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髙木康志

徳島大学

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2024年11月22日更新

職名: 教授
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学位: 医学博士 (京都大学) (1999年3月)
職歴・経歴: 2017/10: 徳島大学教授, 大学院医歯薬学研究部

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研究者総覧で最新データを確認する

2024年11月22日更新

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担当経験のある授業科目: 健康医療と最新技術の社会への活用 (共通教育)
情報統合医学実験実習・臨床研究実習 (大学院)
神経・精神・行動コース (学部)
脳と神経学概論 (大学院)
脳神経外科学 (大学院)
脳神経外科学(4年) (学部)
脳神経外科学演習 (大学院)
指導経験: 1人 (修士), 4人 (博士)

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2024年11月22日更新

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論文

Mai Azumi, Yoshifumi Mizobuchi, Nobuto Nakanishi, Kohhei Nakajima, Keijiro Hara, Toshitaka Fujihara, Manabu Ishihara, Jun Oto and Yasushi Takagi :
Value of the Acute Physiology and Chronic Health Evaluation II (APACHE II) score in predicting hospital mortality for postoperative brain tumor patients in intensive care units in Japan: A retrospective case-control study,
Clinical Neurology and Neurosurgery, Vol.244(2024), No.108435, 108435, 2024.

(要約): Acute Physiology and Chronic Health Evaluation II (APACHE II) is based on the data of intensive care unit (ICU) patients and often correlates with disease severity and prognosis. However, no prognostic predictors exist based on ICU admission data for patients with brain tumors, and no studies have reported an association between APACHE II and prognosis in patients with brain tumors. The Japanese Intensive Care Patients Database (JIPAD) was established to improve the quality of care delivered in intensive care medicine in Japan. We used JIPAD to examine factors associated with in-hospital mortality based on available data of postoperative patients with brain tumors admitted to the ICU. Patients aged ≥16 years enrolled in JIPAD between April 2015 and March 2018 after surgical brain tumor resection or biopsy of brain tumors. We examined factors related to outcomes at discharge based on blood tests and medical procedures performed during ICU admission, tumor type, and APACHE II score. Among the 1454 patients (male:female ratio: 1:1.1, mean age: 62 years) in the study, 32 (2.2 %) died during hospital stay. In multivariate analysis, male sex (odds ratio [OR] 2.70, [95 % confidence interval, CI 1.22-6.00]), malignant tumor (OR 2.51 [95 % CI 1.13-5.55]), and APACHE II score ≥15 (OR 2.51 [95 % CI 3.08-14.3]) were significantly associated with in-hospital mortality. By picking up cases with a high risk of in-hospital death at an early stage, it is possible to improve methods of treatment and support for the patient's family.
(キーワード): Humans / Male / Female / Middle Aged / Hospital Mortality / APACHE / Japan / Brain Neoplasms / Aged / Intensive Care Units / Retrospective Studies / Case-Control Studies / Adult / Prognosis / Aged, 80 and over / Predictive Value of Tests
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.clineuro.2024.108435
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38996799; ● Summary page in Scopus @ Elsevier: 2-s2.0-85198060266

(DOI: 10.1016/j.clineuro.2024.108435, PubMed: 38996799, Elsevier: Scopus) Yasuhisa Kanematsu, Yuki Kanazawa, Kenji Shimada, Masaaki Korai, Takeshi Miyamoto, Shu Sogabe, Manabu Ishihara, Izumi Yamaguchi, Takeshi Oya, Nobuaki Yamamoto, Yuki Yamamoto, Miyoshi Mitsuharu, Masafumi Harada and Yasushi Takagi :
Characterization of carotid plaques using chemical exchange saturation transfer imaging,
Neuroradiology, Vol.66, No.9, 1617-1624, 2024.

(要約): The preoperative assessment of carotid plaques is necessary to render revascularization safe and effective. The aim of this study is to evaluate the usefulness of chemical exchange saturation transfer (CEST)-MRI, particularly amide proton transfer (APT) imaging as a preoperative carotid plaque diagnostic tool. We recorded the APT signal intensity on concentration maps of 34 patients scheduled for carotid endarterectomy. Plaques were categorized into group A (APT signal intensity ≥ 1.90 E-04; n = 12) and group B (APT signal intensity < 1.90 E-04; n = 22). Excised plaques were subjected to histopathological assessment and, using the classification promulgated by the American Heart Association, they were classified as intraplaque hemorrhage-positive [type VI-positive (tVI)] and -negative [no intraplaque hemorrhage (tVI)]. Of the 34 patients, 22 (64.7%) harbored tVI- and 12 (35.3%) had tVI plaques. The median APT signals were significantly higher in tVI- than tIVI patients (2.43 E-04 (IQR = 0.98-4.00 E-04) vs 0.54 E-04 (IQR = 0.14-1.09 E-04), p < .001). Histopathologically, the number of patients with tVI plaques was significantly greater in group A (100%, n = 12) than group B (45%, n = 22) (p < .01). The number of symptomatic patients or asymptomatic patients with worsening stenosis was also significantly greater in group A than group B (75% vs 36%, p < .01). In unstable plaques with intraplaque hemorrhage and in patients with symptoms or progressive stenosis, the ATP signals were significantly elevated. CEST-MRI studies has the potential for the preoperative assessment of the plaques' characteristics.
(キーワード): Humans / Male / Female / Aged / Carotid Stenosis / Magnetic Resonance Imaging / Middle Aged / Endarterectomy, Carotid / Plaque, Atherosclerotic / Sensitivity and Specificity / Image Interpretation, Computer-Assisted
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s00234-024-03401-3
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38866959; ● Search Scopus @ Elsevier (PMID): 38866959; ● Search Scopus @ Elsevier (DOI): 10.1007/s00234-024-03401-3

(DOI: 10.1007/s00234-024-03401-3, PubMed: 38866959) Shu Sogabe, HABOSHI Tatsuya, Izumi Yamaguchi, Masaaki Korai, Nobuaki Yamamoto, Kenji Shimada, Yasuhisa Kanematsu and Yasushi Takagi :
Experience of using coronary perfusion balloon catheter for acute middle cerebral artery occlusion,
Surgical Neurology International, Vol.14, No.365, 365, 2023.

(要約): We present the case of an individual with acute occlusion of the middle cerebral artery caused by atherosclerosis. The patient underwent angioplasty using a coronary perfusion balloon, which resulted in a favorable clinical outcome. A 66-year-old male patient presented with an acute onset of right hemiplegia and dysarthria. Magnetic resonance imaging revealed an occlusion of the left middle cerebral artery, and alteplase was administered, followed by a mechanical thrombectomy and intracranial balloon catheter angioplasty. Due to restenosis, a coronary perfusion balloon catheter was used for a 15-minute angioplasty procedure while maintaining the perfusion. This treatment approach led to the recanalization of the artery and favorable clinical outcomes. The coronary perfusion balloon may represent a viable therapeutic alternative for the management of refractory intracranial atherosclerotic large vessel occlusion.
(徳島大学機関リポジトリ): ● Metadata: 119408
(出版サイトへのリンク): ● Publication site (DOI): 10.25259/SNI_608_2023
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37941628; ● CiNii @ 国立情報学研究所 (CRID): 1050582385450083840; ● Search Scopus @ Elsevier (PMID): 37941628; ● Search Scopus @ Elsevier (DOI): 10.25259/SNI_608_2023

(徳島大学機関リポジトリ: 119408, DOI: 10.25259/SNI_608_2023, PubMed: 37941628, CiNii: 1050582385450083840) Yuki Yamamoto, Nobuaki Yamamoto, Tomohiro Matsuda, Kazutaka Kuroda, Izumi Yamaguchi, Shu Sogabe, Masaaki Korai, Kenji Shimada, Yasuhisa Kanematsu, Yasushi Takagi and Yuishin Izumi :
Stent retrieval for free-floating thrombus attached to carotid artery stenosis: A report of two cases.,
Surgical Neurology International, Vol.14, 274, 2023.

(要約): In cases of carotid artery stenosis with FFT, it is technically possible to retrieve a thrombus with a stent retriever. Although thrombus removal may help reduce the risk of ischemic complications in a series of urgent CAS procedures, there are concerns such as mechanical irritation to the carotid artery plaque, and its indications and alternative treatments should be carefully considered.
(徳島大学機関リポジトリ): ● Metadata: 119409
(出版サイトへのリンク): ● Publication site (DOI): 10.25259/SNI_513_2023
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37680937; ● Search Scopus @ Elsevier (PMID): 37680937; ● Search Scopus @ Elsevier (DOI): 10.25259/SNI_513_2023

(徳島大学機関リポジトリ: 119409, DOI: 10.25259/SNI_513_2023, PubMed: 37680937) Joji Fujikawa, Ryoma Morigaki, Kazuhisa Miyake, Taku Matsuda, Hiroshi Koyama, Teruo Oda, Nobuaki Yamamoto, Yuishin Izumi, Hideo Mure, Satoshi Goto and Yasushi Takagi :
Cranial geometry in patients with dystonia and Parkinson's disease.,
Scientific Reports, Vol.13, No.1, 2023.

(要約): Abnormal skull shape has been reported in brain disorders. However, no studies have investigated cranial geometry in neurodegenerative disorders. This study aimed to evaluate the cranial geometry of patients with dystonia or Parkinson's disease (PD). Cranial computed tomography images of 36 patients each with idiopathic dystonia (IDYS), PD, and chronic subdural hematoma (CSDH) were analyzed. Those with IDYS had a significantly higher occipital index (OI) than those with CSDH (p = 0.014). When cephalic index (CI) was divided into the normal and abnormal groups, there was a significant difference between those with IDYS and CSDH (p = 0.000, α = 0.017) and between PD and CSDH (p = 0.031, α = 0.033). The age of onset was significantly correlated with the CI of IDYS (τ = - 0.282, p = 0.016). The Burke-Fahn-Marsden Dystonia Rating Scale motor score (BFMDRS-M) showed a significant correlation with OI in IDYS (τ = 0.372, p = 0.002). The cranial geometry of patients with IDYS was significantly different from that of patients with CSDH. There was a significant correlation between age of onset and CI, as well as between BFMDRS-M and OI, suggesting that short heads in the growth phase and skull balance might be related to the genesis of dystonia and its effect on motor symptoms.
(キーワード): Humans / Dystonia / Parkinson Disease / Treatment Outcome / Deep Brain Stimulation / Dystonic Disorders / Skull / Hematoma, Subdural, Chronic / Globus Pallidus
(徳島大学機関リポジトリ): ● Metadata: 118394
(出版サイトへのリンク): ● Publication site (DOI): 10.1038/s41598-023-37833-3
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37420081; ● Search Scopus @ Elsevier (PMID): 37420081; ● Search Scopus @ Elsevier (DOI): 10.1038/s41598-023-37833-3

(徳島大学機関リポジトリ: 118394, DOI: 10.1038/s41598-023-37833-3, PubMed: 37420081) Hiroshi Kagusa, Yamaguchi Izumi, Shono Kenji, Mizobuchi Yoshifumi, Shikata Eiji, Taku Matsuda, Takeshi Miyamoto, Keijiro Hara, Kitazato T Keiko, Yoshihiro Uto, Kanematsu Yasuhisa and Yasushi Takagi :
Differences in amyloid-β and tau/p-tau deposition in blood-injected mouse brains using micro-syringe to mimic traumatic brain microhemorrhages,
Journal of Chemical Neuroanatomy, Vol.130, 102258, 2023.

(要約): Cerebral microbleeds (CMBs) due to traumatic brain injuries (TBI) have been shown to lead to cognitive decline and impairment. CMBs caused by TBI may be associated with pathophysiological mechanisms involving inflammation and the accumulation of amyloid-β (Aβ), tau, and phosphorylated tau (p-tau), contributing to cognitive abnormalities. However, their relationships remain unclear. To test our hypothesis that Aβ, tau, and p-tau are accumulated and regulated separately in mice with injuries imitating CMBs from TBI, we studied. Seven-week-old C57BL/6 male mice were injected with 15 μL of heparinized autologous blood or saline by micro-syringe into the front lobe. Expression profiles and regulation of Aβ, tau, and p-tau were assessed immunohistochemically over time. On day 7 after blood injection, Iba-1 and S100B cells in damaged cortex adjacent to the injection site were higher than saline injection group and non-injected sham. On days 3-14, Aβ deposition were gradually increased but normalized by day 28. In contrast, tau/p-tau deposition gradually increased during days 14-28 and dispersed along the corticomedullary junction adjacent to hem deposits, indicating different expression profiles from Aβ. Deposits of Aβ, but not tau/p-tau, were phagocytosed by CD163 macrophages increased by Gc-protein macrophage-activating factor during days 7-28, suggesting different mechanisms of deposition and regulation between Aβ and tau/p-tau. Deposition and regulation differ between Aβ and tau/p-tau in mice with injuries mimicking CMBs from TBI. Further clarification of relationships between the pathologies of cognitive impairment and their neurodegenerative consequences is needed.
(キーワード): Amyloid-β / Cognitive impairment / Tauopathy / Traumatic cerebral microbleed
(徳島大学機関リポジトリ): ● Metadata: 119582
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jchemneu.2023.102258
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36925083; ● Search Scopus @ Elsevier (PMID): 36925083; ● Search Scopus @ Elsevier (DOI): 10.1016/j.jchemneu.2023.102258

(徳島大学機関リポジトリ: 119582, DOI: 10.1016/j.jchemneu.2023.102258, PubMed: 36925083) Nobuaki Yamamoto, Kazutaka Kuroda, Yuki Yamamoto, Izumi Yamaguchi, Shu Sogabe, Kenji Shimada, Ryoma Morigaki, Yasuhisa Kanematsu, Yuishin Izumi and Yasushi Takagi :
Long-sheath Introducer-assisted Revascularization (L-SHARE) Technique for Treating Large-vessel Occlusion by a Giant Clot,
Internal Medicine, Vol.62, No.6, 909-913, 2023.

(要約): Revascularization for common carotid artery (CCA) occlusion might be difficult. We reported our strategy for revascularizing CCA occlusion by giant clots. A 94-year-old woman was transferred to our hospital because of right hemiparesis and aphasia. CCA occlusion and giant clots were detected on ultrasonography. We performed mechanical thrombectomy using a 9-Fr balloon-guiding catheter, stent retriever, and aspiration catheter through a 9-Fr long-sheath introducer [long-sheath introducer-assisted revascularization (L-SHARE) technique]. We successfully recanalized CCA occlusion using this method. The L-SHARE technique might be useful for recanalization of CCA occlusion.
(キーワード): mechanical thrombectomy / long-sheath introducer / giant clot / cerebral large-vessel occlusion
(徳島大学機関リポジトリ): ● Metadata: 118794
(出版サイトへのリンク): ● Publication site (DOI): 10.2169/internalmedicine.0089-22
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35945008; ● CiNii @ 国立情報学研究所 (CRID): 1390576900004177024; ● Search Scopus @ Elsevier (PMID): 35945008; ● Search Scopus @ Elsevier (DOI): 10.2169/internalmedicine.0089-22

(徳島大学機関リポジトリ: 118794, DOI: 10.2169/internalmedicine.0089-22, PubMed: 35945008, CiNii: 1390576900004177024) Manabu Ishihara, Yasuhisa Kanematsu, Nobuaki Yamamoto, Kenji Shimada, Takeshi Miyamoto, Izumi Yamaguchi, Shu Sogabe, Yuki Yamamoto, Jun Oto and Yasushi Takagi :
Prognostic factors for acute large vessel occlusion with NIHSS 5 or lower.,
The Journal of Medical Investigation : JMI, Vol.70, No.1.2, 22-27, 2023.

(要約): MCA occlusion is associated with poor prognosis, even with NIHSS score ??5, and d-IAS may provide a predictor. J. Med. Invest. 70 : 22-27, February, 2023.
(キーワード): Humans / Tissue Plasminogen Activator / Stroke / Prognosis / Retrospective Studies / Treatment Outcome
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.70.22
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37164724; ● Search Scopus @ Elsevier (PMID): 37164724; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.70.22

(DOI: 10.2152/jmi.70.22, PubMed: 37164724) Yuki Kanazawa, Tosiaki Miyati, Masafumi Harada, Mitsuharu Miyoshi, Yuki Matsumoto, Hiroaki Hayashi, Yasuhisa Kanematsu and Yasushi Takagi :
Evaluation of Biological Metabolic Activity within an Atherosclerotic Plaque using Chemical Exchange Saturation Transfer Imaging,
Proceedings of ISMRM, Vol.32, No.2982, 2023. Mayuka Seguchi, Yuki Kanazawa, Tosiaki Miyati, Masafumi Harada, Mitsuharu Miyoshi, Yuki Matsumoto, Hiroaki Hayashi, Yasuhisa Kanematsu and Yasushi Takagi :
Diffusion weighted-viscosity imaging for atherosclerotic plaques,
Proceedings of ISMRM, Vol.32, No.1519, 2023. 兼松康久, 山口泉, 石原学, 曽我部周, 宮本健志, 高麗雅章, 島田健司, 黒田一駿, 山本雄貴, 山本伸昭, 和泉唯信, 髙木康志 :
循環器病を防ぐために徳島県循環器病推進計画の中での急性期脳卒中診療の取り組み,
四国医学雑誌, Vol.78, No.5-6, 135-138, 2022年.

(要約): Cerebrovascular and cardiovascular disease are the main causes of death in Japan. The leading causes of the need for long-term care in Japan are also cerebrovascular and cardiovascular disease, which together account for more than one-fourth of the total. The Cerebrovascular and Cardiovascular Disease Control Act, of Japanese national law, was promulgated by a legislative act in 2018. On the basis of the Cerebrovascular and Cardiovascular Disease Control Act, the Ministry of Health, Labour and Welfare, Japan, published the Japanese National Plan for Promotion of Measures Against Cerebrovascular and Cardiovascular Disease (Japanese National Plan) in 2020. By the example of the Japanese National Plan, Tokushima prefecture established a cerebrovascular and cardiovascular disease countermeasure promotion plan to progress cerebrovascular and cardiovascular disease measures according to their own circumstances. One of the important measures of the plan is improving emergency transportation systems. Patients with intracranial large vessel occlusion strokes should be served by direct transfer to endovascular capable centers avoiding delays by misguided transfer to primary stroke centers. Considering the limited availability of endovascular capable centers, accurate identification of patients with high probability of having large vessel occlusion strokes in the prehospital setting is importance. To address this problem, we introduced prehospital scale called Field Assessment Stroke Triage for Emergency Destination (FAST-ED) on emergency transportation systems in Tokushima city.
(キーワード): Cerebrovascular and cardiovascular disease / emergency transportation systems / prehospital scale
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1050295181679880704

(CiNii: 1050295181679880704) Yoshitaka Kurashiki, Hiroshi Kagusa, Kenji Yagi, Tomoya Kinouchi, Manabu Sumiyoshi, Takeshi Miyamoto, Kenji Shimada, Keiko T Kitazato, Yoshihiro Uto and Yasushi Takagi :
Role of post-ischemic phase-dependent modulation of anti-inflammatory M2-type macrophages against rat brain damage,
Journal of Cerebral Blood Flow and Metabolism, 2022.

(要約): Cerebral ischemia triggers inflammatory changes, and early complications and unfavorable outcomes of endovascular thrombectomy for brain occlusion promote the recruitment of various cell types to the ischemic area. Although anti-inflammatory M2-type macrophages are thought to exert protective effects against cerebral ischemia, little has been clarified regarding the significance of post-ischemic phase-dependent modulation of M2-type macrophages. To test our hypothesis that post-ischemic phase-dependent modulation of macrophages represents a potential therapy against ischemic brain damage, the effects on rats of an M2-type macrophage-specific activator, Gc-protein macrophage-activating factor (GcMAF), were compared with vehicle-treated control rats in the acute (day 0-6) or subacute (day 7-13) phase after ischemia induction. Acute-phase GcMAF treatment augmented both anti-inflammatory CD163 M2-type- and pro-inflammatory CD16 M1-type macrophages, resulting in no beneficial effects. Conversely, subacute-phase GcMAF injection increased only CD163 M2-type macrophages accompanied by elevated mRNA levels of arginase-1 and interleukin-4. M2-type macrophages co-localized with CD36 phagocytic cells led to clearance of the infarct area, which were abrogated by clodronate-liposomes. Expression of survival-related molecules on day 28 at the infarct border was augmented by GcMAF. These data provide new and important insights into the significance of M2-type macrophage-specific activation as post-ischemic phase-dependent therapy.
(徳島大学機関リポジトリ): ● Metadata: 118878
(出版サイトへのリンク): ● Publication site (DOI): 10.1177/0271678X221147090
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36545833; ● Summary page in Scopus @ Elsevier: 2-s2.0-85145451559

(徳島大学機関リポジトリ: 118878, DOI: 10.1177/0271678X221147090, PubMed: 36545833, Elsevier: Scopus) 黒田一駿, 山本雄貴, 山本伸昭, 和泉唯信, 山口泉, 島田健司, 兼松康久, 宮本健志, 髙木康志 :
脳静脈洞血栓症に対して経皮的血栓回収術を行った3例,
四国医学雑誌, Vol.78, No.5-6, 221-226, 2022年. 山本雄貴, 山本伸昭, 黒田一駿, 和泉唯信, 兼松康久, 山口泉, 曽我部周, 高麗雅章, 島田健司, 髙木康志 :
徳島市におけるアプリケーションを用いた脳主幹動脈閉塞診断スケールの活用,,
四国医学雑誌, Vol.78, No.5,6, 248-249, 2022年. Taku Matsuda, Ryoma Morigaki, Yuki Matsumoto, Hideo Mure, Kazuhisa Miyake, Masahito Nakataki, Masafumi Harada and Yasushi Takagi :
Obsessivecompulsive symptoms are negatively correlated with motor severity in patients with generalized dystonia,
Scientific Reports, Vol.12, No.1, 20350, 2022.

(要約): We aimed to clarify the correlations between motor symptoms and obsessive-compulsive symptoms and between the volumes of basal ganglia components and obsessive-compulsive symptoms. We retrospectively included 14 patients with medically intractable, moderate and severe generalized dystonia. The Burke-Fahn-Marsden Dystonia Rating Scale and Maudsley Obsessional Compulsive Inventory were used to evaluate the severity of dystonia and obsessive-compulsive symptoms, respectively. Patients with generalized dystonia were divided into two groups; patients whose Maudsley Obsessional Compulsive Inventory score was lower than 13 (Group 1) and 13 or more (Group 2). Additionally, the total Maudsley Obsessional Compulsive Inventory scores in patients with dystonia were significantly higher than normal volunteers' scores (p = 0.025). Unexpectedly, Group 2 (high Maudsley Obsessional Compulsive Inventory scores) showed milder motor symptoms than Group 1 (low Maudsley Obsessional Compulsive Inventory scores) (p = 0.016). "Checking" rituals had a strong and significant negative correlation with the Burke-Fahn-Marsden Dystonia Rating Scale (ϱ = - 0.71, p = 0.024) and a strong positive correlation with the volumes of both sides of the nucleus accumbens (right: ϱ = 0.72, p = 0.023; left: ϱ = 0.70, p = 0.034). Our results may provide insights into the pathogenesis of obsessive-compulsive disorder and dystonia.
(キーワード): Humans / Dystonia / Retrospective Studies / Dystonic Disorders / Heredodegenerative Disorders, Nervous System
(出版サイトへのリンク): ● Publication site (DOI): 10.1038/s41598-022-24826-x
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36437372; ● Search Scopus @ Elsevier (PMID): 36437372; ● Search Scopus @ Elsevier (DOI): 10.1038/s41598-022-24826-x

(DOI: 10.1038/s41598-022-24826-x, PubMed: 36437372) Kenji Shimada, Kazuhisa Miyake, Izumi Yamaguchi, Shu Sogabe, Masaaki Korai, Yasuhisa Kanematsu and Yasushi Takagi :
Efficacy of Utilizing Both 3-Dimensional Multimodal Fusion Image and Intra-Arterial Indocyanine Green Videoangiography in Cerebral Arteriovenous Malformation Surgery,
World Neurosurgery, Vol.169, e260-e269, 2022.

(要約): An understanding of the complex morphology of an arteriovenous malformation (AVM) is important for successful resection. We have previously reported the utility of intra-arterial indocyanine green (ICG) videoangiography for this purpose, but that method cannot detect the angioarchitecture covered by brain tissue. 3-dimensional (3D) multimodal fusion imaging is reportedly useful for this same purpose, but cannot always visualize the exact angioarchitecture due to poor source images and processing techniques. This study examined the results of utilizing both techniques in patients with AVMs. Both techniques were applied in 12 patients with AVMs. Both images were compared with surgical views and evaluated by surgeons. Although evaluations for identifying superficial feeders by ICG videoangiography were high in all cases, the more complicated the AVM, the lower the evaluation by 3D multimodal fusion imaging. Conversely, evaluation of the estimated range of the nidus was high in all cases by 3D multimodal fusion imaging, but low in all but one case by ICG videoangiography. Nidus flow reduction was recognized by Flow 800 analysis obtained after ICG videoangiography. These results showed that utilizing both techniques together was more useful than each modality alone in AVM surgery. This was particularly effective in identifying superficial feeders and estimating the range of the nidus. This technique is expected to offer an optimal tool for AVM surgery.
(徳島大学機関リポジトリ): ● Metadata: 118079
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.wneu.2022.10.121
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36332776; ● Search Scopus @ Elsevier (PMID): 36332776; ● Search Scopus @ Elsevier (DOI): 10.1016/j.wneu.2022.10.121

(徳島大学機関リポジトリ: 118079, DOI: 10.1016/j.wneu.2022.10.121, PubMed: 36332776) Masaaki Korai, Noriya Enomoto, Koichi Satoh, Shunji Matsubara, Yasuhisa Kanematsu, Tadashi Yamaguchi, Mami Hanaoka, Hitoshi Niki, Kazuhito Matsuzaki, Koji Bando, Hirotaka Hagino and Yasushi Takagi :
Transarterial embolization for convexity dural arteriovenous fistula with or without pial arterial supply: A report of four patients,
Surgical Neurology International, Vol.13, No.340, 1-6, 2022.

(徳島大学機関リポジトリ): ● Metadata: 117905
(出版サイトへのリンク): ● Publication site (DOI): 10.25259/SNI_215_2022
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.25259/SNI_215_2022

(徳島大学機関リポジトリ: 117905, DOI: 10.25259/SNI_215_2022) J Fujikawa, Ryoma Morigaki, Nobuaki Yamamoto, H Nakanishi, T Oda, Yuishin Izumi and Yasushi Takagi :
Diagnosis and Treatment of Tremor in Parkinson's Disease Using Mechanical Devices,
Life, Vol.13, No.1, 78, 2022.

(要約): Parkinsonian tremors are sometimes confused with essential tremors or other conditions. Recently, researchers conducted several studies on tremor evaluation using wearable sensors and devices, which may support accurate diagnosis. Mechanical devices are also commonly used to treat tremors and have been actively researched and developed. Here, we aimed to review recent progress and the efficacy of the devices related to Parkinsonian tremors. The PubMed and Scopus databases were searched for articles. We searched for "Parkinson disease" and "tremor" and "device". Eighty-six articles were selected by our systematic approach. Many studies demonstrated that the diagnosis and evaluation of tremors in patients with PD can be done accurately by machine learning algorithms. Mechanical devices for tremor suppression include deep brain stimulation (DBS), electrical muscle stimulation, and orthosis. In recent years, adaptive DBS and optimization of stimulation parameters have been studied to further improve treatment efficacy. Due to developments using state-of-the-art techniques, effectiveness in diagnosing and evaluating tremor and suppressing it using these devices is satisfactorily high in many studies. However, other than DBS, no devices are in practical use. To acquire high-level evidence, large-scale studies and randomized controlled trials are needed for these devices.
(徳島大学機関リポジトリ): ● Metadata: 118913
(出版サイトへのリンク): ● Publication site (DOI): 10.3390/life13010078
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36676025; ● Search Scopus @ Elsevier (PMID): 36676025; ● Search Scopus @ Elsevier (DOI): 10.3390/life13010078

(徳島大学機関リポジトリ: 118913, DOI: 10.3390/life13010078, PubMed: 36676025) Eiji Shikata, Takeshi Miyamoto, Tadashi Yamaguchi, Izumi Yamaguchi, Hiroshi Kagusa, Daiki Gotoh, Kenji Shimada, Yoshiteru Tada, Kenji Yagi, 北里慶子, Yasuhisa Kanematsu and Yasushi Takagi :
An imbalance between RAGE/MR/HMGB1 and ATP1α3 is associated with infammatory changes in rat brain harboring cerebral aneurysms prone to rupture,
Journal of Neuroinflammation, Vol.19, No.161, 161, 2022.

(要約): An aneurysmal subarachnoid hemorrhage is a devastating event. To establish an effective therapeutic strategy, its pathogenesis must be clarified, particularly the pathophysiology of brain harboring intracranial aneurysms (IAs). To elucidate the pathology in brain harboring IAs, we examined the significance of the receptor for advanced glycation end-products (RAGE)/mineralocorticoid receptor (MR) pathway and Na/K-ATPase (ATP1α3). Ten-week-old female rats were subjected to oophorectomy as well as hypertension and hemodynamic changes to induce IAs, and were fed a high-salt diet. Brain damage in these rats was assessed by inflammatory changes in comparison to sham-operated rats fed a standard diet. Six weeks after IA induction (n = 30), irregular morphological changes, i.e., an enlarged vessel diameter and vascular wall, were observed in all of the left posterior cerebral arteries (Lt PCAs) prone to rupture. Approximately 20% of rats had ruptured IAs within 6 weeks. In brain harboring unruptured IAs at the PCA, the mRNA levels of RAGE and MR were higher, and that of ATP1α3 was lower than those in the sham-operated rats (p < 0.05, each). Immunohistochemically, elevated expression of RAGE and MR, and decreased expression of ATP1α3 were observed in the brain parenchyma adjacent to the Lt PCA, resulting in increased Iba-1 and S100B expression that reflected the inflammatory changes. There was no difference between the unruptured and ruptured aneurysm rat groups. Treatment with the MR antagonist esaxerenone abrogated these changes, and led to cerebral and vascular normalization and prolonged subarachnoid hemorrhage-free survival (p < 0.05). Regulation of the imbalance between the RAGE/MR pathway and ATP1α3 may help attenuate the damage in brain harboring IAs, and further studies are warranted to clarify the significance of the down-regulation of the MR/RAGE pathway and the up-regulation of ATP1α3 for attenuating the pathological changes in brain harboring IAs.
(キーワード): Aneurysm, Ruptured / Animals / Brain / Female / HMGB1 Protein / Intracranial Aneurysm / Rats / Receptor for Advanced Glycation End Products / Receptors, Mineralocorticoid / Sodium-Potassium-Exchanging ATPase / Subarachnoid Hemorrhage
(徳島大学機関リポジトリ): ● Metadata: 117703
(出版サイトへのリンク): ● Publication site (DOI): 10.1186/s12974-022-02526-7
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35725479; ● Search Scopus @ Elsevier (PMID): 35725479; ● Search Scopus @ Elsevier (DOI): 10.1186/s12974-022-02526-7

(徳島大学機関リポジトリ: 117703, DOI: 10.1186/s12974-022-02526-7, PubMed: 35725479) Kenji Shimada, Izumi Yamaguchi, Takeshi Miyamoto, Shu Sogabe, Kazuhisa Miyake, Yasuhisa Kanematsu and Yasushi Takagi :
Efficacy of intraarterial indocyanine green videoangiography in surgery for arteriovenous fistula at the craniocervical junction in a hybrid operating room: illustrative cases,
Journal of Neurosurgery. Case Lessons, Vol.3, No.23, 1-6, 2022.

(要約): Sufficient understanding of the angioarchitecture of an arteriovenous fistula (AVF) at the craniocervical junction (CCJ) is crucial to surgical treatment but is often difficult because of the complex vascular anatomy. Intraarterial indocyanine green (ICG) videoangiography has emerged as a more useful option for understanding the vascular anatomy than intravenous ICG videoangiography. This report describes two cases of CCJ AVFs successfully treated by surgery using intraarterial ICG videoangiography and describes the efficacy of this technique. Case 1 involved a 71-year-old man presenting with tetraparesis after sudden onset of severe headache due to subarachnoid hemorrhage (SAH). Digital subtraction angiography (DSA) demonstrated CCJ epidural AVF. Intraarterial ICG videoangiography revealed the drainer, which had been difficult to identify. The AVF disappeared after disconnection of the drainer. Case 2 involved a 68-year-old man presenting with severe headache due to SAH. DSA showed multiple AVFs at the CCJ and cerebellar tentorium. Intraarterial ICG videoangiography demonstrated concomitant perimedullary AVF and dural AVF at the CCJ. All AVFs disappeared postoperatively. Intraarterial ICG videoangiography was useful for definitive diagnosis of CCJ AVF, facilitating identification of feeders and drainers with bright and high phase contrast and allowing repeated testing to confirm flow direction.
(出版サイトへのリンク): ● Publication site (DOI): 10.3171/CASE22100
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35733826; ● Search Scopus @ Elsevier (PMID): 35733826; ● Search Scopus @ Elsevier (DOI): 10.3171/CASE22100

(DOI: 10.3171/CASE22100, PubMed: 35733826) Izumi Yamaguchi, Yasuhisa Kanematsu, Kenji Shimada, Nobuaki Yamamoto, Kazuhisa Miyake, Takeshi Miyamoto, Shu Sogabe, Eiji Shikata, Manabu Ishihara, 山本陽子, Kazutaka Kuroda and Yasushi Takagi :
Single-session hematoma removal and transcortical venous approach for coil embolization of an isolated transverse-sigmoid sinus dural arteriovenous fistula in a hybrid operating room: illustrative case,
Journal of Neurosurgery. Case Lessons, Vol.3, No.21, CASE2267, 2022.

(要約): Dural arteriovenous fistula (DAVF) can present with massive hematoma, which sometimes requires emergent removal. Therefore, a surgical strategy for single-session hematoma removal and shunt occlusion in the same surgical field is important. A 73-year-old man was transferred to the authors' hospital with a headache. Brain computed tomography (CT) revealed an intracerebral hematoma in the right temporoparietal lobe (hematoma volume 12 ml). A cerebral angiogram revealed a right isolated transverse-sigmoid sinus (TSS)-DAVF fed by the occipital artery and middle meningeal artery. There was cortical venous reflux into the Labbé vein and posterior parietal vein. Percutaneous transarterial and transvenous embolization were unsuccessful. The following day, his consciousness level acutely declined with a headache, and brain CT showed hematoma expansion (hematoma volume 41 ml) with a midline shift. Therefore, the authors performed single-session hematoma removal and a transcortical venous approach for coil embolization of an isolated TSS-DAVF in a hybrid operating room. His postoperative course was uneventful. No recurrence was observed 3 months postoperatively on cerebral angiography. Single-session hematoma removal and a transcortical venous approach for coil embolization of an isolated TSS-DAVF is considered in cases with massive hematoma. This strategy is useful, considering recent developments in hybrid operating rooms.
(出版サイトへのリンク): ● Publication site (DOI): 10.3171/CASE2267
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35734231; ● Summary page in Scopus @ Elsevier: 2-s2.0-85160834258

(DOI: 10.3171/CASE2267, PubMed: 35734231, Elsevier: Scopus) Tadashi Yamaguchi, Takeshi Miyamoto, Eiji Shikata, Izumi Yamaguchi, Kenji Shimada, Kenji Yagi, Yoshiteru Tada, Masaaki Korai, Keiko T. Kitazato, Yasuhisa Kanematsu and Yasushi Takagi :
Activation of the NLRP3/IL-1β/MMP-9 pathway and intracranial aneurysm rupture associated with the depletion of ERα and Sirt1 in oophorectomized rats,
Journal of Neurosurgery, 1-8, 2022.

(要約): Subarachnoid hemorrhage (SAH) due to intracranial aneurysm (IA) rupture is often a devastating event. Since the incidence of SAH increases especially in menopause, it is crucial to clarify the detailed pathogenesis of these events. The activation of vascular nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasomes has been studied in ischemic stroke and cardiovascular disease. However, the role of NLRP3 in IA rupture still needs to be explained. The authors sought to test their hypothesis that, under estrogen-deficient conditions, activation of NLRP3 inflammasomes via downregulation of the estrogen receptor (ER) facilitates IA rupture. Ten-week-old female Sprague Dawley rats with and without oophorectomy were subjected to hemodynamic changes and hypertension (OVX+/HT and OVX-/HT, respectively) and fed a high-salt diet. Separately, using human brain endothelial cells (HBECs) and human brain smooth muscle cells (HBSMCs), the authors tested the effect of NLRP3 under estrogen-free conditions and in the presence of estradiol or of ER agonists. In OVX+/HT rats, the frequency of IA rupture was significantly higher than in OVX-/HT rats (p = 0.03). In the left posterior cerebral artery prone to rupture in OVX+/HT rats, the levels of the mRNAs encoding ERα and Sirt1, but not of that encoding ERβ, were decreased, and the levels of the mRNAs encoding NLRP3, interleukin-1β (IL-1β), and matrix metalloproteinase 9 (MMP-9) were elevated. Immunohistochemical analysis demonstrated that the expression profiles of these proteins correlated with their mRNA levels. Treatment with an ER modulator, bazedoxifene, normalized the expression profiles of these proteins and improved SAH-free survival. In HBECs and HBSMCs under estrogen-free conditions, the depletion of ERα and Sirt1 and the accumulation of NLRP3 were counteracted by exposure to estradiol or to an ERα agonist but not to an ERβ agonist. To the authors' knowledge, this work represents the first demonstration that, in an aneurysm model under estrogen-deficient conditions, the depletion of ERα and Sirt1 may contribute to activation of the NLRP3/IL-1β/MMP-9 pathway, facilitating the rupture of IAs in the estrogen-deficient rat IA rupture model.
(徳島大学機関リポジトリ): ● Metadata: 117700
(出版サイトへのリンク): ● Publication site (DOI): 10.3171/2022.4.JNS212945
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35594890; ● Search Scopus @ Elsevier (PMID): 35594890; ● Search Scopus @ Elsevier (DOI): 10.3171/2022.4.JNS212945

(徳島大学機関リポジトリ: 117700, DOI: 10.3171/2022.4.JNS212945, PubMed: 35594890) Shinji Nagahiro, Yoshifumi Mizobuchi, Kohhei Nakajima and Yasushi Takagi :
A Novel Approach to Microvascular Decompression for Hemifacial Spasm: Method Description and Associated Outcome,
Operative Neurosurgery, Vol.00, 1-7, 2022.

(要約): Microvascular decompression (MVD) is the only potential cure for hemifacial spasm (HFS). However, traditional techniques such as the interposition method may have limited effect in some cases. Alternative techniques have been proposed; however, they can be more complex or difficult to perform than the standard approach. To describe a safe decompression technique-the "shelter method"-which involves creating a shelter-like space around the facial nerve root exit zone and present associated outcomes. Medical records and intraoperative findings of 92 patients with HFS who underwent MVD using the shelter method between April 1997 and March 2017 were retrospectively reviewed. As a historical control group, we included 53 patients who had undergone MVD by the traditional interposition method before March 1989. The patients were divided into 3 subgroups according to the arteries involved and degree or direction of arterial compression to the seventh nerve. Patient outcomes were assessed as excellent, good, fair, and poor according to the MVD scoring system of the Japan Society for MVD Surgery. In the shelter method group, complete disappearance of HFS was achieved in 87 patients (94.6%). The curative rate of the shelter method group was significantly higher than that of the interposition method group. The overall complication rates were significantly lower in the shelter method group than in the interposition method group. Our findings indicate high curative and low complication rates of the shelter method, suggesting that it helps treat HFS caused by various types of arterial compression.
(キーワード): Facial Nerve / Hemifacial Spasm / Humans / Microvascular Decompression Surgery / Retrospective Studies / Treatment Outcome
(出版サイトへのリンク): ● Publication site (DOI): 10.1227/ons.0000000000000223
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35486878; ● Search Scopus @ Elsevier (PMID): 35486878; ● Search Scopus @ Elsevier (DOI): 10.1227/ons.0000000000000223

(DOI: 10.1227/ons.0000000000000223, PubMed: 35486878) Eiji Shikata, Izumi Yamaguchi, Masaaki Korai, Takeshi Miyamoto, Tadashi Yamaguchi, Hiroshi Kagusa, Kenji Shimada, Yoshiteru Tada, Keiko Kitazato, Yasuhisa Kanematsu and Yasushi Takagi :
Could clazosentan, first approved in Japan, improve neurological prognosis after subarachnoid hemorrhage in combination with modified water-electrolyte management?,
Brain Hemorrhages, Vol.137, No.6, 1707-1717, 2022.

(徳島大学機関リポジトリ): ● Metadata: 118951
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.hest.2023.10.005
(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-85175417356

(徳島大学機関リポジトリ: 118951, DOI: 10.1016/j.hest.2023.10.005, Elsevier: Scopus) Joji Fujikawa, Ryoma Morigaki, Nobuaki Yamamoto, Teruo Oda, Hiroshi Nakanishi, Yuishin Izumi and Yasushi Takagi :
Therapeutic Devices for Motor Symptoms in Parkinson's Disease: Current Progress and a Systematic Review of Recent Randomized Controlled Trials.,
Frontiers in Aging Neuroscience, Vol.14, 2022.

(要約): Invasive and non-invasive medical devices have unique characteristics, and several RCTs have been conducted for each device. Invasive devices are more effective, while non-invasive devices are less effective and have lower hurdles and risks. It is important to understand the characteristics of each device and capitalize on these.
(徳島大学機関リポジトリ): ● Metadata: 117340
(出版サイトへのリンク): ● Publication site (DOI): 10.3389/fnagi.2022.807909
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35462692; ● Search Scopus @ Elsevier (PMID): 35462692; ● Search Scopus @ Elsevier (DOI): 10.3389/fnagi.2022.807909

(徳島大学機関リポジトリ: 117340, DOI: 10.3389/fnagi.2022.807909, PubMed: 35462692) Yoshiteru Tada, Toshitaka Fujihara, Kenji Shimada, Nobuaki Yamamoto, Hiroki Yamazaki, Yuishin Izumi, Masafumi Harada, Yasuhisa Kanematsu and Yasushi Takagi :
Seizure types associated with negative arterial spin labeling and positive diffusion-weighted imaging on peri-ictal magnetic resonance imaging,
Journal of the Neurological Sciences, Vol.436, 1-8, 2022.

(要約): Arterial spin labeling (ASL) and diffusion-weighted imaging (DWI) are useful for assessing hyperperfusion and cytotoxic edema, respectively, caused by acute seizures. This study investigated the clinical characteristics associated with normal ASL findings and DWI abnormalities in patients with acute seizures. Overall, 41 patients with ASL and DWI images that were obtained within 48 h of focal onset seizure diagnosis, due to epilepsy or acute symptomatic seizures, were divided into groups based on initial ASL findings (ASL-negative vs. ASL-positive), and DWI abnormalities (DWI-negative vs. DWI-positive). The diagnosis was made based on seizure semiology, electroencephalography, and conventional imaging modalities. ASL and DWI abnormalities were based on visual assessment. Of the 41 patients, eight (19.5%) displayed normal ASL findings. The proportion of patients with focal aware seizures (FAS) was significantly higher among ASL-negative patients (62.5%) than that in ASL-positive patients (15.2%); the proportion of patients with focal impaired awareness seizures (FIAS) was significantly lower among ASL-negative patients (12.5%) than that among ASL-positive patients (57.6%). Hyperintensity findings on DWI were observed in 12 patients (29.3%, DWI-positive). The proportion of patients with FIAS was significantly higher among DWI-positive patients (75.0%) than that among DWI-negative patients (37.9%). Multivariate analysis revealed that FAS and FIAS were associated with normal ASL findings (odds ratio [OR]: 21.37, P = 0.010) and DWI abnormalities (OR = 6.11, P = 0.028). A diagnosis of seizures should not be excluded based on normal ASL findings, especially in patients with FAS. FIAS may be a risk factor for neuronal damage caused by seizure activity.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jns.2022.120223
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35279594; ● Summary page in Scopus @ Elsevier: 2-s2.0-85126008460

(DOI: 10.1016/j.jns.2022.120223, PubMed: 35279594, Elsevier: Scopus) Yuki Yamamoto, Nobuaki Yamamoto, Yasuhisa Kanematsu, Izumi Yamaguchi, Manabu Ishihara, Takeshi Miyamoto, Shu Sogabe, Kenji Shimada, Yasushi Takagi and Yuishin Izumi :
The claw sign predicts first-pass effect in mechanical thrombectomy for cerebral large vessel occlusion in the anterior circulation,
Surgical Neurology International, Vol.13, No.72, 1-7, 2022.

(要約): Mechanical thrombectomy (MT) is an effective treatment for acute cerebral large vessel occlusion (LVO). Complete recanalization of vessels in a single procedure is defined as the first-pass effect (FPE) and is associated with good prognosis. In this study, angiographic clot protruding sign termed the "claw sign," was examined as candidate preoperative imaging factor for predicting the FPE. We retrospectively analyzed data from 91 consecutive patients treated for acute LVO in the anterior circulation by MT between January 2014 and December 2019. The claw sign was defined as a thrombus that protruded proximally by more than half of the diameter of the parent artery. Radiological findings such as claw sign, clinical and etiological features, and outcomes were compared between groups with and without successful FPE. Multivariate analysis was conducted to evaluate perioperative factors associated with FPE. FPE was achieved in 26 of 91 (28.6%) patients and the claw sign was observed in 34 of 91 (37.4%) patients. The claw sign was significantly more frequent in the successful FPE group than in the failed FPE group (53.8% vs. 30.8%; = 0.040). After the multivariate analysis, the claw sign was the only pretreatment parameter that could predict FPE (odds ratio, 2.67; 95% confidence interval, 1.01-7.06; = 0.047). The claw sign is an angiographic imaging factor that might predict FPE after MT for anterior circulation acute ischemic stroke.
(徳島大学機関リポジトリ): ● Metadata: 117192
(出版サイトへのリンク): ● Publication site (DOI): 10.25259/SNI_1160_2021
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35242438; ● Search Scopus @ Elsevier (PMID): 35242438; ● Search Scopus @ Elsevier (DOI): 10.25259/SNI_1160_2021

(徳島大学機関リポジトリ: 117192, DOI: 10.25259/SNI_1160_2021, PubMed: 35242438) Yoshifumi Mizobuchi, Kohhei Nakajima, Toshitaka Fujihara, Mai Azumi and Yasushi Takagi :
Development of a Navigation-guided Fence-post Catheter for Brain Tumor Resection,
The Journal of Medical Investigation : JMI, Vol.69, No.1,2, 117-119, 2022.

(要約): Navigation system devices have been developed to allow precise resection of brain tumor. The fence-post catheter techniques that use a navigation system have been used in many neurosurgery centers. However, an exclusive catheter for the fence-post catheter techniques have not been made, and substituted silicon tube of the cerebral ventricle drainage or a Nelaton catheter is widely used. In this brief technical note, we describe a new fence-post catheter with steel tip device that was designed for more precise tissue resection and is useful in tumor resection. The newly designed fence-post catheter helps to visually gauge the accurate depth from the tumor bottom during tumor resection. Furthermore, the catheter tip has moderate weight and is made of a non-magnetic material. Using our fence-post catheter, which has a metal part at the tip of the tube (length, 13 mm), operators can clearly notice that they are getting closer to base of the tumor by checking the metal part during the resection of deep tumors. Our newly developed fence-post tube enables easy confirmation of the distance to deep-tissue regions and improves the degree of safety during tumor removal. J. Med. Invest. 69 : 117-119, February, 2022.
(キーワード): Brain / Brain Neoplasms / Catheters / Glioma / Humans / Neurosurgical Procedures
(徳島大学機関リポジトリ): ● Metadata: 117022
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.69.117
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35466132; ● Summary page in Scopus @ Elsevier: 2-s2.0-85128801353

(徳島大学機関リポジトリ: 117022, DOI: 10.2152/jmi.69.117, PubMed: 35466132, Elsevier: Scopus) Izumi Yamaguchi, Yasuhisa Kanematsu, Yoshifumi Mizobuchi, Yoshiteru Tada, Takeshi Miyamoto, Shu Sogabe, Manabu Ishihara, Hiroshi Kagusa, Yoko Yamamoto, Taku Matsuda, Keiko T. Kitazato, Yoshihiro Okayama and Yasushi Takagi :
Chronic subdural hematoma associated with dural metastasis leads to early recurrence and death: A single-institute, retrospective cohort study,
Journal of Clinical Neuroscience, Vol.94, 244-249, 2021.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jocn.2021.10.037
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1016/j.jocn.2021.10.037

(DOI: 10.1016/j.jocn.2021.10.037) Kenya Kusunose, Hironori Takahashi, Susumu Nishio, Yukina Hirata, Robert Zheng, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Kenji Shimada, Yasuhisa Kanematsu, Yasushi Takagi and Masataka Sata :
Predictive value of left atrial function for latent paroxysmal atrial fibrillation as the cause of embolic stroke of undetermined source,
Journal of Cardiology, Vol.78, No.5, 355-361, 2021.

(要約): In patients with embolic stroke of undetermined source (ESUS), paroxysmal atrial fibrillation (AF) is often diagnosed, however, the risk of paroxysmal AF in ESUS has not been well described. Several studies have suggested a linkage between left atrial (LA) functional parameters and risk of AF in stroke patients. The aim of this study was to assess the role of LA functional parameters as predictors of latent paroxysmal AF in ESUS on admission. Between January 2015 and December 2019, consecutive stroke patients with suspected ESUS at admission were prospectively included in this study. They were under hospital electrocardiographic monitoring for detection of new-onset AF. Various echocardiographic parameters including left atrial strain were assessed for association with new-onset AF. We gathered 1082 consecutive patients with ischemic stroke. After exclusions, 121 patients with suspected ESUS at admission formed the study cohort. New-onset AF was detected in 46 (38%) patients during hospital electrocardiographic monitoring (median follow-up: 18 days). LA pump and reservoir strains were significantly and independently associated with new-onset AF. Receiver operating characteristic analysis for the association with new-onset AF showed that the areas under the curve (AUCs) of clinical parameters plus one of each strain (LA pump strain: AUC: 0.86±0.04 and LA reservoir strain: AUC: 0.76±0.05) models were significantly better than plus LA volume index (AUC: 0.68±0.04, compared p-values <0.05). LA strain was significantly associated with new development of AF. Patients with impaired LA function at admission should be carefully monitored to find AF.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jjcc.2021.05.005
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34119401; ● Search Scopus @ Elsevier (PMID): 34119401; ● Search Scopus @ Elsevier (DOI): 10.1016/j.jjcc.2021.05.005

(DOI: 10.1016/j.jjcc.2021.05.005, PubMed: 34119401) Kenji Shimada, Izumi Yamaguchi, Manabu Ishihara, Takeshi Miyamoto, Shu Sogabe, Kazuhisa Miyake, Yoshiteru Tada, 北里慶子, Yasuhisa Kanematsu and Yasushi Takagi :
Involvement of Neutrophil Extracellular Traps in Cerebral Arteriovenous Malformations,
World Neurosurgery, E1-E7, 2021.

(要約): Cerebral arteriovenous malformations (cAVMs) represent tangles of abnormal vasculature without intervening capillaries. High-pressure vascular channels due to abnormal arterial and venous shunts can lead to rupture. Multiple pathways are involved in the pathobiology of cAVMs including inflammation and genetic factors such as KRAS mutations. Neutrophil release of nuclear chromatin, known as neutrophil extracellular traps (NETs), plays a multifunctional role in infection, inflammation, thrombosis, intracranial aneurysms, and tumor progression. However, the relationship between NETs and the pathobiology of cAVMs remains unknown. We tested whether NETs play a role in the pathobiology of cAVMs. We analyzed samples from patients who had undergone surgery for cAVM and immunohistochemically investigated expression of citrullinated histone H3 (CitH3) as a marker of NETs. CitH3 expression was compared among samples from cAVM patients, epilepsy patients, and normal human brain tissue. Expressions of thrombotic and inflammatory markers were also examined immunohistochemically in samples from cAVM patients. Expression of CitH3 derived from neutrophils was observed intravascularly in all cAVM samples but not other samples. Nidi of AVMs showed migration of many Iba-I-positive cells adjacent to the endothelium and endothelial COX2 expression, accompanied by expression of IL-6 and IL-8 in the endothelium and intravascular neutrophils. Unexpectedly, expression of CitH3 was not necessarily localized to the vascular wall and thrombus. Our results offer the first evidence of intravascular expression of NETs, which might be associated with vascular inflammation in cAVMs.
(徳島大学機関リポジトリ): ● Metadata: 116871
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.wneu.2021.08.118
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34478890; ● Summary page in Scopus @ Elsevier: 2-s2.0-85115331132

(徳島大学機関リポジトリ: 116871, DOI: 10.1016/j.wneu.2021.08.118, PubMed: 34478890, Elsevier: Scopus) Masaaki Korai, Yasuhisa Kanematsu, Izumi Yamaguchi, Tadashi Yamaguchi, Yuki Yamamoto, Nobuaki Yamamoto, Takeshi Miyamoto, Kenji Shimada, Junichiro Satomi, Mami Hanaoka, Kazuhito Matsuzaki, Koichi Satoh and Yasushi Takagi :
Subarachnoid Hemorrhage Due to Rupture of Vertebral Artery Dissecting Aneurysms: Treatments, Outcomes, and Prognostic Factors,
World Neurosurgery, Vol.152, e86-e93, 2021.

(要約): Mortality rate after subarachnoid hemorrhage due to rupture of vertebral artery dissecting aneurysms (VADAs) is high; endovascular coil trapping is the first-line therapy to prevent rerupture. To select optimal treatments, the positional relationship between the VADA and posterior inferior cerebellar artery (PICA) and the morphology of the contralateral vertebral artery must be considered, and outcome predictors of different treatment methods and their possible complications must be identified. We retrospectively studied 44 patients with ruptured VADAs who had undergone endovascular or surgical treatment. VADA morphology was assessed on conventional preoperative angiograms, and VADAs were categorized based on their site in relation to the PICA. VADA site, treatment method, and complications were used to identify prognostic factors. The sites of the 44 VADAs were PICA-proximal (n = 3), PICA-distal (n = 22), PICA-absent (n = 7), and PICA-involved (n = 12). Treatments included internal coil trapping (n = 30), proximal coil occlusion (n = 5), and stent placement (n = 3); surgical flow alteration via an occipital artery-PICA bypass and ligation at the proximal vertebral artery and the PICA origin was performed in 6 patients. Periprocedural rebleeding was associated with a poor outcome. Internal coil trapping prevented the rerupture of PICA-proximal and PICA-absent VADAs, and flow alteration prevented rerupture of PICA-involved VADAs; there were no complications directly attributable to these procedures. Periprocedural rebleeding was a poor prognostic factor. Internal trapping of PICA-proximal and PICA-absent VADAs and flow alteration in PICA-involved VADAs prevented rerupture.
(キーワード): Adult / Aged / Aged, 80 and over / Aneurysm, Ruptured / Follow-Up Studies / Humans / Male / Middle Aged / Prognosis / Retrospective Studies / Subarachnoid Hemorrhage / Treatment Outcome / Vertebral Artery Dissection
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.wneu.2021.05.018
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34051365; ● Search Scopus @ Elsevier (PMID): 34051365; ● Search Scopus @ Elsevier (DOI): 10.1016/j.wneu.2021.05.018

(DOI: 10.1016/j.wneu.2021.05.018, PubMed: 34051365) Ryoma Morigaki, Ryosuke Miyamoto, Taku Matsuda, Kazuhisa Miyake, Nobuaki Yamamoto and Yasushi Takagi :
Dystonia and cerebellum: From bench to bedside,
Life, Vol.11, No.8, 776, 2021.

(徳島大学機関リポジトリ): ● Metadata: 116560
(出版サイトへのリンク): ● Publication site (DOI): 10.3390/life11080776
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.3390/life11080776

(徳島大学機関リポジトリ: 116560, DOI: 10.3390/life11080776) Kenji Shono, Yoshifumi Mizobuchi, Izumi Yamaguchi, Kohhei Nakajima, Yuri Fujiwara, Toshitaka Fujihara, Keiko Kitazato, Kazuhito Matsuzaki, Yoshihiro Uto, Oltea Sampetrean, Hideyuki Saya and Yasushi Takagi :
Elevated cellular PpIX potentiates sonodynamic therapy in a mouse glioma stem cell-bearing glioma model by downregulating the Akt/NF-κB/MDR1 pathway.,
Scientific Reports, Vol.11, No.1, 2021.

(要約): Glioblastoma (GBM) has high mortality rates because of extreme therapeutic resistance. During surgical resection for GBM, 5-aminolevulinic acid (5-ALA)-induced protoporphyrin IX (PpIX) fluorescence is conventionally applied to distinguish GBM. However, surgical intervention is insufficient for high invasive GBM. Sonodynamic therapy (SDT) combined with low-intensity ultrasonication (US) and PpIX, as a sonosensitizer, is an emerging and promising approach, although its efficacy is limited. Based on our previous study that down-regulation of multidrug resistant protein (MDR1) in GBM augmented the anti-tumor effects of chemotherapy, we hypothesized that elevation of cellular PpIX levels by down-regulation of MDR1 enhances anti-tumor effects by SDT. In high invasive progeny cells from mouse glioma stem cells (GSCs) and a GSC-bearing mouse glioma model, we assessed the anti-tumor effects of SDT with a COX-2 inhibitor, celecoxib. Down-regulation of MDR1 by celecoxib increased cellular PpIX levels, as well as valspodar, an MDR1 inhibitor, and augmented anti-tumor effects of SDT. MDR1 down-regulation via the Akt/NF-κB pathway by celecoxib was confirmed, using an NF-κB inhibitor, CAPÉ. Thus, elevation of cellar PpIX by down-regulation of MDR1 via the Akt/NF-κB pathway may be crucial to potentiate the efficacy of SDT in a site-directed manner and provide a promising new therapeutic strategy for GBM.
(キーワード): ATP Binding Cassette Transporter, Subfamily B, Member 1 / Aminolevulinic Acid / Animals / Cell Line, Tumor / Down-Regulation / Glioblastoma / Glioma / Male / Mice / Mice, Inbred C57BL / NF-kappa B / Neoplastic Stem Cells / Photosensitizing Agents / Proto-Oncogene Proteins c-akt / Protoporphyrins / Signal Transduction / Ultrasonic Therapy
(徳島大学機関リポジトリ): ● Metadata: 116448
(出版サイトへのリンク): ● Publication site (DOI): 10.1038/s41598-021-93896-0
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34301977; ● Search Scopus @ Elsevier (PMID): 34301977; ● Search Scopus @ Elsevier (DOI): 10.1038/s41598-021-93896-0

(徳島大学機関リポジトリ: 116448, DOI: 10.1038/s41598-021-93896-0, PubMed: 34301977) Yasuhisa Kanematsu, Kenji Shimada, Yoshiteru Tada, Masaaki Korai, Takeshi Miyamoto, Shu Sogabe, Izumi Yamaguchi, Yoko Ymamoto, Nobuaki Yamamoto, Yuki Yamamoto, Koichi Satoh and Yasushi Takagi :
Coil embolization with overlapping horizontal low-profile stents to treat a giant thrombosed fetal posterior cerebral aneurysm using contralateral approach through anterior communicating artery: Case report.,
Surgical Neurology International, Vol.12, No.347, 2021.

(要約): The treatment of internal carotid artery (ICA) - posterior communicating artery aneurysms (ICPC aneurysms) is challenging when a fetal posterior cerebral artery (PCA) arises from the saccular neck. This complex angioarchitecture renders endovascular approaches difficult. Giant thrombosed IC-PC aneurysms are also hard to treat by endovascular coiling because its flow-diversion effect is insufficient. We report the first case of a ruptured giant thrombosed IC-PC aneurysm associated with a fetal PCA that was successfully treated by coil embolization with retrograde overlap horizontal stenting using low-profile stents introduced through the contralateral ICA. The aneurysm was completely occluded and follow-up MRI scans demonstrated the reduction of the aneurysmal size. Our technique is advantageous because low-profile stents can be used to treat lesions not accessible with flow-diverter stents due their presence in complex angioarchitectures, and overlap stenting may have flow-diversion effects that can result in the complete occlusion of giant thrombosed aneurysms.
(徳島大学機関リポジトリ): ● Metadata: 119411
(出版サイトへのリンク): ● Publication site (DOI): 10.25259/SNI_533_2021
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34345487; ● Search Scopus @ Elsevier (PMID): 34345487; ● Search Scopus @ Elsevier (DOI): 10.25259/SNI_533_2021

(徳島大学機関リポジトリ: 119411, DOI: 10.25259/SNI_533_2021, PubMed: 34345487) Pham Tran Phuong, Daiju Fukuda, Sachiko Nishimoto, JR Kim-Kaneyama, XF Lei, Yutaka Takahashi, Tomohito Sato, Kimie Tanaka, Kumiko Suto, Yutaka Kawabata, Koji Yamaguchi, Shusuke Yagi, Kenya Kusunose, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Kenji Shimada, Yasuhisa Kanematsu, Yasushi Takagi, Michio Shimabukuro, Mitsutoshi Setou, Glen N Barber and Masataka Sata :
STING, a cytosolic DNA sensor, plays a critical role in atherogenesis: a link between innate immunity and chronic inflammation caused by lifestyle-related diseases,
European Heart Journal, Vol.42, No.42, 4336-4348, 2021.

(要約): Lifestyle-related diseases promote atherosclerosis, a chronic inflammatory disease; however, the molecular mechanism remains largely unknown. Endogenous DNA fragments released under over-nutrient condition provoke sterile inflammation through the recognition by DNA sensors. Here, we investigated the role of stimulator of interferon genes (STING), a cytosolic DNA sensor, in atherogenesis. Apolipoprotein E-deficient (Apoe-/-) mice fed a western-type diet (WTD), a hypercholesterolaemic mouse model, showed higher STING expression and markers for DNA damage such as γH2AX, p53, and single-stranded DNA (ssDNA) accumulation in macrophages in the aorta compared with wild-type (WT) mice. The level of cGAMP, a STING agonist, in the aorta was higher in Apoe-/- mice. Genetic deletion of Sting in Apoe-/- mice reduced atherosclerotic lesions in the aortic arch, lipid, and macrophage accumulation in plaques, and inflammatory molecule expression in the aorta compared with the control. Pharmacological blockade of STING using a specific inhibitor, C-176, ameliorated atherogenesis in Apoe-/- mice. In contrast, bone marrow-specific STING expression in Apoe-/- mice stimulated atherogenesis. Expression or deletion of STING did not affect metabolic parameters and blood pressure. In vitro studies revealed that STING activation by cGAMP or mitochondrial DNA accelerated inflammatory molecule expression (e.g. TNF-α or IFN-β) in mouse and human macrophages. Activation of nuclear factor-κB and TANK binding kinase 1 was involved in STING-associated vascular inflammation and macrophage activation. Furthermore, human atherosclerotic lesions in the carotid arteries expressed STING and cGAMP. Stimulator of interferon genes stimulates pro-inflammatory activation of macrophages, leading to the development of atherosclerosis. Stimulator of interferon genes signalling may serve as a potential therapeutic target for atherosclerosis.
(出版サイトへのリンク): ● Publication site (DOI): 10.1093/eurheartj/ehab249
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34226923; ● Summary page in Scopus @ Elsevier: 2-s2.0-85120384111

(DOI: 10.1093/eurheartj/ehab249, PubMed: 34226923, Elsevier: Scopus) Kenji Shimada, Yoko Yamamoto, Takeshi Miyamoto, Shu Sogabe, Toshitaka Fujihara, Kohhei Nakajima, Yoshifumi Mizobuchi, Yasuhisa Kanematsu and Yasushi Takagi :
Efficacy of Intra-arterial Indocyanine Green Videoangiography in Hemangioblastoma Surgery: A Case Report.,
NMC Case Report Journal, Vol.8, No.1, 295-300, 2021.

(要約): Intravenous indocyanine green (ICG) videoangiography is reportedly useful for vascular neurosurgery, and for treating hemangioblastoma due to its high vascularity. Videoangiography obtained after intra-arterial ICG injection has emerged as a more useful option than that after intravenous injection. This report offers the first description of a case of hemangioblastoma successfully treated using intra-arterial ICG videoangiography, and describes the efficacy of this technique. A 20-year-old man presented with progressive cerebellar ataxia and dysphagia. Magnetic resonance imaging (MRI) revealed an enhanced solid tumor in the medulla oblongata. Digital subtraction angiography (DSA) showed a highly vascularized tumor. Surgery was performed to remove the tumor in a hybrid operating room. A catheter was introduced into the vertebral artery (VA) for intra-arterial ICG videoangiography. Superficial feeders and drainers were identified and flow dynamic changes in the tumor were assessed by intra-arterial ICG videoangiography. The tumor was removed after confirming lack of flow in the drainer. Intra-arterial ICG videoangiography was more useful than intravenous ICG videoangiography in hemangioblastoma surgery for identifying feeders and drainers and assessing flow dynamics in the tumor. Use of Flow 800 made these findings simpler and easier to evaluate.
(出版サイトへのリンク): ● Publication site (DOI): 10.2176/nmccrj.cr.2020-0281
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35079478; ● Search Scopus @ Elsevier (PMID): 35079478; ● Search Scopus @ Elsevier (DOI): 10.2176/nmccrj.cr.2020-0281

(DOI: 10.2176/nmccrj.cr.2020-0281, PubMed: 35079478) Nobuaki Yamamoto, Yuki Yamamoto, Izumi Yamaguchi, Shu Sogabe, Takeshi Miyamoto, Kenji Shimada, Yasuhisa Kanematsu, Ryoma Morigaki, Yuishin Izumi and Yasushi Takagi :
Percutaneous Transluminal Angioplasty and Stenting Using an Aspiration Catheter,
Journal of Neuroendovascular Therapy, Vol.16, No.5, 277-282, 2021.

(要約): Objective: During percutaneous transluminal angioplasty (PTA) for the vertebral artery, occlusion of the subclavian artery using a balloon guiding catheter may be useful to prevent embolism of clots and/or debris distal to an atherosclerotic lesion. However, when placing a balloon guiding catheter at the intended vessels is difficult, it may be useful to use an aspiration catheter (AC) for mechanical thrombectomy as an intermediate catheter to suction way clots and/or debris. We report two cases in which PTA was performed for an atherosclerotic lesion at the intracranial vertebral artery using an AC, which ended without complications.Case Presentations: Case 1: A 74-year-old man presented with dysarthria and was admitted to our hospital. MRI revealed severe left vertebral artery stenosis and diffuse cerebral infarct areas at the territory of the posterior circulation. The patient had an abdominal aortic aneurysm and abnormally shaped left tortuous subclavian artery. Therefore, we performed PTA and stenting via the left brachial artery. We guided a 6-Fr long sheath to the left subclavian artery, and a 6-Fr AC for thrombectomy was guided through the long sheath to the V4 portion of the left vertebral artery. Thereafter, PTA was carried out under manual aspiration from the AC. As restenosis at the atherosclerotic lesion occurred after PTA, we performed stenting using a coronary stent system for this lesion under manual aspiration from the AC. No new infarct areas were observed on post-procedural MRI. Case 2: A 74-year-old woman presented with dysarthria and was admitted to our hospital. MRI demonstrated basilar artery occlusion and diffuse cerebral infarct areas at the territory of the posterior circulation. As her symptom worsened after admission, we performed urgent mechanical thrombectomy. We first performed thrombectomy using a stent retriever and then performed PTA and stenting (PTAS) for residual basilar artery stenosis via the AC under manual aspiration.Conclusion: When it is difficult to place a guiding catheter at the intended vessels during PTA, an AC may be useful to prevent distal embolization.
(キーワード): percutaneous transluminal angioplasty / aspiration catheter
(出版サイトへのリンク): ● Publication site (DOI): 10.5797/jnet.cr.2021-0030
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390573593425698304; ● Search Scopus @ Elsevier (DOI): 10.5797/jnet.cr.2021-0030

(DOI: 10.5797/jnet.cr.2021-0030, CiNii: 1390573593425698304) Hiroshi Koyama, Hideo Mure, Ryoma Morigaki, Ryosuke Miyamoto, Kazuhisa Miyake, Taku Matsuda, Koji Fujita, Yuishin Izumi, Ryuji Kaji, Satoshi Goto and Yasushi Takagi :
Long-Term Follow-Up of 12 Patients Treated with Bilateral Pallidal Stimulation for Tardive Dystonia,
Life, Vol.11, No.6, 477, 2021.

(要約): Tardive dystonia (TD) is a side effect of prolonged dopamine receptor antagonist intake. TD can be a chronic disabling movement disorder despite medical treatment. We previously demonstrated successful outcomes in six patients with TD using deep brain stimulation (DBS); however, more patients are needed to better understand the efficacy of DBS for treating TD. We assessed the outcomes of 12 patients with TD who underwent globus pallidus internus (GPi) DBS by extending the follow-up period of previously reported patients and enrolling six additional patients. All patients were refractory to pharmacotherapy and were referred for surgical intervention by movement disorder neurologists. In all patients, DBS electrodes were implanted bilaterally within the GPi under general anesthesia. The mean ages at TD onset and surgery were 39.2 ± 12.3 years and 44.6 ± 12.3 years, respectively. The Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS) performed the preoperative and postoperative evaluations. The average BFMDRS improvement rate at 1 month postoperatively was 75.6 ± 27.6% ( < 0.001). Ten patients were assessed in the long term (78.0 ± 50.4 months after surgery), and the long-term BFMDRS improvement was 78.0 ± 20.4%. Two patients responded poorly to DBS. Both had a longer duration from TD onset to surgery and older age at surgery. A cognitive and psychiatric decline was observed in the oldest patients, while no such decline ware observed in the younger patients. In most patients with TD, GPi-DBS could be a beneficial therapeutic option for long-term relief of TD.
(徳島大学機関リポジトリ): ● Metadata: 116561
(出版サイトへのリンク): ● Publication site (DOI): 10.3390/life11060477
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34074009; ● Summary page in Scopus @ Elsevier: 2-s2.0-85107554331

(徳島大学機関リポジトリ: 116561, DOI: 10.3390/life11060477, PubMed: 34074009, Elsevier: Scopus) Kohei Muto, Ryosuke Miyamoto, Yuka Terasawa, Yoshimitsu Shimatani, Keijiro Hara, Takumi Kakimoto, Tatsuya Fukumoto, Yusuke Osaki, Koji Fujita, Masafumi Harada, Hisanori Uehara, Yasushi Takagi and Yuishin Izumi :
A novel COL4A1 variant associated with recurrent epistaxis and glioblastoma,
Human Genome Variation, Vol.8, No.1, 18, 2021.

(徳島大学機関リポジトリ): ● Metadata: 116530
(出版サイトへのリンク): ● Publication site (DOI): 10.1038/s41439-021-00150-0
(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-85105944271

(徳島大学機関リポジトリ: 116530, DOI: 10.1038/s41439-021-00150-0, Elsevier: Scopus) Yoshifumi Mizobuchi, Aki Shimada, Kohhei Nakajima, Hiroshi Kagusa and Yasushi Takagi :
Reversible Hearing Impairment Due to Inferior Colliculi Compression by a Pineal Glial Cyst,
NMC Case Report Journal, Vol.8, No.1, 79-84, 2021.

(出版サイトへのリンク): ● Publication site (DOI): 10.2176/nmccrj.cr.2020-0123
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34012754; ● CiNii @ 国立情報学研究所 (CRID): 1390850247501001984; ● Search Scopus @ Elsevier (PMID): 34012754; ● Search Scopus @ Elsevier (DOI): 10.2176/nmccrj.cr.2020-0123

(DOI: 10.2176/nmccrj.cr.2020-0123, PubMed: 34012754, CiNii: 1390850247501001984) Manabu Ishihara, Nobuto Nakanishi, Rie Tsutsumi, Kanako Hara, Kyoka Machida, Nobuaki Yamamoto, Yasuhisa Kanematsu, Hiroshi Sakaue, Jun Oto and Yasushi Takagi :
Elevated Urinary Titin and its Associated Clinical Outcomes after Acute Stroke.,
Journal of Stroke & Cerebrovascular Diseases, Vol.30, No.3, 2021.

(要約): Forty-one patients were included (29 male; age, 68 ± 15 years), 29 had ischemic stroke, 8 had intracerebral hemorrhage, and 4 had subarachnoid hemorrhage. The levels of urinary titin on days 1, 3, 5, and 7 were 9.9 (4.7-21.1), 16.2 (8.6-22.0), 8.9 (4.8-15.2), and 8.7 (3.6-16.2) pmol/mg Cr, respectively. The peak urinary titin level was associated with the mRS score (r = 0.55, p < 0.01), the NIHSS score (r = 0.72, p < 0.01), and the BI (r = -0.59, p < 0.01) upon hospital discharge. In multivariate analysis, the peak urinary titin was associated with poor outcome (p = 0.03).
(キーワード): Aged / Aged, 80 and over / Biomarkers / Connectin / Disability Evaluation / Female / Functional Status / Humans / Male / Middle Aged / Patient Discharge / Predictive Value of Tests / Prospective Studies / Recovery of Function / Stroke / Time Factors / Treatment Outcome / Up-Regulation / Urinalysis
(徳島大学機関リポジトリ): ● Metadata: 119486
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jstrokecerebrovasdis.2020.105561
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33360523; ● Search Scopus @ Elsevier (PMID): 33360523; ● Search Scopus @ Elsevier (DOI): 10.1016/j.jstrokecerebrovasdis.2020.105561

(徳島大学機関リポジトリ: 119486, DOI: 10.1016/j.jstrokecerebrovasdis.2020.105561, PubMed: 33360523) Kohhei Nakajima, Yoshifumi Mizobuchi, Toshitaka Fujihara, Mai Azumi and Yasushi Takagi :
Continued-Maintenance Therapy with High-dose Methotrexate Improves Overall Survival of Patients with Primary Central Nervous System Lymphoma.,
The Journal of Medical Investigation : JMI, Vol.68, No.3.4, 286-291, 2021.

(要約): In 3-year overall survival (OS) there was a statistically significant difference between the two groups [controls : 33.1% (95%, CI 12.4 - 55.7%) ; maintenance group : 74.9% (95%, CI 55.6 - 86.7%) (p < 0.02)]. Conclusion : The induction of HD-MTX based chemotherapy followed by continued-maintenance HD-MTX monotherapy improved OS compared with chemoradiotherapy consisting of HD-MTX followed by WBRT. J. Med. Invest. 68 : 286-291, August, 2021.
(キーワード): Aged / Antineoplastic Combined Chemotherapy Protocols / Central Nervous System / Central Nervous System Neoplasms / Humans / Lymphoma, Non-Hodgkin / Methotrexate / Retrospective Studies
(徳島大学機関リポジトリ): ● Metadata: 116496
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.68.286
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34759146; ● Search Scopus @ Elsevier (PMID): 34759146; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.68.286

(徳島大学機関リポジトリ: 116496, DOI: 10.2152/jmi.68.286, PubMed: 34759146) Daisy Ma Tabuena, Ryoma Morigaki, Ryosuke Miyamoto, Hideo Mure, Nobuaki Yamamoto, Kazuhisa Miyake, Taku Matsuda, Yuishin Izumi, Yasushi Takagi, P Rollin Tabuena and Toshitaka Kawarai :
Ataxia with vitamin E deficiency in the Philippines: A case report of two siblings.,
The Journal of Medical Investigation : JMI, Vol.68, No.3.4, 400-403, 2021.

(要約): Here we report two siblings with ataxia and peripheral neuropathy. One patient showed head tremors. Genetic analysis revealed a mutation in the hepatic α-tocopherol transfer protein (α-TTP) gene (TTPA) on chromosome 8q13. They were diagnosed with ataxia with vitamin E deficiency which is firstly reported in the Philippines. As the symptoms of ataxia with vitamin E deficiency can be alleviated with lifelong vitamin E administration, differential diagnosis from similar syndromes is important. In addition, ataxia with vitamin E deficiency causes movement disorders. Therefore, a common hereditary disease in the Philippines, X-linked dystonia-parkinsonism, could be another differential diagnosis. The Philippines is an archipelago comprising 7,107 islands, and the prevalence of rare hereditary diseases among the populations of small islands is still unclear. For neurologists, establishing a system of genetic diagnosis and counseling in rural areas remains challenging. These unresolved problems should be addressed in the near future. J. Med. Invest. 68 : 400-403, August, 2021.
(キーワード): Ataxia / Humans / Philippines / Siblings / Vitamin E Deficiency
(徳島大学機関リポジトリ): ● Metadata: 116574
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.68.400
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34759169; ● Search Scopus @ Elsevier (PMID): 34759169; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.68.400

(徳島大学機関リポジトリ: 116574, DOI: 10.2152/jmi.68.400, PubMed: 34759169) Izumi Yamaguchi, Yasuhisa Kanematsu, Kenji Shimada, Kohhei Nakajima, Takeshi Miyamoto, Shu Sogabe, Eiji Shikata, Manabu Ishihara, Mai Azumi, Ayato Kageyama and Yasushi Takagi :
Gelatinthrombin Hemostatic Matrix-related Cyst Formation after Cerebral Hematoma Evacuation: A Report of Two Cases,
NMC Case Report Journal, Vol.8, No.1, 719-725, 2021.

(出版サイトへのリンク): ● Publication site (DOI): 10.2176/nmccrj.cr.2021-0130
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.2176/nmccrj.cr.2021-0130

(DOI: 10.2176/nmccrj.cr.2021-0130) Nobuaki Yamamoto, Yuishin Izumi, Yuki Yamamoto, K Kuroda, Izumi Yamaguchi, Shu Sogabe, Takeshi Miyamoto, Kenji Shimada, Yasuhisa Kanematsu, Ryoma Morigaki and Yasushi Takagi :
Factors associated with DWI-ASPECTS score in patients with acute ischemic stroke due to cerebral large vessel occlusion,
Clinical Neurology and Neurosurgery, Vol.199, 106316, 2020.

(要約): The Alberta Stroke Program Early CT score (ASPECTS) of patients with acute ischemic stroke at the time of admission varies. It is crucial to select appropriate methods of treatment, such as recombinant tissue-plasminogen activator, and/or endovascular thrombectomy. According to the recent guidelines, endovascular thrombectomy for patients with large vessel occlusion (LVO) and lesion of ischemic tissue that was not yet infarcted is effective. This result demonstrates the importance of patient selection based on neuroradiological imaging. However, there are many patients who are judged as ineligibility for recanalization therapy because of presence of large ischemic core, indicating unfavorable ASPECTS, at the time of admission. We investigated the factors associated with favorable diffusion-weighted image (DWI)-ASPECTS score at the time of admission. We studies patients with LVO within 24 h from onset who were admitted into our hospital. We divided them into two groups, with favorable DWI-ASPECTS (≥6), and unfavorable DWI-ASPECTS (<6) at the time of admission. We investigated factors associated with favorable DWI-ASPECTS by evaluation of our patients' severity of clinical symptom, etiology, and radiological findings. This study showed that mild white matter lesion (Fazekas scale ≤1), absence of internal carotid artery (ICA) occlusion and cardioembolic stroke were independent factor of favorable DWI-ASPECTS at the time of admission. (odds ratio 12.92, p < 0.001, odds ratio 0.31, p = 0.001, odds ratio 0.16, p = 0.001, respectively) CONCLUSIONS: Absence of severe white matter lesion, cardioembolic stroke, and ICA occlusion might be associated with favorable DWI-ASPECTS at the time of admission.
(キーワード): Aged / Aged, 80 and over / Brain Ischemia / Cerebrovascular Disorders / Diffusion Magnetic Resonance Imaging / Female / Humans / Ischemic Stroke / Male / Middle Aged / Patient Admission / Prospective Studies / Retrospective Studies / Severity of Illness Index
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.clineuro.2020.106316
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33161217; ● Search Scopus @ Elsevier (PMID): 33161217; ● Search Scopus @ Elsevier (DOI): 10.1016/j.clineuro.2020.106316

(DOI: 10.1016/j.clineuro.2020.106316, PubMed: 33161217) Kenji Shono, Izumi Yamaguchi, Yoshifumi Mizobuchi, Hiroshi Kagusa, Akiko Sumi, Toshitaka Fujihara, Kohhei Nakajima, T Keiko Kitazato, Kazuhito Matsuzaki, Hideyuki Saya and Yasushi Takagi :
Downregulation of the CCL2/CCR2 and CXCL10/CXCR3 axes contributes to antitumor effects in a mouse model of malignant glioma.,
Scientific Reports, Vol.10, No.1, 2020.

(要約): Glioblastoma multiforme involves glioma stem cells (GSCs) that are resistant to various therapeutic approaches. Here, we studied the importance of paracrine signaling in the glioma microenvironment by focusing on the celecoxib-mediated role of chemokines C-C motif ligand 2 (CCL2), C-X-C ligand 10 (CXCL10), and their receptors, CCR2 and CXCR3, in GSCs and a GSC-bearing malignant glioma model. C57BL/6 mice were injected with orthotopic GSCs intracranially and divided into groups administered either 10 or 30 mg/kg celecoxib, or saline to examine the antitumor effects associated with chemokine expression. In GSCs, we analyzed cell viability and expression of chemokines and their receptors in the presence/absence of celecoxib. In the malignant glioma model, celecoxib exhibited antitumor effects in a dose dependent manner and decreased protein and mRNA levels of Ccl2 and CxcL10 and Cxcr3 but not of Ccr2. CCL2 and CXCL10 co-localized with Nestin
(キーワード): Animals / Antineoplastic Agents / Cell Line / Chemokine CCL2 / Chemokine CXCL10 / Disease Models, Animal / Down-Regulation / Glioma / Humans / Male / Mice / Mice, Inbred C57BL / Microglia / Receptors, CCR2 / Receptors, CXCR3 / Stem Cells / Tumor Microenvironment
(徳島大学機関リポジトリ): ● Metadata: 117722
(出版サイトへのリンク): ● Publication site (DOI): 10.1038/s41598-020-71857-3
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32943658; ● Search Scopus @ Elsevier (PMID): 32943658; ● Search Scopus @ Elsevier (DOI): 10.1038/s41598-020-71857-3

(徳島大学機関リポジトリ: 117722, DOI: 10.1038/s41598-020-71857-3, PubMed: 32943658) Ryoma Morigaki, Ryosuke Miyamoto, Hideo Mure, Koji Fujita, Taku Matsuda, Yoko Yamamoto, Masahito Nakataki, Tetsuya Okahisa, Yuki Matsumoto, Kazuhisa Miyake, Nobuaki Yamamoto, Ryuji Kaji, Yasushi Takagi and Satoshi Goto :
Can Pallidal Deep Brain Stimulation Rescue Borderline Dystonia? Possible Coexistence of Functional (Psychogenic) and Organic Components.,
Brain Sciences, Vol.10, No.9, 636, 2020.

(要約): The diagnosis and treatment of functional movement disorders are challenging for clinicians who manage patients with movement disorders. The borderline between functional and organic dystonia is often ambiguous. Patients with functional dystonia are poor responders to pallidal deep brain stimulation (DBS) and are not good candidates for DBS surgery. Thus, if patients with medically refractory dystonia have functional features, they are usually left untreated with DBS surgery. In order to investigate the outcome of functional dystonia in response to pallidal DBS surgery, we retrospectively included five patients with this condition. Their dystonia was diagnosed as organic by dystonia specialists and also as functional according to the Fahn and Williams criteria or the Gupta and Lang Proposed Revisions. Microelectrode recordings in the globus pallidus internus of all patients showed a cell-firing pattern of bursting with interburst intervals, which is considered typical of organic dystonia. Although their clinical course after DBS surgery was incongruent to organic dystonia, the outcome was good. Our results question the possibility to clearly differentiate functional dystonia from organic dystonia. We hypothesized that functional dystonia can coexist with organic dystonia, and that medically intractable dystonia with combined functional and organic features can be successfully treated by DBS surgery.
(徳島大学機関リポジトリ): ● Metadata: 116502
(出版サイトへのリンク): ● Publication site (DOI): 10.3390/brainsci10090636
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32942724; ● Search Scopus @ Elsevier (PMID): 32942724; ● Search Scopus @ Elsevier (DOI): 10.3390/brainsci10090636

(徳島大学機関リポジトリ: 116502, DOI: 10.3390/brainsci10090636, PubMed: 32942724) Hideo Mure, Naoto Toyoda, Ryoma Morigaki, Koji Fujita and Yasushi Takagi :
Clinical Outcome and Intraoperative Neurophysiology of the Lance-Adams Syndrome Treated with Bilateral Deep Brain Stimulation of the Globus Pallidus Internus: A Case Report and Review of the Literature.,
Stereotactic and Functional Neurosurgery, Vol.98, No.6, 399-403, 2020.

(要約): Our results show that impairment in the basal ganglion circuitry might be involved in the pathogenesis of myoclonus in patients with LAS.
(キーワード): Aged / Deep Brain Stimulation / Female / Globus Pallidus / Humans / Hypoxia-Ischemia, Brain / Intraoperative Neurophysiological Monitoring / Microelectrodes / Myoclonus / Treatment Outcome
(出版サイトへのリンク): ● Publication site (DOI): 10.1159/000509318
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32894852; ● Search Scopus @ Elsevier (PMID): 32894852; ● Search Scopus @ Elsevier (DOI): 10.1159/000509318

(DOI: 10.1159/000509318, PubMed: 32894852) Yuki Kanazawa, Masafumi Harada, Mitsuharu Miyoshi, Takashi Abe, Yuki Matsumoto and Yasushi Takagi :
Characterization of Brain Tumors using Amide Proton and Nuclear Overhauser Effect at 3 Tesla MR Scanner,
Proceedings of the 28th Virtual Conference of ISMRM, No.1697, 2020. Yuki Kanazawa, Masafumi Harada, Tosiaki Miyati, Takashi Abe, Mitsuharu Miyoshi, Yuki Matsumoto, Hiroaki Hayashi, Yasuhisa Kanematsu and Yasushi Takagi :
Chemical Exchange Saturation Transfer Imaging for Atherosclerotic Plaques,
Proceedings of 28th Virtual Meeting of ISMRM, No.2128, 2020. Shotaroh Yoshioka, Takeshi Miyamoto, Junichiro Satomi, Yoshiteru Tada, Kenji Yagi, Kenji Shimada, Koji Naruishi, Eiji Shikata, Izumi Yamaguchi, Tadashi Yamaguchi, Masaaki Korai, Yoshihiro Okayama, Masafumi Harada, Keiko Kitazato, Yasuhisa Kanematsu, Shinji Nagahiro and Yasushi Takagi :
Disequilibrium of Plasma Protease/Anti-Protease Due to Severe Periodontal Disease Contributes to Human Subarachnoid Hemorrhage,
Neurosurgery Open, Vol.1, No.3, 1-9, 2020.

(徳島大学機関リポジトリ): ● Metadata: 115292
(出版サイトへのリンク): ● Publication site (DOI): 10.1093/neuopn/okaa007
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1093/neuopn/okaa007

(徳島大学機関リポジトリ: 115292, DOI: 10.1093/neuopn/okaa007) Koga Masatoshi, Yamamoto Haruko, Inoue Manabu, Asakura Koko, Aoki Junya, Hamasaki Toshimitsu, Kanzawa Takao, Kondo Rei, Ohtaki Masafumi, Itabashi Ryo, Kamiyama Kenji, Iwama Toru, Nakase Taizen, Yakushiji Yusuke, Igarashi Shuichi, Nagakane Yoshinari, Takizawa Shunya, Okada Yasushi, Doijiri Ryosuke, Tsujino Akira, Ito Yasuhiro, Ohnishi Hideyuki, Inoue Takeshi, Yasushi Takagi, Hasegawa Yasuhiro, Shiokawa Yoshiaki, Sakai Nobuyuki, Osaki Masato, Uesaka Yoshikazu, Yoshimura Shinichi, Urabe Takao, Ueda Toshihiro, Ihara Masafumi, Kitazono Takanari, Sasaki Makoto, Oita Akira, Yoshimura Sohei, Fukuda-Doi Mayumi, Miwa Kaori, Kimura Kazumi, Minematsu Kazuo, Toyoda Kazunori and Investigators Trial THAWS :
Thrombolysis With Alteplase at 0.6 mg/kg for Stroke With Unknown Time of Onset: A Randomized Controlled Trial.,
Stroke, Vol.51, No.5, 1530-1538, 2020.

(要約): Background and Purpose- We assessed whether lower-dose alteplase at 0.6 mg/kg is efficacious and safe for acute fluid-attenuated inversion recovery-negative stroke with unknown time of onset. Methods- This was an investigator-initiated, multicenter, randomized, open-label, blinded-end point trial. Patients met the standard indication criteria for intravenous thrombolysis other than a time last-known-well >4.5 hours (eg, wake-up stroke). Patients were randomly assigned (1:1) to receive alteplase at 0.6 mg/kg or standard medical treatment if magnetic resonance imaging showed acute ischemic lesion on diffusion-weighted imaging and no marked corresponding hyperintensity on fluid-attenuated inversion recovery. The primary outcome was a favorable outcome (90-day modified Rankin Scale score of 0-1). Results- Following the early stop and positive results of the WAKE-UP trial (Efficacy and Safety of MRI-Based Thrombolysis in Wake-Up Stroke), this trial was prematurely terminated with 131 of the anticipated 300 patients (55 women; mean age, 74.4±12.2 years). Favorable outcome was comparable between the alteplase group (32/68, 47.1%) and the control group (28/58, 48.3%; relative risk [RR], 0.97 [95% CI, 0.68-1.41]; =0.892). Symptomatic intracranial hemorrhage within 22 to 36 hours occurred in 1/71 and 0/60 (RR, infinity [95% CI, 0.06 to infinity]; >0.999), respectively. Death at 90 days occurred in 2/71 and 2/60 (RR, 0.85 [95% CI, 0.06-12.58]; >0.999), respectively. Conclusions- No difference in favorable outcome was seen between alteplase and control groups among patients with ischemic stroke with unknown time of onset. The safety of alteplase at 0.6 mg/kg was comparable to that of standard treatment. Early study termination precludes any definitive conclusions. Registration- URL: https://www.clinicaltrials.gov; Unique identifier: NCT02002325.
(徳島大学機関リポジトリ): ● Metadata: 115806
(出版サイトへのリンク): ● Publication site (DOI): 10.1161/STROKEAHA.119.028127
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32248771; ● Search Scopus @ Elsevier (PMID): 32248771; ● Search Scopus @ Elsevier (DOI): 10.1161/STROKEAHA.119.028127

(徳島大学機関リポジトリ: 115806, DOI: 10.1161/STROKEAHA.119.028127, PubMed: 32248771) Akemi Hioka, Yoshiteru Tada, Keiko Kitazato, Naoki Akazawa, Yasushi Takagi and Shinji Nagahiro :
Action observation treatment improves gait ability in subacute to convalescent stroke patients.,
Journal of Clinical Neuroscience, Vol.75, 55-61, 2020.

(要約): The aim of this study was to investigate the effects of action observation treatment (AOT) on gait ability in patients with subacute to convalescent stroke. Sixteen patients with subacute stroke were divided into a control group (n = 8) and AOT group (n = 8) when admitted to the convalescent ward. The control group received a conventional rehabilitation only. In addition to conventional rehabilitation, the AOT received AOT for 3 months (30 min per day 5 times per week). The AOT involved observing the action of another subject in a comfortable gait situation from the front, sides, and back via video and conducting the actual action. All participants were assessed during the main-assessment period, which included a baseline (i.e., when admitted to the convalescent ward) and 1, 2, and 3 months after baseline. The sub-assessment period at 2 and 3 months after baseline was conducted with participants who could walk independently. The main outcomes of the main-assessment and sub-assessment periods were Functional Ambulation Classification (FAC) and the 10-m walk test (10MWT), respectively. With respect to the FAC, we used a split plot design analysis of covariance to test the interaction between assessment time and group. There was no significant interaction between assessment time and group in FAC. However, a significant improvement of the 10MWT in the sub-assessment period was observed in the AOT group, but not the control group. Our results indicate that AOT may be an effective therapy for patients with subacute to convalescent stroke who can walk independently.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jocn.2020.03.031
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32234334; ● Search Scopus @ Elsevier (PMID): 32234334; ● Search Scopus @ Elsevier (DOI): 10.1016/j.jocn.2020.03.031

(DOI: 10.1016/j.jocn.2020.03.031, PubMed: 32234334) Yamamoto Yuki, Nobuaki Yamamoto, Koji Fujita, Fukumoto Tatsuya, Murakami Nagahisa, Hideo Mure, Yasuhisa Kanematsu, Yasushi Takagi and Yuishin Izumi :
Cerebral Venous Thrombosis: An Unexpected Complication with Cerebrospinal Fluid Leaks after a Fall in a Patient with Spinocerebellar Ataxia Type 6.,
Internal Medicine, Vol.59, No.14, 1749-1753, 2020.

(徳島大学機関リポジトリ): ● Metadata: 115918
(出版サイトへのリンク): ● Publication site (DOI): 10.2169/internalmedicine.4388-20
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32238726; ● Search Scopus @ Elsevier (PMID): 32238726; ● Search Scopus @ Elsevier (DOI): 10.2169/internalmedicine.4388-20

(徳島大学機関リポジトリ: 115918, DOI: 10.2169/internalmedicine.4388-20, PubMed: 32238726) Nobuaki Yamamoto, Yuki Yamamoto, Izumi Yamaguchi, Manabu Ishihara, Takeshi Miyamoto, Masaaki Korai, Kenji Shimada, Yasuhisa Kanematsu, Yuishin Izumi and Yasushi Takagi :
Cone beam-computed tomography angiography by intravenous contrast injection is reliable to evaluate patients with large vessel occlusion,
Journal of Clinical Neuroscience, Vol.70, 67-71, 2019.

(要約): Mechanical thrombectomy (MT) for acute ischemic stroke (AIS) patients due to emergent large vessel occlusion (ELVO) is standard treatment, the benefits, however, are highly time-sensitive. After patient eligibility for reperfusion therapy is determined by conventional radiological examinations, the time to be transferred from the department of radiological examination to angiography-suites is critical. We speculated that the time required for the diagnosis of AIS might be reduced if we could determine MT eligibility in patients with ELVO at angiography-suites. Modern angiography-suites with flat panel detectors can perform cone beam (CB)-CT. We performed CB-CTA using intravenous injection of contrast agent to evaluate occlusion sites, collateral score, and construction of vessels distal to occlusion sites and determined if CB-CTA could be useful to evaluate patients with ELVO. We included 15 patients with ELVO diagnosed by conventional MRI or CT/CTA, and investigated whether CB-CTA was reliable to diagnose occlusion sites. We also studied if collateral score on CB-CTA was associated with prognosis after successful reperfusion by MT by comparison between favorable (modified Rankin scale (mRS) 0-2), and unfavorable outcome group (mRS 3-6). There was strong agreement of occlusion sites between CB-CTA and conventional radiological examination (κ = 0.80). Collateral score determined by CB-CTA was significantly different between favorable outcome and unfavorable outcome group (median collateral score 2.3 v.s. 1.3, p = 0.040). Although prospective study of AIS patients at a radiography department is indispensable, CB-CTA performed in an angiography-suite might be useful to evaluate patients with ELVO.
(キーワード): Aged / Aged, 80 and over / Brain Ischemia / Carotid Artery Thrombosis / Computed Tomography Angiography / Contrast Media / Female / Humans / Infarction, Middle Cerebral Artery / Injections, Intravenous / Male / Middle Aged / Prognosis / Reperfusion / Retrospective Studies / Thrombectomy / Treatment Outcome
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jocn.2019.08.078
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31445814; ● Summary page in Scopus @ Elsevier: 2-s2.0-85070874852

(DOI: 10.1016/j.jocn.2019.08.078, PubMed: 31445814, Elsevier: Scopus) Izumi Yamaguchi, Yasuhisa Kanematsu, Kenji Shimada, Masaaki Korai, Takeshi Miyamoto, Eiji Shikata, Tadashi Yamaguchi, Nobuaki Yamamoto, Yuki Yamamoto, Keiko Kitazato, Yoshihiro Okayama and Yasushi Takagi :
Active Cancer and Elevated D-Dimer Are Risk Factors for In-Hospital Ischemic Stroke,
Cerebrovascular Diseases Extra, Vol.9, No.3, 129-138, 2019.

(要約): Little attention has been paid to the pathogenesis of in-hospital stroke, despite poor outcomes and a longer time from stroke onset to treatment. We studied the pathophysiology and biomarkers for detecting patients who progress to in-hospital ischemic stroke (IHS). Seventy-nine patients with IHS were sequentially recruited in the period 2011-2017. Their characteristics, care, and outcomes were compared with 933 patients who had an out-of-hospital ischemic stroke (OHS) using a prospectively collected database of the Tokushima University Stroke Registry. Active cancer and coronary artery disease were more prevalent in patients with IHS than in those with OHS (53.2 and 27.8% vs. 2.0 and 10.9%, respectively; p < 0.001), the median onset-to-evaluation time was longer (300 vs. 240 min; p = 0.015), and the undetermined etiology was significantly higher (36.7 vs. 2.4%; p < 0.001). Although there was no significant difference in stroke severity at onset between the groups, patients with IHS had higher modified Rankin Scale (mRS) scores (3-6) at discharge (67.1 vs. 50.3%; p = 0.004) and rates of death during hospitalization (16.5 vs. 2.9%; p < 0.001). D-dimer (5.8 vs. 0.8 µg/mL; p < 0.001) and fibrinogen (532 vs. 430 mg/dL; p = 0.014) plasma levels at the time of onset were significantly higher in patients with IHS after propensity score matching. Multivariate logistic regression analysis revealed that active cancer (odds ratio [OR] 2.30; 95% confidence interval [CI] 1.26-4.20), prestroke mRS scores 3-5 (OR 6.78; 95% CI 3.96-11.61), female sex (OR 1.57; 95% CI 1.19-2.08), and age ≥75 years (OR 2.36; 95% CI 1.80-3.08) were associated with poor outcomes. Patients with IHS had poorer outcomes than those with OHS because of a higher prevalence of active cancer and functional dependence before stroke onset. Elevated plasma levels of D-dimer and fibrinogen, especially with active cancer, can help identify patients who are at a higher risk of progression to IHS.
(キーワード): Aged / Aged, 80 and over / Biomarkers / Brain Ischemia / Databases, Factual / 女性 (female) / Fibrin Fibrinogen Degradation Products / Hospital Mortality / Hospitalization / Humans / Inpatients / 日本 (Japan) / 男性 (male) / Middle Aged / Neoplasms / Prevalence / Prognosis / Registries / Retrospective Studies / Risk Assessment / Risk Factors / Stroke / Time Factors / Up-Regulation
(徳島大学機関リポジトリ): ● Metadata: 115057
(出版サイトへのリンク): ● Publication site (DOI): 10.1159/000504163
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31760390; ● Summary page in Scopus @ Elsevier: 2-s2.0-85075786196

(徳島大学機関リポジトリ: 115057, DOI: 10.1159/000504163, PubMed: 31760390, Elsevier: Scopus) Tanaka Hiroki, Nankaku Manabu, Nishikawa Toru, Yonezawa Honami, Mori Hiroki, Kikuchi Takayuki, Nishi Hidehisa, Yasushi Takagi, Miyamoto Susumu, Ikeguchi Ryosuke and Matsuda Shuichi :
A follow-up study of the effect of training using the Hybrid Assistive Limb on Gait ability in chronic stroke patients.,
Topics in Stroke Rehabilitation, Vol.26, No.7, 491-496, 2019.

(要約): : Recently, use of the Hybrid Assistive Limb (HAL) that is effective for improvement of gait ability in chronic stroke patients has been reported. However, how long the effects are maintained remains unknown. The purpose of the present study was to investigate whether the effect of gait training using the HAL on gait ability was maintained for 3 months after the intervention. : A longitudinal, observational study with an intervention for a single group that adhered to the STROBE guidelines was performed. Nine chronic stroke patients were enrolled in this study. The patients performed gait training sessions using the HAL, 2-5 sessions/week for 3 weeks. Gait speed, stride length, cadence, and 2-minute walk distance (2MWD) were measured before and after intervention and at 3-month follow-up. The clinical trial registration number of this study is UMIN000012764 R000014756. : Compared to the initial status, gait speed ( = .02), stride length ( = .03), cadence ( = .01), and 2MWD ( < .05) were significantly increased immediately after the intervention. Moreover, gait speed ( < .01), cadence ( = .03), and 2MWD ( = .02) remained significantly higher 3 months after the intervention. There were no significant changes in all outcome measures between after intervention and at 3-month follow-up. : This study showed that gait training using the HAL resulted in significant improvement of gait ability after the intervention and the effect was maintained for 3 months after the training.
(出版サイトへのリンク): ● Publication site (DOI): 10.1080/10749357.2019.1640001
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31318323; ● Search Scopus @ Elsevier (PMID): 31318323; ● Search Scopus @ Elsevier (DOI): 10.1080/10749357.2019.1640001

(DOI: 10.1080/10749357.2019.1640001, PubMed: 31318323) Yoshinori Maki, Takayuki Kikuchi, Katsuya Komatsu, Yasushi Takagi and Susumu Miyamoto :
Rare Case of Concurrent Glossopharyngeal and Trigeminal Neuralgia, in Which Glossopharyngeal Neuralgia was Possibly Induced by Postoperative Changes Following Microvascular Decompression for Trigeminal Neuralgia.,
World Neurosurgery, Vol.130, 150-153, 2019.

(要約): Glossopharyngeal neuralgia (GPN) and trigeminal neuralgia (TN) can result from mechanical stimulation of the glossopharyngeal nerve (GPNv) and trigeminal nerve (TNv) by blood vessels. TN can cause severe pain in the orofacial region, whereas GPN manifests as pain in the tongue, throat, tonsil, and ear. Although these 2 neuralgias can occur concurrently, concurrence of recurrent TN and GPN that develops postoperatively has not been previously described. A 68-year-old male complained of right glossalgia and pain in the pharynx radiating to the right auricular area. The patient had previously undergone microvascular decompression (MVD) for right TN. Medication and intraoral xylocaine spray did not relieve the symptoms. An oral surgeon was unable to find any disease related to the glossalgia. The anesthesiologist pointed out that the symptoms could be from partial recurrence of the TN because the patient also complained of pain in the inferior alveolus. Magnetic resonance angiography indicated that the right GPNv seemed to be compressed by the right posterior inferior cerebellar artery (PICA); hence, MVD for both GPN and TN was performed. Intraoperatively, the right PICA was found to be adherent to the GPNv because of the thickened arachnoid membrane and was subsequently detached. The TNv was also examined, but only a Teflon ball was found, which was detached from the TNv. The GPN disappeared postoperatively, although TN persisted after the second operation. GPN can result from adhesions between the GPNv and arachnoid membrane following previous MVD.
(キーワード): Aged / Glossopharyngeal Nerve / Glossopharyngeal Nerve Diseases / Humans / Male / Microvascular Decompression Surgery / Pain / Postoperative Period / Trigeminal Nerve / Trigeminal Neuralgia / Vertebral Artery
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.wneu.2019.06.216
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31295589; ● Search Scopus @ Elsevier (PMID): 31295589; ● Search Scopus @ Elsevier (DOI): 10.1016/j.wneu.2019.06.216

(DOI: 10.1016/j.wneu.2019.06.216, PubMed: 31295589) Tadashi Yamaguchi, Takeshi Miyamoto, keiko Kitazato, Eiji Shikata, Izumi Yamaguchi, Masaaki Korai, Kenji Shimada, Kenji Yagi, Yoshiteru Tada, Yoshihito Matsuzaki, Yasuhisa Kanematsu and Yasushi Takagi :
Time-dependent and site-dependent morphological changes in rupture-prone arteries: ovariectomized rat intracranial aneurysm model,
Journal of Neurosurgery, 2019.

(要約): The pathogenesis of intracranial aneurysm rupture remains unclear. Because it is difficult to study the time course of human aneurysms and most unruptured aneurysms are stable, animal models are used to investigate the characteristics of intracranial aneurysms. The authors have newly established a rat intracranial aneurysm rupture model that features site-specific ruptured and unruptured aneurysms. In the present study the authors examined the time course of changes in the vascular morphology to clarify the mechanisms leading to rupture. Ten-week-old female Sprague-Dawley rats were subjected to hemodynamic changes, hypertension, and ovariectomy. Morphological changes in rupture-prone intracranial arteries were examined under a scanning electron microscope and the association with vascular degradation molecules was investigated. At 2-6 weeks after aneurysm induction, morphological changes and rupture were mainly observed at the posterior cerebral artery; at 7-12 weeks they were seen at the anterior Willis circle including the anterior communicating artery. No aneurysms at the anterior cerebral artery-olfactory artery bifurcation ruptured, suggesting that the inception of morphological changes is site dependent. On week 6, the messenger RNA level of matrix metalloproteinase-9, interleukin-1β, and the ratio of matrix metalloproteinase-9 to the tissue inhibitor of metalloproteinase-2 was significantly higher at the posterior cerebral artery, but not at the anterior communicating artery, of rats with aneurysms than in sham-operated rats. These findings suggest that aneurysm rupture is attributable to significant morphological changes and an increase in degradation molecules. Time-dependent and site-dependent morphological changes and the level of degradation molecules may be indicative of the vulnerability of aneurysms to rupture.
(徳島大学機関リポジトリ): ● Metadata: 113804
(出版サイトへのリンク): ● Publication site (DOI): 10.3171/2019.6.JNS19777
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31518986; ● Search Scopus @ Elsevier (PMID): 31518986; ● Search Scopus @ Elsevier (DOI): 10.3171/2019.6.JNS19777

(徳島大学機関リポジトリ: 113804, DOI: 10.3171/2019.6.JNS19777, PubMed: 31518986) Eiji Shikata, Tetsuya Tamura, Kiyohito Shinno, Yoshihiro Okayama, Naoki Shinohara, Kenji Shimada, Yasuhisa Kanematsu, Keiko T Kitazato, Shinji Nagahiro and Yasushi Takagi :
Importance of Managing the Water-Electrolyte Balance by Delivering the Optimal Minimum Amount of Water and Sodium After Subarachnoid Hemorrhage.,
World Neurosurgery, Vol.129, e352-e360, 2019.

(要約): After aneurysmal subarachnoid hemorrhage (aSAH), crystalloid fluids with a relatively high sodium concentration have been used to maintain the cerebral blood flow. However, the prophylactic delivery of water and sodium by intravenous (IV) infusion will not necessarily improve the prognosis of patients after aSAH, and the excessive supply of water and sodium can negatively affect the outcome. We hypothesized that the delivery of an optimal amount of water and sodium separately might improve the outcome after aSAH. We recruited 55 consecutive patients who had undergone clipping or endovascular coil embolization after aSAH. Group 1 (n = 33) received conventional therapy (i.e., prophylactic IV sodium and water [protocol 1]). Group 2 (n = 22) received the optimal amount of water and sodium separately (protocol 2). The median total of water and sodium chloride supplied in group 1 was significantly greater than that supplied in group 2 (P < 0.01). The modified Rankin scale score at discharge was 0-2 in 15 patients (95%) in group 2 and 23 patients (55%) in group 1 (P < 0.001). On multivariate logistic regression analysis, the odds ratio for a discharge modified Rankin scale score of 0-2 or 3-6 was significantly associated with the treatment protocol (P < 0.05) and the net fluid balance on days 4-8 (P < 0.05). The separate delivery of optimal amounts of water and sodium could be a promising therapeutic strategy to improve the prognosis after aSAH.
(キーワード): Administration, Intravenous / Aged / Embolization, Therapeutic / Female / Fluid Therapy / Humans / Male / Middle Aged / Postoperative Care / Retrospective Studies / Subarachnoid Hemorrhage / Treatment Outcome / Water-Electrolyte Balance
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.wneu.2019.05.152
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31132492; ● Search Scopus @ Elsevier (PMID): 31132492; ● Search Scopus @ Elsevier (DOI): 10.1016/j.wneu.2019.05.152

(DOI: 10.1016/j.wneu.2019.05.152, PubMed: 31132492) Hermanto Yulius, Takakuni Maki, Yasushi Takagi, Susumu Miyamoto and Jun Takahashi :
Xeno-free culture for generation of forebrain oligodendrocyte precursor cells from human pluripotent stem cells,
Journal of Neuroscience Research, Vol.97, No.7, 828-845, 2019.

(要約): Oligodendrocytes (OLs) show heterogeneous properties that depend on their location in the central nervous system (CNS). In this regard, the investigation of oligodendrocyte precursor cells (OPCs) derived from human pluripotent stem cells (hPSCs) should be reconsidered, particularly in cases of brain-predominant disorders for which brain-derived OPCs are more appropriate than spinal cord-derived OPCs. Furthermore, animal-derived components are responsible for culture variability in the derivation and complicate clinical translation. In the present study, we established a xeno-free system to induce forebrain OPCs from hPSCs. We induced human forebrain neural stem cells (NSCs) on Laminin 511-E8 and directed the differentiation to the developmental pathway for forebrain OLs with SHH and FGF signaling. OPCs were characterized by the expression of OLIG2, NKX2.2, SOX10, and PDGFRA, and subsequent maturation into O4 cells. In vitro characterization showed that >85% of the forebrain OPCs (O4 ) underwent maturation into OLs (MBP ) 3 weeks after mitogen removal. Upon intracranial transplantation, the OPCs survived, dispersed in the corpus callosum, and matured into (GSTϖ ) OLs in the host brains 3 months after transplantation. These findings suggest our xeno-free induction of forebrain OPCs from hPSCs could accelerate clinical translation for brain-specific disorders.
(出版サイトへのリンク): ● Publication site (DOI): 10.1002/jnr.24413
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30891830; ● Search Scopus @ Elsevier (PMID): 30891830; ● Search Scopus @ Elsevier (DOI): 10.1002/jnr.24413

(DOI: 10.1002/jnr.24413, PubMed: 30891830) Toshiyuki Okazaki, Yasuhisa Kanematsu, Kenji Shimada, Masaaki Korai, Junichiro Satomi, Masaaki Uno, Shinji Nagahiro and Yasushi Takagi :
A Single-center Retrospective Study with 5- and 10-year Follow-up of Carotid Endarterectomy with Patch Graft.,
Neurologia Medico-Chirurgica, Vol.59, No.6, 231-237, 2019.

(要約): Carotid endarterectomy (CEA) is widely used for cervical artery stenosis. In Japan, primary closure after endarterectomy has been a standard technique. Recently, the patch closure has been shown to be superior to the primary suture for the prevention of restenosis and ipsilateral stroke. This study evaluated the 5- and 10-year outcomes following CEA with patch graft closure in our institution. Between January 2000 and March 2013, 134 patients, who underwent CEA with patch graft closure were investigated in the current retrospective study. Among these patients, 102 CEAs in 97 patients were followed up for 5 years and 66 CEAs in 61 patients were for 10 years after the procedure. Restenosis was defined as >50% recurrent luminal narrowing at the endarterectomy site. In 5 years, symptomatic restenosis exhibited minor stroke in one patient at 58 months after CEA (restenosis rate 1.0%). The ipsilateral minor stroke occurred in three patients including the above case (2.9%). In 10 years, asymptomatic restenosis occurred in three patients in addition to the above symptomatic case (restenosis rate 6.1%), and the ipsilateral minor stroke occurred in four patients (6.1%). Carotid endarterectomy with patch graft exerted a high protective effect from restenosis up to 5 and 10 years in our institution. The number of carotid artery stenting is increasing all over the world but we speculated that the established surgical procedure of patched CEA prevented restenosis and ipsilateral stroke.
(キーワード): Aged / Blood Vessel Prosthesis Implantation / Carotid Stenosis / Endarterectomy, Carotid / Female / Follow-Up Studies / Graft Occlusion, Vascular / Humans / Male / Middle Aged / Postoperative Complications / Retrospective Studies / Stents / Stroke / Time Factors
(徳島大学機関リポジトリ): ● Metadata: 119185
(出版サイトへのリンク): ● Publication site (DOI): 10.2176/nmc.oa.2018-0309
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31061257; ● Search Scopus @ Elsevier (PMID): 31061257; ● Search Scopus @ Elsevier (DOI): 10.2176/nmc.oa.2018-0309

(徳島大学機関リポジトリ: 119185, DOI: 10.2176/nmc.oa.2018-0309, PubMed: 31061257) Mieko Oka, Mika Kushamae, Tomohiro Aoki, Tadashi Yamaguchi, Keiko Kitazato, Yu Abekura, Takakazu Kawamata, Tohru Mizutani, Miyamoto Susumu and Yasushi Takagi :
KRAS G12D or G12V Mutation in Human Brain Arteriovenous Malformations,
World Neurosurgery, Vol.126, e1365-e1373, 2019.

(要約): Brain arteriovenous malformations (BAVMs) are vascular malformations composed of tangles of abnormally developed vasculature without capillaries. Abnormal shunting of arteries and veins is formed, resulting in high-pressure vascular channels, which potentially lead to rupture. BAVMs are generally considered a congenital disorder. But clinical evidence regarding involution, regrowth, and de novo formation argue against the static condition of this disease. Recently, the presence of the somatic activating KRAS mutations in more than half of BAVM cases was reported, suggesting the role of KRAS function in the pathogenesis. KRAS mutation in codon35 (G→A, G12D; G→T, G12V) was examined by a digital polymerase chain reaction analysis using genome purified from paraffin-embedded slides of human BAVMs. We also examined protein expression of KRAS G12D in lesions to corroborate results from digital polymerase chain reaction analysis. We detected codon35 G→A mutation in 15 (39.5%) among 38 samples and codon35 G→T mutation in 10 (27.0%) among 37 samples we could assess mutations. There were no samples positive for both codon35 G→A and G→T mutation. The ratio of codon35 G→A mutation ranged from 0.60% to 12.28% and that of G→T was from 1.20% to 8.99%. We next examined protein expression of KRAS G12D in BAVM lesions in immunohistochemistry. A KRAS G12D mutant was detected mainly in endothelial cells of dilated vessels in lesions. KRAS mutations in codon35 were detected in about two thirds of specimens examined. KRAS function may actively contribute to the pathobiology of BAVM and can become a therapeutic target.
(キーワード): Adult / Arteriovenous Fistula / Child / Female / Genetic Predisposition to Disease / Humans / Intracranial Arteriovenous Malformations / Male / Point Mutation / Proto-Oncogene Proteins p21(ras)
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.wneu.2019.03.105
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30902772; ● Search Scopus @ Elsevier (PMID): 30902772; ● Search Scopus @ Elsevier (DOI): 10.1016/j.wneu.2019.03.105

(DOI: 10.1016/j.wneu.2019.03.105, PubMed: 30902772) Natsue Kishida, Takakuni Maki, Yasushi Takagi, Ken Yasuda, Hisanori Kinoshita, Takashi Ayaki, Takayuki Noro, Yusuke Kinoshita, Yuichi Ono, Hiroharu Kataoka, Kazumichi Yoshida, Eng H. Lo, Ken Arai, Susumu Miyamoto and Ryosuke Takahashi :
Role of Perivascular Oligodendrocyte Precursor Cells in Angiogenesis After Brain Ischemia.,
Journal of the American Heart Association, Vol.8, No.9, e011824, 2019.

(要約): Background Oligodendrocyte precursor cells ( OPC s) regulate neuronal, glial, and vascular systems in diverse ways and display phenotypic heterogeneity beyond their established role as a reservoir for mature oligodendrocytes. However, the detailed phenotypic changes of OPC s after cerebral ischemia remain largely unknown. Here, we aimed to investigate the roles of reactive OPC s in the ischemic brain. Methods and Results The behavior of OPC s was evaluated in a mouse model of ischemic stroke produced by transient middle cerebral artery occlusion in vivo. For in vitro experiments, the phenotypic change of OPC s after oxygen glucose derivation was examined using a primary rat OPC culture. Furthermore, the therapeutic potential of hypoxic OPC s was evaluated in a mouse model of middle cerebral artery occlusion in vivo. Perivascular OPC s in the cerebral cortex were increased alongside poststroke angiogenesis in a mouse model of middle cerebral artery occlusion. In vitro RNA -seq analysis revealed that primary cultured OPC s increased the gene expression of numerous pro-angiogenic factors after oxygen glucose derivation. Hypoxic OPC s secreted a greater amount of pro-angiogenic factors, such as vascular endothelial growth factor and angiopoietin-1, compared with normoxic OPC s. Hypoxic OPC -derived conditioned media increased the viability and tube formation of endothelial cells. In vivo studies also demonstrated that 5 consecutive daily treatments with hypoxic OPC -conditioned media, beginning 2 days after middle cerebral artery occlusion, facilitated poststroke angiogenesis, alleviated infarct volume, and improved functional disabilities. Conclusions Following cerebral ischemia, the phenotype of OPC s in the cerebral cortex shifts from the parenchymal subtype to the perivascular subtype, which can promote angiogenesis. The optimal use of hypoxic OPC s secretome would provide a novel therapeutic option for stroke.
(徳島大学機関リポジトリ): ● Metadata: 115571
(出版サイトへのリンク): ● Publication site (DOI): 10.1161/JAHA.118.011824
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31020902; ● Summary page in Scopus @ Elsevier: 2-s2.0-85065291909

(徳島大学機関リポジトリ: 115571, DOI: 10.1161/JAHA.118.011824, PubMed: 31020902, Elsevier: Scopus) Akinori Miyakoshi, Takeshi Funaki, C Jun Takahashi, Yasushi Takagi, Takayuki Kikuchi, Kazumichi Yoshida, Hiroharu Kataoka, Yohei Mineharu, Masakazu Okawa, Yukihiro Yamao, Yasutaka Fushimi, Tomohisa Okada, Kaori Togashi and Susumu Miyamoto :
Restoration of Periventricular Vasculature After Direct Bypass for Moyamoya Disease: Intra-Individual Comparison,
Acta Neurochirurgica, Vol.161, No.5, 947-954, 2019.

(要約): While periventricular anastomosis, a unique abnormal vasculature in moyamoya disease, has been studied in relation to intracranial hemorrhage, no study has addressed its change after bypass surgery. The authors sought to test whether direct bypass surgery could restore normal periventricular vasculature. Patients who had undergone direct bypass surgery for moyamoya disease at a single institution were eligible for the study. Baseline, postoperative, and follow-up magnetic resonance angiography (MRA) scans were scheduled before surgery, after the first surgery, and 3 to 6 months after contralateral second surgery, respectively. Sliding-thin-slab maximum-intensity-projection coronal MRA images of periventricular anastomoses were scored according to the three subtypes (lenticulostriate, thalamic, and choroidal anastomosis). Baseline and postoperative MRA images were compared to obtain a matched comparison of score changes in the surgical and nonsurgical hemispheres within individuals (intra-individual comparison). Of 110 patients, 42 were identified for intra-individual comparisons. The periventricular anastomosis score decreased significantly in the surgical hemispheres (median, 2 versus 1; p < 0.001), whereas the score remained unchanged in the nonsurgical hemispheres (median, 2 versus 2; p = 0.57); the score change varied significantly between the surgical and nonsurgical hemispheres (p < 0.001). Of the 104 periventricular-anastomosis-positive hemispheres undergoing surgery, 47 (45.2%) were assessed as negative in the follow-up MRA. Among the subtypes, choroidal anastomosis was most likely to be assessed as negative (79.7% of positive hemispheres). Periventricular vasculature can be restored after direct bypass. The likelihood of correction of choroidal anastomosis is a subject requiring further studies.
(キーワード): Adult / Anastomosis, Surgical / Cerebral Revascularization / Female / Humans / Magnetic Resonance Angiography / Male / Middle Aged / Moyamoya Disease / Postoperative Complications
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s00701-019-03866-9
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30880348; ● Summary page in Scopus @ Elsevier: 2-s2.0-85063028221

(DOI: 10.1007/s00701-019-03866-9, PubMed: 30880348, Elsevier: Scopus) Toshihiro Munemitsu, Akira Ishii, Eiji Okada, Hideo Chihara, Kazumichi Yoshida, Jun C Takahashi, Yasushi Takagi and Susumu Miyamoto :
Ex Vivo Assessment of Various Histological Differentiation in Human Carotid Plaque with Near-infrared Spectroscopy Using Multiple Wavelengths.,
Neurologia Medico-Chirurgica, Vol.59, No.5, 163-171, 2019.

(要約): We previously reported that near-infrared hyperspectral imaging enabled the localization of atherosclerotic plaques from outside the vessels, but not the optical characteristics of each histological component. Therefore, the near-infrared spectrum of each component was collected from the sliced section of the human carotid plaque obtained with endarterectomy and the optical characteristics were confirmed in several wavelengths. Based on this information, we assessed the diagnostic accuracy for ex vivo chemogram in each plaque component created with near-infrared spectroscopy (NIRS), using multiple wavelengths. The chemogram projected on the actual image of plaque was created based on light intensity and transmittance change at three wavelengths. The wavelengths that were mainly were 1440, 1620, 1730, and 1930 nm. We evaluated the accuracy of histological diagnosis in chemogram compared with pathological findings, analyzing interobserver agreement with κ-statistics. The chemograms that we created depicted the components of fibrous tissue, smooth muscle, lipid tissue, intraplaque hemorrhage, and calcification. Diagnostic odds ratio in each component was as follows: 259.6 in fibrous tissue, 144 in smooth muscle, 1123.5 in lipid tissue, 29.3 in intraplaque hemorrhage, and 136.3 in calcification. The κ-statistics revealed that four components, excluding intraplaque hemorrhage, had substantial or almost perfect agreement. Thus, this study demonstrated the feasibility of using chemogram focused on specific component during the histological assessment of atherosclerotic plaques, highlighting its potential diagnostic ability. Chemograms of various target components can be created by combining multiple wavelengths. This technology may prove to be useful in improving the histological assessment of plaque using NIRS.
(キーワード): Carotid Artery Diseases / Endarterectomy, Carotid / Humans / Observer Variation / Odds Ratio / Plaque, Atherosclerotic / Reproducibility of Results / Sensitivity and Specificity / Spectroscopy, Near-Infrared / Tissue Culture Techniques
(徳島大学機関リポジトリ): ● Metadata: 119186
(出版サイトへのリンク): ● Publication site (DOI): 10.2176/nmc.oa.2018-0203
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30814423; ● Search Scopus @ Elsevier (PMID): 30814423; ● Search Scopus @ Elsevier (DOI): 10.2176/nmc.oa.2018-0203

(徳島大学機関リポジトリ: 119186, DOI: 10.2176/nmc.oa.2018-0203, PubMed: 30814423) Yamamoto Yuki, Nobuaki Yamamoto, Yasuhisa Kanematsu, Masaaki Korai, Kenji Shimada, Yuishin Izumi and Yasushi Takagi :
The Claw Sign: An angiographic Predictor of Recanalization After Mechanical Thrombectomy for Cerebral Large Vessel Occlusion.,
Journal of Stroke & Cerebrovascular Diseases, Vol.28, No.6, 1555-1560, 2019.

(要約): Mechanical thrombectomy undoubtedly improves functional outcomes for patients with acute ischemic stroke. Although we have observed occlusion sites that protrude proximally into the vessel on angiography, termed the "claw sign," we have been unable to state its clinical significance. In this study, we aimed to determine whether the presence of a claw sign was related to recanalization success after mechanical thrombectomy. We retrospectively included 73 consecutive patients treated for acute cerebral large vessel occlusion by mechanical thrombectomy between January 2014 and December 2017. The angiographic claw sign was defined as a thrombus that protruded proximally by more than half the diameter of the parent artery. Claw sign positivity, clinical and etiological features, and outcomes were compared between groups with and without recanalization. The claw sign was observed in 29 of 73 (40%) patients and was positive significantly more frequently in those with recanalization (50.0%) than in those without recanalization (5.9%) (P < .01). By multivariate analysis, the claw sign was the only pretreatment parameter to predict successful recanalization (odds ratio, 12.50; 95% confidence interval, 1.50-103.00; P = .019). The presence of the claw sign might predict successful recanalization in patients undergoing mechanical thrombectomy for large vessel occlusion.
(キーワード): Aged / Aged, 80 and over / Angiography, Digital Subtraction / Cerebral Angiography / Cerebral Arteries / Cerebrovascular Circulation / Constriction, Pathologic / Female / Humans / Intracranial Thrombosis / Male / Middle Aged / Predictive Value of Tests / Retrospective Studies / Thrombectomy / Thrombolytic Therapy / Treatment Outcome / Vascular Patency
(徳島大学機関リポジトリ): ● Metadata: 114639
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jstrokecerebrovasdis.2019.03.007
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30930237; ● Search Scopus @ Elsevier (PMID): 30930237; ● Search Scopus @ Elsevier (DOI): 10.1016/j.jstrokecerebrovasdis.2019.03.007

(徳島大学機関リポジトリ: 114639, DOI: 10.1016/j.jstrokecerebrovasdis.2019.03.007, PubMed: 30930237) Akemi Hioka, Yoshiteru Tada, Keiko Kitazato, Yasuhisa Kanematsu, Yoshifumi Mizobuchi, Hideo Mure, Kenji Shimada, Toshiyuki Okazaki, Masaaki Korai, Noki Akazawa, Yuki Matsumoto, Yuki Matsumoto, Yasushi Takagi and Shinji Nagahiro :
Activation of mirror neuron system during gait observation in sub-acute stroke patients and healthy persons.,
Journal of Clinical Neuroscience, Vol.60, 79-83, 2019.

(要約): The observation of walking improves gait ability in chronic stroke survivors. It has also been suggested that activation of the mirror neuron system contributes to this effect. However, activation of the mirror neuron system during gait observation has not yet been assessed in sub-acute stroke patients. The objective of this study was to clarify the activation of mirror neuron system during gait observation in sub-acute stroke patients and healthy persons. In this study, we sequentially enrolled five sub-acute stroke patients who had undergone gait training and nine healthy persons. We used fMRI to detect neuronal activation during gait observation. During the observation period in the stroke group, neural activity in the left inferior parietal lobule, right and left inferior frontal gyrus was significantly higher than during the rest period. In the healthy group, neural activity in the left inferior parietal lobule, left inferior frontal gyrus, left middle frontal gyrus, left superior temporal lobule and right and left middle temporal gyrus was significantly higher than during the rest period. The results indicate that the mirror neuron system was activated during gait observation in sub-acute stroke patients who had undergone gait training and also in healthy persons. Our findings suggest that gait observation treatment may provide a promising therapeutic strategy in sub-acute stroke patients who have experienced gait training.
(キーワード): Adult / Brain / Exercise Therapy / Female / Gait / Humans / Magnetic Resonance Imaging / Male / Middle Aged / Mirror Neurons / Stroke / Stroke Rehabilitation
(徳島大学機関リポジトリ): ● Metadata: 113267
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jocn.2018.09.035
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30318398; ● Search Scopus @ Elsevier (PMID): 30318398; ● Search Scopus @ Elsevier (DOI): 10.1016/j.jocn.2018.09.035

(徳島大学機関リポジトリ: 113267, DOI: 10.1016/j.jocn.2018.09.035, PubMed: 30318398) Nobuaki Yamamoto, Yuki Yamamoto, Masaaki Korai, Kenji Shimada, Yasuhisa Kanematsu, Yuishin Izumi, Junichiro Satomi, Yasushi Takagi and Ryuji Kaji :
Simultaneous approach to tandem occlusion in acute ischemic stroke patients: Percutaneous Transluminal Angioplasty (PTA) using push wire of stent retriever,
Journal of Neuroendovascular Therapy, Vol.13, No.6, 257-261, 2019.

(出版サイトへのリンク): ● Publication site (DOI): 10.5797/jnet.cr.2018-0108
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390001288147947776; ● Search Scopus @ Elsevier (DOI): 10.5797/jnet.cr.2018-0108

(DOI: 10.5797/jnet.cr.2018-0108, CiNii: 1390001288147947776) Hiroshi Kagusa, Yoshifumi Mizobuchi, Kohhei Nakajima, Toshitaka Fujihara, Yoshimi Bando and Yasushi Takagi :
Metastatic tumor to the orbital cavity from a primary carcinoma of the uterine cervix : a case report.,
The Journal of Medical Investigation : JMI, Vol.66, No.3,4, 355-357, 2019.

(要約): Metastatic tumors to the orbit of the eye, especially from primary carcinomas of the uterine cervix are very rare. A 64-year-old woman with a history of carcinoma of the uterine cervix presented with right eye pain and blepharoptosis for 2 weeks. Magnetic resonance imaging revealed a mass at the right orbital apex. Surgical extirpation was performed due to severe pain. Postoperative pathology demonstrated a poorly differentiated squamous cell carcinoma. The origin was ultimately considered to be the carcinoma of the uterine cervix. In conclusion, this report describes a rare case of a metastatic tumor at the orbital apex derived from the cervix of the uterus. J. Med. Invest. 66 : 355-357, August, 2019.
(徳島大学機関リポジトリ): ● Metadata: 114169
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.66.355
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31656305; ● Search Scopus @ Elsevier (PMID): 31656305; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.66.355

(徳島大学機関リポジトリ: 114169, DOI: 10.2152/jmi.66.355, PubMed: 31656305) Yoshifumi Mizobuchi, Kohhei Nakajima, Toshitaka Fujihara, Kazuhito Matsuzaki, Hideo Mure, Shinji Nagahiro and Yasushi Takagi :
The risk of hemorrhage in stereotactic biopsy for brain tumors.,
The Journal of Medical Investigation : JMI, Vol.66, No.3,4, 314-318, 2019.

(要約): Objective : One major complication associated with STB is intratumoral hematoma, which is also the most common cause of morbidity related to permanent paralysis and mortality in STB. The risk of perioperative hemorrhage is generally between 1% and 10%, but this could be an underestimation since it is not common for many neurosurgeons to perform CT scans after uncomplicated STBs. In this study, we describe the incidence of cerebral hemorrhage, including asymptomatic cerebral hemorrhage. Methods : We recently reviewed data on the diagnosis rate and occurrence of complications, including symptomatic and asymptomatic cerebral hemorrhage, in 80 patients who underwent STB at our facility between 2005 and 2014. Results : Histological diagnosis was established for 75 cases (93.8%), glioma was the most frequently encountered tumor. Symptomatic hemorrhage was observed in two cases (2.6%), with the symptoms subsiding within two days. The morbidity and mortality rate was 0%. However, asymptomatic hemorrhages were observed in 23 cases (28.8%). Conclusion : Stereotactic biopsy is a less invasive procedure for obtaining samples of brain tumors for diagnosis. The bleeding of the tissue-resection cavity that includes asymptomatic hemorrhage occurs at a constant rate. It is important to reduce the symptomatic bleeding associated with stereotactic biopsy. J. Med. Invest. 66 : 314-318, August, 2019.
(キーワード): Adolescent / Adult / Aged / Aged, 80 and over / Biopsy / Brain / Brain Neoplasms / Cerebral Hemorrhage / Female / Humans / Male / Middle Aged / Stereotaxic Techniques / Young Adult
(徳島大学機関リポジトリ): ● Metadata: 114088
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.66.314
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31656296; ● Search Scopus @ Elsevier (PMID): 31656296; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.66.314

(徳島大学機関リポジトリ: 114088, DOI: 10.2152/jmi.66.314, PubMed: 31656296) K Komatsu, Yasushi Takagi, T Kikuchi, Y Yamao, Y Fushimi, J Grinstead, S Ahn and S Miyamoto :
Ruptured intranidal aneurysm of an arteriovenous malformation diagnosed by delay alternating with nutation for tailored excitation (DANTE)-prepared contrast-enhanced magnetic resonance imaging,
Acta Neurochirurgica, Vol.160, No.12, 2435-2438, 2018.

(要約): This case report describes the usefulness of delay alternating with nutation for tailored excitation (DANTE)-prepared, contrast-enhanced magnetic resonance imaging (CE-MRI) for detecting the rupture site of an arteriovenous malformation (AVM). A ruptured intranidal aneurysm was confirmed histopathologically. Accurate non-invasive information about the possible rupture site of an AVM is critical for optimal treatment and evaluation. Vessel wall enhancement visualized by DANTE-prepared CE-MRI may be a useful tool for providing information about changes in inflammatory status and vulnerability to further developments.
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s00701-018-3713-7
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30367252; ● Summary page in Scopus @ Elsevier: 2-s2.0-85055887945

(DOI: 10.1007/s00701-018-3713-7, PubMed: 30367252, Elsevier: Scopus) Toshiyuki Okazaki, H Nakagawa, Hideo Mure, Kenji Yagi, H Hayase, Yasushi Takagi and K Saito :
Microdiscectomy and Foraminotomy in Cervical Spondylotic Myelopathy and Radiculopathy,
Neurologia Medico-Chirurgica, Vol.58, No.11, 468-476, 2018.

(要約): This study was to assess the efficacy of microdiscectomy, cage fixation, and right tranuncal foramintomy for the patients suffering from right radiulo-myelopathy. Anterior cervical foraminotomy was reported to be an effective option for the treatment of cervical degenerative radiculopathy but with the problem of recurrence. Since Hakuba reported the method of trans-unco-discal approach in 1976, it was designed as keyhole foraminotomy which was called transuncal approach, transpedicular approach or transvertebral approach. In the anterior approach, we usually use the right-sided approach because most of us are right-handed surgeons. We retrospectively investigated our patients who had the right foraminal stenosis causing radiculopathy and were treated with microdiscectomy, cage fixation, and right keyhole transuncal foraminotomy. Since 2011, 23 patients were treated with the manner. All of the 23 patients who had central canal stenosis and among the 23 patients, 8 patients showed only right radiculopathy and 15 patients showed radiculo-myelopathy. In all patients, the radiculopathy disappeared or significantly improved without any complications postoperatively. The average of VAS scores was 7.6 ± 2.2 in preoperative state, 2.8 ± 2.2 at discharge, and 1.1 ± 1.6 in 1 month after surgery. The average of follow-up time was 38.3 months and they had no recurrence of radiculopathy. We showed that this manner is effective and one option for the combined disease of right foraminal and canal stenosis and we believe that this manner is not complex and safe if we can understand the anatomy.
(キーワード): Adult / Aged / Diskectomy / Female / Foraminotomy / Humans / Male / Middle Aged / Radiculopathy / Retrospective Studies / Spinal Cord Diseases / Spinal Stenosis / Spondylosis / Treatment Outcome
(徳島大学機関リポジトリ): ● Metadata: 119193
(出版サイトへのリンク): ● Publication site (DOI): 10.2176/nmc.oa.2018-0077
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30298831; ● Search Scopus @ Elsevier (PMID): 30298831; ● Search Scopus @ Elsevier (DOI): 10.2176/nmc.oa.2018-0077

(徳島大学機関リポジトリ: 119193, DOI: 10.2176/nmc.oa.2018-0077, PubMed: 30298831) 溝渕佳史, 髙木康志, 永廣信治 :
脳震盪の病態と最近の話題,
Clinical Neuroscience, Vol.36, No.10, 1128-1131, 2018年. N Enomoto, Hideo Mure, Toshiyuki Okazaki, M Azumi, S Okita, Shinji Nagahiro and Yasushi Takagi :
Posttraumatic Cerebrospinal Fluid Leak Associated with an Upper Cervical Meningeal Diverticulum,
World Neurosurgery, Vol.116, 50-55, 2018.

(要約): Spontaneous intracranial hypotension (SIH) has been increasingly recognized as a phenomenon caused by cerebrospinal fluid (CSF) leaks; however, its pathogenesis remains unclear. We report 2 cases of SIH resulting from CSF leak from a meningeal diverticulum at the C2 nerve root sleeve. The first case is that of a 46-year-old man who experienced orthostatic headache after a bicycle accident at age 45. Computed tomography (CT) myelography revealed CSF leaks at the C1-2 level. He underwent epidural blood patch therapy, but it was unsuccessful. Next, we performed direct surgery and found a meningeal diverticulum originating from the left C2 nerve root; therefore, we ligated the diverticulum. His symptoms and image findings strikingly improved after surgery. The second case is that of a 45-year-old man who experienced orthostatic headache 1 month after jumping into a river. Magnetic resonance imaging of the head showed bilateral subdural hematoma. CT myelography revealed CSF leaks at the C1-2 level and multiple cyst formations at the cervical and thoracic nerve root sleeves. epidural blood patch was performed, and his symptoms immediately improved. Recent studies have reported that meningeal diverticulum is involved in various cases of CSF leaks. The 2 cases indicate that traumatic accidents, such as back-and-forth neck movement or falls, presumably induce an increase in CSF pressure, followed by the rupture of an existing meningeal diverticulum, leading to CSF leak.
(キーワード): Blood Patch, Epidural / Brain Injuries, Traumatic / Cerebrospinal Fluid Leak / Cervical Vertebrae / Diverticulum / Humans / Male / Meninges / Middle Aged
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.wneu.2018.05.061
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29777885; ● Summary page in Scopus @ Elsevier: 2-s2.0-85047768412

(DOI: 10.1016/j.wneu.2018.05.061, PubMed: 29777885, Elsevier: Scopus) 高麗雅章, 溝渕佳史, 髙木康志, 永廣信治 :
スポーツ頭部外傷の基礎知識,
作業療法ジャーナル, Vol.52, No.7, 646-650, 2018年.

(出版サイトへのリンク): ● Publication site (DOI): 10.11477/mf.5001201344
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.11477/mf.5001201344

(DOI: 10.11477/mf.5001201344) 高麗雅章, 里見淳一郎, 髙木康志 :
硬膜動静脈瘻に対する直達術,
脳神経外科速報, Vol.28, No.7, 678-683, 2018年. Yasuhisa Kanematsu, Junichiro Satomi, Masaaki Korai, Toshiyuki Okazaki, Idumi Yamaguchi, Yoshiteru Tada, Masaaki Uno, Shinji Nagahiro and Yasushi Takagi :
Flow Alteration Therapy for Ruptured Vertebral Artery Dissecting Aneurysms Involving the Posterior Inferior Cerebellar Artery,
Neurologia Medico-Chirurgica, Vol.58, 341-349, 2018.

(要約): Surgery for- and endovascular treatment of vertebral artery (VA) dissecting aneurysms involving the origin of the posterior inferior cerebellar artery (PICA) remain challenging. Their ideal treatment is complete isolation of the aneurysm by surgical or endovascular trapping plus PICA reconstruction. However, postoperative lower cranial nerve palsy and medullary infarction are potential complications. We report four patients with VA dissecting aneurysms involving the PICA origin who were treated by occipital artery (OA)-PICA bypass followed by proximal occlusion of the VA and clip ligation of the PICA origin instead of trapping. There were no procedural or ischemic complications. In all patients, angiography performed 2-3 weeks later showed good patency of the bypass graft and complete obliteration of the aneurysm. During the follow-up period ranging from 1 to 14 years, none experienced bleeding. Although retrograde blood flow to the dissecting aneurysm persisted in the absence of trapping, iatrogenic lower cranial nerve injury could be avoided. The decrease in aneurysmal flow might elicit spontaneous thrombosis and prevent aneurysmal rerupture. Our technique might be less invasive than aneurysmal trapping and help to prevent rebleeding.
(徳島大学機関リポジトリ): ● Metadata: 119189
(出版サイトへのリンク): ● Publication site (DOI): 10.2176/nmc.oa.2018-0076
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29998934; ● Summary page in Scopus @ Elsevier: 2-s2.0-85051865821

(徳島大学機関リポジトリ: 119189, DOI: 10.2176/nmc.oa.2018-0076, PubMed: 29998934, Elsevier: Scopus) Toshitaka Fujihara, Yoshifumi Mizobuchi, Kohhei Nakajima, Teruyoshi Kageji, Kazuhito Matsuzaki, KT Kitazato, Ryotaro Otsuka, Keijiro Hara, Hideo Mure, Toshiyuki Okazaki, Kazuyuki Kuwayama, Shinji Nagahiro and Yasushi Takagi :
Down-regulation of MDR1 by Ad-DKK3 via Akt/NFB pathways augments the anti-tumor effect of temozolomide in glioblastoma cells and a murine xenograft model,
Journal of Neuro-Oncology, Vol.139, No.2, 323-332, 2018.

(要約): Glioblastoma multiforme (GBM) is the most malignant of brain tumors. Acquired drug resistance is a major obstacle for successful treatment. Earlier studies reported that expression of the multiple drug resistance gene (MDR1) is regulated by YB-1 or NFκB via the JNK/c-Jun or Akt pathway. Over-expression of the Dickkopf (DKK) family member DKK3 by an adenovirus vector carrying DKK3 (Ad-DKK3) exerted anti-tumor effects and led to the activation of the JNK/c-Jun pathway. We investigated whether Ad-DKK3 augments the anti-tumor effect of temozolomide (TMZ) via the regulation of MDR1. GBM cells (U87MG and U251MG), primary TGB105 cells, and mice xenografted with U87MG cells were treated with Ad-DKK3 or TMZ alone or in combination. Ad-DKK3 augmentation of the anti-tumor effects of TMZ was associated with reduced MDR1 expression in both in vivo and in vitro studies. The survival of Ad-DKK3-treated U87MG cells was inhibited and the expression of MDR1 was reduced. This was associated with the inhibition of Akt/NFκB but not of YB-1 via the JNK/c-Jun- or Akt pathway. Our results suggest that Ad-DKK3 regulates the expression of MDR1 via Akt/NFκB pathways and that it augments the anti-tumor effects of TMZ in GBM cells.
(徳島大学機関リポジトリ): ● Metadata: 112895
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s11060-018-2894-5
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29779087; ● Summary page in Scopus @ Elsevier: 2-s2.0-85047143200

(徳島大学機関リポジトリ: 112895, DOI: 10.1007/s11060-018-2894-5, PubMed: 29779087, Elsevier: Scopus) Yuki Yamamoto, Nobuaki Yamamoto, Junichiro Satomi, Idumi Yamaguchi, Masaaki Korai, Yasuhisa Kanematsu, Yasushi Takagi and Ryuji Kaji :
Dural arteriovenous fistula in the superior orbital fissure,
Surgical Neurology International, Vol.9, No.1, 95, 2018.

(要約): Dural arteriovenous fistulas (dAVFs) are extremely rare in the superior orbital fissure, and they exhibit ocular symptoms similar to the dAVF in the cavernous sinus because of the intraorbital venous congestion. Hence, the distinction of these conditions is imperative because of some inherent differences in endovascular treatment techniques. A 58-year-old woman presented with a gradually worsening left eyeball protrusion and conjunctival congestion. The digital subtraction angiography revealed a dAVF with a shunting point in the left superior orbital fissure. Moreover, the inferolateral trunk of the left internal carotid artery and the left middle meningeal artery were involved as feeding arteries. Shunting blood flow drained into the facial vein through the superior ophthalmic vein (SOV) but not into the cavernous sinus, which was located just posterior to the superior orbital fissure. We performed transvenous coil embolization in the SOV through the facial vein, and the symptoms disappeared completely. We experienced a case of a dAVF in the superior orbital fissure. This case presented a possibility of the presence of one subtype of the dAVF in the part of the cavernous sinus separated at the superior orbital fissure in front. Transvenous coil embolization in the SOV through the facial vein efficiently occluded the fistula.
(出版サイトへのリンク): ● Publication site (DOI): 10.4103/sni.sni_46_18
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29888029; ● Search Scopus @ Elsevier (PMID): 29888029; ● Search Scopus @ Elsevier (DOI): 10.4103/sni.sni_46_18

(DOI: 10.4103/sni.sni_46_18, PubMed: 29888029) Y Helmanto, T Sunohara, A Faried, Yasushi Takagi, J Takahashi, T Maki and S Miyamoto :
Transplantation of feeder-free human induced pluripotent stem cell-derived cortical neuron progenitors in adult male Wistar rats with focal brain ischemia,
Journal of Neuroscience Research, Vol.96, No.5, 863-874, 2018.

(要約): The use of human induced pluripotent stem cells (hiPSCs) eliminates the ethical issues associated with fetal or embryonic materials, thus allowing progress in cell therapy research for ischemic stroke. Strict regulation of cell therapy development requires the xeno-free condition to eliminate clinical complications. Maintenance of hiPSCs with feeder-free condition presents a higher degree of spontaneous differentiation in comparison with conventional cultures. Therefore, feeder-free derivation might be not ideal for developing transplantable hiPSC derivatives. We developed the feeder-free condition for differentiation of cortical neurons from hiPSCs. Then, we evaluated the cells' characteristics upon transplantation into the sham and focal brain ischemia on adult male Wistar rats. Grafts in lesioned brains demonstrated polarized reactivity toward the ischemic border, indicated by directional preferences in axonal outgrowth and cellular migration, with no influence on graft survival. Following the transplantation, forelimb asymmetry was better restored compared with controls. Herein, we provide evidence to support the use of the xeno-free condition for the development of cell therapy for ischemic stroke.
(出版サイトへのリンク): ● Publication site (DOI): 10.1002/jnr.24197
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29110329; ● Summary page in Scopus @ Elsevier: 2-s2.0-85043983951

(DOI: 10.1002/jnr.24197, PubMed: 29110329, Elsevier: Scopus) Yasushi Takagi, H Hadeishi, Y Mineharu, K Yoshida, K Ogasawara, A Ogawa and S Miyamamoto :
Initially Missed or Delayed Diagnosis of Subarachnoid Hemorrhage: A Nationwide Survey of Contributing Factors and Outcomes in Japan.,
Journal of Stroke & Cerebrovascular Diseases, Vol.27, No.4, 871-877, 2018.

(要約): Subarachnoid hemorrhage (SAH) remains a significant cause of mortality in Japan. The Japan Stroke Society set out to conduct a nationwide survey to identify contributing factors and outcomes of SAH misdiagnosis. We initially surveyed 737 training institutes and 1259 departments in Japan between April 2012 and March 2014 for the presence of misdiagnosed SAH. Clinical information was then sought from respondents with a positive misdiagnosis. Information on 579 misdiagnosed cases was collected. Most initial misdiagnoses occurred in nonteaching hospitals (72%). Of those presenting with headache, 55% did not undergo a computed tomography (CT) scan. In addition, SAH was missed in the patients who underwent CT scans. The clinically diagnosed rerupture rate was 27%. Mortality among all cases was 11%. Institutes achieving a final diagnosis were staffed by neurologists or neurosurgeons. Multivariate logistic regression analysis indicated that age (≥65), consciousness level (Japan Coma Scale score at correct diagnosis), rerupture of an aneurysm, and no treatment by clipping or coiling were significantly associated with poor clinical outcome. The prognosis of misdiagnosis of SAH is severe. Neuroradiological assessment and correct diagnosis can prevent SAH misdiagnosis. When there is a possible diagnosis of SAH, consultation with a specialist is important.
(キーワード): Age Factors / Aged / Delayed Diagnosis / Diagnostic Errors / Embolization, Therapeutic / Female / Health Care Surveys / Humans / Japan / Logistic Models / Magnetic Resonance Imaging / Male / Middle Aged / Multivariate Analysis / Neurosurgical Procedures / Odds Ratio / Predictive Value of Tests / Reproducibility of Results / Risk Factors / Subarachnoid Hemorrhage / Time Factors / Tomography, X-Ray Computed / Treatment Outcome
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jstrokecerebrovasdis.2017.10.024
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29217366; ● Summary page in Scopus @ Elsevier: 2-s2.0-85036626734

(DOI: 10.1016/j.jstrokecerebrovasdis.2017.10.024, PubMed: 29217366, Elsevier: Scopus) Takaaki Morimoto, Jun-ichiro Enmi, Yorito Hattori, Satoshi Iguchi, Satoshi Saito, Kouji H. Harada, Hiroko Okuda, Yohei Mineharu, Yasushi Takagi, Shohab Youssefian, Hidehiro Iida, Susumu Miyamoto, Masafumi Ihara, Hatasu Kobayashi and Akio Koizumi :
Dysregulation of RNF213 promotes cerebral hypoperfusion.,
Scientific Reports, Vol.8, No.1, 3607, 2018.

(要約): RNF213 is a susceptibility gene for moyamoya disease, yet its exact functions remain unclear. To evaluate the role of RNF213 in adaptation of cerebral blood flow (CBF) under cerebral hypoperfusion, we performed bilateral common carotid artery stenosis surgery using external microcoils on Rnf213 knockout (KO) and vascular endothelial cell-specific Rnf213 mutant (human p.R4810K orthologue) transgenic (EC-Tg) mice. Temporal CBF changes were measured by arterial spin-labelling magnetic resonance imaging. In the cortical area, no significant difference in CBF was found before surgery between the genotypes. Three of eight (37.5%) KO mice died after surgery but all wild-type and EC-Tg mice survived hypoperfusion. KO mice had a significantly more severe reduction in CBF on day 7 than wild-type mice (KO, 29.7% of baseline level; wild-type, 49.3%; p = 0.038), while CBF restoration on day 28 was significantly impaired in both KO (50.0%) and EC-Tg (56.1%) mice compared with wild-type mice (69.5%; p = 0.031 and 0.037, respectively). Changes in the subcortical area also showed the same tendency as the cortical area. Additionally, histological analysis demonstrated that angiogenesis was impaired in both EC-Tg and KO mice. These results are indicative of the essential role of RNF213 in the maintenance of CBF.
(徳島大学機関リポジトリ): ● Metadata: 112440
(出版サイトへのリンク): ● Publication site (DOI): 10.1038/s41598-018-22064-8
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29483617; ● Summary page in Scopus @ Elsevier: 2-s2.0-85042728382

(徳島大学機関リポジトリ: 112440, DOI: 10.1038/s41598-018-22064-8, PubMed: 29483617, Elsevier: Scopus) 牟礼英生, 森垣龍馬, 宮本亮介, 中瀧理仁, 岡久哲也, 加藤真介, 梶龍兒, 髙木康志, 永廣信治, 後藤惠 :
ジストニアDBS治療における多職種連携,
機能的脳神経外科, Vol.57, 35-39, 2018年.

(キーワード): ジストニア / 脳深部刺激療法 / 多職種連携 / Dystonia / DBS / Multidisciplinary / Collaboration
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1520572358412476800

(CiNii: 1520572358412476800) Takayuki Kikuchi, Akira Ishii, Hideo Chihara, Daisuke Arai, Mitsushige Ando, Yohei Takenobu, Tomohisa Okada, Yasushi Takagi and Susumu Miyamoto :
Occlusion Status on Magnetic Resonance Angiography Is Associated with Risk of Delayed Ischemic Events in Cerebral Aneurysms Treated with Stent-Assisted Coiling.,
World Neurosurgery, Vol.107, 226-232, 2017.

(要約): Management after stent-assisted coiling (SAC) for unruptured intracranial aneurysm is sometimes difficult because close monitoring for ischemic events for a long period of time after the procedure is necessary. The purpose of this study was to clarify the usefulness of magnetic resonance angiography (MRA) at follow-up after SAC. Sixty-six consecutive cases of SAC for unruptured intracranial aneurysm in our institute and affiliated hospitals were retrospectively reviewed for a delayed ischemic event. Occlusion status of the aneurysm and stent apposition on time-of-flight (TOF)-MRA, patient demographics, and characteristics of the aneurysms were analyzed for a possible relationship to delayed ischemic events. Over a median follow-up of 755 days, 14 patients had delayed ischemic events after a median follow-up of 230.5 days. All of the ischemic events were transient or asymptomatic. Univariate analysis revealed that the history of hypertension (P = 0.042) and the occlusion status of the aneurysm (P = 0.006) were significantly associated with delayed ischemic events. Multivariate analysis indicated that dome filling had a hazard ratio of 4.96 (95% confidence interval [CI], 1.30-23.60) and 3.74 (95% CI, 1.10-13.34), compared with neck remnant and complete obliteration, respectively. Six of 7 patients who had persistent dome filling during follow-up developed a delayed ischemic event. In this preliminary study, dome filling on follow-up TOF-MRA is a possible risk factor for delayed ischemic events. TOF-MRA could be a modality for tailored management after SAC.
(キーワード): Angiography, Digital Subtraction / Brain Ischemia / Cerebral Angiography / Combined Modality Therapy / Embolization, Therapeutic / Endovascular Procedures / Follow-Up Studies / Humans / Infarction, Middle Cerebral Artery / Intracranial Aneurysm / Magnetic Resonance Angiography / Middle Aged / マルチモーダルイメージング (multimodal imaging) / Platelet Aggregation Inhibitors / Retrospective Studies / Risk Factors / Stents
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.wneu.2017.07.161
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28826708; ● Summary page in Scopus @ Elsevier: 2-s2.0-85028297766

(DOI: 10.1016/j.wneu.2017.07.161, PubMed: 28826708, Elsevier: Scopus) Yoshio Araki, Yasushi Takagi, Yohei Mineharu, Hatasu Kobayashi, Susumu Miyamoto and Toshihiko Wakabayashi :
Rapid contralateral progression of focal cerebral arteriopathy distinguished from RNF213-related moyamoya disease and fibromuscular dysplasia.,
Child's Nervous System, Vol.33, No.8, 1405-1409, 2017.

(要約): Focal cerebral arteriopathy includes unifocal or multifocal lesions that are unilateral or bilateral. Large- and/or medium-sized vessels are involved and can be visualized on angiography. We report a case of cerebral infarction in a 9-year-old Japanese female who presented with a transient ischemic attack. Steno-occlusion involving the distal part of the internal carotid artery, proximal middle cerebral artery, and anterior cerebral artery was observed. Digital subtraction angiography demonstrated a beaded appearance in the cervical portion of the diseased internal carotid artery. Revascularization surgery was performed 45 days after the onset. A new infarction appeared on the other side of the anterior cerebral artery territory 7 months after the first onset. Antiplatelets and vasodilators were administered, and no progression was observed during 18 months of follow-up. Genetic analysis did not show ring finger protein 213 (RNF213)-related moyamoya disease, and pathological examination revealed no characteristics of fibromuscular dysplasia. The radiological and genetic features coincided with focal cerebral arteriopathy, which is a distinct entity from fibromuscular dysplasia and RNF213-related moyamoya disease.
(キーワード): Adenosine Triphosphatases / Child / Diffusion Magnetic Resonance Imaging / Female / Fibromuscular Dysplasia / Humans / Magnetic Resonance Angiography / Middle Cerebral Artery / Moyamoya Disease / Mutation / Ubiquitin-Protein Ligases
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s00381-017-3451-9
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28497183; ● Summary page in Scopus @ Elsevier: 2-s2.0-85018662847

(DOI: 10.1007/s00381-017-3451-9, PubMed: 28497183, Elsevier: Scopus) Yoshiko Matsuda, Yohei Mineharu, Mitsuru Kimura, Yasushi Takagi, Hatasu Kobayashi, Toshiaki Hitomi, Kouji H. Harada, Yoshito Uchihashi, Takeshi Funaki, Susumu Miyamoto and Akio Koizumi :
RNF213 p.R4810K Variant and Intracranial Arterial Stenosis or Occlusion in Relatives of Patients with Moyamoya Disease.,
Journal of Stroke & Cerebrovascular Diseases, Vol.26, No.8, 1841-1847, 2017.

(要約): This study aimed to determine the effectiveness of genetic testing for the p.R4810K variant (rs112735431) of the Mysterin/RNF213 gene, which is associated with moyamoya disease and other intracranial vascular diseases, in the family members of patients with moyamoya disease. We performed genotyping of the RNF213 p.R4810K polymorphism and magnetic resonance angiography on 59 relatives of 18 index patients with moyamoya disease. Nineteen individuals had follow-up magnetic resonance angiography with a mean follow-up period of 7.2 years. Six of the 34 individuals with the GA genotype (heterozygotes for p.R4810K) showed intracranial steno-occlusive lesions in the magnetic resonance angiography, whereas none of the 25 individuals with the GG genotype (wild type) showed any abnormalities. Follow-up magnetic resonance angiography revealed de novo lesions in 2 and disease progression in 1 of the 11 individuals with the GA genotype, despite none of the 8 individuals with the GG genotype showing any changes. Accordingly, 8 individuals had steno-occlusive lesions at the last follow-up, and all had the p.R4810K risk variant. The prevalence of steno-occlusive intracranial arterial diseases in family members with the p.R4810K variant was 23.5% (95% confidence interval: 9.27%-37.78%), which was significantly higher than in those without the variant (0%, P = .0160). Genotyping of the p.R4810K missense variant is useful for identifying individuals with an elevated risk for steno-occlusive intracranial arterial diseases in the family members of patients with moyamoya disease.
(キーワード): Adenosine Triphosphatases / Adolescent / Adult / Aged / Aged, 80 and over / Constriction, Pathologic / Disease Progression / Female / Gene Frequency / Genetic Association Studies / Genetic Predisposition to Disease / Heredity / Heterozygote / Homozygote / Humans / Intracranial Arteriosclerosis / 日本 (Japan) / Magnetic Resonance Angiography / Male / Middle Aged / Moyamoya Disease / Pedigree / Phenotype / Polymorphism, Genetic / Prevalence / Risk Factors / Time Factors / Ubiquitin-Protein Ligases / Young Adult
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jstrokecerebrovasdis.2017.04.019
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28506590; ● Summary page in Scopus @ Elsevier: 2-s2.0-85019147342

(DOI: 10.1016/j.jstrokecerebrovasdis.2017.04.019, PubMed: 28506590, Elsevier: Scopus) Takaaki Morimoto, Yohei Mineharu, Koh Ono, Masahiro Nakatochi, Sahoko Ichihara, Risako Kabata, Yasushi Takagi, Yang Cao, Lanying Zhao, Hatasu Kobayashi, Kouji H. Harada, Katsunobu Takenaka, Takeshi Funaki, Mitsuhiro Yokota, Tatsuaki Matsubara, Ken Yamamoto, Hideo Izawa, Takeshi Kimura, Susumu Miyamoto and Akio Koizumi :
Significant association of RNF213 p.R4810K, a moyamoya susceptibility variant, with coronary artery disease.,
PLoS ONE, Vol.12, No.4, e0175649, 2017.

(要約): The genetic architecture of coronary artery disease has not been fully elucidated, especially in Asian countries. Moyamoya disease is a progressive cerebrovascular disease that is reported to be complicated by coronary artery disease. Because most Japanese patients with moyamoya disease carry the p.R4810K variant of the ring finger 213 gene (RNF213), this may also be a risk factor for coronary artery disease; however, this possibility has never been tested. We genotyped the RNF213 p.R4810K variant in 956 coronary artery disease patients and 716 controls and tested the association between p.R4810K and coronary artery disease. We also validated the association in an independent population of 311 coronary artery disease patients and 494 controls. In the replication study, the p.R4810K genotypes were imputed from genome-wide genotyping data based on the 1000 Genomes Project. We used multivariate logistic regression analyses to adjust for well-known risk factors such as dyslipidemia and smoking habits. In the primary study population, the frequency of the minor variant allele was significantly higher in patients with coronary artery disease than in controls (2.04% vs. 0.98%), with an odds ratio of 2.11 (p = 0.017). Under a dominant model, after adjustment for risk factors, the association remained significant, with an odds ratio of 2.90 (95% confidence interval: 1.37-6.61; p = 0.005). In the replication study, the association was significant after adjustment for age and sex (odds ratio = 4.99; 95% confidence interval: 1.16-21.53; p = 0.031), although it did not reach statistical significance when further adjusted for risk factors (odds ratio = 3.82; 95% confidence interval: 0.87-16.77; p = 0.076). The RNF213 p.R4810K variant appears to be significantly associated with coronary artery disease in the Japanese population.
(キーワード): Adenosine Triphosphatases / Aged / Aged, 80 and over / Amino Acid Substitution / Asian Continental Ancestry Group / Case-Control Studies / Coronary Artery Disease / Female / Genetic Predisposition to Disease / Humans / Japan / Male / Middle Aged / Moyamoya Disease / Polymorphism, Single Nucleotide / Risk Factors / Ubiquitin-Protein Ligases
(徳島大学機関リポジトリ): ● Metadata: 112364
(出版サイトへのリンク): ● Publication site (DOI): 10.1371/journal.pone.0175649
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28414759; ● Summary page in Scopus @ Elsevier: 2-s2.0-85017628389

(徳島大学機関リポジトリ: 112364, DOI: 10.1371/journal.pone.0175649, PubMed: 28414759, Elsevier: Scopus) Toshinari Kawasaki, Kazumichi Yoshida, Takayuki Kikuchi, Akira Ishii, Yasushi Takagi and Susumu Miyamoto :
Ruptured Aneurysms of the Occipital Artery Associated with Congenital Occipital Bone Defect.,
World Neurosurgery, Vol.97, 759.e13-759.e15, 2017.

(要約): Traumatic aneurysms of the superficial temporal artery have been frequently reported in the literature, whereas traumatic aneurysms of the occipital artery (OA) are extremely rare. A 30-year-old man had been followed at another hospital for meningoencephalocele associated with his congenital occipital bone defect. He was admitted to our hospital with a chief complaint of neck swelling and pain during a football game. Computed tomography and magnetic resonance imaging showed a hematoma in his right neck along with the meningoencephalocele. In addition, it showed an atrophic cerebellum with a cyst protruding from his occipital bone defect. Digital subtraction angiography of the right OA showed 3 aneurysms responsible for the large hematoma in his neck. Endovascular embolization with 20% N-butyl-2-cyanoacrylate was performed for treatment of the ruptured aneurysms followed by emergent surgical evacuation of the hematoma. An occipital cranioplasty with titanium mesh was performed 10 months after the emergent intervention. In this patient, the congenital occipital bone defect with meningoencephalocele might have been the remote source of risk for traumatic pseudoaneurysms along the muscle branches of the OA.
(キーワード): Adult / Aneurysm, Ruptured / Cerebral Arteries / Humans / Intracranial Aneurysm / Male / Occipital Bone
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.wneu.2016.09.116
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27742510; ● Summary page in Scopus @ Elsevier: 2-s2.0-85005814169

(DOI: 10.1016/j.wneu.2016.09.116, PubMed: 27742510, Elsevier: Scopus) Yoichi Nakayama, Yohei Mineharu, Yoshiki Arawaka, Sei Nishida, Hirofumi Tsuji, Hidehiko Miyake, Maki Yamaguchi, Sachiko Minamiguchi, Yasushi Takagi and Susumu Miyamoto :
Cerebral amyloid angiopathy in a young man with a history of traumatic brain injury: a case report and review of the literature.,
Acta Neurochirurgica, Vol.159, No.1, 15-18, 2017.

(要約): Cerebral amyloid angiopathy (CAA), a cause of recurrent and multiple lobar hemorrhages, characteristically occurs in persons aged ≥55 years. We report a case of a 32-year-old male who had recurrent hemorrhage in the left multiple lobes, with a history of traumatic brain injury and hematoma evacuation at the age of 1 year. He underwent surgical treatment and was histopathologically diagnosed as having CAA. The literature review yielded six CAA cases, including ours, aged less than 55 years. All were male and four had histories of severe TBI, suggesting that male sex and TBI may be associated with CAA in young persons.
(キーワード): Adult / Brain Injuries, Traumatic / Cerebral Amyloid Angiopathy / Cerebral Hemorrhage / Humans / Male
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s00701-016-3004-0
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27812816; ● Summary page in Scopus @ Elsevier: 2-s2.0-84994309547

(DOI: 10.1007/s00701-016-3004-0, PubMed: 27812816, Elsevier: Scopus)

MISC

Izumi Yamaguchi, Yasuhisa Kanematsu, Kenji Shimada, Nobuaki Yamamoto, Masaaki Korai, Kazuhisa Miyake, Takeshi Miyamoto, Shu Sogabe, Eiji Shikata, Manabu Ishihara, Yuki Yamamoto, Kazutaka KURODA and Yasushi Takagi :
Evaluation of Serial Intra-Arterial Indocyanine Green Videoangiography in the Surgical Treatment of Cranial and Craniocervical Junction Arteriovenous Fistulae: A Case Series,
Operative Neurosurgery, Vol.25, No.3, 292-300, 2023.

(要約): Intravenous indocyanine green (IV-ICG) videoangiography is commonly performed to detect blood flow in the microscopic view. However, intra-arterial ICG (IA-ICG) videoangiography provides high-contrast imaging, repeatability within a short period of time, and clear-cut separation of the arterial and venous phases compared with IV-ICG. These features are useful for detecting retrograde venous drainage (RVD) and shunt occlusion in arteriovenous fistulae (AVF) surgery. This study aimed to investigate whether IA-ICG videoangiography can be repeatable within a short period of time and be useful for detecting RVD and shunt occlusion in cranial- and craniocervical junction (CCJ)-AVF surgery. Between January 2012 and December 2022, 50 patients were treated with endovascular or surgical intervention for cranial- and CCJ-AVF at Tokushima University Hospital. Of these, 5 patients (6 lesions) underwent open surgery with IA-ICG videoangiography in a hybrid operating room. We analyzed the data of these 5 patients (6 lesions). There were 4/patient (median, range 2-12) and 3.5/lesion (median, range 2-10) intraoperative IA-ICG runs. IA-ICG videoangiography detected RVD in all patients. Clearance of IA-ICG-induced fluorescence was achieved within 30 seconds in all patients at each region of interest. After the disconnection of the fistulae, IA-ICG videoangiography and intraoperative digital subtraction angiography (DSA) confirmed the disappearance of RVD in all patients. There were no complications associated with IA-ICG videoangiography. This study showed that IA-ICG videoangiography is repeatable within a short period of time before and after obliteration and can be useful for detecting RVD and shunt occlusion in cranial- and CCJ-AVF surgery. IA-ICG videoangiography also allows intraoperative DSA studies in a hybrid operating room. Considering the recent advancements in hybrid operating rooms, combining IA-ICG videoangiography with intraoperative DSA is a useful strategy for cranial- and CCJ-AVF surgery.
(キーワード): Humans / Indocyanine Green / Coloring Agents / Neurosurgical Procedures / Vascular Surgical Procedures / Arteries
(出版サイトへのリンク): ● Publication site (DOI): 10.1227/ons.0000000000000796
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37345942; ● Summary page in Scopus @ Elsevier: 2-s2.0-85168222953

(DOI: 10.1227/ons.0000000000000796, PubMed: 37345942, Elsevier: Scopus) Yuki Matsumoto, Yuki Kanazawa, Yuki Kinjo, Masafumi Harada, Toshiaki Miyati, Hiroaki Hayashi, Mitsuharu Miyoshi, Naoki Maeda, Yasuhisa Kanematsu, Yasushi Takagi and Akihiro Haga :
Evaluation of Blood Flow and Plaque Vulnerability in Carotid Artery Stenosis Focusing on Morphological and Component Characteristics,
Proceedings of the 2022 ISMRM & SMRT ANNUAL MEETING & EXHIBITION, No.3783, 2022, 2022.

総説・解説

高麗雅章, 多田恵曜, 北里慶子, 橋本友紀, 髙木康志 :
脳動脈瘤の発生のメカニズム,
Clinical Neuroscience, Vol.41, No.10, 1332-1335, 2023年10月.

(キーワード): 脳動脈瘤 (brain aneurysm) / くも膜下出血

髙木康志 :
AVMに対する治療選択と外科治療の実際(解説/特集),
脳神経外科ジャーナル, Vol.26, No.2, 117-124, 2017年.

(出版サイトへのリンク): ● Publication site (DOI): 10.7887/jcns.26.117
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.7887/jcns.26.117

(DOI: 10.7887/jcns.26.117) 髙木康志 :
【中枢神経系の血管奇形-最新情報】脳動静脈奇形(AVM) AVMの分類と治療方針(解説/特集),
Clinical Neuroscience, Vol.35, No.10, 1172-1175, 2017年. 髙木康志 :
【動脈・静脈の疾患(下)-最新の診断・治療動向-】動脈・静脈の疾患(臓器別) 脳血管疾患もやもや病診断(解説/特集),
日本臨牀, Vol.75, 691-698, 2017年.

講演・発表

Yasushi Takagi :
Improvement in AVM treatment after ARUBA, especially large AVM,
Seoul, Sep. 2024. Taku Matsuda, Ryoma Morigaki, Hiroaki Hayasawa, Hiroshi Koyama, Teruo Oda, Kazuhisa Miyake and Yasushi Takagi :
Striatal parvalbumin interneurons, not cholinergic interneurons, are activated in a mouse model of cerebellar dystonia,
NEURO2024, Fukuoka, Jul. 2024. Yuki Kanazawa, Tosiaki Miyati, Masafumi Harada, Mitsuharu Miyoshi, Mayuka Seguchi, Hiroaki Hayashi, Yuki Matsumoto, Yasuhisa Kanematsu and Yasushi Takagi :
Metabolic Analysis Within an Atherosclerotic Plaque Using Chemical Exchange Saturation Transfer Imaging,
The 109th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA2023), Chicago, Nov. 2023. Yasushi Takagi :
Multimodality Treatment of Cerebral AVMs in Post-ARUBA Era,
The 16th Korea-Japan Joint Conference on Surgery for Cerebral Stroke, Gifu, Sep. 2023. Yuki Kanazawa, Tosiaki Miyati, Masafumi Harada, Mitsuharu Miyoshi, Yuki Matsumoto, Hiroaki Hayashi, Yasuhisa Kanematsu and Yasushi Takagi :
Evaluation of Biological Metabolic Activity within an Atherosclerotic Plaque using Chemical Exchange Saturation Transfer Imaging,
The 32st Annual Meeting of ISMRM, Toronto, Jun. 2023. Mayuka Seguchi, Yuki Kanazawa, Tosiaki Miyati, Masafumi Harada, Mitsuharu Miyoshi, Yuki Matsumoto, Hiroaki Hayashi, Yasuhisa Kanematsu and Yasushi Takagi :
Diffusion weighted-viscosity imaging for atherosclerotic plaques,
The 32st Annual Meeting of ISMRM, Toronto, Jun. 2023. Joji Fujikawa, Ryoma Morigaki, Kazuhisa Miyake, Taku Matsuda, Hiroshi Koyama, Teruo Oda, Nobuaki Yamamoto, Yuishin Izumi, Hideo Mure, Satoshi Goto and Yasushi Takagi :
Cranial geometry in patients with dystonia,
The 13th Scientific meeting of Asian Australasian Society for Stereotactic and Functional Neurosurgery (AASSFN 2023), Osaka, Apr. 2023. NAKANISHI Hiroshi, Ryoma Morigaki, Nobuaki Yamamoto, Joji Fujikawa, Teruo Oda, OMAE Hiroshi, Yuishin Izumi and Yasushi Takagi :
The effect of Rikaba, a hybrid physical exercise salon for Parkinson's disease patients,
The 13th Scientific meeting of Asian Australasian Society for Stereotactic and Functional Neurosurgery (AASSFN 2023), Osaka, Apr. 2023. Hideo Mure, Ryoma Morigaki, Ryosuke Miyamoto, Kazuhisa Miyake, Taku Matsuda, Hiroshi Koyama and Yasushi Takagi :
Long-term follow-up of 12 patients treated with bilateral pallidal stimulation for tardive dystonia,
13th Scientific meeting of Asian Australasian Society for Streotactic and Functional Neurosurgery, Osaka, Apr. 2023. OMAE Hiroshi, Ryoma Morigaki, Kazuhisa Miyake, Taku Matsuda, 中野渡友香, Megumi Kuno, Tetsuya Matsuura and Yasushi Takagi :
Cognitive changes due to subthalamic nucleus deep brain stimulation in elderly Parkinson's Disease,
The 13th Scientific meeting of Asian Australasian Society for Stereotactic and Functional Neurosurgery (AASSFN 2023), Osaka, Apr. 2023. Ryoma Morigaki, Maya Anzai, Joji Fujikawa, Teruo Oda, Hayasawa Hiroaki, Matsuda Taku, Jiro Kasahara and Yasushi Takagi :
Changes in phosphodiesterase 10A in mice model of levodopa-induced dyskinesia,
The 13th Scientific meeting of Asian Australasian Society for Stereotactic and Functional Neurosurgery (AASSFN 2023), Osaka, Apr. 2023. Yasushi Takagi :
AVM surgery using intra-arterial ICG videoangiography in hybrid operating room.,
Joint Neurosurgical Convention2023, Vol.-, No.-, -, Honolulu, Feb. 2023. Yasushi Takagi :
AVM surgery using intra-arterial ICG videoangiography in hybrid operating room,
10th European Japanese Cerebrovascular Congress, Kyoto, Nov. 2022. Yuki Matsumoto, Yuki Kanazawa, Yuki Kinjo, Masafumi Harada, Toshiaki Miyati, Hiroaki Hayashi, Mitsuharu Miyoshi, Naoki Maeda, Yasuhisa Kanematsu, Yasushi Takagi and Akihiro Haga :
Evaluation of Blood Flow and Plaque Vulnerability in Carotid Artery Stenosis Focusing on Morphological and Component Characteristics,
ISMRM 30th Annual Meeting, London, May 2022. Naoki Maeda, Yuki Kanazawa, Yuki Kinjo, Yuki Matsumoto, Masafumi Harada, Tosiaki Miyati, Hiroaki Hayashi, Mitsuharu Miyoshi, Yasuhisa Kanematsu, Yasushi Takagi and Akihiro Haga :
Is it possible to evaluate morphological carotid artery stenosis information using NASCET criteria?,
RSNA2021 (Radiological Society of North America), Chicago, Nov. 2021. Yoshiteru Tada, Toshitaka Fujihara, Kenji Shimada, Nobuaki Yamamoto, Hiroki Yamazaki, Yuishin Izumi, Masafumi Harada, Yasuhisa Kanematsu and Yasushi Takagi :
Peri-ictal normal arterial spin labeling imaging in patients with seizures,
13 回アジア・オセアニアてんかん学会(13th AOEC), Jun. 2021. Ryoma Morigaki, Masatoshi Ogawa, Shinya Ohkita, Taku Matsuda, Yasushi Takagi and Satoshi Goto :
Phospho-serine 276 of nuclear factor kappa b is involved in the genesis of l-dopa-induced dyskinesia,
The Journal of Neuroscience, 2021. Yuki Kanazawa, Masafumi Harada, Mitsuharu Miyoshi, Takashi Abe, Yuki Matsumoto and Yasushi Takagi :
Characterization of Brain Tumors using Amide Proton and Nuclear Overhauser Effect at 3 Tesla MR Scanner,
ISMRM Virtual Conference, Aug. 2020. Yuki Kanazawa, Masafumi Harada, Tosiaki Miyati, Takashi Abe, Mitsuharu Miyoshi, Yuki Matsumoto, Hiroaki Hayashi, Yasuhisa Kanematsu and Yasushi Takagi :
Chemical Exchange Saturation Transfer Imaging for Atherosclerotic Plaques,
ISMRM Virtual Conference, Aug. 2020. Idumi Yamaguchi, Tadashi Yamaguchi, Eiji Shikata, 北里慶子 and Yasushi Takagi :
Down-regulation of PD-L1 via FKBP5 lowered by a cyclooxygenase-2 inhibtor in GSCs and GBM cells may be attributable to enhance antitumor effects of immunotherapy,
Society for NeuroOncology 2019, Nov. 2019. Ryoma Morigaki, S Okita, Hideo Mure, Yasushi Takagi and S Goto :
Olfactory type g-protein alfa subunit related changes in the striatum underlie the genesis of L-DOPA induced dyskinesiaBrain and Brain PET2019,
Brain and Brain PET2019, Jul. 2019. Tadashi Yamaguchi, Keiko T Kitazato, Eiji Shikata, Idumi Yamaguchi, Takeshi Miyamoto, Masaaki Korai, Kenji Shimada, Yoshiteru Tada, Yasuhisa Kanematsu and Yasushi Takagi :
Pro-inflammatory response promoted by Porphyromonas gingivalis lipopolysaccharide enhances the rupture of experimental intracranial aneurysms.,
Brain and Brain PET2019, Yokohama, Jul. 2019. Ryoma Morigaki, Shinya Ohkita, Hideo Mure, Yasushi Takagi and Satoshi Goto :
Olfactory type G-protein alfa subunit related changes in the striatum underlie the genesis of L-dopa-induced dyskinesia,
Journal of Cerebral Blood Flow and Metabolism, Yokohama, Jun. 2019. Yuki Yamamoto, Nobuaki Yamamoto, K Kuroda, Yasuhisa Kanematsu, Masaaki Korai, Kenji Shimada, Yuishin Izumi and Yasushi Takagi :
High White Blood Cell Count is a Risk Factor for Contrast-Induced Nephropathy following Mechanical Thrombectomy,
The 5th European Stroke Organization Conference, ESOC 2019, Milan, May 2019. Nobuaki Yamamoto, Yuki Yamamoto, Masaaki Korai, Kenji Shimada, Yasuhisa Kanematsu, Yuishin Izumi, Yasushi Takagi and Ryuji Kaji :
Hyperintense Signals on Arterial Spin-Labeled Imaging as a predictor for favorable outcome after Late Time Window Thrombectomy,
The 5th European Stroke Organization Conference, ESOC 2019, Milan, May 2019. Yasushi Takagi :
treatment of brain arteriovenous malformations -Current status- Symposium,
第14回韓日合同脳卒中の外科学会(14th KJJC), Apr. 2019. Eiji Shikata, Tetsuya Tamura, Kiyohito Shinnno, N Shinohara, Y Okayama, Yasuhisa Kanematsu and Yasushi Takagi :
Separate management of water-electrolyte balance using maintenance fluid and salt leads to a favorable prognosis after aneurysmal subarachnoid hemorrhage,
11th World Stroke Congress 2018, Oct. 2018. Kyoko Nishi, Yasushi Takagi, Yasuhisa Kanematsu, Ryuji Kaji, Y Hamada, T Takagi, S Katoh and Shinji Nagahiro :
Development and future prospects of Tokushima University Hospital stroke care unit (SCU),
11th World Stroke Congress 2018, Montreal, Oct. 2018. 山口泉, 四方英二, 高麗雅章, 兼松康久, 里見淳一郎, 北里慶子, 永廣信治, 髙木康志 :
Retrospective study of patients with in-hospital stroke,
11th World Stroke Congress 2018, モントリオール, 2018年10月. Tadashi Yamaguchi, Takeshi Miyamoto, Masaaki Korai, Kenji Shimada, Yoshiteru Tada, Yasuhisa Kanematsu, Junichiro Satomi, Shinji Nagahiro and Yasushi Takagi :
Estrogen deficiency activates inflammasome in a rat model of intracranial aneurysms,
11th World Stroke Congress 2018, Montreal, Oct. 2018. Masaaki Korai, Yasuhisa Kanematsu, Idumi Yamaguchi, Nobuaki Yamamoto, Yuki Yamamoto, Junichiro Satomi and Yasushi Takagi :
Treatment strategy and outcom of ruptured vertebral artry dissecting aneurysms,
World Live Neurovascular Conference 2018, 神戸市, Apr. 2018. Kenji Shono, Izumi Yamaguchi, Toshitaka Fujihara, Keiko Kitazato, Kohhei Nakajima, Yoshifumi Mizobuchi, Hideo Mure, Kohhei Nakajima, Junichiro Satomi, Shinji Nagahiro and Yasushi Takagi :
Celecoxib inhibits proliferation and induces apoptosis in glioma stem cells and an animal model of glioblastoma.,
22ND ANNUAL SCIENTIFIC MEETING AND EDUCATION DAY OF THE SOCIETY FOR NEURO-ONCOLOGY, San Francisco, Nov. 2017. 松田拓, 原慶次郎, 鈴木海斗, 三宅一央, 髙木康志 :
外傷後の高次脳機能障害の精査で脳脊髄液漏出症と診断された一例,
日本脳神経外科学会第83回学術総会, 2024年10月. 島田健司, 髙木康志 :
当施設における脳動静脈奇形の治療適応および成績とその変遷,
日本脳神経外科学会第83回学術総会, 2024年10月. 安積麻衣, 中島公平, 石橋広樹, 髙木康志 :
当院におけるシャント手術の腹側合併症回避の工夫―腹腔鏡が有効であった1例と今後の取り組み,
日本脳神経外科学会第83回学術総会, 2024年10月. 高麗雅章, 宮本健志, 石原学, 島田健司, 髙木康志 :
破裂動脈瘤に対してコイル塞栓術を施行し再治療を要した症例の特徴,
日本脳神経外科学会第83回学術総会, 2024年10月. 森垣龍馬, 中西浩史, 小田輝王, 藤川丈自, 大前博司, 河原崎貴光, 山本伸昭, 立花亜由美, 尾崎智樹, 伊賀淳一, 髙木康志 :
多職種連携によりパーキンソン病患者用サロンから開発した介護医療補助システム,
日本脳神経外科学会第83回学術総会, 2024年10月. 藤原敏孝, 多田恵曜, 安積麻衣, 原慶次郎, 中島公平, 髙木康志 :
てんかん重積状態を来した脳腫瘍症例の臨床的特徴と治療成績,
日本脳神経外科学会第83回学術総会, 2024年10月. 三宅一央, 髙木康志 :
正常圧水頭症にてシャント術の効果を認めるも，経過中にその他の診断が得られた症例の検討,
日本脳神経外科学会第83回学術総会, 2024年10月. 鹿草宏, 原慶次郎, 中島公平, 北里慶子, 兼松康久, 髙木康志 :
外傷性脳内微小出血模倣モデルマウスにおける認知機能解析と認知症蛋白の蓄積の検討,
日本脳神経外科学会第83回学術総会, 2024年10月. 宮本健志, 石原学, 高麗雅章, 島田健司, 髙木康志 :
もやもや病に対する血行再建術後におけるArterial spin-labelingの変化,
日本脳神経外科学会第83回学術総会, 2024年10月. 中島公平, 髙木康志 :
当院における膠芽腫の治療成績と治療継続に及ぼす因子の検討,
日本脳神経外科学会第83回学術総会, 2024年10月. 原慶次郎, 安積麻衣, 藤原敏孝, 中島公平, 髙木康志 :
開頭摘出術を行った転移性脳腫瘍の術後成績,
日本脳神経外科学会第83回学術総会, 2024年10月. 多田恵曜, 藤原敏孝, 高麗雅章, 宮本健志, 島田健司, 髙木康志 :
くも膜下出血急性期における非けいれん性てんかん重積状態の転帰,
日本脳神経外科学会第83回学術総会, 2024年10月. 藤原敏孝, 中島公平, 安積麻衣, 原慶次郎, 髙木康志 :
側頭葉悪性脳腫瘍に対する側頭葉切除時のtips,
第29回日本脳腫瘍の外科学会, 2024年10月. 中島公平, 髙木康志 :
当院における膠芽腫の治療成績と治療継続に及ぼす因子の検討,
第29回日本脳腫瘍の外科学会, 2024年10月. 富永洋介, 高麗雅章, 宮本健志, 山本雄貴, 山本伸昭, 島田健司, 髙木康志 :
脳梗塞で発症した大型部分血栓化後大脳動脈瘤の一例,
第33回NPO法人日本脳神経血管内治療学会中国四国地方会, 2024年9月. 砂田陽二郎, 安積麻衣, 中島公平, 藤原敏孝, 原慶次郎, 髙木康志 :
成人発症sellar Atypical Teratoid/Rhabdoid Tumorの一例,
第38回中国四国脳腫瘍研究会, 2024年9月. 藤原敏孝, 多田恵曜, 中島公平, 原慶次郎, 安積麻衣, 髙木康志 :
テント上髄膜腫手術症例におけるてんかん発作および周術期管理についての検討,
第57回日本てんかん学会学術集会, 2024年9月. 多田恵曜, 藤原敏孝, 髙木康志 :
非けいれん性てんかん重積におけるASLでの陰性所見に関与する因子に関する検討,
第57回日本てんかん学会学術集会, 2024年9月. 松田拓, 原慶次郎, 鈴木海斗, 三宅一央, 髙木康志 :
外傷後の高次脳機能障害の精査で脳脊髄液漏出症と診断された一例,
23回舞連カンファレンス, 2024年8月. 髙木康志 :
頭部外傷後の認知症,
第32回日本意識障害学会, 2024年7月. 髙木康志 :

第34回新御茶ノ水セミナー, 2024年6月. 安積麻衣, 中島公平, 石橋広樹, 髙木康志 :
当院におけるシャント手術の腹側合併回避の工夫ー腹腔鏡が有効であった1例と今後の取り組み,
第52回日本小児神経外科学会, 2024年6月. 藤原敏孝, 多田恵曜, 髙木康志 :
迷走神経刺激療法を必要とした80歳以上の高齢者てんかんの特徴と治療経験,
第37回日本老年脳神経外科学会, 2024年4月. 佐原和真, 島田健司, 羽星辰哉, 山口泉, 曽我部周, 高麗雅章, 山本伸昭, 兼松康久, 髙木康志 :
脳梗塞の塞栓源と考えられた頚部外頸動脈瘤の一例,
第97回日本脳神経外科学会中国四国支部会, 2024年4月. 三宅一央, 森垣龍馬, 髙木康志 :
脳深部刺激療法における電極の移動に関する2報告,
第6回中国四国機能神経外科懇話会, 2024年3月. 森垣龍馬, 三宅一央, 松田拓, 髙木康志 :
赤核振戦に伴う痛みに対して著効した脳深部刺激療法の一例,
第6回中国四国機能神経外科懇話会, 2024年3月. 冨田江一, 平山晃斉, 梅嶋宏樹, 常山幸一, 西村明儒, 主田英之, 赤池雅史, 滝沢宏光, 島田光生, 髙木康志, 橋本一郎, 岩田貴 :
徳島大学医学部の系統解剖実習における画像診断技術・病理診断技術・外科的手術手技を取り入れた垂直連携教育の実践,
第129回日本解剖学会全国学術集会, 2024年3月. 髙木康志 :
改訂脳卒中治療ガイドライン2023 脳出血,
STROKE 2024, 2024年3月. 兼松康久, 金澤裕樹, 島田健司, 高麗雅章, 曽我部周, 石原学, 山口泉, 羽星辰哉, 山本伸昭, 黒田一駿, 原田雅史, 髙木康志 :
CEST MRIを用いた頚動脈プラーク診断,
STROKE 2024, 2024年3月. 島田健司, 山口泉, 宮本健志, 曽我部周, 高麗雅章, 山本伸昭, 花岡真実, 兼松康久, 松﨑和仁, 佐藤浩一, 髙木康志 :
骨内シャントの有無による海綿静脈洞部硬膜動静脈瘻の臨床的特徴の違いについて,
STROKE 2024, 2024年3月. 高麗雅章, 榎本紀哉, 羽星辰哉, 山口泉, 曽我部周, 島田健司, 黒田一駿, 山本伸昭, 兼松康久, 松原俊二, 佐藤浩一, 髙木康志 :
円蓋部硬膜動静脈瘻の発生と流出静脈路の経時的な変化についての考察,
STROKE 2024, 2024年3月. 多田恵曜, 藤原敏孝, 髙木康志 :
80歳以上の高齢者てんかんに対する迷走神経刺激療法の治療経験,
第18回日本てんかん学会中国・四国地方会, 2024年2月. 森垣龍馬, 三宅一央, 宮本亮介, 大前博司, 松田拓, 小山広士, 和泉唯信, 髙木康志 :
GPi-DBSが著効した外転型痙攣性発声障害の一例,
第63回日本定位機能外科学会, 2024年2月. 多田恵曜, 藤原敏孝, 髙木康志 :
側頭葉の解剖と前側頭葉切除術の進め方,
第47回日本てんかん外科学会, 2024年2月. 藤原敏孝, 多田恵曜, 髙木康志 :
迷走神経刺激療法を必要とした80歳以上の高齢者てんかんの特徴と治療経験,
第47回日本てんかん外科学会, 2024年2月. 多田恵曜, 藤原敏孝, 冨田江一, 飯田幸治, 髙木康志 :
未固定遺体による前頭葉離断術，前頭葉切除術に対するトレーニング,
第47回日本てんかん外科学会, 2024年2月. 松田拓, 鹿草宏, 佐藤紀, 梅山公子, 松浦哲也, 兼松康久, 髙木康志 :
HALによる歩行訓練で歩容の改善を得られた深部感覚障害による歩行障害の一例,
2023年12月. 高麗雅章, 榎本紀哉, 山口泉, 曽我部周, 島田健司, 黒田一駿, 山本伸昭, 兼松康久, 松原俊二, 佐藤浩一, 髙木康志 :
円蓋部硬膜動静脈瘻の発生と流出静脈路の経時的な変化についての考察,
第39回日本脳神経血管内治療学会学術集会, 2023年11月. 山口泉, 髙木康志 :
高齢者(80歳以上)くも膜下出血に対する脳動脈瘤コイル塞栓術の治療成績の検討,
第39回日本脳神経血管内治療学会学術集会, 2023年11月. 島田健司, 山口泉, 宮本健志, 曽我部周, 高麗雅章, 山本伸昭, 花岡真美, 兼松康久, 松﨑和仁, 佐藤浩一, 髙木康志 :
骨内シャントの有無による海綿静脈洞部硬膜動静脈瘻の臨床的特徴の違いについて,
第39回日本脳神経血管内治療学会学術集会, 2023年11月. 兼松康久, 羽星辰哉, 山口泉, 石原学, 曽我部周, 高麗雅章, 島田健司, 黒田一駿, 山本伸昭, 髙木康志 :
地方におけるICTを活用した急性期脳卒中診療の取り組み,
第39回日本脳神経血管内治療学会学術集会, 2023年11月. 多田恵曜, 藤原敏孝, 髙木康志 :
非けいれん性てんかん重積におけるASLでの陰性所見に関与する因子に関する検討,
日本脳神経外科学会第82回学術総会, 2023年10月. 兼松康久, 羽星辰哉, 山口泉, 石原学, 曽我部周, 高麗雅章, 島田健司, 髙木康志 :
循環器病推進計画の中での地方におけるICTを活用した急性期脳卒中診療の取り組み,
2023年10月. 島田健司, 山口泉, 宮本健志, 曽我部周, 高麗雅章, 山本伸昭, 花岡真実, 兼松康久, 松﨑和仁, 佐藤浩一, 髙木康志 :
骨内シャントの有無による海綿静脈洞部硬膜動静脈瘻の臨床的特徴の違いについて,
日本脳神経外科学会第82回学術集会, 2023年10月. 藤原敏孝, 中島公平, 原慶次郎, 安積麻衣, 松田拓, 多田恵曜, 髙木康志 :
脳腫瘍生検術におけるStealth Autoguideの初期使用経験,
日本脳神経外科学会第82回学術集会, 2023年10月. 藤原敏孝, 多田恵曜, 髙木康志 :
高齢発症てんかんの特徴と治療経験,
第56回日本てんかん学会学術集会, 2023年10月. 多田恵曜, 藤原敏孝, 泉千恵, 福田直也, 中瀧理仁, 森達夫, 山﨑博輝, 髙木康志 :
「誰も取り残さない」てんかんの医療費助成・福祉サービスの提供,
第56回日本てんかん学会学術集会, 2023年10月. 中島公平, 安積麻衣, 藤原敏孝, 原慶次郎, 髙木康志 :
Sellar atypical teratoid/rhabdoid tumor の1例,
第28回日本脳腫瘍の外科学会, 2023年9月. 曽我部周, 兼松康久, 山口泉, 山本伸昭, 島田健司, 髙木康志 :
もやもや病に合併した頭蓋内内頚動脈閉塞に対して再開通療法をおこなった1例,
脳血管内治療ブラッシュアップセミナー2023, 2023年7月. 山本伸昭, 黒田一駿, 山本雄貴, 和泉唯信, 曽我部周, 高麗雅章, 島田健司, 兼松康久, 髙木康志 :
First pass TICI2B患者の追加治療における意義,
第64回日本神経学会学術大会, 2023年5月. 山本雄貴, 山本伸昭, 黒田一駿, 松田知大, 島田健司, 兼松康久, 髙木康志, 和泉唯信 :
頸動脈浮遊血栓に対する，ステントトリーバーによる血栓回収とCASの併用,
第64回日本神経学会学術大会, 2023年5月. 島田健司, 三宅一央, 山口泉, 宮本健志, 曽我部周, 兼松康久, 髙木康志 :
VM摘出術における3D multimodal fusion imageとindocyanine green動注による術中videoangiography併用の有用性,
第32回脳神経外科手術と機器学会(CNTT2023), 2023年4月. 大前博司, 森垣龍馬, 三宅一央, 松田拓, 中野渡友香, 久野恵, 松浦哲也, 髙木康志 :
高齢パーキンソン病患者に対する視床下核脳深部刺激療法による変化の検討,
第36回日本老年脳神経外科学会, 2023年4月. Yuka Hiroshima, Takayoshi Shinya, Hitoshi Ikushima, Youichi Otomi, Hideki Otsuka, Chisato Tonoiso, Akiko Kubo, Takashi Kawanaka, Yasushi Takagi and Masafumi Harada :
Multi-modality Imaging for the Patients with Metastatic Brain Tumors After Stereotactic Irradiation,
The 82nd Annual Meeting of the Japan Radiological Society, Apr. 2023. 手島奈津美, 安積麻衣, 中島公平, 松田知大, 山口泉, 藤原敏孝, 曽我部周, 原慶次郎, 髙木康志 :
術後管理に難渋した頭蓋咽頭腫の1例,
第95回日本脳神経外科学会中国四国支部学術集会, 2023年4月. 髙木康志 :
無症候性脳動静脈奇形の外科・血管内治療の適応,
Stroke2023, 2023年3月. 松田拓, 佐藤紀, 梅村公子, 島田健司, 兼松康久, 髙木康志 :
脳卒中後の深部感覚障害による歩行障害に対してHALリハビリテーションを行い歩容の改善が得られた一例,
STROKE2023, 2023年3月. 高麗雅章, 兼松康久, 島田健司, 山本伸昭, 曽我部周, 石原学, 山口泉, 山本雄貴, 黒田一駿, 髙木康志 :
当院での急性期脳底動脈閉塞に対する血管内治療成績,
第48回日本脳卒中学会学術集会, 2023年3月. 兼松康久, 山口泉, 石原学, 曽我部周, 宮本健志, 高麗雅章, 島田健司, 黒田一駿, 山本伸昭, 山本雄貴, 和泉唯信, 髙木康志 :
徳島県循環器病推進計画の中での急性期脳卒中診療の取り組み,
STROKE2023, 2023年3月. 曽我部周, 宮本健志, 山口泉, 高麗雅章, 島田健司, 兼松康久, 山本雄貴, 山本伸昭, 原田雅史, 和泉唯信, 髙木康志 :
当院での低ASPECTS症例の拡散強調画像に対するRAPIDを用いた後方視的定量評価,
第48回日本脳卒中学会学術集会, 2023年3月. 山口泉, 兼松康久, 溝渕佳史, 多田恵曜, 宮本健志, 曽我部周, 石原学, 鹿草宏, 山本陽子, 松田拓, 北里慶子, 髙木康志 :
硬膜転移が慢性硬膜下血腫の転帰に及ぼす影響についての後視的検討,
第46回日本脳神経外傷学会, 2023年2月. 藤原敏孝, 多田恵曜, 中島公平, 手島奈津美, 髙木康志 :
深部電極留置におけるStealth Autoguideの初期使用経験:Posterior quadrantectomyを行った薬剤抵抗性てんかんの1例,
第17回日本てんかん学会中国・四国地方会, 2023年2月. 多田恵曜, 中瀧理仁, 森達夫, 藤原敏孝, 郷司彩, 山﨑博輝, 泉千恵, 高尾里沙, 多田雅美, 阿部修司, 森健治, 髙木康志 :
地方におけるてんかん支援拠点病院の役割,
第10回全国てんかんセンター協議会, 2023年2月. 藤原敏孝, 多田恵曜, 髙木康志 :
てんかん外科へのアクセス困難な地域における診療支援,
第10回全国てんかんセンター協議会, 2023年2月. 森垣龍馬, 三宅一央, 松田拓, 小山広士, 宮本亮介, 和泉唯信, 中瀧理仁, 梶龍兒, 後藤惠, 髙木康志 :
機能性要素を合併したジストニア症例への手術加療をどう考えるか,
第62回日本定位・機能神経外科学会, 2023年1月. 森垣龍馬, 三宅一央, 小山広士, 松田拓, 髙木康志 :
STN-DBS術後にpainful abdominal contractionとbelly dancer's dyskinesiaを呈したパーキンソン病患者の一例,
第62回日本定位・機能神経外科学会, 2023年1月. 多田恵曜, 藤原敏孝, 板東康司, 山本陽子, 髙木康志 :
てんかん重積に対して迷走神経刺激療法を施行した5例,
第46回日本てんかん外科学会, 2023年1月. 藤原敏孝, 多田恵曜, 板東康司, 髙木康志 :
Posterior quadrantectomyが有効であった脳腫瘍術後薬剤抵抗性てんかんの1例,
第46回日本てんかん外科学会, 2023年1月. 黒田一駿, 山本雄貴, 山本伸昭, 松田知大, 板東康司, 山口泉, 高麗雅章, 島田健司, 兼松康久, 和泉唯信, 髙木康志 :
広範囲シャントを伴った横静脈洞部硬膜動静脈瘻に対して血管内治療を行った1例,
第112回日本神経学会中国・四国地方会, 2022年12月. 砂田陽二郎, 新家崇義, 音見暢一, 音見暢一, 久保典子, 大塚秀樹, 原田雅史, 川中崇, 和泉唯信, 安積麻衣, 中島公平, 髙木康志 :
F-18 FDG PET/CTにて多発性の神経根集積を認めた悪性リンパ腫の一例,
第137回日本医学放射線学会中国・四国地方会, 2022年12月. 松田拓, 鹿草宏, 山口泉, 曽我部周, 島田健司, 兼松康久, 髙木康志, 近藤心, 佐藤紀, 梅村公子, 松浦哲也 :
急性期脳卒中患者におけるロボットスーツHALの即時効果についての検討,
四国医学雑誌, Vol.78, No.5-6, 245, 2022年12月. 曽我部周, 宮本健志, 山口泉, 高麗雅章, 島田健司, 兼松康久, 山本雄貴, 山本伸昭, 原田雅史, 和泉唯信, 和泉唯信, 髙木康志 :
当院の主幹動脈閉塞低ASPECT症例の拡散強調画像に対するRAPIDでの後方視的定量評価,
第38回NPO法人日本脳神経血管内治療学会学術集会, 2022年11月. 山本雄貴, 兼松康久, 山本伸昭, 黒田一駿, 山口泉, 曽我部周, 高麗雅章, 島田健司, 髙木康志, 和泉唯信 :
地方都市における救急医療連携アプリケーションを用いたLVO診断スケールの活用,
第38回NPO法人日本脳神経血管内治療学会学術集会, 2022年11月. 山本伸昭, 黒田一駿, 山本雄貴, 山口泉, 曽我部周, 島田健司, 兼松康久, 和泉唯信, 髙木康志 :
病院前スケール，iSchemaView RAPID導入前後の比較検討,
第38回NPO法人日本脳神経血管内治療学会学術集会, 2022年11月. 山本伸昭, 山本雄貴, 黒田一駿, 山口泉, 曽我部周, 高麗雅章, 島田健司, 兼松康久, 髙木康志, 和泉唯信 :
9Fr long sheathを用いた巨大血栓によるLVO治療例,
第38回NPO法人日本脳神経血管内治療学会学術集会, 2022年11月. 高麗雅章, 兼松康久, 島田健司, 山本伸昭, 曽我部周, 石原学, 山口泉, 山本雄貴, 黒田一駿, 髙木康志 :
当院での急性期脳底動脈閉塞に対する血管内治療成績,
第38回NPO法人日本脳神経血管内治療学会学術集会, 2022年11月. 髙木康志 :
もやもや病登録事業,
日本脳神経外科学会第81回学術総会, 2022年9月. 高麗雅章, 橋本友紀, 宮本健志, 北里慶子, 四方英二, 山口真司, 島田健司, 多田恵曜, 兼松康久, 髙木康志 :
Neutrophil extracellular trapsは脳動脈瘤破裂を促進する,
日本脳神経外科学会第81回学術総会, 2022年9月. 三宅一央, 森垣龍馬, 松田拓, 髙木康志 :
GPi-DBSのinterleaving刺激により，パーキンソン病でのすくみ足に効果を認めた一例,
日本脳神経外科学会第81回学術総会, 2022年9月. 森垣龍馬, 三宅一央, 松田拓, 宮本亮介, 和泉唯信, 中瀧理仁, 髙木康志 :
機能性要素を合併したジストニアへの手術加療,
日本脳神経外科学会第81回学術総会, 2022年9月. 曽我部周, 宮本健志, 山口泉, 高麗雅章, 島田健司, 兼松康久, 山本雄貴, 山本伸昭, 原田雅史, 和泉唯信, 髙木康志 :
当院での主幹動脈閉塞-低ASPECT症例の拡散強調画像に対するRAPIDを用いた後方視的定量評価,
日本脳神経外科学会第81回学術総会, 2022年9月. 安積麻衣, 藤原敏孝, 原慶次郎, 中島公平, 溝渕佳史, 髙木康志 :
術後脳腫瘍患者における転院時転帰予測因子についての検討,
日本脳神経外科学会第81回学術総会, 2022年9月. 兼松康久, 山口泉, 石原学, 曽我部周, 高麗雅章, 多田恵曜, 島田健司, 黒田一駿, 山本雄貴, 山本伸昭, 佐藤健太, 島谷佳光, 亘雄也, 田村哲也, 新野清人, 髙木康志 :
徳島県総合メディカルゾーンでの急性期脳卒中診療の取り組み,
日本脳神経外科学会第81回学術総会, 2022年9月. 多田恵曜, 藤原敏孝, 島田健司, 兼松康久, 髙木康志 :
傍発作時におけるASLおよびDWI所見と発作型の関連性について,
第55回日本てんかん学会学術集会, 2022年9月. 山本雄貴, 兼松康久, 山本伸昭, 黒田一駿, 山口泉, 曽我部周, 高麗雅章, 島田健司, 髙木康志, 和泉唯信 :
徳島市におけるアプリケーションを用いたLVO診断スケールの活用(FAST-ED Tokushima),
第24回中国四国脳卒中研究会, 2022年9月. 兼松康久, 山口泉, 石原学, 曽我部周, 宮本健志, 高麗雅章, 島田健司, 黒田一駿, 山本雄貴, 山本伸昭, 和泉唯信, 髙木康志 :
徳島県循環器病推進計画の中での急性期脳卒中診療の取り組み,
徳島医学会学術集会, 2022年7月. 安積麻衣, 中島公平, 大野卓也, 郷司彩, 森達夫, 森健治, 髙木康志 :
けいれん重積型急性脳症に類似した症状を呈し，West症候群に移行した乳児頭部外傷の1例,
第50回日本小児神経外科学会, 2022年6月. 山本雄貴, 山本伸昭, 兼松康久, 黒田一駿, 藤田浩司, 髙木康志, 和泉唯信 :
徳島市におけるアプリケーションを用いた病院前脳主幹動脈閉塞診断スケールの活用,
第63回日本神経学会学術大会, 2022年5月. 山本伸昭, 黒田一駿, 山本雄貴, 兼松康久, 森垣龍馬, 和泉唯信, 髙木康志 :
脳主幹動脈閉塞に対する血行再建術において有効再開通が得られた患者の予後関連因子,
第63回日本神経学会学術大会, 2022年5月. 髙木康志 :
もやもや病の日本脳卒中学会登録事業,
第47回日本脳卒中学会学術集会WebLiveSymposium6, 2022年4月. 原慶次郎, 溝渕佳史, 安積麻衣, 曽我部周, 藤原敏孝, 中島公平, 髙木康志 :
Hyper vascularityを呈した松果体部腫瘍の1例,
第93回日本脳神経外科学会中国四国支部学術集会, 2022年4月. 髙木康志 :
STA-MCA bypassのエビデンスと基本手技(もやもや病を中心に),
第51回日本脳卒中の外科学会, 2022年3月. 髙木康志 :
もやもや病の日本脳卒中学会登録事業,
STROKE2022合同シンポジウム2, 2022年3月. 島田健司, 三宅一央, 山口泉, 宮本健志, 曽我部周, 兼松康久, 髙木康志 :
AVM摘出術における3D multimodal fusion imageとICG動注による術中videoangiography併用の有用性,
第51回日本脳卒中の外科学会学術集会, 2022年3月. 曽我部周, 兼松康久, 山口泉, 四方英二, 宮本健志, 島田健司, 山本雄貴, 山本伸昭, 髙木康志 :
open-cell stentにclosed-cell stentをオーバーラップさせたCASの治療成績,
STROKE2022, 2022年3月. 松田拓, 近藤心, 佐藤紀, 梅村公子, 曽我部周, 加藤真介, 兼松康久, 髙木康志 :
ロボットスーツHALの脳卒中急性期患者における即時効果の検討,
STROKE2022, 2022年3月. 平野愛子, 北村愛里, 重根裕代, 川原みゆき, 藤原敏孝, 多田恵曜, 森健治, 髙木康志 :
長時間ビデオ脳波モニタリング実施時の発作時観察力向上のための取り組み∼発作観察時のビデオ作成発作時対応のシミュレーションの実施∼.,
, 2022年3月. 兼松康久, 藤原敏孝, 島田健司, 多田恵曜, 髙木康志 :
外傷性内頚動脈海綿静脈洞瘻による静脈環流障害から非けいれん性てんかん重積をきたした一例,
第45回日本脳神経外傷学会, 2022年2月. 藤原敏孝, 多田恵曜, 片桐匡弥, 香川幸太, 飯田幸治, 髙木康志 :
比較的長時間持続する両側口角のけいれんを主とする薬剤抵抗性てんかんに対し迷走神経刺激療法を施行した1例,
第16回日本てんかん学会中国・四国地方会, 2022年2月. 三宅一央, 森垣龍馬, 牟礼英生, 松田拓, 後藤惠, 髙木康志 :
Vo-DBS施行後から9年経過したDYT6ジストニア患者の長期予後,
日本定位・機能神経外科学会機関紙, 2022年1月. 松田拓, 森垣龍馬, 松元友暉, 牟礼英生, 三宅一央, 中瀧理仁, 原田雅史, 髙木康志 :
全身性ジストニアと強迫性障害の重症度についての検討,
日本定位・機能神経外科学会機関紙, 2022年1月. 森垣龍馬, 藤川丈自, 松田拓, 三宅一央, 牟礼英生, 小田輝王, 宮本亮介, 藤田浩司, 山本伸昭, 和泉唯心, 髙木康志 :
特発性ジストニア患者の頭蓋骨の歪み,
日本定位・機能神経外科学会機関紙, 2022年1月. 松田拓, 森垣龍馬, 松元友暉, 牟礼英生, 三宅一央, 中瀧理仁, 原田雅史, 髙木康志 :
全身性ジストニアと強迫性障害の重症度についての検討,
第61回日本定位・機能神経外科学会, 2022年1月. 藤原敏孝, 多田恵曜, 髙木康志 :
迷走神経刺激装置交換時のリード損傷により全システムの交換を要した1例,
第45回日本てんかん外科学会, 2022年1月. 多田恵曜, 藤原敏孝, 鶴尾吉宏, 飯田幸治, 髙木康志 :
未固定遺体による半球離断術に対する手術トレーニング,
第45回日本てんかん外科学会, 2022年1月. 山口泉, 兼松康久, 島田健司, 山本伸昭, 曽我部周, 宮本健志, 石原学, 山本雄貴, 髙木康志 :
開頭下にLabbe静脈を直線穿刺することで治療し得たTSS d-AVFの1例,
近畿脳神経血管内手術法ワークショップ, 2022年1月. 山口泉, 兼松康久, 島田健司, 山本伸昭, 曽我部周, 宮本健志, 石原学, 山本雄貴, 髙木康志 :
開頭下にLabbe静脈の直線穿刺によるTVEを行ったTSS d-AVFの1例,
第92回日本脳神経外科学会中国四国支部会, 2021年12月. 曽我部周, 兼松康久, 山口泉, 四方英二, 宮本健志, 島田健司, 山本雄貴, 山本伸昭, 髙木康志 :
一期的にopen-cell stentにclosed-cell stentを重ねたCASの初期治療成績,
日本脳神経血管内治療学会, 2021年11月. 宮本健志, 曽我部周, 兼松康久, 四方英二, 山口泉, 石原学, 島田健司, 山本雄貴, 山本伸昭, 和泉唯信, 髙木康志 :
脳主幹動脈閉塞に対して急性期再開通療法後MRIのRibbon signの特徴,
日本脳神経血管内治療学会, 2021年11月. 髙木康志 :
脳卒中における地域連携と最新治療,
令和3年度「健康を考える県民のつどい」, 2021年11月. 髙木康志 :
AVMに対する治療選択と直達術の実際,
日本脳神経外科学会第80回学術総会, 2021年10月. 藤原敏孝, 多田恵曜, 溝渕佳史, 中島公平, 原慶次郎, 安積麻衣, 髙木康志 :
テント上髄膜腫手術症例におけるてんかん及び周術期発作管理の検討,
日本脳神経外科学会第80回学術総会, 2021年10月. 石原学, 兼松康久, 中西信人, 森垣龍馬, 山本伸昭, 大藤純, 獅々堀正幹, 髙木康志 :
日本ICU患者データベース(JIPAD)による急性期脳卒中症例の検討機械学習(データマイニング)を用いた解析,
日本脳神経外科学会学術総会, 2021年10月. 松田拓, 森垣龍馬, 松元友暉, 牟礼英生, 三宅一央, 中瀧理仁, 髙木康志 :
全身性ジストニアの重症度と強迫観念の関係性についての検討,
日本脳神経外科学会学術総会, 2021年10月. 三宅一央, 森垣龍馬, 牟礼英生, 髙木康志 :
DYT6ジストニア患者におけるDBS術後9年の長期予後,
日本脳神経外科学会学術総会, 2021年10月. 森垣龍馬, 藤川丈自, 小田輝王, 中西浩, 山本伸昭, 三宅一央, 松田拓, 髙木康志 :
機械学習を用いた脳線条体免疫染色画像の解析,
日本脳神経外科学会学術総会, 2021年10月. 多田恵曜, 藤原敏孝, 鶴尾吉宏, 髙木康志 :
未固定遺体によるてんかん外科に対する手術トレーニング,
NMC Case Report Journal, 2021年10月. 中島公平, 溝渕佳史, 藤原敏孝, 安積麻衣, 髙木康志 :
中枢神経原発悪性リンパ腫に対する大量メトトレキサート維持療法の意義,
NMC Case Report Journal, 2021年10月. 兼松康久, 金澤裕樹, 島田健司, 曽我部周, 宮本健志, 石原学, 四方英二, 山口泉, 多田恵曜, 山本雄貴, 山本伸昭, 原田雅史, 髙木康志 :
CEST MRIを用いた頚動脈プラーク診断 Chemical exchange saturation transfer MRI for carotid plaque imaging,
NMC Case Report Journal, 2021年10月. 島田健司, 三宅一央, 山口泉, 宮本健志, 曽我部周, 兼松康久, 髙木康志 :
AVM摘出術における3D multimodal fusion imageとICG動注による術中videoangiography併用の有用性,
NMC Case Report Journal, 2021年10月. 宮本健志, 山口泉, 四方英二, 石原学, 曽我部周, 島田健司, 兼松康久, 髙木康志 :
閉塞性血管障害に対する血行再建術後におけるArterial spin-labelingの変化,
NMC Case Report Journal, 2021年10月. 曽我部周, 兼松康久, 山口泉, 宮本健志, 島田健司, 山本雄貴, 山本伸昭, 髙木康志 :
当院でのopen-cell stentとclosed-cell stentの2枚重ねでのCASの治療成績,
NMC Case Report Journal, 2021年10月. 山口泉, 兼松康久, 島田健司, 山本伸昭, 宮本健志, 曽我部周, 石原学, 山本雄貴, 髙木康志 :
硬膜動静脈瘻の診断におけるArterial spin-labelingの有用性の検討 Usefulness of Arterial Spin-Labeling for diagnosis of dural arteriovenous fistulae,
日本脳神経外科学会第80回学術総会, 2021年10月. 森垣龍馬, 四方英二, 三宅一央, 松田拓, 髙木康志 :
神経刺激装置埋め込み術後の皮下血腫に対し漢方薬が奏功した3例,
第29回日本脳神経外科漢方医学会学術集会, 2021年10月. 髙木康志 :
脳卒中治療GL2021改訂と出血型脳血管障害の最新治療,
脳卒中治療GL WEBセミナー, 2021年9月. 山本伸昭, 山本雄貴, 黒田一駿, 山口泉, 曽我部周, 島田健司, 兼松康久, 和泉唯信, 髙木康志 :
脳主幹動脈閉塞における有効再開通が得られた患者における予後関連因子,
第23回中国四国脳卒中研究会, 2021年9月. 安積麻衣, 宮本健志, 藤原敏孝, 中島公平, 原慶次郎, 溝渕佳史, 髙木康志 :
特発性頭蓋内圧亢進様の症状のみで発症した小児脳腫瘍の1例,
第35回中国四国脳腫瘍研究会, 2021年9月. 多田恵曜, 藤原敏孝, 鶴尾吉宏, 飯田幸治, 髙木康志 :
未固定遺体による半球離断術に対する手術トレーニング,
第54回日本てんかん学会学術集会, 2021年9月. 髙木康志 :
脳卒中治療ガイドライン2021(脳出血を中心に),
第48回日本脳神経看護研究学会, 2021年9月. 安積麻衣, 牟礼英生, 髙木康志 :
広範な硬膜欠損に対して吸収性コラーゲン人工硬膜を用いて髄液漏を防ぎ得た脊髄髄膜瘤の1例,
第49回日本小児神経外科学会, 2021年6月. 山本雄貴, 山本伸昭, 黒田一駿, 山口泉, 宮本健志, 島田健司, 髙木康志, 和泉唯信 :
血栓回収療法におけるFirst Pass Effect達成を予測する画像因子の探索,
第62回日本神経学会学術大会, 2021年5月. 髙木康志 :
脳血管外科手術における術前シミュレーションの重要性,
第30回脳神経外科手術と機器学会, 2021年4月. 髙木康志 :
脳動脈奇形の基礎研究と外科治療,
脳卒中治療ExpertMeeting, 2021年4月. 島田健司, 山本陽子, 山口泉, 宮本健志, 曽我部周, 兼松康久, 髙木康志 :
AVM摘出術におけるHybrid手術室でのインドシアニン・グリーン動注による術中videoangiographyの有用性,
第44回日本脳神経Cl学会総会, 2021年4月. 原慶次郎, 溝渕佳史, 安積麻衣, 中島公平, 髙木康志 :
AIDS関連トキソプラズマ脳症の1例,
第91回(一社)日本脳神経外科学会中国四国支部学術集会, 2021年4月. 髙木康志 :
脳卒中ガイドライン2021「脳出血」,
Stroke2021, 2021年3月. 髙木康志 :
脳卒中の外科技術認定制度準拠・マイクロ手術道場2「脳動静脈奇形」,
第50回日本脳卒中の外科学会学術集会, 2021年3月. 島田健司, 山口泉, 宮本健志, 曽我部周, 花岡真実, 兼松康久, 松﨑和仁, 佐藤浩一, 髙木康志 :
海綿静脈洞部硬膜動静脈瘻におけるshunted pouchと頭蓋底骨の関係,
第46回日本脳卒中学会学術集会, 2021年3月. 兼松康久, 島田健司, 曽我部周, 宮本健志, 石原学, 山口泉, 山本雄貴, 山本伸昭, 髙木康志 :
当施設における巨大血栓化脳動脈瘤に対する治療成績,
第46回日本脳卒中学会学術集会, 2021年3月. 宮本健志, 曽我部周, 兼松康久, 島田健司, 山口泉, 山本伸昭, 山本雄貴, 和泉唯信, 髙木康志 :
脳梗塞急性期再開通療法後MRIの急性期ribbon signの特徴,
第46回日本脳卒中学会学術集会, 2021年3月. 松田拓, 安積麻衣, 鹿草宏, 佐藤紀, 梅村公子, 加藤真介, 髙木康志 :
脊髄海綿状血管腫摘出術後にHALを用いたリハビリテーションを行い良好な転帰が得られた一例,
第9回日本脳神経HAL研究会, 2021年2月. 多田恵曜, 藤原敏孝, 佐藤裕一, 飯田幸治, 髙木康志 :
2期的に半球離断術を施行した成人片側巨脳症の1例,
第15回日本てんかん学会中国・四国地方会, 2021年2月. 石原学, 中西信人, 兼松康久, 森垣龍馬, 山本伸昭, 髙木康志, 大藤純 :
日本ICU患者データベース(JIPAD)による急性期脳卒中症例の検討,
日本集中治療医学会雑誌, 2021年2月. 森垣龍馬, 牟礼英生, 松田拓, 三宅一央, 宮本亮介, 藤田浩司, 中瀧理仁, 梶龍兒, 髙木康志, 後藤惠 :
機能ー器質ボーダーラインジストニアに対する脳深部刺激療法,
第60回日本定位・機能神経外科学会, 2021年1月. 牟礼英生, 森垣龍馬, 小山広士, 三宅一央, 松田拓, 宮本亮介, 藤田浩司, 和泉唯信, 後藤惠, 髙木康志 :
遅発性ジストニアに対する淡蒼球内節刺激術12例の検討ー適応・長期成績・刺激条件についてー,
第60回日本定位・機能神経外科学会, 2021年1月. 三宅一央, 松田拓, 森垣龍馬, 牟礼英生, 髙木康志, 宮本亮介 :
ジストニックストームを生じたGNAO1遺伝子変異に対し淡蒼球脳深部刺激療法を行った1例,
第60回日本定位・機能神経外科学会, 2021年1月. 松田拓, 松元友暉, 森垣龍馬, 牟礼英生, 三宅一央, 加藤真介, 尾藤良孝, 原田雅史, 髙木康志 :
Quantitative parameter mappingを用いた3TMRIでの視床下核の可視化,
第60回日本定位・機能神経外科学会, 2021年1月. 石原学, 竹村星哉, 兼松康久, 森垣龍馬, 山本伸昭, 大藤純, 大野将樹, 獅々堀正幹, 髙木康志 :
機械的学習を用いた医療データの解析脳出血症例の検討,
第79回日本脳神経外科学会学術総会, 2020年10月. 牟礼英生, 森垣龍馬, 小山広士, 大北真哉, 松田拓, 佐光亘, 宮本亮介, 藤田浩司, 和泉唯信, 梶龍兒, 後藤惠, 髙木康志 :
遅発性ジストニアに対する淡蒼球内節刺激術12例の検討:適応・長期成績・刺激条件について,
第79回日本脳神経外科学会総会, 2020年10月. 柿原紋太, 野崎夏江, 兼本ひろみ, 津田恵, 山本恭代, 山本雄貴, 山本伸昭, 石原学, 島田健司, 兼松康久, 西京子, 加藤真介, 髙木康志 :
徳島大学病院脳卒中センター(SCU)における排尿ケアチーム介入後の下部尿路機能障害の現状,
第45回日本脳卒中学会総会(web開催), 2020年8月. 藤原敏孝, 多田恵曜, 島田健司, 兼松康久, 髙木康志 :
内頚動脈海綿静脈洞瘻に急性症候発作重積を合併した1例,
第14回日本てんかん学会中国・四国地方会, 2020年2月. 藤原敏孝, 多田恵曜, 安積麻衣, 髙木康志 :
海馬からのてんかん性放電が乏しかった海馬硬化症の1例,
第7回全国てんかんセンター協議会広島大会, 2020年2月. 多田恵曜, 東田好広, 中瀧理仁, 藤原敏孝, 森達夫, 郷司彩, 飯田幸治, 森健治, 髙木康志 :
徳島県におけるてんかん地域診療連携整備事業の活動状況,
第7回全国てんかんセンター協議会広島大会, 2020年2月. 石原学, 兼松康久, 山本伸昭, 曽我部周, 宮本健志, 島田健司, 山本雄貴, 大藤純, 髙木康志 :
NIHSS5点以下軽症脳主幹動脈閉塞症例における転帰,
第25回日本脳神経外科救急学会, 2020年2月. 多田恵曜, 藤原敏孝, 香川幸太, 片桐匡弥, 瀬山剛, 飯田幸治, 髙木康志 :
遠隔てんかん症例検討会による薬剤抵抗性側頭葉てんかん治療方針の決定について,
第43回日本てんかん外科学会, 2020年1月. 松田拓, 森垣龍馬, 牟礼英生, 中瀧理仁, 山本陽子, 豊田直人, 後藤惠, 髙木康志 :
ジストニアと強迫性障害の関係についての検討,
機能的脳神経外科, 130, 2020年1月. 牟礼英生, 藤田浩司, 森垣龍馬, 宮本亮介, 松田拓, 後藤惠, 髙木康志, 後藤惠 :
FDG PETを用いたジストニア患者の脳代謝ネットワークパターンの描出,
機能的脳神経外科, 132, 2020年1月. 森垣龍馬, 牟礼英生, 松田拓, 宮本亮介, 山本陽子, 豊田直人, 髙木康志, 後藤惠 :
GPi-DBSを施行したDYT-GNAL(DYT25)の一例,
機能的脳神経外科, 134, 2020年1月. 藤原敏孝, 多田恵曜, 兼松康久, 髙木康志 :
Wadatestにて言語優位半球を同定できなかった薬剤抵抗性側頭葉てんかんの一例,
第43回日本てんかん外科学会, 2020年1月. 山本陽子, 兼松康久, 曽我部周, 宮本健志, 高麗雅章, 島田健司, 髙木康志 :
Neckからfetal typeのPcomが起始する大型血栓化IC-PC動脈瘤に対しステント併用下コイル塞栓術を行った一例,
第88回(一社)日本脳神経外科学会中国四国支部学術集会, 2019年12月. 山口真司, 宮本健志, 北里慶子, 四方英二, 山口泉, 高麗雅章, 島田健司, 多田恵曜, 兼松康久, 髙木康志 :
エストロゲン欠乏脳動脈瘤ラットモデルにおけるERαの低下とNLRP3 inflammasome活性の関係,
第62回日本脳循環代謝学会学術集会, 2019年11月. 山本雄貴, 山本伸昭, 兼松康久, 石原学, 宮本健志, 高麗雅章, 島田健司, 牟礼英生, 髙木康志, 和泉唯信 :
転倒後の脳脊髄液減少症に上矢状静脈洞血栓症を合併し, 血管内治療をおこなった一例,
第35回日本脳神経血管内治療学会学術総会, 2019年11月. 島田健司, 佐藤浩一, 松田拓, 宮本健志, 高麗雅章, 兼松康久, 髙木康志 :
Targeting‌embolizationを行わず，流出路をコイル塞栓することにより舌下神経障害なく治療し得た‌ACC‌dAVFの1例,
第35回日本脳神経血管内治療学会学術総会, 2019年11月. 兼松康久, 島田健司, 高麗雅章, 宮本健志, 多田恵曜, 山本雄貴, 山本伸昭, 里見淳一郎, 髙木康志 :
当院での急性期脳底動脈閉塞に対する血管内治療成績,
第35回日本脳神経血管内治療学会学術総会, 2019年11月. 山本雄貴, 山本伸昭, 福本竜也, 村上永久, 宮本亮介, 藤田浩司, 牟礼英生, 兼松康久, 髙木康志, 和泉唯信 :
転倒を契機に脳脊髄液減少症と静脈洞血栓症を合併し，ブラッドパッチにて治療した脊髄小脳変性症6型の1例,
第37回日本神経治療学会学術集会, 2019年11月. 藤原敏孝, 多田恵曜, 溝渕佳史, 中島公平, 安積麻衣, 髙木康志 :
脳腫瘍手術における周術期抗てんかん薬使用と術後発作抑制効果についての検討,
第53回日本てんかん学会学術集会, 2019年10月. 多田恵曜, 東田好広, 中瀧理仁, 藤原敏孝, 森達夫, 郷司彩, 飯田幸治, 森健治, 髙木康志 :
徳島県におけるてんかん地域診療連携整備事業の紹介,
第53回日本てんかん学会学術集会, 2019年10月. 筑後桃子, 鈴木佳子, 西京子, 髙木康志, 濵田康弘 :
当院脳卒中センター(SCU)における栄養サポートチーム(NST)の取り組み―2017年度・2018年度の比較―,
第11回日本静脈経腸栄養学会四国支部会学術集会, 2019年10月. 森垣龍馬, 牟礼英生, 宮本亮介, 松田拓, 山本陽子, 髙木康志, 後藤惠 :
機能性ジストニアは器質性ジストニアスペクトラム障害か?,
Neurologia Medico-Chirurgica, 349, 2019年10月. 松田拓, 島田健司, 宮本健志, 阿部考志, 高麗雅章, 兼松康久, 髙木康志 :
T1-CUBEが有効であった頭蓋内動脈解離の2例,
日本脳神経外科学会第78回学術集会, 2019年10月. 鹿草宏, 溝渕佳史, 藤原敏孝, 中島公平, 髙木康志 :
眼窩内に転移した子宮頚癌の1例,
日本脳神経外科学会第78回学術集会, 2019年10月. 石原学, 兼松康久, 山本伸昭, 宮本健志, 高麗雅章, 島田健司, 山本雄貴, 大藤純, 髙木康志 :
NIHSS 5点以下の軽症脳主幹動脈閉塞症例における予後因子,
日本脳神経外科学会第78回学術集会, 2019年10月. 山口真司, 宮本健志, 北里慶子, 四方英二, 山口泉, 高麗雅章, 島田健司, 多田恵曜, 兼松康久, 髙木康志 :
脳動脈瘤破裂モデルにおける部位特異的な早期形態変化と血管崩壊関連分子の変動,
日本脳神経外科学会第78回学術集会, 2019年10月. 中島公平, 藤原敏孝, 溝渕佳史, 髙木康志 :
当院における転移性脳腫瘍に対する術後放射線療法の検討,
日本脳神経外科学会第78回学術集会, 2019年10月. 多田恵曜, 藤原敏孝, 中島公平, 安積麻衣, 髙木康志 :
高齢発症てんかんの臨床的特徴,
日本脳神経外科学会第78回学術集会, 2019年10月. 兼松康久, 島田健司, 高麗雅章, 宮本健志, 山口泉, 山口真司, 多田恵曜, 里見淳一郎, 永廣信治, 髙木康志 :
当院における急性期脳底動脈閉塞に対する治療成績,
日本脳神経外科学会第78回学術集会, 2019年10月. 牟礼英生, 藤田浩司, 森垣龍馬, 宮本亮介, 後藤惠, 髙木康志 :
FDG PETを用いたジストニア患者の脳代謝ネットワークパターンの描出,
日本脳神経外科学会第78回学術集会, 2019年10月. 宮本健志, 北里慶子, 多田恵曜, 島田健司, 高麗雅章, 山口真司, 兼松康久, 髙木康志 :
Porphyromonas gingivalis LPSは脳動脈瘤モデルラットにおいて脳動脈瘤破裂を促進する,
日本脳神経外科学会第78回学術集会, 2019年10月. 藤原敏孝, 溝渕佳史, 中島公平, 安積麻衣, 多田恵曜, 髙木康志 :
脳腫瘍手術における周術期抗てんかん薬使用の現状,
Neurologia Medico-Chirurgica, 2019年10月. 山口泉, 兼松康久, 島田健司, 高麗雅章, 宮本健志, 北里慶子, 山本伸昭, 山本雄貴, 髙木康志 :
院内発症脳梗塞の転帰不良に関連する因子の検討,
Neurologia Medico-Chirurgica, 2019年10月. 松元友暉, 金澤裕樹, 金城祐奎, 原田雅史, 阿部考志, 兼松康久, 髙木康志 :
頸動脈狭窄の定量評価を目的とした4D-flow流体解析,
第1回 4D FLOW研究会, 2019年9月. 山本伸昭, 山本雄貴, 石原学, 宮本健志, 島田健司, 兼松康久, 和泉唯信, 髙木康志 :
血行再建術前における経静脈的造影剤投与によるFlat panel CTAの有用性,
中四国脳卒中研究会, 2019年9月. 髙木康志 :
High grade脳動静脈奇形に対する外科的治療の現状,
第22回日本臨床脳神経外科学会シンポジウム, 2019年7月. 山本伸昭, 黒田一駿, 山本雄貴, 石原学, 高麗雅章, 島田健司, 兼松康久, 和泉唯信, 髙木康志 :
Tandem Occlusion患者に対する血管内治療(Simultaneous Approach),
第44回日本脳卒中学会学術集会, 2019年3月. 髙木康志 :
もやもや病の治療と高次脳機能,
第48回日本脳卒中の外科学会シンポジウム, 2019年3月. 山本雄貴, 山本伸昭, 黒田一駿, 高麗雅章, 岡﨑敏之, 島田健司, 兼松康久, 和泉唯信, 髙木康志 :
血栓回収療法後の造影剤腎症は白血球数高値と関連する,
第44回日本脳卒中学会学術集会, 2019年3月. 髙木康志 :
STA-MCA bypass,
第48回日本脳卒中の外科学会技術認定医養成講座「脳卒中の外科をマスターしよう」, 2019年3月. 筑後桃子, 西麻希, 菊井聡子, 松村晃子, 兼本ひろみ, 岩野朝香, 高野栄之, 佐藤紀, 加藤真介, 西京子, 山本伸昭, 兼松康久, 髙木康志, 濵田康弘 :
当院脳卒中センター(SCU)入院患者における栄養管理―栄養サポートチーム(NST)の取り組み―,
日本脳卒中学会2019, 2019年3月. 西京子, 兼松康久, 高麗雅章, 岡﨑敏之, 島田健司, 山本伸昭, 高野栄之, 加藤真介, 髙木康志 :
徳島大学病院脳卒中センター (SCU)の多職種連携による医療人育成,
日本脳卒中学会2019, 2019年3月. 山本雄貴, 山本伸昭, 黒田一駿, 福本竜也, 石原学, 高麗雅章, 島田健司, 兼松康久, 和泉唯信, 髙木康志 :
治療後に症状増悪した上矢状静脈洞血栓症の一例,
第8回脳血管内治療四国遍路塾, 2019年3月. 山本雄貴, 黒田一駿, 山本伸昭, 鹿草宏, 高麗雅章, 島田健司, 兼松康久, 和泉唯信, 髙木康志 :
頭癌治療中に内頚動脈閉塞を認めた1例,
第21回徳島脳血管障害カンファレンス, 2019年3月. 髙木康志 :
脳神経外科における手術の進歩と機能的脳神経外科,
国立病院機構宇多野病院講演, 2019年3月. 山本雄貴, 山本伸昭, 黒田一駿, 高麗雅章, 岡﨑敏之, 島田健司, 兼松康久, 和泉唯信, 髙木康志 :
塞栓回収療法後の造影剤腎症についての検討,
第21回徳島脳卒中研究会, 2019年2月. 中島公平, 藤原敏孝, 溝渕佳史, 髙木康志 :
中枢神経原発性悪性リンパ腫に対する大量メトトレキサート維持療法の治療成績,
第36回日本脳腫瘍学会学術集会, 2018年12月. 高麗雅章, 里見淳一郎, 山本雄貴, 山本伸昭, 岡﨑敏之, 島田健司, 兼松康久, 髙木康志 :
Borden type 1横・S状静脈洞部硬膜動静脈瘻に対するバルーン支援下選択的経静脈塞栓術,
第34回日本脳神経血管内治療学会学術総会, 2018年11月. 島田健司, 大谷誠, 兼松康久, 髙木康志 :
DPCを用いた疫学的調査による我が国の硬膜動静脈瘻の現状,
第34回日本脳神経血管内治療学会学術総会, 2018年11月. 中島公平, 藤原敏孝, 溝渕佳史, 髙木康志 :
穿刺様頭痛で発見された中枢神経アスペルギルス症の1例,
第46回日本頭痛学会総会, 2018年11月. 髙木康志 :
脳動静脈奇形手術における出血コントロールの重要性,
第77回日本脳神経外科学会総会, 2018年10月. 髙木康志 :
脳動静脈奇形に対する治療の最前線,
第77回日本脳神経外科学会総会, 2018年10月. 島田健司, 佐藤裕一, 羽星辰哉, 花岡真実, 仁木均, 松﨑和仁, 佐藤浩一, 三宅一, 髙木康志 :
急性期脳梗塞に対するstent retrieverと吸引カテーテルを併用した血栓回収療法―従来の治療法との比較検討―,
日本脳神経外科学会第77回学術総会, 2018年10月. 高麗雅章, 里見淳一郎, 兼松康久, 牟礼英生, 島田健司, 岡﨑敏之, 髙木康志 :
硬膜動静脈瘻に対する直達術,
日本脳神経外科学会第77回学術総会, 2018年10月. 四方英二, 田村哲也, 新野清人, 篠原直樹, 兼松康久, 髙木康志 :
くも膜下出血術後管理のTips 水―ナトリウムバランスを少量投与で個別管理する重要性,
日本脳神経外科学会第77回学術総会, 2018年10月. 牟礼英生, 宮本亮介, 大北真哉, 梶龍兒, 後藤惠, 永廣信治, 髙木康志 :
小児期ジストニアに対する脳深部刺激療法の適応と予後について,
日本脳神経外科学会第77回学術総会, 2018年10月. 兼松康久, 島田健司, 高麗雅章, 岡﨑敏之, 多田恵曜, 里見淳一郎, 永廣信治, 髙木康志 :
当院における高齢者(80歳以上)くも膜下出血の治療成績と予後の検討,
日本脳神経外科学会第77回学術総会, 2018年10月. 岡﨑敏之, 兼松康久, 島田健司, 高麗雅章, 里見淳一郎, 宇野昌明, 髙木康志 :
当院におけるhemashield patchを使用した頸動脈内膜剥離術の長期成績の検討,
日本脳神経外科学会第77回学術総会, 2018年10月. 里見淳一郎, 吉岡正太郎, 宮本健志, 成石浩司, 北里慶子, 多田恵曜, 原田雅史, 髙木康志, 永廣信治 :
脳動脈瘤と歯周病との関連,
日本脳神経外科学会第77回学術総会, 2018年10月. 髙木康志 :
脳神経外科手術における出血コントロールの重要性,
日本脳神経外科学会第77回学術総会, 2018年10月. 多田恵曜, 藤原敏孝, 中島公平, 森健治, 髙木康志 :
高齢発症てんかんの臨床的特徴，新規抗てんかん薬の効果,
日本脳神経外科学会第77回学術総会, 2018年10月. 藤原敏孝, 溝渕佳史, 中島公平, 岡﨑敏之, 牟礼英生, 髙木康志 :
膠芽腫におけるDKK3遺伝子導入による薬剤排泄ポンプの発現抑制の意義,
日本脳神経外科学会第77回学術総会, 2018年10月. 鹿草宏, 溝渕佳史, 藤原敏孝, 中島公平, 髙木康志 :
慢性硬膜下血腫の手術方法の検討,
日本脳神経外科学会第77回学術総会, 2018年10月. 中島公平, 藤原敏孝, 溝渕佳史, 髙木康志 :
当院における中枢神経原発悪性リンパ腫に対する大量メトトレキサート維持療法の治療成績,
日本脳神経外科学会第77回学術総会, 2018年10月. 溝渕佳史, 中島公平, 藤原敏孝, 永廣信治, 髙木康志 :
顔面痙攣に対する手術手技 "shelter method" の有効性と長期予後,
日本脳神経外科学会第77回学術総会, 2018年10月. 畠田昇一, 小山広士, 藤原敏孝, 中島公平, 溝渕佳史, 髙木康志 :
短期間で出血を繰り返した多発脳病変の1例,
第32回中国四国脳腫瘍研究会, 2018年9月. 高麗雅章, 羽星辰哉, 山本雄貴, 山本伸昭, 岡﨑敏之, 島田健司, 兼松康久, 髙木康志 :
脳腫瘍との鑑別を要した海綿静脈胴部硬膜動静脈瘻の一例,
脳血管内治療ブラッシュアップセミナー2018, 2018年9月. 筑後桃子, 松村晃子, 西京子, 髙木康志, 濵田康弘 :
当院SCU入院患者における栄養管理―NSTの取り組み―,
第10回日本静脈経腸栄養学会四国支部会学術集会, 2018年9月. 筑後桃子, 松村晃子, 西京子, 髙木康志, 濵田康弘 :
当院SCU入院患者における栄養管理―NST及び地域とのかかわりについて―,
第2回徳島県地域包括ケアシステム学会, 2018年8月. 牟礼英生, 岡﨑敏之, 髙木康志 :
パーキンソン病患者の腰痛に対する脊髄刺激療法の長期成績,
第33回日本脊髄外科学会, 2018年6月. 髙木康志 :
脳動脈奇形治療のエビデンスとリアルワールド,
第38回日本脳神経外科コングレス総会, 2018年5月. 髙木康志 :
脳動静脈奇形の基礎研究と外科的治療,
第94回日本脳神経外科学会中部支部学術集会ランチョンセミナー, 2018年4月. 羽星辰哉, 高麗雅章, 牟礼英生, 兼松康久, 里見淳一郎, 髙木康志 :
頭蓋内出血で発症した蝶形骨小翼部硬膜動静脈瘻の1例,
第85回日本脳神経外科学会中国四国支部学術集会, 2018年4月. 髙木康志 :
脳動静脈奇形の基礎研究と外科的治療の現状,
第47回日本脳卒中の外科学会ランチョンセミナー, 2018年3月. 四方英二, 髙木康志, 兼松康久, 田村哲也, 新野清人, 篠原直樹 :
くも膜下出血の術後管理24症例の検討,
第43回日本脳卒中学会学術集会, 2018年3月. 高麗雅章, 山口泉, 多田恵曜, 兼松康久, 里見淳一郎, 山本伸昭, 山本雄貴, 髙木康志 :
地方国立大学病院における院内発症脳卒中症例の特徴,
第43回日本脳卒中学会学術集会, 2018年3月. 高麗雅章, 里見淳一郎, 山口泉, 兼松康久, 山本伸昭, 山本雄貴, 髙木康志 :
病型別にみた急性期脳主幹動脈閉塞に対する再開通療法,
第47回日本脳卒中の外科学会学術集会, 2018年3月. 兼松康久, 高麗雅章, 宇野昌明, 永廣信治, 髙木康志 :
PICA involved type の破裂椎骨動脈解離に対し，解離部の盲端化を行った4症例の検討,
第47回日本脳卒中の外科学会学術集会, 2018年3月. 髙木康志 :
Spetzler-Martin grade 2，3脳動静脈奇形に対する外科治療,
第47回日本脳卒中の外科学会学術集会, 2018年3月. 庄野健児, 里見淳一郎, 多田恵曜, 兼松康久, 山本伸昭, 和泉唯信, 梶龍兒, 原田雅史, 永廣信治, 髙木康志 :
Optimal timing of DWI to avoid false-negative findings in patients with TIA,
第41回日本脳神経CI学会総会, 2018年3月. Yasushi Takagi :
Microvascular anastomosis for moyamoya disease,
4th Winter Seminar on Cerebrovascular Diseases(CVD), Feb. 2018. Yasushi Takagi :
Current status of surgical treatment against brain arteriovenous malformations,
4th Winter Seminar on Cerebrovascular Diseases(CVD), Feb. 2018. 牟礼英生, 森垣龍馬, 宮本亮介, 中瀧理仁, 髙木康志, 梶龍兒, 永廣信治, 後藤惠 :
ジストニアDBS治療における多職種連携．,
第57回日本定位・機能神経外科学会, 2018年1月. 牟礼英生, 森垣龍馬, 宮本亮介, 中瀧理仁, 岡久哲也, 髙木康志, 梶龍兒, 永廣信治, 後藤惠 :
ジストニアDBS治療における多職種連携,
第57回日本定位・機能神経外科学会, 2018年1月. 多田恵曜, 藤原敏孝, 郷司彩, 森達夫, 東田好広, 森健治, 飯田幸治, 里見淳一郎, 髙木康志 :
術前精査中にバルブロ酸の追加が著効したrolandic crtical dysplasiaに1例,
第41回日本てんかん外科学会, 2018年1月. 羽星辰哉, 髙木康志 :
急性硬膜下血腫で発症した中大脳動脈瘤の一例,
第29回石打カンファレンス, 2018年1月. 髙木康志 :
Spetzler-Martin Grade Ⅰ-Ⅱの脳動静脈奇形に対する外科治療,
第29回石打カンファレンス, 2018年1月. 高麗雅章, 山本雄貴, 山口泉, 山本伸昭, 兼松康久, 髙木康志 :
当院の急性期主幹動脈閉塞に対する再開通療法の治療成績 -病型分類別にみた特徴-,
第33回NPO法人日本脳神経血管内治療学会学術総会, 2017年11月. 高麗雅章, 里見淳一郎, 木内智也, 山本雄貴, 山口泉, 山本伸昭, 兼松康久, 髙木康志 :
病型別にみた急性期脳動脈閉塞に対する再開通療法の治療成績,
日本脳神経外科学会第76回学術総会, 2017年10月. 髙木康志, 西秀久, 田中浩基, 南角学, 高橋由紀, 菊池隆幸, 武信洋平, 荒川芳輝, 吉田和道, 宮本享 :
HALを用いた治療の現状と今後の展開,
第8回ニューロリハビリテーション学会, 2017年4月.

研究会・報告書: 髙木康志 :
『How to do it これをどう治すのか』,
Direct Neurosurgery Technical Conference 2023, 2023年12月. 安積麻衣, 中島公平, 藤原敏孝, 原慶次郎, 髙木康志 :
リツシマブ併用大量療法が奏功した難治性中枢神経原発悪性リンパ腫の1例,
第37回中四国脳腫瘍研究会, 2023年9月. 髙木康志 :
脳血管障害に対する外科的治療の現状,
Stroke手術手技セミナーin岡山, 2023年2月. 髙木康志 :
脳動静脈奇形に対する安全な外科的治療,
第2回Stroke手術手技セミナーin北海道, 2023年1月. 髙木康志 :
脳動静脈奇形の基礎研究と外科治療,
西尾久ニューロカンファ2022, 2022年12月. 髙木康志 :
脳卒中治療GL2021改訂と出血型脳血管障害の最新治療,
脳卒中トータルケアセミナー, 2022年7月. 髙木康志 :
もやもや病の現状,
もやもや病全国多会場同時市民公開講座, 2022年6月. 髙木康志 :
脳卒中治療ガイドライン2021改訂と脳卒中地域連携について,
第3回BrainSeminar, 2022年3月. 髙木康志 :
脳動静脈奇形の基礎研究と外科治療,
名古屋脳血管外科セミナー, 2022年3月. 松田拓, 近藤心, 川村由佳, 佐藤紀, 梅村公子, 西良浩一, 兼松康久, 髙木康志 :
脳卒中急性期患者におけるロボットスーツHALによる即時効果の検討,
第10回HAL研究会, 2021年12月. 松田拓, 鹿草宏, 梅村公子, 佐藤紀, 森垣龍馬, 牟礼英生, 兼松康久, 松元友暉, 原田雅史, 加藤真介, 髙木康志 :
ロボットスーツHALを用いた脳卒中急性期リハビリテーションの当院での取り組み,
第8回日本脳神経HAL研究会, 2020年2月. 山口真司, 宮本健志, 曽我部周, 佐藤紀, 兼松康久, 髙木康志 :
二期的に治療を行った左中大脳動脈の巨大血栓化動脈瘤の1例,
第31回石打カンファランス, 2020年2月. 髙木康志 :
もやもや病の治療について,
難病医療講演会・相談会, 2019年11月. 髙木康志 :
もやもや病の現状について,
第15回「もやの会」四国ブロック愛媛集会, 2019年11月. 髙木康志 :
脳動静脈奇形の基礎研究と外科治療,
第6回明石子午線神経科学カンファレンス, 2019年11月. 髙木康志 :
脳死の病態について,
徳島県5類型施設研修会, 2019年11月. 髙木康志 :
脳卒中を防ぐために,
第12回HITO病院地域医療講演会, 2019年10月. 髙木康志 :
脳卒中における外科的治療の現状-抗血栓療法も含めて-,
第30回徳島脳卒中シームレスケア研究会, 2019年9月. 髙木康志 :
脳卒中の予防と治療,
第一回四国中央医療セミナー, 2019年9月. 髙木康志 :
脳動静脈奇形の基礎研究と外科的治療,
第23回四国脳神経外科カンファレンス, 2019年9月. 髙木康志 :
脳卒中に対する外科治療の現状と未来,
第28回日本脳神経看護研究学会四国部会, 2019年7月. 髙木康志 :
脳動静脈奇形の基礎研究と外科的治療,
第49回兵庫県脳神経外科医懇話会, 2019年7月. 髙木康志 :
脳動静脈奇形の基礎研究と外科的治療,
第10回 SPEC-UP meeting, 2019年7月. 髙木康志 :
脳動静脈奇形の基礎研究と外科的治療抗凝固薬による治療も含めて,
第115回大阪脳神経外科研究会, 2019年7月. 髙木康志 :
徳島大学脳神経外科における外科治療の現状,
蘊奥倶楽部2019, 2019年7月. 髙木康志 :
徳島大学における脳動静脈奇形の手術,
第6回フロンティアミーティング, 2019年6月. 髙木康志 :
脳卒中の予防と治療,
三好市医師会学術講演会, 2019年5月. 髙木康志 :
脳動静脈奇形の基礎研究と外科的治療-抗凝固薬による治療も含めて-脳卒中治療,
Up to date, 2019年5月. 髙木康志 :
CEA・脳虚血,
第17回脳神経外科勉強会, 2019年5月. 髙木康志 :
脳動静脈奇形に対する外科治療の現状,
第23回関西脳神経外科手術研究会, 2018年12月. 髙木康志 :
出血型脳血管障害の基礎研究と外科的治療-めまいとの関連も含めて-,
第24回広島県めまい研究会, 2018年12月. 鹿草 (名), 松田拓, 石原学, 高麗雅章, 岡﨑敏之, 島田健司, 兼松康久, 髙木康志 :
くも膜下出血で発症した，前方循環系の動脈解離,
第44回徳島脳神経外科談話会, 2018年12月. 髙木康志 :
脳動静脈奇形の基礎研究と外科的治療,
札幌脳機能画像講演会2018, 2018年11月. 髙木康志 :
脳動静脈奇形に対する外科治療の現状,
第8回Takamatsu-Kyoto Friendship Conference, 2018年11月. 髙木康志 :
脳動静脈奇形の基礎研究と外科的治療,
第12回大阪CVD研究会, 2018年11月. 髙木康志 :
徳島大学脳神経外科の新展開,
Nara-Kyoto Friendship Conference, 2018年11月. 髙木康志 :
脳血管障害に対する外科治療の現状と未来,
第269回名西郡・徳島西医師会学術講演会, 2018年8月. 髙木康志 :
脳卒中を防ぐために,
善通寺市民健康講座, 2018年7月. 髙木康志 :
脳動静脈奇形の基礎研究と外科的治療,
第38回CVD-TRAK Meeting, 2018年7月. 髙木康志 :
脳血管障害に対する外科治療の現状と未来,
ストップ!NO卒中エリア会議in米子, 2018年7月. 髙木康志 :
脳血管障害に対する外科治療の現状と未来,
Stroke Conference∼急性期から回復期を考える∼, 2018年7月. 髙木康志 :
脳神経外科領域における術中画像の有用性,
第10回徳島Vascular Imaging研究会, 2018年7月. 髙木康志 :
脳卒中を防ぐには,
名西郡医師会町民健康講座, 2018年7月. 髙木康志 :
脳動脈奇形に対する外科治療の現状,
第5回脳神経外科フロンティアミーティング, 2018年6月. 髙木康志 :
脳動静脈奇形の基礎研究と外科的治療,
第11回瀬戸内脳神経外科研究会, 2018年6月. 髙木康志 :
脳虚血における神経幹細胞研究の歴史と現状,
第13回脳卒中エキスパートミーティング, 2018年4月. 高麗雅章, 里見淳一郎, 山本雄貴, 山本伸昭, 兼松康久, 髙木康志 :
二期的に治療した海綿静脈胴部硬膜動静脈瘻の1例,
第7回脳血管内治療四国遍路塾, 2018年3月. 高麗雅章, 里見淳一郎, 山本雄貴, 山口泉, 山本伸昭, 兼松康久, 髙木康志 :
頸動脈ステント留置術後10日目に過灌流による脳出血を来した1例,
第5回徳島脳疾患談話会, 2018年3月. 髙木康志 :
脳血管障害に対する外科治療の現状と未来,
徳島県脳卒中研究会, 2018年2月. 髙木康志 :
脳虚血における神経幹細胞研究の歴史と現状,
第20回徳島脳卒中研究会, 2018年2月. 筑後桃子, 松村晃子, 西京子, 髙木康志, 濵田康弘 :
当院SCU入院患者における栄養管理 ―NST及びチーム医療の取り組み―,
第20回脳卒中研究会, 2018年2月. 髙木康志 :
京都から徳島へ徳島大学脳神経外科の展望,
京都大学脳神経外科同門会, 2018年2月. 髙木康志 :
脳虚血における神経幹細胞研究の歴史と現状,
第177回宮城県脳卒中治療研究会, 2018年1月. 髙木康志 :
脳血管障害に対する外科治療の現状と未来,
徳島県臨床内科医会, 2018年1月. 髙木康志 :
脳動脈奇形の基礎研究と外科的治療,
脳血管障害セミナー, 2018年1月. 髙木康志 :
脳動静脈奇形に対する外科的治療の現状/脳卒中後遺症に対するHALによる機能再生,
Stroke Conference in Fukuoka, 2017, 2017年12月. 羽星辰哉, 多田恵曜, 藤原敏孝, 亘雄也, 中島公平, 髙木康志 :
前方脳梁離断術を施行した成人難治性てんかんの2例,
第43回徳島脳神経外科談話会, 2017年12月. 鹿草宏, 兼松康久, 山本雄貴, 高麗雅章, 山本伸昭, 里見淳一郎, 髙木康志 :
急性期血行再建術後に腎不全をきたした1例,
第43回徳島脳神経外科談話会, 2017年12月. 高麗雅章, 牟礼英生, 佐藤裕一, 兼松康久, 里見淳一郎, 髙木康志 :
蝶形頭頂静脈洞近傍にシャントを有し頭蓋内出血で発症した硬膜動静脈瘻の1例,
第43回徳島脳神経外科談話会, 2017年12月. 髙木康志 :
京都から徳島へ徳島大学脳神経外科の展望,
第43回徳島脳神経外科談話会, 2017年12月. 髙木康志 :
HALを用いた治療の現状と今後の展開,
北海道HAL研究会, 2017年11月. 髙木康志 :
京都大学におけるHALを用いた治療の現状と今後の展開,
HAL特別セミナー, 2017年2月. 植野美彦, 関陽介, 井戸慶治, 髙木康志, 阪上浩, 生島仁史, 藤猪英樹, 白山靖彦, 田中秀治, 川田昌武, 長宗秀明, 古屋 S. 玲, 上岡麻衣子 :
令和元年度徳島大学高等教育研究センターアドミッション部門報告書,
令和元年度徳島大学高等教育研究センターアドミッション部門報告書, 2020年3月.

特許: 研究者総覧に該当データはありませんでした。
作品: 研究者総覧に該当データはありませんでした。
補助金・競争的資金: 脳血管障害に影響を及ぼす特定歯周病菌の同定とその制御法の検討 (研究課題/領域番号: 23K08500 )
脳動静脈奇形における血管内皮のKRAS変異とPAD4活性化の関係 (研究課題/領域番号: 22K09259 )
脳動脈瘤破裂におけるinflammasome活性化とsirtuinの役割 (研究課題/領域番号: 20K09391 )
歯周病巣のexosomeによる脳動脈瘤破裂への影響 (研究課題/領域番号: 20K09326 )
血管狭窄因子RNF213の修飾因子特定とそれに基づく疾患モデルと新規治療法の確立 (研究課題/領域番号: 16H05437 )
小児もやもや病の多施設コホート研究：成人後のQOLの解明と関連要因の探索 (研究課題/領域番号: 26861147 )
もやもや病の分子病態の解明とその成果に基づく予防・創薬事業 (研究課題/領域番号: 25253047 )
多能性幹細胞（iPS細胞）を利用した脳梗塞に対する再生医療の開発 (研究課題/領域番号: 25293308 )
動脈硬化性巣における新規血管新生調節因子バソヒビンの発現様式と病的意義の解明 (研究課題/領域番号: 24592125 )
頭蓋内主幹動脈閉塞性疾患における分子メカニズムの解明 (研究課題/領域番号: 24390343 )
胚性幹細胞および骨髄間質細胞より誘導した神経幹細胞を利用した脳梗塞治療の開発 (研究課題/領域番号: 20390382 )
霊長類胚性幹細胞由来神経幹細胞を利用した脳梗塞に対する神経再生治療 (研究課題/領域番号: 18591588 )
虚血性神経細胞障害におけるMAPK情報伝達系の関わりについて (研究課題/領域番号: 17390398 )
霊長類ES細胞由来神経細胞を利用した脳梗塞の治療 (研究課題/領域番号: 15790766 )
実験的脳動脈瘤における遺伝子発現 (研究課題/領域番号: 15659335 )
虚血耐性を応用した脳梗塞治療の開発のための基礎研究 (研究課題/領域番号: 15390437 )
研究者番号（40312227）による検索

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研究者総覧で最新データを確認する

2024年11月22日更新

専門分野・研究分野: 研究者総覧に該当データはありませんでした。
所属学会・所属協会: 日本脳神経外科学会
日本脳卒中学会
日本脳卒中の外科学会
脳神経外科手術と機器学会
日本循環代謝学会
日本心血管脳卒中学会
第11回全国てんかんセンター協議会総会
第96回日本脳神経外科学会中国四国支部学術集会
委員歴・役員歴: 日本脳神経外科学会 (理事)
日本脳卒中学会 (理事)
日本脳卒中の外科学会 (理事)
脳神経外科手術と機器学会 (理事)
日本循環代謝学会 (理事)
日本心血管脳卒中学会 (学術評議員)
第96回日本脳神経外科学会中国四国支部学術集会 (会長)
受賞: 2024年1月, e-とくしま推進財団表彰 (e-とくしま推進財団)
2024年2月, 優秀発表賞 (日本定位・機能神経外科学会)
活動: 徳島県循環器病対策推進協議会 (委員)

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2024年11月17日更新

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Ｊグローバル

Jグローバル最終確認日: 2024/11/16 01:04
氏名（漢字）: 髙木康志
氏名（フリガナ）: JグローバルAPIで取得できませんでした。
氏名（英字）: Takagi Yasushi
所属機関: 京都大学

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researchmap最終確認日: 2024/11/17 01:22
氏名（漢字）: 髙木康志
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氏名（英字）: Takagi Yasushi
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登録日時: 2014/7/27 13:40
更新日時: 2021/10/26 15:35
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2024年11月16日更新

研究者番号: 40312227

所属（現在）: 2024/4/1 : 徳島大学, 大学院医歯薬学研究部(医学域), 教授

所属（過去の研究課題 情報に基づく）*注記: 2020/4/1 – 2023/4/1 : 徳島大学, 大学院医歯薬学研究部(医学域), 教授
2018/4/1 : 徳島大学, 大学院医歯薬学研究部(医学域), 教授
2017/4/1 : 徳島大学
2016/4/1 – 2017/4/1 : 京都大学, 医学研究科, 准教授
2013/4/1 – 2016/4/1 : 京都大学, 医学(系)研究科(研究院), 准教授
2015/4/1 : 京都大学, 大学院医学研究科, 准教授
2014/4/1 : 京都大学, 医学研究科, 准教授
2011/4/1 – 2012/4/1 : 京都大学, 医学研究科, 准教授
2010/4/1 : 京都大学, 医学研究科, 講師
2009/4/1 – 2010/4/1 : 京都大学, 医学研究科, 非常勤講師
2007/4/1 – 2008/4/1 : 京都大学, 医学研究科, 講師
2007/4/1 : 京都大学, 医学研究科, 助教
2003/4/1 – 2006/4/1 : 京都大学, 医学研究科, 助手

審査区分/研究分野

研究代表者

生物系 / 医歯薬学 / 外科系臨床医学 / 脳神経外科学
小区分56010:脳神経外科学関連

研究代表者以外

生物系 / 医歯薬学 / 外科系臨床医学 / 脳神経外科学
生物系 / 医歯薬学 / 社会医学 / 疫学・予防医学
小区分56010:脳神経外科学関連

キーワード

研究代表者

胚性幹細胞 / 脳虚血 / SDIA / 免疫組織 / 神経幹細胞 / ES細胞 / 脳梗塞 / 再生医療 / 霊長類ES細胞 / 脳梗塞モデル / 骨髄間質細胞 / 移植 / iPS細胞 / 移植治療 / 脳血管障害学 / 神経幹細胞移植 / 神経再生治療 / 霊長類 / ES cell / brain ischemia / regenerative therapy / primate / 脳動静脈奇形 / KRAS変異 / NETｓ形成 / PAD4 / 血管新生 / KRAS遺伝子 / CitH3

研究代表者以外

脳動脈瘤 / 遺伝子 / 遺伝子発現 / 脳神経外科学 / 脳卒中 / 脳血管障害 / 頭蓋内主幹動脈 / もやもや病 / 脳梗塞 / 動脈硬化 / 不安定プラーク / 頚動脈狭窄 / プラーク内出血 / 血管新生調節因子 / バソヒビン / 血管新生 / 分子イメージング / 分子遺伝疫学 / 予防医学 / 社会医学 / 衛生学 / 医歯薬学 / MAPK / 脳虚血 / 虚血耐性 / STAT / MARK / Cerebral ischemia / Ischemic tolerance / 神経細胞死 / 脳神経疾患 / cerebral ischemia / ischemic tolerance / RNF213 / 脳血管障害学 / 生活の質 / 社会的アウトカム / 認知機能 / moyamoya disease / quality of life / SAH / intracranial aneurysms / periodontal disease / periodontal bacteria / exosome / 歯周病 / sirtuin / ERα / 破裂性脳血管病 / 脳動脈瘤破裂 / 歯周病菌 / Inflammasome / NLRP3 / ERa / NLRP3　inflammasome / Sirtuin / くも膜下出血 / NLRP3 inflammasome / 重症歯周病 / クモ膜下出血 / NETosis

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髙木 康志

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髙木康志