会四国地方会, 2010年12月. 坂東左知子, 添木武, 仁木敏之, 久岡白陽花, 平田陽一郎, 冨田紀子, 竹内秀和, 楠瀬賢也, 山口浩司, 竹谷善雄, 岩瀬俊, 山田博胤, 岩瀬俊, 赤池雅史, 佐田政隆 :
二種類の上室性頻拍出が認められた例,
第97回日本循環器学会四国地方会, 2010年12月. 高柳友貴, 仁木敏之, 山田博胤, 楠瀬賢也, 山口浩司, 岩瀬俊, 冨田紀子, 竹谷善雄, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
ペースメーカーリードの弁尖穿通による重症三尖弁逆流症の1例,
第97回日本循環器学会四国地方会, 2010年12月. 竹内秀和, 平田陽一郎, 冨田紀子, Kenya Kusunose, Yoshio Taketani, Hirotsugu Yamada, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
HDL-C interacts to EPA positively,which might mean HDL-C regulates EPA via SREBP.,
第97回日本循環器学会四国地方会, Dec. 2010. 坂東美佳, 仁木敏之, 楠瀬賢也, 山口浩司, 竹内秀和, 竹谷義雄, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
心サルコイドーシスの1例,
第97回日本循環器学会四国地方会, 2010年12月. 末広英也, 楠瀬賢也, 山口浩司, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
心室中隔肥厚を認めた心サルコイドーシスの1例,
第103回日本内科学会四国地方会, 2010年11月. 山崎宙, 山口浩司, 楠瀬賢也, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
趾間部のマダニ咬傷後に足趾血行不良から壊死に陥った1例,
第103回日本内科学会四国地方会, 2010年11月. 山田博胤 :
教育講演麻酔科医に知って欲しい経胸壁心エコー法による心機能評価,
日本臨床麻酔科学会第30回大会, 2010年11月. 山田博胤 :
TEEセミナー1 TEEの基礎左室と右室の機能評価,
日本臨床麻酔科学会第30回大会, 2010年11月. 玉井利奈, 遠藤桂輔, 山田博胤, 佐田政隆, 西尾進, 河野裕美, 平岡葉月, 佐藤光代 :
下肢陽圧負荷心エコー検査の臨床応用∼肥大型心筋症の2例∼,
第43回中国四国医学検査学会, 2010年11月. 遠藤桂輔, 斉藤憲, 山田博胤, 楠瀬賢也, 冨田紀子, 西尾進, 林修司, 添木武, 赤池雅史, 佐田政隆 :
高度僧帽弁輪石灰化による多発性脳梗塞の1例,
第20回日本超音波医学会四国地方会学術集会, 2010年10月. 太田理恵, 冨田紀子, 楠瀬賢也, 山田博胤, 西尾進, 遠藤桂輔, 佐藤光代, 添木武, 赤池雅史, 佐田政隆 :
産後の甲状腺機能亢進が診断の契機となったLeft Main Coronary Trunk Compression Syndromeの一例,
第20回日本超音波医学会四国地方会学術集会, 2010年10月. 河野裕美, 山田博胤, 佐藤光代, 西尾進, 冨田紀子, 遠藤桂輔, 楠瀬賢也, 添木武, 赤池雅史, 佐田政隆 :
Intramural hematoma(IMH)を呈したStanford B型大動脈解離の二例,
第20回日本超音波医学会四国地方会学術集会, 2010年10月. 玉井利奈, 山田博胤, 西尾進, 遠藤桂輔, 仁木敏之, 楠瀬賢也, 冨田紀子, 添木武, 赤池雅史, 佐田政隆 :
三次元心エコー法により術前診断ができたペースメーカーリードの弁尖穿通による重症三尖弁逆流の一例,
第20回日本超音波医学会四国地方会学術集会, 2010年10月. 林修司, 山田博胤, 楠瀬賢也, 西尾進, 冨田紀子, 遠藤桂輔, 玉井利奈, 添木武, 赤池雅史, 佐田政隆 :
徐脈の高齢者において僧帽弁口血流波形がE>Aを呈するメカニズムについての検討,
第20回日本超音波医学会四国地方会学術集会, 2010年10月. 清水拓, 山田博胤, 楠瀬賢也, 西尾進, 玉井利奈, 遠藤桂輔, 佐藤光代, 河野裕美, 赤池雅史, 佐田政隆 :
運動負荷心エコー法を用いた膠原病例における潜在性肺動脈性肺高血圧症の検出,
第20回日本超音波医学会四国地方会学術集会, 2010年10月. 末広英也, 楠瀬賢也, 山田博胤, 西尾進, 佐藤光代, 冨田紀子, 玉井利奈, 遠藤桂輔, 赤池雅史, 佐田政隆 :
心室中隔肥厚を認めた心サルコイドーシスの1例,
第20回日本超音波医学会四国地方会学術集会, 2010年10月. 山田博胤, 三代裕一郎, 楠瀬賢也, 仁木敏之, 林修司, 山口浩司, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
高齢者および壮年者における高圧利尿薬インダパミドの少量追加投与の有効性と安全性-連日投与と隔日投与の比較-,
第33回日本高血圧学会総会, 2010年10月. 山口浩司, 若槻哲三, 坂東左知子, 久岡白陽花, 仁木敏之, 楠瀬賢也, 冨田紀子, 竹内秀和, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 赤池雅史, 佐田政隆, 麻植塚浩康 :
冠動脈プラークに対する薬剤多面的効果の検討-Integrated backscatter IVUS観察による観点から-,
第58回日本心臓病学会学術集会, 2010年9月. 若槻哲三, 仁木敏之, 楠瀬賢也, 山口浩司, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 赤池雅史, 佐田政隆 :
薬剤溶出ステントによる冠動脈内皮機能障害の経年変化に関する検討,
第58回日本心臓病学会学術集会, 2010年9月. 冨田紀子, 山田博胤, 楠瀬賢也, 西尾進, 林修司, 遠藤桂輔, 河野裕美, 平岡葉月, 佐藤光代, 山口浩司, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
S字状中隔を呈する例の心エコー・ドプラ所見についての検討,
第58回日本心臓病学会学術集会, 2010年9月. 坂東左知子, 添木武, 仁木敏之, 久岡白陽花, 竹内秀和, 平田陽一郎, 冨田紀子, 楠瀬賢也, 山口浩司, 竹谷善雄, 岩瀬俊, 山田博胤, 若槻哲三, 赤池雅史, 佐田政隆 :
脳性ナトリウム利尿ペプチド(BNP)と癌との関係について,
第58回日本心臓病学会学術集会, 2010年9月. 添木武, 仁木敏之, 坂東左知子, 久岡白陽花, 竹内秀和, 楠瀬賢也, 冨田紀子, 平田陽一郎, 山口浩司, 竹谷善雄, 岩瀬俊, 山田博胤, 若槻哲三, 赤池雅史, 寒川賢治, 佐田政隆 :
グレリンの心臓自律神経への作用と心血管系における意義,
第58回日本心臓病学会学術集会, 2010年9月. 林修司, 山田博胤, 中田拓史, 楠瀬賢也, 西尾進, 冨田紀子, 玉井利奈, 遠藤桂輔, 河野裕美, 平岡葉月, 佐藤光代, 竹谷善雄, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
僧帽弁口血流速波形用いた左室拡張能評価の限界:E>Aパターンを呈する高齢者での検討,
第58回日本心臓病学会学術集会, 2010年9月. 遠藤桂輔, 山田博胤, 楠瀬賢也, 西尾進, 冨田紀子, 三木淳子, 林修司, 玉井利奈, 河野裕美, 平岡葉月, 佐藤光代, 添木武, 若槻哲三, 赤池雅史, 齋藤憲, 佐田政隆 :
EPA/AA比は冠動脈疾患の重症度に相関する:徳島大学病院循環器内科データベースを用いた検討,
第58回日本心臓病学会学術集会, 2010年9月. 仁木敏之, 若槻哲三, 山口浩司, 楠瀬賢也, 竹谷善雄, 岩瀬俊, 冨田紀子, 山田博胤, 添木武, 赤池雅史, 佐田政隆 :
薬剤溶出ステント植え込み慢性期における冠動脈局所凝固異常に対するスタチンの効果,
第58回日本心臓病学会学術集会, 2010年9月. 冨田紀子, 楠瀬賢也, 玉井利奈, 遠藤桂輔, 西尾進, 三木淳子, 林修司, 仁木敏之, 山口浩司, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
出産後の甲状腺機能亢進症が発見の契機となったLeft Main Coronary Trunk Compression Syndromeの一例,
第58回日本心臓病学会学術集会, 2010年9月. 楠瀬賢也, 山田博胤, 西尾進, 冨田紀子, 玉井利奈, 遠藤桂輔, 三木淳子, 坂東左知子, 仁木敏之, 山口浩司, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
拡張型心筋症の左室内同期不全に対する前負荷増大の影響:3次元心エコー法を用いた検討,
第58回日本心臓病学会学術集会, 2010年9月. 玉井利奈, 山田博胤, 楠瀬賢也, 西尾進, 冨田紀子, 三木淳子, 林修司, 遠藤桂輔, 河野裕美, 平岡葉月, 佐藤光代, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
下肢陽圧負荷心エコー法が臨床的に有用であった肥大型心筋症の2例,
第58回日本心臓病学会学術集会, 2010年9月. 西尾進, 山田博胤, 楠瀬賢也, 冨田紀子, 林修司, 玉井利奈, 遠藤桂輔, 三木淳子, 竹崎彰夫, 多田浩也, 添木武, 若槻哲三, 赤池雅史, 曽根三郎, 佐田政隆 :
コントラスト心エコー法で診断できたHepatopulmonary Syndoromeの1例,
第58回日本心臓病学会学術集会, 2010年9月. 門田宗之, 楠瀬賢也, 竹谷善雄, 坂東左知子, 久岡白陽花, 仁木敏之, 冨田紀子, 竹内秀和, 山口浩司, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
繰り返す心不全と維持透析導入から離脱しえた腎動脈狭窄症の一例,
第241回徳島医学会学術集会(平成22年度夏期), 2010年8月. 阿部容子, 添木武, 仁木敏之, 楠瀬賢也, 平田陽一郎, 冨田紀子, 山口浩司, 竹谷善雄, 岩瀬俊, 山田博胤, 若槻哲三, 佐田政隆, 坂東正章, 清水渉 :
KCNH2遺伝子にダブル異変を認めた先天性QT延長症候群の兄弟例,
第241回徳島医学会学術集会(平成22年度夏期), 2010年8月. 山崎宙, 山口浩司, 坂東左知子, 久岡白陽花, 仁木敏之, 楠瀬賢也, 冨田紀子, 竹内秀和, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 佐田政隆, 福永豊, 中西秀樹 :
趾間部のマダニ咬傷後に足趾血行不良から壊死に陥った1例,
第241回徳島医学会学術集会(平成22年度夏期), 2010年8月. 太田理絵, 仁木敏之, 岩瀬俊, 坂東左知子, 久岡白陽花, 楠瀬賢也, 上田由佳, 冨田紀子, 山口浩司, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 佐田政隆, 原田雅史, 髙尾正一郎 :
軽微な臨床経過にもかかわらず心臓MRI検査にて異常所見を認めた急性心筋炎の1例,
第241回徳島医学会学術集会(平成22年度夏期), 2010年7月. 小笠原梢, 仁木敏之, 楠瀬賢也, 山口浩司, 小柴邦彦, 冨田紀子, 竹谷善雄, 岩瀬俊, 山田博胤, 若槻哲三, 添木武, 赤池雅史, 佐田政隆, 北川哲也 :
IgA腎症ともやもや病を合併した若年発症の感染性心内膜炎の一例,
第96回日本循環器学会中国・四国合同地方会, 2010年6月. 岩河早保, 楠瀬賢也, 岩瀬俊, 仁木敏之, 山口浩司, 小柴邦彦, 冨田紀子, 竹谷善雄, 山田博胤, 若槻哲三, 赤池雅史, 佐田政隆, 橋詰俊二, 木村建彦, 西内健 :
出産後left main compression syndromeによる狭心症を発症した心内膜床欠損(不完全型)の1例,
第96回日本循環器学会中国・四国合同地方会, 2010年6月. 坂東美佳, 山口浩司, 岩瀬俊, 楠瀬賢也, 仁木敏之, 冨田紀子, 小柴邦彦, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
高度拡張不全による心不全症状の再燃を認めた心尖部肥大型心筋症の1例,
第96回日本循環器学会中国・四国合同地方会, 2010年6月. 阿部容子, 添木武, 仁木敏之, 楠瀬賢也, 平田陽一郎, 冨田紀子, 山口浩司, 小柴邦彦, 竹谷善雄, 岩瀬俊, 山田博胤, 若槻哲三, 赤池雅史, 坂東正章, 清水渉, 佐田政隆 :
KCNH2遺伝子にダブル変異を認めた先天性QT延長症候群の1例,
第96回日本循環器学会中国・四国合同地方会, 2010年6月. 楠瀬賢也, 竹谷善雄, 西尾進, 仁木敏之, 山口浩司, 小柴邦彦, 岩瀬俊, 冨田紀子, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
右腎癌摘出後に心不全を繰り返した腎動脈狭窄症の一例,
第96回日本循環器学会中国・四国合同地方会, 2010年6月. 仁木敏之, 添木武, 楠瀬賢也, 山口浩司, 小柴邦彦, 竹谷善雄, 岩瀬俊, 冨田紀子, 山田博胤, 若槻哲三, 赤池雅史, 佐田政隆 :
心電図異常が乏しいBrugada症候群の1例,
第96回日本循環器学会中国・四国合同地方会, 2010年6月. 鹿草宏, 仁木敏之, 楠瀬賢也, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
急性大動脈解離の1例,
日本内科学会第102回四国地方会, 2010年5月. 原知也, 仁木敏之, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆, 関啓 :
大動脈二尖弁における感染性心内膜炎に合併した大動脈弁輪周囲膿瘍の1例,
日本内科学会第102回四国地方会, 2010年5月. 山田博胤 :
ソノグラファーを育てるために医師は何をすべきか．What should Physicians do for Promoting Sonographers?,
日本超音波医学会第83回学術集会, 2010年5月. 楠瀬賢也, 山田博胤, 西尾進, 冨田紀子, 林修司, 河野裕美, 佐藤光代, 添木武, 赤池雅史, 佐田政隆 :
虚血の診断に有用な指標は何か?,
日本超音波医学会第83回学術集会, 2010年5月. 楠瀬賢也, 山田博胤, 西尾進, 冨田紀子, 林修司, 河野裕美, 佐藤光代, 添木武, 赤池雅史, 佐田政隆 :
卵円孔開存の診断におけるコントラストリアルタイム3次元経食道心エコー法の有用性,
日本超音波医学会第83回学術集会, 2010年5月. 山田博胤, 楠瀬賢也, 西尾進, 佐田政隆, 大木崇 :
肺静脈血流速波形の意義,
日本超音波医学会第83回学術集会, 2010年5月. 西尾進, 松浦哲也, 鈴江直人, 山田博胤 :
上腕骨小頭離断性骨軟骨炎における小頭骨端部への栄養血管血流の臨床的意義,
日本超音波医学会第83回学術集会, 2010年5月. 高島弘光, 山田博胤, 楠瀬賢也, 西尾進, 冨田紀子, 三村千尋, 佐藤光代, 添木武, 赤池雅史, 佐田政隆 :
大動脈弁硬化における頸動脈の動脈硬化所見の検討,
日本超音波医学会第83回学術集会, 2010年5月. 山田博胤, 楠瀬賢也, 西尾進, 河野裕美, 佐藤光代, 冨田紀子, 林修司, 添木武, 赤池雅史, 佐田政隆 :
下肢陽圧負荷時の僧帽弁口血流速波形の反応性を用いた軽症心不全患者の予後予測:''前負荷ストレス心エコー法''の臨床応用,
日本超音波医学会第83回学術集会, 2010年5月. 佐藤光代, 平岡葉月, 山本良, 永峰康孝, 庄野和子, 土井俊夫, 山田博胤, 齋藤憲 :
特異な心電図所見を呈した肥大型心筋症の親子例,
第59回日本医学検査学会, 2010年5月. 竹谷善雄, 若槻哲三, 山田博胤, 山口浩司, 西尾進, 楠瀬賢也, 冨田紀子, 林修司, 仁木敏之, 小柴邦彦, 岩瀬俊, 添木武, 赤池雅史, 佐田政隆 :
スタチンによる冠動脈プラーク性状の短期変化についてのIB-IVUSを用いた検討,
第21回日本心エコー図学会学術集会, 2010年5月. 林修司, 山田博胤, 西尾進, 楠瀬賢也, 冨田紀子, 河野裕美, 平岡葉月, 佐藤光代, 三木淳子, 仁木敏之, 山口浩司, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
3次元経食道心エコー(3D-TEE)法にて経過が観察できた巨大左心耳血栓の1例,
第21回日本心エコー図学会学術集会, 2010年5月. 遠藤桂輔, 山田博胤, 西尾進, 冨田紀子, 楠瀬賢也, 林修司, 佐藤光代, 平岡葉月, 河野裕美, 三木淳子, 竹谷善雄, 添木武, 若槻哲三, 赤池雅史, 佐田政隆, 齋藤憲 :
リアルタイム3次元経食道エコー法により観察しえた孤立性僧帽弁クレフトの1例,
第21回日本心エコー図学会学術集会, 2010年5月. 楠瀬賢也, 山田博胤, 西尾進, 岩瀬俊, 冨田紀子, 林修司, 三木淳子, 遠藤桂輔, 河野裕美, 平岡葉月, 佐藤光代, 仁木敏之, 山口浩司, 小柴邦彦, 竹谷善雄, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
心房のみの心アミロイドーシスにおける心筋局所ストレインとMRIガドリニウム遅延造影所見の比較,
第21回日本心エコー図学会学術集会, 2010年5月. 西尾進, 山田博胤, 楠瀬賢也, 冨田紀子, 林修司, 遠藤桂輔, 河野裕美, 平岡葉月, 佐藤光代, 三木淳子, 竹谷善雄, 添木武, 赤池雅史, 佐田政隆 :
コントラスト心エコー法で診断した肝肺症候群の1例,
第21回日本心エコー図学会学術集会, 2010年5月. 西尾進, 山田博胤, 楠瀬賢也, 冨田紀子, 林修司, 三木淳子, 遠藤桂輔, 河野裕美, 平岡葉月, 佐藤光代, 仁木敏之, 山口浩司, 小柴邦彦, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
心房のみの心病変を認めた多発性筋炎の一例,
第21回日本心エコー図学会学術集会, 2010年5月. 中田拓史, 山田博胤, 楠瀬賢也, 西尾進, 冨田紀子, 林修司, 遠藤桂輔, 河野裕美, 平岡葉月, 佐藤光代, 三木淳子, 竹谷善雄, 添木武, 赤池雅史, 佐田政隆 :
僧帽弁口血流速波形がE>Aパターンを呈する高齢者の内訳,
第21回日本心エコー図学会学術集会, 2010年5月. 山田博胤 :
心房細動と塞栓症-何時，どのような治療を始めるか?-,
第240回徳島医学会学術集会公開シンポジウム, 2010年2月. 山田博胤 :
教育講演:左室拡張不全を心エコー・ドプラ法で診る,
第19回日本超音波医学会四国地方会, 2009年12月. 楠瀬賢也, 山田博胤, 西尾進, 冨田紀子, 遠藤桂輔, 河野裕美, 佐藤光代, 添木武, 赤池雅史, 佐田政隆, 平岡葉月 :
心エコー・ドプラ指標により前負荷軽減に対する心反応性は予測できるか,
日本超音波医学会四国地方会, 2009年12月. 西尾進, 山田博胤, 遠藤桂輔, 佐藤光代, 平岡葉月, 河野裕美, 三木淳子, 楠瀬賢也, 冨田紀子, 多田津陽子, 添木武, 佐田政隆 :
卵円孔にトラップされた下肢静脈遊離血栓の1例∼3D経食道心エコー法による観察∼,
日本超音波医学会四国地方会, 2009年12月. 遠藤桂輔, 齋藤憲, 山田博胤, 楠瀬賢也, 冨田紀子, 多田津陽子, 添木武, 佐田政隆, 西尾進, 佐藤光代, 平岡葉月, 河野裕美, 三木淳子 :
心エコー図検査で偶然発見された乳頭状線維弾性腫の2例,
日本超音波医学会四国地方会, 2009年12月. 溝口佳緒里, 浦山みどり, 齋藤憲, 佐藤光代, 山田博胤 :
心サルコイドーシスの心電図的特徴―サルコイドーシスとの比較―,
第33回徳島県医学検査学会, 2009年12月. 山田博胤 :
僧帽弁逸脱に伴う僧帽弁閉鎖不全の1例．形成可能か?,
第8回阪神弁膜症シンポジウム, 2009年10月. 吉田守美子, 粟飯原賢一, 伊勢孝之, 住友由佳, 松本俊夫, 八木秀介, 岩瀬俊, 赤池雅史, 山田博胤, 佐田政隆, 西尾進 :
副腎アンドロゲンDHEASの抗動脈硬化作用における性差の検討,
第32回日本高血圧学会学術集会, 2009年10月. 吉田守美子, 粟飯原賢一, 伊勢孝之, 上田由佳, 八木秀介, 岩瀬俊, 山田博胤, 赤池雅史, 佐田政隆, 松本俊夫 :
副腎アンドロゲンDHEASの抗動脈硬化作用における性差の検討,
第32回日本高血圧学会総会, 2009年10月. 山口浩司, 若槻哲三, 仁木敏之, 楠瀬賢也, 小柴邦彦, 八木秀介, 竹谷善雄, 岩瀬俊, 冨田紀子, 山田博胤, 添木武, 赤池雅史, 佐田政隆 :
シロリムス溶出性ステント留置後における局所凝固反応とステント長の関連性,
第57回日本心臓病学会学術集会, 2009年9月. 岩瀬俊, 髙尾正一郎, 赤池雅史, 足立克仁, 八木秀介, 仁木敏之, 楠瀬賢也, 山口浩司, 小柴邦彦, 山田博胤, 添木武, 若槻哲三, 原田雅史, 西谷弘, 佐田政隆 :
Duchenne型筋ジストロフィー女性キャリアにおける心病変早期検出の試み-心臓MRIによる検討-,
第57回日本心臓病学会学術集会, 2009年9月. 西尾進, 楠瀬賢也, 山田博胤, 冨田紀子, 遠藤桂輔, 千葉ちひろ, 平岡葉月, 佐藤光代, 鈴木麗子, 粟飯原賢一, 藤中雄一, 佐田政隆 :
糖尿病の動脈硬化指標:%FMDを用いた検討,
第57回日本心臓病学会学術集会, 2009年9月. 冨田紀子, 楠瀬賢也, 山田博胤, 西尾進, 遠藤桂輔, 仁木敏之, 山口浩司, 小柴邦彦, 八木秀介, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
大動脈弁硬化の進行に関連する因子,
第57回日本心臓病学会学術集会, 2009年9月. 小柴邦彦, 添木武, 仁木敏之, 楠瀬賢也, 平田陽一郎, 山口浩司, 冨田紀子, 八木秀介, 岩瀬俊, 山田博胤, 若槻哲三, 赤池雅史, 佐田政隆 :
Th1/Th2バランスの改善を介したPravastatinの実験的自己免疫性心筋炎抑制効果,
第57回日本心臓病学会学術集会, 2009年9月. 若槻哲三, 山口浩司, 仁木敏之, 楠瀬賢也, 小柴邦彦, 八木秀介, 岩瀬俊, 竹谷善雄, 冨田紀子, 山田博胤, 添木武, 赤池雅史, 佐田政隆 :
薬剤溶出ステント植え込み後慢性期の冠動脈局所炎症と凝固異常遷延の関連性,
第57回日本心臓病学会学術集会, 2009年9月. 楠瀬賢也, 山田博胤, 西尾進, 冨田紀子, 遠藤桂輔, 仁木敏之, 山口浩司, 小柴邦彦, 八木秀介, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
心房細動におけるE/e'の計測法:dual Doppler法を用いた検討,
第57回日本心臓病学会学術集会, 2009年9月. 西尾進, 山田博胤, 楠瀬賢也, 冨田紀子, 佐藤光代, 平岡葉月, 仁木敏之, 山口浩司, 小柴邦彦, 八木秀介, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
ASD，PSに合併した右室転移性腫瘤の1例,
第57回日本心臓病学会学術集会, 2009年9月. 添木武, 仁木敏之, 小柴邦彦, 楠瀬賢也, 平田陽一郎, 山口浩司, 八木秀介, 冨田紀子, 竹谷善雄, 岩瀬俊, 山田博胤, 若槻哲三, 赤池雅史, 佐田政隆 :
血漿pentraxin3 (PTX3)濃度は冠動脈不安定プラークの指標となり得るか?,
第57回日本心臓病学会学術集会, 2009年9月. 楠瀬賢也, 山田博胤, 西尾進, 冨田紀子, 遠藤桂輔, 仁木敏之, 山口浩司, 小柴邦彦, 八木秀介, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
僧帽弁口血流と僧帽弁輪運動の開始時間の差は左室拡張末期圧を反映する:下肢陽圧負荷を用いた検討,
第57回日本心臓病学会学術集会, 2009年9月. 近藤可菜, 八木秀介, 赤池雅史, 岩瀬俊, 楠瀬賢也, 仁木敏之, 山口浩司, 小柴邦彦, 竹谷善雄, 冨田紀子, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
重症心不全患者に対するAdaptive-servo ventilator療法の効果,
第239回徳島医学会学術集会, 2009年8月. 平田陽一郎, 仁木敏之, 山口浩司, 楠瀬賢也, 小柴邦彦, 八木秀介, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆, 黒部裕嗣, 神原保, 筑後文雄, 北川哲也, 堀貴樹 :
冠動脈周囲脂肪組織におけるマクロファージ浸潤の動脈硬化病変形成に与える影響,
第239回徳島医学会学術集会, 2009年8月. 山田博胤, 西尾進 :
超音波で診る心臓の仕組みと病気,
ビハーラ講演会, 2009年8月. 山田博胤 :
経食道心エコー法,
第11会日本生理検査学会地方会, 2009年7月. 楠瀬賢也, 山田博胤, 冨田紀子, 佐田政隆, 岸史, 土井俊夫, 西尾進, 遠藤桂輔, 平岡葉月, 佐藤光代, 三木淳子 :
ファブリー病の2家系,
第105回UCG談話会, 2009年7月. 西尾進, 山田博胤, 楠瀬賢也, 佐藤光代, 平岡葉月, 冨田紀子, 阿部美保, 佐田政隆 :
両心房粘液腫の1例,
第34回日本超音波検査学会, 2009年6月. 平岡葉月, 山田博胤, 西尾進, 佐藤光代, 楠瀬賢也, 冨田紀子, 赤池雅史, 北市隆, 北川哲也, 佐田政隆 :
3D経食道心エコー法で診断できた僧帽弁位人工弁機能不全の一例,
第34回日本超音波検査学会, 2009年6月. 佐藤光代, 楠瀬賢也, 山田博胤, 冨田紀子, 西尾進, 平岡葉月, 佐田政隆 :
脳塞栓を契機に発見された左房腫瘍の1例,
第34回日本超音波検査学会, 2009年6月. 仁木敏之, 若槻哲三, 山口浩司, 楠瀬賢也, 小柴邦彦, 八木秀介, 竹谷善雄, 冨田紀子, 岩瀬俊, 山田博胤, 添木武, 赤池雅史, 佐田政隆 :
たこつぼ型心筋障害の亜型と考えられた左室mid-portion ballooningの二例,
第94回日本循環器学会中国・四国合同地方会, 2009年6月. 楠瀬賢也, 山田博胤, 冨田紀子, 仁木敏之, 山口浩司, 小柴邦彦, 八木秀介, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
心エコーによる心病変の経過観察が可能であった続発性(AA)アミロイドーシスの一例,
第94回日本循環器学会中国・四国合同地方会, 2009年6月. 小柴邦彦, 仁木敏之, 楠瀬賢也, 平田陽一郎, 山口浩司, 冨田紀子, 竹谷善雄, 八木秀介, 岩瀬俊, 山田博胤, 若槻哲三, 添木武, 赤池雅史, 佐田政隆 :
多発性筋炎に伴う心障害の一例,
第94回日本循環器学会中国・四国合同地方会, 2009年6月. 黒部裕嗣, 神原保, 吉田誉, 元木達夫, 菅野幹雄, 北市隆, 楠瀬賢也, 山田博胤, 佐田政隆, 北川哲也 :
塞栓症を契機に発見された乳頭状線維弾性腫の2例,
第94回日本循環器学会中国・四国合同地方会, 2009年6月. 楠瀬賢也, 山田博胤, 西尾進, 平岡葉月, 佐藤光代, 多田津陽子, 冨田紀子, 添木武, 赤池雅史, 佐田政隆 :
安静時post systolic shortening による虚血心筋の検出,
日本超音波医学会第82回学術集会, 2009年5月. 西尾進, 山田博胤, 楠瀬賢也, 平岡葉月, 佐藤光代, 多田津陽子, 冨田紀子, 添木武, 赤池雅史, 佐田政隆 :
下肢静脈血栓スクリーニング検査で発見されたベーカー嚢胞破裂の2症例,
日本超音波医学会第82回学術集会, 2009年5月. 八木秀介, 岩瀬俊, 赤池雅史, 山口浩司, 小柴邦彦, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
重症心不全患者における酸素療法とAdaptive-servo ventilator療法の効果の比較検討,
日本内科学会第100回四国地方会, 2009年5月. 吉田守美子, 粟飯原賢一, 西尾進, 倉橋清衛, 遠藤逸朗, 藤中雄一, 伊勢孝之, 住友由佳, 八木秀介, 岩瀬俊, 山田博胤, 赤池雅史, 佐田政隆, 松本俊夫 :
副腎アンドロゲンDHEASは血管内皮機能非依存的に頸動脈硬化を抑制する,
第82回日本内分泌学会学術総会, Vol.85, No.1, 366, 2009年4月.

(キーワード): *頸動脈疾患 *血管内皮 *動脈硬化症 *Dehydroepiandrosterone Sulfate(薬理学) ヒト男女

佐藤光代, 楠瀬賢也, 山田博胤, 西尾進, 平岡葉月, 冨田紀子, 仁木敏之, 山口浩司, 小柴邦彦, 八木秀介, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
経食道心エコー検査により治療経過が観察できた高安動脈炎に伴う肺動脈狭窄症の一例,
第20回日本心エコー図学会学術集会, 2009年4月. 平岡葉月, 山田博胤, 西尾進, 佐藤光代, 高松直子, 楠瀬賢也, 冨田紀子, 仁木敏之, 山口浩司, 小柴邦彦, 八木秀介, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
心エコーによる心病変の経過観察が可能であった続発性(AA)アミロイドーシスの一例,
第20回日本心エコー図学会学術集会, 2009年4月. 三木淳子, 西尾進, 佐藤光代, 平岡葉月, 井上千尋, 笹田倫子, 山田博胤 :
超音波センターにおける看護師の役割,
第20回日本心エコー図学会学術集会, 2009年4月. 高松直子, 山田博胤, 西尾進, 佐藤光代, 平岡葉月, 楠瀬賢也, 冨田紀子, 和泉唯信, 梶龍兒, 佐田政隆 :
麦角系アルカロイド剤を服用しているパーキンソン病患者の心エコー所見,
第20回日本心エコー図学会学術集会, 2009年4月. 西尾進, 山田博胤, 楠瀬賢也, 冨田紀子, 平岡葉月, 佐藤光代, 仁木敏之, 山口浩司, 小柴邦彦, 八木秀介, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
三尖弁輪運動速波形を用いた二次性肺高血圧の評価,
第20回日本心エコー図学会学術集会, 2009年4月. 楠瀬賢也, 山田博胤, 西尾進, 冨田紀子, 平岡葉月, 佐藤光代, 仁木敏之, 山口浩司, 小柴邦彦, 八木秀介, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
Post systolic shortening(PSS)による心筋虚血の検出,
第20回日本心エコー図学会学術集会, 2009年4月. 楠瀬賢也, 山田博胤, 西尾進, 冨田紀子, 平岡葉月, 佐藤光代, 仁木敏之, 山口浩司, 小柴邦彦, 八木秀介, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
僧帽弁口血流と僧帽弁輪運動の不整合は左室拡張能の評価に有用か:dual Doppler systemを用いた検討,
第20回日本心エコー図学会学術集会, 2009年4月. 山田博胤 :
キーノートレクチャー(1):僧帽弁口血流速波形の成り立ち,
第20回日本心エコー図学会学術集会, 2009年4月. 楠瀬賢也, 山田博胤, 西尾進, 仁木敏之, 冨田紀子, 山口浩司, 小柴邦彦, 八木秀介, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 河野智彦, 佐田政隆 :
右心不全を契機に診断された肺動脈狭窄症の一例,
第93回日本循環器学会四国地方会, 2008年12月. 八木秀介, 岩瀬俊, 楠瀬賢也, 仁木敏之, 山口浩司, 小柴邦彦, 冨田紀子, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
強皮症に伴う難治性末梢循環不全に対するエンドセリン受容体拮抗薬の有用性,
第93回日本循環器学会四国地方会, 2008年12月. 小柴邦彦, 添木武, 仁木敏之, 楠瀬賢也, 山口浩司, 冨田紀子, 八木秀介, 岩瀬俊, 山田博胤, 若槻哲三, 赤池雅史, 佐田政隆 :
両側肺血栓症と多発性体循環系塞栓症を合併した1例,
第93回日本循環器学会四国地方会, 2008年12月. 山口浩司, 若槻哲三, 仁木敏之, 楠瀬賢也, 小柴邦彦, 冨田紀子, 八木秀介, 岩瀬俊, 山田博胤, 添木武, 赤池雅史, 佐田政隆 :
冠動脈ステント3種(CYPHER, TAXUS, DRIVER)の慢性期病理組織所見の比較と局所凝固反応の関連性,
第93回日本循環器学会四国地方会, 2008年12月. 西尾進, 山田博胤, 楠瀬賢也, 佐藤光代, 高松直子, 添木武, 赤池雅史, 佐田政隆 :
頸動脈狭窄性病変におけるB-Flowの有用性,
第18回日本超音波医学会四国地方会学術集会, 2008年10月. 山中森晶, 楠瀬賢也, 山田博胤, 西尾進, 佐藤光代, 添木武, 赤池雅史, 佐田政隆 :
壁運動正常例におけるpost systolic shortening (PSS) についての検討,
第18回日本超音波医学会四国地方会学術集会, 2008年10月. 楠瀬賢也, 山田博胤, 西尾進, 佐藤光代, 添木武, 赤池雅史, 阿部美保, 河野和弘, 角谷昭佳, 佐田政隆 :
リアルタイム3次元経食道心エコー図で診断しえた肺動脈狭窄症の一例,
第18回日本超音波医学会四国地方会学術集会, 2008年10月. 西尾進, 山田博胤, 楠瀬賢也, 仁木敏之, 山口浩司, 八木秀介, 小柴邦彦, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 永峰康孝, 佐田政隆 :
Automated Function Imaging法による左室局所壁運動異常評価:心エコー初心者による肉眼的評価との比較,
第56回日本心臓病学会学術集会, 2008年9月. 楠瀬賢也, 山田博胤, 西尾進, 仁木敏之, 山口浩司, 八木秀介, 小柴邦彦, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
高血圧性心疾患における左房ポンプ機能の評価:Left Atrial Ejection Forceを用いた検討,
第56回日本心臓病学会学術集会, 2008年9月. 若槻哲三, 山口浩司, 仁木敏之, 楠瀬賢也, 小柴邦彦, 八木秀介, 岩瀬俊, 山田博胤, 添木武, 赤池雅史, 佐田政隆 :
薬剤溶出ステント植え込み後の冠動脈内皮機能障害と局所炎症遷延の関連性,
第56回日本心臓病学会学術集会, 2008年9月. 楠瀬賢也, 山田博胤, 西尾進, 仁木敏之, 山口浩司, 八木秀介, 小柴邦彦, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
心房細動におけるTEI indexの有用性:Dual Doppler法を用いた検討,
第56回日本心臓病学会学術集会, 2008年9月. 仁木敏之, 添木武, 小柴邦彦, 楠瀬賢也, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 若槻哲三, 赤池雅史, 福田大和, 篠原尚典, 福田信夫, 田村禎通, 佐田政隆 :
虚血性心疾患におけるHMGBI (high mobility group box 1) の診断的意義,
第56回日本心臓病学会学術集会, 2008年9月. 武知かおる, 山田博胤, 楠瀬賢也, 西尾進, 河野裕美, 平岡葉月, 佐藤光代, 添木武, 長楽雅仁, 前田泰弘 :
Automated Function Imaging法による左室局所壁運動異常評価のvalidation (VANILLA study),
第81回日本超音波医学会学術集会, 2008年5月. 岡田早未, 山田博胤, 楠瀬賢也, 佐藤光代, 平岡葉月, 西尾進, 河野裕美, 多田津陽子, 添木武, 赤池雅史 :
高血圧性心疾患における左室リモデリングと左室拡張能の関連,
第81回日本超音波医学会学術集会, 2008年5月. 佐藤光代, 山田博胤, 楠瀬賢也, 平岡葉月, 西尾進, 河野裕美, 多田津陽子, 添木武, 赤池雅史 :
高血圧患者における心電図の左房負荷は何を表しているか?-心エコー・ドプラ法による再検討-,
第81回日本超音波医学会学術集会, 2008年5月. 楠瀬賢也, 山田博胤, 河野裕美, 西尾進, 平岡葉月, 佐藤光代, 多田津陽子, 添木武, 赤池雅史 :
心房細動症例におけるTEI indexの有用性:Dual Doppler法を用いた検討,
第81回日本超音波医学会学術集会, 2008年5月. 平岡葉月, 山田博胤, 岡田早未, 楠瀬賢也, 佐藤光代, 河野裕美, 西尾進, 添木武 :
高血圧患者における左室肥大の心電図診断はどのくらい正確か?,
第19回日本心エコー図学会学術集会, 2008年4月. 楠瀬賢也, 武知かおる, 西尾進, 河野裕美, 平岡葉月, 佐藤光代, 添木武, 長楽雅仁, 前田泰弘, 山田博胤 :
Longitudinal Strainを用いたAutomated Function Imaging法による左室局所壁運動異常評価のvalidation (VANILLA study),
第19回日本心エコー図学会学術集会, 2008年4月. 西尾進, 山田博胤, 楠瀬賢也, 添木武, 河野裕美, 平岡葉月, 佐藤光代 :
陳旧性心筋梗塞症における前負荷増大時の心反応性には左房機能が関与する:左房容積曲線を用いた検討,
第19回日本心エコー図学会学術集会, 2008年4月. T Niki, Takeshi Soeki, Kenya Kusunose, K Yamaguchi, K Koshiba, Tomohito Kawano, Hirotsugu Yamada, Tetsuzo Wakatsuki and Kenji Kangawa :
Elevated Concentration of Interferon-Inducible Protein of 10kd (IP-10) is Associated with Coronary Atherosclerosis.,
72th Annual scientific meeting of the Japanese circulation society, Mar. 2008. K Yamaguchi, Tetsuzo Wakatsuki, Kenya Kusunose, T Niki, K Koshiba, Tomohito Kawano, Hirotsugu Yamada and Takeshi Soeki :
Predictors of Local Hypercoagulability after Sirolimus-Eluting Stent Implantation: Implication for Correlates of Late Stent Thrombosis.,
72th Annual scientific meeting of the Japanese circulation society, Mar. 2008. Takeshi Soeki, T Niki, K Koshiba, Kenya Kusunose, K Yamaguchi, Tomohito Kawano, Hirotsugu Yamada and Tetsuzo Wakatsuki :
Elevated Concentration of Pentraxin 3 is Associated with Coronary Plaque Vulnerability.,
72th Annual scientific meeting of the Japanese circulation society, Mar. 2008. Takeshi Soeki, K Koshiba, T Niki, Kenya Kusunose, K Yamaguchi, Tomohito Kawano, Hirotsugu Yamada, Tetsuzo Wakatsuki and Kenji Kangawa :
Ghrelin Attenuates Myocardial Ischemia/Reperfusion Injury via the Extracellular Signal-Regulated Kinase 1/2 and Phosphatidylinositol.,
72th Annual scientific meeting of the Japanese circulation society, Mar. 2008. Tetsuzo Wakatsuki, K Yamaguchi, T Niki, Kenya Kusunose, K Koshiba, Takeshi Soeki and Hirotsugu Yamada :
Long-Term Local Inflammatory Response after Coronary Artery Stenting with Drug-Eluting Stent.,
72th Annual scientific meeting of the Japanese circulation society, Mar. 2008. Kenya Kusunose, Hirotsugu Yamada, A Iga, T Niki, K Yamaguchi, K Koshiba, Takeshi Soeki and Tetsuzo Wakatsuki :
Left Atrial Volume dose not reflect Brain Natriuretic Peptide Levels in Patients with Atrial Fibrillation.,
72th Annual scientific meeting of the Japanese circulation society, Mar. 2008. Kenya Kusunose, Hirotsugu Yamada, A Iga, T Niki, K Yamaguchi, K Koshiba, Takeshi Soeki and Tetsuzo Wakatsuki :
Importance of Left Atrial Function for the Pseudonormalization of Transmitral Flow Velocity Pattern in Patients with Hypertrophic Cardiomyopathy.,
72th Annual scientific meeting of the Japanese circulation society, Mar. 2008. Hirotsugu Yamada, Kenya Kusunose, A Iga, T Niki, K Yamaguchi, K Koshiba, Takeshi Soeki and Tetsuzo Wakatsuki :
E/e' as a Predictor of the Cardiac Response to Increment of Preload in Patients with Atrial Fibrillation.,
72th Annual scientific meeting of the Japanese circulation society, Mar. 2008. Hirotsugu Yamada :
Tissue Doppler Imaging for evaluating hemodynamics.,
72th Annual meeting of Japanese Circulation Society, Mar. 2008. 楠瀬賢也, 山田博胤, 仁木敏之, 山口浩司, 小柴邦彦, 添木武, 若槻哲三, 八木秀介, 岩瀬俊, 赤池雅史, 阿部美保, 北川哲也 :
両心房腫瘤の一例,
第102回UCG談話会, 2008年2月. 山田博胤, 平岡葉月 :
ウルトラサウンド・ウルトラクイズ! 超音波の基礎知識をクイズ形式で学ぼう!,
第11回徳島超音波研究会, 2008年1月. 楠瀬賢也, 山田博胤, 岩瀬俊, 佐藤光代, 平岡葉月, 河野裕美, 三木淳子, 阿部美保, 北川哲也 :
両心房腫瘍の1例,
第11回徳島超音波研究会, 2008年1月. 仁木敏之, 添木武, 楠瀬賢也, 山口浩司, 小柴邦彦, 河野智仁, 山田博胤, 若槻哲三 :
特定の薬物療法が功を奏した心房頻拍の1例,
第97回日本内科学会四国地方会, 2007年12月. 楠瀬賢也, 添木武, 仁木敏之, 山口浩司, 小柴邦彦, 山田博胤, 若槻哲三, 八木秀介, 岩瀬俊, 赤池雅史 :
心エコーで心室中隔瘤の診断に苦慮した心サルコイドーシスの一例,
第91回日本循環器学会四国地方会学術集会, 2007年11月. 楠瀬賢也, 山田博胤, 佐藤光代, 平岡葉月, 河野裕美, 仁木敏之, 山口浩司, 小柴邦彦, 添木武, 若槻哲三 :
肥大型心筋症の僧帽弁口血流速波形における左房機能の影響:左房容積曲線を用いた検討,
第17回日本超音波医学会四国地方会学術集会, 2007年10月. 佐藤光代, 山田博胤, 楠瀬賢也, 岩瀬俊, 平岡葉月, 河野裕美, 仁木敏之, 山口浩司, 小柴邦彦, 河野智仁, 添木武, 若槻哲三 :
不可解な心電図異常を呈する親子,
第17回日本超音波医学会四国地方会学術集会, 2007年10月. 楠瀬賢也, 山田博胤, 岩瀬俊, 佐藤光代, 平岡葉月, 河野裕美, 三木淳子 :
不可解な心電図異常を呈する親子,
第49回徳島心エコー図研究会, 2007年9月. 楠瀬賢也, 山田博胤, 仁木敏之, 山口浩司, 小柴邦彦, 河野智仁, 添木武, 若槻哲三, 八木秀介, 岩瀬俊, 赤池雅史, 谷口哲三, 髙尾正一郎 :
不可解な心電図異常を呈し，肥大型心筋症を疑う1例,
第12回中国四国心筋症研究会, 2007年9月. 仁木敏之, 添木武, 楠瀬賢也, 山口浩司, 小柴邦彦, 河野智仁, 山田博胤, 若槻哲三 :
冠動脈硬化病変と血中ケモカイン濃度との関連性,
第55回日本心臓病学会学術集会, 2007年9月. 添木武, 仁木敏之, 楠瀬賢也, 山口浩司, 小柴邦彦, 河野智仁, 山田博胤, 若槻哲三 :
冠動脈硬化症と血漿pentraxin3(PTX3)値の関係,
第55回日本心臓病学会学術集会, 2007年9月. 山田博胤, 山崎聖広, 楠瀬賢也, 仁木敏之, 山口浩司, 小柴邦彦, 河野智仁, 添木武, 若槻哲三 :
断層心エコー法による左房容積の計測およびそれにおける僧帽弁逆流の影響,
第55回日本心臓病学会学術集会, 2007年9月. 小柴邦彦, 添木武, 仁木敏之, 楠瀬賢也, 山口浩司, 河野智仁, 山田博胤, 若槻哲三 :
C型ナトリウム利尿ペプチドは自己免疫性心筋炎の進展を抑制する,
第55回日本心臓病学会学術集会, 2007年9月. 山田博胤, 楠瀬賢也, 仁木敏之, 山口浩司, 小柴邦彦, 河野智仁, 添木武, 若槻哲三, 三代裕一郎 :
アンギオテンシンⅡ受容体拮抗薬(ARB)投与症例におけるインダパミド少量追加投与の効果,
第55回日本心臓病学会学術集会, 2007年9月. 楠瀬賢也, 山田博胤, 濱本秀一, 仁木敏之, 山口浩司, 小柴邦彦, 河野智仁, 添木武, 若槻哲三 :
心房細動における拡張早期僧帽弁輪運動速度の心室中隔側および左室側壁側における差の検討-Dual Doppler法を用いて-,
第55回日本心臓病学会学術集会, 2007年9月. 藤田浩司, 阿部秀一, 和泉唯信, 山田博胤, 森田直美, 原田雅史, 永廣信治, 梶龍兒 :
心筋障害・心房中隔瘤に伴い心原性脳塞栓症を呈したBecker型筋ジストロフィーの1例,
第9回徳島臨床脈管研究会, 2007年9月. 楠瀬賢也, 山田博胤 :
Constrictionとrestriction,
第9回徳島超音波研究会, 2007年6月. 楠瀬賢也, 山田博胤, 添木武, 佐藤光代, 河野裕美, 平岡葉月 :
改良された2D Tissue Tracking法を用いた左房容積変化の評価,
第80回日本超音波医学会学術集会, 2007年5月. 河野裕美, 山田博胤, 楠瀬賢也, 添木武, 佐藤光代, 平岡葉月, 永峰康孝 :
Dual-Doppler法を用いた僧帽弁口血流速および僧帽弁輪運動速波形の同時記録による左房細動における左室拡張能の評価,
第18回日本心エコー図学会学術集会, 2007年4月. 楠瀬賢也, 山田博胤, 添木武, 佐藤光代, 河野裕美, 平岡葉月, 永峰康孝 :
心房細動におけるRR間隔の変動に伴う僧帽弁輪運動速度の変化,
第18回日本心エコー図学会学術集会, 2007年4月. 山田博胤, 楠瀬賢也, 添木武, 佐藤光代, 河野裕美, 平岡葉月 :
心房細動における前負荷増大に伴う心反応性の下半身陽圧負荷およびDual Doppler法を用いた検討,
第18回日本心エコー図学会学術集会, 2007年4月. Kenya Kusunose, Hirotsugu Yamada, T Nakajima, T Niki, K Yamaguchi, K Koshiba, Tomohito Kawano, Takeshi Soeki, Tetsuzo Wakatsuki and Susumu Ito :
Simultaneously Recorded E/Ew Refletcts Plasma BNP Level in Patients with Atrial Fibrillation.,
71th Annual scientific meeting of the Japanese circulation society, Mar. 2007. 楠瀬賢也, 山田博胤, 中島智博, 仁木敏之, 福田大和, 山口浩司, 小柴邦彦, 河野智仁, 添木武, 若槻哲三, 伊東進 :
体位変換により出現する低酸素血症の診断にコントラスト心エコー法が有用であった一例,
第89回日本循環器学会四国地方会, 2006年12月. 中島智博, 添木武, 若槻哲三, 仁木敏之, 楠瀬賢也, 山口浩司, 小柴邦彦, 河野智仁, 山田博胤, 伊東進 :
PP間隔が不規則な上室性頻拍に対しCARTOを用いたAblationが有用であった1例,
第89回日本循環器学会四国地方会, 2006年12月. 多田真理枝, 住友由佳, 岩瀬俊, 粟飯原賢一, 赤池雅史, 東博之, 松本俊夫, 山田博胤 :
心不全症状を繰り返した心尖部肥大型心筋症の一例,
第89回日本循環器学会四国地方会, 2006年12月. 森一博, 早渕康信, 鈴木光二郎, 阪田美穂, 香美祥二, 山田博胤, 馬場隆博 :
Tissue tracking 法を用いた左室の「捻れ」の研究,
第25回小児循環動態研究会, 2006年10月. 楠瀬賢也, 山田博胤, 中島智博, 仁木敏之, 福田大和, 山口浩司, 小柴邦彦, 河野智仁, 添木武, 若槻哲三, 伊東進 :
体位変換により出現する低酸素血症の診断にコントラスト心エコー法が有用であった一例,
第16回日本超音波医学会四国地方会, 2006年10月. 若槻哲三, 福田大和, 山口浩司, 小柴邦彦, 河野智仁, 添木武, 山田博胤 :
薬剤溶出ステントは長期に冠動脈局所の内皮機能を障害する,
第54回日本心臓病学会学術集会, 2006年9月. 山田博胤, 福田大和, 山口浩司, 小柴邦彦, 河野智仁, 添木武, 若槻哲三 :
心房細動に対するCoupled Pacing におけるペーシング遅延時間の差による影響,
第54回日本心臓病学会学術集会, 2006年9月. 中島智博, 山田博胤, 楠瀬賢也, 仁木敏之, 山口浩司, 小柴邦彦, 河野智仁, 添木武, 若槻哲三, 伊東進 :
ヒト心房性利尿ペプチドの間歇投与が有効な拡張層家族性肥大型心筋症の1例,
第11回中四国心筋症・心不全研究会, 2006年9月. 楠瀬賢也, 山田博胤, 中島智博, 仁木敏之, 福田大和, 山口浩司, 小柴邦彦, 河野智仁, 添木武, 若槻哲三, 伊東進 :
体位変換により出現する低酸素血症の診断にコントラスト心エコー法が有用であった一例,
徳島心エコー図研究会, 2006年8月. 楠瀬賢也, 山田博胤, 中島智博, 仁木敏之, 福田大和, 山口浩司, 小柴邦彦, 河野智仁, 添木武, 若槻哲三, 伊東進 :
体位変換により出現する低酸素血症の診断にコントラスト心エコー法が有用であった一例,
第4回先進血管エコー研究会, 2006年8月. 楠瀬賢也, 山田博胤, 中島智博, 仁木敏之, 福田大和, 山口浩司, 小柴邦彦, 河野智仁, 添木武, 若槻哲三, 伊東進 :
体位変換性の低酸素血症の診断にコントラスト心エコー法が有用であった一例,
第98回UCG談話会, 2006年7月. 三木淳子, 山田博胤, 福野天, 佐藤光代, 河野裕美, 平岡葉月, 向井久美, 井上千尋 :
超音波検査室における看護師の役割,
日本超音波医学会第79回学術集会, 2006年5月. 山田博胤, 河野裕美, 福田大和, 添木武, 田畑智継, 伊東進 :
下半身陽圧負荷による僧帽弁口血流速波形の変化を用いた心房機能低下例の鑑別,
第17回日本心エコー図学会学術集会, 2006年4月. Tetsuzo Wakatsuki, Koji Yamaguchi, Kunihiko Koshiba, Tomohito Kawano, Takeshi Soeki, Yamato Fukuda, Hirotsugu Yamada and Susumu Ito :
Long-term endothelial dysfunction after coronary artery stenting with drug-eluting stent,
第70回日本循環器学会総会・学術集会, Mar. 2006. Takeshi Soeki, Yamato Fukuda, Kunihiko Koshiba, Koji Yamaguchi, Tomohito Kawano, Tomohito Kawano, Hirotsugu Yamada, Tetsuzo Wakatsuki, Masahiro Nomura, Kenji Kangawa and Susumu Ito :
Ghrelin Protects Myocardium Against Ischemia/Reperfusion Injury via Inhibiting Myocardial Apoptosis,
第70回日本循環器学会総会, Mar. 2006. Hirotsugu Yamada, H Motonari, Y Fukuda, K Yamaguchi, K Koshiba, Tomohito Kawano, Takeshi Soeki, Tetsuzo Wakatsuki and Susumu Ito :
Effect of Aging on Left Atrial Function Evaluated by 2D Tissue Tracking.,
70th Annual scientific meeting of the Japanese circulation society, Mar. 2006. Hirotsugu Yamada, Y Fukuda, K Yamaguchi, K Koshiba, Tomohito Kawano, Takeshi Soeki, Tetsuzo Wakatsuki, Susumu Ito and Y Mishiro :
The Effects of the Addition of Minimal Dose of Indapamide in Patients Receiving Angiotensin-II Receptor Blocker.,
70th Annual scientific meeting of the Japanese circulation society, Mar. 2006. 山口浩司, 若槻哲三, 福田大和, 小柴邦彦, 河野智仁, 山田博胤, 添木武, 岩瀬俊, 藤村光則, 赤池雅史, 東博之 :
たこつぼ型心筋障害の亜型と考えられた左室mid-portion ballooningの一例,
第87回日本循環器学会中国・四国合同地方会, 2005年11月. 河野裕美, 山田博胤, 福田大和, 添木武, 田畑智継, 伊東進 :
下半身陽圧負荷による僧帽弁口血流速波形の変化を用いた心房機能低下例の鑑別,
日本超音波医学会四国地方会第15回学術集会, 2005年10月. 若槻哲三, 山口浩司, 小柴邦彦, 河野智仁, 添木武, 福田大和, 山田博胤, 田畑智継, 森一博 :
川崎病既往成人例および一般高齢者における冠動脈病変の特徴の差異 ―冠動脈内温度変化の観点から―,
第53回日本心臓病学会学術集会, 2005年9月. 河野智仁, 福田大和, 渡部智紀, 山口浩司, 小柴邦彦, 山田博胤, 添木武, 若槻哲三, 田畑智継, 野村昌弘 :
本態性高血圧症におけるアゼルニジピンの自律神経活動に及ぼす影響についての検討,
第53回日本心臓病学会, 2005年9月. 河野智仁, 福田大和, 渡部智紀, 山口浩司, 小柴邦彦, 山田博胤, 添木武, 若槻哲三, 田畑智継, 野村昌弘 :
アトルバスタチンの抗酸化作用と冠動脈プラーク安定化の評価:16列マルチスライスCTを用いた検討,
第53回日本心臓病学会, 2005年9月. 赤川英三, 村和也, 田中伸明, 國近英樹, 波多野靖幸, 橋本亮, 田中健雄, 野瀬善夫, 山田博胤, 松崎益徳 :
ドブタミン負荷時の2D tissue tracking法による左室捻れ運動の検討:心内膜側と心外膜側での比較,
第53回日本心臓病学会学術集会, 2005年9月. 森一博, 山田博胤, 馬場隆博 :
進行性筋ジストロフィー(DMD)における「左室のねじれ」の研究:Tissue tracking法および新しい解析ソフトを用いて,
第53回日本心臓病学会学術集会, 2005年9月. 小柴邦彦, 河野智仁, 福田大和, 渡部智紀, 山口浩司, 山田博胤, 添木武, 若槻哲三, 田畑智継, 野村昌弘 :
ドキソルビシン心筋症ラットにおける顆粒球コロニー刺激因子投与によるアポトーシス抑制効果の検討,
第53回日本心臓病学会学術集会, 2005年9月. 小柴邦彦, 河野智仁, 福田大和, 渡部智紀, 山口浩司, 山田博胤, 添木武, 若槻哲三, 田畑智継, 野村昌弘 :
本態性高血圧症におけるアゼルニジピンの自律神経活動に及ぼす影響についての検討,
第53回日本心臓病学会学術集会, 2005年9月. 小柴邦彦, 河野智仁, 福田大和, 渡部智紀, 山口浩司, 山田博胤, 添木武, 若槻哲三, 田畑智継, 野村昌弘 :
アゼルニジピンによる抗動脈硬化作用および心肥大抑制作用の検討,
第53回日本心臓病学会学術集会, 2005年9月. 田畑智継, 山田博胤, 福田大和, 山口浩司, 小柴邦彦, 河野智仁, 添木武, 若槻哲三, 長野智章 :
2D tissue tracking 法を用いた左房容積変化の評価,
第53回日本心臓病学会学術集会, 2005年9月. 田畑智継, 山田博胤, 田中英治, 福田大和, 山口浩司, 小柴邦彦, 河野智仁, 添木武, 若槻哲三 :
ストレインイメージング法を用いた僧帽弁口血流速波形の偽正常化の再評価:左房機能との関係において,
第53回日本心臓病学会学術集会, 2005年9月. 山田博胤, 田畑智継, 本成永, 田中英治, 福田大和, 山口浩司, 小柴邦彦, 河野智仁, 添木武, 若槻哲三 :
2D組織トラッキング法を用いた左房リザーバー機能の評価,
第53回日本心臓病学会学術集会, 2005年9月. 田畑智継, 山田博胤 :
2D組織トラッキング法を用いた左房リザーバー機能の評価,
第3回先進心血管エコー研究会, 2005年8月. 山口浩司, 若槻哲三, 木村恵理子, 小柴邦彦, 河野智仁, 山田博胤, 田畑智継, 西角彰良, 野村昌弘, 楠完治, 伊東進, 来島敦史, 北川哲也 :
左心室造影にて偶然発見し得た左室microaneurysmの一例,
第86回日本循環器学会四国地方会, 2005年6月. 原田顕治, 山田博胤, 田畑智継, 伊賀彰子, 小柴邦彦, 山口浩司, 河野智仁, 若槻哲三, 西角彰良, 野村昌弘, 伊東進 :
多彩な心室壁の肥大形態を示した肥大型心筋症(HCM)の一家系,
日本超音波医学会四国地方会, 2005年6月. 山田博胤, 田畑智継, 原田顕治, 伊東進 :
心房細動除細動後の僧帽弁口血流速波形の偽拘束型パターンの成因,
第78回日本超音波医学会学術集会, 2005年5月. 山田博胤, 田畑智継, 原田顕治 :
肺静脈電気的隔離術における心腔内エコー図法(ICE)の役割,
第16回日本心エコー図学会学術集会, 2005年4月. T Watanabe, Masahiro Nomura, E Kimura, K Yamaguchi, K Koshiba, Tomohito Kawano, Hirotsugu Yamada, Tetsuzo Wakatsuki, Tomotsugu Tabata, Akiyoshi Nishikado, Yutaka Nakaya and Susumu Ito :
Antioxydative Effect and Atrial Electrophysiological Improvement by Candesartan in Hypertensive Patients.,
69th Annual scientific meeting of the Japanese circulation society, Mar. 2005. K Yamaguchi, Masahiro Nomura, E Kimura, T Watanabe, K Koshiba, Tomohito Kawano, Hirotsugu Yamada, Tetsuzo Wakatsuki, Tomotsugu Tabata, Akiyoshi Nishikado, Susumu Ito and Yutaka Nakaya :
Dose Obstructive Sleep Apnea Syndrome (OSAS) Cause the Myocardial Injury? Examination by 99mTc-MIBI Scintigraphy.,
69th Annual scientific meeting of the Japanese circulation sciety, Mar. 2005. K Yamaguchi, Masahiro Nomura, E Kimura, T Watanabe, K Koshiba, Tomohito Kawano, Hirotsugu Yamada, Tetsuzo Wakatsuki, Tomotsugu Tabata, Akiyoshi Nishikado, Susumu Ito and Yutaka Nakaya :
Effect of Carvedilol on Autonomic Nerves Function and Oxidative Stress in the Essential Hypertensive Patients with Obstructive Sleep Apnea Syndrome.,
69th Annual scientific meeting of the Japanese circulation society, Mar. 2005. K Yamaguchi, Masahiro Nomura, E Kimura, T Watanabe, K Koshiba, Tomohito Kawano, Hirotsugu Yamada, Tetsuzo Wakatsuki, Tomotsugu Tabata, Akiyoshi Nishikado, Susumu Ito and Yutaka Nakaya :
Atherosclerosis Suppression Effect of Estrogen: Is the Chronic Liver Disease Atherogenic?,
69th Annual scientific meeting of the Japanese circulation society, Mar. 2005. Masahiro Nomura, E Kimura, T Watanabe, K Yamaguchi, K Koshiba, Tomohito Kawano, Hirotsugu Yamada, Tetsuzo Wakatsuki, Tomotsugu Tabata, Akiyoshi Nishikado, Susumu Ito and Yutaka Nakaya :
Current Density Map at Ventricular Repolarization Phase in Myocardial Infarction.,
69th Annual scientific meeting of the Japanese circulation society, Mar. 2005. H Tanaka, T Oki, Y Mizuguchi, Y Oishi, S Emi, T Ishimoto, N Nagase, Hirotsugu Yamada and Tomotsugu Tabata :
Radial Deterioration of the Myocardial Contractility by High Dose Dobutamine Stress Precisely Evaluated by Tissue Strain Imaging.,
69th Annual scientific meeting of the Japanese circulation society, Mar. 2005. Hirotsugu Yamada, Tomotsugu Tabata, H Baba, K Yamaguchi, K Koshiba, Tomohito Kawano, Tetsuzo Wakatsuki, Masahiro Nomura and Susumu Ito :
Quantitative Assessment of Left Ventricular Torsion by Two-dimensional Echocardiographic Automated Tissue Tracking Techinique.,
69th Annual scientific meeting of the Japanese circulation society, Mar. 2005. Hirotsugu Yamada, T Mazgalev, JD Thomas, Tomotsugu Tabata, Masahiro Nomura and Susumu Ito :
Effect of AV Nodal Vagal Stimulation on Left Ventricular Function in Chronic Atrial Fibrillation Canine Model.,
69th Annual scientific meeting of the Japanese circulation society, Mar. 2005. 山田博胤, 田畑智継, 河野智仁, 山口浩司, 小柴邦彦, 若槻哲三, 西角彰良, 野村昌弘, 伊東進 :
拡大不全心における左房リザーバー機能の定量的評価:組織ストレインイメージングを用いた検討,
第85回日本循環器学会中国・四国合同地方会, 2004年11月. 小柴邦彦, 野村昌弘, 河野智仁, 山口浩司, 木村恵理子, 山田博胤, 若槻哲三, 田畑智継, 西角彰良, 伊東進 :
G-CSF の心筋への効果:アドリアマイシン心筋症ラットにおける検討,
第91回日本内科学会四国地方会, 2004年11月. 山田博胤, 田畑智継, 田中英治, 原田顕治, 伊東進 :
肺静脈電気的隔離術におけるPhased-array心腔内エコー (ICE) の役割,
第14回日本超音波医学会四国地方会, 2004年11月. 竹迫大神, R Ramchandran, Y Saad, 山田博胤, J Thomas, R Desnoyer, B Fink, D Harrison, S Karnik :
血管内皮細胞特異的アンジオテンシンⅡ1型受容体トランスジェニックマウスは降圧および陰性変事作用を起こす,
第27回日本高血圧学会, 2004年10月. 山田博胤 :
肥大型心筋症最近の話題,
ノバルティスファーマ学術研究会, 2004年9月. 田中英治, 田畑智継, 原田顕治, 山田博胤, 若槻哲三, 河野智仁, 山口浩司, 小柴邦彦, 野村昌弘 :
左室収縮は全周性に均一か?経胸壁および経食道心エコー法によって得られる心筋ストレインの比較,
第52回日本心臓病学会学術集会, 2004年9月.

(要約): 左室前壁側のストレインは後壁側よりも低値を示した．左室前壁側の収縮は後壁側よりも小で，左室短軸方向の収縮が全周性に均一でないことが判明した．

田畑智継, 田中英治, 原田顕治, 山田博胤, 若槻哲三, 河野智仁, 山口浩司, 小柴邦彦, 野村昌弘 :
ストレインイメージング法を用いた左房機能の評価:下半身陽圧負荷を用いた検討,
第52回日本心臓病学会学術集会, 2004年9月.

(要約): 下半身陽圧負荷を用いて，ストレインイメージング法により左房心筋のリザーバーおよびポンプ機能を評価した．

山田博胤, 田畑智継, 田中英治, 原田顕治, 木村恵理子, 野村昌弘 :
心房細動および心機能不全におけるCoupled Pacingの効果:心臓の機械的効率に関する検討,
第52回日本心臓病学会学術集会, 2004年9月.

(要約): 右室ペーシングして，イソフルレン過剰投与した麻酔科開胸犬で検討した．Coupled Pacing (CP)は，心不全を伴う頻脈性Afに対して有用な治療法となる．

田中英治, 田畑智継, 原田顕治, 山田博胤, 若槻哲三, 河野智仁, 山口浩司, 小柴邦彦, 野村昌弘 :
ストレインイメージング法を用いた左室収縮能の評価:健常例におけるradial, meridionalおよびcircumferential systolic strainの検討,
第52回日本心臓病学会学術集会, 2004年9月.

(要約): 左室収縮は短軸方向のthickeningと長軸および円周方向のshorteningの複合によって行われ，左室後壁の短軸方向のthiceningが最も大であった．

江藤陽子, 山田博胤, 宇野漢成, 竹中克 :
僧帽弁輪自動自動トラッキング法による僧帽弁林の変位の解析と左心機能,
第2回先進心血管エコー研究会, 2004年8月. 田中英治, 田畑智継, 原田顕治, 山田博胤, 若槻哲三, 河野智仁, 小柴邦彦, 山口浩司, 西角彰良, 野村昌弘, 伊東進 :
ストレインイメージング法を用いた左室収縮動態の詳細な評価:健常例におけるradial, meridional, circumferential systolic strainの検討,
第2回先進心血管エコー研究会, 2004年8月. 山口浩司, 野村昌弘, 小柴邦彦, 河野智仁, 木村恵理子, 山田博胤, 若槻哲三, 田畑智継, 西角彰良, 伊東進 :
酸素摂取量と血中ホモシステインとの関連性:トータル・ヘルス・プロモーション・プラン検診による検討,
第54回循環器負荷研究会, 2004年8月. H Tanaka, Tomotsugu Tabata, K Harada, E Kimura, Hirotsugu Yamada, Tetsuzo Wakatsuki, Masahiro Nomura and Susumu Ito :
Dose-by-dose assessment of left ventricular myocardial ischemia during high dose dobutamine stress echocardiography.,
68th Annual scientific meeting of the Japanese circulation society, Mar. 2004. Tomotsugu Tabata, H Tanaka, K Harada, E Kimura, Hirotsugu Yamada, Tetsuzo Wakatsuki, Masahiro Nomura and Susumu Ito :
Long term assessment in the morphologic change in hypertrophic cardiomyopathy since 1979 in our laboratory.,
68th Annual scientific meeting of the Japanese circulation society, Mar. 2004. Tomotsugu Tabata, H Tanaka, K Harada, E Kimura, Hirotsugu Yamada, Tetsuzo Wakatsuki, Masahiro Nomura and Susumu Ito :
Impact of Losartan on Geometric Change for an Improved LV Performance in Hypertensive Heart.,
68th Annual scientific meeting of the Japanese circulation society, Mar. 2004. 原田顕治, 田畑智継, 田中英治, 木村恵理子, 山田博胤, 大木崇 :
ストレインイメージング法を用いた肥大心における左室長軸方向の局所心筋収縮能の評価,
第14回日本心エコー図学会学術集会, 2003年4月. Tomotsugu Tabata, T Tanaka, E Kimura, K Harada, Hirotsugu Yamada and T Oki :
Assessment of left ventricular diastolic function independent of cardiac translation using newly developed tissue strain imaging with tissue tracking technique.,
67th Annual Scientific Meeting of the Japanese Circulation Society, Mar. 2003. H Tanaka, Tomotsugu Tabata, E Kimura, K Harada, Tetsuzo Wakatsuki, T Yamamoto, A Saito, K Uehara, N Kageyama, Akiyoshi Nishikado, Masahiro Nomura, Hirotsugu Yamada, Susumu Ito and T Oki :
Impact of Losartan on left ventricular myocardial function in hypertensive hypertrophy: assessment of myocardial velocity profile and plasma vasoactive peptide.,
67th Annual Scientific Meeting of the Japanese Circulation Society, Mar. 2003. H Tanaka, Tomotsugu Tabata, E Kimura, K Harada, Tetsuzo Wakatsuki, T Yamamoto, A Saito, K Uehara, N Kageyama, Akiyoshi Nishikado, Masahiro Nomura, Hirotsugu Yamada, Susumu Ito and T Oki :
Quantitative assessment of left ventricular myocardial viability during low dose dobutamine stress echocardiography in combination with color tissue Doppler imaging.,
67th Annual Scientific Meeting of the Japanese Circulation Society, Mar. 2003. K Harada, Tomotsugu Tabata, H Tanaka, E Kimura, Tetsuzo Wakatsuki, T Yamamoto, K Uehara, A Saito, N Kageyama, Akiyoshi Nishikado, Masahiro Nomura, Hirotsugu Yamada, Susumu Ito and T Oki :
Better choice of color tissue Doppler imaging coupled with high dose dobutamine stress echocardiography for detecting coronary artery stenosis.,
67th Annual Scientific Meeting of the Japanese Circulation Society, Mar. 2003. K Harada, Tomotsugu Tabata, H Tanaka, E Kimura, Tetsuzo Wakatsuki, T Yamamoto, A Saito, K Uehara, N Kageyama, Akiyoshi Nishikado, Masahiro Nomura, Hirotsugu Yamada, Susumu Ito and T Oki :
Longitudinal myocardial displacement and strain rate in hypertrophied heart evaluated by tissue strain imaging with Doppler tissue tracking technique.,
67th Annual Scientific Meeting of the Japanese Circulation Society, Mar. 2003. 原田賢治, 田畑智継, 田中英治, 木村恵理子, 若槻哲三, 山本隆, 斎藤彰浩, 上原康三, 蔭山徳人, 山田博胤, 大木崇 :
高容量ドブタミン負荷試験陽性例の局所壁運動速度分布の変化に関する検討,
第50回日本心臓病学会学術集会, 2002年9月. 田中英治, 田畑智継, 木村恵理子, 原田賢治, 若槻哲三, 山本隆, 斎藤彰浩, 上原康三, 蔭山徳人, 山田博胤, 大木崇 :
冠攣縮性狭心症におけるアセチルコリン負荷試験陰性例の局所心筋収縮能の評価:カラー組織ドプラ法を用いた新しい解析法による検討,
第50回日本心臓病学会学術集会, 2002年9月. 原田顕治, 田畑智継, 田中英治, 木村恵理子, 山田博胤, 大木崇 :
非対称性肥大型心筋症の長軸方向における局所心筋のdisplacementに関する検討,
第7回中四国心筋症研究会, 2002年9月. 田畑智継, 田中英治, 大木崇, 山田博胤, RA Grimm, TN Mazgalev, JD Thomas :
短時間の心房細動後の左房の機能的および電気的リモデリングの関係:経食道心エコー法を用いた検討,
第10回体腔内心血管エコー研究会, 2002年8月. 田中英治, 田畑智継, 木村恵理子, 山田博胤, 大木崇 :
組織ドプラ法を用いた収縮期左室心筋内速度分布の時相分析,
第75回日本超音波医学会学術集会, 2002年6月. H Tanaka, Tomotsugu Tabata, Tetsuzo Wakatsuki, T Yamamoto, A Saito, Hirotsugu Yamada, Susumu Ito and T Oki :
Detection of the subtle changes in the left ventricular myocardial contractility in patients with vasospastic angina during acethylcholine stress test.,
第66日本循環器学会学術集会, Apr. 2002. Tomotsugu Tabata, T Oki, H Tanaka, Tetsuzo Wakatsuki, T Yamamoto, A Saito, Hirotsugu Yamada and Susumu Ito :
Quantitative analysis of the left ventricular segmental contyractility in the normal subjects using newly developed angle-corrected tissue strain imaging.,
第66回日本循環器学会学術集会, Apr. 2002. Tomotsugu Tabata, T Oki, H Tanaka, Tetsuzo Wakatsuki, T Yamamoto, A Saito, Hirotsugu Yamada and Susumu Ito :
Novel index for evaluating wall motion abnormality using newly developed angle-corrected tissue Doppler imaging.,
第66回日本循環器学会学術集会, Apr. 2002. 木村恵理子, 田畑智継, 田中英治, 山田博胤, 大木崇 :
高血圧性肥大心における左室局所心筋収縮能の規定因子:組織ドプラ法による心筋内速度分布を用いた検討,
第13回日本心エコー図学会学術集会, 2002年4月. 山本隆, 若槻哲三, 西角彰良, 田中英治, 山田博胤, 田畑智継, 大木崇 :
通常型房室結節リエントリー性頻拍症における遅伝導路に対する高周波アブレーション後の逆行性心房興奮機序の検討,
第49回日本心臓病学会, 2001年9月. 田中英治, 田畑智継, 山田博胤, 松岡雅子, 影治好美, 真鍋和代, 山本隆, 若槻哲三, 大木崇 :
肥大型心筋症における収縮期の左室心筋内運動速度分布:新しく開発した組織ドプラ法の表示方法,
第49回日本心臓病学会, 2001年9月. 田中英治, 田畑智継, 山田博胤, 松岡雅子, 影治好美, 真鍋和代, 山本隆, 若槻哲三, 大木崇 :
心筋の虚血および壊死の非侵襲的評価:心筋内運動速度分布を用いた新しい解析法による検討,
第49回日本心臓病学会, 2001年9月. 田中英治, 田畑智継, 山田博胤, 松岡雅子, 影治好美, 真鍋和代, 山本隆, 若槻哲三, 大木崇 :
高血圧患者の左室弛緩異常におよぼすロサルタンの効果:組織ドプラ法を用いた新しい解析法による検討,
第49回日本心臓病学会, 2001年9月. Hirotsugu Yamada :
Tissue Doppler Imaging.,
Japanese College of Cardiology Annual Scientific Meeting, Sep. 2001. 田畑智継, 大木崇, 山田博胤, 田中英治, 伊東進, RA Grimm, TN Mazgalev, JD Thomas :
心房細動における左心耳の電気的，機械的および血行動態的関連:心腔内心エコー法による検討,
第74回日本超音波医学会, 2001年5月. 田中英治, 大木崇, 山田博胤, 田畑智継, 伊東進, 神田良一, 阿部康彦, 生田目富夫 :
高血圧性肥大心における拡張早期左室心筋内速度分布の評価:組織ドプラ法を用いた新しい解析法による検討,
第74回日本超音波医学会, 2001年5月. 多田拓司, 大木崇, 山田博胤, 田中英治, 山本隆, 影治好美, 真鍋和代, 田畑智継 :
高血圧心における心房収縮期の左室伸展性に関する短軸および長軸の役割:パルス組織ドプラ法を用いた検討,
第12回日本心エコー図学会, 2001年4月. 田中英治, 大木崇, 山田博胤, 田畑智継, 多田拓司, 山本隆, 神田良一, 阿部康彦, 生田目富夫 :
高血圧性肥大心における拡張早期左室心筋内速度分布の評価:組織ドプラ法を用いた新しい解析法による検討,
第12回日本心エコー図学会, 2001年4月. 田畑智継, 大木崇, 山田博胤, 田中英治, 山本隆, 多田拓司, R Grimm, T Mazgalev, T James :
心房細動における左心耳の電気的，機械的および血行動態的関連:心腔内心エコー法による検討,
第12回日本心エコー図学会, 2001年4月. 若槻哲三, 大木崇, 山本隆, 日浦教和, 多田拓司, 山田博胤, 酒部宏一, 若槻真吾 :
イヌ急性心筋梗塞モデル再灌流後の冠血流速波形の推移と病理所見の関連性,
第8回心血管内イメージング研究会, 2000年12月. Hirotsugu Yamada and T Oki :
Assessment of Left Ventricular Diastolic Function Using Tissue Doppler Imaging.,
Cardiac Functional Information Imaging Semminar, The 14th Japan Medical Engineering Society, Oct. 2000. 山本隆, 若槻哲三, 森下智文, 多田拓司, 日浦教和, 小野瀬由紀子, 山田博胤, 西角彰良, 大木崇 :
通常型房室結節リエントリー性頻拍症例におけるHis束電位記録部位-冠静脈洞開口部間心房筋の伝導特性に関する検討,
第48回日本心臓病学会, 2000年9月. 山田博胤, 大木崇, 小野瀬由紀子, 松岡雅子, 影治好美, 真鍋和代, 多田拓司, 山本隆, 若槻哲三 :
原発性肺高血圧における肺静脈血流速波形の特徴,
第48回日本心臓病学会, 2000年9月. 山田博胤, 大木崇, 小野瀬由紀子, 松岡雅子, 影治好美, 真鍋和代, 多田拓司, 山本隆, 若槻哲三 :
僧帽弁輪および左室壁運動速度波形を用いた拡大不全心の予後に関する検討,
第48回日本心臓病学会, 2000年9月. 日浦教和, 若槻哲三, 山本隆, 森下智文, 多田拓司, 西角彰良, 小野瀬由紀子, 山田博胤, 大木崇 :
アンジオテンシンⅡ受容体拮抗薬(カンデサルタン)による急性心筋虚血および再灌流時の不整脈予防効果についての検討,
第48回日本心臓病学会, 2000年9月. 三代裕一郎, 大木崇, 山田博胤, 松岡雅子, 小野瀬由紀子 :
高血圧患者に対するangiotensinⅡ受容体拮抗薬およびACE阻害薬の併用療法:心エコーおよび脳性ナトリウム利尿ペプチドを用いた検討,
第48回日本心臓病学会, 2000年9月. 山田博胤, 大木崇, 小野瀬由紀子, 松岡雅子, 多田拓司, 山本隆, 真鍋和代, 影治好美 :
原発性肺高血圧症における肺静脈血流速波形の検討,
第8回体腔内心血管エコー研究会, 2000年8月. 山田博胤 :
組織ドプラ法を用いた心アミロイドーシスにおける収縮期左室心筋内速度分布の評価:高血圧性肥大心との比較,
第73回日本超音波医学会, 2000年5月. 小野瀬由紀子, 大木崇, 山田博胤, 松岡雅子, 山本隆, 真鍋和代, 影治好美, 伊東進 :
記録フレームレート数の組織ドプラ指標に与える影響,
第73回日本超音波医学会, 2000年5月. 山田博胤, 大木崇, 小野瀬由紀子, 松岡雅子, 山本隆, 真鍋和代, 影治好美, 伊東進 :
経胸壁心エコー図を用いた簡易三次元構築法による左房容積の算出,
第73回日本超音波医学会, 2000年5月. 松岡雅子, 大木崇, 山田博胤, 小野瀬由紀子, 山本隆, 真鍋和代, 影治好美, 伊東進 :
肥大型心筋症における左室弛緩異常および拡張早期asynchronyの検出:組織ドプラ法を用いた評価,
第73回日本超音波医学会, 2000年5月. 小野瀬由紀子, 大木崇, 山田博胤, 松岡雅子, 山本隆, 真鍋和代, 影治好美 :
肺高血圧患者における三尖弁輪部運動速度を用いた右室拡張機能の検討,
第11回日本心エコー図学会, 2000年4月. 山田博胤, 大木崇, 小野瀬由紀子, 松岡雅子, 山本隆, 真鍋和代, 影治好美 :
経胸壁心エコー図を用いた簡易三次元構築による左房容積の計測,
第11回日本心エコー図学会, 2000年4月. 山田博胤, 大木崇, 小野瀬由紀子, 松岡雅子, 山本隆, 若槻哲三, 伊東進 :
肥大型心筋症における左室拡張期asynchronyの評価:組織ドプラ法を用いた検討,
第64回日本循環器学会総会, 2000年4月. 山田博胤, 大木崇, 小野瀬由紀子, 松岡雅子, 山本隆, 若槻哲三, 伊東進 :
組織ドプラ法を用いた心アミロイドーシスにおける左室心筋内速度分布の評価:高血圧性肥大心との比較,
第64回日本循環器学会総会, 2000年4月. 松岡雅子, 大木崇, 山田博胤, 小野瀬由紀子, 山本隆, 若槻哲三, 伊東進 :
陳旧性心筋梗塞症における拡張期局所僧帽弁輪運動速度の評価:パルス組織ドプラ法による検討,
第64回日本循環器学会総会, 2000年4月. 松岡雅子, 大木崇, 山田博胤, 小野瀬由紀子, 山本隆, 若槻哲三, 伊東進 :
肥大型心筋症における左室拡張期asynchronyの評価:MRI SPAMM tagging法による検討,
第64回日本循環器学会総会, 2000年4月. Hirotsugu Yamada, 大木崇, 三代裕一郎, 小野瀬由紀子, 松岡雅子, 真鍋和代, 影治好美 and Tomotsugu Tabata :
LEFT VENTRICULAR ASYNCHRONOUS RELAXATION ALONG THE LONG AXIS IN PATIENTS WITH PREVIOUS MYOCARDIAL INFARCTION: ASSESSMENT BY MITRAL ANNULAR MOTION VELOCITY OBTAINED FROM PULSED TISSUE DOPPLER IMAGING,
第3回日本心不全学会, Oct. 1999. 三代裕一郎, 大木崇, Hirotsugu Yamada, 小野瀬由紀子, 松岡雅子, 真鍋和代, 影治好美 and Tomotsugu Tabata :
RELATIONSHIP BETWEEN EARLY DIASTOLIC LEFT VENTRICULAR ASYNCHRONY AND MYOCARDIAL VIABILITY USING MITRAL ANNULAR DESCENT VELOCITY: A STUDY WITH LOW DOSE DOBUTAMINE STRESS PULSED TISSUE DOPPLER IMAGING,
第3回日本心不全学会, Oct. 1999. 三代裕一郎, 大木崇, 山田博胤, 小野瀬由紀子, 松岡雅子, 真鍋和代, 影治好美, 野村昌弘, 田畑智継 :
低用量angiotensin-Ⅱ負荷パルス組織ドプラ法を用いた肥大型心筋症の収縮能評価:123I-BMIPPシンチグラフィーによる洗い出し率との比較,
第47回日本心臓病学会, 1999年9月. 山田博胤, 大木崇, 三代裕一郎, 小野瀬由紀子, 松岡雅子, 影治好美, 真鍋和代, 野村昌弘, 田畑智継 :
組織ドプラ法を用いた肥大型心筋症における収縮期左室心筋速度勾配の評価:123I-BMIPPシンチグラフィーによる洗い出し率との比較,
第47回日本心臓病学会, 1999年9月. 山田博胤, 大木崇, 三代裕一郎, 小野瀬由紀子, 松岡雅子, 影治好美, 真鍋和代, 若槻哲三, 田畑智継 :
陳旧性心筋梗塞症における左室長軸方向の拡張期asynchronyの検出:組織ドプラ法による検討,
第47回日本心臓病学会, 1999年9月. 小野瀬由紀子, 大木崇, 三代裕一郎, 山田博胤, 松岡雅子, 真鍋和代, 影治好美, 田畑智継 :
Cilnidipineは高血圧症における左室拡張機能を改善する:パルスおよび組織ドプラ法を用いた検討,
第47回日本心臓病学会, 1999年9月. 山田博胤, 大木崇, 三代裕一郎, 小野瀬由紀子, 松岡雅子, 影治好美, 真鍋和代, 若槻哲三, 田畑智継 :
組織ドプラ法による心筋速度勾配を用いた心臓手術後心室中隔異常運動の検討,
第47回日本心臓病学会, 1999年9月. 小野瀬由紀子, 大木崇, 三代裕一郎, 山田博胤, 松岡雅子, 真鍋和代, 影治好美, 田畑智継, 若槻哲三 :
正常者における長軸および短軸方向の左室収縮様式の加齢による変化:組織ドプラ法による壁運動速度波形を用いた検討,
第47回日本心臓病学会, 1999年9月. 三代裕一郎, 大木崇, 山田博胤, 小野瀬由紀子, 松岡雅子, 真鍋和代, 影治好美, 野村昌弘, 田畑智継 :
心筋梗塞における左室長軸方向の拡張早期asynchronyと心筋viabilityとの関連性:ドブタミン負荷パルス組織ドプラ法を用いた検討,
第47回日本心臓病学会, 1999年9月. 山田博胤, 大木崇, 三代裕一郎, 小野瀬由紀子, 松岡雅子, 影治好美, 真鍋和代, 若槻哲三, 田畑智継 :
僧帽弁口血流速波形の心房収縮期波増高例における心房収縮期左室局所壁運動速波形の特徴,
第47回日本心臓病学会, 1999年9月. 小野瀬由紀子, 大木崇, 若槻哲三, 大石佳史, 山田博胤, 豊嶋敏弘, 三代裕一郎, 日浦教和 :
左冠動脈肺動脈起始(Bland-White-Garland症候群)症例における冠血流動態の特徴-Doppler flow wireによる検討-,
第7回体腔内心血管エコー研究会, 1999年8月. 阿部美保, 大木崇, 田畑智継, 三代裕一郎, 山田博胤, 小野瀬由紀子, 真鍋和代, 影治好美, 伊東進 :
コイル塞栓術を施行した成人動脈管開存症の1例,
第72回日本超音波医学会, 1999年6月. 三代裕一郎, 大木崇, 山田博胤, 阿部美保, 小野瀬由紀子, 真鍋和代, 影治好美, 田畑智継, 伊東進 :
AngiotensinⅡ負荷心エコーおよび組織ドプラ法による肥大型心筋症の左室収縮機能の評価,
第72回日本超音波医学会, 1999年6月. 小野瀬由紀子, 大木崇, 三代裕一郎, 山田博胤, 阿部美保, 真鍋和代, 影治好美, 田畑智継, 伊東進 :
正常者における加齢による左室収縮様式の変化:組織ドプラ法による壁運動速度波形を用いた検討,
第72回日本超音波医学会, 1999年6月. 小野瀬由紀子, 大木崇, 三代裕一郎, 山田博胤, 阿部美保 :
Cilnidipineの左室拡張能に及ぼす影響:組織ドプラ法を用いて,
第10回日本心エコー図学会, 1999年5月. 三代裕一郎, 大木崇, 山田博胤, 阿部美保, 小野瀬由紀子 :
僧帽弁輪運動速度を用いた心筋viabilityの評価:低用量ドブタミン負荷パルス組織ドプラ法による検討,
第10回日本心エコー図学会, 1999年5月. 山田博胤, 大木崇, 三代裕一郎, 阿部美保, 小野瀬由紀子 :
心筋速度勾配による心臓手術後心室中隔異常運動の検討,
第10回日本心エコー図学会, 1999年5月. 阿部美保, 大木崇, 田畑智継, 三代裕一郎, 山田博胤, 小野瀬由紀子, 真鍋和代, 影治好美 :
不全心における心房収縮期の左房・左室間hemodynamic mismatchの検出:組織ドプラ法を用いた検討,
第10回日本心エコー図学会, 1999年5月. 阿部美保, 大木崇, 三代裕一郎, 山田博胤, 小野瀬由紀子, 真鍋和代, 影治好美, 田畑智継, 伊東進 :
高血圧性肥大心における心房収縮期の左室拡張様式の特徴:組織ドプラ法による検討,
第63回日本循環器学会総会, 1999年3月. 山田博胤, 大木崇, 三代裕一郎, 阿部美保, 小野瀬由紀子, 近藤幸, 由岐中道子, 野村昌弘, 伊東進 :
組織ドプラ法を用いた肥大型心筋症における左室心筋速度勾配の評価:123I-BMIPPシンチグラフィーによる洗い出し率との比較,
第63回日本循環器学会総会, 1999年3月. 三代裕一郎, 大木崇, 山田博胤, 阿部美保, 小野瀬由紀子, 真鍋和代, 影治好美, 伊東進 :
健常心における後負荷増大時の収縮期左室asynchrony:angiotensin Ⅱ負荷によるパルス組織ドプラ法を用いた検討,
第63回日本循環器学会総会, 1999年3月. 三代裕一郎, 大木崇, 山田博胤, 阿部美保, 小野瀬由紀子, 真鍋和代, 影治好美, 伊東進 :
後負荷心エコーおよび組織ドプラ法による肥大型心筋症の左室収縮機能の評価,
第63回日本循環器学会総会, 1999年3月. Hirotsugu Yamada, T Oki, Tomotsugu Tabata, Y Mishiro, M Abe, Y Onose and A Iuchi :
Tissue Doppler imaging-Clinical applications. Assessment of the systolic left ventricular myocardial velocity profile in hypertrophic cardiomyopathy using tissue Dopller imaging.(symposium),
10th Congress of the International Cardiac Doppler Society, Nov. 1998. 三代裕一郎, 大木崇, 山田博胤, 阿部美保, 小野瀬由紀子, 若槻哲三, 大石佳史, 井内新, 田畑智継, 真鍋和代, 影治好美 :
組織ドプラ法による収縮期左室壁運動速度波形の検討:左室内圧曲線のpeak dP/dtとの比較,
第46回日本心臓病学会, 1998年9月. 阿部美保, 大木崇, 田畑智継, 三代裕一郎, 山田博胤, 小野瀬由紀子, 井内新 :
肥大心および健常高齢者における心房収縮期左室壁伸展性の差異:組織ドプラ法を用いた検討,
第46回日本心臓病学会, 1998年9月. 山田博胤, 大木崇, 田畑智継, 三代裕一郎, 阿部美保, 小野瀬由紀子, 福田和代, 真鍋和代, 影治好美, 井内新 :
各種心筋症における左室長軸方向および短軸方向の収縮期壁運動速度の差異:パルス組織ドプラ法を用いた検討,
第46回日本心臓病学会, 1998年9月. 三代裕一郎, 大木崇, 山田博胤, 阿部美保, 小野瀬由紀子, 井内新, 田畑智継, 真鍋和代, 影治好美, 福田和代 :
健常者における急性後負荷増大による左室局所壁運動の変化:組織ドプラ法を用いた検討,
第46回日本心臓病学会, 1998年9月. 阿部美保, 大木崇, 田畑智継, 三代裕一郎, 山田博胤, 小野瀬由紀子, 真鍋和代, 影治好美, 福田和代, 井内新 :
大動脈弁閉鎖不全症および僧帽弁閉鎖不全症における収縮期壁運動に関する検討:組織ドプラ法を用いて,
第46回日本心臓病学会, 1998年9月. 山田博胤, 大木崇, 三代裕一郎, 阿部美保, 小野瀬由紀子, 真鍋和代, 田畑智継, 井内新, 伊東進 :
肺静脈血流速波形の収縮期第1波高と左房弛緩に関する検討,
第6回体腔内心血管エコー研究会, 1998年8月. 阿部美保, 大木崇, 田畑智継, 真鍋和代, 福田和代, 山田博胤, 小野瀬由紀子, 影治好美, 井内新, 伊東進 :
肥大及び健常高齢者における心房収縮期左室壁伸展性の差異-組織ドプラ法を用いた検討-,
第71回日本超音波医学会, 1998年5月. 福田和代, 大木崇, 田畑智継, 真鍋和代, 山田博胤, 阿部美保, 小野瀬由紀子, 影治好美, 井内新, 伊東進 :
健常者における急性後負荷増大による左室局所壁運動の変化-組織ドプラ法を用いた検討-,
第71回日本超音波医学会, 1998年5月. 小野瀬由紀子, 大木崇, 田畑智継, 山田博胤, 阿部美保, 真鍋和代, 福田和代, 影治好美, 井内新, 伊東進 :
心房収縮期における左室流入様式の検討-組織ドプラ法による左室壁運動速度波形と僧帽弁口血流速波形の比較-,
第71回日本超音波医学会, 1998年5月. 山田博胤, 大木崇, 田畑智継, 福田和代, 阿部美保, 小野瀬由紀子, 真鍋和代, 影治好美, 井内新, 伊東進 :
健常者における急性後負荷増大による左室局所壁運動の変化:組織ドプラ法を用いた検討,
第95回日本内科学会総会, 1998年4月. 小野瀬由紀子, 大木崇, 井内新, 田畑智継, 山田博胤, 阿部美保, 真鍋和代, 福田和代, 影治好美 :
肺梗塞を合併した真菌性感染症心内膜炎の1例,
第9回日本心エコー図学会, 1998年4月. 福田和代, 大木崇, 井内新, 田畑智継, 山田博胤, 阿部美保, 小野瀬由紀子, 真鍋和代, 影治好美, 若槻哲三, 伊東進 :
組織ドプラ法を用いた心房細動例における収縮期左室後壁運動速度の検討:心周期変動による波高変化とその臨床的意義,
第9回日本心エコー図学会, 1998年4月. 山田博胤, 大木崇, 田畑智継, 阿部美保, 小野瀬由紀子, 福田和代, 真鍋和代, 影治好美, 井内新 :
組織ドプラ法を用いた肥大型心筋症における拡張期心筋速度勾配の検討,
日本心エコー図学会, 1998年4月. 阿部美保, 大木崇, 田畑智継, 山田博胤, 小野瀬由紀子, 真鍋和代, 影治好美, 福田和代, 井内新 :
大動脈弁および僧帽弁閉鎖不全症における拡張早期の左室壁運動と左室流入との時間的関係,
第9回日本心エコー図学会, 1998年4月. 福田和代, 大木崇, 田畑智継, 真鍋和代, 山田博胤, 阿部美保, 小野瀬由紀子, 井内新, 伊東進 :
心筋梗塞症における左室局所壁運動異常と僧帽弁輪運動速度との関連性について:組織ドプラ法による検討,
第62回日本循環器学会総会, 1998年3月. 井内新, 大木崇, 田畑智継, 真鍋和代, 福田和代, 山田博胤, 阿部美保, 小野瀬由紀子, 伊東進, 田岡良章, 原田雅史, 西谷弘, 滝沢修 :
組織ドプラ法を用いた肥大型心筋症における左室拡張動態の検討:MRI tagging法による左室心筋の力学的歪み解析と対比,
第62回日本循環器学会総会, 1998年3月. 田畑智継, 大木崇, 山田博胤, 阿部美保, 小野瀬由紀子, 福田和代, 真鍋和代, 井内新, 伊東進 :
肺静脈血流速波形および心房中隔運動を用いた左房弛緩異常の評価,
第62回日本循環器学会総会, 1998年3月. 井内新, 大木崇, 田畑智継, 真鍋和代, 福田和代, 山田博胤, 阿部美保, 小野瀬由紀子, 伊東進, 田岡良章, 原田雅史, 西谷弘, 滝沢修 :
MRI SPAMM tagging法を用いた肥大型心筋症における左室心筋収縮動態の評価:時相分析を加えた力学的歪み解析による検討,
第62回日本循環器学会総会, 1998年3月. 藤永裕之, 若槻哲三, 山田博胤, 豊嶋敏弘, 井形次郎, 酒部宏一, 大石佳史, 西角彰良, 大木崇 :
収縮性心膜炎における冠動脈血流速波形の特徴-心膜切除前後での検討-,
第5回心血管内イメージング研究会, 1997年12月. 阿部美保, 大木崇, 田畑智継, 真鍋和代, 福田和代, 山田博胤, 小野瀬由紀子, 井内新, 伊東進 :
肺癌の左房内転移により僧帽弁口および肺静脈血流速波形に興味ある変化をきたした一例,
第70回日本超音波医学会, 1997年11月. 山田博胤, 大木崇, 田畑智継, 阿部美保, 小野瀬由紀子, 真鍋和代, 福田和代, 井内新, 伊東進 :
組織ドプラ法を用いた肥大型心筋症における左室心筋内速度分布の評価,
第70回日本超音波医学会, 1997年11月. 小野瀬由紀子, 大木崇, 田畑智継, 山田博胤, 阿部美保, 真鍋和代, 福田和代, 井内新, 伊東進 :
各種血行動態異常における拡張早期の左室拡張様式の差異:組織ドプラ法による壁運動速度波形と僧帽弁口血流速波形の比較,
第70回日本超音波医学会, 1997年11月. 阿部美保, 大木崇, 田畑智継, 山田博胤, 真鍋和代, 福田和代, 小野瀬由紀子, 井内新, 伊東進 :
各種病態における拡張末期の左室後壁および自由壁僧帽弁輪運動速度波形の差異:組織ドプラ法による検討,
第1回日本心不全学会, 1997年10月. 田畑智継, 大木崇, 山田博胤, 福田和代, 阿部美保, 小野瀬由紀子, 若槻哲三, 西角彰良, 井内新, 伊東進 :
左心耳機能と血中心房性ナトリウム利尿ペプタイド濃度の関係,
第1回日本心不全学会, 1997年10月. 山田博胤, 大木崇, 田畑智継, 真鍋和代, 福田和代, 阿部美保, 小野瀬由紀子, 井内新 :
左室完全型心膜欠損症における左室壁運動異常の評価:組織ドプラ法による心筋速度勾配を用いた検討,
第45回日本心臓病学会, 1997年9月. 福田信夫, 武市直樹, 添木武, 篠原尚典, 由井靖子, 田村禎通, 田畑智継, 井内新, 山田博胤, 大木崇 :
左室流出路狭窄における血中ナトリウム利尿ペプチド(ANP, BNP)濃度測定の意義,
第45回日本心臓病学会, 1997年9月. 田畑智継, 大木崇, 山田博胤, 真鍋和代, 福田和代, 阿部美保, 小野瀬由紀子, 井内新 :
組織ドプラ法を用いた左心系心疾患における僧帽弁輪運動の規定因子に関する再検討,
第45回日本心臓病学会, 1997年9月. 阿部美保, 大木崇, 田畑智継, 山田博胤, 真鍋和代, 福田和代, 小野瀬由紀子, 井内新 :
各種病態における拡張末期の左室後壁および自由壁僧帽弁輪運動速度波形の差異:組織ドプラ法による検討,
第45回日本心臓病学会, 1997年9月. 田畑智継, 大木崇, 山田博胤, 福田和代, 阿部美保, 若槻哲三, 藤永裕之, 酒部宏一, 西角彰良, 井内新 :
左心耳機能と血中心房性ナトリウム利尿ペプタイド濃度の関係,
第45回日本心臓病学会, 1997年9月. 阿部美保, 大木崇, 田畑智継, 山田博胤, 真鍋和代, 福田和代, 小野瀬由紀子, 井内新 :
大動脈弁閉鎖不全症および僧帽弁閉鎖不全症における拡張期左室壁運動速度の相違に関する検討:組織ドプラ法を用いて,
第45回日本心臓病学会, 1997年9月. 山田博胤, 大木崇, 田畑智継, 阿部美保, 小野瀬由紀子, 若槻哲三, 藤永裕之, 酒部宏一, 西角彰良, 井内新 :
収縮期心膜炎における右室および左室壁運動速度の評価の診断的有用性:組織ドプラ法を用いた検討,
第45回日本心臓病学会, 1997年9月. 井内新, 大木崇, 田畑智継, 真鍋和代, 福田和代, 山田博胤, 阿部美保, 小野瀬由紀子 :
2次元ベクトルを考慮した組織ドプラ法による健常者と高血圧心における左室壁運動速度の評価,
第45回日本心臓病学会, 1997年9月. 小野瀬由紀子, 大木崇, 田畑智継, 山田博胤, 阿部美保, 真鍋和代, 福田和代, 井内新 :
各種血行動態異常における拡張早期の左室拡張様式の差異:組織ドプラ法による壁運動速度波形と僧帽弁口血流速波形の比較において,
第45回日本心臓病学会, 1997年9月. 井内新, 大木崇, 田畑智継, 真鍋和代, 影治好美, 佐々木美和, 山田博胤, 福田信夫, 伊東進 :
洞調律の各種心筋疾患の左心耳内血流に及ぼす左房圧の影響に関する検討,
第3回体腔内心血管エコー研究会, 1997年8月. 阿部美保, 大木崇, 田畑智継, 山田博胤, 真鍋和代, 福田和代, 小野瀬由紀子, 井内新 :
大動脈弁閉鎖不全症および僧帽弁閉鎖不全症における拡張期左室壁運動速度の差異に関する検討:組織ドプラ法を用いて,
第8回弁と弁疾患研究会, 1997年8月. 福田和代, 大木崇, 田畑智継, 真鍋和代, 山田博胤, 阿部美保, 井内新, 伊東進 :
組織ドプラ法を用いた健常者の左室収縮および拡張動態の特徴に関する検討,
第61回日本循環器学会学術集会, 1997年3月. 田畑智継, 大木崇, 山田博胤, 阿部美保, 若槻哲三, 酒部宏一, 井形次郎, 西角彰良, 井内新, 伊東進 :
組織ドプラ法を用いた左房収縮時のelectrical and mechanical discordanceの検討,
第61回日本循環器学会学術集会, 1997年3月. 山田博胤, 大木崇, 田畑智継, 真鍋和代, 福田和代, 阿部美保, 若槻哲三, 酒部宏一, 井形次郎, 西角彰良, 井内新, 伊東進 :
拡大心における二次性僧帽弁逆流は僧帽弁口および肺静脈血流速波形に影響を与えるか?,
第61回日本循環器学会学術集会, 1997年3月. 酒部宏一, 若槻哲三, 藤永裕之, 井形次郎, 阿部美保, 山田博胤, 田畑智継, 井内新, 西角彰良, 大木崇, 伊東進 :
急性心筋梗塞再灌流直後の冠血流速パターンと病理所見の関係,
第61回日本循環器学会学術集会, 1997年3月. 若槻哲三, 大木崇, 酒部宏一, 井形次郎, 藤永裕之, 西角彰良, 阿部美保, 山田博胤, 田畑智継, 井内新, 伊東進 :
急性心筋梗塞direct PTCA後の冠血流速パターンの推移と左室局所壁運動の改善との関連性,
第61回日本循環器学会学術集会, 1997年3月. 酒部宏一, 若槻哲三, 井形次郎, 藤永裕之, 西角彰良, 阿部美保, 山田博胤, 田畑智継, 井内新, 大木崇, 伊東進 :
急性心筋梗塞direct PTCA後の冠血流速波形の推移と局所壁運動の改善と関連性,
第4回心血管内イメージング研究会, 1996年12月. 山田博胤, 大木崇, 田畑智継, 真鍋和代, 福田和代, 阿部美保, 井内新 :
左側完全型心膜欠損症における心室中隔異常運動の発生機序:断層心エコー法および組織ドプラ法による検討,
第44回日本心臓病学会, 1996年9月. 阿部美保, 大木崇, 田畑智継, 山田博胤, 真鍋和代, 福田和代, 井内新 :
組織ドプラ法を用いた大動脈弁閉鎖不全症における左室壁運動の評価,
第44回日本心臓病学会, 1996年9月. 酒部宏一, 西角彰良, 若槻哲三, 井形次郎, 井内新, 野村昌弘, 田畑智継, 山田博胤, 大木崇 :
心房細動時の心房内電位測定の除細動成否予測における有用性,
第44回日本心臓病学会, 1996年9月. 田畑智継, 大木崇, 井内新, 山田博胤, 阿部美保, 加藤逸夫, 北川哲也, 堀隆樹, 大下修造, 北畑洋 :
左心耳の左房血行動態におよぼす影響:心臓手術中における左心耳クランプによる検討,
第44回日本心臓病学会, 1996年9月. 酒部宏一, 若槻哲三, 井形次郎, 阿部美保, 山田博胤, 田畑智継, 井内新, 西角彰良, 大木崇, 伊東進 :
急性心筋梗塞再灌流直後の冠血流パターンと心筋微小循環障害およびその病理所見との関連,
第4回体腔内血管エコー研究会, 1996年8月. 山田博胤, 大木崇, 田畑智継, 真鍋和代, 福田和代, 阿部美保, 井内新, 伊東進 :
拡大心における二次性僧帽弁逆流は僧帽弁口および肺静脈血流速波形に影響を及ぼすか?,
第7回弁と弁疾患研究会, 1996年8月. 福田信夫, 四宮寛彦, 添木武, 武市直樹, 篠原尚典, 由井靖子, 田村禎通, 田畑智継, 井内新, 山田博胤, 阿部美保, 大木崇 :
左室流出路狭窄における脳性ナトリウム利尿ペプチドの分泌動態,
第7回弁と弁疾患研究会, 1996年8月. 山田博胤, 大木崇, 井内新, 田畑智継, 真鍋和代, 福田和代, 佐々木美和, 阿部美保 :
非対称性中隔肥大型心筋症および前壁心筋梗塞における代償的左室後壁運動の評価:組織ドプラ法を用いて,
第7回日本心エコー図学会, 1996年7月. 福田和代, 大木崇, 井内新, 田畑智継, 山田博胤, 真鍋和代, 佐々木美和, 阿部美保 :
左心耳内血流速波形を用いた心房細動除細動成否の予測,
第7回日本心エコー図学会, 1996年7月. 阿部美保, 大木崇, 井内新, 田畑智継, 山田博胤, 真鍋和代, 福田和代, 佐々木美和 :
肥大心における左室拡張能の評価:組織ドプラ法による検討,
第7回日本心エコー図学会, 1996年7月. 三代裕一郎, 大木崇, 井内新, 田畑智継, 山田博胤, 真鍋和代, 福田和代, 佐々木美和, 阿部美保 :
若年健常者における生理的僧帽弁逆流の特徴とその発生機序に関する一考察,
第7回日本心エコー図学会, 1996年7月. 田畑智継, 大木崇, 井内新, 山田博胤, 真鍋和代, 福田和代, 佐々木美和, 河原啓治, 福田信夫, 伊東進 :
組織ドプラ法による肥大心の左室収縮機能の評価,
第67回日本超音波医学会, 1996年6月. 山田博胤, 大木崇, 井内新, 田畑智継, 真鍋和代, 福田和代, 佐々木美和, 福田信夫, 伊東進 :
左側完全型心膜欠損症における心室中隔の収縮期および拡張期異常運動の発生機序:断層心エコー法および組織ドプラ法による検討,
第67回日本超音波医学会, 1996年6月. 田畑智継, 大木崇, 井内新, 真鍋和代, 福田和代, 佐々木美和, 山田博胤, 伊東進 :
各種心筋疾患の洞調律例における左心耳内血流速波形に対する左房圧の影響に関する検討,
第93回日本内科学会, 1996年4月. 井内新, 大木崇, 田畑智継, 真鍋和代, 福田和代, 山田博胤, 佐々木美和, 伊東進 :
心房細動例における肺静脈血流速波形の収縮初期陰性波に関する検討,
第93回日本内科学会, 1996年4月. 山田博胤, 大木崇, 井内新, 田畑智継, 真鍋和代, 福田和代, 佐々木美和, 伊東進 :
肺静脈および僧帽弁口血流速波形を用いた僧帽弁狭窄における左房収縮寄与に関する検討,
第60回日本循環器学会総会, 1996年3月. 佐々木美和, 大木崇, 井内新, 田畑智継, 真鍋和代, 福田和代, 山田博胤, 伊東進 :
本態性高血圧症におけるACE遺伝子多型とACE阻害薬投与による左室拡張能改善効果との関連性:心エコー・ドップラー法による検討,
第60回日本循環器学会総会, 1996年3月. 佐々木美和, 大木崇, 井内新, 田畑智継, 真鍋和代, 福田和代, 山田博胤, 伊東進 :
非対称性肥大型心筋症および前壁心筋梗塞における代償的左室後壁運動の評価:組織ドプラ法を用いて,
第60回日本循環器学会総会, 1996年3月. 山田博胤, 大木崇, 井内新, 田畑智継, 真鍋和代, 福田和代, 佐々木美和, 伊東進 :
健常者における加齢による左室拡張動態の変化:組織ドプラ法による検討,
第60回日本循環器学会総会, 1996年3月. 田畑智継, 大木崇, 井内新, 真鍋和代, 福田和代, 佐々木美和, 山田博胤, 伊東進 :
肥大心における左室拡張能の評価:組織ドプラ法による検討,
第60回日本循環器学会総会, 1996年3月. 田畑智継, 大木崇, 井内新, 真鍋和代, 佐々木美和, 山田博胤, 西角彰良, 若槻哲三, 篠原尚典, 酒部宏一, 福田信夫, 伊東進 :
組織ドプラ法を用いた左室拡張動態の評価:左室圧下降脚時定数Tauとの比較,
第60回日本循環器学会総会, 1996年3月. 酒部宏一, 若槻哲三, 篠原尚典, 西角彰良, 山田博胤, 田畑智継, 井内新, 大木崇 :
梗塞血管再灌流直後の冠血流パターンと心筋微小循環障害との関係:雑種成犬急性心筋梗塞モデルにおける検討,
第3回心血管内イメージング研究会, 1995年12月. 三代裕一郎, 福田信夫, 井内新, 田畑智継, 真鍋和代, 佐々木美和, 山田博胤, 大木崇, 伊東進 :
拡張早期に左室壁の特異な異常運動とknock sound様過剰心音を認めた高血圧心の1例,
第66回日本超音波医学会, 1995年11月. 山田博胤, 大木崇, 福田信夫, 井内新, 田畑智継, 真鍋和代, 影治好美, 佐々木美和, 伊東進 :
健常者における左室局所壁運動速度の評価:組織ドプラ法を用いた検討,
第66回日本超音波医学会, 1995年11月. 井内新, 大木崇, 田畑智継, 真鍋和代, 影治好美, 佐々木美和, 山田博胤, 福田信夫 :
心房細動時における左心耳内血流速波形の鋸歯状波形の特徴について,
第43回日本心臓病学会, 1995年9月. 真鍋和代, 大木崇, 井内新, 田畑智継, 影治好美, 佐々木美和, 山田博胤, 福田信夫 :
左心耳内血流速度と左房booster pump機能に関する検討,
第43回日本心臓病学会, 1995年9月. 田畑智継, 大木崇, 井内新, 真鍋和代, 影治好美, 佐々木美和, 山田博胤, 福田信夫 :
洞調律の各種心疾患の左心耳内血流速波形に対する左房圧の影響について,
第43回日本心臓病学会, 1995年9月. 井内新, 大木崇, 福田信夫, 田畑智継, 真鍋和代, 影治好美, 佐々木美和, 山田博胤 :
組織ドプラ法による僧帽弁輪移動速度の評価:健常者と肥大心における対比検討,
第43回日本心臓病学会, 1995年9月. 山田博胤, 大木崇, 井内新, 田畑智継, 真鍋和代, 影治好美, 佐々木美和, 福田信夫 :
健常者における左室局所壁運動速度の評価:組織ドプラ法を用いた検討,
第43回日本心臓病学会, 1995年9月. 田畑智継, 大木崇, 井内新, 真鍋和代, 影治好美, 佐々木美和, 山田博胤, 福田信夫 :
肥大心における左室壁運動異常の評価:組織ドプラ法による検討,
第43回日本心臓病学会, 1995年9月. 田畑智継, 大木崇, 福田信夫, 井内新, 佐々木美和, 山田博胤, 西角彰良, 若槻哲三, 篠原尚典, 酒部宏一 :
組織ドプラ法を用いた左室弛緩異常の評価:左室圧下降脚時定数との比較,
第43回日本心臓病学会, 1995年9月. 福田信夫, 大木崇, 井内新, 田畑智継, 佐々木美和, 山田博胤, 西角彰良, 若槻哲三, 篠原尚典, 酒部宏一 :
拡張早期左室流入血流伝播速度の臨床的意義の再検討:左室圧下降脚時定数および僧帽弁開放速度との関係,
第43回日本心臓病学会, 1995年9月. 山田博胤, 大木崇, 井内新, 田畑智継, 真鍋和代, 影治好美, 佐々木美和, 福田信夫 :
肺静脈および僧帽弁口血流速波形を用いた僧帽弁狭窄における左房のsystolic performanceに関する検討,
第43回日本心臓病学会, 1995年9月. 佐々木美和, 大木崇, 井内新, 田畑智継, 影治好美, 真鍋和代, 山田博胤, 福田信夫, 伊東進 :
肥大型心筋症における左房のsystolic performance:特にafterload mismatchとの関連において,
第43回日本心臓病学会, 1995年9月. 山田博胤, 大木崇, 井内新, 田畑智継, 真鍋和代, 佐々木美和, 伊東進, 福田信夫 :
拡張相に移行した肥大型心筋症の一例,
第2回中四国心筋症研究会, 1995年9月. 井内新, 大木崇, 田畑智継, 真鍋和代, 影治好美, 佐々木美和, 山田博胤, 福田信夫, 伊東進 :
洞調律の各種心筋疾患の左心耳内血流に及ぼす左房圧の影響に関する検討,
第3回体腔内心血管エコー研究会, 1995年8月. 井内新, 大木崇, 田畑智継, 山田博胤, 真鍋和代, 佐々木美和, 福田信夫, 伊東進 :
心筋梗塞における左心腔内血流動態の評価:左心系コントラストエコー法による検討,
第10回コントラストエコー研究会, 1995年8月. 山田博胤, 大木崇, 福田信夫, 井内新, 西角彰良, 野村昌弘, 田畑智継, 生藤博行, 若槻哲三, 篠原尚典, 佐々木美和, 岸史子, 酒部宏一, 伊東進 :
興味ある血行動態を示した心室中部肥大型閉塞性心筋症の一例,
第14回心脈管研究会, 1995年7月. 井内新, 大木崇, 福田信夫, 田畑智継, 真鍋和代, 影治好美, 佐々木美和, 山田博胤, 伊東進 :
心房粗細動時における左心耳内血流速波形の鋸歯状波形の成因に関する検討,
第65回日本超音波医学会, 1995年5月. 山田博胤, 大木崇, 井内新, 田畑智継, 真鍋和代, 影治好美, 佐々木美和, 福田信夫, 伊東進 :
右室流入路狭窄をきたした転移性悪性黒色腫の1例,
第65回日本超音波医学会, 1995年5月. 佐々木美和, 大木崇, 井内新, 田畑智継, 影治好美, 真鍋和代, 山田博胤, 福田信夫, 伊東進 :
肥大型心筋症における左房のsystolic performance:特にafterload mismatchとの関連において,
第65回日本超音波医学会, 1995年5月. 田畑智継, 大木崇, 井内新, 真鍋和代, 影治好美, 佐々木美和, 山田博胤, 福田信夫, 濱美紀, 伊東進 :
各種心筋疾患の洞調律時における左心耳内血流速波形の検討:特に左房圧の影響について,
第65回日本超音波医学会, 1995年5月. 井内新, 大木崇, 福田信夫, 田畑智継, 真鍋和代, 影治好美, 佐々木美和, 山田博胤, 伊東進 :
肺静脈および僧帽弁口血流速波形を用いた左心不全例における左房挙動に関する検討,
第92回日本内科学会総会, 1995年4月. 影治好美, 大木崇, 井内新, 田畑智継, 真鍋和代, 佐々木美和, 山田博胤, 福田信夫, 伊東進 :
肥大型心筋症における左房systolic performanceの評価．特にafterload mismatchとの関連において,
第59回日本循環器学会総会, 1995年4月. 田畑智継, 大木崇, 井内新, 真鍋和代, 影治好美, 佐々木美和, 山田博胤, 福田信夫, 伊東進 :
洞調律例における左心耳内血流速波形に関する検討．特に加齢による変化について,
第59回日本循環器学会総会, 1995年4月. 井内新, 大木崇, 福田信夫, 田畑智継, 真鍋和代, 影治好美, 佐々木美和, 山田博胤, 伊東進 :
心筋梗塞における左心腔内血流動態の評価．左心系コントラストエコー法による検討,
第59回日本循環器学会総会, 1995年4月. 佐々木美和, 大木崇, 福田信夫, 井内新, 田畑智継, 真鍋和代, 影治好美, 山田博胤, 伊東進 :
経胸壁および経食道Mモード法による心房収縮期の左房容積変化計測の妥当性:心房中核，僧帽弁輪運動，大動脈後壁からの検討,
第59回日本循環器学会総会, 1995年4月.

研究会・報告書

相原弘幸, 坂東遼, 松本遼太, 曽我部公子, Zheng Robert, 髙橋智紀, 西條良仁, 原知也, 門田宗之, 川端豊, 上野理絵, 松浦朋美, 伊勢孝之, 山口浩司, 八木秀介, 山田博胤, 添木武, 若槻哲三, 藤井志朗, 秦広樹, 佐田政隆 :
学生・研修医セッション1(冠動脈)血友病A患者における重症三枝病変に対する冠動脈バイパス術の一例,
第125回日本循環器学会四国地方会, 2024年12月. 伊藤直司, 西條良仁, 手束一貴, 高橋智子, 谷彰浩, 坂東遼, ロバートゼング, 髙橋智紀, 門田宗之, 川端豊, 上野理絵, 原知也, 松浦朋美, 伊勢孝之, 山口浩司, 八木秀介, 山田博胤, 添木武, 若槻哲三, 松本遼太, 秦広樹, 佐田政隆 :
ポスタ-セッション健康診断を契機に発見された巨大冠動脈瘤の一例,
第269回徳島医学会学術集会, 2024年7月. 生田航大, 芥川正武, 榎本崇宏, 木内陽介, 北岡和義, 山田博胤, 田中弘之 :
CNNを用いた総頸動脈血流速度スペクトログラムの特徴解析と動脈硬化症との関連性について,
電子情報通信学会技術研究報告(MEとバイオサイバネティックス), Vol.124, No.137, 1-5, 2024年7月.

(要約): 厚生労働省によれば日本国内における死亡原因の約22%は，循環器系疾患であることが報告されている．そこで本研究グループでは，循環器系の血行動態を調べる簡便なスクリーニングデバイスとして，頸動脈血流速度測定装置の開発に取り組んでいる．本研究では，動脈硬化症の進行度を評価判定することを目標に，頸動脈血流速度測定装置の試作機で測定された健常者と動脈硬化症患者の総頸動脈血流速度スペクトログラムを学習データとしてCNNを用い，健常者と動脈硬化症患者に分類した．また，Glad-CAMを用いて動脈硬化症患者と健常者の血流速度スペクトログラムの相違点を抽出し，比較を行った．その結果，動脈硬化症患者と健常者の分類における重要な部分に相違点があった．

松木勇樹, 芥川正武, 榎本崇宏, 北岡和義, 田中弘之, 山田博胤, 木内陽介 :
オートエンコーダを用いた頸動脈血流速度波形の特徴量と動脈硬化症の関連性に関する研究,
電子情報通信学会技術研究報告(MEとバイオサイバネティックス), Vol.122, No.424, 33-37, 2023年3月.

(要約): 近年，日本国内における死亡原因の約25%は脳梗塞，心疾患などの循環器系疾患であることが厚生労働省より報告されている．本研究グループでは循環器系の血行動態を調べる簡便なスクリーニングデバイスとして，頸動脈血流速度測定装置(UDBV，Ultrasonic Doppler Blood Velocimeter)の開発に取り組んでいる．これまで，運動効果や加齢による波形の違いが現れることが解明されてきた．しかし，動脈硬化と血流速度波形の関連性は十分に明らかではない．そこで，本研究では動脈硬化症の進行度を評価判定することを目標に，動脈硬化症患者と健常者を対象として，総頸動脈の血流速度波形の比較を行った．その結果からオートエンコーダで得られた特徴量が動脈硬化の進行度を評価できる指標である可能性が示唆された．
(キーワード): 血流速度 / 頸動脈 (carotid artery) / 動脈硬化 (atherosclerosis) / オートエンコーダ

村上貴寛, 八木秀介, 原知也, 伊勢孝之, 楠瀬賢也, 松浦朋美, 飛梅威, 山口浩司, 山田博胤, 添木武, 若槻哲三, 島袋充生, 赤池雅史, 春藤譲治, 佐田政隆 :
原発性アルドステロン症の診断に有用な臨床所見の検討,
第253回徳島医学会学術集会(平成28年度夏期), 2016年7月. 山上圭, 西條良仁, 楠瀬賢也, 山田博胤, 瀬野弘光, 原知也, 上野理絵, 門田宗之, 齋藤友子, 山﨑宙, 坂東左知子, 伊藤浩敬, 轟貴史, 松浦朋美, 伊勢孝之, 飛梅威, 山口浩司, 八木秀介, 添木武, 若槻哲三, 佐田政隆 :
生体腎移植後における腎静脈-外腸骨静脈間の血流動態変化が一因と考えられた深部静脈血栓症の一例,
第253回徳島医学会学術集会(平成28年度夏期), 2016年7月. 瀬野弘光, 楠瀬賢也, 西條良仁, 平田有紀奈, 鳥居裕太, 西尾進, 林修司, 山田博胤, 佐田政隆 :
右室ストレインはベンダー間で異なるか:3D-RVEFとの比較,
第1回関西リサーチクラブ, 2015年12月. 山田博胤, 小田代敬太, 和田靖明, 三木俊 :
症候から見た心血管病の診療:心血管エコー検査を活かす∼ミニエコー淡路∼,
第5回Kyushu心血管エコーセミナー, 2015年11月. 山田博胤, 和田靖明, 旭朝弘 :
心・血管エコー検査入門「はじめての心・血管エコー検査」,
第5回Kyushu心血管エコーセミナー, 2015年11月. 山田博胤 :
心不全の診断,
エコー淡路2015, 2015年11月. 山田博胤 :
拡張期学のヒストリー,
エコー淡路2015, 2015年11月. 山田博胤, 西條良仁 :
ちょいあてエコー検査を用いた肺血栓塞栓症の診断∼Point-of-Care Echocardiographyの実践∼,
徳島血栓塞栓性疾患研究会, 2015年10月. 山田博胤 :
経食道心エコー(TEE).技師必見:三次元の解剖(心臓の周囲も含めて),
日本心エコー図学会第12回秋期講習会, 2015年10月. 山田博胤 :
心エコー検査で分かること∼研修医のエチケット∼,
那覇市立病院エコー合宿, 2015年9月. 山田博胤 :
降圧利尿薬をどう使うか,
第7回徳島Vascular Imaging研究会, 2015年9月. 山田博胤, 横井靖世 :
生活習慣病の診療に活かす．頸動脈エコー検査:レクチャーとライブデモ,
東芝メディカルULセミナー2015 in 香川, 2015年8月. 山田博胤 :
救急外来における心エコー検査,
鈴鹿心エコー勉強会, 2015年8月. 楠瀬賢也, 山田博胤, 西尾進, 平田有紀奈, 坂東美佳, 西條良仁, 林修司, 鳥居裕太, 天野里江, 山尾雅美, 岸潤, 佐田政隆 :
膠原病に伴う肺高血圧症の進展予測:6分間歩行負荷心エコー図検査を用いた検討,
第13回先進心血管エコー研究会, 2015年8月. 山下雄也, 坂東美佳, 伊勢孝之, 楠瀬賢也, 山田博胤, 原知也, 高島啓, 山﨑宙, 斎藤友子, 坂東左知子, 飛梅威, 山口浩司, 八木秀介, 添木武, 若槻哲三, 木下肇, 藤本鋭貴, 北川哲也, 井上洋行, 佐田政隆 :
収縮期雑音を契機に発見された成人単純型大動脈狭窄症の1例,
第251回徳島医学会学術集会, 2015年8月. 瀬野弘光, 山﨑宙, 八木秀介, 黒部裕嗣, 高森信行, 楠瀬賢也, 伊勢孝之, 山口浩司, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
急激な弁破壊を認めたメチシリン感受性表皮ブドウ球菌による感染性心内膜炎の一例,
第251回徳島医学会学術集会, 2015年8月. 山田博胤, 小田代敬太, 和田靖明, 奥田真一, 三木俊 :
『いつもの心エコー検査にもう一味加えてみよう!』∼血管エコー検査の活用法∼,
第8回せとうちエコーセミナー, 2015年8月. 山田博胤, 和田靖明, 三木俊 :
『心エコー入門講座』∼これだけは知っておきたい心エコーの活用法∼,
第8回せとうちエコーセミナー, 2015年8月. 山田博胤 :
インクレチン治療の最前線．TECOS試験を踏まえて,
徳島循環器エキスパートセミナー, 2015年7月. 山田博胤 :
弁置換術後の評価,
GE Ultrasound Summer Forum 2015, 2015年7月. 山田博胤 :
初めての心エコー検査,
研修医教育講座, 2015年7月. 山田博胤, 上松正朗 :
心エコーの疑問に答えます∼知識とテクニックを身につけて，あなたの検査をレベルアップ∼,
ステップアップエコーセミナー, 2015年7月. 山田博胤, 出雲昌樹, 八鍬恒芳 :
「心血管エコー入門」循環器疾患の診療でエコー検査を活用するために,
ステップアップエコーセミナー, 2015年7月. 山田博胤 :
「信頼される心エコー」経食道心エコー検査をマスターする,
第10回Echo Kanazawa 2015, 2015年6月. 山田博胤, 楠瀬賢也 :
膠原病における運送負荷誘発性肺高血圧症∼6分間歩行負荷心エコー検査を用いて∼,
第1回負荷心エコー図研究会, 2015年6月. 山田博胤 :
心エコードプラ法で心不全の病態を解く,
第4回今さら聞けないことをトコトン学ぶ勉強会, 2015年6月. 山田博胤 :
Discussion 2 右心不全例の所見用紙から,
The Echo Live 2015, 2015年5月. 山田博胤, 鳥居裕太 :
やってよかった血管エコー検査,
徳島循環器セミナー, 2015年4月. 山田博胤, 天野里江 :
頸動脈エコー検査を活用する循環器診療:レクチャー&ライブ,
安芸郡医師会講演会, 2015年4月. 山田博胤, 小田代敬太, 和田靖明 :
症候から見た心血管病の診療:心血管エコー検査を活かす ∼ミニエコー淡路∼,
第4回KYUSHU心血管超音波セミナー, 2015年2月. 山田博胤, 小田代敬太, 和田靖明 :
心・血管エコー検査入門,
第4回KYUSHU心血管超音波セミナー, 2015年2月. 山田博胤 :
機能を理解する:ワンポイント．心房細動の心機能評価,
日本心エコー図学会第19回冬季講習会, 2015年1月. 山田博胤 :
機能を理解する:サルでもわかる心力学,
日本心エコー図学会第19回冬季講習会, 2015年1月. 山田博胤 :
虚血以外の負荷心エコー法 ∼しない方がストレスフル?∼,
第17回北海道心血管エコー研究会, 2014年11月. 山田博胤, 川崎俊博 :
むくみの心エコー検査．右心不全心エコーライブ,
エコー淡路2014, 2014年11月. 山田博胤, 堀家由貴 :
頸動脈エコー検査を活用する循環器診療:レクチャー&ライブデモ,
東部循環器セミナー, 2014年10月. 山田博胤 :
E波とかけて恋愛と解く，その心は?心エコー・ドプラ法で診る心不全,
東芝エコーセミナー, 2014年9月. 山田博胤, 天野里江 :
歯科医が知っておきたい循環器疾患:超音波で見る動脈硬化と心臓病,
若葉会勉強会, 2014年9月. 山田博胤 :
心臓発作で倒れない!生活習慣病対策のコツ,
J-ISCP第6回市民公開講座, 2014年9月. 山田博胤 :
心エコー・ドプラ法を駆使して心源性脳梗塞の病態に迫る,
中部ネットワークミーティング, 2014年9月. 山田博胤 :
心エコー・ドプラ法で診る心不全∼E波とかけて恋愛と解く，その心は?∼,
島根大学病院循環器内科勉強会, 2014年8月. 山田博胤, 大西哲存 :
心血管エコーレクチャープログラム血管エコー検査を活用する心エコー検査のスキルアップ,
第7回瀬戸内エコーセミナー, 2014年8月. 山田博胤, 大西哲存 :
レジデントのための聴診&心エコー講座 ∼これだけは知っておきたい聴診器とエコー装置の活用法∼,
第7回瀬戸内エコーセミナー, 2014年8月. 山田博胤 :
心エコーハンズオン,
第6回四国循環器セミナー, 2014年7月. 山田博胤 :
心サルコイドーシス,
超音波診断講習会, 2014年6月. 山田博胤 :
左室収縮能の評価ライブデモンストレーション,
The Echo Live 2014, 2014年6月. 山田博胤 :
レジデントのための循環器エコー講座,
スキルアップエコーセミナー, 2014年6月. 山本伸昭, 藤田浩司, 和泉唯信, 梶龍兒, 山口泉, 里見淳一郎, 永廣信治, 山田博胤, 木下肇, 北川哲也 :
心内巨大血栓に伴う急性期脳梗塞の1例,
第16回徳島脳血管障害カンファレンス, 2014年4月. 山田博胤 :
肺高血圧症の診断と治療,
バイエル社内勉強会, 2014年4月. 山田博胤 :
冠動脈疾患の診療における頸動脈エコー検査の意義,
第12回血管不全研究会学術集会, 2014年4月. Hirotsugu Yamada and Kenya Kusunose :
Clinical application of Preload stress echocardiography.,
Cardiac Imaging Department Conference., Apr. 2014. 山田博胤, 平田有紀奈 :
歯科医に知っておいてもらいたい循環器疾患:超音波で見る動脈硬化と心臓病,
徳島大学口腔外科同門会講演会, 2014年3月. 山田博胤 :
心房細動と心原性脳塞栓症:心エコー検査に求められること,
狭山心エコー図カンファレンス, 2014年2月. 山田博胤, 西尾進 :
心エコー，血管エコーのコラボレーション,
本郷心エコーセミナー, 2014年1月. 山田博胤 :
心房細動の心機能評価,
超音波検査学会中級者講習会, 2014年1月. 山田博胤 :
症例で感じるエコー検査の力:ライブデモンストレーション,
第3回KYUSHU心血管超音波セミナー in 福岡, 2013年11月. 山田博胤 :
ERで活用する心・血管エコー法 ②急性心不全,
第3回KYUSHU心血管超音波セミナー in 福岡, 2013年11月. 松浦朋美, 飛梅威, 添木武, 坂東左知子, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 若槻哲三, 佐田政隆 :
室房ブロックを伴っても持続する2種類の房室結節リエントリー性頻拍を認め，上位共通路の存在が示唆された1例,
第25回カテーテルアブレーション委員会公開研究会, 2013年11月. 山田博胤 :
ieで診断するIE,
第1回徳島エコーサロン, 2013年10月. 山田博胤 :
糖尿病と頸動脈エコー検査,
第3回Tokushima Vascular Failure Forum, 2013年10月. 山田博胤, 西尾進 :
肺動脈性肺高血圧症(PAH)の診断∼心エコー検査を中心に∼心エコー検査ライブデモンストレーション∼肺高血圧症のみかた∼,
第425回徳島県中部臨床研究会, 2013年10月. 山田博胤, 坂東美佳, 鳥居裕太, 西尾進, 平田有紀奈 :
エコー検査を用いた深部静脈血栓症と肺塞栓症の診断法,
第6回超音波セミナー, 2013年10月. 山田博胤 :
救急外来での心不全の見方を教えてください,
心エコーステップアップセミナー心エコー検査の疑問に答えます Part2, 2013年10月. 山田博胤 :
肺静脈血流速波形の撮り方と解釈を教えてください,
心エコーステップアップセミナー心エコー検査の疑問に答えます Part2, 2013年10月. 山田博胤 :
心エコーで分かる心筋梗塞の合併症はどんなものがありますか?,
心エコーステップアップセミナー心エコー検査の疑問に答えます Part2, 2013年10月. 山田博胤 :
冠動脈の解剖について復習したいのですが,
心エコーステップアップセミナー心エコー検査の疑問に答えます Part2, 2013年10月. 山田博胤 :
大動脈弁逆流の重症度評価はどうしたらいいですか?,
心エコーステップアップセミナー心エコー検査の疑問に答えます Part2, 2013年10月. 山田博胤 :
僧帽弁狭窄症で見るできポイントは?,
心エコーステップアップセミナー心エコー検査の疑問に答えます Part2, 2013年10月. 山田博胤 :
下大動脈径はどこを測ればいいのですか?,
心エコーステップアップセミナー心エコー検査の疑問に答えます Part2, 2013年10月. 山田博胤 :
パルスドプラ法と連続波ドプラ法はどう使い分けますか?,
心エコーステップアップセミナー心エコー検査の疑問に答えます Part2, 2013年10月. 山田博胤 :
ルーチン検査で測っておくべき計測項目を教えてください,
心エコーステップアップセミナー心エコー検査の疑問に答えます Part2, 2013年10月. 山田博胤 :
周波数とか音響インピーダンスとか知らなくてもエコーはできますよね?,
心エコーステップアップセミナー心エコー検査の疑問に答えます Part2, 2013年10月. 山田博胤 :
心エコー検査のときにあったら便利な小道具は?,
心エコーステップアップセミナー心エコー検査の疑問に答えます Part2, 2013年10月. 山田博胤 :
心エコー検査の前にとっておいたほうがいい身体所見は何ですか?,
心エコーステップアップセミナー心エコー検査の疑問に答えます Part2, 2013年10月. 山田博胤 :
感染症心内膜炎の診断と手術適応,
第10回日本心エコー図学会秋期講習会, 2013年10月. 山田博胤 :
先天性心疾患患者が妊娠,
第62回徳島心エコー図研究会, 2013年10月. 山田博胤, 鳥居裕太 :
エコー検査を用いた深部静脈血栓症と肺塞栓症の診断法,
第5回超音波セミナー, 2013年9月. 山田博胤 :
深部静脈血栓症の治療,
第6回瀬戸内エコーセミナー, 2013年9月. 山田博胤 :
高血圧以外の左室肥大,
第6回瀬戸内エコーセミナー, 2013年9月. 山田博胤 :
脳外科に紹介すべき所見,
第6回瀬戸内エコーセミナー, 2013年9月. 山田博胤 :
心エコー検査でわかる動脈硬化,
第6回瀬戸内エコーセミナー, 2013年9月. 坂東美佳, 山田博胤 :
冠動脈疾患における頸動脈プラークの組織性状変化は，冠動脈プラークの組織性状変化を反映するか,
第11回先進心血管エコー研究会, 2013年8月. 平田有紀奈, 山田博胤 :
どこの脂肪が冠動脈狭窄と関連するか?,
第3回四国シンフォニー, 2013年7月. 山田博胤, 平田有紀奈 :
隠れプラークとエイリアン脂肪∼超音波検査で診る動脈硬化∼&頸動脈エコー検査のライブスキャン,
生協中国四国ブロック特別講演会, 2013年7月. 山田博胤 :
心エコー・ドプラ法を用いた心房細動の心機能評価,
第9回島根臨床心エコー図研究会, 2013年7月. Takeshi Soeki, T Matsuura, S Bando, E Uematsu, Takayuki Ise, Takeshi Tobiume, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro, I Kishimoto, Kenji Kangawa and Masataka Sata :
Ghrelin protects the heart against ischemia-induced arrhythmia by preserving connexin 43 protein.,
第36回心筋代謝研究会, Jul. 2013. 山田博胤 :
心サルコイドーシスの心エコー診断,
CORDANO研究会, 2013年6月. 山田博胤 :
Meet the Experts 2 脳塞栓・肺塞栓とその塞栓源予防治療のガイドライン,
エコーライブ大阪2013, 2013年5月. 山田博胤 :
Discussion2 不全心の原因・結果を評価する Lec3 EF維持例での拡張能評価(症例提示),
エコーライブ大阪2013, 2013年5月. 山田博胤, 平田有紀奈 :
血管診療における心エコー検査の役割,
平成25年度第1回血管無侵襲診断セミナー, 2013年5月. 山田博胤 :
心エコー法を用いた心原性塞栓症の原因と病態の究明,
第2回茨城心房細動塞栓予防研究会, 2013年4月. 山田博胤, 西尾進 :
心エコー・ドプラ法を用いた左室拡張能の評価,
Cardiovascular Echo Meeting in Yamaguchi, 2013年4月. 山田博胤 :
血管機能ガイドラインの活用 Part2 冠動脈疾患，心疾患,
第11回血管不全研究会, 2013年4月. 山田博胤 :
心不全とpreload,
神戸大学・徳島大学心エコー合宿, 2013年2月. 山田博胤, 西尾進 :
肺動脈性肺高血圧(PAH)の診断エコー検査を中心に,
海部郡医師会講演会, 2013年2月. 山田博胤 :
エコーからみた心不全∼preloadとafterloadを考慮した診断∼,
Osaka臨床検査研究会, 2013年2月. 山田博胤 :
エコーからみた心不全,
循環器談話会, 2013年1月. 山田博胤 :
運動負荷心エコー法による膠原病性肺高血圧症の早期診断,
島根肺高血圧症研究会, 2012年12月. 山田博胤 :
壁運動異常の見方,
第60回徳島心エコー図研究会, 2012年11月. 山田博胤, 西尾進 :
隠れプラークとエイリアン脂肪∼無症状のまま進行する動脈硬化をエコーで可視化する∼,
第2回徳島県臨床内科医会カンファレンス, 2012年11月. 山田博胤 :
生活習慣病の診療に生かす心・血管エコー検査ランチョンセミナー『エコーの力』心エコーと血管エコーのコラボレーション,
第2回KYUSHU心血管超音波セミナー, 2012年11月. 山田博胤 :
高血圧性心疾患左室肥大の評価法『エコーの力』心エコーと血管エコーのコラボレーション,
第2回KYUSHU心血管超音波セミナー, 2012年11月. 山田博胤 :
心・大血管エコー検査のスクリーニングとちょい当てエコー『エコーの力』心エコーと血管エコーのコラボレーション,
第2回KYUSHU心血管超音波セミナー, 2012年11月. 山田博胤, 西尾進 :
しないほうがストレスになるストレスエコー∼虚血診断だけではない負荷エコー検査の臨床応用∼,
第3回Setagaya Heart Conference, 2012年9月. 山田博胤, 中川摩耶 :
エコーで可視化するメタボリックシンドローム∼隠れプラークとエイリアン脂肪の探し方∼,
東芝社機器展示会, 2012年8月. 山田博胤, 西尾進 :
肺動脈性肺高血圧症(PAH)の診断∼心エコー検査を中心に∼心エコー検査ライブデモンストレーション∼肺高血圧症のみかた∼,
鳴門市医師会学術講演会, 2012年7月. 山田博胤 :
Case-based Lectures 心房細動の心機能評価をどうするべきか? How to Assess LV Function in Patients with Atrial Fibrillation 心不全と心機能,
第21回日本心エコー図学会夏期講習会, 2012年7月. 山田博胤, 西尾進 :
腎動脈狭窄症の超音波診断,
徳島Vascular Imaging研究会, 2012年7月. 添木武, 山田博胤, 松浦朋美, 坂東左知子, 坂東美佳, 佐田政隆 :
カテーテルアブレーションハンズオンセミナー,
第4回四国研修会, 2012年7月. 山田博胤, 岩田貴, 西尾進 :
FAST，超音波ガイド下血管アクセス,
徳島市医師会第6回学術講演会,第3回超音波セミナー, 2012年7月. 山田博胤, 桜山千恵子, 石谷晴信, 赤坂和紀 :
心エコービギナーズ・ハンズオンセミナー,
第5回心エコー道場, 2012年7月. 山田博胤 :
運動負荷心エコー法による膠原病性肺動脈性肺高血圧症の早期診断,
肺高血圧症講演会, 2012年7月. Hirotsugu Yamada :
Early diagnosis of Pulmonary Artery Hypertension by 6-minute Walk Stress Echocardiography in Patients with Connective Tissue Disease.,
9th Scientific Symposium PAH management, Jul. 2012. 山田博胤 :
運動負荷心エコー法による膠原病性肺動脈性肺高血圧症の早期診断,
倉敷肺高血圧症セミナー, 2012年6月. 山田博胤 :
脳卒中の頸動脈エコー検査,
第6回瀬戸内エコーセミナー, 2012年6月. 山田博胤 :
むくみ患者の心エコー検査,
第6回瀬戸内エコーセミナー, 2012年6月. 山田博胤 :
心筋梗塞の心エコー検査,
第6回瀬戸内エコーセミナー, 2012年6月. 山田博胤 :
生活習慣病の診療における心エコー検査の役割,
第6回瀬戸内エコーセミナー, 2012年6月. 山田博胤 :
心エコー編しないほうがストレスになるストレスエコー∼虚血診断だけではない負荷心エコー検査の臨床応用∼,
長崎心エコー研究会, 2012年6月. 山田博胤 :
DPP4阻害薬と心機能,
CORRNA研究会, 2012年6月. 山田博胤 :
その息切れは心不全?,
Echo Live Osaka 2012, 2012年5月. 山田博胤, 玉井利奈 :
見落とすと怖い頸部血管エコー最低限の知識とスキル,
生活習慣病フォーラム, 2012年3月. 坂東美佳, 山田博胤, 西尾進, 冨田紀子, 發知淳子, 林修司, 中川摩耶, 玉井利奈, 平田有紀奈, 弘田大智, 小笠原梢, 髙島啓, 山崎宙, 坂東左知子, 伊勢孝之, 仁木敏之, 山口浩司, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
質低下療法による頸動脈プラーク安定化の評価,
第5回T0kushima Young Investigators Conference, 2012年3月. 發知淳子, 山田博胤 :
膠原病性肺動脈性肺高血圧の早期診断における6分間歩行負荷心エコー検査の有用性,
肺高血圧症の診断・治療講演会, 2012年3月. 西尾進, 山田博胤 :
モノクロタリン誘発性イヌ肺高血圧モデルにおけるMモード法およびスペックストラッキング法を用いた右室収縮能の検討,
肺高血圧症の診断・治療講演会, 2012年3月. 山田博胤, 玉井利奈 :
日常臨床における頸動脈エコーの使い方∼心筋梗塞・脳卒中を減らすために∼,
第9回徳島市医師会学術講演会, 2012年3月. 山田博胤 :
ERにおける心エコーの役割(特別講演),
第18回三重超音波研究会循環器分科会, 2012年3月. 山田博胤, 山崎正之, 横井靖世 :
心エコービギナーズ・ハンズオンセミナー,
第5回心エコー道場, 2012年2月. 佐藤光代, 山田博胤 :
CAVIとbaPWVはどちらがいいか?,
第2回Vasculr Lab研究会, 2011年12月. 坂東美佳, 山田博胤, 冨田紀子, 發知淳子, 西尾進, 中川摩耶, 玉井利奈, 平田有紀奈, 弘田大智, 坂東左知子, 伊勢孝之, 仁木敏之, 山口浩司, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 佐田政隆 :
Fabry病の2家系,
第16回中四国心筋症・心不全研究会, 2011年9月. 岩瀬俊, 伊勢孝之, 小笠原梢, 山崎宙, 高島啓, 坂東左知子, 仁木敏之, 楠瀬賢也, 發知淳子, 冨田紀子, 上田由佳, 山口浩司, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 佐田政隆, 髙尾正一郎, 能勢隼人, 原田雅史, 赤池雅史, 足立克仁 :
Duchenne型筋ジストロフィー女性キャリアの心病変検出における心臓MRI検査の有用性,
第16回中四国心筋症・心不全研究会, 2011年9月. 原知也, 岩瀬俊, 高島啓, 山崎宙, 小笠原梢, 坂東左知子, 伊勢孝之, 仁木敏之, 楠瀬賢也, 上田由佳, 冨田紀子, 山口浩司, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 佐田政隆, 赤池雅史, 能勢隼人, 髙尾正一郎, 大塚秀樹, 原田雅史, 西岡安彦 :
心サルコイドーシス診断の手引きにおける各種診断モダリティーの検討,
第16回中四国心筋症・心不全研究会, 2011年9月. 林修司, 山田博胤, 楠瀬賢也, 西尾進, 發知淳子, 冨田紀子, 仁木敏之, 山口浩司, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 佐田政隆 :
高齢者の左室弛緩能に心拍数が与える影響について:僧帽弁口血流速パターンをどう解釈するか,
第1回四国symphony, 2011年7月. 楠瀬賢也, 西尾進, 山田博胤 :
不整脈と心エコー,
第19回徳島超音波研究会, 2011年5月. 清水拓, 楠瀬賢也, 山田博胤, 西尾進, 玉井利奈, 遠藤桂輔, 佐藤光代, 河野裕美, 赤池雅史, 佐田政隆 :
運動負荷心エコー法を用いた膠原病例における潜在性肺動脈性高血圧症の検出,
第2回徳島肺高血圧研究会, 2011年4月. 山田博胤 :
断層心エコーの基本，ドプラ法の基本,
第4回心エコー道場, 2011年3月. 山田博胤 :
心血行動態の評価にドプラ法を使い倒す∼本当に必要な知識とテクニック∼,
第8回京都循環器検査研究会学術集会, 2011年3月. 山田博胤 :
左室壁運動異常を診る∼ヒトの眼 vs.機械の目∼,
GE Cardiac Seminar in Hiroshima, 2011年2月. 山田博胤 :
心エコーライブデモンストレーション&セミナー,
アスリードステップアップエコーセミナー, 2011年2月. 山中森晶, 山田博胤 :
当院ストロークケアユニットにおける心原性塞栓症の現状,
第9回眉山循環器カンファレンス, 2011年2月. 林修司, 山田博胤, 楠瀬賢也, 冨田紀子, 多田津陽子, 西尾進, 玉井利奈, 岩瀬俊, 添木武, 佐田政隆 :
体位変換により右室内圧較差が変化をきたす右室二腔症の一例,
UCG談話会, 2011年1月. 山田博胤 :
A Happy New Echo!,
第45回徳島臨床カンファレンス, 2011年1月. 山田博胤 :
肺高血圧症の現状,
ヴォルボリス発売記念勉強会, 2011年1月. 山田博胤 :
心肥大を診る!2011,
阿南医師会学術講演会, 2011年1月. 遠藤桂輔, 山田博胤, 楠瀬賢也, 西尾進, 冨田紀子, 三木淳子, 林修司, 玉井利奈, 河野裕美, 平岡葉月, 佐藤光代, 山口浩司, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 赤池雅史, 齋藤憲, 佐田政隆 :
陳旧性心筋梗塞症における心電図左房負荷所見の意義:心エコー・ドプラ法を用いた検討,
心・血管クラスターミニリトリート, 2011年1月. 山田博胤 :
IMTの撮り方と循環器診療での使い方,
第1回糖尿病と血管障害を考える会, 2010年11月. 山田博胤 :
心エコーを始めるまでに,
エコー淡路2010, 2010年11月. 山田博胤 :
左室拡張能とは?,
エコー淡路2010, 2010年11月. 山田博胤 :
脂肪酸測定からみた治療戦略虚血性心疾患におけるEPAの意義,
N-3脂肪酸研究会, 2010年11月. 山田博胤 :
僧帽弁閉鎖不全症診断と手術のピットフォール,
阪神心臓弁膜症シンポジウム, 2010年10月. 西尾進, 山田博胤 :
僧帽弁逆流のいろいろ,
宮崎大学循環器グループ勉強会, 2010年9月. 山田博胤 :
左室拡張不全の病態と診断,
宮崎大学循環器グループ勉強会, 2010年9月. 楠瀬賢也, 山田博胤, 西尾進, 冨田紀子, 林修司, 三木淳子, 仁木敏之, 山口浩司, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
左室内同期不全に対する前負荷の影響拡張型心筋症における下肢陽圧負荷3次元心エコー法を用いた検討,
先進血管エコー研究会, 2010年8月. 山田博胤, 西尾進, 玉井利奈, 遠藤桂輔, 冨田紀子, 楠瀬賢也, 林修司, 竹谷善雄, 佐田政隆 :
頸動脈エコーによるプラークの超音波正常カラーイメージングの試み,
第6回西日本血管・機能研究会, 2010年8月. 山田博胤 :
心エコーの基礎，ドプラ法の基礎，心エコーハンズオン,
第3回心エコー道場, 2010年7月. 山田博胤 :
心肥大を考慮した高血圧治療,
美馬市医師会講演会, 2010年7月. 山田博胤 :
心エコー検査,
第2回四国循環器研修会, 2010年7月. 山田博胤 :
徳島大学病院Vascular Labの構想,
第1回Vascular Lab研究会, 2010年7月. 山田博胤 :
左房内血栓,
第2回徳島Vascular Imaging研究会, 2010年7月. 遠藤桂輔, 山田博胤, 西尾進, 冨田紀子, 楠瀬賢也, 林修司, 佐藤光代, 平岡葉月, 河野裕美, 三木淳子, 玉井利奈, 山口浩司, 竹谷善雄, 添木武, 若槻哲三, 赤池雅史, 佐田政隆, 齋藤憲 :
心電図異常を指摘され，心エコー検査で発見された左室緻密化障害の1例,
第3回蔵本エコーカンファレンス, 2010年7月. 山田博胤 :
ランチョンセミナー．クイズで学ぶ超音波の基礎．,
日本心エコー図学会, 2010年5月. 山田博胤 :
心エコーすべての疑問に答えます,
アスリード心エコースキルアップセミナー, 2010年3月. 山田博胤 :
おとっつぁんとおっかさん,
第4回内科スキルアップセミナー, 2010年2月. 山田博胤 :
心エコーハンズオンセッション,
麻酔集中ウルトラサウンドセミナー, 2010年2月. 山田博胤 :
心エコーハンズオン,
麻酔集中治療ウルトラサウンドセミナー, 2010年2月. 山田博胤 :
心エコー症例検討,
US-lead心エコースキルアップセミナー, 2009年10月. 山田博胤 :
心エコー検査を始めるまで,
四国循環器研修会, 2009年9月. 楠瀬賢也, 山田博胤, 西尾進, 冨田紀子, 遠藤桂輔, 仁木敏之, 山口浩司, 小柴邦彦, 八木秀介, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
心房細動におけるE/e'の計測法:dual Doppler法を用いた検討,
第8回先進血管エコー研究会, 2009年8月. 山田博胤 :
心エコーを始めるまで,
第1回循環器ブートキャンプ, 2009年7月. 山田博胤 :
虚血性心疾患と頚動脈エコー,
第1回Vascular imaging研究会, 2009年7月. 山田博胤 :
心不全の病態を心エコー・ドプラ法で考える,
さくら診療所勉強会, 2009年6月. 山田博胤 :
症例から学ぶ心機能評価,
心エコースキルアップセミナー, 2009年5月. 山田博胤 :
収縮能と拡張能の診かた,
心エコースキルアップセミナー, 2009年5月. 山田博胤 :
心エコーに役立つ聴診の仕方,
心エコースキルアップセミナー, 2009年5月. 山田博胤 :
心エコーハンズオンセミナー.,
2009年5月. 山田博胤, 西尾進 :
脇町ハンズオンセミナー,
2009年4月. 山田博胤 :
脳塞栓の原因をエコーで探る,
第43回兵庫県心エコー図カンファレンス, 2009年4月. 山田博胤 :
E/e'を斬る∼拡張能はエコーでわかる∼,
軽井沢ウインターセミナー, 2009年2月. 山田博胤 :
症例検討(腫瘍，血栓),
軽井沢ウインターセミナー, 2009年2月. 山中森晶, 山田博胤, 楠瀬賢也, 冨田紀子, 仁木敏之, 山口浩司, 小柴邦彦, 八木秀介, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆, 西尾進 :
脳卒中患者における心エコー検査の現状:徳島大学病院SCU搬送例における検討,
第11回徳島脳卒中研究会, 2009年2月. 山中森晶, 山田博胤, 楠瀬賢也, 冨田紀子, 仁木敏之, 山口浩司, 小柴邦彦, 八木秀介, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆, 西尾進 :
脳卒中患者における心エコー検査の現状:徳島大学病院SCU搬送例における検討,
脳卒中研究会, 2009年2月. 山田博胤 :
新機能を臨床にどう活かすか．AFIの撮り方，使い方,
第11回エコーウインターセミナー, 2009年2月. 山田博胤 :
血栓，腫瘍,
第11回エコーウインターセミナー, 2009年2月. 山田博胤 :
拡張機能評価E'を斬る!エコーで拡張能は分かる,
第11回エコーウインターセミナー, 2009年2月. 山田博胤 :
脳塞栓の原因をエコーで探す,
SCU勉強会, 2009年1月. 山田博胤 :
心エコー・FAST,
麻酔集中治療ウルトラサウンドセミナー, 2009年1月. 西尾進, 笹田倫子, 平田有紀奈, 鳥居裕太, 山尾雅美, 山田博胤, 土井俊夫, 佐田政隆 :
推算糸球体濾過量 (eGFR) と関連する腎エコー検査指標について,
超音波検査技術, Vol.41, No.0, S201, 2016年6月. 平田有紀奈, 山田博胤, 楠瀬賢也, 鈴川理乃, 衣川尚知, 鳥居裕太, 天野里江, 山尾雅美, 西尾進, 瀬野弘光, 西條良仁, 佐田政隆 :
心外膜下脂肪厚は虚血性心疾患の壁運動回復の有無を反映する,
超音波検査技術, Vol.41, No.0, S158, 2016年6月. 長瀬襟加, 鳥居裕太, 西尾進, 平田有紀奈, 山尾雅美, 岩本誠司, 山田博胤, 六車直樹, 佐田政隆 :
好酸球性胆管炎の1例,
超音波検査技術, Vol.41, No.1, 128, 2016年2月. 長瀬襟加, 鳥居裕太, 西尾進, 松本力三, 平田有紀奈, 山尾雅美, 中野万有里, 岩本誠司, 髙尾正一郎, 山田博胤, 佐田政隆 :
重複下大静脈に血栓を認めた1例,
超音波検査技術, Vol.41, No.5, 584, 2016年. 鳥居裕太, 西尾進, 鈴川理乃, 平田有紀奈, 天野里江, 山尾雅美, 坂東美佳, 木下肇, 髙尾正一郎, 楠瀬賢也, 山田博胤, 佐田政隆 :
感染性心内膜炎が契機となった右脛骨腓骨動脈感染性動脈瘤の1例,
超音波検査技術, Vol.40, No.suppl, S158, 2015年5月. 平田有紀奈, 山田博胤, 西尾進, 堀家由貴, 玉井佑里恵, 鳥居裕太, 天野里江, 山尾雅美, 坂東美佳, 林修司, 楠瀬賢也, 佐田政隆 :
肺高血圧を伴う右肺動脈上行大動脈起始の1例,
超音波検査技術, Vol.40, No.1, 85, 2015年3月. 武内早苗, 早渕純子, 山田博胤, 西尾よしみ, 横山小百合, 西田洋子, 井﨑ゆみ子, 前田健一, 大森哲郎 :
徳島大学職員への頸動脈エコー実施の試み,
第44回中国四国大学保健管理研究集会報告書, 76-80, 島根, 2014年.

特許: 佐田政隆, 山田博胤 : 超音波エコーによる頚動脈プラークの性状判定方法, 特許第2010-73153号. 佐田政隆, 山田博胤, 楠瀬賢也, 發知淳子 : 起立性調節障害の治療用加圧装置, (2014年2月), (2014年8月), 特許第PCT/JP2014/054779号. 佐田政隆, 山田博胤, 發知淳子 : 体位性頻脈症候群の治療用加圧装置, (2014年1月), 特許第2014-009175号 (2014年1月). 佐田政隆, 山田博胤 : 頸動脈プラークのエコー画像生成方法及び評価, (2011年1月), 特許第2012-506873号 (2015年6月). 佐田政隆, 山田博胤 : 頸動脈プラークのエコー画像生成方法及び評価装置, (2011年1月), (2011年9月), 特許第5765823号 (2015年6月).
作品: 八木秀介, 福田大受, 平田有紀奈, GANBAATAR BYAMBASUREN, Arief Rahadian, 伊勢孝之, 楠瀬賢也, 山田博胤, 山口浩司, 松浦朋美, 飛梅威, 曽我朋宏, 添木武, 若槻哲三, 川人伸次, 佐田政隆 :
【糖尿病専門医に必要な心不全の知識update】SGLT2阻害薬と心不全(解説/特集),
糖尿病・内分泌代謝科, Vol.52, No.3, 257-264, 2021年11月. 森田沙瑛, 西尾進, 平田有紀奈, 山口夏美, 湯浅麻美, 松本力三, 山尾雅美, 荒瀬美晴, 楠瀬賢也, 山田博胤, 佐田政隆 :
ハイエンド汎用超音波診断装置(LOGIQ E10)と循環器専用超音波診断装置(Vvid E95)におけるglobal longitudinal strainの装置間差に関する検討,
超音波検査技術, Vol.46, No.5, 463-470, 2021年11月.
補助金・競争的資金: 慢性心不全患者における下肢陽圧負荷心エコー法の臨床応用 (研究課題/領域番号: 17K01412 )
膠原病における潜在性肺高血圧症に対する早期治療介入の有用性 (研究課題/領域番号: 17K09506 )
iPlaqueを用いた頸動脈プラークの性状評価による動脈硬化疾患の予後予測 (研究課題/領域番号: 16K01412 )
潜在性肺高血圧症の非侵襲的診断法の確立と臨床的特徴 (研究課題/領域番号: 23591047 )
慢性心不全における下肢陽圧負荷心エコー法の臨床的有用性の確立 (研究課題/領域番号: 22500437 )
下半身陽圧負荷心エコーによる左房-左室連関に関する検討 (研究課題/領域番号: 18700439 )
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専門分野・研究分野: 医学 (Medicine)
所属学会・所属協会: 日本心エコー図学会
日本超音波医学会
社団法人日本循環器学会
委員歴・役員歴: 日本心エコー図学会 (評議員 [2005年〜2014年])
日本超音波医学会 (四国地方会運営委員 [2005年〜2014年])
社団法人日本循環器学会 (中国・四国地方会評議員 [2008年〜2020年3月])
日本超音波医学会 (代議員 [2011年〜2020年])
日本心エコー図学会 (理事 [2020年4月])
受賞: 1992年, 三木康楽賞 (三木康楽会)
2004年, Abstract Award in NASPE Heart Rhythm Society (NASPE)
2007年4月, 日本心エコー図学会学術集会Young Investigator's Aword (日本心エコー図学会)
2010年5月, 第11回日本超音波医学会奨励賞 (社団法人日本超音波医学会)
2013年1月, 公益財団法人康樂會賞 (公益財団法人康樂會)
2013年1月, 公益財團法人康樂會賞 (財団法人三木康楽会)
2013年4月, 第24回日本心エコー図学会学術集会海外学会発表優秀論文賞 (日本心エコー図学会)
2013年5月, 第102回日本循環器学会中国・四国合同地方会研修医部門最優秀賞 (社団法人日本循環器学会)
2013年5月, 第102回日本循環器学会中国・四国合同地方会コメディカル部門最優秀賞 (社団法人日本循環器学会)
2013年8月, ESC Congress 2013 The Top Score Poster Award (European Society of Cardiology)
2013年10月, 日本超音波医学会第23回四国地方学術集会 The Best Imaging賞 (日本超音波医学会)
2013年12月, 第103回日本循環器学会四国地方会コメディカルセッション奨励賞 (社団法人日本循環器学会)
2013年12月, 第103回日本循環器学会四国地方会学生・研修医セッション奨励賞 (社団法人日本循環器学会)
2014年4月, 第25回日本心エコー図学会学術集会ベストポスター賞 (日本心エコー図学会)
2014年4月, 第25回日本心エコー図学会学術集会一般口演優秀賞 (日本心エコー図学会)
2014年7月, 第248回徳島医学会学術集会(平成25年度冬期)若手奨励賞 (徳島医学会)
2014年7月, 第248回徳島医学会学術集会(平成25年度冬期) 若手奨励賞 (徳島医学会)
2014年9月, 第62回日本心臓病学会学術集会優秀賞(優秀演題セッション口演1 一般) (日本心臓病学会)
2014年10月, 第24回日本超音波医学会四国地方会学術集会 The Best Imaging 優秀発表賞(心血管) (日本超音波医学会)
2014年12月, 第105回日本循環器学会四国地方会コメディカルセッション奨励賞 (社団法人日本循環器学会)
2015年3月, 平成26年度表彰論文優秀賞 (公益財団法人福田記念医療技術振興財団)
2015年9月, 第63回日本心臓病学会学術集会若手症例Presenter賞 (日本心臓病学会)
2016年3月, 第5回日本循環器学会循環器臨床研究奨励賞(症例報告部門) (社団法人日本循環器学会)
2016年3月, 第3回日本循環器学会循環器イメージング賞 (社団法人日本循環器学会)
2016年5月, 第89回学術集会第17回奨励賞 (日本超音波医学会)
2016年6月, 第108回日本循環器学会中国・四国合同地方会「研修医奨励賞」 (日本心臓病学会)
2016年7月, 第253回徳島医学会学術集会(平成28年度夏期)「若手奨励賞」 (徳島医学会)
2016年9月, 第64回日本心臓病学会学術集会優秀演題セッション(医師部門)優秀賞 (日本心臓病学会)
2016年9月, KSC2016 Young Investigator's Award (The 60th Annual Scientific Meeting of The Korean Society of Cardiology)
2016年10月, 第26回四国地方会学術集会「The Best Imaging 最優秀賞」 (日本超音波医学会)
2016年12月, 第109回日本循環器学会四国地方会学生・研修医奨励賞 (社団法人日本循環器学会)
2017年3月, Young Investigator's Award (Clinical Research ) (社団法人日本循環器学会)
2017年4月, 第28回学術集会YOUNG INVESTIGATOR'S AWARD 最優秀賞 (日本心エコー図学会)
2017年6月, 第42回日本超音波検査学会学術集会YIA (日本超音波検査学会)
2017年9月, Young Investigators Award 最優秀賞 (第65回日本心臓病学会学術集会)
2018年6月, 研修医奨励賞 (第112回日本循環器学会中国・四国合同地方会)
2021年12月, 若手研究奨励賞 (第119回日本循環器学会四国地方会若手研究奨励賞)
活動: 超音波センター副センター長 (2006年4月〜2021年4月)
臨床研究倫理審査委員会委員 (2015年10月〜2017年10月)

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Ｊグローバル

Jグローバル最終確認日: 2024/12/21 01:30
氏名（漢字）: 山田博胤
氏名（フリガナ）: ヤマダヒロツグ
氏名（英字）: Yamada Hirotsugu
所属機関: 徳島大学大学院医歯薬学研究部特任教授
高松市立みんなの病院非常勤医師

リサーチマップ

researchmap最終確認日: 2024/12/22 02:44
氏名（漢字）: 山田博胤
氏名（フリガナ）: ヤマダヒロツグ
氏名（英字）: Yamada Hirotsugu
プロフィール: 1994年徳島大学医学部医学科卒．医学博士．日本超音波医学会超音波専門医，指導医．
平成6年，徳島大学医学部を卒業後，徳島大学医学部第二内科に入局，大木崇氏(独立行政法人東徳島医療センター名誉院長)に師事し，心エコー図学，特に“拡張期学”を学ぶ．平成13年から3年4ヵ月間，米国クリーブランドクリニックに留学し，Dr. James D. Thomasのラボで心エコー法の新手法，心房細動に対するペーシング療法などの研究，開発を行う．帰国後，徳島大学病院循環器内科，キャリア形成支援センター講師を経て，平成29年11月から，地域循環器内科学分野特任教授に就任した．
地域循環器内科学分野は，高松市の寄付により設立された新しい講座で，山田と坂東美佳特任助教の2人が交代で高松市民病院の循環器内科で勤務しつつ，徳島大学病院でも診療，研究，教育を続けている．高松市民病院は，平成30年9月1日に新築移転し，「高松市立みんなの病院」として再出発した．
大学病院で，心・血管エコー道場，くらもとエコー塾などを開催し，若手医師や技師に超音波検査を啓蒙する一方，エコー淡路，瀬戸内エコーセミナー，KYUSHU心血管超音波セミナーなど，全国各地で心・血管エコー検査のセミナーを企画運営しており，心・血管エコー図検査の普及に力を入れている．平成27年1月から徳島大学病院の初期研修プログラムに超音波センター研修（１～２か月）を開設したところ，希望者が殺到している．
研究では，組織ドプラ法の黎明期からその臨床応用について，特に本法を利用した左室拡張評価を主テーマとして臨床研究を継続している．また，佐田政隆教授の影響で，頸動脈プラークの性状診断や心臓周囲脂肪関連の研究も行う．肺高血圧外来，腫瘍循環器外来を担当し，膠原病性肺高血圧症に対する運動負荷心エコー図法や，がん治療に伴う心毒性の早期診断などに興味を持っている．
来年は，日本循環器学会中国・四国地方会（6月8－9日，高松）の会長，第6回Point-of-care研究会の当番世話人，第125回UCG談話会の当番世話人となり，各学会，研究会を開催する予定である．
心エコー図の研究を始めたのは，実は自身が僧帽弁逸脱症(Barlow’s disease)であり経過観察を要したためなのだが，予期せず平成28年2月に感染性心内膜炎を発症し，疣腫摘出術，僧帽弁形成術，メイズ手術を受けた．平成30年2月，突発性難聴に対するステロイド治療を契機に感染性心内膜炎が再発したが，抗生剤の投与のみで完治．何とか生き永らえている．
登録日時: 2018/11/1 10:27
更新日時: 2024/11/17 13:01
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所属: 徳島大学大学院医歯薬学研究部
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2024年12月21日更新

研究者番号: 40380084

所属（現在）: 2024/4/1 : 徳島大学, 大学院医歯薬学研究部(医学域), 特任教授

所属（過去の研究課題 情報に基づく）*注記: 2021/4/1 : 徳島大学, 大学院医歯薬学研究部(医学域), 特任教授
2018/4/1 – 2019/4/1 : 徳島大学, 大学院医歯薬学研究部(医学域), 特任教授
2017/4/1 : 徳島大学, 大学院医歯薬学研究部(医学系), 特任教授
2016/4/1 : 徳島大学, 病院, 講師
2012/4/1 – 2013/4/1 : 徳島大学, 大学病院, 講師
2010/4/1 – 2011/4/1 : 徳島大学, 病院, 講師
2007/4/1 : 徳島大学, 医学部・歯学部附属病院, 助教
2006/4/1 : 徳島大学, 医学部・歯学部附属病院, 助手

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研究代表者

総合・新領域系 / 総合領域 / 人間医工学 / 医用システム
総合系 / 複合領域 / 人間医工学 / 医用システム

研究代表者以外

生物系 / 医歯薬学 / 内科系臨床医学 / 循環器内科学
総合系 / 複合領域 / 人間医工学 / 医用システム

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研究代表者

心臓超音波検査 / 心機能 / 前負荷 / 下半身陽圧負荷 / 左室拡張能 / 左房機能 / 心房細動 / 心エコードプラ法 / 慢性心不全 / 僧帽弁口血流速波形 / 左室拡張末期圧 / 左室拡張不全 / 予後 / 下肢陽圧負荷心エコー検査 / 心不全 / 心エコー・ドプラ法 / 負荷検査 / 下肢陽圧負荷 / 脳梗塞 / 頸動脈プラーク / 超音波組織診断 / プラーク脆弱性 / 脳卒中 / 超音波検査 / 超音波組織性状 / iPlaque / 動脈硬化 / 組織性状評価 / 頸動脈硬化症 / 頸動脈超音波検査 / 心血管イベント / 不安定プラーク / 超音波診断装置 / 組織性状 / 動脈硬化疾患

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肺高血圧症 / 心臓超音波検査 / 組織ドプラ法 / 心不全 / 心エコー / 下肢陽圧 / リスク層別化 / 血行動態 / 予後 / HFpEF / 大動脈弁狭窄症 / 左室拡張能 / 左房機能 / 医用超音波システム / 臨床心臓学 / 肺高血圧 / 膠原病 / 心エコー図検査 / 運動負荷 / 内科 / 循環器 / 画像診断

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山田 博胤

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