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藤田浩司

徳島大学

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2024年11月15日更新

職名: 講師
電話: 研究者総覧に該当データはありませんでした。
電子メール: kfujita@tokushima-u.ac.jp
学歴: ????/??: 徳島大学大学院医科学教育部博士課程臨床神経科学分野/疾患酵素学研究センター ( - 2011. 3.)
1996/4: 徳島大学医学部医学科 ( - 2002. 3.)
学位: 博士(医学) (徳島大学) (2011年3月)
職歴・経歴: 〜: 徳島大学医員, 病院 (-2007.5.)
2009/6: 徳島大学ティーチング・アシスタント, 医学部 (-2010.3.)
2010/4: 徳島大学医員, 病院 (-2012.3.)
2012/4: 徳島大学特任助教, 病院 (-2012.7.)
2012/8: 徳島大学助教, 大学院ヘルスバイオサイエンス研究部 (-2015.3.)
2015/4: 徳島大学助教, 大学院医歯薬学研究部 (-2017.9.)
2018/4: 徳島大学特任助教, 病院 (-2020.3.)
2020/4: 徳島大学特任講師, 病院 (-2021.4.)
2021/5: 徳島大学講師, 大学院医歯薬学研究部

専門分野・研究分野: ライフサイエンス (Life sciences) [神経科学一般 (Neuroscience - general)]
ライフサイエンス (Life sciences) [神経内科学 (Neurology)]

研究者総覧で最新データを確認する

2024年11月15日更新

専門分野・研究分野: ライフサイエンス (Life sciences) [神経科学一般 (Neuroscience - general)]
ライフサイエンス (Life sciences) [神経内科学 (Neurology)]
担当経験のある授業科目: 神経・精神・行動コース (学部)
指導経験: 研究者総覧に該当データはありませんでした。

研究者総覧で最新データを確認する

2024年11月15日更新

専門分野・研究分野: ライフサイエンス (Life sciences) [神経科学一般 (Neuroscience - general)]
ライフサイエンス (Life sciences) [神経内科学 (Neurology)]

研究テーマ: 研究者総覧に該当データはありませんでした。

著書

原田雅史, 里見淳一郎, 藤田浩司, 山本信昭, 阿部考志 :
脳・脊髄の画像診断 ''鑑別診断力"を磨く厳選22題: 専門医試験の画像問題に自信がもてる!,
株式会社メディカ出版, 大阪, 2016年4月. 鹿草宏, 溝渕佳史, 中島公平, 藤田浩司, 阿部考志, 影治照喜, 里見淳一郎, 永廣信治, 山本伸昭 :
眼科内腫瘍性病変,
2015年7月. 武内俊明, 宮本亮介, 大崎裕亮, 阿部考志, 山本伸昭, 藤田浩司, 梶龍兒 :
中脳黒質におけるT1強調画像高信号,
株式会社メディカ出版, 大阪市淀川区宮原3-4-30, 2015年6月. 山本伸昭, 宮城愛, 藤田浩司, 阿部考志, 里見淳一郎, 梶龍兒 :
亜急性に経過した基底核・脳幹部病変,
2015年5月. 宮城愛, 山本伸昭, 藤田浩司, 阿部考志, 寺澤由佳, 梶龍兒 :
大脳半球に多発するT2*強調画像の点状低信号,
2015年2月. 山本伸昭, 宮城愛, 藤田浩司, 阿部考志, 梶龍兒 :
T1強調画像における基底核高信号,
2014年6月.

論文

Kenta Hanada, Yusuke Osaki, Koji Fujita, Tatsuya Fukumoto, Koji Fukushima, Hideki Kito and Yuishin Izumi :
Segmental Zoster Paresis Accompanied by Horner's Syndrome.,
Internal Medicine, Vol.62, No.18, 2743-2746, 2023.

(要約): We herein report a 90-year-old immunocompromised woman who developed right upper limb weakness and right ptosis with a miotic pupil 1 week after oral therapy for zoster on the right T2 dermatome. The right pupil was dilated with instillation of 1% apraclonidine, indicating Horner's syndrome. The patient was treated with intravenous acyclovir and methylprednisolone. Focal weakness related to zoster, generally known as segmental zoster paresis, improved over five months, but Horner's syndrome remained. We suggest that aggressive intravenous treatment should be considered for rare cases of zoster that occur with a combination of these two neurological conditions.
(キーワード): Aged, 80 and over / Female / Humans / Acyclovir / Blepharoptosis / Herpes Zoster / Horner Syndrome / Paresis
(徳島大学機関リポジトリ): ● Metadata: 119241
(出版サイトへのリンク): ● Publication site (DOI): 10.2169/internalmedicine.0578-22
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37722924; ● Search Scopus @ Elsevier (PMID): 37722924; ● Search Scopus @ Elsevier (DOI): 10.2169/internalmedicine.0578-22

(徳島大学機関リポジトリ: 119241, DOI: 10.2169/internalmedicine.0578-22, PubMed: 37722924) An Vo, Nha Nguyen, Koji Fujita, A Katharina Schindlbeck, Andrea Rommal, B Susan Bressman, Martin Niethammer and David Eidelberg :
Disordered network structure and function in dystonia: pathological connectivity vs. adaptive responses.,
Cerebral Cortex, Vol.33, No.11, 6943-6958, 2023.

(要約): Primary dystonia is thought to emerge through abnormal functional relationships between basal ganglia and cerebellar motor circuits. These interactions may differ across disease subtypes and provide a novel biomarker for diagnosis and treatment. Using a network mapping algorithm based on resting-state functional MRI (rs-fMRI), a method that is readily implemented on conventional MRI scanners, we identified similar disease topographies in hereditary dystonia associated with the DYT1 or DYT6 mutations and in sporadic patients lacking these mutations. Both networks were characterized by contributions from the basal ganglia, cerebellum, thalamus, sensorimotor areas, as well as cortical association regions. Expression levels for the two networks were elevated in hereditary and sporadic dystonia, and in non-manifesting carriers of dystonia mutations. Nonetheless, the distribution of abnormal functional connections differed across groups, as did metrics of network organization and efficiency in key modules. Despite these differences, network expression correlated with dystonia motor ratings, significantly improving the accuracy of predictions based on thalamocortical tract integrity obtained with diffusion tensor MRI (DTI). Thus, in addition to providing unique information regarding the anatomy of abnormal brain circuits, rs-fMRI functional networks may provide a widely accessible method to help in the objective evaluation of new treatments for this disorder.
(キーワード): Humans / Dystonia / Neural Pathways / Dystonic Disorders / 小脳 (cerebellum) / Basal Ganglia / 磁気共鳴映像法 (magnetic resonance imaging)
(出版サイトへのリンク): ● Publication site (DOI): 10.1093/cercor/bhad012
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36749014; ● Search Scopus @ Elsevier (PMID): 36749014; ● Search Scopus @ Elsevier (DOI): 10.1093/cercor/bhad012

(DOI: 10.1093/cercor/bhad012, PubMed: 36749014) Shotaro Haji, Koji Fujita, Ryosuke Oki, Yusuke Osaki, Ryosuke Miyamoto, Hiroyuki Morino, Seiichi Nagano, Naoki Atsuta, Yuki Kanazawa, Yuki Matsumoto, Atsuko Arisawa, Hisashi Kawai, Yasutaka Sato, Satoshi Sakaguchi, Kenta Yagi, Tatsuto Hamatani, Tatsuo Kagimura, Hiroaki Yanagawa, Hideki Mochizuki, Manabu Doyu, Gen Sobue, Masafumi Harada and Yuishin Izumi :
An Exploratory Trial of EPI-589 in Amyotrophic Lateral Sclerosis (EPIC-ALS): Protocol for a Multicenter, Open-Labeled, 24-Week, Single-Group Study,
JMIR Research Protocols, Vol.12, e42032, 2023.

(要約): Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder, with its currently approved drugs, including riluzole and edaravone, showing limited therapeutic effects. Therefore, safe and effective drugs are urgently necessary. EPI-589 is an orally available, small-molecule, novel redox-active agent characterized by highly potent protective effects against oxidative stress with high blood-brain barrier permeability. Given the apparent oxidative stress and mitochondrial dysfunction involvement in the pathogenesis of ALS, EPI-589 may hold promise as a therapeutic agent. This protocol aims to describe the design and rationale for the EPI-589 Early Phase 2 Investigator-Initiated Clinical Trial for ALS (EPIC-ALS). EPIC-ALS is an explorative, open-labeled, single-arm trial that evaluates the safety and tolerability of EPI-589 in patients with ALS. This trial consists of 12-week run-in, 24-week treatment, and 4-week follow-up periods. Patients will receive 500 mg of EPI-589 3 times daily over the 24-week treatment period. Clinical assessments include the mean monthly change of Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised total score. The biomarkers are selected to analyze the effect on oxidative stress and neuronal damage. The plasma biomarkers are 8-hydroxy-2'-deoxyguanosine (8-OHdG), 3-nitrotyrosine (3-NT), neurofilament light chain (NfL), phosphorylated neurofilament heavy chain (pNfH), homocysteine, and creatinine. The cerebrospinal fluid biomarkers are 8-OHdG, 3-NT, NfL, pNfH, and ornithine. The magnetic resonance biomarkers are fractional anisotropy in the corticospinal tract and N-acetylaspartate in the primary motor area. This trial began data collection in September 2021 and is expected to be completed in October 2023. This study can provide useful data to understand the characteristics of EPI-589. Japan Primary Registries Network jRCT2061210031; tinyurl.com/2p84emu6. DERR1-10.2196/42032.
(徳島大学機関リポジトリ): ● Metadata: 118866
(出版サイトへのリンク): ● Publication site (DOI): 10.2196/42032
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36716091; ● Summary page in Scopus @ Elsevier: 2-s2.0-85149143248

(徳島大学機関リポジトリ: 118866, DOI: 10.2196/42032, PubMed: 36716091, Elsevier: Scopus) 亀井友志, 武藤浩平, 山本雄貴, 藤田浩司, 和泉唯信, 原倫世 :
重症筋無力症との鑑別を要したクッシング病の1例,
四国医学雑誌, Vol.78, No.5-6, 221-226, 2022年.

(要約): The patient is a 77-year-old woman with a history of diabetes mellitus that was refractory to the medication and dietary restrictions. Four months prior to the admission, she developed a dropped head and ptosis that worsened in the evening. These symptoms were improved by the edrophonium test and the 3 Hz repetitive nerve stimulation testing was positive ; nevertheless, anti-acetylcholine and anti-muscle-specific tyrosine kinase antibodies were negative. Further examination demonstrated sustained hypokalemia and high levels of cortisol and ACTH. Moreover, CRH and high-dose dexamethasone suppression testings were positive and MRI demonstrated pituitary microadenoma. Based on these findings, she was subsequently diagnosed with Cushing's disease. After the resection of the pituitary tumor, ptosis improved with an alleviation of systemic edema, suggesting that it was caused by an eyelid edema. This case uniquely illustrates that Cushing's disease may mimic myasthenia gravis. Differentiation of the two disorders is crucial as treatment with steroids could compromise the interpretation of diagnostic testings for Cushing's disease and might result in a disease exacerbation. In this case, the history of treatment-refractory diabetes mellitus was helpful cue to differentiate the two disorders.
(キーワード): Cushing's disease / Myasthenia gravis / Dropped head / Ptosis / Eyelid edema
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1050576656656588544

(CiNii: 1050576656656588544) K Imamura, Yuishin Izumi, M Nagai, K Nishiyama, Y Watanabe, R Hanajima, N Egawa, T Ayaki, R Oki, Koji Fujita, R Uozumi, A Morinaga, T Hirohashi, Y Fujii, T Yamamoto, H Tatebe, T Tokuda, N Takahashi, S Morita, R Takahashi and H Inoue :
Safety and tolerability of bosutinib in patients with amyotrophic lateral sclerosis (iDReAM study): A multicentre, open-label, dose-escalation phase 1 trial,
eClinicalMedicine, Vol.53, 101707, 2022.

(要約): Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease caused by the loss of motor neurons, and development of effective medicines is urgently required. Induced pluripotent stem cell (iPSC)-based drug repurposing identified the Src/c-Abl inhibitor bosutinib, which is approved for the treatment of chronic myelogenous leukemia (CML), as a candidate for the molecular targeted therapy of ALS. An open-label, multicentre, dose-escalation phase 1 study using a 3 + 3 design was conducted in 4 hospitals in Japan to evaluate the safety and tolerability of bosutinib in patients with ALS. Furthermore, the exploratory efficacy was evaluated using Revised ALS Functional Rating Scale (ALSFRS-R), predictive biomarkers including plasma neurofilament light chain (NFL) were explored, and single-cell RNA sequencing of iPSC-derived motor neurons was conducted. Patients, whose total ALSFRS-R scores decreased by 1-3 points during the 12-week, received escalating doses starting from 100 mg quaque die (QD) up to 400 mg QD based on dose-limiting toxicity (DLT) occurrence, and all participants who received one dose of the study drug were included in the primary analysis. This trial is registered with ClinicalTrials.gov, NCT04744532, as Induced pluripotent stem cell-based Drug Repurposing for Amyotrophic Lateral Sclerosis Medicine (iDReAM) study. Between March 29, 2019 and May 7, 2021, 20 patients were enrolled, 13 of whom received bosutinib treatment and 12 were included in the safety and efficacy analyses. No DLTs were observed up to 300 mg QD, but DLTs were observed in 3/3 patients of the 400 mg QD cohort. In all patients receiving 100 mg-400 mg, the prevalent adverse events (AEs) were gastrointestinal AEs in 12 patients (92.3%), liver function related AEs in 7 patients (53.8%), and rash in 3 patients (23.1%). The safety profile was consistent with that known for CML treatment, and ALS-specific AEs were not observed. A subset of patients (5/9 patients) was found to respond well to bosutinib treatment over the 12-week treatment period. It was found that the treatment-responsive patients could be distinguished by their lower levels of plasma NFL. Furthermore, single-cell RNA sequencing of iPSC-derived motor neurons revealed the pathogenesis related molecular signature in patients with ALS showing responsiveness to bosutinib. This is the first trial of a Src/c-Abl inhibitor, bosutinib, for patients with ALS. The safety and tolerability of bosutinib up to 300 mg, not 400 mg, in ALS were described, and responsiveness of patients on motor function was observed. Since this was an open-label trial within a short period with a limited number of patients, further clinical trials will be required. AMED and iPS Cell Research Fund.
(徳島大学機関リポジトリ): ● Metadata: 118726
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.eclinm.2022.101707
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36467452; ● Search Scopus @ Elsevier (PMID): 36467452; ● Search Scopus @ Elsevier (DOI): 10.1016/j.eclinm.2022.101707

(徳島大学機関リポジトリ: 118726, DOI: 10.1016/j.eclinm.2022.101707, PubMed: 36467452) M Chuluunbat, D Matsuda, Koji Fujita, M Otomo, Youichi Otomi, K Kudo, Masafumi Harada and Yuishin Izumi :
Identification and validation of a gray matter volume network in Alzheimer's disease,
Journal of the Neurological Sciences, Vol.440, 120344, 2022.

(要約): This study aims to identify and validate a gray matter volume network in patients with Alzheimer's disease (AD). To identify a disease-related network, a principal component analysis-based algorithm, Scaled Subprofile Model, was applied to gray matter volume data derived from structural T1-weighted magnetic resonance imaging of the training sample that consisted of nine patients with AD (women, four; dementia, seven; mild cognitive impairment, two; age, 66.7 ± 8.8 [mean ± SD] years) with positive F-flutemetamol amyloid positron emission tomography and eight age-matched healthy controls obtained on-site. The network expression scores were calculated by topographic profile rating in the validation sample obtained via the Open Access Series of Imaging Studies and comprised 12 patients with AD dementia (women, four; age, 70.0 ± 3.7 years) and 12 age-matched healthy controls. A significant network from the training sample, for which subject expression differed between the groups (permutation test, P = 0.006; sensitivity and specificity, 100%; area under the curve, 1), was identified. This network was represented by the principal components 1, 2, and 3 and showed a relative decrease in the inferior parietal lobule including angular gyrus, inferior temporal gyrus, premotor cortex, amygdala, hippocampus, and precuneus. It significantly differed between the groups with a sensitivity, specificity, and area under the curve of 83%, 91%, and 0.85, respectively, in the validation sample (P = 0.003). An AD-related gray matter volume network that captured relevant regions was identified in amyloid positron emission tomography-positive patients and validated in an independent sample.
(キーワード): Aged / Alzheimer Disease / Amyloid / Brain / Cognitive Dysfunction / Female / Gray Matter / Humans / Magnetic Resonance Imaging / Male / Middle Aged / Positron-Emission Tomography
(徳島大学機関リポジトリ): ● Metadata: 119325
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jns.2022.120344
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35908305; ● Search Scopus @ Elsevier (PMID): 35908305; ● Search Scopus @ Elsevier (DOI): 10.1016/j.jns.2022.120344

(徳島大学機関リポジトリ: 119325, DOI: 10.1016/j.jns.2022.120344, PubMed: 35908305) Koji Fukushima, Naoko Takamatsu, Yuki Yamamoto, Hiroki Yamazaki, Takeshi Yoshida, Yusuke Osaki, Shotaro Haji, Koji Fujita, Kazuma Sugie and Yuishin Izumi :
Early diagnosis of amyotrophic lateral sclerosis based on fasciculations in muscle ultrasonography: A machine learning approach.,
Clinical Neurophysiology, Vol.140, 136-144, 2022.

(要約): We investigated 100 patients with ALS, including 50 with early-stage ALS within 9 months from onset, and 100 without ALS. Fifteen muscles were bilaterally observed for 10 s each and the presence of fasciculations was recorded. Hierarchical clustering and nominal logistic regression, neural network, or ensemble learning were applied to the training cohort comprising the early-stage ALS to develop MUS-based diagnostic models, and they were tested in the validation cohort comprising the later-stage ALS.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.clinph.2022.06.005
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35772191; ● Search Scopus @ Elsevier (PMID): 35772191; ● Search Scopus @ Elsevier (DOI): 10.1016/j.clinph.2022.06.005

(DOI: 10.1016/j.clinph.2022.06.005, PubMed: 35772191) Ryosuke Oki, Yuishin Izumi, Koji Fujita, Ryosuke Miyamoto, Hiroyuki Nodera, Yasutaka Sato, Satoshi Sakaguchi, Hiroshi Nokihara, Kazuaki Kanai, Taiji Tsunemi, Nobutaka Hattori, Yuki Hatanaka, Masahiro Sonoo, Naoki Atsuta, Gen Sobue, Toshio Shimizu, Kazumoto Shibuya, Ken Ikeda, Osamu Kano, Kazuto Nishinaka, Yasuhiro Kojima, Masaya Oda, Kiyonobu Komai, Hitoshi Kikuchi, Nobuo Kohara, Makoto Urushitani, Yoshiaki Nakayama, Hidefumi Ito, Makiko Nagai, Kazutoshi Nishiyama, Daisuke Kuzume, Shun Shimohama, Takayoshi Shimohata, Koji Abe, Tomohiko Ishihara, Osamu Onodera, Sagiri Isose, Nobuyuki Araki, Mitsuya Morita, Kazuyuki Noda, Tatsushi Toda, Hirofumi Maruyama, Hirokazu Furuya, Satoshi Teramukai, Tatsuo Kagimura, Kensuke Noma, Hiroaki Yanagawa, Satoshi Kuwabara and Ryuji Kaji :
Efficacy and Safety of Ultrahigh-Dose Methylcobalamin in Early-Stage Amyotrophic Lateral Sclerosis: A Randomized Clinical Trial.,
JAMA Neurology, Vol.79, No.6, 575-583, 2022.

(要約): A total of 130 patients (mean [SD] age, 61.0 [11.7] years; 74 men [56.9%]) were randomly assigned to methylcobalamin or placebo (65 each). A total of 129 patients were eligible for the full analysis set, and 126 completed the double-blind stage. Of these, 124 patients proceeded to the open-label extended period. The least square means difference in ALSFRS-R total score at week 16 of the randomized period was 1.97 points greater with methylcobalamin than placebo (-2.66 vs -4.63; 95% CI, 0.44-3.50; P = .01). The incidence of adverse events was similar between the 2 groups.
(キーワード): Amyotrophic Lateral Sclerosis / Double-Blind Method / Humans / Male / Middle Aged / Treatment Outcome / Vital Capacity / Vitamin B 12
(徳島大学機関リポジトリ): ● Metadata: 118371
(出版サイトへのリンク): ● Publication site (DOI): 10.1001/jamaneurol.2022.0901
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35532908; ● Search Scopus @ Elsevier (PMID): 35532908; ● Search Scopus @ Elsevier (DOI): 10.1001/jamaneurol.2022.0901

(徳島大学機関リポジトリ: 118371, DOI: 10.1001/jamaneurol.2022.0901, PubMed: 35532908) Naohiro Egawa, Yuishin Izumi, Hidefumi Suzuki, Itaru Tsuge, Koji Fujita, Hitoshi Shimano, Keiichi Izumikawa, Nobuhiro Takahashi, Kayoko Tsukita, Takako Enami, Masahiro Nakamura, Akira Watanabe, Motoko Naitoh, Shigehiko Suzuki, Tsuneyoshi Seki, Kazuhiro Kobayashi, Tatsushi Toda, Ryuji Kaji, Ryosuke Takahashi and Haruhisa Inoue :
TDP-43 regulates cholesterol biosynthesis by inhibiting sterol regulatory element-binding protein 2.,
Scientific Reports, Vol.12, No.1, 2022.

(要約): Dyslipidemia is considered an essential component of the pathological process of amyotrophic lateral sclerosis (ALS), a fatal motor neuron disease. Although TAR DNA Binding Protein 43 kDa (TDP-43) links both familial and sporadic forms of ALS and cytoplasmic aggregates are a hallmark of most cases of ALS, the molecular mechanism and the in vivo relation of ALS dyslipidemia with TDP-43 have been unclear. To analyze the dyslipidemia-related gene expression by TDP-43, we performed expression microarray and RNA deep sequencing (RNA-Seq) using cell lines expressing high levels of TDP-43 and identified 434 significantly altered genes including sterol regulatory element-binding protein 2 (SREBP2), a master regulator of cholesterol homeostasis and its downstream genes. Elevated TDP-43 impaired SREBP2 transcriptional activity, leading to inhibition of cholesterol biosynthesis. The amount of cholesterol was significantly decreased in the spinal cords of TDP-43-overexpressed ALS model mice and in the cerebrospinal fluids of ALS patients. These results suggested that TDP-43 could play an essential role in cholesterol biosynthesis in relation to ALS dyslipidemia.
(キーワード): Amyotrophic Lateral Sclerosis / Animals / DNA-Binding Proteins / Humans / Mice / Motor Neuron Disease / Sterol Regulatory Element Binding Protein 2 / Sterols
(徳島大学機関リポジトリ): ● Metadata: 117387
(出版サイトへのリンク): ● Publication site (DOI): 10.1038/s41598-022-12133-4
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35568729; ● Search Scopus @ Elsevier (PMID): 35568729; ● Search Scopus @ Elsevier (DOI): 10.1038/s41598-022-12133-4

(徳島大学機関リポジトリ: 117387, DOI: 10.1038/s41598-022-12133-4, PubMed: 35568729) Shinichi Matsumoto, Yuki Yamamoto, Koji Fujita, Ryosuke Miyamoto, Hidetaka Koizumi, Akihiro Tateishi, Naoaki Yamada and Yuishin Izumi :
Truncal dystonia with isolated middle cerebral artery ischemia: A case report of revascularization therapy for dystonia.,
Surgical Neurology International, Vol.13, 2022.

(要約): Revascularization therapy improved CBF and truncal dystonia and could be a viable treatment option for dystonia with ischemia in the MCA region. Extensive cerebral ischemia can result in cortical inhibition loss or over-adapted cerebral plasticity and cause dystonia. Revascularization therapy may be useful for patients with dystonia and decreased CBF in the MCA region.
(出版サイトへのリンク): ● Publication site (DOI): 10.25259/SNI_173_2022
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35509528; ● Search Scopus @ Elsevier (PMID): 35509528; ● Search Scopus @ Elsevier (DOI): 10.25259/SNI_173_2022

(DOI: 10.25259/SNI_173_2022, PubMed: 35509528) T Fukumoto, Ryosuke Miyamoto, Koji Fujita, Masafumi Harada and Yuishin Izumi :
Gait apraxia as a presenting sign of Gerstmann-Sträussler-Scheinker disease,
Neurology and Clinical Neuroscience, Vol.9, No.4, 339-341, 2021.

(出版サイトへのリンク): ● Publication site (DOI): 10.1111/ncn3.12511
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1111/ncn3.12511

(DOI: 10.1111/ncn3.12511) Takayuki Kondo, Haruhiko Banno, Taro Okunomiya, Yoko Amino, Kayoko Endo, Akiyoshi Nakakura, Ryuji Uozumi, Akemi Kinoshita, Harue Tada, Satoshi Morita, Hidehiro Ishikawa, Akihiro Shindo, Ken Yasuda, Yosuke Taruno, Takakuni Maki, Takashi Suehiro, Kohji Mori, Manabu Ikeda, Koji Fujita, Yuishin Izumi, Kazutomi Kanemaru, Kenji Ishii, Kazue Shigenobu, Yumiko Kutoku, Yoshihide Sunada, Shinobu Kawakatsu, Shunji Shiota, Toshifumi Watanabe, Osamu Uchikawa, Ryosuke Takahashi, Hidekazu Tomimoto and Haruhisa Inoue :
Repurposing bromocriptine for Aβ metabolism in Alzheimer's disease (REBRAnD) study: randomised placebo-controlled double-blind comparative trial and open-label extension trial to investigate the safety and efficacy of bromocriptine in Alzheimer's disease with presenilin 1 (PSEN1) mutations,
BMJ Open, Vol.11, No.6, e051343, 2021.

(要約): Alzheimer's disease (AD) is one of the most common causes of dementia. Pathogenic variants in the presenilin 1 (PSEN1) gene are the most frequent cause of early-onset AD. Medications for patients with AD bearing PSEN1 mutation (PSEN1-AD) are limited to symptomatic therapies and no established radical treatments are available. Induced pluripotent stem cell (iPSC)-based drug repurposing identified bromocriptine as a therapeutic candidate for PSEN1-AD. In this study, we used an enrichment strategy with iPSCs to select the study population, and we will investigate the safety and efficacy of an orally administered dose of bromocriptine in patients with PSEN1-AD. This is a multicentre, randomised, placebo-controlled trial. AD patients with PSEN1 mutations and a Mini Mental State Examination-Japanese score of ≤25 will be randomly assigned, at a 2:1 ratio, to the trial drug or placebo group (≥4 patients in TW-012R and ≥2 patients in placebo). This clinical trial consists of a screening period, double-blind phase (9 months) and extension phase (3 months). The double-blind phase for evaluating the efficacy and safety is composed of the low-dose maintenance period (10 mg/day), high-dose maintenance period (22.5 mg/day) and tapering period of the trial drug. Additionally, there is an open-labelled active drug extension period for evaluating long-term safety. Primary outcomes are safety and efficacy in cognitive and psychological function. Also, exploratory investigations for the efficacy of bromocriptine by neurological scores and biomarkers will be conducted. The proposed trial is conducted according to the Declaration of Helsinki, and was approved by the Institutional Review Board (K070). The study results are expected to be disseminated at international or national conferences and published in international journals following the peer-review process. jRCT2041200008, NCT04413344.
(キーワード): Alzheimer Disease / Bromocriptine / Double-Blind Method / Drug Repositioning / Humans / Mutation / Presenilin-1 / Treatment Outcome
(徳島大学機関リポジトリ): ● Metadata: 116497
(出版サイトへのリンク): ● Publication site (DOI): 10.1136/bmjopen-2021-051343
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34193504; ● Summary page in Scopus @ Elsevier: 2-s2.0-85110062731

(徳島大学機関リポジトリ: 116497, DOI: 10.1136/bmjopen-2021-051343, PubMed: 34193504, Elsevier: Scopus) Hiroshi Koyama, Hideo Mure, Ryoma Morigaki, Ryosuke Miyamoto, Kazuhisa Miyake, Taku Matsuda, Koji Fujita, Yuishin Izumi, Ryuji Kaji, Satoshi Goto and Yasushi Takagi :
Long-Term Follow-Up of 12 Patients Treated with Bilateral Pallidal Stimulation for Tardive Dystonia,
Life, Vol.11, No.6, 477, 2021.

(要約): Tardive dystonia (TD) is a side effect of prolonged dopamine receptor antagonist intake. TD can be a chronic disabling movement disorder despite medical treatment. We previously demonstrated successful outcomes in six patients with TD using deep brain stimulation (DBS); however, more patients are needed to better understand the efficacy of DBS for treating TD. We assessed the outcomes of 12 patients with TD who underwent globus pallidus internus (GPi) DBS by extending the follow-up period of previously reported patients and enrolling six additional patients. All patients were refractory to pharmacotherapy and were referred for surgical intervention by movement disorder neurologists. In all patients, DBS electrodes were implanted bilaterally within the GPi under general anesthesia. The mean ages at TD onset and surgery were 39.2 ± 12.3 years and 44.6 ± 12.3 years, respectively. The Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS) performed the preoperative and postoperative evaluations. The average BFMDRS improvement rate at 1 month postoperatively was 75.6 ± 27.6% ( < 0.001). Ten patients were assessed in the long term (78.0 ± 50.4 months after surgery), and the long-term BFMDRS improvement was 78.0 ± 20.4%. Two patients responded poorly to DBS. Both had a longer duration from TD onset to surgery and older age at surgery. A cognitive and psychiatric decline was observed in the oldest patients, while no such decline ware observed in the younger patients. In most patients with TD, GPi-DBS could be a beneficial therapeutic option for long-term relief of TD.
(徳島大学機関リポジトリ): ● Metadata: 116561
(出版サイトへのリンク): ● Publication site (DOI): 10.3390/life11060477
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34074009; ● Summary page in Scopus @ Elsevier: 2-s2.0-85107554331

(徳島大学機関リポジトリ: 116561, DOI: 10.3390/life11060477, PubMed: 34074009, Elsevier: Scopus) Kohei Muto, Ryosuke Miyamoto, Yuka Terasawa, Yoshimitsu Shimatani, Keijiro Hara, Takumi Kakimoto, Tatsuya Fukumoto, Yusuke Osaki, Koji Fujita, Masafumi Harada, Hisanori Uehara, Yasushi Takagi and Yuishin Izumi :
A novel COL4A1 variant associated with recurrent epistaxis and glioblastoma,
Human Genome Variation, Vol.8, No.1, 18, 2021.

(徳島大学機関リポジトリ): ● Metadata: 116530
(出版サイトへのリンク): ● Publication site (DOI): 10.1038/s41439-021-00150-0
(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-85105944271

(徳島大学機関リポジトリ: 116530, DOI: 10.1038/s41439-021-00150-0, Elsevier: Scopus) Koji Fujita, Shichun Peng, Yilong Ma, C Chris Tang, Matthew Hellman, Andrew Feigin, David Eidelberg and Vijay Dhawan :
Blood-brain barrier permeability in Parkinson's disease patients with and without dyskinesia.,
Journal of Neurology, Vol.268, No.6, 2246-2255, 2021.

(要約): Rb PET did not reveal significant changes in BBB permeability in PD patients.
(キーワード): Antiparkinson Agents / 血液脳関門 (blood-brain barrier) / Dyskinesias / Humans / Levodopa / パーキンソン病 (Parkinson's disease) / Permeability
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s00415-021-10411-1
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33502551; ● Search Scopus @ Elsevier (PMID): 33502551; ● Search Scopus @ Elsevier (DOI): 10.1007/s00415-021-10411-1

(DOI: 10.1007/s00415-021-10411-1, PubMed: 33502551) T Fukumoto, Ryosuke Miyamoto, Koji Fujita, N Murakami, Naoko Matsui and Yuishin Izumi :
Reversible mixed perfusion on 123 I-IMP SPECT in anti-AMPA receptor encephalitis: A case report,
Journal of the Neurological Sciences, Vol.421, 117306, 2021.

(キーワード): Encephalitis / Humans / Inosine Monophosphate / Iodine Radioisotopes / Iofetamine / Perfusion / Receptors, AMPA / Tomography, Emission-Computed, Single-Photon
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jns.2020.117306
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33450618; ● Search Scopus @ Elsevier (PMID): 33450618; ● Search Scopus @ Elsevier (DOI): 10.1016/j.jns.2020.117306

(DOI: 10.1016/j.jns.2020.117306, PubMed: 33450618) Ryoma Morigaki, Ryosuke Miyamoto, Hideo Mure, Koji Fujita, Taku Matsuda, Yoko Yamamoto, Masahito Nakataki, Tetsuya Okahisa, Yuki Matsumoto, Kazuhisa Miyake, Nobuaki Yamamoto, Ryuji Kaji, Yasushi Takagi and Satoshi Goto :
Can Pallidal Deep Brain Stimulation Rescue Borderline Dystonia? Possible Coexistence of Functional (Psychogenic) and Organic Components.,
Brain Sciences, Vol.10, No.9, 636, 2020.

(要約): The diagnosis and treatment of functional movement disorders are challenging for clinicians who manage patients with movement disorders. The borderline between functional and organic dystonia is often ambiguous. Patients with functional dystonia are poor responders to pallidal deep brain stimulation (DBS) and are not good candidates for DBS surgery. Thus, if patients with medically refractory dystonia have functional features, they are usually left untreated with DBS surgery. In order to investigate the outcome of functional dystonia in response to pallidal DBS surgery, we retrospectively included five patients with this condition. Their dystonia was diagnosed as organic by dystonia specialists and also as functional according to the Fahn and Williams criteria or the Gupta and Lang Proposed Revisions. Microelectrode recordings in the globus pallidus internus of all patients showed a cell-firing pattern of bursting with interburst intervals, which is considered typical of organic dystonia. Although their clinical course after DBS surgery was incongruent to organic dystonia, the outcome was good. Our results question the possibility to clearly differentiate functional dystonia from organic dystonia. We hypothesized that functional dystonia can coexist with organic dystonia, and that medically intractable dystonia with combined functional and organic features can be successfully treated by DBS surgery.
(徳島大学機関リポジトリ): ● Metadata: 116502
(出版サイトへのリンク): ● Publication site (DOI): 10.3390/brainsci10090636
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32942724; ● Search Scopus @ Elsevier (PMID): 32942724; ● Search Scopus @ Elsevier (DOI): 10.3390/brainsci10090636

(徳島大学機関リポジトリ: 116502, DOI: 10.3390/brainsci10090636, PubMed: 32942724) Hideo Mure, Naoto Toyoda, Ryoma Morigaki, Koji Fujita and Yasushi Takagi :
Clinical Outcome and Intraoperative Neurophysiology of the Lance-Adams Syndrome Treated with Bilateral Deep Brain Stimulation of the Globus Pallidus Internus: A Case Report and Review of the Literature.,
Stereotactic and Functional Neurosurgery, Vol.98, No.6, 399-403, 2020.

(要約): Our results show that impairment in the basal ganglion circuitry might be involved in the pathogenesis of myoclonus in patients with LAS.
(キーワード): Aged / Deep Brain Stimulation / Female / Globus Pallidus / Humans / Hypoxia-Ischemia, Brain / Intraoperative Neurophysiological Monitoring / Microelectrodes / Myoclonus / Treatment Outcome
(出版サイトへのリンク): ● Publication site (DOI): 10.1159/000509318
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32894852; ● Search Scopus @ Elsevier (PMID): 32894852; ● Search Scopus @ Elsevier (DOI): 10.1159/000509318

(DOI: 10.1159/000509318, PubMed: 32894852) Yamamoto Yuki, Nobuaki Yamamoto, Koji Fujita, Fukumoto Tatsuya, Murakami Nagahisa, Hideo Mure, Yasuhisa Kanematsu, Yasushi Takagi and Yuishin Izumi :
Cerebral Venous Thrombosis: An Unexpected Complication with Cerebrospinal Fluid Leaks after a Fall in a Patient with Spinocerebellar Ataxia Type 6.,
Internal Medicine, Vol.59, No.14, 1749-1753, 2020.

(徳島大学機関リポジトリ): ● Metadata: 115918
(出版サイトへのリンク): ● Publication site (DOI): 10.2169/internalmedicine.4388-20
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32238726; ● Search Scopus @ Elsevier (PMID): 32238726; ● Search Scopus @ Elsevier (DOI): 10.2169/internalmedicine.4388-20

(徳島大学機関リポジトリ: 115918, DOI: 10.2169/internalmedicine.4388-20, PubMed: 32238726) Koji Fujita, Tomoyasu Matsubara, Ryosuke Miyamoto, Hiroyuki Sumikura, Toshiaki Takeuchi, Keiko Saladini Maruyama, Toshitaka Kawarai, Hiroyuki Nodera, Fukashi Udaka, Kodai Kume, Hiroyuki Morino, Hideshi Kawakami, Masato Hasegawa, Ryuji Kaji, Shigeo Murayama and Yuishin Izumi :
Co-morbidity of progressive supranuclear palsy and amyotrophic lateral sclerosis: a clinical-pathological case report.,
BMC Neurology, Vol.19, No.1, 168, 2019.

(要約): A 77-year-old man presented with gait disturbance for 2 years, consistent with PSP with progressive gait freezing. At 79 years old, he developed muscle weakness compatible with ALS. The disease duration was 5 years after the onset of PSP and 5 months after the onset of ALS. Neuropathological findings demonstrated the coexistence of PSP and ALS. Immunohistochemical examination confirmed 4-repeat tauopathy, including globose-type neurofibrillary tangles, tufted astrocytes, and oligodendroglial coiled bodies as well as TAR DNA-binding protein 43 kDa pathology in association with upper and lower motor neuron degeneration. Immunoblotting showed hyperphosphorylated full-length 4-repeat tau bands (64 and 68 kDa) and C-terminal fragments (33 kDa), supporting the diagnosis of PSP and excluding other parkinsonian disorders, such as corticobasal degeneration. Genetic studies showed no abnormalities in genes currently known to be related to ALS or PSP.
(徳島大学機関リポジトリ): ● Metadata: 114373
(出版サイトへのリンク): ● Publication site (DOI): 10.1186/s12883-019-1402-7
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31319800; ● Search Scopus @ Elsevier (PMID): 31319800; ● Search Scopus @ Elsevier (DOI): 10.1186/s12883-019-1402-7

(徳島大学機関リポジトリ: 114373, DOI: 10.1186/s12883-019-1402-7, PubMed: 31319800) Yuishin Izumi, Ryosuke Miyamoto, Koji Fujita, Yuki Yamamoto, Hirotsugu Yamada, Tomoyasu Matsubara, Yuki Unai, Ai Tsukamoto, Naoko Takamatsu, Hiroyuki Nodera, Shinya Hayashi, Masaya Oda, Atsuko Mori, Yoshihiko Nishida, Shunsuke Watanabe, Hirohisa Ogawa, Hisanori Uehara, Shigeo Murayama, Masataka Sata and Ryuji Kaji :
Distinct Incidence of Takotsubo Syndrome Between Amyotrophic Lateral Sclerosis and Synucleinopathies: A Cohort Study.,
Frontiers in Neurology, Vol.9, 1099, 2018.

(要約): Takotsubo syndrome (TTS) is an acute cardiac syndrome characterized by regional left ventricular dysfunction with a peculiar circumferential pattern, which typically results in apical ballooning. Evidence indicates a pivotal role of catecholamines in TTS, and researchers have discussed multiple hypotheses on the etiology, including multivessel coronary spasm, myocardial stunning, excessive transient ventricular afterload, and cardiac sympathetic overactivity with local noradrenaline spillover. Although central nervous system disorders, such as stroke and epilepsy, are known to trigger TTS, the incidence and clinical features of TTS in neurodegenerative disorders are poorly understood. Here, we retrospectively examined TTS cases in a single-center cohort composed of 250 patients with amyotrophic lateral sclerosis (ALS) and 870 patients with synucleinopathies [582 patients with Parkinson's disease (PD), 125 patients with dementia with Lewy bodies (DLB), and 163 patients with multiple system atrophy (MSA)] and identified 4 (1.6%, including 2 women) cases with ALS and no cases with synucleinopathies. Two ALS patients underwent autopsy and the pathological findings were compatible with the chronological changes identified in catecholamine-induced cardiomyopathy. A literature review identified 16 TTS cases with ALS, 1 case each with PD and DLB, and no cases with MSA. When current and previous TTS cases with ALS were concatenated: 55% (11/20) were female; 35% (7/20) had a bulbar-onset and 45% (9/20) had a limb-onset; the mean age of TTS onset was 63.3 ± 9.0 years and the mean interval time from ALS onset to TTS development was 4.9 ± 3.0 years; no (0/16) patients developed TTS within 12 months after ALS onset; 50% (10/20) underwent artificial ventilations; the mortality was 17% (3/18); and most cases had precipitating factors, and TTS development was associated with gastrostomy, tracheostomy, or infections in 45% (9/20) of the patients. This study demonstrated that ALS is a considerable predisposing factor of TTS and that synucleinopathies rarely cause TTS. The distinct TTS incidence between ALS and synucleinopathies may be due to cardiac sympathetic overactivity in ALS and may also be affected by cardiac sympathetic denervation in synucleinopathies. Moreover, the etiology of TTS in ALS may be reasonably explained by the two-hit theory.
(徳島大学機関リポジトリ): ● Metadata: 113228
(出版サイトへのリンク): ● Publication site (DOI): 10.3389/fneur.2018.01099
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30619056; ● Search Scopus @ Elsevier (PMID): 30619056; ● Search Scopus @ Elsevier (DOI): 10.3389/fneur.2018.01099

(徳島大学機関リポジトリ: 113228, DOI: 10.3389/fneur.2018.01099, PubMed: 30619056) Shunya Nakane, Koji Fujita, Shingo Azuma, Ryo Urushihara, Masaki Kamada, Masafumi Harada, Yuishin Izumi and Ryuji Kaji :
CSF cystatin C and diffusion tensor imaging parameters as biomarkers of upper motor neuron degeneration in amyotrophic lateral sclerosis.,
Clinical Neurology and Neurosurgery, Vol.172, 162-168, 2018.

(要約): MR findings indicated that decreased anisotropy, increased diffusion, and increased myo-inositol/creatine ratio were also significantly correlated with UMN involvement in patients with ALS. The CSF cystatin C levels were significantly lower in patients with ALS than in the other three groups. The reduction of CSF cystatin C levels was significantly correlated with clinical UMN involvement (r = -0.505, p = 0.023).
(キーワード): Adult / Aged / Aged, 80 and over / Amyotrophic Lateral Sclerosis / Biomarkers / Cystatin C / Diffusion Magnetic Resonance Imaging / Diffusion Tensor Imaging / Female / Humans / Magnetic Resonance Spectroscopy / Male / Middle Aged / Motor Neurons / Multimodal Imaging / Nerve Degeneration
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.clineuro.2018.07.008
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30016754; ● Search Scopus @ Elsevier (PMID): 30016754; ● Search Scopus @ Elsevier (DOI): 10.1016/j.clineuro.2018.07.008

(DOI: 10.1016/j.clineuro.2018.07.008, PubMed: 30016754) Koji Fujita, Wataru Sako, An Vo, Susan B. Bressman and David Eidelberg :
Disruption of network for visual perception of natural motion in primary dystonia.,
Human Brain Mapping, Vol.39, No.3, 1163-1174, 2017.

(要約): In healthy subjects, brain activation in motor regions is greater during the visual perception of "natural" target motion, which complies with the two-thirds power law, than of "unnatural" motion, which does not. It is unknown whether motion perception is normally mediated by a specific network that can be altered in the setting of disease. We used block-design functional magnetic resonance imaging and covariance analysis to identify normal network topographies activated in response to "natural" versus "unnatural" motion. A visual motion perception-related pattern (VPRP) was identified in 12 healthy subjects, characterized by covarying activation responses in the inferior parietal lobule, frontal operculum, lateral occipitotemporal cortex, amygdala, and cerebellum (Crus I). Selective VPRP activation during "natural" motion was confirmed in 12 testing scans from healthy subjects. Consistent network activation was not seen, however, in 29 patients with dystonia, a neurodevelopmental disorder in which motion perception pathways may be involved. Using diffusion tractography, we evaluated the integrity of anatomical connections between the major VPRP nodes. Indeed, fiber counts in these pathways were substantially reduced in the dystonia subjects. In aggregate, the findings associate normal motion perception with a discrete brain network which can be disrupted under pathological conditions.
(出版サイトへのリンク): ● Publication site (DOI): 10.1002/hbm.23907
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29214728; ● Search Scopus @ Elsevier (PMID): 29214728; ● Search Scopus @ Elsevier (DOI): 10.1002/hbm.23907

(DOI: 10.1002/hbm.23907, PubMed: 29214728) Koji Fujita, Yusuke Osaki, Ryosuke Miyamoto, Shimatani Yoshimitsu, Takashi Abe and Shimatani Yoshimitsu :
Neurologic attack and dynamic perfusion abnormality in neuronal intranuclear inclusion disease,
Neurology. Clinical Practice, Vol.7, No.6, e39-e42, 2017.

(出版サイトへのリンク): ● Publication site (DOI): 10.1212/CPJ.0000000000000389
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29431160; ● Search Scopus @ Elsevier (PMID): 29431160; ● Search Scopus @ Elsevier (DOI): 10.1212/CPJ.0000000000000389

(DOI: 10.1212/CPJ.0000000000000389, PubMed: 29431160) P Renata Lerner, Veronica Francardo, Koji Fujita, Zisis Bimpisidis, A Vincent Jourdain, C Chris Tang, L Stephen Dewey, Thomas Chaly, Angela M Cenci and David Eidelberg :
Levodopa-induced abnormal involuntary movements correlate with altered permeability of the blood-brain-barrier in the basal ganglia.,
Scientific Reports, Vol.7, No.1, 2017.

(要約): C]-AIB uptake in the ipsilateral GP, which correlated with AIMs scores. Histopathological analysis revealed high levels of microvascular nestin immunoreactivity in the same region. The findings demonstrate that regional flow-metabolism dissociation and increased BBB permeability are simultaneously induced by levodopa within areas of active microvascular remodeling, and that such changes correlate with the severity of dyskinesia.
(キーワード): Animals / Antiparkinson Agents / Basal Ganglia / 血液脳関門 (blood-brain barrier) / Female / Levodopa / Positron Emission Tomography Computed Tomography / Rats / Rats, Sprague-Dawley
(徳島大学機関リポジトリ): ● Metadata: 117769
(出版サイトへのリンク): ● Publication site (DOI): 10.1038/s41598-017-16228-1
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29167476; ● Search Scopus @ Elsevier (PMID): 29167476; ● Search Scopus @ Elsevier (DOI): 10.1038/s41598-017-16228-1

(徳島大学機関リポジトリ: 117769, DOI: 10.1038/s41598-017-16228-1, PubMed: 29167476) Junya Aoki, Kazumi Kimura, Naomi Morita, Masafumi Harada, Norifumi Metoki, Yohei Tateishi, Kenichi Todo, Hiroshi Yamagami, Kouji Hayashi, Yuka Terasawa, Koji Fujita, Nobuaki Yamamoto, Ichiro Deguchi, Norio Tanahashi, Takeshi Inoue, Takeshi Iwanaga, Nobuyuki Kaneko, Hidetaka Mitsumura, Yasuyuki Iguchi, Yasushi Ueno, Yoji Kuramoto, Toshiyasu Ogata, Shigeru Fujimoto, Mutsumi Yokoyama and Shinji Nagahiro :
Tissue type plasminogen activator and edaravone combination therapy: YAMATO study,
Stroke, Vol.48, No.3, 712-719, 2017.

(要約): We investigated whether administration of edaravone, a free radical scavenger, before or during tissue-type plasminogen activator (tPA) can enhance early recanalization in a major arterial occlusion. The YAMATO study (Tissue-Type Plasminogen Activator and Edaravone Combination Therapy) is an investigator-initiated, multicenter (17 hospitals in Japan), prospective, randomized, and open-label study. Patients with stroke secondary to occlusion of the M1 or M2 portion of the middle cerebral artery and within 4.5 hours of the onset were studied. The subjects were randomly allocated to the early group (intravenous edaravone [30 mg] was started before or during tPA) and the late group (edaravone was started after tPA and the assessment of early recanalization). One-hundred sixty-five patients (96 men; median age [interquartile range], of 78 [69-85] years) were randomized 1:1 to either the early group (82 patients) or the late group (83 patients). Primary outcome, defined as an early recanalization 1.5 hour after tPA, was observed in 53% of the early group and in 53% of the late group (P=1.000). About secondary outcomes, the rate of significant recanalization of ≥50% was not different between the 2 groups (28% versus 34%; P=0.393). The symptomatic intracerebral hemorrhage has occurred in 4 patients (5%) in the early group and in 2 patients (2%) in the late group (P=0.443). The favorable outcome (modified Rankin Scale score of 0-2) at 3 months was also similar between the groups (53% versus 57%; P=0.738). The timing of edaravone infusion does not affect the rate of early recanalization, symptomatic intracerebral hemorrhage, or favorable outcome after tPA therapy. URL: http://www.umin.ac.jp/ctr/index-j.htm. Unique identifier: UMIN000006330.
(キーワード): Aged / Aged, 80 and over / Brain Ischemia / Cerebral Hemorrhage / Combined Modality Therapy / 女性 (female) / Fibrinolytic Agents / Humans / 日本 (Japan) / 男性 (male) / Prospective Studies / Stroke / Tissue Plasminogen Activator / Treatment Outcome / Ultrasonography, Doppler, Transcranial
(出版サイトへのリンク): ● Publication site (DOI): 10.1161/STROKEAHA.116.015042
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28119434; ● Summary page in Scopus @ Elsevier: 2-s2.0-85010886796

(DOI: 10.1161/STROKEAHA.116.015042, PubMed: 28119434, Elsevier: Scopus) Takashi Abe, Toshitaka Kawarai, Koji Fujita, Wataru Sako, Yuka Terasawa, Tsuyoshi Matsuda, Waka Sakai, Ai Tsukamoto-Miyashiro, Naoko Matsui, Yuishin Izumi, Ryuji Kaji and Masafumi Harada :
MR Spectroscopy in Patients with Hereditary Diffuse Leukoencephalopathy with Spheroids and Asymptomatic Carriers of Colony-stimulating Factor 1 Receptor Mutation.,
Magnetic Resonance in Medical Sciences, Vol.16, No.4, 297-303, 2016.

(要約): Hereditary diffuse leukoencephalopathy with spheroids (HDLS) is a rare neurodegenerative disorder with various clinical presentations. Mutation of the colony-stimulating factor 1 receptor (CSF1R) gene is considered to be a cause of this autosomal dominant disorder. The purpose of this study was to report magnetic resonance spectroscopy (MRS) findings in patients with HDLS and asymptomatic carriers and to clarify the use of MRS in this disease. In this retrospective, institutional review board-approved study, we included four consecutive patients, genetically diagnosed with HDLS, and two asymptomatic carriers after acquiring informed consent. We performed single-voxel MRS of the left centrum semiovale on a 3-T clinical scanner. We also included a sex-matched normal dataset. We quantified N-acetylaspartate (NAA), creatine, choline-containing compounds (Cho), glutamine, glutamate (Glu), myo-inositol (Ins), glutathione, lactate (Lac), and gamma-amino butyric acid using LCModel. We performed statistical analysis, and P value <0.05 was considered significant. In HDLS cases, MRS revealed decreased NAA and Glu concentrations, which probably reflected neuronal damage and/or loss, and a subsequent reduction of neurotransmitters. A patient with HDLS also had increased Cho and Ins concentrations, indicating gliosis, and increased Cho concentration was also observed in an asymptomatic carrier. This suggests that metabolic changes had already occurred in an asymptomatic state. We demonstrated changes in metabolite concentrations not only in patients with HDLS but also in asymptomatic CSF1R mutation carriers. Our study indicates that MRS is a potentially useful tool for the analysis of metabolic and pathophysiological findings of HDLS, even during the early stages of disease.
(徳島大学機関リポジトリ): ● Metadata: 116229
(出版サイトへのリンク): ● Publication site (DOI): 10.2463/mrms.mp.2016-0016
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28025469; ● Summary page in Scopus @ Elsevier: 2-s2.0-85031294587

(徳島大学機関リポジトリ: 116229, DOI: 10.2463/mrms.mp.2016-0016, PubMed: 28025469, Elsevier: Scopus) Yusuke Osaki, Koji Fujita, Takashi Abe, Masafumi Harada, Yuishin Izumi and Ryuji Kaji :
Mystery Case: Parkinsonism in a diabetic uremic patient.,
Neurology, Vol.86, No.22, e225-7, 2016.

(出版サイトへのリンク): ● Publication site (DOI): 10.1212/WNL.0000000000002713
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27242385; ● Summary page in Scopus @ Elsevier: 2-s2.0-84973577883

(DOI: 10.1212/WNL.0000000000002713, PubMed: 27242385, Elsevier: Scopus) An Vo, Wataru Sako, Koji Fujita, Shichun Peng, J Paul Mattis, M Frank Skidmore, Yilong Ma, M Aziz Uluğ and David Eidelberg :
Parkinson's disease-related network topographies characterized with resting state functional MRI.,
Human Brain Mapping, Vol.38, No.2, 617-630, 2016.

(要約): Spatial covariance mapping can be used to identify and measure the activity of disease-related functional brain networks. While this approach has been widely used in the analysis of cerebral blood flow and metabolic PET scans, it is not clear whether it can be reliably applied to resting state functional MRI (rs-fMRI) data. In this study, we present a novel method based on independent component analysis (ICA) to characterize specific network topographies associated with Parkinson's disease (PD). Using rs-fMRI data from PD and healthy subjects, we used ICA with bootstrap resampling to identify a PD-related pattern that reliably discriminated the two groups. This topography, termed rs-MRI PD-related pattern (fPDRP), was similar to previously characterized disease-related patterns identified using metabolic PET imaging. Following pattern identification, we validated the fPDRP by computing its expression in rs-fMRI testing data on a prospective case basis. Indeed, significant increases in fPDRP expression were found in separate sets of PD and control subjects. In addition to providing a similar degree of group separation as PET, fPDRP values correlated with motor disability and declined toward normal with levodopa administration. Finally, we used this approach in conjunction with neuropsychological performance measures to identify a separate PD cognition-related pattern in the patients. This pattern, termed rs-fMRI PD cognition-related pattern (fPDCP), was topographically similar to its PET-derived counterpart. Subject scores for the fPDCP correlated with executive function in both training and testing data. These findings suggest that ICA can be used in conjunction with bootstrap resampling to identify and validate stable disease-related network topographies in rs-fMRI. Hum Brain Mapp 38:617-630, 2017. © 2016 Wiley Periodicals, Inc.
(出版サイトへのリンク): ● Publication site (DOI): 10.1002/hbm.23260
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27207613; ● Search Scopus @ Elsevier (PMID): 27207613; ● Search Scopus @ Elsevier (DOI): 10.1002/hbm.23260

(DOI: 10.1002/hbm.23260, PubMed: 27207613) Waka Sakai, Naoko Matsui, Mitsuyo Ishida, Takahiro Furukawa, Yoshimichi Miyazaki, Koji Fujita, Ryosuke Miyamoto, Nobuaki Yamamoto, Wataru Sako, Kenta Sato, Kazuya Kondo, Yoshihiko Nishida, Takao Mitsui, Yuishin Izumi and Ryuji Kaji :
Late-onset myasthenia gravis is predisposed to become generalized in the elderly,
eNeurologicalSci, Vol.2, 17-20, 2016.

(徳島大学機関リポジトリ): ● Metadata: 110923
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.ensci.2016.02.004
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1016/j.ensci.2016.02.004

(徳島大学機関リポジトリ: 110923, DOI: 10.1016/j.ensci.2016.02.004) Yoshimitsu Shimatani, Yuta Nakano, Naoko Tsuyama, Shigeo Murayama, Ryosuke Oki, Ryosuke Miyamoto, Nagahisa Murakami, Koji Fujita, Syunsuke Watanabe, Hisanori Uehara, Takashi Abe, Hiroyuki Nodera, Toshitaka Kawarai, Yuishin Izumi and Ryuji Kaji :
Extranodal NK/T-cell lymphoma, nasal type, manifesting as rapidly progressive dementia without any mass or enhancing brain lesion.,
Neuropathology, Vol.36, No.5, 456-463, 2016.

(要約): Among the many potential etiologies for rapidly progressive dementia (RPD), primary central nervous system extranodal NK/T-cell lymphoma, nasal-type (ENKL) is a rare entity. We present the first reported case of autopsy-proven RPD due to ENKL without any mass or enhancing lesion of the brain. A 54-year-old immunocompetent man presented with RPD, myoclonus and ataxia. The mini-mental state examination (MMSE) score was 22/30. His brain MRI revealed progressive brain atrophy without gadolinium enhancement or mass lesion. Five months after the initial evaluation, cognitive impairment further worsened with an MMSE score of 3/30. At the advanced stage, lumbar MRI showed swollen cauda equina with gadolinium enhancement. The number of Epstein-Barr virus (EBV) DNA in cerebrospinal fluid had gradually increased. Twelve months after onset, the patient died of respiratory failure. Pathological findings revealed that lymphoma cells had diffusely invaded the meninges, parenchyma of the brain, spinal cord and cauda equina. Cells were positive for CD3, CD56 and EBV-encoded small RNAs and negative for CD20. No evidence of malignancy was identified in the visceral organs. This report indicates that ENKL should be recognized as one of the rare causes of RPD. Early testing for EBV-DNA in cerebrospinal fluid and imaging of cauda equina would be useful diagnostic tools.
(キーワード): Brain / Brain Neoplasms / Cauda Equina / Dementia / Disease Progression / Humans / Immunocompetence / Lymphoma, Extranodal NK-T-Cell / Male / Middle Aged / Spinal Cord
(出版サイトへのリンク): ● Publication site (DOI): 10.1111/neup.12285
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26773724; ● Summary page in Scopus @ Elsevier: 2-s2.0-84989259948

(DOI: 10.1111/neup.12285, PubMed: 26773724, Elsevier: Scopus) Masaki Kamata, Shunya Nakane, Naoko Matsui, Osamu Higuchi, Sakai Waka, Koji Fujita, Yuishin Izumi, Hidenori Matsuo and Ryuji Kaji :
Ocular myasthenia gravis with anti-muscle-specific tyrosine kinase antibodies: Two new cases and a systematic literature review,
Clinical & Experimental Neuroimmunology, Vol.7, No.2, 168-173, 2016.

(出版サイトへのリンク): ● Publication site (DOI): 10.1111/cen3.12296
(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-84961266632

(DOI: 10.1111/cen3.12296, Elsevier: Scopus) Wataru Sako, Koji Fujita, An Vo, C Janet Rucker, John-Ross Rizzo, Martin Niethammer, Maren Carbon, B Susan Bressman, M Aziz Uluğ and David Eidelberg :
The visual perception of natural motion: abnormal task-related neural activity in DYT1 dystonia.,
Brain, Vol.138, No.Pt 12, 3598-3609, 2015.

(要約): Although primary dystonia is defined by its characteristic motor manifestations, non-motor signs and symptoms have increasingly been recognized in this disorder. Recent neuroimaging studies have related the motor features of primary dystonia to connectivity changes in cerebello-thalamo-cortical pathways. It is not known, however, whether the non-motor manifestations of the disorder are associated with similar circuit abnormalities. To explore this possibility, we used functional magnetic resonance imaging to study primary dystonia and healthy volunteer subjects while they performed a motion perception task in which elliptical target trajectories were visually tracked on a computer screen. Prior functional magnetic resonance imaging studies of healthy subjects performing this task have revealed selective activation of motor regions during the perception of 'natural' versus 'unnatural' motion (defined respectively as trajectories with kinematic properties that either comply with or violate the two-thirds power law of motion). Several regions with significant connectivity changes in primary dystonia were situated in proximity to normal motion perception pathways, suggesting that abnormalities of these circuits may also be present in this disorder. To determine whether activation responses to natural versus unnatural motion in primary dystonia differ from normal, we used functional magnetic resonance imaging to study 10 DYT1 dystonia and 10 healthy control subjects at rest and during the perception of 'natural' and 'unnatural' motion. Both groups exhibited significant activation changes across perceptual conditions in the cerebellum, pons, and subthalamic nucleus. The two groups differed, however, in their responses to 'natural' versus 'unnatural' motion in these regions. In healthy subjects, regional activation was greater during the perception of natural (versus unnatural) motion (P < 0.05). By contrast, in DYT1 dystonia subjects, activation was relatively greater during the perception of unnatural (versus natural) motion (P < 0.01). To explore the microstructural basis for these functional changes, the regions with significant interaction effects (i.e. those with group differences in activation across perceptual conditions) were used as seeds for tractographic analysis of diffusion tensor imaging scans acquired in the same subjects. Fibre pathways specifically connecting each of the significant functional magnetic resonance imaging clusters to the cerebellum were reconstructed. Of the various reconstructed pathways that were analysed, the ponto-cerebellar projection alone differed between groups, with reduced fibre integrity in dystonia (P < 0.001). In aggregate, the findings suggest that the normal pattern of brain activation in response to motion perception is disrupted in DYT1 dystonia. Thus, it is unlikely that the circuit changes that underlie this disorder are limited to primary sensorimotor pathways.
(出版サイトへのリンク): ● Publication site (DOI): 10.1093/brain/awv282
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26419798; ● Summary page in Scopus @ Elsevier: 2-s2.0-84951011957

(DOI: 10.1093/brain/awv282, PubMed: 26419798, Elsevier: Scopus) Ryosuke Miyamoto, Hiroyuki Sumikura, Toshiaki Takeuchi, Mitsuru Sanada, Koji Fujita, Toshitaka Kawarai, Hideo Mure, Ryoma Morigaki, Satoshi Goto, Shigeo Murayama, Yuishin Izumi and Ryuji Kaji :
Autopsy case of severe generalized dystonia and static ataxia with marked cerebellar atrophy.,
Neurology, Vol.85, No.17, 1522-1524, 2015.

(キーワード): Asphyxia / Atrophy / Autopsy / 脳 (brain) / Cerebellar Ataxia / 小脳 (cerebellum) / Dysphonia / Dystonic Disorders / Humans / 男性 (male) / Middle Aged / Prone Position
(出版サイトへのリンク): ● Publication site (DOI): 10.1212/WNL.0000000000002061
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26408497; ● Search Scopus @ Elsevier (PMID): 26408497; ● Search Scopus @ Elsevier (DOI): 10.1212/WNL.0000000000002061

(DOI: 10.1212/WNL.0000000000002061, PubMed: 26408497) Takahiro Furukawa, Naoko Matsui, Koji Fujita, Hiroyuki Nodera, Fumitaka Shimizu, Katsuichi Miyamoto, Yukitoshi Takahashi, Takashi Kanda, Susumu Kusunoki, Yuishin Izumi and Ryuji Kaji :
CSF cytokine profile distinguishes multifocal motor neuropathy from progressive muscular atrophy.,
Neurology® Neuroimmunology & Neuroinflammation, Vol.2, No.5, e138, 2015.

(要約): The CSF cytokine profile of patients with MMN is distinct from that of patients with PMA and ALS. The similarity of the cytokine profiles between patients with PMA and ALS suggests that PMA shares common immunologic features with ALS in the CNS, even without clinical evidence of upper motor neuron involvement.
(徳島大学機関リポジトリ): ● Metadata: 109981
(出版サイトへのリンク): ● Publication site (DOI): 10.1212/NXI.0000000000000138
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26280014; ● Search Scopus @ Elsevier (PMID): 26280014; ● Search Scopus @ Elsevier (DOI): 10.1212/NXI.0000000000000138

(徳島大学機関リポジトリ: 109981, DOI: 10.1212/NXI.0000000000000138, PubMed: 26280014) Takahiro Furukawa, Naoko Matsui, Koji Fujita, Ai Miyashiro, Hiroyuki Nodera, Yuishin Izumi, Fumitaka Shimizu, Katsuichi Miyamoto, Yukitoshi Takahashi, Takashi Kanda, Susumu Kusunoki and Ryuji Kaji :
Increased proinflammatory cytokines in sera of patients with multifocal motor neuropathy.,
Journal of the Neurological Sciences, Vol.346, No.1-2, 75-79, 2014.

(要約): Proinflammatory cytokines may contribute to peripheral nerve demyelination in MMN.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jns.2014.07.059
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25130929; ● Search Scopus @ Elsevier (PMID): 25130929; ● Search Scopus @ Elsevier (DOI): 10.1016/j.jns.2014.07.059

(DOI: 10.1016/j.jns.2014.07.059, PubMed: 25130929) 酒井和香, 松井尚子, 藤田浩司, 和泉唯信, 西田喜彦, 高橋利幸, 神林崇, 梶龍兒 :
抗利尿ホルモン分泌異常症候群で発症し，橋中心・橋外髄鞘崩壊症を合併した視神経脊髄炎関連疾患の1例,
臨床神経学, Vol.54, No.7, 556-560, 2014年.

(要約): A 36-year-old woman complained of general malaise. She presented with hyponatremia and plasma osmotic pressure was lower than urinary osmotic pressure. In addition, serum antidiuretic hormone level was higher than the measurement sensitivity. She was diagnosed with the syndrome of inappropriate antidiuretic hormone secretion (SIADH). She fell into a coma despite correction of serum sodium level. Brain magnetic resonance imaging (MRI) revealed high signal intensities in the cerebral cortex, striatum, thalamus, hypothalamus, midbrain, and pons in fluid-attenuated inversion recovery images. Spinal MRI revealed a longitudinally extending lesion in the cervical cord. Serum sample was positive for anti-aquaporin-4 antibody, supporting the diagnosis of neuromyelitis optica spectrum disorder (NMOSD) combined with central pontine and extrapontine myelinolysis. In patients with NMOSD, the immune reaction can gradually cause destructive changes of the hypothalamus and lead to unstable ADH secretion in the absence of immunomodulatory treatment.
(キーワード): Adult / Aquaporin 4 / Biomarkers / Brain / Humans / Inappropriate ADH Syndrome / Magnetic Resonance Imaging / Male / Methylprednisolone / Myelinolysis, Central Pontine / Neuromyelitis Optica / Plasma Exchange / Prednisolone / Pulse Therapy, Drug / Sodium / Treatment Outcome
(出版サイトへのリンク): ● Publication site (DOI): 10.5692/clinicalneurol.54.556
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25087556; ● Summary page in Scopus @ Elsevier: 2-s2.0-84906089774

(DOI: 10.5692/clinicalneurol.54.556, PubMed: 25087556, Elsevier: Scopus) 藤田浩司, 大崎祐亮, 宮本亮介, 安部孝志, 里見淳一郎 :
拡散強調画像で皮質直下に高信号を呈する白質脳症,
脳神経外科速報, Vol.24, No.3, 293-297, 2014年. Yoshiteru Tada, Junichiro Satomi, Takashi Abe, Kazuyuki Kuwayama, Shu Sogabe, Koji Fujita, Nobuaki Yamamoto, Ryuji Kaji, Masafumi Harada and Shinji Nagahiro :
Intra-arterial signal on arterial spin labeling perfusion MRI to identify the presence of acute middle cerebral artery occlusion,
Cerebrovascular Diseases, Vol.38, No.3, 191-196, 2014.

(要約): The susceptibility vessel sign on gradient echo-type-T2*-weighted imaging is a well-known marker of arterial occlusion. Stagnant flow in front of the middle cerebral artery (MCA) occlusion sites may contribute to the intra-arterial, high-intensity signal on arterial spin labeling magnetic resonance imaging (MRI), making it another potential marker of MCA occlusion. We compared the intra-arterial, high-intensity signal and susceptibility vessel sign in patients with symptomatic MCA occlusion and patients without major vessel occlusion. We identified transient ischemic attack or ischemic stroke patients with (1) 3-T MRI performed within 24 h after clinical onset including arterial spin labeling, T2*-weighted imaging, and magnetic resonance angiography (MRA) and (2) either having MCA occlusion (n = 34 patients) or without major vessel occlusion (n = 24 patients). The intra-arterial, high-intensity signal was defined as an enlarged circular or linear bright hyperintensity within the artery. The susceptibility vessel sign was defined as an enlarged spot of hypointensity within the MCA, in which the diameter of the hypointense signal within the vessel exceeded the contralateral vessel diameter. The presence or absence of the intra-arterial, high-intensity signal and susceptibility vessel sign were assessed, along with their inter-rater agreement and consistency with the presence of MCA occlusion on MRA. The intra-arterial, high-intensity signal was detectable in 30 patients (52%), and susceptibility vessel sign was observed in 17 patients (29%). The sensitivity of the intra-arterial high-intensity signal was significantly higher than that of the susceptibility vessel sign (88% vs. 50%; p < 0.05). The accuracy of the intra-arterial high-intensity signal was also higher than that of the susceptibility vessel sign (93% vs. 71%; p < 0.05). The intra-arterial high-intensity signal was situated in the proximal regions of the susceptibility vessel sign on T2*WI within the MCA. Neither the intra-arterial high-intensity signal nor the susceptibility vessel sign was observed in patients without major vessel occlusion. Inter-rater agreement was good for intra-arterial high-intensity signal detection (κ = 0.73) and moderate for susceptibility vessel sign detection (κ = 0.47). The presence or absence of the intra-arterial high-intensity signal was highly consistent with that of MCA occlusion on MRA (κ = 0.74). The intra-arterial high-intensity signal on arterial spin labeling appears to be useful to identify the presence of acute MCA occlusion and may be associated with stagnant flow in front of occlusion sites. The intra-arterial high-intensity signal may also be used to identify the occlusion site.
(キーワード): Aged / Aged, 80 and over / Cerebral Angiography / Female / Humans / Infarction, Middle Cerebral Artery / Ischemic Attack, Transient / Magnetic Resonance Angiography / 磁気共鳴映像法 (magnetic resonance imaging) / Male / Middle Aged / Middle Cerebral Artery / Sensitivity and Specificity / Stroke
(出版サイトへのリンク): ● Publication site (DOI): 10.1159/000365653
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25300901; ● Summary page in Scopus @ Elsevier: 2-s2.0-84912121647

(DOI: 10.1159/000365653, PubMed: 25300901, Elsevier: Scopus) Mungunkhuyag Majigusuren, Masafumi Harada, Takashi Abe, Koji Fujita, Naoko Matsui and Ryuji Kaji :
Longitudinal Monitoring with Multiple MR Techniques in a Case of Progressive Multifocal Leukoencephalopathy Associated with Multiple Myeloma,
Magnetic Resonance in Medical Sciences, Vol.13, No.1, 55-59, 2014.

(要約): Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the brain caused by the JC virus in immunocompromised patients. We report characteristic features of proton MR spectroscopy, 3-dimensional pseudo-continuous arterial spin labeling imaging, and diffusion tensor imaging in a 53-year-old patient with PML. The utility of multi-modal magnetic resonance techniques for longitudinal monitoring was indicated by their reevaluation over time and consideration of their relation to prognosis.
(キーワード): Disease Progression / Humans / Leukoencephalopathy, Progressive Multifocal / Magnetic Resonance Imaging / Male / Middle Aged / Multiple Myeloma
(出版サイトへのリンク): ● Publication site (DOI): 10.2463/mrms.2013-0037
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24492738; ● Summary page in Scopus @ Elsevier: 2-s2.0-84897898031

(DOI: 10.2463/mrms.2013-0037, PubMed: 24492738, Elsevier: Scopus) Nobuaki Yamamoto, Yuka Terasawa, Junichiro Satomi, Ryoma Morigaki, Koji Fujita, Yuishin Izumi, Shinji Nagahiro and Ryuji Kaji :
Reversibility of ischemic findings on 3-tesla magnetic resonance T2(*)-weighted image after recanalization,
The Journal of Medical Investigation : JMI, Vol.61, No.1,2, 190-196, 2014.

(要約): Ischemic vessel signs (IVS) can be detected on 3-tesla T2(*)-weighted magnetic resonance images as a vessel enlargement at the territory of acute ischemia caused by major vessel occlusion or stenosis. Here, we studied changes in IVS before and after recanalization by the administration of intravenous recombinant tissue plasminogen activator (IV rtPA), carotid artery stenting or percutaneous transluminal angioplasty in patients with major vessel occlusion or stenosis. We performed magnetic resonance imaging for all patients treated by IV rtPA at the time of admission, shortly after and 24-72 hours after treatment with IV rtPA. We reviewed the IVS to assess its natural course of IVS by assessing patients who did not recanalize. IVS tended to disappear after recanalization. Conversely, in patients without recanalization, IVS did not disappear shortly after IV rtPA; rather, it disappeared 24-72 hours after IV rtPA, especially in the presence of complete infarction. Recanalization by IV rtPA or endovascular treatment contributed to improved clinical deficits or the prevention from further progression. IVS can be a parameter of misery perfusion and an important factor to detect the patients who have an indication of treatment for recanalization.
(キーワード): Administration, Intravenous / Aged / Aged, 80 and over / Angioplasty / Carotid Arteries / Carotid Stenosis / Diffusion Magnetic Resonance Imaging / Disease Progression / Female / Humans / 虚血 (ischemia) / Male / Middle Aged / Retrospective Studies / Stents / Time Factors / Tissue Plasminogen Activator / Treatment Outcome
(徳島大学機関リポジトリ): ● Metadata: 109553
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.61.190
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24705765; ● Summary page in Scopus @ Elsevier: 2-s2.0-84897951917

(徳島大学機関リポジトリ: 109553, DOI: 10.2152/jmi.61.190, PubMed: 24705765, Elsevier: Scopus) Yuka Terasawa, Nobuaki Yamamoto, Ryoma Morigaki, Koji Fujita, Yuishin Izumi, Junichiro Satomi, Masafumi Harada, Shinji Nagahiro and Ryuji Kaji :
Brush sign on 3-T t2*-weighted MRI as a potential predictor of hemorrhagic transformation after tissue plasminogen activator therapy,
Stroke, Vol.45, No.1, 274-276, 2014.

(要約): The brush sign (BS) is the enlargement of medullary veins on 3-T T2*-weighted MRI seen in patients with ischemic stroke because of major cerebral artery occlusion. However, the clinical relevance of BS in patients with acute stroke remains unclear. We assessed the correlation between detecting BS with the development of hemorrhagic transformation after intravenous thrombolysis. We enrolled consecutive patients with M1 or M2 occlusion treated with intravenous tissue plasminogen activator. We classified the patients into 2 groups: the group positive for BS (P-BS) and the group negative for BS (N-BS). We investigated the differences in MRI findings and the clinical outcome between the 2 groups. The subjects consisted of 36 patients (19 men; mean age, 74.7 years). Twenty-one patients (58%) had M1 occlusion, and 15 (42%) had M2 occlusion. Twenty-five patients (69%) were classified into the P-BS group and 11 (31%) into the N-BS group. Recanalization was observed in 15 (60%) and 10 (90%) patients in the P-BS and N-BS groups, respectively (P=0.116). Hemorrhagic transformation on MRI was observed more frequently in the P-BS group than in the N-BS group (64% versus 18%; P=0.027). A good outcome (mRS, 0-1) at discharge was found in 24% of patients in the P-BS group and in 45% of patients in the N-BS group (P=0.152). A multivariate logistic regression analysis revealed that the presence of BS (odds ratio, 9.08; 95% confidence interval, 1.4-59.8; P=0.022) was independently associated with hemorrhagic transformation. BS may predict the development of hemorrhagic transformation in patients with acute stroke treated with intravenous tissue plasminogen activator.
(キーワード): Aged / Aged, 80 and over / Cerebral Hemorrhage / Disease Progression / Female / Fibrinolytic Agents / Humans / Image Processing, Computer-Assisted / Intracranial Embolism / Magnetic Resonance Imaging / Male / Middle Aged / Prognosis / Prospective Studies / Stroke / Thrombolytic Therapy / Tissue Plasminogen Activator / Treatment Outcome
(出版サイトへのリンク): ● Publication site (DOI): 10.1161/STROKEAHA.113.002640
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24172577; ● Summary page in Scopus @ Elsevier: 2-s2.0-85027928664

(DOI: 10.1161/STROKEAHA.113.002640, PubMed: 24172577, Elsevier: Scopus) Koji Fujita, Naoko Matsui, Yukitoshi Takahashi, Yasushi Iwasaki, Mari Yoshida, Tatsuhiko Yuasa, Yuishin Izumi and Ryuji Kaji :
Increased interleukin-17 in the cerebrospinal fluid in sporadic Creutzfeldt-Jakob disease: a case-control study of rapidly progressive dementia,
Journal of Neuroinflammation, Vol.10, 135, 2013.

(要約): Inflammatory responses in the cerebrospinal fluid (CSF) of patients with sporadic Creutzfeldt-Jakob disease (sCJD) remain elusive. We conducted a case-control study, in which 14 patients with sCJD, 14 with noninflammatory neurological disorders, and 14 with autoimmune encephalitis were enrolled. We used the suspension array system to measure the concentrations of 27 cytokines in CSF. The cytokine titers of the three groups were compared, and the correlation between the relevant cytokine titers and clinical parameters was investigated in the patients with sCJD. Levels of the two cytokines interleukin (IL)-1 receptor antagonist and IL-17 were significantly elevated in the patients with sCJD compared with those in the patients with noninflammatory neurological disorders: IL-17 levels in sCJD were approximately ten times higher than in the noninflammatory neurological disorders (mean, 35.46 vs. 3.45 pg/ml; P < 0.001) but comparable to that in encephalitis (mean, 32.16 pg/ml). In contrast, levels of classical proinflammatory cytokines such as IL-12(p70) and tumor necrosis factor-α were increased only in encephalitis. Although not significant, IL-17 titers tended to be higher in the patients with shorter disease duration before CSF sampling (r = -0.452; P = 0.104) and in those with lower CSF total protein concentrations (r = -0.473; P = 0.086). IL-17 is significantly increased in CSF in sCJD, which can be an early event in the pathogenesis of sCJD.
(キーワード): Aged / Case-Control Studies / Creutzfeldt-Jakob Syndrome / Dementia / Disease Progression / Female / Humans / Interleukin-17 / Male
(出版サイトへのリンク): ● Publication site (DOI): 10.1186/1742-2094-10-135
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24219883; ● Search Scopus @ Elsevier (PMID): 24219883; ● Search Scopus @ Elsevier (DOI): 10.1186/1742-2094-10-135

(DOI: 10.1186/1742-2094-10-135, PubMed: 24219883) Syunya Nakane, Koji Fujita, Yoshiko Shibuta, Naoko Matsui, Masafumi Harada, Ryo Urushihara, Yoshihiko Nishida, Yuishin Izumi and Ryuji Kaji :
Successful treatment of stiff person syndrome with sequential use of tacrolimus,
Journal of Neurology, Neurosurgery, and Psychiatry, Vol.84, No.10, 1177-1180, 2013.

(キーワード): Aged / Autoantibodies / Brain / Dose-Response Relationship, Drug / Drug Administration Schedule / Evoked Potentials, Motor / Female / Follow-Up Studies / Glutamate Decarboxylase / Humans / Immunosuppressive Agents / Magnetic Resonance Spectroscopy / Male / Middle Aged / Motor Cortex / Neurologic Examination / Stiff-Person Syndrome / Tacrolimus / Transcranial Magnetic Stimulation / gamma-Aminobutyric Acid
(出版サイトへのリンク): ● Publication site (DOI): 10.1136/jnnp-2013-305425
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23715915; ● Search Scopus @ Elsevier (PMID): 23715915; ● Search Scopus @ Elsevier (DOI): 10.1136/jnnp-2013-305425

(DOI: 10.1136/jnnp-2013-305425, PubMed: 23715915) Koji Fujita, W Sakai, Masafumi Harada, Mika Sakaki, Hideo Mure, Shinji Nagahiro, Yuishin Izumi and Ryuji Kaji :
Basal ganglia hyperintensity on T1-weighted imaging of a patient with central nervous system metastasis producing carcinoembryonic antigens,
Internal Medicine, Vol.52, No.3, 381-383, 2013.

(要約): We herein report unusual basal ganglia hyperintense lesions on noncontrast T1-weighted magnetic resonance imaging in a patient with central nervous system metastasis from lung adenocarcinoma that was treated with gefitinib. T2*-weighted magnetic resonance imaging showed no hypointense lesions, thereby excluding the possibility of calcification or haemorrhage. A stereotactic brain biopsy of the left basal ganglia lesions revealed atypical cells, some of which formed a glandular lumen with a micropapillary pattern. These cells were immunopositive for markers of lung adenocarcinoma, thereby confirming the diagnosis of metastasis. We speculate that proteins, including carcinoembryonic antigens from the adenocarcinoma cells in the basal ganglia, may have contributed to the hyperintensity observed on noncontrast T1-weighted magnetic resonance imaging.
(キーワード): Adenocarcinoma / Basal Ganglia / Brain Neoplasms / Carcinoembryonic Antigen / Female / Humans / Lung Neoplasms / Magnetic Resonance Imaging / Middle Aged
(出版サイトへのリンク): ● Publication site (DOI): 10.2169/internalmedicine.52.8835
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23370750; ● Summary page in Scopus @ Elsevier: 2-s2.0-84873503009

(DOI: 10.2169/internalmedicine.52.8835, PubMed: 23370750, Elsevier: Scopus) Koji Fujita, Yuishin Izumi, Masafumi Harada and Ryuji Kaji :
Crossed cerebellar hyperperfusion without restricted diffusion in status epilepticus.,
Journal of Neurology, Vol.260, No.2, 674-676, 2012.

(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s00415-012-6773-2
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23208665; ● Search Scopus @ Elsevier (PMID): 23208665; ● Search Scopus @ Elsevier (DOI): 10.1007/s00415-012-6773-2

(DOI: 10.1007/s00415-012-6773-2, PubMed: 23208665) 矢野祖, 西條敦郎, 近藤真代, 河野弘, 豊田優子, 柿内聡司, 岸潤, 埴淵昌毅, 古川貴大, 藤田浩司, 西岡安彦 :
神経根障害で発症した神経サルコイドーシスの一例,
四国医学雑誌, Vol.68, No.3,4, 153-158, 2012年.

(要約): A52-year-old woman was referred to our hospital for further examination of thoracolumbarpain. As dysesthesia at Th4level was seen in neurological examination, thoracic radiculopathy ormyelopathy was suspected. Blood examination showed elevated level of serum ACE and lysozyme.Lymphadenopathy was evident in bilateral hila and mediastina with marked FDG and Galliumaccumulation in FDG-PET-CT and Gallium scintigraphy, respectively. The number of lymphocytesand the CD4/CD8ratio were increased in the BALF. Histological findings of specimens obtainedfrom the lung and the skin lesion revealed noncaseating epithelioid granuloma, which yielded thediagnosis of sarcoidosis. The cerebrospinal fluid examinations showed elevated level of cell counts,proteins and β2-microglobulin. Taken together, she was diagnosed as neurosarcoidosis with thoracicradiculopathy. Her symptoms were improved with oral administration of prednisolone, butthey were exacerbated when prednisolone dose was tapered to20mg/day. Combined therapy ofmethotrexate and prednisolone was initiated, thereafter her symptoms disappeared completely.
(キーワード): neurosarcoidosis / radiculopathy / prednisolone / methotrexate
(徳島大学機関リポジトリ): ● Metadata: 102837
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1050845763842119680

(徳島大学機関リポジトリ: 102837, CiNii: 1050845763842119680) Hiroyuki Ishiura, Wataru Sako, Mari Yoshida, Toshitaka Kawarai, Osamu Tanabe, Jun Goto, Yuji Takahashi, Hidetoshi Date, Jun Mitsui, Budrul Ahsan, Yaeko Ichikawa, Atsushi Iwata, Hiide Yoshino, Yuishin Izumi, Koji Fujita, Kouji Maeda, Satoshi Goto, Hidetaka Koizumi, Ryoma Morigaki, Masako Ikemura, Naoko Yamauchi, Shigeo Murayama, A Garth Nicholson, Hidefumi Ito, Gen Sobue, Masanori Nakagawa, Ryuji Kaji and Shoji Tsuji :
The TRK-fused gene is mutated in hereditary motor and sensory neuropathy with proximal dominant involvement.,
American Journal of Human Genetics, Vol.91, No.2, 320-329, 2012.

(要約): Hereditary motor and sensory neuropathy with proximal dominant involvement (HMSN-P) is an autosomal-dominant neurodegenerative disorder characterized by widespread fasciculations, proximal-predominant muscle weakness, and atrophy followed by distal sensory involvement. To date, large families affected by HMSN-P have been reported from two different regions in Japan. Linkage and haplotype analyses of two previously reported families and two new families with the use of high-density SNP arrays further defined the minimum candidate region of 3.3 Mb in chromosomal region 3q12. Exome sequencing showed an identical c.854C>T (p.Pro285Leu) mutation in the TRK-fused gene (TFG) in the four families. Detailed haplotype analysis suggested two independent origins of the mutation. Pathological studies of an autopsied patient revealed TFG- and ubiquitin-immunopositive cytoplasmic inclusions in the spinal and cortical motor neurons. Fragmentation of the Golgi apparatus, a frequent finding in amyotrophic lateral sclerosis, was also observed in the motor neurons with inclusion bodies. Moreover, TAR DNA-binding protein 43 kDa (TDP-43)-positive cytoplasmic inclusions were also demonstrated. In cultured cells expressing mutant TFG, cytoplasmic aggregation of TDP-43 was demonstrated. These findings indicate that formation of TFG-containing cytoplasmic inclusions and concomitant mislocalization of TDP-43 underlie motor neuron degeneration in HMSN-P. Pathological overlap of proteinopathies involving TFG and TDP-43 highlights a new pathway leading to motor neuron degeneration.
(キーワード): Base Sequence / Chromosomes, Human, Pair 3 / DNA-Binding Proteins / Exome / Genetic Linkage / Genetic Predisposition to Disease / Golgi Apparatus / Haplotypes / Hereditary Sensory and Motor Neuropathy / Humans / Inclusion Bodies / 日本 (Japan) / Molecular Sequence Data / Motor Neurons / Pedigree / Point Mutation / Polymorphism, Single Nucleotide / Proteins / Sequence Analysis, DNA
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.ajhg.2012.07.014
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22883144; ● Search Scopus @ Elsevier (PMID): 22883144; ● Search Scopus @ Elsevier (DOI): 10.1016/j.ajhg.2012.07.014

(DOI: 10.1016/j.ajhg.2012.07.014, PubMed: 22883144) Koji Fujita, Tatsuhiko Yuasa, Yukitoshi Takahashi, Keiko Tanaka, Wataru Sako, Hidetaka Koizumi, Yasushi Iwasaki, Mari Yoshida, Yuishin Izumi and Ryuji Kaji :
Antibodies to N-methyl-D-aspartate glutamate receptors in Creutzfeldt-Jakob disease patients.,
Journal of Neuroimmunology, Vol.251, No.1-2, 90-93, 2012.

(要約): Psychiatric symptom can be a prominent feature early in Creutzfeldt-Jakob disease (CJD), which is also common in autoantibody-mediated limbic encephalitis. We hypothesized that anti-neuronal autoantibodies, especially those against N-methyl-D-aspartate glutamate receptors (NMDAR), can also be associated with CJD. Thirteen patients with CJD and 13 patients with limbic encephalitis were enrolled. Immunohistochemistry demonstrated that serum of CJD patients reacted with neuronal components of the rat hippocampus, indicating that those samples contained anti-neuronal antibodies. Enzyme-linked immunosorbent assay revealed that titers of antibodies against peptides of GluN2B subunit of NMDAR were significantly elevated in the serum and cerebrospinal fluid of CJD patients.
(キーワード): Aged / Aged, 80 and over / Animals / Autoantibodies / Creutzfeldt-Jakob Syndrome / 女性 (female) / Hippocampus / Humans / Limbic Encephalitis / 男性 (male) / Middle Aged / Rats / Receptors, N-Methyl-D-Aspartate
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jneuroim.2012.06.010
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22809875; ● Summary page in Scopus @ Elsevier: 2-s2.0-84865619727

(DOI: 10.1016/j.jneuroim.2012.06.010, PubMed: 22809875, Elsevier: Scopus) Kotaro Ogaki, Yuanzhe Li, Naoki Atsuta, Hiroyuki Tomiyama, Manabu Funayama, Hazuki Watanabe, Ryoichi Nakamura, Hideo Yoshino, Seiji Yato, Asako Tamura, Yutaka Naito, Akira Taniguchi, Koji Fujita, Yuishin Izumi, Ryuji Kaji, Nobutaka Hattori and Gen Sobue :
Analysis of C9orf72 repeat expansion in 563 Japanese patients with amyotrophic lateral sclerosis.,
Neurobiology of Aging, Vol.33, No.10, 2527.e11-6, 2012.

(要約): Recently, a hexanucleotide repeat expansion in C9orf72 was identified as the most common cause of both sporadic and familial amyotrophic lateral sclerosis (ALS) and frontotemporal dementia in Western populations. We analyzed 563 Japanese patients with ALS (552 sporadic and 11 familial) using fluorescent fragment-length analysis of C9orf72 and repeat-primed polymerase chain reaction analysis. Haplotype analysis was performed for 42 single nucleotide polymorphisms in patients with C9orf72 repeat expansion. C9orf72 repeat expansion was found in 2 patients with sporadic ALS (2/552 = 0.4%) and no patients with familial ALS (0/11 = 0%). In the probands' families, 1 primary progressive aphasia patient and 1 asymptomatic 76-year-old individual exhibited C9orf72 repeat expansion. All of the patients with the C9orf72 repeat expansion carried the 20-single nucleotide polymorphism consensus risk haplotype. The frequency of the C9orf72 repeat expansion among Japanese patients is much lower than in Western populations. The existence of a 76-year-old asymptomatic carrier supported the notion of incomplete penetrance. The C9orf72 mutation should be analyzed in sporadic ALS patients after determining their family histories not only of frontotemporal dementia but also of primary progressive aphasia.
(キーワード): Adult / Age of Onset / Aged / Aged, 80 and over / Amyotrophic Lateral Sclerosis / Asian Continental Ancestry Group / DNA Repeat Expansion / Female / Gene Frequency / Haplotypes / Humans / Male / Middle Aged / Mutation / Neuropsychological Tests / Penetrance / Polymorphism, Single Nucleotide / Proteins
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.neurobiolaging.2012.05.011
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22727276; ● Search Scopus @ Elsevier (PMID): 22727276; ● Search Scopus @ Elsevier (DOI): 10.1016/j.neurobiolaging.2012.05.011

(DOI: 10.1016/j.neurobiolaging.2012.05.011, PubMed: 22727276) Yuka Terasawa, Koji Fujita, Yuishin Izumi and Ryuji Kaji :
Early detection of familial Creutzfeldt-Jakob disease on diffusion-weighted imaging before symptom onset.,
Journal of the Neurological Sciences, Vol.319, No.1-2, 130-132, 2012.

(要約): Familial Creutzfeldt-Jakob disease (CJD) with V180I shows different clinical characteristics from classical CJD and is difficult to diagnose in the early stage. We report a CJD180 patient in whom results of diffusion-weighted imaging (DWI) led us to suspect CJD before symptoms started. A 68-year-old woman presented to our hospital with headache and nausea and underwent magnetic resonance imaging. DWI showed cortical hyperintensity. Three months later, cognitive function started to decline and CJD180 was diagnosed following genetic examination. In the early stage, ADC values were not decreased and single positron emission computed tomography demonstrated a decreased pattern like Alzheimer disease.
(キーワード): Aged / Brain / Creutzfeldt-Jakob Syndrome / Diffusion Magnetic Resonance Imaging / Disease Progression / Early Diagnosis / Female / Headache / Humans / Nausea
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jns.2012.04.004
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22640903; ● Search Scopus @ Elsevier (PMID): 22640903; ● Search Scopus @ Elsevier (DOI): 10.1016/j.jns.2012.04.004

(DOI: 10.1016/j.jns.2012.04.004, PubMed: 22640903) Koji Fujita, Tatsuhiko Yuasa, Osamu Watanabe, Yukitoshi Takahashi, Shuji Hashiguchi, Katsuhito Adachi, Yuishin Izumi and Ryuji Kaji :
Voltage-gated potassium channel complex antibodies in Creutzfeldt-Jakob disease.,
Journal of Neurology, Vol.259, No.10, 2249-2250, 2012.

(キーワード): Autoantibodies / Autoantigens / Creutzfeldt-Jakob Syndrome / Humans / 男性 (male) / Middle Aged / Potassium Channels, Voltage-Gated
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s00415-012-6554-y
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22638567; ● Search Scopus @ Elsevier (PMID): 22638567; ● Search Scopus @ Elsevier (DOI): 10.1007/s00415-012-6554-y

(DOI: 10.1007/s00415-012-6554-y, PubMed: 22638567) Koji Fujita, Masafumi Harada, Makoto Sasaki, Tatsuhiko Yuasa, Kenji Sakai, Tsuyoshi Hamaguchi, Nobuo Sanjo, Yusei Shiga, Katsuya Satoh, Ryuichiro Atarashi, Susumu Shirabe, Ken Nagata, Tetsuya Maeda, Shigeo Murayama, Yuishin Izumi, Ryuji Kaji, Masahito Yamada and Hidehiro Mizusawa :
Multicentre multiobserver study of diffusion-weighted and fluid-attenuated inversion recovery MRI for the diagnosis of sporadic Creutzfeldt-Jakob disease: a reliability and agreement study.,
BMJ Open, Vol.2, No.1, 649, 2012.

(要約): Objectives To assess the utility of the display standardisation of diffusion-weighted MRI (DWI) and to compare the effectiveness of DWI and fluid-attenuated inversion recovery (FLAIR) MRI for the diagnosis of sporadic Creutzfeldt-Jakob disease (sCJD). Design A reliability and agreement study. Setting Thirteen MRI observers comprising eight neurologists and five radiologists at two universities in Japan. Participants Data of 1.5-Tesla DWI and FLAIR were obtained from 29 patients with sCJD and 13 controls. Outcome measures Standardisation of DWI display was performed utilising b0 imaging. The observers participated in standardised DWI, variable DWI (the display adjustment was observer dependent) and FLAIR sessions. The observers independently assessed each MRI for CJD-related lesions, that is, hyperintensity in the cerebral cortex or striatum, using a continuous rating scale. Performance was evaluated by the area under the receiver operating characteristics curve (AUC). Results The mean AUC values were 0.84 (95% CI 0.81 to 0.87) for standardised DWI, 0.85 (95% CI 0.82 to 0.88) for variable DWI and 0.68 (95% CI 0.63 to 0.72) for FLAIR, demonstrating the superiority of DWI (p<0.05). There was a trend for higher intraclass correlations of standardised DWI (0.74, 95% CI 0.66 to 0.83) and variable DWI (0.72, 95% CI 0.62 to 0.81) than that of FLAIR (0.63, 95% CI 0.53 to 0.74), although the differences were not statistically significant. Conclusions Standardised DWI is as reliable as variable DWI, and the two DWI displays are superior to FLAIR for the diagnosis of sCJD. The authors propose that hyperintensity in the cerebral cortex or striatum on 1.5-Tesla DWI but not FLAIR can be a reliable diagnostic marker for sCJD.
(徳島大学機関リポジトリ): ● Metadata: 114896
(出版サイトへのリンク): ● Publication site (DOI): 10.1136/bmjopen-2011-000649
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22290397; ● Search Scopus @ Elsevier (PMID): 22290397; ● Search Scopus @ Elsevier (DOI): 10.1136/bmjopen-2011-000649

(徳島大学機関リポジトリ: 114896, DOI: 10.1136/bmjopen-2011-000649, PubMed: 22290397) Koji Fujita, Tatsuhiko Yuasa, Yukitoshi Takahashi, Keiko Tanaka, Shuji Hashiguchi, Katsuhito Adachi, Yuishin Izumi and Ryuji Kaji :
Detection of anti-glutamate receptor 2 and anti-N-methyl-D: -aspartate receptor antibodies in a patient with sporadic Creutzfeldt-Jakob disease.,
Journal of Neurology, Vol.259, No.5, 985-988, 2011.

(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s00415-011-6291-7
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22057403; ● Search Scopus @ Elsevier (PMID): 22057403; ● Search Scopus @ Elsevier (DOI): 10.1007/s00415-011-6291-7

(DOI: 10.1007/s00415-011-6291-7, PubMed: 22057403) Wataru Sako, Hidefumi Ito, Mari Yoshida, Hidetaka Koizumi, Masaki Kamada, Koji Fujita, Yoshio Hashizume, Yuishin Izumi and Ryuji Kaji :
Nuclear factor B expression in patients with sporadic amyotrophic lateral sclerosis and hereditary amyotrophic lateral sclerosis with optineurin mutations,
Clinical Neuropathology, Vol.31, No.6, 418-423, 2011.

(要約): Nuclear factor κ B (NF-κB) is involved in the pathogenesis of a number of neurodegenerative disorders with neuroinflammation. In order to clarify the role of NF-κB in ALS, immunohistochemical studies with an antibody that recognizes the p65 subunit of NF-κB were performed on the spinal anterior horn of 4 patients with sporadic ALS (sALS), 1 patient with optineurin-mutated ALS (OPTN-ALS), and 3 normal controls (NC). In patients with sALS or OPTN-ALS, the expression pattern of NF-κB was altered when compared to that of NC; NF-κB immunoreactivity tended to be absent from neuronal nucleus and was increased in microglia. The down-regulation of NF-κB in neuronal nucleus might contribute to a loss of neuroprotection, or neurons with nuclear NF-κB might be lost immediately after its activation. The microglial induction of NF-κB might contribute to neuroinflammation. In conclusion, NF-κB signaling pathway could have a key role in the pathomechanism of ALS.
(キーワード): Aged / Aged, 80 and over / Amyotrophic Lateral Sclerosis / Blotting, Western / Female / Humans / 免疫組織化学 (immunohistochemistry) / Male / Middle Aged / NF-kappa B / 脊髄 (spinal cord) / Transcription Factor TFIIIA
(出版サイトへのリンク): ● Publication site (DOI): 10.5414/NP300493
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22762947; ● Summary page in Scopus @ Elsevier: 2-s2.0-84871831437

(DOI: 10.5414/NP300493, PubMed: 22762947, Elsevier: Scopus) Koji Fujita, Yoshitaka Yamaguchi, Tsuyoshi Mori, Naomi Muramatsu, Takahito Miyamoto, Masashi Yano, Hironori Miyata, Akira Ootsuyama, Makoto Sawada, Haruo Matsuda, Ryuji Kaji and Suehiro Sakaguchi :
Effects of a Brain-Engraftable Microglial Cell Line Expressing Anti-Prion scFv Antibodies on Survival Times of Mice Infected with Scrapie Prions.,
Cellular and Molecular Neurobiology, Vol.31, No.7, 999-1008, 2011.

(要約): We first verified that a single chain Fv fragment against prion protein (anti-PrP scFv) was secreted by HEK293T cells and prevented prion replication in infected cells. We then stably expressed anti-PrP scFv in brain-engraftable murine microglial cells and intracerebrally injected these cells into mice before or after infection with prions. Interestingly, the injection before or at an early time point after infection attenuated the infection marginally but significantly prolonged survival times of the mice. These suggest that the ex vivo gene transfer of anti-PrP scFvs using brain-engraftable cells could be a possible immunotherapeutic approach against prion diseases.
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s10571-011-9696-z
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21516351; ● Search Scopus @ Elsevier (PMID): 21516351; ● Search Scopus @ Elsevier (DOI): 10.1007/s10571-011-9696-z

(DOI: 10.1007/s10571-011-9696-z, PubMed: 21516351) Koji Fujita, Masafumi Harada, Tatsuhiko Yuasa, Makoto Sasaki, Yuishin Izumi and Ryuji Kaji :
Temporal evolution of sporadic Creutzfeldt-Jakob disease monitored by 3-Tesla MR spectroscopy.,
Journal of Neurology, Vol.258, No.7, 1368-1370, 2011.

(キーワード): Aged / Aspartic Acid / Choline / Creutzfeldt-Jakob Syndrome / Disease Progression / 女性 (female) / Humans / Magnetic Resonance Spectroscopy / 男性 (male)
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s00415-011-5939-7
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21327850; ● Search Scopus @ Elsevier (PMID): 21327850; ● Search Scopus @ Elsevier (DOI): 10.1007/s00415-011-5939-7

(DOI: 10.1007/s00415-011-5939-7, PubMed: 21327850) 古北一泰, 久保宜明, 福本大輔, 飛田泰斗史, 荒瀬誠治, 藤田浩司 :
Isaacs症候群を合併し難治であったびまん性筋膜炎の1例,
皮膚科の臨床, Vol.52, No.3, 413-417, 2010年.

(キーワード): 筋電図
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1522825130223060992

(CiNii: 1522825130223060992) 河北直也, 藤田浩司, 三ツ井貴夫, 和泉唯信, 鈴江淳彦, 宇野昌明, 佐藤浩一, 永廣信治, 山田博胤, 森田奈緒美, 梶龍兒 :
3 Tesla T2 *強調MRIで中大脳動脈内塞栓子を呈した若年性脳塞栓症の1例,
脳卒中, Vol.29, No.3, 469-473, 2007年.

(キーワード): cerebral embolism / 3 Tesla T2^*-weighted image / patent foramen ovale / atrial septal aneurysm
(出版サイトへのリンク): ● Publication site (DOI): 10.3995/jstroke.29.469
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1573387451037736320; ● Search Scopus @ Elsevier (DOI): 10.3995/jstroke.29.469

(DOI: 10.3995/jstroke.29.469, CiNii: 1573387451037736320) 宇野昌明, 原田雅史, 森田奈緒美, 西京子, 松原俊二, 中根俊成, 和泉唯信, 藤田浩司, 永廣信治 :
3T-MRIによるstroke MRIの有用性と問題点,
脳卒中, Vol.29, No.6, 824-829, 2007年.

(出版サイトへのリンク): ● Publication site (DOI): 10.3995/jstroke.29.824
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.3995/jstroke.29.824

(DOI: 10.3995/jstroke.29.824)

MISC

Yuki Matsumoto, Koji Fujita, Masafumi Harada, Yuki Kanazawa and Miyoshi Mitsuharu :
Characterization of Movement Disorders Using Multimodal Neuroimaging,
European Congress of Radiology (EPOS), 2022.

(出版サイトへのリンク): ● Publication site (DOI): 10.26044/ecr2022/C-16595
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.26044/ecr2022/C-16595

(DOI: 10.26044/ecr2022/C-16595) 藤田浩司, 大崎裕亮, 阿部考志, 原田雅史, 梶隆兒 :
T2*強調画像における脳実質・脳表の低信号,
脳神経外科速報, Vol.25, No.1, 38-42, 2015年. 宮﨑由道, 松井尚子, 藤田浩司, 阿部考志, 高橋利幸, 原田雅史 :
脳室周囲および延髄背側の病変,
脳神経外科速報, Vol.24, No.10, 1100-1105, 2014年. 大崎裕亮, 藤田浩司, 瓦井俊孝, 寺澤由佳, 乾俊夫, 阿部考志 :
年単位で持続する大脳白質の拡散強調画像高信号,
脳神経外科速報, Vol.24, No.9, 980-986, 2014年. 平井聡, 桑山一行, 多田恵曜, 里見淳一郎, 阿部考志, 藤田浩司 :
T2*強調画像における脳静脈洞，皮質静脈の低信号病変,
脳神経外科速報, Vol.24, No.7, 700-704, 2014年. 沖良祐, 藤田浩司, 庄野健児, 里見淳一郎, 阿部考志 :
大脳白質・線条体に相次いで出現する拡散低下,
脳神経外科速報, Vol.24, No.5, 528-531, 2014年. 大崎裕亮, 藤田浩司, 阿部考志, 梶隆兒 :
大脳基底核における左右対称の浮腫性病変,
脳神経外科速報, Vol.24, No.4, 400-403, 2014年. Toshio Inui, Toshitaka Kawarai, Koji Fujita, Kazuyuki Kawamura, Takao Mitsui, Antonio Orlacchio, Masaki Kamada, Takashi Abe, Yuishin Izumi and Ryuji Kaji :
A new CSF1R mutation presenting with an extensive white matter lesion mimicking primary progressive multiple sclerosis.,
Journal of the Neurological Sciences, 2013.

(要約): HDLS (Hereditary Diffuse Leukodystrophy with Spheroids) is a hereditary leukodystrophy whose main clinical manifestations include parkinsonism, spasticity, and ataxia. Genetic defects in the colony-stimulating factor 1 receptor (CSF1R) gene have been reported in many HDLS cases. The present report describes a new missense mutation Arg777Gln involving exon 18 of the CSF1R gene in a sporadic patient presenting with tumor-like lesions mimicking primary progressive multiple sclerosis. The patient was initially diagnosed with a progressive variant of multiple sclerosis and received inadequate treatments. Although most HDLS cases have a positive family history, this disease should also be suspected in sporadic patients showing unusual white matter lesions at MRI.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jns.2013.08.020
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24034409; ● Search Scopus @ Elsevier (PMID): 24034409; ● Search Scopus @ Elsevier (DOI): 10.1016/j.jns.2013.08.020

(DOI: 10.1016/j.jns.2013.08.020, PubMed: 24034409) Koji Fujita, Mari Yoshida, Wataru Sako, Kouji Maeda, Yoshio Hashizume, Satoshi Goto, Gen Sobue, Yuishin Izumi and Ryuji Kaji :
Brainstem and spinal cord motor neuron involvement with optineurin inclusions in proximal-dominant hereditary motor and sensory neuropathy,
Journal of Neurology, Neurosurgery, and Psychiatry, Vol.82, No.12, 1402-1403, 2011.

(キーワード): Brain Stem / Hereditary Sensory and Motor Neuropathy / Humans / Inclusion Bodies / 男性 (male) / Middle Aged / Motor Neurons / 脊髄 (spinal cord) / Transcription Factor TFIIIA
(出版サイトへのリンク): ● Publication site (DOI): 10.1136/jnnp-2011-300783
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21836032; ● Summary page in Scopus @ Elsevier: 2-s2.0-80855123814

(DOI: 10.1136/jnnp-2011-300783, PubMed: 21836032, Elsevier: Scopus)

総説・解説

沖良祐, 藤田浩司, 和泉唯信, 梶龍兒 :
高用量メチルコバラミン,
難病と在宅ケア, Vol.27, No.4, 10-14, 2021年7月.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1521417756163133440

(CiNii: 1521417756163133440) 和泉唯信, 藤田浩司 :
筋萎縮性側索硬化症(ALS)治療の現状と目指すべきもの,
難病と在宅ケア, Vol.27, No.4, 5-9, 2021年7月.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1524232505930155904

(CiNii: 1524232505930155904) 藤田浩司, 山本雄貴, 山本伸昭 :
放射線科医が知っておくべき脳血管障害診療 update】特殊な脳血管障害の診断 CADASIL,CARASIL, 悪性腫瘍に伴う脳梗塞,血管炎,脳アミロイド血管症,
臨床画像, Vol.36, 92-103, 2020年4月.

(出版サイトへのリンク): ● Publication site (DOI): 10.18885/ci.0000000269
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390572174450972800; ● Search Scopus @ Elsevier (DOI): 10.18885/ci.0000000269

(DOI: 10.18885/ci.0000000269, CiNii: 1390572174450972800) 和泉唯信, 島かさ音, 藤田浩司 :
神経疾患治療ノートビタミンB12欠乏,
Clinical Neuroscience, Vol.38, No.4, 510-512, 2020年. Koji Fujita and David Eidelberg :
Imbalance of the direct and indirect pathways in focal dystonia: a balanced view.,
Brain, Vol.140, No.12, 3075-3077, Dec. 2017.

(キーワード): Basal Ganglia / Dystonic Disorders / Humans
(出版サイトへのリンク): ● Publication site (DOI): 10.1093/brain/awx305
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29194506; ● Search Scopus @ Elsevier (PMID): 29194506; ● Search Scopus @ Elsevier (DOI): 10.1093/brain/awx305

(DOI: 10.1093/brain/awx305, PubMed: 29194506) 宮﨑由道, 松井尚子, 藤田浩司, 阿部考志, 高橋利幸, 原田雅史, 梶龍兒 :
見逃し危険!MRIで迫る中枢神経疾患の画像診断(第8回) 脳室周囲および延髄背側の病変心因性障害と考えられていた39歳女性,
脳神経外科速報, Vol.24, No.10, 1094-1099, 2014年.

(要約): <Key Points>(1)視神経炎や脊髄炎を呈し，脳室周囲や延髄背側の病変，3椎体以上の長い脊髄病変を見たときはNMO spectrum disorderを疑い，抗AQP4抗体を検査する．(2)NMO spectrum disorderの急性期はステロイドパルスや血漿交換を行い，再発予防はプレドニゾロンが第一選択である．(著者抄録)
(キーワード): Prednisolone(治療的利用) 延髄(画像診断) 血漿交換 *MRI *視神経脊髄炎(画像診断,薬物療法,治療) 鑑別診断多発性硬化症脳室(画像診断) 心因性疾患ヒト成人(19~44) 女

藤田浩司, 和泉唯信, 梶龍兒 :
[Inflammatory mechanisms in amyotrophic lateral sclerosis].,
脳と神経 - 神経研究の進歩, Vol.64, No.3, 273-278, 2012年3月.

(要約): Neuroinflammation is a pathological hallmark in human amyotrophic lateral sclerosis (ALS) patients and in the transgenic models of the disease. The importance of glial cell activation and pro-inflammatory cytokines in ALS has been confirmed by numerous studies. For instance, tumor necrosis factor- (TNF-), a major pro-inflammatory cytokine, activates microglia and cause neurotoxicity in motor neurons. More recently, the relationship of nuclear factor-B (NF-B) and motor neuron degeneration has garnered attention since optineurin (OPTN) mutations were reported in familial ALS. OPTN negatively regulates TNF--induced NF-B activation, but OPTN mutations can lead to dysinhibition of NF-B-induced neurotoxicity. Notably, OPTN-positive inclusions are observed not only in familial ALS with OPTN mutation but also in sporadic ALS and in familial ALS with SOD1 and fused in sarcoma mutations, suggesting that OPTN- and NF-B-related pathways are relevant to the general pathomechanisms of ALS. In this review, we discuss inflammatory aspects of ALS comprising the roles of cytokines, glial cells, and T cells.
(キーワード): Amyotrophic Lateral Sclerosis / Animals / Chemokines / 細胞質分裂 (cytokinesis) / Humans / 炎症 (inflammation) / NF-kappa B / Transcription Factor TFIIIA
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22402721; ● Search Scopus @ Elsevier (PMID): 22402721

(PubMed: 22402721)

講演・発表

Shotaro Haji, Koji Fujita, Ryosuke Oki, Yusuke Osaki, Hiroyuki Morino, S Nagano, N Atsuta, Y Kanazawa, Y Matsumoto, A Arisawa, H Kawai, S Sakaguchi, K Yagi, T Hamatani, M Harada, G Sobue and Yuishin Izumi :
An Exploratoruy Trial of EPI-589 in Amyotrophic Lateral Sclerosis (EPIC-ALS),
Pan-Asian Consortium for Treatment and Research in ALS (PACTALS), Kuala Lumpur, Sep. 2023. Kyohei Maekawa, Satoru Kohno, Yuki Matsumoto, Masafumi Harada and Koji Fujita :
Imaging biomarker in Prodromal Parkinson's disease using a novel network index of resting state fMRI,
29th Annual Meeting of The Organization for Human Brain Mapping,Montréal, Canada, Jul. 2023.

(キーワード): fMRI / Parkinson's disease / Imaging biomarker / brain network

Yuki Matsumoto, Koji Fujita, Masafumi Harada, Yuki Kanazawa and Miyoshi Mitsuharu :
Characterization of Movement Disorders Using Multimodal Neuroimaging,
European Congress of Radiology, Wien, Mar. 2022. Inoue Haruhisa, Imamura Keiko, Yuishin Izumi, Nagai Makiko, Nishiyama Kazutoshi, Watanabe Yasuhiro, Hanajima Ritsuko, Egawa Naohiro, Ayaki Takashi, Oki Ryosuke, Koji Fujita, Morinaga Akiko, Hirohashi Tomoko, Fujii Yosuke, Uozumi Ryuji, Morita Satoshi and Takahashi Ryosuke :
A phase I dose escalation study of bosutinib for amyotrophic lateral sclerosis: Induced pluripotent stem cell-based Drug Repurposing for Amyotrophic Lateral Sclerosis Medicine (iDReAM) study,
XXV World Congress of Neurology, Oct. 2021. Shotaro Haji, R Oki, Koji Fujita, Yusuke Osaki, S Nagano, N Atsuta, Y Kanazawa, Y Matsumoto, A Arisawa, H Kawai, Y Sato, S Sakaguchi, K Yaki, T Hamatani, Hiroaki Yanagawa, Masafumi Harada, G Sobue and Yuishin Izumi :
EPI-589 early phase 2 investigator-initiated clinical trial for ALS (EPIC-ALS): protocol for an exploratory study,
Pan-Asia Consortium for Treatment and Research in ALS (PACTALS) 2021 NAGOYA, Nagoya, Sep. 2021. R Oki, Yuishin Izumi, Koji Fujita, Y Sato, S Sakaguchi, K Yagi, A Matsushita, K Maeda, Hiroaki Yanagawa and Ryuji Kaji :
Management of phase 3 clinical trial for ALS during the COVID-19 pandemic,
Pan-Asia Consortium for Treatment and Research in ALS (PACTALS) 2021 NAGOYA, Nagoya, Sep. 2021. Satoru Kohno, Daisuke Sato, Sumida Nami, Yuki Matsumoto, Masafumi Harada and Koji Fujita :
Radial Correlation and Radial Similarity Contrast Reveal Abnormal Brain Networks in Dystonia,
27th Annual Meeting of The Organization for Human Brain Mapping, web conference, Jun. 2021. Naoko Matsui, Takahiro Furukawa, Koji Fujita, Hiroyuki Nodera, Fumitaka Shimizu, Katsuichi Miyamoto, Yukitoshi Takahashi, Takashi Kanda, Susumu Kusunoki, Yuishin Izumi and Ryuji Kaji :
CSF cytokine profile distinguishes multifocal motor neuropathy from progressive muscular atrophy,
1st Asia-Pacific School of Neuroimmunology, Vol.2, No.5, e138, Tokyo, Aug. 2015.

(出版サイトへのリンク): ● Publication site (DOI): 10.1212/NXI.0000000000000138
(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-85011964802

(DOI: 10.1212/NXI.0000000000000138, Elsevier: Scopus) Nobuaki Yamamoto, Yuka Terasawa, Junichiro Satomi, Ryoma Morigaki, Koji Fujita, Masafumi Harada, Yuishin Izumi, Shinji Nagahiro and Ryuji Kaji :
Reversibility of ischemic findings on 3-tesla magnetic resonance T2*-weighted image after recanalization,
European Stroke Conference 2014, Nice, France, May 2014. 木原直輝, 宮本亮介, 橘このか, 松原知康, 藤田浩司, 森野豊之, 和泉唯信 :
異常行動，失文法を呈しCSF1R 遺伝子の新規バリアントを認めたALSP/HDLSの1例,
第115回日本神経学会中国・四国地方会, 2024年6月. 前川恭平, 河野理, 松元友暉, 藤田浩司, 原田雅史 :
極座標系Radial Correlation Contrastを用いた脳神経疾患の安静時fMRI解析,
第26回日本ヒト脳機能マッピング学会, 2024年2月. 木原直輝, 山﨑博輝, 黒田一駿, 福本竜也, 松原知康, 土師正太郎, 宮本亮介, 山本伸昭, 藤田浩司, 松井尚子, 和泉唯信 :
卵巣奇形腫の診断までに時間を要した抗 NMDA 受容体脳炎の1例,
第15回四国神経懇話会, 2024年2月. 松本唯, 中瀧理仁, 石本良祐, 一宮俊文, 野田尚吾, 前田拓也, 増田太利志, 𠮷田朋広, 青井駿, 山田直輝, 富岡有紀子, 梅原英裕, 土師正太郎, 藤田浩司, 和泉唯信, 沼田周助 :
ADの灰白質体積と神経心理検査および髄液アミロイドβの関連性の検討,
【第42回日本認知症学会学術総会, 2023年11月. 松本唯, 中瀧理仁, 石本良祐, 一宮俊文, 野田尚吾, 前田拓也, 増田太利志, 𠮷田朋広, 青井駿, 山田直輝, 富岡有紀子, 梅原英裕, 土師正太郎, 藤田浩司, 和泉唯信, 沼田周助 :
認知症の灰白質体積と神経心理検査および髄液アミロイドβの関連性の検討,
第45回日本生物学的精神医学会年会, 2023年11月. 山上圭, 松原知康, 山﨑博輝, 藤田浩司, 原田雅史, 中道一生, 齋藤祐子, 村山繁雄, 和泉唯信 :
小脳・脳幹部優位のHIV関連進行性多巣性白質脳症を呈し呼吸不全で死亡した51歳男性例,
第27回日本神経感染症学会総会・学術大会, 2023年10月. 山上圭, 松原知康, 藤田浩司, 西田善彦, 齋藤祐子, 村山繁雄, 和泉唯信 :
行動異常を呈した高齢発症認知症の77歳男性の剖検例,
第64回日本神経病理学会総会学術研究会, 2023年7月. 和泉唯信, 松原知康, 織田雅也, 藤田浩司, 宮本亮介, 山上圭, 渡辺千種, 立山義朗, 齋藤祐子, 村山繁雄 :
Tokushima ALS Researchの臨床・病理実証研究,
第64回日本神経病理学会総会学術研究会, 2023年7月. M Yanagihashi, T Hirayama, M Shibukawa, J Nagasawa, Koji Fujita, Yuishin Izumi, M Morita, K Bokuda, K Takahashi, K Kanai, N Atsuta, Y Iguchi, M Katsuno, Y Murakami and O Kano :
The reliability of Japanese version Primary Lateral Sclerosis Functional Rating Scale (PLSFRS),
第64回日本神経学会学術大会, Jun. 2023. 前川恭平, 河野理, 松元友暉, 原田雅史, 藤田浩司 :
安静時fMRIを用いた前駆期パーキンソン病の新しい画像バイオマーカーの提案,
第25回日本ヒト脳機能マッピング学会, 2023年2月.

(キーワード): 安静時fMRI / 前駆期パーキンソン病 / 画像バイオマーカー

山上圭, 花田健太, 山本雄貴, 山﨑博輝, 大崎裕亮, 松井尚子, 藤田浩司, 和泉唯信 :
尿閉・便秘を呈したフィッシャー症候群の34歳男性例,
第112回日本神経学会中国・四国地方会, 2022年12月. 坂口暁, 佐藤康敬, 石田光代, 前田和輝, 二見明香里, 八木健太, 沖良祐, 藤田浩司, 楊河宏章, 和泉唯信, 梶龍兒, 石澤啓介 :
高用量メチルコバラミンの筋萎縮性側索硬化症に対する第III相試験の被験者及び家族におけるアンケート調査,
第43回日本臨床薬理学会学術総会, 2022年11月. 藤田浩司, Munkhzaya Chuluunbat, 松田大貴, 大友真姫, 音見暢一, 工藤與亮, 原田雅史, 和泉唯信 :
アルツハイマー病における灰白質ネットワーク,
第41回日本認知症学会学術集会, 2022年11月. 臼木貴子, 三島智美, 尾ぬか由美, 立花小枝, 遠藤静香, 湯浅美樹, 吉田まゆみ, 藤田浩司, 和泉唯信, 宮内吉男, 宇都宮正登 :
徳島市認知症初期集中支援チームの活動報告若年性認知症3事例の検討,
第22回日本早期認知症学会学術大会, 2022年9月. Munkhzaya Chuluunbat, Daiki Matsuda, Koji Fujita, Maki Ohtomo, Youichi Otomi, 工藤與亮, Masafumi Harada and Yuishin Izumi :
Alzheimer's disease-related gray matter volume network,
第22回日本早期認知症学会学術大会, Sep. 2022. 武藤浩平, 村上尚哉, 記本直輝, 藤田浩司, 和泉唯信 :
両側声帯麻痺により緊急気管切開を要したPR3-ANCA陽性肥厚性硬膜炎の1例,
第18回日本神経摂食嚥下・栄養学会学術集会東京大会, 2022年9月. 花田健太, 山本雄貴, 大崎裕亮, 島かさ音, 武藤浩平, 宮本亮介, 藤田浩司, 和泉唯信 :
Ocular flutterと体幹優位の運動失調を認めた抗NMDA受容体抗体陽性の若年女性例,
第111回日本神経学会中国・四国地方会, 2022年6月. 武藤浩平, 村上尚哉, 記本直輝, 藤田浩司, 和泉唯信 :
両側声帯麻痺により緊急気管切開を要したPR3-ANCA陽性肥厚性硬膜炎の1例,
第111回日本神経学会中国・四国地方会, 2022年6月. 花田健太, 山本雄貴, 大崎裕亮, 島かさ音, 武藤浩平, 宮本亮介, 藤田浩司, 和泉唯信 :
Ocular flutterと体幹優位の運動失調を認めた抗NMDA受容体抗体陽性の若年女性例,
第63回日本神経学会学術大会, 2022年5月. 武藤浩平, 村上尚哉, 記本直輝, 藤田浩司, 和泉唯信 :
両側声帯麻痺により緊急気管切開を要したPR3-ANCA陽性肥厚性硬膜炎の1例,
第63回日本神経学会学術大会, 2022年5月. 福島功士, 高松直子, 山本雄貴, 山﨑博輝, 吉田剛, 土師正太郎, 大崎裕亮, 藤田浩司, 杉江和馬, 和泉唯信 :
筋超音波検査の線維束性収縮に基づく筋萎縮性側索硬化症の診断マーカー,
第63回日本神経学会学術大会, 2022年5月. 山本雄貴, 山本伸昭, 兼松康久, 黒田一駿, 藤田浩司, 髙木康志, 和泉唯信 :
徳島市におけるアプリケーションを用いた病院前脳主幹動脈閉塞診断スケールの活用,
第63回日本神経学会学術大会, 2022年5月. 土師正太郎, 藤田浩司, 沖良祐, 大崎裕亮, 金澤裕樹, 松元友暉, 有澤亜津子, 川井恒, 佐藤康敬, 八木健太, 坂口暁, 楊河宏章, 濱谷辰斗, 長野清一, 望月秀樹, 熱田直樹, 道勇学, 祖父江元, 原田雅史, 和泉唯信 :
EPI-589の筋萎縮性側索硬化症を対象とした探索的医師主導試験(EPIC-ALS),
第63回日本神経学会学術大会, 2022年5月. 前川恭平, 河野理, 松元友暉, 原田雅史, 藤田浩司 :
Voxel-to-Voxelコネクトーム解析を用いたパーキンソン病の安静時fMRI,
第24回日本ヒト脳機能マッピング学会, 2022年2月. 森垣龍馬, 藤川丈自, 松田拓, 三宅一央, 牟礼英生, 小田輝王, 宮本亮介, 藤田浩司, 山本伸昭, 和泉唯心, 髙木康志 :
特発性ジストニア患者の頭蓋骨の歪み,
日本定位・機能神経外科学会機関紙, 2022年1月. 松原知康, 和泉唯信, 土師正太郎, 山﨑博輝, 大崎裕亮, 宮本亮介, 藤田浩司, 齋藤祐子, 村山繁雄 :
Lewy小体型認知症と筋萎縮性側索硬化症を合併した1例,
第62回日本神経病理学会総会学術研究会, 2021年5月. 沖良祐, 和泉唯信, 藤田浩司, 佐藤康敬, 二見明香理, 前田和輝, 八木健太, 坂口暁, 楊河宏章, 桑原聡, 梶龍兒 :
COVID-19流行下におけるALSを対象とした医師主導治験運営の取組み,
第62回日本神経学会学術大会, 2021年5月. 藤田浩司, 和泉唯信 :
ALSにおける心血管系および自律神経系異常,
第62回日本神経学会学術大会シンポジウム24, 2021年5月. 島かさ音, 藤田浩司, 大崎裕亮, 和泉唯信 :
中枢神経ゴム腫で発症した梅毒の 1 例,
第124回日本内科学会四国地方会, 2021年5月. 河野理, 佐藤大亮, 隅田奈美, 松元友暉, 原田雅史, 藤田浩司 :
Voxel-to-voxel コネクトーム解析を用いたジストニアの安静時fMRI,
第23回日本ヒト脳機能マッピング学会(WEB開催), 2021年3月. 森垣龍馬, 牟礼英生, 松田拓, 三宅一央, 宮本亮介, 藤田浩司, 中瀧理仁, 梶龍兒, 髙木康志, 後藤惠 :
機能ー器質ボーダーラインジストニアに対する脳深部刺激療法,
第60回日本定位・機能神経外科学会, 2021年1月. 牟礼英生, 森垣龍馬, 小山広士, 三宅一央, 松田拓, 宮本亮介, 藤田浩司, 和泉唯信, 後藤惠, 髙木康志 :
遅発性ジストニアに対する淡蒼球内節刺激術12例の検討ー適応・長期成績・刺激条件についてー,
第60回日本定位・機能神経外科学会, 2021年1月. 武藤浩平, 宮本亮介, 寺澤由佳, 藤田浩司, 和泉唯信 :
てんかん発作と繰り返す鼻出血を認めた新規COL4A1変異の1例,
第108回日本神経学会中国・四国地方会, 2020年12月. 高原実香, 山本伸昭, 宮本亮介, 藤田浩司, 和泉唯信, 住谷龍平, 中村信元, 安倍正博, 島津秀紀, 西田善彦 :
意識障害，高アンモニア血症を呈した78歳男性,
四国医学雑誌, Vol.76, No.5-6, 346, 2020年12月.

(キーワード): Dexamethasone(治療的利用) / 意識障害(病因) / 腫瘍多剤併用療法 / 骨髄腫-多発性(合併症,病理学,薬物療法) / 高アンモニア血症(病因,診断) / Bortezomib(治療的利用) / BD Protocol (Bortezomib-Dexamethasone) / ヒト / 高齢者(65~79) / 男

藤田浩司, 原田雅史, 岩崎靖, 赤木明生, 島かさ音, 谷口浩一郎, 吉田眞理, 和泉唯信 :
クロイツフェルト・ヤコブ病の拡散尖度画像,
第39回日本認知症学会学術集会, 2020年11月. 牟礼英生, 森垣龍馬, 小山広士, 大北真哉, 松田拓, 佐光亘, 宮本亮介, 藤田浩司, 和泉唯信, 梶龍兒, 後藤惠, 髙木康志 :
遅発性ジストニアに対する淡蒼球内節刺激術12例の検討:適応・長期成績・刺激条件について,
第79回日本脳神経外科学会総会, 2020年10月. 福本竜也, 宮本亮介, 藤田浩司, 松井尚子, 和泉唯信 :
抗AMPA受容体抗体による傍腫瘍性神経症候群の76歳男性例,
第32回日本神経免疫学会学術集会, 2020年10月. 隅田奈美, 原田雅史, 河野理, 松元友暉, 金澤裕樹, Gonchigsuren Oyundari, 藤田浩司 :
運動異常症の安静時 fMRIにおける脳機能ネットワークの検討,
第48回日本磁気共鳴医学会大会Web開催, 2020年9月. 高原実香, 福本竜也, 垂髪祐樹, 山本伸昭, 宮本亮介, 藤田浩司, 和泉唯信 :
長い精神病期と，広範な大脳白質病変を呈した抗NMDA受容体脳炎の35歳男性,
第61回日本神経学会学術大会, 2020年8月. 牟礼英生, 藤田浩司, 森垣龍馬, 宮本亮介, 松田拓, 後藤惠, 髙木康志, 後藤惠 :
FDG PETを用いたジストニア患者の脳代謝ネットワークパターンの描出,
機能的脳神経外科, 132, 2020年1月. 宮本亮介, 藤田浩司, 牟礼英生, 森垣龍馬, 中瀧理仁, 和泉唯信, 後藤惠, 梶龍兒 :
ヒステリー性麻痺の臨床診断と電気生理心因性運動障害の診断心因性ジストニアを中心に,
第49回日本臨床神経生理学会学術大会, 2019年11月. 山本雄貴, 山本伸昭, 福本竜也, 村上永久, 宮本亮介, 藤田浩司, 牟礼英生, 兼松康久, 髙木康志, 和泉唯信 :
転倒を契機に脳脊髄液減少症と静脈洞血栓症を合併し，ブラッドパッチにて治療した脊髄小脳変性症6型の1例,
第37回日本神経治療学会学術集会, 2019年11月. 牟礼英生, 藤田浩司, 森垣龍馬, 宮本亮介, 後藤惠, 髙木康志 :
FDG PETを用いたジストニア患者の脳代謝ネットワークパターンの描出,
日本脳神経外科学会第78回学術集会, 2019年10月. 福本竜也, 宮本亮介, 山﨑博輝, 村上永尚, 大崎裕亮, 藤田浩司, 野寺裕之, 瓦井俊孝, 和泉唯信, 梶龍兒 :
特異な歩行障害を呈したGerstmann-Straussler-Scheinker病の31歳男性,
第105回日本神経学会中国・四国地方会, 2018年12月. 鎌田正紀, 中根俊成, 松井尚子, 樋口理, 酒井和香, 藤田浩司, 和泉唯信, 松尾秀徳, 梶龍兒 :
抗MuSK抗体陽性の眼筋型重症筋無力症,
第28回日本神経免疫学会学術集会, 172, 2016年9月. 松井尚子, 宮﨑由道, 大崎裕亮, 宮城愛, 森敦子, 丸山恵子, 島谷佳光, 藤田浩司, 野寺裕之, 梶龍兒 :
ギラン・バレー症候群に対するIVIg前後の血清IgG値の変動と治療効果,
第26回日本神経免疫学会学術集会, 2015年9月. 和泉唯信, 隅蔵大幸, 宇髙不可思, 武内俊明, 藤田浩司, 野寺裕之, 瓦井俊孝, 村山繁雄, 梶龍兒 :
進行性核上性麻痺が先行した筋萎縮性側索硬化症2例の臨床病理学的検討,
第56回日本神経学会学術大会, 2015年5月. 古川貴大, 松井尚子, 宮城愛, 野寺裕之, 藤田浩司, 清水文祟, 宮本勝一, 高橋幸利, 神田隆, 楠進, 梶龍兒 :
MMNのサイトカイン・ケモカインプロファイル,
第56日本神経学会学術大会, 2015年5月. 竹内俊明, 宮本亮介, 大崎裕亮, 山本伸昭, 藤田浩司, 松井尚子, 和泉唯信, 梶龍兒 :
弛緩性麻痺と不随意運動を呈した日本脳炎の一例,
第111回日本内科学会四国地方会, 2014年11月. 沖良祐, 藤田浩司, 松井尚子, 村上永尚, 宮本亮介, 宮﨑由道, 和泉唯信, 梶龍兒 :
高齢発症破傷風例の治療経験を通じた本邦破傷風診療に関する提言,
第19回日本神経感染症学会総会, 2014年9月. 大崎裕亮, 松井尚子, 葛目大輔, 藤田浩司, 野寺裕之, 尾本雅俊, 海田賢一, 和泉唯信, 神田隆, 梶龍兒 :
抗Neurofascin抗体陽性Lewis-Sumner症候群の1例,
第96回日本神経学会中国・四国地方会, 2014年6月. 橋口修二, 足立克仁, 川村和之, 有井敬治, 三ツ井貴夫, 乾俊夫, 岡田稔子, 香川典子, 藤田浩司, 梶龍兒 :
Creutzfeldt-Jacob病の剖検例の検討 -大脳皮質のMRI拡散強調画像と病理所見ー,
第55回日本神経学会学術大会, 2014年5月. 山本伸昭, 寺澤由佳, 藤田浩司, 和泉唯信, 梶龍兒, 森垣龍馬, 多田恵曜, 里見淳一郎, 永廣信治 :
急性期虚血性脳卒中患者のT2*強調画像所見とその変化,
2014年脳卒中学会総会, 2014年3月. 山本伸昭, 寺澤由佳, 藤田浩司, 和泉唯信, 梶龍兒, 森垣龍馬, 多田恵曜, 里見淳一郎, 永廣信治 :
急性期虚血性脳卒中患者のT2*強調画像所見とその変化,
第39回日本脳卒中学会総会, 2014年3月. 山本伸昭, 寺澤由佳, 藤田浩司, 和泉唯信, 梶龍兒, 森垣龍馬, 里見淳一郎, 永廣信治, 原田雅史 :
主幹動脈閉塞に伴う虚血性脳卒中における3T-MR T2*-weighted image所見とその変化,
第16回徳島脳卒中研究会, 2014年2月. 宮﨑由道, 宮本亮介, 宮城愛, 藤田浩司, 和泉唯信, 梶龍兒 :
塩酸ドネペジルにて歩行障害の改善を見たiNPHの一例,
パーキンソン病・運動障害疾患コングレスプログラム・抄録集, 105, 2014年.

(キーワード): *水頭症-正常圧(合併症,診断,薬物療法) *歩行障害-神経性(病因,診断,薬物療法) *Donepezil(治療的利用) *すくみ足歩行(病因,診断,薬物療法) ヒト高齢者(65~79) 男

宮﨑由道, 松井尚子, 藤田浩司, 大崎裕亮, 森敦子, 丸山恵子, 島谷佳光, 野寺裕之, 梶龍兒 :
ギラン・バレー症候群に対するIVIg前後の血清IgG値の変動と治療効果,
臨床神経学, Vol.54, No.Suppl., S107, 2014年. 宮﨑由道, 鎌田正紀, 藤田浩司, 松井尚子, 和泉唯信, 村山繁雄, 梶龍兒 :
急激な経過をたどったLymphomatosis cerebriの1例,
第109回日本内科学会四国地方会, 2013年12月. 藤田浩司, 湯浅龍彦, 高橋幸利, 田中恵子, 岩崎靖, 松井尚子, 和泉唯信, 梶龍兒 :
抗NMDA受容体抗体陽性のCreutzfeldt-Jakob病と免疫関連脳炎の鑑別,
第25回日本神経免疫学会学術集会, 2013年11月. 松井尚子, 古川貴大, 藤田浩司, 宮﨑由道, 佐藤健太, 和泉唯信, 西田善彦, 梶龍兒 :
Fingolimodはrecent thymic emigrantへの影響,
第25回日本神経免疫学会学術集会, 2013年11月. 橋口修二, 川村和之, 有井敬治, 三ツ井貴夫, 足立克仁, 藤田浩司, 梶龍兒, 香川典子 :
緩徐進行性の孤発性クロイツフェルト・ヤコブ病(MM1+2型)の79歳剖検例,
第108回日本内科学会四国地方会, 2013年6月. J Hotchi, 八木秀介, 岩瀬俊, 山田博胤, 佐田政隆, 近藤剛史, 福森知治, 藤田浩司, 寺澤由佳, 井上昌幸, H Sato :
原発性副甲状腺機能亢進症・高血圧・糖尿病・脂質異常症に合併した若年性多発性脳梗塞の一例,
第246回徳島医学会学術集会(平成24年度冬期), 2013年2月. 宮﨑由道, 佐藤健太, 藤田浩司, 和泉唯信, 梶龍兒 :
早期PD患者のMIBG心筋シンチとwearing-off発症の関連,
臨床神経学, Vol.53, No.12, 1613, 2013年.

(キーワード): *Parkinson病(放射性核種診断) *薬物反応性低下 *Iobenguane(診断的利用) *心筋血流イメージング *Wearing-off現象ヒト

Toshitaka Kawarai, Mitsuya Morita, Ryoma Morigaki, Koji Fujita, Hiroyuki Nodera, Yuishin Izumi, Satoshi Goto, Imaharu Nakano and Ryuji Kaji :
Pathomechanisms of motor neuron death by mutant TFG.,
Clinical Neurology, Vol.23, No.11, 1199, 2013.

(要約): Mutations in TFG gene have been demonstrated in hereditary motor and sensory neuropathy with proximal dominant involvement (HMSN-P) and hereditary spastic paraplegia (HSP). A broad spectrum of TFG pathology is suspected in motor neuron diseases including amyotrophic lateral sclerosis (ALS). We performed mutation screening of TFG gene in ALS cases and evaluated the biological functions of mutant TFG by expression experiment in cultured cells. Two missense mutations associated with sporadic ALS were discovered. Mislocalization of ALS-related proteins, including TDP-43 and optineurin, was demonstrated. These results indicate that mistrafficking of ALS-related proteins by mutant TFG might be a biological cascade leading to motor neuron death.
(キーワード): Humans / Mutation, Missense / Proteins / Spastic Paraplegia, Hereditary
(出版サイトへのリンク): ● Publication site (DOI): 10.5692/clinicalneurol.53.1199
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24291928; ● Summary page in Scopus @ Elsevier: 2-s2.0-84891811182

(DOI: 10.5692/clinicalneurol.53.1199, PubMed: 24291928, Elsevier: Scopus) 香川耕造, 河野弘, 藤田浩司, 村上永尚, 岸潤, 埴淵昌毅, 梶龍兒, 西岡安彦 :
MPO-ANCA関連肥厚性硬膜炎の1例,
第107回日本内科学会四国地方会, 2012年12月. 古川貴大, 藤田浩司, 和泉唯信, 清水文崇, 宮本勝一, 高橋幸利, 神田隆, 楠進, 梶龍兒 :
MMNおよびALSにおけるサイトカイン・プロファイル,
第24回日本神経免疫学会学術集会, 2012年9月. 酒井和香, 松井尚子, 寺澤由佳, 藤田浩司, 佐藤健太, 鎌田正紀, 和泉唯信, 梶龍兒 :
50歳以上発症重症筋無力症における臨床像 64歳迄vs65歳以上,
第53回日本神経学会学術大会, 2012年5月. 矢野祖, 近藤真代, 河野弘, 西條敦郎, 豊田優子, 柿内聡司, 岸潤, 埴淵昌毅, 西岡安彦, 古川貴大, 藤田浩司 :
神経サルコイドーシスの1例,
第244回徳島医学会学術集会, 2012年2月. 森剛志, 村松直美, 犬伏祥子, 山口仁孝, 矢野雅司, 藤田浩司, 坂口末廣 :
プリオン蛋白過剰発現誘導性細胞死の分子機構,
第33回日本分子生物学会年会,第83回日本生化学会大会合同大会, 2010年12月. 森剛志, 村松直美, 犬伏祥子, 山口仁孝, 矢野雅司, 藤田浩司, 坂口末廣 :
プリオン蛋白過剰発現誘導性細胞死の分子機構,
第33回日本分子生物学会年会,第83回日本生化学会大会合同大会プリオン蛋白過剰発現誘導性細胞死の分子機構神戸ポートアイランド, 2010年12月. 村松直美, 森剛志, 山口仁孝, 藤田浩司, 坂口末廣 :
A prion protein with familial mutation, PrP-Y145Stop, induces cell death through G2 cell cycle arrest,
第33回日本分子生物学会年会,第83回日本生化学会大会合同大会神戸ポートアイランド, 2010年12月. 島谷佳光, 松井尚子, 宮城愛, 浅沼光太郎, 藤田浩司, 寺澤由佳, 佐藤健太, 和泉唯信, 梶龍兒 :
Neuromyelitis opticaにおけるVEPの検討,
臨床神経生理学, Vol.38, No.5, 330, 2010年10月.

(キーワード): *視神経脊髄炎; *視覚誘発電位 / ヒト (Homo sapiens)

山本伸昭, 寺澤由佳, 藤田浩司, 森垣龍馬, 里見淳一郎, 梶龍兒, 永廣信治 :
3T MRI T2強調画像におけるischemic vessel signsの検討,
第39回日本脳卒中の外科学会, 2010年4月. 宮﨑由道, 山本伸昭, 藤田浩司, 中村和己, 和泉唯信, 梶龍兒 :
脳小血管病変(SVD)はパーキンソン症状を悪化させる,
臨床神経学, Vol.50, No.12, 1248, 2010年.

(キーワード): 血管疾患病勢悪化 *パーキンソニズム(合併症) *脳小血管病(合併症) ヒト

藤田浩司, 阿部秀一, 和泉唯信, 山田博胤, 森田直美, 原田雅史, 永廣信治, 梶龍兒 :
心筋障害・心房中隔瘤に伴い心原性脳塞栓症を呈したBecker型筋ジストロフィーの1例,
第9回徳島臨床脈管研究会, 2007年9月.

研究会・報告書: 多田里穂, 武藤浩平, 松井尚子, 藤田浩司, 和泉唯信 :
散在性の脳実質病変を認め自己免疫性脳炎を疑った一例,
第114回日本神経学会中国・四国地方会, 2023年12月. 土師正太郎, 藤田浩司, 長野清一, 熱田直樹, 望月秀樹, 祖父江元 :
EPI-589の筋萎縮性側索硬化症を対象とした探索的試験 - ALS医師主導治験 - (EPIC-ALS) の進捗状況,
神経変性班会議, 2022年12月. 山本伸昭, 藤田浩司, 和泉唯信, 梶龍兒, 山口泉, 里見淳一郎, 永廣信治, 山田博胤, 木下肇, 北川哲也 :
心内巨大血栓に伴う急性期脳梗塞の1例,
第16回徳島脳血管障害カンファレンス, 2014年4月. 梶龍兒, 宮﨑由道, 松井尚子, 藤田浩司, 大崎裕亮, 森敦子, 丸山恵子, 島谷佳光, 野寺裕之 :
ギラン・バレー症候群に対するIVIg前後の血清IgG値の変動と治療効果,
免疫性神経疾患に関する調査研究班(平成25年度), 2014年1月. Sakai Waka, Naoko Matsui, Koji Fujita and Ryuji Kaji :
A case of NMO spectrum disorder associated with SIADH,
Sendai Conference 2012, Jul. 2012. 森剛志, 村松直美, 山口仁孝, 犬伏祥子, 矢野雅司, 藤田浩司, 坂口末廣 :
プリオン蛋白過剰発現により誘導される細胞死の機序,
第26回中国四国ウイルス研究会岡山大学創立50周年記念館岡山, 2010年6月. 梶龍兒, 宮﨑由道, 松井尚子, 藤田浩司, 大崎裕亮, 森敦子, 丸山恵子, 島谷佳光, 野寺裕之 :
ギラン・バレー症候群に対するIVIg前後の血清IgG値の変動と治療効果,
免疫性神経疾患に関する調査研究班(平成25年度), 154-155, 東京, 2014年.

特許: 研究者総覧に該当データはありませんでした。
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補助金・競争的資金: パーキンソン病関連疾患における機能的脳ネットワークマーカーの開発 (研究課題/領域番号: 24K15767 )
ジストニアの安静時機能的ネットワークの解明および白質微細構造情報の統合 (研究課題/領域番号: 20K07868 )
ジストニアの白質微細構造ネットワーク (研究課題/領域番号: 19K21302 )
プリオン病においてNMDA型グルタミン酸受容体抗体が病態に果たす役割の解明 (研究課題/領域番号: 25860715 )
研究者番号（80601765）による検索

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2024年11月15日更新

専門分野・研究分野: ライフサイエンス (Life sciences) [神経科学一般 (Neuroscience - general)]
ライフサイエンス (Life sciences) [神経内科学 (Neurology)]
所属学会・所属協会: 日本神経学会
日本神経病理学会
委員歴・役員歴: 日本神経学会 (ALS診療ガイドライン作成委員会委員 [2020年9月〜2025年1月])
日本神経病理学会 (広報委員会委員 [2022年4月〜2023年3月])
受賞: 2023年2月, 康楽賞 (公益財団法人康楽会)
2023年3月, 令和4年度大学院医歯薬学研究部長表彰 (大学院医歯薬学研究部)
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Jグローバル最終確認日: 2024/11/9 01:28
氏名（漢字）: 藤田浩司
氏名（フリガナ）: フジタコウジ
氏名（英字）: Fujita Koji
所属機関: 徳島大学大学院医歯薬学研究部講師

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researchmap最終確認日: 2024/11/10 01:55
氏名（漢字）: 藤田浩司
氏名（フリガナ）: フジタコウジ
氏名（英字）: Fujita Koji
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登録日時: 2018/11/1 17:44
更新日時: 2024/10/20 21:29
アバター画像URI: https://researchmap.jp/fujita_koji/avatar.JPG
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所属ID: 0344000000
所属: 徳島大学大学院医歯薬学研究部
部署: 臨床神経科学分野
職名: 講師
学位: 学士（医学）
学位授与機関: 徳島大学
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2024年11月9日更新

研究者番号: 80601765

所属（現在）: 2024/4/1 : 徳島大学, 大学院医歯薬学研究部(医学域), 講師

所属（過去の研究課題 情報に基づく）*注記: 2024/4/1 : 徳島大学, 大学院医歯薬学研究部(医学域), 講師
2021/4/1 – 2022/4/1 : 徳島大学, 大学院医歯薬学研究部(医学域), 講師
2020/4/1 : 徳島大学, 病院, 特任講師
2018/4/1 – 2019/4/1 : 徳島大学, 病院, 特任助教
2013/4/1 – 2014/4/1 : 徳島大学, ヘルスバイオサイエンス研究部, 助教

審査区分/研究分野: 研究代表者

生物系 / 医歯薬学 / 内科系臨床医学 / 神経内科学
0902:内科学一般およびその関連分野
小区分52020:神経内科学関連
小区分90130:医用システム関連

キーワード: 研究代表者

プリオン病 / 抗体 / グルタミン酸受容体 / ジストニア / 磁気共鳴画像 / 拡散テンソル画像 / ネットワーク / 大脳白質 / 主成分分析 / MRI / fMRI / 安静時機能的磁気共鳴画像 / パーキンソン病 / 進行性核上性麻痺 / 多系統萎縮症 / バイオマーカー

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2021年3月25日

人工知能技術に基づく個々の病態に最適化された治療的介入技法（AI-Based Behavior Modification: AiBM）の創出

山本哲也大森哲郎中瀧理仁内海千種牟礼英生森垣龍馬藤田浩司宮本亮介

2021年12月24日

【医師主導治験】筋萎縮性側索硬化症（ALS）を対象とした新規薬剤の治験の開始について

和泉唯信藤田浩司

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藤田 浩司

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