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中本真理子

徳島大学

プロフィール
教育活動
研究活動
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リサーチマップ・
Jグローバル
KAKEN
注目研究

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2024年5月2日更新

職名: 講師
電話: 研究者総覧に該当データはありませんでした。
電子メール: nakamoto@tokushima-u.ac.jp
学歴: 2004/4: 徳島大学医学部栄養学科 ( - 2008. 3.)
2008/4: 徳島大学大学院栄養生命科学教育部博士前期課程 ( - 2010. 3.)
2010/4: 徳島大学大学院栄養生命科学教育部博士後期課程 ( - 2013. 3.)
学位: 博士(栄養学) (徳島大学) (2013年)
職歴・経歴: 2013/4: 日本学術振興会特別研究員(PD)
2014/4: 国立長寿医療研究センター老年学・社会科学研究センター NILS-LSA活用研究室
2015/4: 徳島大学大学院医歯薬学研究部

専門分野・研究分野: 公衆栄養学 (Public Health Nutrition)
公衆衛生学 (Public Health)
栄養疫学

研究者総覧で最新データを確認する

2024年5月2日更新

専門分野・研究分野: 公衆栄養学 (Public Health Nutrition)
公衆衛生学 (Public Health)
栄養疫学
担当経験のある授業科目: オリエンテーション(4年生) (学部)
データ解析学 (学部)
公衆栄養学 (学部)
公衆栄養学実習 (学部)
公衆衛生学実習 (学部)
地域公衆栄養学 (学部)
実践栄養学演習 (学部)
栄養英語 (学部)
給食栄養管理論 (学部)
給食栄養管理論実習 (学部)
給食運営管理論 (学部)
給食運営管理論実習 (学部)
指導経験: 研究者総覧に該当データはありませんでした。

研究者総覧で最新データを確認する

2024年5月2日更新

専門分野・研究分野: 公衆栄養学 (Public Health Nutrition)
公衆衛生学 (Public Health)
栄養疫学

研究テーマ: 徳島県における職域コホート研究, 老化に関する長期縦断疫学研究(NILS-LSA), 大豆製品・大豆含有成分と健康, 子育て世代のワークライフバランスと食生活, 子供の存在がその親の食習慣に与える影響の研究(POTATO Study)

著書

酒井徹, 郡俊之, 中本真理子, 中本晶子 :
公衆栄養学第7版,
株式会社講談社, 東京, 2023年1月. 中本真理子 :
管理栄養士養成のための栄養学教育モデル・コア・カリキュラム準拠第10巻「公衆栄養学」2021年版,
2021年3月. 中本真理子 :
公衆栄養学第5版,
株式会社講談社サイエンティフィク, 東京, 2015年2月. 中本真理子 :
臨床栄養実践ガイド(免疫疾患(食物アレルギーなど)),
株式会社中外医学社, 東京, 2014年8月.

論文

TANAKA Yuko, YAMAMOTO Mako, Haruka Ohhashi, Akiko Nakamoto, Mariko Nakamoto and Tohru Sakai :
The Soy Isoflavone Genistein Enhances IFN-γ-Induced PD-L1 Expression in B16F1 Melanoma Cells in Vitro,
BPB Reports, Vol.7, No.1, 21-25, 2024. Mako Yamamoto, Yuko Tanaka, Risako Takeda, Akiko Nakamoto, Mariko Nakamoto, Hideo Yagita and Tohru Sakai :
Soy isoflavone genistein attenuates the efficacy of immune checkpoint therapy in C57BL/6 mice inoculated with B16F1 melanoma and a high PD-L1 expression level reflects tumor resistance.,
Journal of Clinical Biochemistry and Nutrition, Vol.74, No.1, 57-62, 2023.

(要約): cells and the concentrations of interferon-γ and tumor necrosis factor-α in tumor tissue were not different among the experimental groups. A significant difference was also not found in microbe composition. Interestingly, a high expression level of PD-ligand (L)1 closely reflected the outcome of therapy by genistein or anti-PD-1 antibody. The study showed that a combination of genistein treatment does not improve the effect of immune blockade therapy. It also showed that a high PD-L1 expression level in tumors is a good prediction maker for the outcome of tumor therapy.
(出版サイトへのリンク): ● Publication site (DOI): 10.3164/jcbn.23-76
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38292119; ● Search Scopus @ Elsevier (PMID): 38292119; ● Search Scopus @ Elsevier (DOI): 10.3164/jcbn.23-76

(DOI: 10.3164/jcbn.23-76, PubMed: 38292119) Akiko Nakamoto, Yuwa Hirabayashi, Chieri Anzaki, Mariko Nakamoto, Emi Shuto, Yoshitaka Nii and Tohru Sakai :
Effects of polymethoxyflavonoids on T helper 17 cell differentiation in vitro and in vivo.,
The Journal of Medical Investigation : JMI, Vol.70, No.1.2, 166-170, 2023.

(徳島大学機関リポジトリ): ● Metadata: 118348
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.70.166
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37164715; ● Search Scopus @ Elsevier (PMID): 37164715; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.70.166

(徳島大学機関リポジトリ: 118348, DOI: 10.2152/jmi.70.166, PubMed: 37164715) Mariko Nakamoto, Nagashima Tsuzuri, Tanaka Yukiko, Ono Satomi, Iwasaki Yuki, Nakamoto Akiko, Zhang Shu, Kinoshita Kaori, Furuya Kanae, Imai Tomoko, Otsuka Rei and Tohru Sakai :
Validation of a dietary balance score in middle-aged and older community-dwelling Japanese,
The Journal of Medical Investigation : JMI, Vol.70, No.3.4, 377-387, 2023.

(キーワード): dietary balance / middle-aged and older community-dwelling Japanese / nutritional balance

Akiko Nakamoto, Miho Goto, Hina Hasegawa, Chieri Anzaki, Mariko Nakamoto, Emi Shuto and Tohru Sakai :
Essential Oil of Citrus sudachi Suppresses T Cell Activation Both In Vitro and In Vivo.,
Journal of Nutritional Science and Vitaminology, Vol.68, No.6, 513-520, 2022.

(出版サイトへのリンク): ● Publication site (DOI): 10.3177/jnsv.68.513
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36596549; ● Search Scopus @ Elsevier (PMID): 36596549; ● Search Scopus @ Elsevier (DOI): 10.3177/jnsv.68.513

(DOI: 10.3177/jnsv.68.513, PubMed: 36596549) Mariko Nakamoto, Miku Kanmura, Mai Yoshida, Yukiko Tanaka, Satomi Ono, Yuki Iwasaki, Akiko Nakamoto and Tohru Sakai :
Validity of dietary diversity assessed using short-form questionnaire among older Japanese community dwellers.,
The Journal of Medical Investigation : JMI, Vol.69, No.1.2, 31-37, 2022.

(要約): The validity of dietary variety score (DVS) using a short-form questionnaire has not been investigated using dietary diversity based on a quantitative distribution of consumed foods in older Japanese. We examined the association between DVS and objective dietary diversity using a Quantitative Index for Dietary Diversity (QUANTIDD) based on the quantitative distribution of foods consumed by older Japanese community dwellers. The subjects were 65 older Japanese community dwellers aged 60?79 years. We used two kinds of scores for assessment of dietary diversity. At first, dietary diversity was determined using DVS calculated from answers to a questionnaire about frequencies of intake of 10 food groups. Second, dietary intake was assessed using a 3-day dietary record with photographs, and dietary diversity was determined using QUANTIDD. The relationships between DVS and QUANTIDD were assessed using partial correlation coefficients controlling for confounders. The correlation coefficient between DVS and QUANTIDD was moderate (r=0.212-0.458). After controlling for confounders, those correlation coefficient between DVS and QUANTIDD remained moderate. The findings suggest that there was a moderate relationship between DVS and QUANTIDD, and DVS using a short-form questionnaire may be useful for assessing dietary diversity in older Japanese community dwellers. J. Med. Invest. 69 : 31-37, February, 2022.
(キーワード): Aged / Diet / Eating / Food / Humans / Japan / Surveys and Questionnaires
(徳島大学機関リポジトリ): ● Metadata: 117008
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.69.31
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35466143; ● Search Scopus @ Elsevier (PMID): 35466143; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.69.31

(徳島大学機関リポジトリ: 117008, DOI: 10.2152/jmi.69.31, PubMed: 35466143) Mariko Nakamoto, Miku Kanmura, Mai Yoshida, Kana Yamada, Akiko Nakamoto and Tohru Sakai :
Dietary diversity and food choice motives during the COVID-19 pandemic among older Japanese: An Internet Panel Survey.,
Asia Pacific Journal of Clinical Nutrition, Vol.31, No.3, 433-440, 2022.

(要約): The findings suggest that the COVID-19 pandemic was associated with an increase in some food choice motives and a decrease in the frequency of eating out among elderly female Japanese.
(キーワード): Aged / COVID-19 / Diet / Feeding Behavior / Female / Humans / Internet / Japan / Male / Pandemics / Retrospective Studies / Surveys and Questionnaires
(出版サイトへのリンク): ● Publication site (DOI): 10.6133/apjcn.202209_31(3).0011
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36173215; ● Search Scopus @ Elsevier (PMID): 36173215; ● Search Scopus @ Elsevier (DOI): 10.6133/apjcn.202209_31(3).0011

(DOI: 10.6133/apjcn.202209_31(3).0011, PubMed: 36173215) Akiko Nakamoto, Hirabayashi Yuwa, Anzaki Chieri, Mariko Nakamoto, Emi Shuto and Tohru Sakai :
Nobiletin suppresses the development of experimental autoimmune encephalomyelitis mediated by modulation of T helper 17 cell differentiation,
Journal of Clinical Biochemistry and Nutrition, Vol.69, No.2, 145-150, 2021.

(要約): Multiple sclerosis is an organ-specific autoimmune disease that targets the myelin antigen in the central nervous system. Nobiletin is a dietary polymethoxylated flavonoid found in citrus fruits. In this study, we investigated how nobiletin affects the disease state and immune responses to myelin oligodendrocyte glycoprotein in experimental autoimmune encephalomyelitis mice. Nobiletin was administered orally from 14 days before immunization until the end of the experiment, and clinical scores were determined. The production levels of interleukin-17A and interferon-γ were measured in a culture supernatant of splenocytes stimulated with myelin oligodendrocyte glycoprotein. In addition, flow cytometric analysis was performed to examine the effect of nobiletin on T cell differentiation . Admin-istration of nobiletin significantly decreased the clinical score and interleukin-17A production in splenocytes. Furthermore, analysis showed that nobiletin significantly suppressed Th17 cell differentiation and interleukin-17A production in a dose-dependent manner. The results suggest that nobiletin attenuates experimental autoimmune encephalomyelitis severity through modulation of Th17 cell differentiation.
(徳島大学機関リポジトリ): ● Metadata: 116141
(出版サイトへのリンク): ● Publication site (DOI): 10.3164/JCBN.20-178
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34616106; ● Summary page in Scopus @ Elsevier: 2-s2.0-85114706108

(徳島大学機関リポジトリ: 116141, DOI: 10.3164/JCBN.20-178, PubMed: 34616106, Elsevier: Scopus) Mariko Nakamoto, Rei Otsuka, Chikako Tange, Yukiko Nishita, Makiko Tomida, Tomoko Imai, Tohru Sakai, Fujiko Ando and Hiroshi Shimokata :
Intake of isoflavones reduces the risk of all-cause mortality in middle-aged Japanese.,
European Journal of Clinical Nutrition, 2021.

(要約): There were 491 deaths during the follow-up period. We found inverse associations of the intake of total soy products and intake of each of the isoflavones with all-cause mortality (p for trend < 0.05) in subjects aged < 60 years: the multivariate-adjusted hazard ratios (95% confidence intervals) for all-cause mortality in the highest intake group (third tertile) of total soy products and total isoflavones were 0.32 (0.13-0.78) and 0.35 (0.17-0.73), respectively, compared with the reference group (first tertile). In contrast, there were no significant associations of intake amounts of legumes, soybeans, and isoflavones with all-cause mortality in subjects aged 60 years or older.
(出版サイトへのリンク): ● Publication site (DOI): 10.1038/s41430-021-00890-w
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33712722; ● Search Scopus @ Elsevier (PMID): 33712722; ● Search Scopus @ Elsevier (DOI): 10.1038/s41430-021-00890-w

(DOI: 10.1038/s41430-021-00890-w, PubMed: 33712722) Akiko Nakamoto, Risako Takeda, Yuwa Hirabayashi, Mariko Nakamoto, Emi Shuto and Tohru Sakai :
Citrus Polymethoxyflavonoids, Nobiletin, Heptamethoxyflavone and Natsudaidain, Suppress T Cell Activation In Vitro and In Vivo,
BPB Reports, Vol.3, No.4, 138-141, 2020.

(出版サイトへのリンク): ● Publication site (DOI): 10.1248/bpbreports.3.4_138
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1248/bpbreports.3.4_138

(DOI: 10.1248/bpbreports.3.4_138) Mariko Nakamoto, Yuna Yun, Mariko Omine, Sarasa Mori, Emi Shuto, Akiko Nakamoto, Akiko Hata, Nanako Aki, Yosuke Shikama, Yukiko Bandou, Takako Ichihara, Takako Minagawa, Ayako Tamura, Yumi Kuwamura, Makoto Funaki and Tohru Sakai :
Dietary diversity and characteristics of lifestyle and awareness of health in Japanese workers:a cross-sectional study.,
The Journal of Medical Investigation : JMI, Vol.67, No.3.4, 255-264, 2020.

(要約): The aim of this study was to clarify the characteristics of lifestyle and health awareness according to dietary diversity in a Japanese worksite population. The participants were 1,312 men and women aged 20 to 63 years who were living in Tokushima Prefecture, Japan during the period 2012-2013. We obtained anthropometric data and information on lifestyle characteristics using a self-administered questionnaire. Dietary intake was assessed using a food frequency questionnaire, and dietary diversity was determined using the Quantitative Index for Dietary Diversity (QUANTIDD). The characteristics of lifestyle and health awareness according to quartiles of the QUANTIDD score were assessed using the chi-square test and a general linear model. The higher the QUANTIDD score was, the larger were the proportions of participants who knew the appropriate amount of dietary intake and participants who referred to nutritional component information when choosing and / or buying food. Among participants with higher QUANTIDD scores, the proportion of participants who considered their current diet was good was high in women, whereas the proportion of participants who wanted to improve their diet in the future was high in men. Those results indicate that higher dietary diversity was related to better characteristics of lifestyle and awareness of health. J. Med. Invest. 67 : 255-264, August, 2020.
(徳島大学機関リポジトリ): ● Metadata: 115420
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.67.255
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33148898; ● Search Scopus @ Elsevier (PMID): 33148898; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.67.255

(徳島大学機関リポジトリ: 115420, DOI: 10.2152/jmi.67.255, PubMed: 33148898) Maria Ulfa, Momoyo Azuma, Masami Satou, Takaaki Shimohata, Shiho Fukushima, Junko Kido, Mariko Nakamoto, Takashi Uebanso, Kazuaki Mawatari, Takahiro Emoto, Masatake Akutagawa, Yohsuke Kinouchi and Akira Takahashi :
Inactivation of Extended-spectrum β-Lactamase (ESBL)-producing Escherichia Coli by UVA-LED Irradiation System.,
The Journal of Medical Investigation : JMI, Vol.67, No.1-2, 163-169, 2020.

(要約): The prevalence of extended-spectrum β-lactamase (ESBL)-producing Escherichia coli is increasing rapidly and spreading worldwide, particularly in Asia, compared to other regions. In the last ten years, in our hospital, in particular, there has been a < 30% increase. To prevent the spread of ESBL in hospitals and the community, the ultraviolet (UV) A-light-emitting diode (LED) irradiation device was used to inactivate ESBL-E. coli in human livestock and the environment. ESBL-E. coli and E. coli bacterial samples were collected from patients at Tokushima University Hospital (Tokushima City, Japan). The UVA-LED irradiation system had 365 nm single wavelength, and the current of the circuit was set to 0.23 or 0.50 A consistently. Results demonstrated that UVA-LED was useful for the inactivation of ESBL-E. coli and E. coli. The minimum energy dosage required to inactivate ESBL-E. coli and E. coli was 40.76 J/cm2 (45 min) in the first type of UVA-LED and 38.85 J/cm2 (5 min) in the second type. There were no significant differences between ESBL-E. coli and E. coli. The inactivation of ESBL-E. coli was dependent on energy. These findings suggest that UVA-LED with 365 nm single wavelength could be useful for surface decontamination in healthcare facilities. J. Med. Invest. 67 : 163-169, February, 2020.
(徳島大学機関リポジトリ): ● Metadata: 114642
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.67.163
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32378601; ● Summary page in Scopus @ Elsevier: 2-s2.0-85084329310

(徳島大学機関リポジトリ: 114642, DOI: 10.2152/jmi.67.163, PubMed: 32378601, Elsevier: Scopus) Mami Mitani, Yuki Minatogawa, Akiko Nakamoto, Mariko Nakamoto, Emi Shuto, Yoshitaka Nii and Tohru Sakai :
Sudachitin, polymethoxyflavone from Citrus sudachi, enhances antigen-specific cellular and humoral immune responses in BALB/c mice.,
Journal of Clinical Biochemistry and Nutrition, Vol.64, No.2, 158-163, 2019.

(出版サイトへのリンク): ● Publication site (DOI): 10.3164/jcbn.18-70
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30936628; ● Summary page in Scopus @ Elsevier: 2-s2.0-85064387091

(DOI: 10.3164/jcbn.18-70, PubMed: 30936628, Elsevier: Scopus) Mariko Nakamoto, Mariko Omine, Yuna Yun, Emi Shuto, Akiko Nakamoto, Akiko Hata, Nanako Aki, Yosuke Shikama, Yukiko Bandou, Takako Ichihara, Takako Minagawa, Ayako Tamura, Yumi Kuwamura, Makoto Funaki and Tohru Sakai :
Associations of dietary diversity with allergic diseases in Japanese workers: a cross-sectional study.,
Asia Pacific Journal of Clinical Nutrition, Vol.28, No.4, 857-869, 2019.

(要約): The aim of this study was to determine the associations of dietary diversity with prevalences of allergic diseases. The participants were 1,317 men and women aged 20 to 63 years who were living in Tokushima Prefecture, Japan during the period 2012-2013. We obtained anthropometric data and information on lifestyle characteristics and current medical histories of allergic diseases using a self-administered questionnaire. Dietary intake was assessed using a food frequency questionnaire, and dietary diversity was determined using the Quantitative Index for Dietary Diversity (QUANTIDD). The ORs and 95% CIs for each of the allergic diseases with a 1 standard deviation (SD) increase in the QUANTIDD score were estimated, controlling for age, family history of allergic diseases, education, smoking, drinking, physical activity, energy intake and BMI. Higher dietary diversity showed significant inverse dose-response relationships with allergic diseases and allergic rhinitis in women. Multivariate-adjusted ORs (95% CI) for allergic diseases and allergic rhinitis with 1 SD increase in the QUANTIDD score were 0.77 (95% CI: 0.60-0.98, p=0.037) and 0.69 (95% CI: 0.53-0.90, p=0.007), respectively, in women. There were no significant associations between dietary diversity and allergic diseases in men. The results indicate that there is an inverse association between higher dietary diversity and allergic rhinitis in Japanese female workers.
(キーワード): Adult / Asthma / Cross-Sectional Studies / Dermatitis, Atopic / Diet / Female / Food / Humans / Japan / Male / Middle Aged / Rhinitis, Allergic / Risk Factors / Young Adult
(出版サイトへのリンク): ● Publication site (DOI): 10.6133/apjcn.201912_28(4).0023
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31826384; ● Summary page in Scopus @ Elsevier: 2-s2.0-85076486533

(DOI: 10.6133/apjcn.201912_28(4).0023, PubMed: 31826384, Elsevier: Scopus) Mariko Nakamoto, Yukiko Tanaka, Satomi Ono, Akiko Nakamoto, Emi Shuto and Tohru Sakai :
Associations of marital and parental status and family members living together with health-related behaviors in Japanese young workers : a cross-sectional study.,
The Journal of Medical Investigation : JMI, Vol.66, No.1-2, 141-147, 2019.

(要約): The aim of this study was to clarify the associations of family members living together with healthrelated behaviors in Japanese young workers. The participants were 300 men and women aged 20-39 years in 2015 who had a job. A web-based self-administered questionnaire on status of partnering and parenting, number of family members living together, dietary habits, drinking habit, smoking habit, self-rated health, employment status, working time and commuting time was conducted through Internet. Multiple logistic regression analysis and general linear models were used to assess the association of family members living together with healthrelated behaviors. The multivariate-adjusted odds ratio (95% confidence interval, p-value) for current drinking in unmarried participants living with their parents compared to unmarried participants living alone was 0.35 (0.13-0.93, p=0.036). The adjusted means of frequency of breakfast skipping and frequency of eating out showed a trend for inverse associations with the presence of a partner and children. However, those associations disappeared after adjustment for age of youngest child. The findings suggest that the presence of parents might affect drinking behavior and that age of youngest child living together might affect the frequency of breakfast skipping in young Japanese workers. J. Med. Invest. 66 : 141-147, February, 2019.
(キーワード): 疫学 (epidemiology) / 栄養 (nutrition)
(徳島大学機関リポジトリ): ● Metadata: 113409
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.66.141
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31064927; ● Search Scopus @ Elsevier (PMID): 31064927; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.66.141

(徳島大学機関リポジトリ: 113409, DOI: 10.2152/jmi.66.141, PubMed: 31064927) Akiko Nakamoto, Mami Mitani, Kana Urayama, Akari Maki, Mariko Nakamoto, Emi Shuto, Yoshitaka Nii and Tohru Sakai :
Nobiletin Enhances Induction of Antigen-Specific Immune Responses in BALB/c Mice Immunized with Ovalbumin.,
Journal of Nutritional Science and Vitaminology, Vol.65, No.3, 278-282, 2019.

(出版サイトへのリンク): ● Publication site (DOI): 10.3177/jnsv.65.278
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31257269; ● Search Scopus @ Elsevier (PMID): 31257269; ● Search Scopus @ Elsevier (DOI): 10.3177/jnsv.65.278

(DOI: 10.3177/jnsv.65.278, PubMed: 31257269) Hirokazu Uemura, Sakurako Katsuura-Kamano, Mariko Nakamoto, Miwa Yamaguchi, Miho Fujioka, Yuki Iwasaki and Kokichi Arisawa :
Inverse association between soy food consumption, especially fermented soy products intake and soy isoflavone, and arterial stiffness in Japanese men.,
Scientific Reports, Vol.8, No.1, 9667, 2018.

(要約): Studies on the associations between soy food consumption and arterial stiffness are rare. The aim of the present study was to evaluate their associations in Japanese men. A total of 652 eligible men, aged 35-69 years, who underwent the measurement of brachial-ankle pulse wave velocity (baPWV) as an index of arterial stiffness were evaluated in this cross-sectional study. Information on their lifestyle characteristics, including dietary behavior, was obtained from a structured self-administered questionnaire. The frequency of total soy products as well as fermented and non-fermented soy products intakes was calculated, and the amounts of soy protein and soy isoflavone intakes were also estimated; these were then divided into tertiles and their associations with baPWV values were evaluated using general linear models. Higher frequency of fermented soy products intake was associated with decreased baPWV after adjusting for the multivariable covariates (P value for trend was 0.002, in Model 3). This association did not alter after further adjustment with a biomarker of systemic inflammation (serum high-sensitivity C-reactive protein (hs-CRP)) (P value for trend was 0.001, in Model 4). Total soy isoflavone consumption was also inversely associated with baPWV even after adjusting for multivariable covariates including serum hs-CRP (P value for trend was 0.043, in Model 4); however total soy protein consumption was not. These results demonstrated that greater consumption of soy food, especially fermented soy products and soy isoflavone was associated with reduced arterial stiffness, independent of systemic inflammation, in Japanese men.
(徳島大学機関リポジトリ): ● Metadata: 112443
(出版サイトへのリンク): ● Publication site (DOI): 10.1038/s41598-018-28038-0
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29941884; ● Search Scopus @ Elsevier (PMID): 29941884; ● Search Scopus @ Elsevier (DOI): 10.1038/s41598-018-28038-0

(徳島大学機関リポジトリ: 112443, DOI: 10.1038/s41598-018-28038-0, PubMed: 29941884) Tirani Bahari, Hirokazu Uemura, Sakurako Katsuura-Kamano, Miwa Yamaguchi, Mariko Nakamoto, Keisuke Miki, Masashi Ishizu and Kokichi Arisawa :
Nutrient-derived dietary patterns and their association with metabolic syndrome in a Japanese population,
Journal of Epidemiology, Vol.28, No.4, 194-201, 2018.

(要約): Nutrients have been proposed to be related to metabolic syndrome (MetS). The aims of this study were to identify dietary patterns that correlated with several nutrients using reduced rank regression (RRR) and to examine the association between extracted dietary patterns and prevalence of MetS in a Japanese population. The study population comprised 1,092 Japanese men and women (35-69 years old) who had participated in the baseline survey of the Japan Multi-Institutional Collaborative Cohort Study in Tokushima Prefecture. Dietary patterns were derived with RRR using 46 food items as predictors and six established nutrients (potassium, calcium, vitamin D, vitamin C, insoluble dietary fiber, and carotene) as response variables. Associations between extracted dietary patterns and MetS were then examined with logistic regression models. Among the six dietary patterns, dietary pattern 1 (DP1) explained the largest proportion (60.1%) of variance in the six nutrients. Therefore, only DP1 was selected for further analysis. DP1 was characterized by high intake frequency of vegetables, fruits, fish and small fish, natto (fermented soybeans), and deep-fried tofu. After adjustment for potential confounders, significant inverse associations were found between DP1 score and MetS (odds ratio [OR] for each quartile: 1.00, 0.58, 0.60, 0.52; P = 0.02); DP1 and high blood pressure (P = 0.0002); and DP1 and high blood glucose (P = 0.02). A dietary pattern characterized by high intake of vegetables, fruits, fish and small fish, natto, and deep-fried tofu was associated with reduced prevalence of MetS in a Japanese population.
(キーワード): Adult / Aged / Cohort Studies / Feeding Behavior / Female / Food / Humans / Japan / Male / Metabolic Syndrome / Middle Aged / Prevalence
(徳島大学機関リポジトリ): ● Metadata: 110919
(出版サイトへのリンク): ● Publication site (DOI): 10.2188/jea.JE20170010
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29151477; ● Search Scopus @ Elsevier (PMID): 29151477; ● Search Scopus @ Elsevier (DOI): 10.2188/jea.JE20170010

(徳島大学機関リポジトリ: 110919, DOI: 10.2188/jea.JE20170010, PubMed: 29151477) Mariko Nakamoto, Rei Otsuka, Yukiko Nishita, Chikako Tange, Makiko Tomida, Yuki Kato, Tomoko Imai, Tohru Sakai, Fujiko Ando and Hiroshi Shimokata :
Soy food and isoflavone intake reduces the risk of cognitive impairment in elderly Japanese women.,
European Journal of Clinical Nutrition, Vol.27, No.6, 1458-1462, 2018.

(要約): Data were derived from the National Institute for Longevity Sciences-Longitudinal Study of Aging. Subjects comprised 403 men and 373 women aged 60-81 years at baseline who participated in the follow-up study at least once. Bean, soy product and soy isoflavone intake was assessed using a 3-day dietary record at baseline. Cognitive function was assessed by the Mini-Mental State Examination (MMSE). MMSE scores of 23 were used to define cognitive impairment. The relationship between bean, soy product and soy isoflavone intake and cognitive impairment was assessed using a generalized estimating equation. Multivariate-adjusted odds ratios (95% confidence intervals) for cognitive impairment with a 1 s.d. increase in total bean, total soybean and total soy isoflavone intakes were 0.48 (0.28-0.81; p = 0.006), 0.51 (0.32-0.83; p = 0.007), and 0.55 (0.32-0.93; p = 0.026), respectively, in women. Total soybean and soy isoflavone intake might decrease the risk of cognitive impairment in elderly Japanese women.
(キーワード): 栄養 (nutrition) / 疫学 (epidemiology) / 認知症 (dementia)
(出版サイトへのリンク): ● Publication site (DOI): 10.1038/s41430-017-0061-2
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29348624; ● Summary page in Scopus @ Elsevier: 2-s2.0-85040678215

(DOI: 10.1038/s41430-017-0061-2, PubMed: 29348624, Elsevier: Scopus) Sakurako Katsuura-Kamano, Hirokazu Uemura, Miwa Yamaguchi, Mariko Nakamoto, Tirani Bahari, Keisuke Miki, Masashi Ishizu, Fusakazu Sawachika and Kokichi Arisawa :
Dietary calcium intake is associated with serum high-sensitivity C-reactive protein level in the general Japanese population,
Journal of Clinical Biochemistry and Nutrition, Vol.62, No.1, 89-93, 2018.

(要約): The beneficial effects of dietary calcium intake on high-sensitivity C-reactive protein levels, a risk factor of cardiovascular disease, have not been fully elucidated. This study investigated the associations between dietary calcium intake and serum high-sensitivity C-reactive protein levels in the general Japanese population. We analyzed the data of 2,019 subjects (1,194 men and 825 women) aged 35 to 69 years in a cross-sectional study of the Japan Multi-Institutional Collaborative Cohort Study. Nutrients intake including calcium were estimated using a validated food-frequency questionnaire. Analysis using a general linear model revealed that dietary calcium intake was inversely associated with serum high-sensitivity C-reactive protein levels ( for trend <0.001) after adjustment for age, sex, research group, leisure-time physical activity, smoking habit, drinking habit, dietary intakes (energy, dietary fiber, saturated fatty acids and vitamin D) and menopausal status. The association was slightly attenuated after additional adjustment for body mass index; however, remained significant ( for trend = 0.008). There were no significant interactions between dietary calcium intakes and sex, body mass index, or vitamin D intake for high-sensitivity C-reactive protein levels. This study have demonstrated that dietary calcium intake was inversely associated with serum high-sensitivity C-reactive protein levels in the general population.
(徳島大学機関リポジトリ): ● Metadata: 111900
(出版サイトへのリンク): ● Publication site (DOI): 10.3164/jcbn.17-48
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29371759; ● CiNii @ 国立情報学研究所 (CRID): 1390282679650033664; ● Search Scopus @ Elsevier (PMID): 29371759; ● Search Scopus @ Elsevier (DOI): 10.3164/jcbn.17-48

(徳島大学機関リポジトリ: 111900, DOI: 10.3164/jcbn.17-48, PubMed: 29371759, CiNii: 1390282679650033664) Mariko Nakamoto, Emi Shuto, Akiko Nakamoto, Akiko Hata, Nanako Aki, Yosuke Shikama, Yukiko Bandou, Takako Ichihara, Takako Minagawa, Ayako Tamura, Yumi Kuwamura, Makoto Funaki and Tohru Sakai :
Soy product and isoflavone intake associations with allergic diseases in Japanese workers: rhinitis, dermatitis and asthma.,
Asia Pacific Journal of Clinical Nutrition, Vol.27, No.6, 1277-1285, 2018.

(要約): The aim of this study was to determine the associations of intake of soy products and isoflavones with allergic diseases. We conducted a cross-sectional study in 1437 participants (aged 20-64 years) who were living in Tokushima Prefecture, Japan during the period 2010- 2011. We obtained anthropometric data and information on life style characteristics including dietary intake and current medical histories of allergic diseases using a structural self-administered questionnaire. Multiple logistic regression models were used to assess the associations of soy products and isoflavones with allergic diseases after controlling for age, family history of allergic diseases, smoking, drinking, physical activity, energy intake, BMI and dietary factors. Intake of soy products showed significant inverse dose-response relationships with allergic rhinitis. The third quartile for soy products had an adjusted OR of 0.56 (95% CI: 0.35-0.91) compared to the reference group (first quartile), though intake of soy products showed no dose-response relationship with atopic dermatitis. Intake of soy isoflavones showed a significant inverse dose-response relationship with atopic dermatitis, though the association between intake of soy isoflavones and atopic dermatitis was U-shaped after adjustments for potential confounders. On the other hand, the associations between intake of soy isoflavones and other allergic diseases were not significant. The results indicate that higher intake of soy products is associated with reduced risk of allergic rhinitis in Japanese workers. Furthermore, moderate intake amounts of soy products and soy isoflavones are associated with inverse risk of atopic dermatitis.
(キーワード): 疫学 (epidemiology) / 栄養 (nutrition)
(出版サイトへのリンク): ● Publication site (DOI): 10.6133/apjcn.201811_27(6).0015
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30485927; ● Search Scopus @ Elsevier (PMID): 30485927; ● Search Scopus @ Elsevier (DOI): 10.6133/apjcn.201811_27(6).0015

(DOI: 10.6133/apjcn.201811_27(6).0015, PubMed: 30485927) Xiaolin Yang, Mariko Nakamoto, Emi Shuto, Akiko Hata, Nanako Aki, Yosuke Shikama, Yukiko Bandou, Takako Ichihara, Takako Minagawa, Yumi Kuwamura, Ayako Tamura, Hirokazu Uemura, Kokichi Arisawa, Makoto Funaki and Tohru Sakai :
Associations between intake of dietary fermented soy food and concentrations of inflammatory markers: a cross-sectional study in Japanese workers,
The Journal of Medical Investigation : JMI, Vol.65, No.1-2, 74-80, 2018.

(要約): Epidemiological investigations have shown that consumption of soybeans or soy foods reduces the risk of the development of cardiovascular disease, cancer and osteoporosis. The aim of this study was to determine the associations between different soy foods and inflammatory markers, including high-sensitivity C-reactive protein (hs-CRP), interleukin (IL)-6, and IL-18, in Japanese workers. The cross-sectional study included 1,426 Japanese workers (1,053 men and 373 women) aged 20 to 64 years. Intake of 12 soy foods was estimated by a validated food frequency questionnaire. Associations of total soy foods, fermented soy food, non-fermented soy food, soy isoflavone with hs-CRP, IL-6, and IL-18 levels were examined by general linear model regression analysis. We found that total fermented soy food intake was inversely associated with multivariable-adjusted geometric concentration of IL-6 in men (Q1:1.03 pg/mL, Q5:0.94 pg /mL;P for trend = 0.031). Furthermore, it was shown that IL-6 concentrations were inversely associated with miso intake (β = -0.068;p = 0.034) and soy sauce intake in men (β = -0.074;p = 0.018). This study suggests that intake of total fermented soy food, miso and soy sauce be associated with IL-6 concentrations in Japanese men. J. Med. Invest. 65:74-80, February, 2018.
(徳島大学機関リポジトリ): ● Metadata: 111414
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.65.74
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29593198; ● CiNii @ 国立情報学研究所 (CRID): 1390282679224674560; ● Summary page in Scopus @ Elsevier: 2-s2.0-85044467994

(徳島大学機関リポジトリ: 111414, DOI: 10.2152/jmi.65.74, PubMed: 29593198, CiNii: 1390282679224674560, Elsevier: Scopus) Tirani Bahari, Hirokazu Uemura, Sakurako Katsuura-Kamano, Miwa Yamaguchi, Mariko Nakamoto, Keisuke Miki, Fusakazu Sawachika and Kokichi Arisawa :
Association between Dietary Patterns and Serum Adiponectin: A Cross-Sectional Study in a Japanese Population,
International Journal of Food Sciences and Nutrition, 1-10, 2017.

(要約): The aim of this study was to evaluate the associations between dietary pattern, adiponectin and insulin resistance. The study population consisted of 612 men and women aged 35-69 years old who had participated in the baseline survey of Japan Multi-Institutional Collaborative Cohort (J-MICC) Study in Tokushima Prefecture. Diets and lifestyle related variables were assessed by questionnaires. Multiple regression analyses were used to analyse the relations between dietary patterns and high molecular weight (HMW) adiponectin. For further analysis, path analysis was used to test the hypothesised model of association between dietary pattern, serum adiponectin and insulin resistance. The result showed that higher score of bread and dairy pattern was directly associated with increased serum level of adiponectin in women, which was inversely related to homeostasis model assessment of insulin resistance (HOMA-IR). In conclusion, higher consumption of bread and dairy products, and low intake of rice may be associated with increased serum adiponectin in women.
(徳島大学機関リポジトリ): ● Metadata: 111912
(出版サイトへのリンク): ● Publication site (DOI): 10.1080/09637486.2017.1338249
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28637371; ● Search Scopus @ Elsevier (PMID): 28637371; ● Search Scopus @ Elsevier (DOI): 10.1080/09637486.2017.1338249

(徳島大学機関リポジトリ: 111912, DOI: 10.1080/09637486.2017.1338249, PubMed: 28637371) Rei Otsuka, Yukiko Nishita, Chikako Tange, Makiko Tomida, Yuki Kato, Mariko Nakamoto, Fujiko Ando, Hiroshi Shimokata and Takao Suzuki :
The effect of modifiable healthy practices on higher-level functional capacity decline among Japanese community dwellers.,
Preventive Medicine Reports, Vol.5, 205-209, 2017.

(要約): This study aimed to clarify the effects of the accumulation of 8 modifiable practices related to health, including smoking, alcohol drinking, physical activity, sleeping hours, body mass index, dietary diversity, (life worth living), and health checkup status, on higher-level functional capacity decline among Japanese community dwellers. Data were derived from the National Institute for Longevity Sciences - Longitudinal Study of Aging. Subjects comprised 1269 men and women aged 40 to 79 years at baseline (1997-2000) who participated in a follow-up postal survey (2013). Higher-level functional capacity was measured using the Tokyo Metropolitan Institute of Gerontology Index of Competence (total score and 3 subscales: instrumental self-maintenance, intellectual activity, and social role). The odds ratio (OR) and 95% confidence interval (CI) for a decline in higher-level functional capacity in the follow-up study according to the total number of healthy practices were analyzed using the lowest category as a reference. Multivariate adjusted ORs (95% CIs) for the total score of higher-level functional capacity, which declined according to the total number of healthy practices (0-4, 5-6, 7-8 groups) were 1.00 (reference), 0.63 (0.44-0.92), and 0.54 (0.31-0.94). For the score of social role decline, multivariate adjusted ORs (95% CIs) were 1.00 (reference), 0.62 (0.40-0.97), and 0.46 (0.23-0.90), respectively (P for trend = 0.04). Having more modifiable healthy practices, especially in social roles, may protect against a decline in higher-level functional capacity among middle-aged and elderly community dwellers in Japan.
(徳島大学機関リポジトリ): ● Metadata: 115690
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.pmedr.2016.12.022
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28070478; ● Search Scopus @ Elsevier (PMID): 28070478; ● Search Scopus @ Elsevier (DOI): 10.1016/j.pmedr.2016.12.022

(徳島大学機関リポジトリ: 115690, DOI: 10.1016/j.pmedr.2016.12.022, PubMed: 28070478) Tohru Sakai, Miyuki Ohhata, Misaki Fujii, Sayaka Oda, Yasuna Kusaka, Miki Matsumoto, Akiko Nakamoto, Tomoyo Taki, Mariko Nakamoto and Emi Shuto :
Brazilian Green Propolis Promotes Weight Loss and Reduces Fat Accumulation in C57BL/6 Mice Fed A High-Fat Diet,
Biological & Pharmaceutical Bulletin, Vol.40, No.4, 391-395, 2017.

(要約): Propolis is a bee product with various biological properties. C57BL/6 mice were fed a high-fat diet and treated with propolis for 14 weeks. Body weight in mice treated with 2% propolis was less than that in control mice from 3 weeks after the start of treatment until 14 weeks except for the 7th week. Mice treated with propolis showed significantly lower epididymal fat weight and subcutaneous fat weight. Infiltration of epididymal fat by macrophages and T cells was reduced in the propolis group. Supplementation of propolis increased feces weight and fat content in feces, suggesting that mechanisms of weight reduction by propolis partly include a laxative effect and inhibition of fat absorption.
(キーワード): propolis / weight / fat absorption
(出版サイトへのリンク): ● Publication site (DOI): 10.1248/bpb.b16-00577
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28381793; ● Summary page in Scopus @ Elsevier: 2-s2.0-85016978833

(DOI: 10.1248/bpb.b16-00577, PubMed: 28381793, Elsevier: Scopus) Hitomi Kobayashi, Mami Mitani, Yuka Minatogawa, Satoko Hayashi, Mariko Nakamoto, Emi Shuto, Yoshitaka Nii and Tohru Sakai :
Extracts of citrus Sudachi peel attenuate body weight gain in C57BL/6 mice fed a high-fat diet,
The Journal of Medical Investigation : JMI, Vol.64, No.1.2, 20-23, 2017.

(要約): Citrus Sudachi is the special local product of Tokushima Prefecture, and over 98% of Sudachi consumed in Japan every year is produced in Tokushima Prefecture. In this study, we evaluated the function of sudachi peel extract (SPE) using an animal model of obesity. C57BL/6 mice were fed a high-fat diet containing 1% SPE powder. Treatment with SPE significantly decreased body weight compared to that of mice fed a high-fat diet. A significant difference in body weight was observed between the control and SPE groups from 7 weeks after the start of the experiment, the significant difference continued until the end of the 14-week experiment. Reduction of blood glucose levels following insulin administration in SPE-treated mice was grater than that in control mice. Determination of mRNA expression in adipose tissue showed that the expression level of TNF-α in the SPE group was significantly decreased compared to that on the control group. These results suggest that SPE potentially has the ability to attenuate body weight gain. J. Med. Invest. 64: 20-23, February, 2017.
(キーワード): Citrus sudachi / high-fat diet / inflammation / weight
(徳島大学機関リポジトリ): ● Metadata: 111075
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.64.20
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28373623; ● Search Scopus @ Elsevier (PMID): 28373623; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.64.20

(徳島大学機関リポジトリ: 111075, DOI: 10.2152/jmi.64.20, PubMed: 28373623) Rei Otsuka, Yukiko Nishita, Chikako Tange, Makiko Tomida, Yuki Kato, Mariko Nakamoto, Tomoko Imai, Fujiko Ando and Hiroshi Shimokata :
Dietary diversity decreases the risk of cognitive decline among Japanese older adults,
Geriatrics & Gerontology International, Vol.17, No.6, 937-944, 2016.

(要約): To clarify the effectiveness of dietary diversity, calculated by dietary records, on cognitive decline. Data were derived from the National Institute for Longevity Sciences - Longitudinal Study of Aging. Participants comprised 298 men and 272 women aged 60-81 years at baseline (second wave) who participated in the follow-up study (third to seventh wave) at least once. Cognitive function was assessed with the Mini-Mental State Examination in all study waves. Dietary diversity was determined using the Quantitative Index for Dietary Diversity based on a 3-day dietary record in the second wave. Cumulative data among participants with a Mini-Mental State Examination score >27 in the second wave were analyzed using a generalized estimating equation. Multivariate adjusted odds ratios and 95% confidence intervals for Mini-Mental State Examination scores ≤27 in each study wave according to a 1 standard deviation (increase), or quartiles of the Quantitative Index for Dietary Diversity at baseline, were adjusted for sex, age, follow-up time, baseline Mini-Mental State Examination score, education, body mass index, annual household income, current smoking status, energy intake and disease history. Multivariate adjusted odds ratio for a decline in Mini-Mental State Examination score was 0.79 (95% CI 0.70-0.89; P < 0.001) with a 1 SD increase in dietary diversity score, or 1.00 (reference), 0.99 (95% CI 0.70-1.43), 0.68 (95% CI 0.46-0.99) and 0.56 (95% CI 0.38-0.83) according to the lowest through highest quartiles of dietary diversity score, respectively (trend P = 0.001). Daily intake of various kinds of food might be a protective factor against cognitive decline in community-dwelling Japanese older adults. Geriatr Gerontol Int 2017; 17: 937-944.
(出版サイトへのリンク): ● Publication site (DOI): 10.1111/ggi.12817
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27380888; ● Summary page in Scopus @ Elsevier: 2-s2.0-85021091881

(DOI: 10.1111/ggi.12817, PubMed: 27380888, Elsevier: Scopus) Rei Otsuka, Yuki Kato, Yukiko Nishita, Chikako Tange, Makiko Tomida, Mariko Nakamoto, Tomoko Imai, Fujiko Ando and Hiroshi Shimokata :
Age-related changes in energy intake and weight in community-dwelling middle-aged and elderly Japanese,
The Journal of Nutrition, Health & Aging, Vol.20, No.4, 383-390, 2016.

(要約): This study attempts to describe trends in energy intake and weight change over 12 years according to age at first participation in the study. Prospective cohort study. The National Institute for Longevity Sciences - Longitudinal Study of Aging (NILS-LSA), a community-based study. Participants included 922 men and 879 women who participated in the first study-wave (age 40-79 years) and also participated in at least one study-wave from the second to seventh study-wave. Each study-wave was conducted biennially. For individuals, the entire follow-up period was 12 years. Energy intake was calculated from 3-day dietary records with photographs. Weight and height were measured under a fasting state. To estimate linear changes in energy intake and weight over 12 years according to age at first study-wave, we used the mixed-effects model. Mean (SD) follow-up time and number of study-wave visits were 9.5 (3.7) years and 5.4 (1.8) times, respectively. The fixed effect of the interaction of age and time in energy intake and weight was statistically or marginally statistically significant both in men (p<0.01) and in women (p<0.06). In men, when energy intake was estimated according to age, the rate of decrease in energy intake increased from -6.8 to -33.8 kcal/year for ages 40-79 years. In women, the rate of decrease in energy intake slightly increased in older age groups (-9.1 to -16.7 kcal/year for ages 40-79 years). Weight increased in males in their 40s (0.07 kg/year from age 40) and started to decline by age 53. In women, weight started to decline around age 47 (-0.04 kg/year). Twelve-year longitudinal data showed energy intake declined both in men and women in their 40s, and the rate of decrease increased in older males. Weight started to decline in men in their mid-50s and women in their late 40s. Further studies that focus on energy intake and weight reduction are needed to prevent weight loss or underweight in an increasingly aging society.
(キーワード): Energy intake / weight / longitudinal study / Japanese
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s12603-016-0715-0
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26999237; ● Summary page in Scopus @ Elsevier: 2-s2.0-84961213604

(DOI: 10.1007/s12603-016-0715-0, PubMed: 26999237, Elsevier: Scopus) Rei Otsuka, Yuki Kato, Yukiko Nishita, Chikako Tange, Mariko Nakamoto, Makiko Tomida, Tomoko Imai, Fujiko Ando, Hiroshi Shimokata and Takao Suzuki :
Dietary diversity and 14-year decline in higher-level functional capacity among middle-aged and elderly Japanese.,
Nutrition, Vol.32, No.7 8, 784-789, 2016.

(要約): This study aimed to clarify the effects of dietary diversity on a decline in higher-level functional capacity among middle-aged and elderly subjects in Japan. Data were derived from the National Institute for Longevity Sciences - Longitudinal Study of Aging. Subjects comprised 1317 men and women aged 40 to 79 at baseline (1997-2000) who participated in a follow-up postal survey (2013). Higher-level functional capacity was measured using the Tokyo Metropolitan Institute of Gerontology index of competence (total score and 3 subscales). Dietary intake was assessed using a 3-d dietary record, and dietary diversity was determined using the Quantitative Index for Dietary Diversity (QUANTIDD). The odds ratios and 95% confidence intervals (CI) for a decline in higher-level functional capacity in the follow-up study according to quartiles of QUANTIDD at baseline were estimated, controlling for age, sex, higher-level functional capacity scores at baseline, body mass index, alcohol consumption, physical activity, depressive score, household income, education, smoking, and disease history. A total of 214 (16%), 145 (11%), 70 (5%), and 136 (10%) subjects showed a decline in total score for higher-level functional capacity (≥2), instrumental self-maintenance (≥1), intellectual activity (≥2), and social role (≥2), respectively. Multivariate-adjusted odds ratios (95% confidence intervals) for the score for intellectual activity decline according to the lowest through highest quartiles of QUANTIDD were 1.00 (reference), 0.47 (0.23-0.95), 0.44 (0.22-0.90), and 0.41 (0.20-0.83), respectively (P for trend = 0.06). Daily intake of various foods may protect against a decline in intellectual activity among middle-aged and elderly community dwellers in Japan.
(キーワード): Dietary diversity / higher-level functional capacity / middle-aged and elderly Japanese
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.nut.2016.01.022
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27068882; ● Summary page in Scopus @ Elsevier: 2-s2.0-84968731705

(DOI: 10.1016/j.nut.2016.01.022, PubMed: 27068882, Elsevier: Scopus) Mariko Nakamoto, Rei Otsuka, Atsumu Yuki, Yukiko Nishita, Chikako Tange, Makiko Tomida, Yuki Kato, Fujiko Ando, Hiroshi Shimokata and Takao Suzuki :
Higher gait speed and smaller sway area decrease the risk for decline in higher-level functional capacity among middle-aged and elderly women,
Archives of Gerontology and Geriatrics, Vol.61, No.3, 429-436, 2015.

(要約): This study assessed whether physical function can indicate a risk of decline in higher-level functional capacity. Data were derived from the National Institute for Longevity Sciences-Longitudinal Study of Aging. Subjects comprised 466 men and 495 women aged 40-79 years at baseline (1997-2000), whose total score for the Tokyo Metropolitan Institute of Gerontology Index of Competence (TMIG-IC) at baseline was 11 and who participated in the follow-up survey. Baseline physical function examination included grip strength, comfortable gait speed, and sway area with eyes open. A decline in higher-level functional capacity was defined as a 2-point decrease in the TMIG-IC score after 14 years. The odds ratios (OR) and 95% confidence intervals (CI) for decline in the TMIG-IC score for 14 years according to a 1-standard deviation (SD) increase in physical function measurements at baseline were estimated. Subjects with decreased TMIG-IC scores included 78 (16.7%) men and 80 (16.2%) women. In women, the multivariate-adjusted OR (95% CI) for a TMIG-IC score decrease with a 1-SD increase in comfortable gait speed was 0.68 (0.50-0.92; p=0.013), and that with a 1-SD increase in sway area with eyes open was 1.49 (1.17-1.90; p=0.001). Grip strength was not associated with TMIG-IC score decline. None of the physical performance measures affected TMIG-IC score declines in men. These results suggest that gait speed decreases and sway area increases might predict a risk of decline in higher-level functional capacity among middle-aged and elderly women.
(キーワード): Gait speed / Sway area / Higher-level functional capacity / Longitudinal study
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.archger.2015.08.001
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26302677; ● Summary page in Scopus @ Elsevier: 2-s2.0-84943371707

(DOI: 10.1016/j.archger.2015.08.001, PubMed: 26302677, Elsevier: Scopus) Mariko Nakamoto, Hirokazu Uemura, Tohru Sakai, Sakurako Katsuura-Kamano, Miwa Yamaguchi, Mineyoshi Hiyoshi and Kokichi Arisawa :
Inverse association between soy food consumption and insulin resistance in Japanese adults,
Public Health Nutrition, Vol.18, No.11, 2031-2040, 2015.

(要約): The purpose of the present study was to examine the association between soya food consumption and insulin resistance using baseline data of the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study in Tokushima, Japan. This cross-sectional study included 1274 subjects, aged 34-70 years at baseline, living in Tokushima Prefecture between 2008 and 2013. Fasting blood samples were collected and information on lifestyle characteristics including soya food intake and medical history were obtained using a structured self-administered questionnaire. The homeostasis model assessment of insulin resistance (HOMA-IR) was measured and those with HOMA-IR ≥ 2.5 were defined as having insulin resistance. Multiple logistic regression models were used to analyse the association between soya product intake and the prevalence of insulin resistance. Rural communities located in Tokushima Prefecture, Japan, between 2008 and 2013. A total of 1148 adults (565 men and 583 women), aged 34-70 years. The frequency of intake of miso soup, total non-fried soya products and total soya products showed significant inverse dose-response relationships with insulin resistance, after adjustments for potential confounders. When soya product intake was calculated as soya protein and isoflavone, the odds ratios of insulin resistance decreased significantly as the estimated intake of soya protein increased. Furthermore, significant inverse dose-response relationships were observed for total non-fried soya products and total soya products, after adjustment for total vegetable or total fibre consumption. The present results indicate that the intake of soya products and non-fried soya products is associated with reduced insulin resistance in the Japanese population.
(キーワード): isoflavone / 糖尿病 (diabetes) / インスリン抵抗性 (insulin resistance)
(出版サイトへのリンク): ● Publication site (DOI): 10.1017/S136898001400247X
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25382603; ● Summary page in Scopus @ Elsevier: 2-s2.0-84936988645

(DOI: 10.1017/S136898001400247X, PubMed: 25382603, Elsevier: Scopus) Tohru Sakai, Tomoyo Taki, Akiko Nakamoto, Shiho Tazaki, Mai Arakawa, Mariko Nakamoto, Rie Tsutsumi and Emi Shuto :
Dietary ribonucleic Acid suppresses inflammation of adipose tissue and improves glucose intolerance that is mediated by immune cells in C57BL/6 mice fed a high-fat diet.,
Journal of Nutritional Science and Vitaminology, Vol.61, No.1, 73-78, 2015.

(要約): Recent evidence suggests that immune cells play an important role in differentiation of inflammatory macrophages in adipose tissue, which contributes to systemic chronic inflammation. Dietary ribonucleic acid (RNA) has been shown to modulate immune function. We hypothesized that RNA affects immune cell function in adipose tissue and then improves inflammatory response in adipose tissue. C57/BL6 mice and recombination activating gene-1 (RAG-1) knockout mice on a C57BL/6 mice background were fed a high-fat diet containing 1% RNA for 12 wk. An oral glucose tolerance test was performed. Supplementation of dietary RNA in C57BL/6 mice fed a high-fat diet resulted in a smaller area under the curve (AUC) after oral glucose administration than that for control mice. The mRNA expression levels of inflammation-related cytokines in adipose tissue and serum interleukin-6 levels were reduced by dietary RNA supplementation. Interestingly, reduction of the AUC value by RNA supplementation was abolished in T and B cell-deficient RAG-1 knockout mice. These results indicate that RNA improves inflammation in adipose tissue and reduces the AUC value following oral glucose administration in a T and B cell-dependent manner.
(出版サイトへのリンク): ● Publication site (DOI): 10.3177/jnsv.61.73
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25994141; ● Summary page in Scopus @ Elsevier: 2-s2.0-84929733065

(DOI: 10.3177/jnsv.61.73, PubMed: 25994141, Elsevier: Scopus) Akiko Nakamoto, Emi Shuto, Rie Tsutsumi, Mariko Nakamoto, Yoshitaka Nii and Tohru Sakai :
Vitamin A Deficiency Impairs Induction of Oral Tolerance in Mice.,
Journal of Nutritional Science and Vitaminology, Vol.61, No.2, 147-153, 2015.

(要約): Oral tolerance is a phenomenon of induction of systemic unresponsiveness to antigens ingested by the oral route and loss of immune response. Studies have shown the importance of vitamin A in oral tolerance in vitro but not in an in vivo experimental model. Therefore, we carried out experiments to determine how vitamin A deficiency affects tolerance induction and the ability of mesenteric lymph node (MLN) CD11c(+) cells to induce regulatory T cells (Tregs). Immunological tolerance was induced by oral ovalbumin (OVA) administration in vitamin A-sufficient mice. OVA-specific antibody and cytokine production were significantly reduced. On the other hand, in vitamin A-deficient mice, both OVA-specific antibody and cytokine production were not suppressed by oral OVA administration. Regarding induction of Tregs, the conversion rate of Foxp3(+) cells from naïve CD4(+) cell by CD11c(+) cells was decreased in vitamin A-deficient mice. Our study indicates that vitamin A deficiency causes the breakdown of oral tolerance in vivo.
(出版サイトへのリンク): ● Publication site (DOI): 10.3177/jnsv.61.147
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26052145; ● Summary page in Scopus @ Elsevier: 2-s2.0-84930703907

(DOI: 10.3177/jnsv.61.147, PubMed: 26052145, Elsevier: Scopus) Hirokazu Uemura, Sakurako Katsuura-Kamano, Miwa Yamaguchi, Mariko Nakamoto, Mineyoshi Hiyoshi and Kokichi Arisawa :
Family history of stroke is potentially associated with arterial stiffness in the Japanese population.,
Archives of Cardiovascular Diseases, Vol.107, No.12, 654-663, 2014.

(要約): Studies on the association between family history of cardiovascular disease and arterial stiffness are rare. This study evaluated the possible relationship between family history of cardiovascular disease and arterial stiffness in the Japanese population, by measuring brachial-ankle pulse wave velocity (ba-PWV). A total of 1004 eligible subjects (664 men and 340 women) aged 35-69 years, who were enrolled in the baseline survey of a cohort study in Tokushima Prefecture (Japan) and who underwent ba-PWV measurement, were analysed. Information about their lifestyle characteristics and first-degree family histories of ischaemic heart disease (i.e. myocardial infarction or angina pectoris), stroke or hypertension were obtained from a structural self-administered questionnaire. Subjects of both sexes with a family history of stroke showed significantly higher multivariable-adjusted means of ba-PWV than those without that trait (P values were 0.001 in men and 0.002 in women), while those with a family history of ischaemic heart disease did not. Subjects of both sexes with a family history of hypertension showed significantly higher age-adjusted means of ba-PWV than those without that trait, although these differences disappeared after further adjusting for blood pressure or multivariable covariates. When family histories of these diseases were inserted simultaneously into the same model, these results did not alter substantially. A family history of stroke might be associated with increased arterial stiffness, independent of other known atherosclerotic risk factors, including hypertensive elements, in both sexes in the Japanese population.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.acvd.2014.07.047
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25241219; ● Search Scopus @ Elsevier (PMID): 25241219; ● Search Scopus @ Elsevier (DOI): 10.1016/j.acvd.2014.07.047

(DOI: 10.1016/j.acvd.2014.07.047, PubMed: 25241219) Hirokazu Uemura, Sakurako Katsuura-Kamano, Miwa Yamaguchi, Mariko Nakamoto, Mineyoshi Hiyoshi and Kokichi Arisawa :
Association between dietary calcium intake and arterial stiffness according to dietary vitamin D intake in men.,
British Journal of Nutrition, Vol.112, No.8, 1333-1340, 2014.

(要約): Studies on the associations of dietary Ca and vitamin D intakes with arterial stiffness are scarce. In the present study, these associations were evaluated in Japanese men. Data from a total of 535 eligible men, aged 35-69 years, who participated in the baseline survey of a cohort study in Tokushima Prefecture, Japan, and underwent brachial-ankle pulse wave velocity (ba-PWV) measurements were analysed. ba-PWV is a measure of arterial stiffness and is recognised as a marker of atherosclerotic vascular damage. Information regarding the cohort's lifestyle characteristics including dietary behaviour over the past year was obtained from a structured self-administered questionnaire. Dietary Ca and vitamin D intakes were adjusted for total energy intake using the residual method and divided into quartiles; the highest quartile was used as the reference. General linear models were used to evaluate the associations between dietary Ca and vitamin D intakes and ba-PWV values adjusted for probable covariates. The association between dietary Ca intake and ba-PWV was further evaluated using similar general linear models stratified by dietary vitamin D intake (median or below/above median). Dietary Ca intake was found to be significantly inversely associated with ba-PWV after adjusting for probable covariates (P for trend = 0·020). However, no such association was observed between dietary vitamin D intake and ba-PWV. The inverse association between dietary Ca intake and ba-PWV was striking in subjects with higher dietary vitamin D intake. However, no association was found in subjects with lower dietary vitamin D intake. These results indicate that adequate dietary Ca and vitamin D intakes may be protective against the development of arterial stiffness in Japanese men.
(キーワード): Adult / Aged / Ankle Brachial Index / Atherosclerosis / Biological Markers / Calcium / Calcium, Dietary / Cohort Studies / Cross-Sectional Studies / Diet / Health Surveys / Humans / Japan / Male / Middle Aged / Prospective Studies / Pulse Wave Analysis / Risk Factors / Vascular Stiffness / Vitamin D / Vitamin D Deficiency
(出版サイトへのリンク): ● Publication site (DOI): 10.1017/S0007114514002153
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25192171; ● Search Scopus @ Elsevier (PMID): 25192171; ● Search Scopus @ Elsevier (DOI): 10.1017/S0007114514002153

(DOI: 10.1017/S0007114514002153, PubMed: 25192171) 酒井徹, 中本真理子, 中本晶子, 首藤恵泉, 小林ゆき子, 土居幸雄, 木戸康弘 :
管理栄養士・栄養士養成施設における教員の学位取得状況および教員に求められる知識や技能等に関する調査,
栄養学雑誌, Vol.72, No.5, 262-271, 2014年.

(要約): 【目的】管理栄養士および栄養士養成施設において管理栄養士・栄養士免許を有する教員の数，教員の学位取得状況，各養成施設において教員に求められる知識や技能等を明らかにする．【方法】教員の学位取得状況，教員に求められる知識や技能および担当科目等の基礎情報に関する質問用紙を作成し，2013年2∼3月に全国の管理栄養士および栄養士養成施設に郵送した．【結果】回答が得られた施設は，管理栄養士養成施設78校(回答率66.1%)，栄養士養成施設102校であった(回答率68.5%)．教員の年齢区分では管理栄養士および栄養士養成施設共に30∼49歳が最も高かった．管理栄養士養成施設で管理栄養士免許を有する教員で博士の学位を有する者の割合は年齢層が上昇するごとに増え30歳以上では約4割程度であった．管理栄養士養成施設において管理栄養士免許保有教員のうち修士または博士の学位を有するものは，20∼29歳42.5%，30∼49歳75.7%，50∼65歳66.5%であった．栄養士養成施設において管理栄養士免許を有する教員で博士の学位を有するものの割合は30歳以上で約2割程度であった．栄養士養成校において管理栄養士免許保有教員のうち修士および博士の学位を有するものは，20∼29歳28.4%，30∼49歳47.4%，50∼65歳42.0%であった．養成施設が教員に求める知識や技能に関しては，「教育」が最も高く，エフォートに対する割合としては50∼59%と回答する施設が最も多かった．【結論】管理栄養士および栄養士養成施設における管理栄養士または栄養士免許を有する教員の年齢構成，学位取得状況等の基本情報が得られた．また養成施設が教員に対して求める知識や技能として最も高いのは「教育」であった．
(キーワード): 管理栄養士・栄養士養成施設 / 教員 / 学位 / 知識・技能
(出版サイトへのリンク): ● Publication site (DOI): 10.5264/eiyogakuzashi.72.262
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390001206547275776; ● Search Scopus @ Elsevier (DOI): 10.5264/eiyogakuzashi.72.262

(DOI: 10.5264/eiyogakuzashi.72.262, CiNii: 1390001206547275776) Rei Otsuka, Yuki Kato, Yukiko Nishita, Chikako Tange, Mariko Nakamoto, Makiko Tomida, Tomoko Imai, Fujiko Ando and Hiroshi Shimokata :
Cereal intake increases and dairy products decrease risk of cognitive decline among elderly female Japanese.,
The Journal of Prevention of Alzheimer's Disease, Vol.1, No.3, 160-167, 2014.

(出版サイトへのリンク): ● Publication site (DOI): 10.14283/jpad.2014.29
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.14283/jpad.2014.29

(DOI: 10.14283/jpad.2014.29) Hirokazu Uemura, Sakurako Katsuura-Kamano, Miwa Yamaguchi, Mariko Nakamoto, Hiyoshi Mineyoshi, Sawachika Fusakazu and Kokichi Arisawa :
A family history of diabetes is not associated with arterial stiffness in non-diabetic Japanese population,
Open Journal of Epidemiology, Vol.3, No.4, Article-ID:39843,7pages, 2013.

(出版サイトへのリンク): ● Publication site (DOI): 10.4236/ojepi.2013.34025
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.4236/ojepi.2013.34025

(DOI: 10.4236/ojepi.2013.34025) Mariko Nakamoto, Kokichi Arisawa, Hirokazu Uemura, Sakurako Katsuura-Kamano, Hidenobu Takami, Fusakazu Sawachika, Miwa Yamaguchi, Tomoya Juta, Tohru Sakai, Eisaku Toda, Kei Mori, Manabu Hasegawa, Masaharu Tanto, Masayuki Shima, Yoshio Sumiyoshi, Kenji Morinaga, Kazunori Kodama, Takaichiro Suzuki, Masaki Nagai and Hiroshi Satoh :
Association between blood levels of PCDDs/PCDFs/dioxin-like PCBs and history of allergic and other diseases in the Japanese population.,
International Archives of Occupational and Environmental Health, Vol.86, No.8, 849-859, 2013.

(要約): Previous studies reported that exposure to dioxins was associated with an increased risk of various diseases in general populations. The aim of this study was to examine the association between levels of dioxins in blood and allergic and other diseases. We conducted a cross-sectional study on 1,063 men and 1,201 women (aged 15-76 years), who were living throughout Japan and not occupationally exposed to dioxins, during 2002-2010. In fasting blood samples, polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and dioxin-like PCBs (DL-PCBs) were analyzed by isotope dilution high-resolution gas chromatography/mass spectrometry. We obtained information on life style and self-reported history of diseases using a questionnaire. Blood pressure, blood levels of hemoglobin A1c, and serum lipids were also measured. Multiple logistic regression models were used to analyze the association between dioxin levels in blood and various diseases. Toxic equivalents of PCDDs/PCDFs and total dioxins showed significant inverse dose-response relationships with atopic dermatitis, after adjustments for potential confounders. The highest quartile for total dioxins had an adjusted odds ratio of 0.26 (95 % confidence interval 0.08-0.70) compared to the reference group (first quartile). The odds ratios for hypertension, diabetes mellitus, hyperlipidemia, gout in men, and gynecologic diseases in women significantly increased with increasing toxic equivalents of PCDDs/PCDFs, DL-PCBs, and total dioxins in blood. The present findings suggest that background exposure to dioxins was associated with reduced risk of atopic dermatitis. The results also support the idea that low-level exposure to dioxins is associated with an increased risk of diabetes, hypertension, and hyperlipidemia.
(キーワード): Adolescent / Adult / Aged / Benzofurans / Cross-Sectional Studies / Dermatitis, Atopic / Diabetes Mellitus / Environmental Exposure / Female / Humans / Hyperlipidemias / Hypertension / Japan / Life Style / Male / Middle Aged / Polychlorinated Biphenyls / Questionnaires / Tetrachlorodibenzodioxin / Young Adult
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s00420-012-0819-8
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23014754; ● Search Scopus @ Elsevier (PMID): 23014754; ● Search Scopus @ Elsevier (DOI): 10.1007/s00420-012-0819-8

(DOI: 10.1007/s00420-012-0819-8, PubMed: 23014754) Hirokazu Uemura, Sakurako Katsuura-Kamano, Miwa Yamaguchi, Mariko Nakamoto, M Hiyoshi and Kokichi Arisawa :
Abundant daily non-sedentary activity is associated with reduced prevalence of metabolic syndrome and insulin resistance.,
Journal of Endocrinological Investigation, 2013.

(要約): Background: Non-exercise activity thermogenesis (NEAT) has recently drawn attention because of its potential to prevent weight gain. Aim: This study evaluated the relationships between the duration of daily non-sedentary activities and the prevalence of metabolic syndrome and insulin resistance in the Japanese population. Material/Subjects and Methods: A total of 518 eligible subjects (380 men and 138 women) who attended the Tokushima Prefectural General Health Checkup Center and participated in the baseline survey of a cohort study conducted in Tokushima Prefecture, Japan were analyzed. Information about lifestyle characteristics including leisure-time exercise and daily non-exercise activities was obtained from a questionnaire. Logistic and multiple linear regression analyses were performed to evaluate the associations between the duration of daily non-exercise non-sedentary activities (beyond sitting) and prevalence of metabolic syndrome (and its components) and insulin resistance. Results: Subjects with longer duration of daily non-sedentary activities had significantly lower adjusted odds ratios for metabolic syndrome (P for trend = 0.024), abdominal obesity (P for trend = 0.023), and low HDL-cholesterol levels (P for trend = 0.002), after adjustment for sex, age, and other probable covariates including leisure-time exercise. Longer duration of daily non-sedentary activities was further associated with lower Homeostasis Model of Assessment-Insulin Resistance (HOMA-IR) values (P for trend = 0.009). Conclusions: Our results suggest that abundant daily non-sedentary activity might be associated with a lower prevalence of metabolic syndrome, especially for the components of central obesity and low HDL-cholesterol levels, and with a lower prevalence of insulin resistance, independent of leisure-time exercise.
(出版サイトへのリンク): ● Publication site (DOI): 10.3275/9066
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23886980; ● Search Scopus @ Elsevier (PMID): 23886980; ● Search Scopus @ Elsevier (DOI): 10.3275/9066

(DOI: 10.3275/9066, PubMed: 23886980) Hirokazu Uemura, Sakurako Katsuura-Kamano, Miwa Yamaguchi, Mariko Nakamoto, M Hiyoshi and Kokichi Arisawa :
Consumption of coffee, not green tea, is inversely associated with arterial stiffness in Japanese men.,
European Journal of Clinical Nutrition, 2013.

(要約): Background/Objectives:Studies on the associations between coffee and green tea consumption and arterial stiffness are rare. This study evaluated the possible relationships between coffee and green tea consumption and brachial-ankle pulse wave velocity (ba-PWV) values in Japanese men.Subjects/Methods:In total, 540 eligible men who enrolled in the baseline survey of a cohort study in Tokushima Prefecture, Japan, and who underwent ba-PWV measurement were analyzed. Information about lifestyle characteristics including coffee and green tea intake were obtained from a structural self-administered questionnaire. Multiple linear regression analyses were used to evaluate the associations between coffee and green tea consumption and ba-PWV.Results:Subjects with greater coffee consumption were younger and showed higher proportions of current smoking and alcohol consumption. Subjects with greater green tea consumption were older and showed lower proportions of current smoking and alcohol consumption. Greater coffee consumption was significantly inversely associated with ba-PWV after the adjustment for probable covariates, including serum low-density lipoprotein cholesterol and high-density lipoprotein cholesterol (P for trend =0.031). After additional adjustment for serum triglycerides, this inverse association persisted, but was somewhat attenuated (P for trend =0.050). In contrast, green tea consumption was not associated with ba-PWV.Conclusions:Coffee consumption was inversely associated with arterial stiffness independent of known atherosclerotic risk factors, and this association was partly mediated by reduced circulating triglycerides. Further prospective or interventional studies are needed to confirm the causal association.European Journal of Clinical Nutrition advance online publication, 17 July 2013; doi:10.1038/ejcn.2013.132.
(出版サイトへのリンク): ● Publication site (DOI): 10.1038/ejcn.2013.132
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23859993; ● Search Scopus @ Elsevier (PMID): 23859993; ● Search Scopus @ Elsevier (DOI): 10.1038/ejcn.2013.132

(DOI: 10.1038/ejcn.2013.132, PubMed: 23859993) Miwa Yamaguchi, Kokichi Arisawa, Hirokazu Uemura, Sakurako Katsuura-Kamano, Hidenobu Takami, Fusakazu Sawachika, Mariko Nakamoto, Tomoya Juta, Eisaku Toda, Kei Mori, Manabu Hasegawa, Masaharu Tanto, Masayuki Shima, Yoshio Sumiyoshi, Kenji Morinaga, Kazunori Kodama, Takaichiro Suzuki, Masaki Nagai and Hiroshi Satoh :
Consumption of seafood, serum liver enzymes, and blood levels of PFOS and PFOA in the Japanese population.,
Journal of Occupational Health, Vol.55, No.3, 184-194, 2013.

(要約): Perfluorooctanesulfonate (PFOS) and perfluorooctanoate (PFOA) have been shown to accumulate in the human body. The purpose of the present study was to examine the factors associated with the blood levels of PFOS and PFOA. A cross-sectional study was performed on 307 men and 301 women (aged 16-76 years) living in 15 prefectures in Japan. Blood levels of PFOS and PFOA were measured by liquid chromatography-mass spectrometry. Hepatic enzymes (-GTP, GOT, and GPT) and -3 polyunsaturated fatty acids (DHA and EPA) levels in serum were also measured. Associations between the levels of PFOS and PFOA in blood and the intake frequency of 41 kinds of dishes, foods and beverages and the serum levels of liver enzymes and -3 polyunsaturated fatty acids were examined using rank correlations. Frequency of intake of boiled fish in broth, sliced raw fish and coastal fish showed significant positive correlations with PFOS concentrations in blood after adjustments for potential confounders. Serum levels of GOT, GPT, DHA and EPA showed significant positive correlations with PFOS and PFOA in blood. There was also a significant regional difference in the blood levels of PFOS and 2013PFOA, with medians being highest in the Tokai/Hokuriku/Kinki region. These findings suggest that the concentrations of PFOS in blood were mainly associated with fish consumption and that the levels of PFOS and PFOA were associated with the serum levels of liver enzymes in Japanese populations. Further investigations are required to clarify the reason for the regional differences in blood levels of PFOS and PFOA in Japan.
(キーワード): Adolescent / Adult / Aged / Alanine Transaminase / Alkanesulfonic Acids / Aspartate Aminotransferases / Caprylates / Cross-Sectional Studies / Diet / Docosahexaenoic Acids / Eicosapentaenoic Acid / Environmental Exposure / Environmental Pollutants / Female / Fluorocarbons / Health Behavior / Humans / Japan / Liver / Male / Middle Aged / Residence Characteristics / Seafood / Young Adult / gamma-Glutamyltransferase
(徳島大学機関リポジトリ): ● Metadata: 105887
(出版サイトへのリンク): ● Publication site (DOI): 10.1539/joh.12-0264-OA
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23574777; ● Search Scopus @ Elsevier (PMID): 23574777; ● Search Scopus @ Elsevier (DOI): 10.1539/joh.12-0264-OA

(徳島大学機関リポジトリ: 105887, DOI: 10.1539/joh.12-0264-OA, PubMed: 23574777) 酒井徹, 中本真理子, 首藤恵泉, 保坂利男 :
栄養と免疫機能—非必須栄養素，低栄養状態，過栄養状態と免疫—,
四国医学雑誌, Vol.66, No.1, 19-26, 2010年.

(要約): It is known that nutritional state crucially affects immune function. In recent years, the contributionof the diet to the optimal working of the immune system has become wildly appreciatedand the influence of different dietary components on specific aspects of immune function has beenextensively studied. Soy isoflavone genistein suppresses antigen-specific immune response inBALB/c mice and suppresses development of atopic-like dermatitis in NC/Nga mice. In other soyisoflavone equol enhances antigen-specific IgE production via IL-13-mediated pathway. Further,equol exacerbates colitis of dextran sulfate sodium-treated mice. Therefore, immune stimulatoryeffects are strikingly different among soy isoflavones. In this reviews, in addition of the isoflavone,we overview the effects of dietary nucleic acid and protein-deficiency on antigen-specific immuneresponses. Furthermore, we present hot topics researches in the field of obesity and T cellfunction.
(キーワード): soy isoflavone / genistein / equol / 肥満症 (obesity) / T細胞 (T cell)
(徳島大学機関リポジトリ): ● Metadata: 110309
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1050001337465096832

(徳島大学機関リポジトリ: 110309, CiNii: 1050001337465096832)

MISC

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総説・解説

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講演・発表

Tirani Bahari, Hirokazu Uemura, Sakurako Kamano, Miwa Yamaguchi, Mariko Nakamoto, Masashi Ishizu, Miho Fujioka and Kokichi Arisawa :
Adherence to the Japanese Food Guide Spinning Top and Prevalence of Metabolic Syndrome and Its Components,
2017 International Congress of Diabetes & Metabolism, Seoul, Koria, Sep. 2017. Mariko Nakamoto, Rei Otsuka, Yukiko Nishita, Chikako Tange, Makiko Tomida, Yuki Kato, Tomoko Imai, Fujiko Ando and Hiroshi Shimokata :
Total bean intake reduces the risk of cognitive decline in female elderly Japanese,
Alzheimer's Association International Conference 2016, Toronto, Jul. 2016. Bahari Tirani, Hirokazu Uemura, Sakurako Katsuura-Kamano, Miwa Yamaguchi, Mariko Nakamoto, Miki Keisuke, Sawachika Fusakazu and Kokichi Arisawa :
Bread and Dairy Pattern is Associated with Increased Adiponectin Concentration among Japanese Adults.,
Vancouver, Canada, Dec. 2015. Rei Otsuka, Yuki Kato, Mariko Nakamoto, Tomoko Imai, Fujiko Ando and Hiroshi Shimokata :
Intake of meat and fish, and survival in community-dwelling Japanese males,
12th Asian Congress of Nutrition, May 2015. Mariko Nakamoto, Rei Otsuka, Yuki Kato, Yukiko Nishita, Chikako Tange, Makiko Tomida, Fujiko Ando and Hiroshi Shimokata :
Higher serum zinc level decreased the risk of cognitive decline in elderly Japanese women,
12th Asian Congress of Nutrition, May 2015.

(キーワード): serum zinc / cognitive decline / longitudinal study

Imaeda Nahomi, Wakai Kenji, Goto Chiho, Sakurako Kamano, Nanri Hinako, Hosono Satoyo, Oze Isao, Watanabe Miki, Fukuda Nana, Miwa Yamaguchi, Mariko Nakamoto, Tsunematsu-Nakahata Noriko, Tanaka Hideo and J-MICC Study Group :
Optimal food consumption among Japanese adults with adequate nutritional intake according to the Dietary Reference Intakes for Japanese,
the 20th IEA World Congress of Epidemiology, Anchorage, Aug. 2014. 中本真理子, 長島蓮梨, 田中由貴子, 小野里実, 岩崎夕貴, 中本晶子, 張姝, 木下かほり, 古屋かな恵, 今井具子, 大塚礼, 酒井徹 :
地域在住高齢者における日本食品成分表に基づく主要な13食品群の摂取頻度を用いた食事バランススコアの検討,
第34回日本疫学会学術総会, 2024年1月.

(キーワード): 地域在住高齢者 / 日本食品成分表 / 食事バランススコア

中本晶子, 竹内萌優, 中本真理子, 酒井徹 :
給食施設における使用済み布巾の殺菌方法とその効果に関する検討,
第18回日本給食経営管理学会学術総会, 2023年11月. 中本真理子, 中本晶子, 長谷川優花, 酒井徹 :
環境負荷に基づく食事の寄与食品群特性に関する検証,
第18回日本給食経営管理学会学術総会, 2023年11月.

(キーワード): 環境負荷 / 食事

虎見昂輝, 中本真理子, THUY THI BUI, 中本晶子, 酒井徹 :
若年者の空腹状態による食選択行動に及ぼす潜在的要因の影響,
第8回日本栄養改善学会四国支部学術総会, 2023年5月. 東條歩実, 中本真理子, 山田佳奈, 虎見昂輝, 中本晶子, 秦明子, 安藝菜奈子, 四釜洋介, 坂東由記子, 市原多香子, 南川貴子, 田村綾子, 桑村由美, 船木真理, 酒井徹 :
徳島県勤労者における食事摂取の多様性と炎症性マーカーとの横断的検討,
第8回日本栄養改善学会四国支部学術総会, 2023年5月. 酒井徹, 山本真子, 中本晶子, 中本真理子 :
ガン免疫チェックポイント療法に対する大豆イソフラボンの併用投与に関する研究,
第77回日本栄養・食糧学会大会, 295, 2023年5月. 中本晶子, 服部蒔季, 中本真理子, 酒井徹 :
抗炎症機構に対するポリメトキシフラボノイドの作用,
第77回日本栄養・食糧学会大会, 295, 2023年5月. 中本真理子, 東條歩実, 山田佳奈, 虎見昂輝, 中本晶子, 秦明子, 安藝菜奈子, 四釜洋介, 坂東由記子, 市原多香子, 南川貴子, 田村綾子, 桑村由美, 船木真理, 酒井徹 :
徳島県勤労者における食事摂取の多様性と炎症マーカーとの関連,
日本栄養・食糧学会誌, 74, 2023年5月. 中本真理子, 清水佑衣, 中本晶子, 酒井徹 :
管理栄養士養成課程の学生立案献立における食事多様性の高い献立の特徴,
第17回日本給食経営管理学会学術総会, 2022年11月. 山本真子, 中本晶子, 中本真理子, 八木田秀雄, 酒井徹 :
大豆イソフラボンのガン免疫チェックポイント療法への応用,
栄養学雑誌, Vol.80, No.5, 200, 2022年9月. 中本晶子, 守田栞捺, 中本真理子, 酒井徹 :
ノビレチンのサイトカイン産生調節作用を介した抗肥満効果,
栄養学雑誌, Vol.80, No.5, 195, 2022年9月. 中本真理子, 中本晶子, 酒井徹 :
管理栄養士養成課程の学生に対する給食経営管理実習が管理栄養士のコンピテンシーへ及ぼす影響,
栄養学雑誌, Vol.80, No.5, 186, 2022年9月.

(キーワード): 給食経営管理 / 給食 / 教育効果 / コンピテンシー / 管理栄養士

山田佳奈, 中本真理子, 中本晶子, 秦明子, 安藝菜奈子, 四釜洋介, 坂東由記子, 市原多香子, 南川貴子, 田村綾子, 桑村由美, 船木真理, 酒井徹 :
徳島県勤労者のイソフラボン摂取量とメタボリックシンドローム構成因子との関連,
栄養学雑誌, Vol.80, No.5, 207, 2022年9月.

(キーワード): 疫学 (epidemiology) / 公衆栄養 / 栄養疫学

中本晶子, 平林悠和, 中本真理子, 酒井徹 :
17型ヘルパーT細胞に対するポリメトキシフラボノイドの作用-In vitroおよびin vivo系での検討-,
第20回四国免疫フォーラム, 2022年6月. 山田佳奈, 中本真理子, 中本晶子, 秦明子, 安藝菜奈子, 四釜洋介, 坂東由記子, 市原多香子, 南川貴子, 田村綾子, 桑村由美, 船木真理, 酒井徹 :
徳島県勤労者の大豆イソフラボン摂取量とメタボリックシンドロームとの関連,
第264回徳島医学会学術集会, 32, 2022年2月. 中川利津代, 中本真理子 :
食品販売業者において栄養成分表示の義務化が加工食品の仕入れや販売等に与えた影響,
第80回日本公衆衛生学会総会, 2021年12月. 山田佳奈, 中本真理子, 中本晶子, 秦明子, 安藝菜奈子, 四釜洋介, 坂東由記子, 市原多香子, 南川貴子, 田村綾子, 桑村由美, 船木真理, 酒井徹 :
徳島県勤労者のイソフラボン摂取量とメタボリックシンドロームとの関連,
第6回日本糖尿病・生活習慣病ヒューマンデータ学会年次学術集会, 2021年12月. 竹井理恵, 首藤恵泉, 中本晶子, 中本真理子, 酒井徹 :
大豆イソフラボンの癌間細胞に及ぼす影響,
第54回日本栄養・食糧学会中国四国支部大会・第7回日本栄養改善学会四国支部学術総会合同大会, 2021年10月. 中川利津代, 犬伏知子, 中本真理子 :
一般加工食品への栄養成分表示の義務化において大学が果たす業者支援(地域貢献)についての一考察,
第54回日本栄養・食糧学会中四国支部大会・第7回日本栄養改善学会四国支部学術合同総会, 2021年10月. 山田佳奈, 中本真理子, 上村美玖, 吉田舞, 上ノ薗理乃, 中本晶子, 酒井徹 :
新型コロナウイルス感染拡⼤による高齢者の食選択動機及び食生活への影響,
第54回日本栄養・食糧学会中四国支部大会・第7回日本栄養改善学会四国支部学術合同総会, 2021年10月. 中本晶子, 中本真理子, 酒井徹 :
スダチ果皮由来精油成分が免疫細胞に及ぼす作用と抗原特異的免疫応答への影響,
第68回日本栄養改善学会学術総会, Vol.79, No.5, 107, 2021年10月. 中川利津代, 犬伏知子, 中本真理子 :
栄養成分表示の義務化がスーパーマーケットにおける商品数及び売上高に与えた影響,
第68回日本栄養改善学会学術総会, Vol.79, No.5, 98, 2021年10月. 中本真理子, 上村美玖, 吉田舞, 上ノ薗理乃, 山田佳奈, 中本晶子, 酒井徹 :
新型コロナウイルス感染拡大に伴う初回緊急事態宣言前後での高齢者の食選択動機及び食品摂取多様性の変化,
第68回日本栄養改善学会学術総会, Vol.79, No.5, 187, 2021年10月.

(キーワード): 疫学 (epidemiology) / 食選択動機 / 食生活 / 高齢者

平林悠和, 中本晶子, 安崎千咲里, 中本真理子, 首藤恵泉, 酒井徹 :
T細胞分化に与えるポリメトキシフラボノイドの影響,
第75回日本栄養・食糧学会大会, 27, 2021年7月. 平林悠和, 中本晶子, 安崎千咲里, 中本真理子, 首藤恵泉, 酒井徹 :
実験的自己免疫性脳脊髄炎(EAE)マウスに対するノビレチンの作用,
第53回日本栄養・食糧学会中国・四国支部大会, 13, 2020年10月. 中本真理子, 小野聖実, 田中由貴子, 中本晶子, 首藤恵泉, 酒井徹 :
徳島県の子育て世代におけるワークライフバランスと食行動の関係,
第67回日本栄養改善学会学術総会, Vol.78, No.5, 2020年9月. 中本晶子, 安崎千咲里, 平林悠和, 中本真理子, 首藤恵泉, 酒井徹 :
マクロファージに対するポリメトキシフラボンの作用-敗血症モデルマウスを用いた検討-,
第67回日本栄養改善学会学術総会, Vol.78, No.5, 67, 2020年9月. 中本晶子, 平林悠和, 安崎千咲里, 中本真理子, 首藤恵泉, 酒井徹 :
ノビレチンによる実験的自己免疫性脳脊髄炎(EAE)におけるT細胞機能への影響,
第74回日本栄養・食糧学会大会, 205, 2020年4月. 中本真理子, 大嶺茉利子, 尹優奈, 首藤恵泉, 中本晶子, 秦明子, 安藝菜奈子, 四釜洋介, 坂東由記子, 市原多香子, 南川貴子, 田村綾子, 桑村由美, 船木真理, 酒井徹 :
徳島県勤労者における食事摂取の多様性とアレルギー性疾患との関連,
四国公衆衛生学会雑誌, Vol.65, No.1, 32, 2020年2月.

(キーワード): 疫学 (epidemiology) / 栄養 (nutrition) / アレルギー (allergy) / 日本 (Japan)

中本晶子, 浦山佳菜, 安崎千咲里, 平林悠和, 中本真理子, 首藤恵泉, 酒井徹 :
ポリメトキシフラボンの免疫細胞に対する機能評価 -マクロファージおよび肥満細胞での解析-,
第66回日本栄養改善学会学術総会, 2019年9月. 浦山佳菜, 中本晶子, 安崎千咲里, 平林悠和, 中本真理子, 首藤恵泉, 酒井徹 :
免疫細胞に対するスダチ果皮フラボノイドの作用に関する研究-肥満細胞およびマクロファージにおける検討-,
第259回徳島医学会学術集会, 2019年8月. 中本晶子, 首藤恵泉, 中本真理子, 酒井徹 :
スダチ果皮に含まれるスダチチンのin vitroにおける機能評価 -マクロファージおよび肥満細胞での解析-,
第73回日本栄養・食糧学会大会, 2019年5月. 首藤恵泉, 中本真理子, 中本晶子, 酒井徹 :
エクオールの前駆脂肪細胞3T3-L1に対する作用,
第73回日本栄養・食糧学会大会, 2019年5月. 浦山佳菜, 中本晶子, 安崎千咲里, 平林悠和, 中本真理子, 首藤恵泉, 酒井徹 :
スダチ果皮フラボノイドの免疫細胞に対する作用に関する研究―肥満細胞およびマクロファージに対する作用―,
第6回日本栄養改善学会四国支部学術総会, 2019年4月. 首藤恵泉, 中本真理子, 中本晶子, 酒井徹 :
食餌誘導性肥満マウスにおけるエクオールの作用,
第65回日本栄養改善学会学術総会, 2018年9月. 中本晶子, 中本真理子, 首藤恵泉, 酒井徹 :
スダチチンおよびデメトキシスダチチンによる免疫調節作用,
第65回日本栄養改善学会学術総会, 2018年9月. 中本晶子, 中本真理子, 首藤恵泉, 酒井徹 :
デメトキシスダチチンの免疫調節作用,
第5回日本栄養改善学会四国支部学術総会, 2018年6月. 首藤恵泉, 國松真由香, 中本晶子, 中本真理子, 酒井徹 :
食餌誘導性肥満マウスにおけるエクオールの作用,
第72回日本栄養・食糧学会大会, 2018年5月. 中本晶子, 中本真理子, 首藤恵泉, 酒井徹 :
デメトキシスダチチンによる免疫調節作用,
第72回日本栄養・食糧学会大会, 2018年5月. 楊暁琳, 中本真理子, 酒井徹, 首藤恵泉, 篠原尚子, 秦明子, 南川貴子, 市原多香子, 田村綾子, 桑村由美, 船木真理 :
徳島県男性勤労者の大豆発酵食品摂取は血清IL-6濃度を低下させる,
第63回日本栄養改善学会学術総会, 2016年9月. 篠原尚子, 中本真理子, 酒井徹, 首藤恵泉, 楊暁琳, 秦明子, 南川貴子, 市原多香子, 田村綾子, 桑村由美, 船木真理 :
徳島県男性勤労者における珈琲，緑茶およびその他のお茶摂取と高尿酸血症との関連,
第63回日本栄養改善学会学術総会, 2016年9月. 中本真理子, 楊暁琳, 篠原尚子, 酒井徹 :
徳島県勤労者の婚姻・子供の有無と欠食行動との関係,
第63回日本栄養改善学会学術総会, 2016年9月. Takako Ichihara, Akiko Hata, Toshimi Onishi, Mariko Nakamoto, Emi Shuto, Tohru Sakai, Ayako Tamura, Takako Minagawa, Yukari Hisaka and Makoto Funaki :
Association between daily life activities and blood pressure increaseThree-year longitudinal study in Japanese male employees living in suburban cities,
The 6th Joint Symposium between Kagawa University and Chiang Mai University, Aug. 2016. 篠原尚子, 中本真理子, 酒井徹, 首藤恵泉, 楊暁琳, 秦明子, 安藝菜奈子, 四釜洋介, 板東由記子, 日坂ゆかり, 南川貴子, 田村綾子, 桑村由美, 市原多香子, 船木真理 :
徳島県男性勤労者におけるリスク保有状況別の嗜好飲料摂取と高尿酸血症の関連の検討,
第253回徳島医学会, 2016年7月. 三谷麻美, 中本真理子, 首藤恵泉, 酒井徹 :
スダチチンの免疫調節作用-卵白アルブミン免疫マウスモデルでの検討-,
第70回日本栄養・食糧学会大会, 2016年5月. 楊曉琳, 中本真理子, 酒井徹, 首藤恵泉, 篠原尚子, 秦明子, 安藝菜奈子, 小杉知里, 四釜洋介, 坂東由記子, 南川貴子, 市原多香子, 田村綾子, 桑村由美, 船木真理 :
徳島県勤労者を対象とした大豆摂取と炎症マーカーとの関連について,
第70回日本栄養食糧学会, 2016年5月. 篠原尚子, 中本真理子, 酒井徹, 首藤恵泉, 楊暁琳, 秦明子, 安藝菜奈子, 四釜洋介, 坂東由記子, 南川貴子, 市原多香子, 田村綾子, 桑村由美, 船木真理 :
徳島県勤労者における珈琲摂取と高尿酸血症との関連,
第70回日本栄養・食糧学会, 2016年5月. 中本真理子, 酒井徹, 首藤恵泉, 安藝菜奈子, 秦明子, 桑村由美, 南川貴子, 市原多香子, 田村綾子, 船木真理 :
徳島県勤労者のイソフラボン摂取量とアレルギー疾患との関係,
第70回日本栄養・食糧学会, 2016年5月. 國松真由香, 首藤恵泉, 三谷麻美, 中本真理子, 酒井徹 :
食餌誘導性肥満マウスにおけるエクオールの効果,
第70回日本栄養・食糧学会大会, 2016年5月. 篠原尚子, 中本真理子, 酒井徹, 首藤恵泉, 楊暁琳, 秦明子, 安藝菜奈子, 四釜洋介, 坂東由記子, 南川貴子, 市原多香子, 田村綾子, 桑村由美, 船木真理 :
第3回日本栄養改善学会(四国支部会),
第3回日本栄養改善学会(四国支部会), 2016年4月. Bahari Tirani, Hirokazu Uemura, Sakurako Katsuura-Kamano, Miwa Yamaguchi, Mariko Nakamoto, Miki Keisuke, Ishizu Masashi and Kokichi Arisawa :
Micronutrients Derived Dietary Pattern is Associated with Metabolic Syndrome in the J-MICC Study.,
第26回日本疫学会総会,2016年1月21-23日,鳥取, Jan. 2016. 楊曉琳, 中本真理子, 酒井徹, 鈴木公 :
中国雲南省昆明市における幼児体型の違いに基づく生活習慣・食習慣に関する実態調査,
第14回日本栄養改善学会近畿支部学術総会, 2015年12月.

(キーワード): 幼児 / 肥満 / 食習慣

中本真理子, 大塚礼, 安藤富士子, 下方浩史 :
地域在住中高年者の味噌摂取がその後の全死亡および癌死亡に及ぼす影響,
日本公衆衛生雑誌, Vol.62, No.10, 531, 2015年11月.

(キーワード): 味噌 / 癌 (cancer)

酒井徹, 中本真理子, 首藤恵泉 :
スダチ果皮による血糖上昇抑制作用の検討,
第62回日本栄養改善学会学術総会, 2015年9月. 首藤恵泉, 三谷麻実, 中本真理子, 酒井徹 :
食餌誘導性肥満マウスにおけるエクオールの効果,
第62回日本栄養改善学会学術総会, 2015年9月. 三谷麻実, 中本真理子, 首藤恵泉, 酒井徹 :
In vivo におけるスダチチンの免疫調節作用 -ALZET pumpを用いた検討-,
第62回日本栄養改善学会学術総会, 2015年9月. 中本真理子, 首藤恵泉, 三谷麻実, 酒井徹 :
豆乳摂取は若年者の心身ストレスを改善するか,
第62回日本栄養改善学会学術総会, 2015年9月. 小嶋汐美, 今枝奈保美, 南里妃名子, 中本真理子, 山口美輪, 釜野桜子, 後藤千穂, 岡本尚子, 鈴木美奈, 宮川尚子, 尾崎悦子, 栗原綾子, 矢口友里, 福田奈菜, 近藤文 :
秤量法食事記録調査による習慣的な摂取食品の男女別ポーションサイズに関する検討,
第62回日本栄養改善学会学術総会, 2015年9月. 今枝奈保美, 南里妃名子, 中本真理子, 山口美輪, 釜野桜子, 後藤千穂, 岡本尚子, 鈴木美奈, 小嶋汐美, 宮川尚子, 尾崎悦子, 栗原綾子, 矢口友理, 福田奈菜, 近藤文 :
日本の中高年におけるヨウ素の摂取状況―秤量法食事記録法のコード化ルールによる誤差の検討,
第62回日本栄養改善学会学術総会, 2015年9月. Mariko Nakamoto, Rei Otsuka, Atsumu Yuki, Yukiko Nishita, Chikako Tange, Makiko Tomida, Yuki Kato, Fujiko Ando, Hiroshi Shimokata and Takao Suzuki :
Gait speed and sway area predict decline in activities of daily living among middle-aged and elderly women.,
第25回日本疫学会学術総会, Jan. 2015. Rei Otsuka, Yuki Kako, Yukiko Nishita, Chikako Tange, Mariko Nakamoto, Makiko Tomida, Tomoko Imai, Fujiko Ando, Hiroshi Shimokata and Takao Suzuki :
Dietary diversity and 14-year decline in activities of daily living among middle-aged and elderly community dwellers.,
第25回日本疫学会学術総会, Jan. 2015. Tirani Bahari, Hirokazu Uemura, Sakurako Kamano, Miwa Yamaguchi, Mariko Nakamoto, Mineyoshi Hiyoshi and Kokichi Arisawa :
The Association between Dietary Pattern and Serum Adiponectin: A Cross Sectional Study In Japanese Population,
第25回日本疫学会学術総会, Jan. 2015. 中本真理子, 上村浩一, 釜野桜子, 山口美輪, 有澤孝吉 :
日本人における大豆製品摂取とインスリン抵抗性との関連に関する研究,
第59回四国公衆衛生学会総会・平成25年度四国公衆衛生研究発表会, 2014年2月. 上村浩一, 勝浦-釜野桜子, 山口美輪, 中本真理子, 有澤孝吉 :
日本人男性における食事からのカルシウム・ビタミンD摂取と動脈スティフネスとの関連,
第72回日本公衆衛生学会総会, 2013年10月. 山口美輪, 上村浩一, 釜野桜子, 中本真理子, 有澤孝吉 :
食習慣と睡眠と起床の規則性との関連,
第72回日本公衆衛生学会総会, 2013年10月. 上村浩一, 勝浦桜子, 山口美輪, 中本真理子, 高見栄喜, 十田朋也, 武田英雄, 有澤孝吉 :
動脈スティフネスに影響を及ぼす因子の検討~体格指標を中心に~．,
第70回日本公衆衛生学会総会, 2011年10月.

研究会・報告書

中本真理子 :
地域在住高齢者のエクオール産生能に基づく大豆製品摂取と認知機能との関係を探る調査研究,
公益財団法人不二たん白質研究振興財団第21回研究報告会, 2018年5月.

(キーワード): 認知症 (dementia) / 疫学 (epidemiology) / 栄養 (nutrition)

中本真理子, 酒井徹 :
豆乳摂取は若年者の身体的ストレス状態を改善する,
公益財団法人不二たん白質第18回研究報告会プログラム, 2015年5月. 塚崎晃士, 松井康素, 竹村真里枝, 原田敦, 中本真理子, 大塚礼, 安藤富士子, 下方浩史 :
大腿中央部CTのサルコペニア診断における有用性．,
第25回日本老年医学会東海地方会, 2014年10月. Mariko Nakamoto, Sarasa Mori, Emi Shuto, Akiko Nakamoto, Akiko Hata, Nanako Aki, Yosuke Shikama, Yukiko Bandou, Takako Ichihara, Takako Minagawa, Ayako Tamura, Yumi Kuwamura, Makoto Funaki and Tohru Sakai :
Soy and Isoflavone Intake and Lifestyle and Health Awareness in Japanese Workers,
SOY PROTEIN RESEARCH, Japan, Vol.24, 154-161, Jul. 2022. 中本真理子, 森更紗, 大河内章充, 首藤恵泉, 中本晶子, 秦明子, 安藝菜奈子, 四釜洋介, 坂東由記子, 市原多香子, 南川貴子, 田村綾子, 桑村由美, 船木真理, 酒井徹 :
大豆製品・大豆含有成分摂取と推定腎機能との関係を探る臨床疫学研究,
大豆たん白質研究, Vol.23, 182-191, 2020年. 中本真理子, 大塚礼, 加藤友紀, 安藤富士子, 下方浩史 :
地域在住中高年者における味噌および大豆製品摂取と癌による既往・死亡を探る大規模縦断疫学研究,
中央味噌研究所研究報告, No.38, 112-118, 2017年3月. 酒井徹, 中本真理子 :
味噌・大豆製品摂取とインスリン抵抗性およびメタボリックシンドローム構成因子との関係に関する縦断研究,
中央味噌研究所研究報告, No.38, 68-76, 2017年3月. 中本真理子, 酒井徹 :
地域在住高齢者のエクオール産生能に基づく大豆製品摂取と認知機能との関係を探る調査研究,
大豆たん白質研究, Vol.20, 165-172, 2017年.

(キーワード): 認知症 (dementia) / 疫学 (epidemiology) / 栄養 (nutrition)

中本真理子, 酒井徹 :
豆乳摂取は大学生のストレス状態を改善する,
大豆たん白質研究, Vol.36, No.18, 182-187, 2016年6月.

(キーワード): 豆乳 / ストレス (stress) / 大学生 / cross-over trial

特許: 研究者総覧に該当データはありませんでした。
作品: 研究者総覧に該当データはありませんでした。
補助金・競争的資金: 大豆摂取の記憶関連脳容積への影響－エストロゲン受容体遺伝子型を考慮した縦断研究 (研究課題/領域番号: 20K05925 )
フラボノイドメトキシ基の構造機能学解析-代謝ダイナミックスと癌免疫療法への新展開 (研究課題/領域番号: 19K11768 )
脂肪酸摂取からの認知機能低下予防－インスリン抵抗性・炎症の制御機構を介して (研究課題/領域番号: 15K19253 )
エストロゲン受容体遺伝子多型に基づく大豆製品摂取の認知機能に及ぼす影響の解明 (研究課題/領域番号: 15K16228 )
研究者番号（40722533）による検索

その他: 研究者総覧に該当データはありませんでした。

研究者総覧で最新データを確認する

2024年5月2日更新

専門分野・研究分野: 公衆栄養学 (Public Health Nutrition)
公衆衛生学 (Public Health)
栄養疫学
所属学会・所属協会: 公益社団法人日本栄養・食糧学会
日本栄養改善学会
日本食育学会
日本健康教育学会
日本公衆衛生学会
日本衛生学会
日本疫学会
委員歴・役員歴: 日本食育学会 ( [2010年〜2011年])
日本健康教育学会 ( [2010年4月〜2015年3月])
日本衛生学会 ( [2010年4月〜2015年3月])
日本食育学会 ( [2011年〜2012年])
受賞: 2012年3月, 徳島大学学生表彰 (徳島大学)
2012年9月, BEST Non English Speaking Background Poster (the International Congress of Dietetics in Sydney)
2013年1月, 康楽賞 (公益財団法人康楽会)
2013年3月, 徳島大学学生表彰 (徳島大学)
2019年1月, 岡奨学賞 (徳島大学医学部)
2021年3月, 医学部優秀教育賞 (徳島大学医学部)
活動: 徳島県食の安全安心審議会 (委員 [2013年8月〜2015年7月])
徳島県農林水産部とくしま水産創生ビジョン検討委員会 (委員 [2015年9月〜12月])
国立研究開発法人国立長寿医療研究センター (研究生 [2015年4月])

リサーチマップで最新データを確認するＪグローバルで最新データを確認する

2024年4月28日更新

2024年4月27日更新

Ｊグローバル

Jグローバル最終確認日: 2024/4/27 01:25
氏名（漢字）: 中本真理子
氏名（フリガナ）: ナカモトマリコ
氏名（英字）: Nakamoto Mariko
所属機関: 徳島大学講師
国立研究開発法人国立長寿医療研究センター研究生

リサーチマップ

researchmap最終確認日

2024/4/28 01:46

氏名（漢字）

中本真理子

氏名（フリガナ）

ナカモトマリコ

氏名（英字）

Nakamoto Mariko

プロフィール

2008年3月徳島大学医学部栄養学科卒業

2010年3月徳島大学大学院栄養生命科学教育部博士前期課程修了（修士(栄養学））

2013年3月徳島大学大学院栄養生命科学教育部博士後期課程修了（博士(栄養学））

2012年4月〜日本学術振興会特別研究員DC2
（研究実施機関：徳島大学実践栄養学分野）

2013年4月〜日本学術振興会特別研究員PD
（研究実施機関：徳島大学実践栄養学分野）

2014年 4月～
国立長寿医療研究センター老年学・社会科学研究センター NILS-LSA活用研究室（流動研究員）

2015年 4月～
徳島大学大学院医歯薬学研究部実践栄養学分野（助教）

2021年 1月～
徳島大学大学院医歯薬学研究部実践栄養学分野（講師）

登録日時

2018/11/19 11:45

更新日時

2024/4/17 20:32

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徳島大学

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学歴

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ＫＡＫＥＮで最新データを確認する

2024年4月27日更新

研究者番号: 40722533

所属（現在）: 2024/4/1 : 徳島大学, 大学院医歯薬学研究部(医学域), 講師

所属（過去の研究課題 情報に基づく）*注記: 2020/4/1 – 2022/4/1 : 徳島大学, 大学院医歯薬学研究部(医学域), 講師
2018/4/1 – 2019/4/1 : 徳島大学, 大学院医歯薬学研究部(医学域), 助教
2017/4/1 : 徳島大学, 大学院・医歯薬学研究部・栄養科学部門, 助教
2015/4/1 – 2017/4/1 : 徳島大学, 大学院医歯薬学研究部(医学系), 助教

審査区分/研究分野

研究代表者

総合系 / 複合領域 / 生活科学 / 食生活学
小区分38050:食品科学関連

研究代表者以外

生物系 / 医歯薬学 / 社会医学 / 衛生学・公衆衛生学
小区分59040:栄養学および健康科学関連

キーワード

研究代表者

大豆 / イソフラボン / 認知機能 / エストロゲン受容体 / 遺伝子多型 / 中高年者 / 長期縦断疫学研究 / 栄養疫学 / 知能 / 地域在住中高年者 / 縦断研究 / 豆類 / 海馬 / 嗅内野 / 脳 / 脳画像 / 大豆・イソフラボン / 地域住民 / エストロゲン受容体遺伝子

研究代表者以外

脂肪酸 / 認知機能 / 縦断研究 / インスリン抵抗性 / 炎症 / 中高年 / ポリメトキシフラボノイド / ノビレチン / スダチチン / Th17 / 自己免疫疾患 / マツダイダイン / ヘプタメトキシフラボン / EAE / 自己免疫性脳脊髄炎 / 抗原特異的免疫応答 / フラボノイド / 免疫機能 / 代謝機能 / メトキシ基

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中本真理子