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高石喜久

徳島大学

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リサーチマップ・
Jグローバル
KAKEN
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2024年5月9日更新

職名: 名誉教授 (2020.4)
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学歴: 1969/3: 徳島大学薬学部製薬化学科卒業
1973/12: 京都大学大学院薬学研究科博士課程退学
学位: 薬学博士 (京都大学) (1980年9月)
職歴・経歴: 1974/1: 徳島大学薬学部.助手
1983/8: 徳島大学薬学部.助教授
1992/9: 徳島大学薬学部.教授

専門分野・研究分野: 生薬学 (Pharmacognosy)
天然物化学 (Natural Products Chemistry)

研究者総覧で最新データを確認する

2024年5月9日更新

専門分野・研究分野: 生薬学 (Pharmacognosy)
天然物化学 (Natural Products Chemistry)
担当経験のある授業科目: 研究者総覧に該当データはありませんでした。
指導経験: 研究者総覧に該当データはありませんでした。

研究者総覧で最新データを確認する

2024年5月9日更新

専門分野・研究分野: 生薬学 (Pharmacognosy)
天然物化学 (Natural Products Chemistry)

研究テーマ: 天然薬物に関する研究, ヘルスケアに有用な天然物に関する研究 (天然薬物, 生薬, ヘルスケア)

著書

森田秀芳, 桑折範彦, 高石喜久, 廣渡修一, 宮本賢一 :
授業改善のための授業研究会運営ハンドブック, --- 徳島大学FD推進ハンドブック第4巻 ---,
大学開放実践センター, 徳島, 2002年12月.

論文

Naonobu Tanaka, Yuki Yoshino, Fusako Nakano, Shin-ichiro Kurimoto, Kazuyoshi Kawazoe, Daisuke Tsuji, Kouji Itou, Shun-Lin Li, Han-Dong Sun, Yoshihisa Takaishi and Yoshiki Kashiwada :
Lanicepines A and B, sesquiterpenes with amino acid-derived substituents from the flowering aerial parts of Saussurea laniceps,
Journal of Natural Products, Vol.85, No.4, 1180-1185, 2022.

(出版サイトへのリンク): ● Publication site (DOI): 10.1021/acs.jnatprod.1c01069
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1021/acs.jnatprod.1c01069

(DOI: 10.1021/acs.jnatprod.1c01069) Hiroyuki Mizuguchi, Y Nariai, S Kato, T Nakano, T Kanayama, Yoshiki Kashiwada, Hisao Nemoto, Kazuyoshi Kawazoe, Yoshihisa Takaishi, Yoshiaki Kitamura, Noriaki Takeda and Hiroyuki Fukui :
Maackiain is a novel antiallergic compound that suppresses transcriptional upregulation of the histamine H1 receptor and interleukin-4 genes.,
Pharmacology Research & Perspectives, Vol.3, No.5, e00166, 2015.

(要約): Kujin contains antiallergic compounds that inhibit upregulation of histamine H1 receptor (H1R) and interleukin (IL)-4 gene expression. However, the underlying mechanism remains unknown. We sought to identify a Kujin-derived antiallergic compound and investigate its mechanism of action. The H1R and IL-4 mRNA levels were determined by real-time quantitative RT-PCR. To investigate the effects of maackiain in vivo, toluene-2,4-diisocyanate (TDI)-sensitized rats were used as a nasal hypersensitivity animal model. We identified (-)-maackiain as the responsible component. Synthetic maackiain showed stereoselectivity for the suppression of IL-4 gene expression but not for H1R gene expression, suggesting distinct target proteins for transcriptional signaling. (-)-Maackiain inhibited of PKCδ translocation to the Golgi and phosphorylation of Tyr(311) on PKCδ, which led to the suppression of H1R gene transcription. However, (-)-maackiain did not show any antioxidant activity or inhibition of PKCδ enzymatic activity per se. Pretreatment with maackiain alleviated nasal symptoms and suppressed TDI-induced upregulations of H1R and IL-4 gene expressions in TDI-sensitized rats. These data suggest that (-)-maackiain is a novel antiallergic compound that alleviates nasal symptoms in TDI-sensitized allergy model rats through the inhibition of H1R and IL-4 gene expression. The molecular mechanism underlying its suppressive effect for H1R gene expression is mediated by the inhibition of PKCδ activation.
(徳島大学機関リポジトリ): ● Metadata: 115685
(出版サイトへのリンク): ● Publication site (DOI): 10.1002/prp2.166
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26516579; ● Search Scopus @ Elsevier (PMID): 26516579; ● Search Scopus @ Elsevier (DOI): 10.1002/prp2.166

(徳島大学機関リポジトリ: 115685, DOI: 10.1002/prp2.166, PubMed: 26516579) Shin-Ichiro Kurimoto, Jian-Xin Pu, Han-Dong Sun, Yoshihisa Takaishi and Yoshiki Kashiwada :
Coleifolides A and B, Two New Sesterterpenoids from the Aerial Parts of Scutellaria coleifolia H.Lév.,
Chemistry & Biodiversity, Vol.12, No.8, 1200-1207, 2015.

(要約): Coleifolides A and B (1 and 2), two new sesterterpenoids with a -methyl-,-unsaturated--lactone moiety, were isolated from the aerial parts of Scutellaria coleifolia H.Lév. (Lamiaceae), together with three known compounds. Their structures were elucidated by NMR and MS examinations. Coleifolides A and B were concluded to be partially racemic compounds by the HPLC analysis using a chiral column or introduction of chiral derivatizing agents. The absolute configuration of the major isomer was determined by analyses of the CD spectrum as well as NMR data of (R)- and (S)-2-NMA derivatives. Coleifolides A and B are structurally similar to manoalide derivatives, previously isolated from marine sponges, and appear to be the first examples of this type of compounds being isolated from higher plants.
(出版サイトへのリンク): ● Publication site (DOI): 10.1002/cbdv.201400248
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26265571; ● Summary page in Scopus @ Elsevier: 2-s2.0-84934886601

(DOI: 10.1002/cbdv.201400248, PubMed: 26265571, Elsevier: Scopus) Shin-ichiro Kurimoto, Jian-Xin Pu, Han-Dong Sun, Yoshihisa Takaishi and Yoshiki Kashiwada :
Acylated neo-clerodanes and 19-nor-neo-clerodanes from the aerial parts of Scutellaria coleifolia (Lamiaceae).,
Phytochemistry, Vol.116, 298-304, 2015.

(要約): Scutefolides A1 and A2, two acylated neo-clerodanes with a 19,18--lactone, scutefolides B1, B2 and C, three 19-nor-neo-clerodanes, together with scutefolides D, E1, E2 and F, four neo-clerodanes, were isolated from the EtOAc-soluble fraction of the aerial parts of Scutellaria coleifolia. Their structures were established on the basis of spectroscopic analysis. The absolute configurations of four of these compounds were elucidated by the CD exciton chirality method. Cytotoxic activities of scutefolides D-F against four cancer cell lines (KB, A549, HeLa, and MCF7) were also evaluated, but they were inactive.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.phytochem.2015.05.012
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26026223; ● Search Scopus @ Elsevier (PMID): 26026223; ● Search Scopus @ Elsevier (DOI): 10.1016/j.phytochem.2015.05.012

(DOI: 10.1016/j.phytochem.2015.05.012, PubMed: 26026223) Tsuyoshi Goto, Noritaka Hirazawa, Yoshihisa Takaishi and Yoshiki Kashiwada :
Antiparasitic effect of matrine and oxymatrine (quinolizidine alkaloids) on the ciliate Cryptocaryon irritans in the red sea bream Pagrus major.,
Aquaculture, Vol.437, 339-343, 2015.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.aquaculture.2014.12.026
(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-84920120223

(DOI: 10.1016/j.aquaculture.2014.12.026, Elsevier: Scopus) Goto Tsuyoshi, Hirazawa Noritaka, Yoshihisa Takaishi and Yoshiki Kashiwada :
Antiparasitic effects of Sophora flavescens root extracts on the ciliate, Cryptocaryon irritans,
Aquaculture, Vol.435, No.C, 173-177, 2015.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.aquaculture.2014.09.007
(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-84908539753

(DOI: 10.1016/j.aquaculture.2014.09.007, Elsevier: Scopus) Chika Hashida, Naonobu Tanaka, Kazuyoshi Kawazoe, Kotarou Murakami, Han-Dong Sun, Yoshihisa Takaishi and Yoshiki Kashiwada :
Hypelodins A and B, polyprenylated benzophenones from Hypericum elodeoides.,
Journal of Natural Medicines, Vol.68, No.4, 737-742, 2014.

(要約): Two new polyprenylated benzophenones, hypelodins A (1) and B (2), were isolated from the aerial parts of the Chinese medicinal plant Hyperium elodeoides (Choisy). Their structures were elucidated on the basis of spectroscopic evidence. Hypelodin A (1) is a polyprenylated benzophenone having a tetrahydropyrane ring with three prenyl groups and one 4-methyl-1,3-pentadiene moiety, while hypelodin B (2) has a cage-like structure with a 6/6/5/7/6/5 hexacyclic ring system.
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s11418-014-0853-9
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25081326; ● Search Scopus @ Elsevier (PMID): 25081326; ● Search Scopus @ Elsevier (DOI): 10.1007/s11418-014-0853-9

(DOI: 10.1007/s11418-014-0853-9, PubMed: 25081326) Masashi Akaike, Ken-ichi Aihara, Hiroaki Yanagawa, Takashi Iwase, Sumiko Yoshida, Sato Chiho, Saijo Tomoka, Hiroaki Mikasa, Kashiwada Yoshizaki, Yoshihisa Takaishi, Koichiro Tsuchiya, Toshiaki Tamaki, Toshio Matsumoto and Masataka Sata :
Efficacy and safety of Citrus sudachi peel in obese adults:A randomized, double-blind, pilot study,
Functional Foods in Health and Disease, Vol.4, No.6, 276-284, 2014.

(出版サイトへのリンク): ● Publication site (DOI): 10.31989/ffhd.v4i7.5
(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-85054855286

(DOI: 10.31989/ffhd.v4i7.5, Elsevier: Scopus) Hisako Sasaki, Hirofumi Shibata, Kiyoshi Imabayashi, Yoshihisa Takaishi and Yoshiki Kashiwada :
Prenylated Flavonoids from the Stems and Leaves of Desmodium caudatum and Evaluation of Their Inhibitory Activity against the Film-Forming Growth of Zygosaccharomyces rouxii F51.,
Journal of Agricultural and Food Chemistry, Vol.62, No.27, 6345-6353, 2014.

(要約): In order to provide scientific evidence for the relationship between the traditional usage, stems and leaves of Desmodium caudatum being used for protecting miso from spoilage, and its Japanese name (miso-naoshi), phytochemical study on the stems and leaves of this plant was carried out. Seven new prenylated flavonoids (1-3, 15-18), together with 19 known compounds (4-14, 19-26), were isolated, and the structures of new compounds were elucidated by extensive spectroscopic analyses. The minimum inhibitory concentrations (MICs) of 28 flavonoids, including 17 compounds (1, 2, 4, 5, 7-14, 20-22, 24, 25) isolated in this study and 11 flavonoids (27-37) previously isolated from the roots of this plant, against the film-forming yeast of Zygosaccharomyces rouxii F51 were determined. Fifteen compounds (2, 4, 5, 11, 12, 14, 21, 22, 25, 27, 28, 32-35) inhibited the film-forming growth of Z. rouxii F51 (MIC values, 7.8-62.5 g/mL), among which 2'',2''-dimethylpyran-(5'',6'':7,8)-5,2'-dihydroxy-4'-methoxy-(2R,3R)-dihydroflavonol (11) demonstrated potent inhibitory activity with an MIC value of 7.8 g/mL.
(出版サイトへのリンク): ● Publication site (DOI): 10.1021/jf5020439
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24956381; ● Summary page in Scopus @ Elsevier: 2-s2.0-84903973802

(DOI: 10.1021/jf5020439, PubMed: 24956381, Elsevier: Scopus) Shin-ichiro Kurimoto, Yoshihisa Takaishi, Fakhruddin Ali Ahmed and Yoshiki Kashiwada :
Triterpenoids from the fruits of Azadirachta indica (Meliaceae).,
Fitoterapia, Vol.92, 200-205, 2014.

(要約): Four new triterpenoids, indicalilacols A-D (1-4), were isolated from the MeOH extract of the fruits of Azadirachta indica, including a new 19(109)abeo-tirucallane derivative, two new tirucallane-type triterpenoids, and a new euphane-type triterpenoid, along with three known tirucallane-type triterpenoids. Their structures were elucidated on the basis of spectroscopic analyses. The absolute configuration of 2 was elucidated by the chemical conversion of 2 into 21-oxo-melianodiol 24,25-acetonide. Compounds 2, 6-8 exhibited moderate cytotoxicity against three human cancer cell lines, including multidrug-resistant (MDR) cancer cells (KB-C2). Although compound 5 was not cytotoxic against any of the tested cancer cell lines, 5 showed cytotoxicity against KB-C2 cells in the presence of 2.5 M colchicine, suggesting that 5 might have an MDR-reversal effect.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.fitote.2013.11.004
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24239747; ● Summary page in Scopus @ Elsevier: 2-s2.0-84890056124

(DOI: 10.1016/j.fitote.2013.11.004, PubMed: 24239747, Elsevier: Scopus) Yoshiki Kashiwada, Yuka Omichi, Shin-ichiro Kurimoto, Hirofumi Shibata, Yoshiyuki Miyake, Tsukasa Kirimoto and Yoshihisa Takaishi :
Conjugates of a secoiridoid glucoside with a phenolic glucoside from the flower buds of Lonicera japonica Thunb.,
Phytochemistry, Vol.96, 423-429, 2013.

(要約): Secoiridoid glucosides, including two conjugates with a phenolic and two conjugates with a nicotinic acid derivative (3 and 4), together with seven known secoiridoid derivatives, were isolated from flower buds of Lonicera japonica. The structures were elucidated by spectroscopic analyses. Anti-influenza activities of six isolated compounds were also evaluated by plaque assay and neuraminidase inhibitory assay.
(キーワード): Antiviral Agents / Flowers / Influenza A virus / Iridoid Glucosides / Lonicera / 分子構造 (molecular structure) / Neuraminidase / Nicotinic Acids / Phenols
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.phytochem.2013.09.021
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24120297; ● Search Scopus @ Elsevier (PMID): 24120297; ● Search Scopus @ Elsevier (DOI): 10.1016/j.phytochem.2013.09.021

(DOI: 10.1016/j.phytochem.2013.09.021, PubMed: 24120297) Yoshihiro Suyama, Shin-ichiro Kurimoto, Kazuyoshi Kawazoe, Kotarou Murakami, Han-Dong Sun, Shun-Lin Li, Yoshihisa Takaishi and Yoshiki Kashiwada :
Rigenolide A, a new secoiridoid glucoside with a cyclobutane skeleton, and three new acylated secoiridoid glucosides from Gentiana rigescens Franch.,
Fitoterapia, Vol.91, 166-172, 2013.

(要約): Rigenolide A (1), a new secoiridoid glucoside with a cyclobutane skeleton and three new acylated secoiridoid glucosides, 2'-(2,3-dihydroxybenzoyl)-gentiopicroside (2), 2'-(2,3-dihydroxybenzoyl)-swertiamarin (3), 3'-(2,3-dihydroxybenzoyl)-sweroside (4), along with two noriridoids (7 and 8) and two known secoiridoid glucosides (5 and 6), were isolated from Gentiana rigescens Franch. The structures of new compounds were elucidated by extensive spectroscopic analyses. The isolated compounds were evaluated for DPPH free-radical scavenging activity.
(キーワード): Acylation / Biphenyl Compounds / Gentiana / Iridoid Glucosides / 分子構造 (molecular structure) / Picrates / Plant Extracts / Pyrones
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.fitote.2013.08.006
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23994629; ● Search Scopus @ Elsevier (PMID): 23994629; ● Search Scopus @ Elsevier (DOI): 10.1016/j.fitote.2013.08.006

(DOI: 10.1016/j.fitote.2013.08.006, PubMed: 23994629) Takashi Ichiyanagi, Yoshiki Kashiwada, Yasuo Shida, Michiko Sekiya, Yoshihiko Hatano, Yoshihisa Takaishi and Yasumasa Ikeshiro :
Structural elucidation and biological fate of two glucuronyl metabolites of pelargonidin 3-O--D-glucopyranoside in rats.,
Journal of Agricultural and Food Chemistry, Vol.61, No.3, 569-578, 2013.

(要約): A high proportion of pelargonidin 3-O--D-glucopyranoside (Pg3G) is metabolized to glucuronides and excreted in mammal urine after ingestion of strawberry fruit, suggesting that these metabolites play important functional roles in vivo. The aim of the present study was to elucidate the structures and determine the biological fate of the two dominant metabolites of Pg3G in rats to enable an accurate discussion of the biological properties of anthocyanins. Authentic Pg3G was orally administered to rats. One pelargonidin monoglucuronide and three Pg3G-monoglucuronides (glucuronides of the glucoside) were identified together with intact Pg3G in both blood plasma and urine samples. The structures of the two dominant metabolites were elucidated as pelargonidin 3-O--D-glucuronide (Pg3GlcA) and pelargonidin 3-O--D-glucuronyl-(12)--D-glucoside by means of (1)H and (13)C nuclear magnetic resonance spectroscopy and heteronuclear multiple-bond connective spectroscopy. The bioavailability of Pg3G in its intact form was 0.31% of the orally administered dose, and 0.65% was absorbed in the Pg3GlcA form.
(出版サイトへのリンク): ● Publication site (DOI): 10.1021/jf3032793
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23256460; ● Search Scopus @ Elsevier (PMID): 23256460; ● Search Scopus @ Elsevier (DOI): 10.1021/jf3032793

(DOI: 10.1021/jf3032793, PubMed: 23256460) Kurimoto Shin-ichiro, Suzuki Kyoko, Okasaka Mamoru, Yoshiki Kashiwada, Kodzhimatov K. Olimjon and Yoshihisa Takaishi :
New sesquiterpene lactone glucosides from the roots of Ferula varia.,
Phytochemistry Letters, Vol.5, No.4, 729-733, 2012.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.phytol.2012.08.001
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1016/j.phytol.2012.08.001

(DOI: 10.1016/j.phytol.2012.08.001) Hisako Sasaki, Yoshiki Kashiwada, Hirofumi Shibata and Yoshihisa Takaishi :
Prenylated flavonoids from the roots of Desmodium caudatum and evaluation of their antifungal activity.,
Planta Medica, Vol.78, No.17, 1851-1856, 2012.

(要約): Two new prenylated flavonoids (1, 4) and two new prenylated C-methyl-flavonoids (6, 7), together with four known flavonoids (2, 3, 5, 8), were isolated from the roots of Desmodium caudatum. The structures of the new compounds were elucidated by extensive spectroscopic analyses including 1D-, 2D-NMR and MS. The antifungal activities of five compounds (1, 2, 4, 6, 8) as well as nine flavonoids (9-17) previously isolated from this plant against Aspergillus niger, Penicillium sp., Rhizopus sp., and Trichophyton sp. were evaluated. Compound 6 showed potent antifungal activity against Trichophyton sp. with a minimum inhibitory concentration (MIC) value of 1.95 µg/mL.
(キーワード): Antifungal Agents / Aspergillus niger / Fabaceae / フラボノイド (flavonoids) / Microbial Sensitivity Tests / 分子構造 (molecular structure) / Penicillium / Plant Roots / Rhizopus / Trichophyton
(出版サイトへのリンク): ● Publication site (DOI): 10.1055/s-0032-1315391
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23059627; ● Search Scopus @ Elsevier (PMID): 23059627; ● Search Scopus @ Elsevier (DOI): 10.1055/s-0032-1315391

(DOI: 10.1055/s-0032-1315391, PubMed: 23059627) Hisako Sasaki, Yoshiki Kashiwada, Hirofumi Shibata and Yoshihisa Takaishi :
Prenylated flavonoids from Desmodium caudatum and evaluation of their anti-MRSA activity.,
Phytochemistry, Vol.82, 136-142, 2012.

(要約): Seven prenylated flavonoids and a prenylated chromanochroman derivative, together with eight known flavonoids, were isolated from roots of Desmodium caudatum. The 15 structures were elucidated by extensive spectroscopic analyses. The antibacterial activity of many of other compounds was evaluated against methicillin-resistant Staphylococcus aureus (MRSA: COL and 5) by a disc diffusion method, and the minimum inhibitory concentrations (MICs) to MRSA were determined.
(キーワード): Anti-Bacterial Agents / Fabaceae / フラボノイド (flavonoids) / Methicillin-Resistant Staphylococcus aureus / Microbial Sensitivity Tests / Prenylation
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.phytochem.2012.06.007
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22800912; ● Search Scopus @ Elsevier (PMID): 22800912; ● Search Scopus @ Elsevier (DOI): 10.1016/j.phytochem.2012.06.007

(DOI: 10.1016/j.phytochem.2012.06.007, PubMed: 22800912) Tamotsu Tanaka, Ayaka Kassai, Mayumi Ohmoto, Katsuya Morito, Yoshiki Kashiwada, Yoshihisa Takaishi, Mai Urikura, Jun-ichi Morishige, Kiyoshi Satouchi and Akira Tokumura :
Quantification of phosphatidic acid in foodstuffs using TLC-imaging technique,
Journal of Agricultural and Food Chemistry, Vol.60, No.16, 4156-4161, 2012.

(要約): Apical application of lysophosphatidic acid (LPA), a growth-factor-like phospholipid, was shown to prevent or restore gastrointestinal (GI) disorders, such as diarrhea and stomach ulcer, in experimental animals. Because LPA is formed from phosphatidic acid (PA) by the activity of digestive phospholipase A(2), PA is a potential component for dietary treatment of such GI disorders. Here, we quantified PA contained in 38 foodstuffs and 3 herbs by a thin-layer-chromatography-imaging technique. Vegetables belonging to Brassicaceae, such as cabbage leaves (700 nmol/g of wet weight) and Japanese radish leaves (570 nmol/g), contained higher amounts of PA than other foodstuffs. Amounts of PA in fruits, cereals, and starchy root vegetables were below 300 nmol/g. Animal foodstuffs contained low amounts of PA (<60 nmol/g). Interestingly, leaves of Mallotus japonicas, a Japanese edible herb used for treatment of stomach ulcer, had the highest PA (1410 nmol/g) among those examined. The data shown here will be useful for the development of dietary treatment for a damaged GI tract.
(キーワード): Chromatography, Thin Layer / Food Analysis / Phosphatidic Acids
(出版サイトへのリンク): ● Publication site (DOI): 10.1021/jf300147y
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22475031; ● Summary page in Scopus @ Elsevier: 2-s2.0-84860316722

(DOI: 10.1021/jf300147y, PubMed: 22475031, Elsevier: Scopus) Yoshiki Kashiwada, Fakhruddin Ali Ahmed, Shin-ichiro Kurimoto, Sang-Yong Kim, Hirofumi Shibata, Toshihiro Fujioka and Yoshihisa Takaishi :
New α-glucosides of caffeoyl quinic acid from the leaves of Moringa oleifera Lam.,
Journal of Natural Medicines, Vol.66, No.1, 217-221, 2012.

(要約): Two new caffeoyl quinic acid α-glucosides, together with three known caffeoyl quinic acids and five known flavonoid glucosides, were isolated from the leaves of Moringa oleifera Lam. The structures of the new compounds were elucidated as 4-O-(4'-O-α-D-glucopyranosyl)-caffeoyl quinic acid (1) and 4-O-(3'-O-α-D-glucopyranosyl)-caffeoyl quinic acid (2) by spectroscopic analyses.
(キーワード): Animals / Antiviral Agents / Cell Line / Dogs / Enzyme Inhibitors / Free Radical Scavengers / Glucosides / Influenza A Virus, H1N1 Subtype / 核磁気共鳴分光法 (nuclear magnetic resonance spectroscopy) / 質量分析法 (mass spectrometry) / 分子構造 (molecular structure) / Moringa oleifera / Neuraminidase / Plant Leaves / Quinic Acid / 構造活性相関 (structureactivity relationship)
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s11418-011-0563-5
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21748486; ● Search Scopus @ Elsevier (PMID): 21748486; ● Search Scopus @ Elsevier (DOI): 10.1007/s11418-011-0563-5

(DOI: 10.1007/s11418-011-0563-5, PubMed: 21748486) Shin-ichiro Kurimoto, Yoshiki Kashiwada, Kuo-Hsiung Lee and Yoshihisa Takaishi :
Triterpenes and a triterpene glucoside from Dysoxylum cumingianum and their cytotoxicity.,
Phytochemistry, Vol.72, No.17, 2205-2211, 2011.

(要約): Six triterpenes and a triterpene glucoside were isolated from the MeOH extract of the leaves of Dysoxylum cumingianum together with three known triterpenes. Their structures were elucidated by extensive spectroscopic analyses. In cytotoxicity assays against three human cancer cell lines, including a multi-drug resistant cancer cell line (KB-C2), compounds 1, 2 and 5 demonstrated significantly enhanced cytotoxicity against KB-C2 cells in the presence of 2.5 μM colchicine, as compared with those in the absence of colchicine. This result suggested that these triterpenes might show some MDR-reversing effects.
(キーワード): Antineoplastic Agents, Phytogenic / Cell Line, Tumor / Colchicine / Drug Resistance, Multiple / Glucosides / Humans / Meliaceae / Molecular Structure / Neoplasms / Phytotherapy / Plant Extracts / Plant Leaves / Triterpenes / Tubulin Modulators
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.phytochem.2011.08.002
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21899865; ● Search Scopus @ Elsevier (PMID): 21899865; ● Search Scopus @ Elsevier (DOI): 10.1016/j.phytochem.2011.08.002

(DOI: 10.1016/j.phytochem.2011.08.002, PubMed: 21899865) Kim Sang-Yong, Yoshiki Kashiwada, Kazuyoshi Kawazoe, Kotarou Murakami, Sun Han-Dong, Li Shun-Lin and Yoshihisa Takaishi :
Spicachlorantins G-J, New Lindenane Sesquiterpenoid Dimers from the Roots of Chloranthus spicatus.,
Chemical & Pharmaceutical Bulletin, Vol.59, No.10, 1281-1284, 2011.

(要約): Four new lindenane sesquiterpenoid dimers, spicachlorantins G-J (1-4), were isolated from the roots of Chloranthus spicatus together with seven known compounds, including chloramultilide A, shizukaol B, shizukaol D, shizukaol F, shizukaol P, chlorahololide D, and cycloshizukaol A. The planar structures of the new compounds were established by 1D-, 2D-NMR, and MS analyses. The absolute configurations of these compounds were determined by analyzing rotating Overhauser enhancement and exchange spectroscopy (ROESY) and circular dichroism (CD) spectra.
(キーワード): Circular Dichroism / Dimerization / Ferns / Molecular Conformation / Molecular Structure / Plant Extracts / Plant Roots / Sesquiterpenes
(出版サイトへのリンク): ● Publication site (DOI): 10.1248/cpb.59.1281
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21963639; ● Search Scopus @ Elsevier (PMID): 21963639; ● Search Scopus @ Elsevier (DOI): 10.1248/cpb.59.1281

(DOI: 10.1248/cpb.59.1281, PubMed: 21963639) Shin-ichiro Kurimoto, Yoshiki Kashiwada, Susan L. Morris-Natschke, Kuo-Hsiung Lee and Yoshihisa Takaishi :
Dyscusins AC, Three New Steroids From the Leaves of Dysoxylum cumingianum.,
Chemical & Pharmaceutical Bulletin, Vol.59, No.10, 1303-1306, 2011.

(要約): Three new steroids dyscusins A-C (1-3), including a stigmastane-type sterol and two pregnanes, together with two known steroids were isolated from the leaves of Dysoxylum cumingianum (Meliaceae). Their structures were elucidated on the basis of extensive spectroscopic analyses. In a cytotoxicity assay, compound 1 showed ten-fold enhanced cytotoxicity against multi-drug resistant cancer cells (KB-C2) in the presence of 2.5 µM colchicine as compared with the absence of colchicine. This notable finding indicated that 1 possessed a multi-drug resistant reversal effect.
(キーワード): Antineoplastic Agents, Phytogenic / Cell Line, Tumor / Colchicine / Drug Screening Assays, Antitumor / Humans / Meliaceae / Molecular Structure / Phytotherapy / Plant Leaves / Pregnanes / Steroids / Sterols / Tubulin Modulators
(出版サイトへのリンク): ● Publication site (DOI): 10.1248/cpb.59.1303
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21963644; ● Search Scopus @ Elsevier (PMID): 21963644; ● Search Scopus @ Elsevier (DOI): 10.1248/cpb.59.1303

(DOI: 10.1248/cpb.59.1303, PubMed: 21963644) Ahmed Ali Fakhruddin, Kim Sang-Yong, Kurimoto Shin-ichiro, Sasaki Hisako, Hirofumi Shibata, Yoshiki Kashiwada and Yoshihisa Takaishi :
Biflavonoids from Flowers of Butea monosperma (Lam.) Taub.,
Heterocycles, Vol.83, No.9, 2079-2089, 2011.

(キーワード): Butea monosperma / Fabaceae / Biflavonoid / Neuraminidase / DPPH
(出版サイトへのリンク): ● Publication site (DOI): 10.3987/COM-11-12275
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1520291855472043392; ● Search Scopus @ Elsevier (DOI): 10.3987/COM-11-12275

(DOI: 10.3987/COM-11-12275, CiNii: 1520291855472043392) Yoshiki Kashiwada, Nishimura Kazuya, Kurimoto Shin-ichiro and Yoshihisa Takaishi :
New 29-nor-cycloartanes with a 3,4-seco- and a novel 2,3-seco-structure from the leaves of Sinocalycanthus chinensis.,
Bioorganic & Medicinal Chemistry, Vol.19, No.9, 2790-2796, 2011.

(要約): Eight new triterpenoids, including sinocalycanchinensins A-E (1-5) with a 3,4-seco-29-nor-cycloartane skeleton, sinocalycanchinensin F (6) possessing a novel 2,3-seco-29-nor-cycloartane skeleton, and 29-nor-cycloartanes, sinocalycanchinensins G and H (7 and 8), have been isolated from the leaves of Sinocalycanthus chinensis. Their structures were elucidated on the basis of spectroscopic examinations. The cytotoxicities of the isolated new triterpenes against a panel of human cancer cell lines, including multi-drug resistant (MDR) cancer cell lines, were also evaluated. Compound 5 demonstrated enhanced cytotoxicity against MDR KB cells in the presence of colchicine, although all the compounds showed moderate or no cytotoxicities.
(キーワード): Calycanthaceae / Cell Line, Tumor / Drug Screening Assays, Antitumor / Humans / Magnetic Resonance Spectroscopy / Molecular Conformation / Plant Leaves / Triterpenes
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.bmc.2011.03.055
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21493075; ● Search Scopus @ Elsevier (PMID): 21493075; ● Search Scopus @ Elsevier (DOI): 10.1016/j.bmc.2011.03.055

(DOI: 10.1016/j.bmc.2011.03.055, PubMed: 21493075) Xiong Juan, Taniguchi Masatoshi, Yoshiki Kashiwada, Yamagishi Takashi and Yoshihisa Takaishi :
Seven new dammarane triterpenes from the floral spikes of Betula platyphylla var. japonica.,
Journal of Natural Medicines, Vol.65, No.1, 217-223, 2011.

(要約): Seven new dammarane-type triterpenoids, including two 20(S)-hydroxy-25-methoxy-dammar-23-enes (1 and 2), two 20(S),24(R)-epoxydammaranes (3 and 4), a cabralealactone (5), and two 20(S),25-epoxydammaranes (6 and 7), together with seven known triterpenes (8-14), were isolated from the floral spikes of Betula platyphylla var. japonica. The structures for all compounds were elucidated by the analyses of extensive spectroscopic data, as well as chemical examinations.
(キーワード): Betula / Flowering Tops / Magnetic Resonance Spectroscopy / Molecular Structure / Triterpenes
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s11418-010-0462-1
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20814752; ● Search Scopus @ Elsevier (PMID): 20814752; ● Search Scopus @ Elsevier (DOI): 10.1007/s11418-010-0462-1

(DOI: 10.1007/s11418-010-0462-1, PubMed: 20814752) Kurimoto Shin-ichiro, Okasaka Mamoru, Yoshiki Kashiwada, K Olimjon Kodzhimatov and Yoshihisa Takaishi :
Four new glucosides from the aerial parts of Mediasia macrophylla,
Journal of Natural Medicines, Vol.65, No.1, 180-185, 2011.

(要約): As part of our chemical studies on the medical plants in Uzbekistan aimed at searching for new drug leads, we have examined the aerial parts of Mediasia macrophylla. This has resulted in the isolation of four new glucosides, together with 30 known compounds. The structures of new compounds were elucidated as (1'S)-(4-hydroxyphenyl) ethane-1',2'-diol 2'-O-β-glucopyranoside (1), 3-(4'-methoxyphenyl)-propanol 1-O-β-glucopyranoside (2), 2-methoxy-3-hydroxy-5-(E)-propenyl-phenol 1-O-β-glucopyranoside (3), 1-O-angeloyl-β-glucopyranose (4), on the basis of spectral analysis.
(キーワード): Apiaceae / Glucosides / Magnetic Resonance Spectroscopy / Molecular Structure / Plant Components, Aerial / Uzbekistan
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s11418-010-0444-3
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20640523; ● Search Scopus @ Elsevier (PMID): 20640523; ● Search Scopus @ Elsevier (DOI): 10.1007/s11418-010-0444-3

(DOI: 10.1007/s11418-010-0444-3, PubMed: 20640523) Wen Zhang, Zhi Yao, Wen Yan Zhang, Xiang Xing Zhang, Yoshihisa Takaishi and Quan Hong Duan :
Immunosuppressive sesquiterpenes from Buddleja daviddi,
Planta Medica, Vol.76, No.16, 1882-1887, 2010.

(要約): Six new sesquiterpenes, 2,6(12),10-humulatrien-7β-ol-1-one (1), 2 α-acetoxy-5α-methoxy-enantio-caryophylla-8(15)-en-3-one (2), 2α-acetoxy-5α-hydroxy-enantio-caryophylla-8(15)-en-3-one (3), 2α-acetoxy-4β,5α-hydroxy-enantio-caryophylla-8(15)-en-3-one ( 4), 2α-acetoxy-4β,5β-hydroxy-enantio-caryophylla-8(15)-en-3-one (5), 2β-acetoxy-4-caryophyllen-8β-ol-3-one (6), and nineteen known compounds were isolated from the ethanol extract of Buddleja daviddi. The structures were elucidated by spectroscopic methods. Compounds 8-11, 14, 16, 17, and 20 showed significant immunosuppressive activities, and 8-11 and 14 were cytotoxic on HeLa and L929 cell lines.
(キーワード): Antineoplastic Agents, Phytogenic / Buddleja / Cell Line, Tumor / HeLa Cells / Humans / Immunosuppressive Agents / Molecular Structure / Neoplasms / Phytotherapy / Plant Extracts / Rhizome / Sesquiterpenes
(出版サイトへのリンク): ● Publication site (DOI): 10.1055/s-0030-1249974
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20506074; ● Search Scopus @ Elsevier (PMID): 20506074; ● Search Scopus @ Elsevier (DOI): 10.1055/s-0030-1249974

(DOI: 10.1055/s-0030-1249974, PubMed: 20506074) Jie Teng, Rong Zhang, Yan-Wen Zhang, Hong-Quan Duan and Yoshihisa Takaishi :
A new labdanic norditerpene from Pinus sylvestris,
Natural Product Research, Vol.24, No.17, 1587-1591, 2010.

(要約): A new labdanic norditerpene and six known labdanic diterpenes were isolated from the petroleum ether extract of the needles of Pinus sylvestris. By spectroscopic methods, the isolated compounds were determined as 15-norpinifolic acid (1), pinifolic acid (2), 4-eplimbricataloic acid (3), monomethyl pinifolate (4), 18α-acetoxylabd-8(17)-en-15-oic acid (5), 2-pentenoic acid (6) and 3β-hydroxy-8(17),E-13-labdadien-15-oic acid (7), respectively. Compound 1 showed significant anti-tumour activity.
(キーワード): Chromatography, High Pressure Liquid / Diterpenes / Drug Screening Assays, Antitumor / HeLa Cells / Humans / Magnetic Resonance Spectroscopy / Pinus / Spectrometry, Mass, Electrospray Ionization / Spectrophotometry, Ultraviolet / Spectroscopy, Fourier Transform Infrared
(出版サイトへのリンク): ● Publication site (DOI): 10.1080/14786410802696684
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20954085; ● Search Scopus @ Elsevier (PMID): 20954085; ● Search Scopus @ Elsevier (DOI): 10.1080/14786410802696684

(DOI: 10.1080/14786410802696684, PubMed: 20954085) Xiong Juan, Yoshiki Kashiwada, Chen Chin-Ho, Qian Keduo, Morris-Natschke L. Susan, Lee Kuo-Hsiung and Yoshihisa Takaishi :
Conjugates of Betulin Derivatives with AZT as Potent Anti-HIV Agents.,
Bioorganic & Medicinal Chemistry, Vol.18, No.17, 6451-6469, 2010.

(要約): Fourteen novel conjugates of 3,28-di-O-acylbetulins with AZT were prepared as anti-HIV agents, based on our previously reported potent anti-HIV triterpene leads, including 3-O-acyl and 3,28-di-O-acylbetulins. Nine of the conjugates (49-53, 55, 56, 59, and 60) exhibited potent anti-HIV activity at the submicromolar level, with EC(50) values ranging from 0.040 to 0.098muM in HIV-1(NL4-3) infected MT-4 cells. These compounds were equipotent or more potent than 3-O-(3',3'-dimethylsuccinyl)betulinic acid (2), which is currently in Phase IIb anti-AIDS clinical trial.
(キーワード): Anti-HIV Agents / CD4-Positive T-Lymphocytes / Cell Line / HIV-1 / Humans / Triterpenes / Zidovudine
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.bmc.2010.06.092
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20673723; ● Summary page in Scopus @ Elsevier: 2-s2.0-77955982012

(DOI: 10.1016/j.bmc.2010.06.092, PubMed: 20673723, Elsevier: Scopus) Naonobu Tanaka, Otani Mio, Yoshiki Kashiwada, Yoshihisa Takaishi, Shibazaki Azusa, Gonoi Tohru, Shiro Motoo and Kobayashi Junichi :
Petiolins J-M, prenylated acylphloroglucinols from Hypericum pseudopetiolatum var. kiusianum.,
Bioorganic & Medicinal Chemistry Letters, Vol.20, No.15, 4451-4455, 2010.

(要約): Four new prenylated acylphloroglucinols, petiolins J-M (1-4), were isolated from aerial parts of Hypericum pseudopetiolatum var. kiusianum, and the structures were elucidated by spectroscopic data and a single-crystal X-ray diffraction analysis. Petiolin J (1) exhibited antimicrobial activity.
(キーワード): Anti-Bacterial Agents / Cell Line / Crystallography, X-Ray / Humans / Hypericum / Magnetic Resonance Spectroscopy / Microbial Sensitivity Tests / Molecular Conformation / Phloroglucinol / Prenylation
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.bmcl.2010.06.047
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20598881; ● Search Scopus @ Elsevier (PMID): 20598881; ● Search Scopus @ Elsevier (DOI): 10.1016/j.bmcl.2010.06.047

(DOI: 10.1016/j.bmcl.2010.06.047, PubMed: 20598881) Hiroaki Yanagawa, Junji Terao, Eiji Takeda, Yoshihisa Takaishi, Yoshiki Kashiwada, Kazuyoshi Kawazoe, Fushitani Shuji, Koichiro Tsuchiya, Aiko Yamauchi, Sato Chiho and Minoru Irahara :
Consultation clinics for complementary and alternative medicine at Japanese university hospitals: An analysis at Tokushima University Hospital,
Experimental and Therapeutic Medicine, Vol.1, No.3, 481-483, 2010.

(要約): Here, we report on a Consultation Clinic for Complementary and Alternative Medicine (CAM) which we established at Tokushima University Hospital in July of 2007 with the aim of providing person-to-person information on CAM, though not CAM therapy itself. In December of 2008, we received 55 applications for consultation, 37% concerning health foods, 37% Japanese herbal medicine (Kampo), and 26% various other topics. The consultants (nutritionists and pharmacists) communicated individually with 38 applicants; malignancies (26%) and cardiovascular disease (24%) were the main underlying concerns. To promote the quality of consultation, data was collected by means of focus group interviews concerning the perspective of the consultants. Safe and effective use of CAM requires a network of communication linking individuals, consultation teams, physicians, primary care institutions and university hospitals. To advance this goal, we plan to broaden the efforts described herein. Our findings indicate that the specific role of the consultation clinic in promoting the scientific use of CAM merits further study.
(出版サイトへのリンク): ● Publication site (DOI): 10.3892/etm_00000075
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22993564; ● Search Scopus @ Elsevier (PMID): 22993564; ● Search Scopus @ Elsevier (DOI): 10.3892/etm_00000075

(DOI: 10.3892/etm_00000075, PubMed: 22993564) Shin-ichiro Kurimoto, Mamoru Okasaka, Yoshiki Kashiwada, Olimjon Kodzhimatov and Yoshihisa Takaishi :
A new C14-polyacetylenic glucoside with an -pyrone moiety and four new C10-polyacetylenic glucosides from Mediasia macrophylla,
Phytochemistry, Vol.71, No.5-6, 688-692, 2010.

(要約): Polyacetylenic glucosides (1-5) were isolated from the MeOH extract of Mediasia macrophylla, and their structures were established by spectroscopic analyses. Compounds 2-4 were the first examples of C(10)-polyacetylenic glucosides found in the family Umbelliferae, while compound 1 was a unique polyacetylenic glucoside possessing an alpha-pyrone moiety.
(キーワード): Alkynes / Apiaceae / Glucosides / Molecular Structure / Plant Components, Aerial / Plant Extracts / Pyrones
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.phytochem.2009.12.007
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20074759; ● Search Scopus @ Elsevier (PMID): 20074759; ● Search Scopus @ Elsevier (DOI): 10.1016/j.phytochem.2009.12.007

(DOI: 10.1016/j.phytochem.2009.12.007, PubMed: 20074759) Xiong Juan, Taniguchi Masatoshi, Yoshiki Kashiwada, Sekiya Michiko, Yamagishi Takashi and Yoshihisa Takaishi :
Papyriferic Acid Derivatives as Reversal Agents of Multidrug Resistance in Cancer Cells.,
Bioorganic & Medicinal Chemistry, Vol.18, No.8, 2964-2975, 2010.

(要約): Forty-one derivatives of papyriferic acid were prepared based on our previous finding that methyl papyriferate (3) showed potent reversing effect on cytotoxicity of colchicine against multidrug resistance (MDR) human cancer cells (KB-C2), and evaluated for their cytotoxicity and effect on reversing P-gp-mediated MDR against KB-C2 cells. 3-O-(Morpholino-beta-oxopropanoyl)-12beta-acetoxy-3alpha,25-dihydroxy-(20S,24R)-epoxydammarane (37) significantly increased the sensitivity of colchicine against KB-C2 cells by 185-fold at 5microg/mL (7.4microM), and the cytotoxicity of colchicine was recovered to nearly that of sensitive (KB) cells. The other several new amide derivatives also exhibited potent reversal activity comparable to or more potent than methyl papyriferate and verapamil.
(キーワード): Antineoplastic Agents / Cell Line, Tumor / Drug Resistance, Multiple / Drug Resistance, Neoplasm / Humans / Malonates / Morpholines / P-Glycoprotein / Triterpenes
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.bmc.2010.02.046
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20363142; ● Search Scopus @ Elsevier (PMID): 20363142; ● Search Scopus @ Elsevier (DOI): 10.1016/j.bmc.2010.02.046

(DOI: 10.1016/j.bmc.2010.02.046, PubMed: 20363142) Naonobu Tanaka, Mamemura Takuji, Abe Shuhei, Imabayashi Kiyoshi, Yoshiki Kashiwada, Yoshihisa Takaishi, Suzuki Tetsuro, Takebe Yutaka, Kubota Takaaki and Kobayashi Junichi :
Biyouxanthones A-D, prenylated xanthones from roots of Hypericum chinense,
Heterocycles, Vol.80, No.1, 613-621, 2010.

(キーワード): Hypericum chinense / Prenylated Xanthone / Antiviral Activity / Hepatitis C Virus / Clusiaceae
(出版サイトへのリンク): ● Publication site (DOI): 10.3987/COM-09-S(S)28
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1523388080321984000; ● Search Scopus @ Elsevier (DOI): 10.3987/COM-09-S(S)28

(DOI: 10.3987/COM-09-S(S)28, CiNii: 1523388080321984000) Naonobu Tanaka, Takaaki Kubota, Yoshiki Kashiwada, Yoshihisa Takaishi and Jun'ichi Kobayashi :
Petiolins F-I, benzophenone rhamnosides from Hypericum pseudopetiolatum var. kiusianum.,
Chemical & Pharmaceutical Bulletin, Vol.57, No.10, 1171-1173, 2009.

(要約): Four new benzophenone-O-rhamnosides, petiolins F-I (1-4), were isolated from aerial parts of Hypericum pseudopetiolatum var. kiusianum, and the structures were elucidated by spectroscopic data and chemical means.
(キーワード): Benzophenones / Hypericum / 核磁気共鳴分光法 (nuclear magnetic resonance spectroscopy) / Molecular Conformation / Phloroglucinol
(出版サイトへのリンク): ● Publication site (DOI): 10.1248/cpb.57.1171
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19801884; ● Search Scopus @ Elsevier (PMID): 19801884; ● Search Scopus @ Elsevier (DOI): 10.1248/cpb.57.1171

(DOI: 10.1248/cpb.57.1171, PubMed: 19801884) Naonobu Tanaka, Yoshiki Kashiwada, Sang-Yong Kim, Michiko Sekiya, Yasumasa Ikeshiro and Yoshihisa Takaishi :
Xanthones from Hypericum chinense and their cytotoxicity evaluation.,
Phytochemistry, Vol.70, No.11-12, 1456-1461, 2009.

(要約): A xanthonolignoid, 2-O-demethylkielcorin, and a phenylxanthone, chinexanthone A, were isolated from stems of Hypericum chinense together with four known xanthonolignoids and seven known xanthones. Their structures were established by spectroscopic analysis, as their optical properties and absolute stereochemistry determined. The cytotoxicities of the isolated xanthone derivatives as well as additional 32 xanthones against a panel of human cancer cell lines were also evaluated.
(キーワード): Antineoplastic Agents, Phytogenic / Cell Line, Tumor / Humans / Hypericum / 分子構造 (molecular structure) / Neoplasms / Phytotherapy / Plant Extracts / Plant Stems / Xanthones
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.phytochem.2009.08.015
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19766276; ● Search Scopus @ Elsevier (PMID): 19766276; ● Search Scopus @ Elsevier (DOI): 10.1016/j.phytochem.2009.08.015

(DOI: 10.1016/j.phytochem.2009.08.015, PubMed: 19766276) Naonobu Tanaka, Yoshiki Kashiwada, Sang Yong Kim, Waka Hashida, Michiko Sekiya, Yasumasa Ikeshiro and Yoshihisa Takaishi :
Acylphloroglucinol, biyouyanagiol, biyouyanagin B, and related spiro-lactones from Hypericum chinense.,
Journal of Natural Products, Vol.72, No.8, 1447-1452, 2009.

(要約): Biyouyanagiol (1), an acylphloroglucinol-related compound having a unique cyclopenta-1,3-dione moiety, was isolated from a Japanese traditional medicinal plant, Hypericum chinense, together with three new spiro-lactone-related derivatives, biyouyanagin B (2), 5,6-dihydrohyperolactone D (3), and 4-hydroxyhyperolactone D (4). Their structures were established on the basis of spectroscopic evidence. In a cytotoxicity assay against human cancer cell lines including multidrug-resistant (MDR) cancer cell lines, several compounds demonstrated enhanced cytotoxicity against MDR KB cells in the presence of colchicine.
(キーワード): Antineoplastic Agents, Phytogenic / Colchicine / Drug Resistance, Multiple / Drug Screening Assays, Antitumor / Humans / Hypericum japonicus / KB Cells / Lactones / Molecular Structure / Plant Leaves / Plants, Medicinal / Sesquiterpenes / Spiro Compounds
(出版サイトへのリンク): ● Publication site (DOI): 10.1021/np900109y
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19606850; ● Search Scopus @ Elsevier (PMID): 19606850; ● Search Scopus @ Elsevier (DOI): 10.1021/np900109y

(DOI: 10.1021/np900109y, PubMed: 19606850) Sang-Yong Kim, Yoshiki Kashiwada, Kazuyoshi Kawazoe, Kotarou Murakami, Han-Dong Sun, Shun-Lin Li and Yoshihisa Takaishi :
Spicachlorantins A and B, New Dimeric Sesquiterpenes from the roots of Chloranthus spicatus.,
Phytochemistry Letters, Vol.2, No.3, 110-113, 2009.

(キーワード): Chloranthaceae / Chloranthus spicatus / Ethnopharmacology / Dimeric lindenane sesquiterpene
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.phytol.2009.03.001
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1016/j.phytol.2009.03.001

(DOI: 10.1016/j.phytol.2009.03.001) Jun-Yi Hu, Zhi Yao, Ying-Qian Xu, Yoshihisa Takaishi and Hong-Quan Duan :
Triterpenes from Astilbe chinensis.,
Journal of Asian Natural Products Research, Vol.11, No.3, 236-242, 2009.

(要約): Six new triterpenes, 3beta,6beta-dihydroxyurs-12-en-27-oic acid (1), 3beta,6beta,24-trihydroxyurs-12-en-27-oic acid (2), 3beta,6beta,7alpha-trihydroxyurs-12-en-27-oic acid (3), 3beta-acetoxy-6beta-hydroxyurs-12-en-27-oic acid (4), 3beta,6beta,24-trihydroxyolean-12-en-27-oic acid (5), and 3beta,6beta,7alpha-trihydroxyolean-12-en-27-oic acid (6), were isolated from the rhizomes of Astilbe chinensis. Their structures were elucidated on the basis of 1D- and 2D-NMR analyses and HR-MS experiments. The isolated compounds exhibited significant cytotoxic activities against the SK-N-SH and HL-60 cell lines.
(キーワード): Drugs, Chinese Herbal / HL-60 Cells / Humans / Molecular Structure / Rhizome / Saxifragaceae / Triterpenes
(出版サイトへのリンク): ● Publication site (DOI): 10.1080/10286020802682866
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19408147; ● Search Scopus @ Elsevier (PMID): 19408147; ● Search Scopus @ Elsevier (DOI): 10.1080/10286020802682866

(DOI: 10.1080/10286020802682866, PubMed: 19408147) Jin-Bo Fang, Zhi Yao, Jia-Chun Chen, Yan-Wen Liu, Yoshihisa Takaishi and Hong-Quan Duan :
Cytotoxic triterpene saponins from Alternanthera philoxeroides.,
Journal of Asian Natural Products Research, Vol.11, No.3, 261-266, 2009.

(要約): Four new pentacyclic triterpene saponins, philoxeroidesides A-D (1-4) were isolated from the aerial parts of Alternanthera philoxeroides. Their structures were elucidated on the basis of 1D- and 2D-NMR experiments and MS analyses. Philoxeroidesides A-D (1-4) showed cytotoxic activities against SK-N-SH and HL60 cell lines.
(キーワード): Amaranthaceae / Antineoplastic Agents, Phytogenic / Drug Screening Assays, Antitumor / Drugs, Chinese Herbal / HL-60 Cells / Humans / Molecular Structure / Nuclear Magnetic Resonance, Biomolecular / Saponins / Triterpenes
(出版サイトへのリンク): ● Publication site (DOI): 10.1080/10286020802684656
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19408151; ● Search Scopus @ Elsevier (PMID): 19408151; ● Search Scopus @ Elsevier (DOI): 10.1080/10286020802684656

(DOI: 10.1080/10286020802684656, PubMed: 19408151) Naonobu Tanaka, Kubota Takaaki, Ishiyama Haruaki, Yoshiki Kashiwada, Yoshihisa Takaishi, Ito Junji, Mikami Yuzuru, Shiro Motoo and Kobayashi Jun'ichi :
Petiolins D and E, phloroglucinol derivatives from Hypericum pseudopetiolatum var. kiusianum.,
Heterocycles, Vol.79, No.1, 917-924, 2009.

(キーワード): Hypericum pseudopetiolatum var. kiusianum / Phloroglucinol Derivative / Chromone Glucoside / Clusiaceae
(出版サイトへのリンク): ● Publication site (DOI): 10.3987/COM-08-S(D)64
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1520291853589647488; ● Search Scopus @ Elsevier (DOI): 10.3987/COM-08-S(D)64

(DOI: 10.3987/COM-08-S(D)64, CiNii: 1520291853589647488) Naonobu Tanaka, Yoshiki Kashiwada, Tatsuro Nakano, Hirofumi Shibata, Tomihiko Higuchi, Michiko Sekiya, Yasumasa Ikeshiro and Yoshihisa Takaishi :
Chromone and chromanone glucosides from Hypericum sikokumontanum and their anti-Helicobacter pylori activities.,
Phytochemistry, Vol.70, No.1, 141-146, 2009.

(要約): Chromone glucosides, takanechromones A-C (1, 2 and 5) and chromanone glucosides, named takanechromanones A and B (3 and 4), were isolated from the methanolic extracts of Hypericumsikokumontanum together with 27 known compounds. Their structures were established based on spectroscopic evidence. The isolated compounds and some chromone derivatives were assayed for antimicrobial activity against Helicobacter pylori and cytotoxicity against human cancer cell lines.
(キーワード): Anti-Bacterial Agents / Antineoplastic Agents, Phytogenic / Cell Line, Tumor / Chromones / Glucosides / Helicobacter pylori / Humans / Hypericum
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.phytochem.2008.11.006
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19121528; ● Search Scopus @ Elsevier (PMID): 19121528; ● Search Scopus @ Elsevier (DOI): 10.1016/j.phytochem.2008.11.006

(DOI: 10.1016/j.phytochem.2008.11.006, PubMed: 19121528) Sang-Yong Kim, Yoshiki Kashiwada, Kazuyoshi Kawazoe, Kotarou Murakami, Han-Dong Sun, Shun-Lin Li and Yoshihisa Takaishi :
Spicachlorantins CF, hydroperoxy dimeric sesquiterpenes from the roots of Chloranthus spicatus.,
Tetrahedron Letters, Vol.50, No.44, 6032-6035, 2009.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.tetlet.2009.08.026
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1016/j.tetlet.2009.08.026

(DOI: 10.1016/j.tetlet.2009.08.026) Freddy Ramos, Yoshihisa Takaishi, Yoshiki Kashiwada, Coralia Osorio, Carmenza Duque, Ricardo Acuna and Yoshinori Fujimoto :
Ent-3,4-seco-labdane and ent-labdane diterpenoids from Croton stipuliformis (Euphorbiaceae),
Phytochemistry, Vol.69, No.12, 2406-2410, 2008.

(要約): From a methanolic extract of the leaves of Croton stipuliformis, three ent-3,4-seco-labdanes (1-3) and an ent-labdane (4) together with the known compounds 6-hydroxynidorellol (5), maravuic acid, and sitosterol were isolated and identified from their spectroscopic data. The absolute stereochemistry of compound 4 was determined by application of Mosher's method in the NMR tube.
(キーワード): Croton / Diterpenes / Models, Molecular / Plant Leaves / Terpenes
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.phytochem.2008.05.025
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18664395; ● Search Scopus @ Elsevier (PMID): 18664395; ● Search Scopus @ Elsevier (DOI): 10.1016/j.phytochem.2008.05.025

(DOI: 10.1016/j.phytochem.2008.05.025, PubMed: 18664395) Waka Hashida, Naonobu Tanaka, Yoshiki Kashiwada, Michiki Sekiya, Yasumasa Ikeshiro and Yoshihisa Takaishi :
Tomoenones A-H, cytotoxic phloroglucinol derivatives from Hypericum ascyron,
Phytochemistry, Vol.69, No.11, 2225-2230, 2008.

(要約): Phloroglucinol derivatives tomoeones A-H (1-8) and three known compounds were isolated from leaves of Hypericum ascyron. Their structures were established based on spectroscopic analyses. They are all acylphloroglucinol derivatives possessing a spiro skeleton with geminal isoprenyl groups and a monoterpene moiety, and they are stereoisomers to each other at C-4 and C-13. They appear to be a class of phloroglucinol derivatives. Cytotoxicities of the isolated phloroglucinol derivatives against human tumor cell lines, including multidrug-resistant (MDR) cancer cell lines, were evaluated. Tomoeone F (6) demonstrated significant cytotoxicity against KB cells with an IC50 value of 6.2 microM. Compound 6 was also cytotoxic against MDR cancer cell lines (KB-C2 and K562/Adr), which was more potent than doxorubicin.
(キーワード): Cell Line, Tumor / Cell Survival / Humans / Hypericum / Magnetic Resonance Spectroscopy / Molecular Structure / Phloroglucinol / Structure-Activity Relationship
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.phytochem.2008.04.026
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18556029; ● Search Scopus @ Elsevier (PMID): 18556029; ● Search Scopus @ Elsevier (DOI): 10.1016/j.phytochem.2008.04.026

(DOI: 10.1016/j.phytochem.2008.04.026, PubMed: 18556029) Chika Hashida, Naonobu Tanaka, Yoshiki Kashiwada, Makoto Ogawa and Yoshihisa Takaishi :
Prenylated Phrologrucinol Derivatives from Hypericum perforatum var. angustifolium,
Chemical & Pharmaceutical Bulletin, Vol.56, No.8, 1164-1167, 2008.

(要約): Two new prenylated phloroglucinol derivatives and 15 known compounds were isolated from the aerial parts of Hypericum perforatum var. angustifolium. Their structures were determined on the basis of spectroscopic evidence.
(キーワード): Hypericum / Phloroglucinol / Prenylation
(出版サイトへのリンク): ● Publication site (DOI): 10.1248/cpb.56.1164
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18670119; ● Search Scopus @ Elsevier (PMID): 18670119; ● Search Scopus @ Elsevier (DOI): 10.1248/cpb.56.1164

(DOI: 10.1248/cpb.56.1164, PubMed: 18670119) Pu Liu, Zhi Yao, Wen Zhang, Yoshihisa Takaishi and Hong-Quan Duan :
Novel Nortriterpenes from Phlomis umbrosa.,
Chemical & Pharmaceutical Bulletin, Vol.56, No.7, 951-955, 2008.

(要約): We isolated 8 novel 28-noroleanane-derived spirocyclic triterpenoids with unusual skeleton structures, phlomisone (1), phlomistetraol A (2), phlomistetraol B (3), phlomistetraol C (4), phlomispentaol (5), phlomishexaol A (6), phlomishexaol B (7), and phlomisin (8), from the ethanol extract of Phlomis umbrosa rhizomes. Their structures were elucidated on the basis of spectroscopic methods, including 1D, 2D nuclear magnetic resonance (NMR), high-resolution mass spectrometry (HR-MS), and X-ray analyses. Compounds 1-3, 5, and 7 exhibited positive cytotoxic activities against the carcinoma cell lines Hela and L929 in vitro, and these bioactive data suggested that the C-18 and C-21 positions had oxygenated functions that can improve the activity of the compound.
(キーワード): Antineoplastic Agents, Phytogenic / Cell Line, Tumor / Humans / Magnetic Resonance Spectroscopy / Mass Spectrometry / Phlomis / Triterpenes
(出版サイトへのリンク): ● Publication site (DOI): 10.1248/cpb.56.951
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18591808; ● Search Scopus @ Elsevier (PMID): 18591808; ● Search Scopus @ Elsevier (DOI): 10.1248/cpb.56.951

(DOI: 10.1248/cpb.56.951, PubMed: 18591808) Naonobu Tanaka, Takaaki Kubota, Haruaki Ishiyama, Atsushi Araki, Yoshiki Kashiwada, Yoshihisa Takaishi, Yuzuru Mikami and Jun'ichi Koyayashi :
Petiolins A-C, phloroglucinol derivatives from Hypericum pseudopetiolatum var. kiusianum,
Bioorganic & Medicinal Chemistry, Vol.16, No.10, 5619-5623, 2008.

(要約): Two new phloroglucinol derivatives possessing chromane skeleton, petiolins A (1) and B (2), and a new phloroglucinol derivative containing a dihydrofuran ring, petiolin C (3), were isolated from aerial parts of Hypericum pseudopetiolatum var. kiusianum. The gross structures of 1-3 were elucidated by spectroscopic data, and the relative stereochemistry of 3 was elucidated by NOESY data. Petiolins A-C (1-3) showed modest cytotoxicity, while petiolin C (3) exhibited antifungal activity.
(キーワード): Animals / Antifungal Agents / Cell Line, Tumor / Cell Proliferation / Drug Screening Assays, Antitumor / Humans / Hypericum / Leukemia L1210 / Magnetic Resonance Spectroscopy / Mice / Microbial Sensitivity Tests / Models, Molecular / Molecular Structure / Phloroglucinol / Stereoisomerism / Trichophyton
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.bmc.2008.03.076
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18430575; ● Search Scopus @ Elsevier (PMID): 18430575; ● Search Scopus @ Elsevier (DOI): 10.1016/j.bmc.2008.03.076

(DOI: 10.1016/j.bmc.2008.03.076, PubMed: 18430575) Mamoru Okasaka, Yoshiki Kashiwada, Olimjon K. Kodzhimatov, Ozodbek Ashurmetov and Yoshihisa Takaishi :
Monoterpene glycosides from Paeonia hybrida,
Phytochemistry, Vol.69, No.8, 1767-1772, 2008.

(要約): Monoterpene glycosides (1-5, and 7), together with 14 known compounds, were isolated from the methanol extract of the roots of Paeonia hybrida. These compounds included a paeoniflorin-related glycoside with a hybrid structure of paeoniflorin and paeonovicinoside (1), a monoterpene glucoside biogenetically related to lactiflorin (2), a paeoniflorin-related monoterpene (3), arbiflorin-related monoterpenes (4 and 5), and a tymol-related monoterpene glycoside (7). Their structures were elucidated by extensive spectroscopic examinations.
(キーワード): Benzoic Acids / Bridged Compounds / Glucosides / Glycosides / Magnetic Resonance Spectroscopy / Medicine, Chinese Traditional / Methanol / Molecular Structure / Paeonia / Plant Roots / Terpenes
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.phytochem.2008.02.016
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18400238; ● Search Scopus @ Elsevier (PMID): 18400238; ● Search Scopus @ Elsevier (DOI): 10.1016/j.phytochem.2008.02.016

(DOI: 10.1016/j.phytochem.2008.02.016, PubMed: 18400238) Naonobu Tanaka, Yoshiki Kashiwada, Michiko Sekiya, Yasumasa Ikeshiro and Yoshihisa Takaishi :
Takaneones A-C, prenylated butylphloroglucinol derivatives from Hypercum shikokumontanum,
Tetrahedron Letters, Vol.49, No.17, 2799-2803, 2008.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.tetlet.2008.02.121
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1016/j.tetlet.2008.02.121

(DOI: 10.1016/j.tetlet.2008.02.121) Shunsuke Ishida, Mamoru Okasaka, Freddy A. Ramos, Yoshiki Kashiwada, Yoshihisa Takaishi, Olimjon K. Kodzhimatov and Ozodbek Ashumetov :
New Alkaloid from the aerial parts of Condonopsis clematidea,
Journal of Natural Medicines, Vol.62, No.2, 236-238, 2008.

(要約): A new codonopsine-related alkaloid and 13 known compounds were isolated from the aerial parts of Codonopsis clematidea (Campanulaceae). The structure of the new compound was elucidated by two-dimensional nuclear magnetic resonance and other spectral examinations.
(キーワード): Alkaloids / Anisoles / Chromatography, High Pressure Liquid / Codonopsis / Magnetic Resonance Spectroscopy / Plant Components, Aerial / Plant Extracts / Pyrrolidines
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s11418-007-0219-7
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18404331; ● Search Scopus @ Elsevier (PMID): 18404331; ● Search Scopus @ Elsevier (DOI): 10.1007/s11418-007-0219-7

(DOI: 10.1007/s11418-007-0219-7, PubMed: 18404331) Yoshio Takeda, Maki Tomonari, Shihoko Arimoto, Toshiya Masuda, Hideaki Otsuka, Katsuyoshi Matsunami, Gisho Honda, Michiho Ito, Yoshihisa Takaishi, Fumiyuki Kiuchi, Olimjon K. Khodzhimatov and Ozodbek A. Ashurmetov :
A new phenolic glucoside from an Uzbek medicinal plant, Origanum tyttanthum,
Journal of Natural Medicines, Vol.62, No.1, 71-74, 2008.

(要約): A new phenolic glucoside was isolated from the aerial parts of Origanum tyttanthum, an Uzbek medicinal plant, together with 12 known compounds. The structure of the new compound was elucidated as 4-O-beta-D-glucopyranosylbenzyl-3'-hydroxyl-4'-methoxybenzoate (1) based on the spectral and chemical evidence.
(キーワード): Glucosides / Magnetic Resonance Spectroscopy / Origanum / Phenols / Plant Components, Aerial / Plants, Medicinal / Uzbekistan
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s11418-007-0187-y
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18404346; ● Search Scopus @ Elsevier (PMID): 18404346; ● Search Scopus @ Elsevier (DOI): 10.1007/s11418-007-0187-y

(DOI: 10.1007/s11418-007-0187-y, PubMed: 18404346) Michiko Sekiya, Yoshiki Kashiwada, Tomohiro Nabekura, Shuji Kitagawa, Takashi Yamagishi, Takako Yokozawa, Takashi Ichiyanagi, Yasumasa Ikeshiro and Yoshihisa Takaishi :
Effect of Triterpenoids from the Floral Spikes of Betula platyphylla var. japonica on Glycoprotein Function,
Planta Medica, Vol.73, No.15, 1558-1562, 2007.

(要約): One of the major causes of multidrug resistance (MDR) in cancer cells is over-expression of P-glycoprotein (P-gp). We studied the effects of 20 triterpenes isolated from the floral spikes of Betula platyphylla var. japonica ( B. platyphylla) on P-gp function based on our previous finding that some of them showed MDR reversing effects. We evaluated accumulations and effluxes of rhodamine 123 as a P-gp substrate with P-gp over-expressing KB-C2 cells. Among the 20 triterpenes, compounds 3, 4, 8, 9, 13, 15, and 20 increased rhodamine 123 accumulations in KB-C2 cells, and three ( 8, 13, and 20) of them also inhibited efflux of rhodamine 123 out of cells. In addition, compounds 13 and 20 showed a weak inhibitory activity of P-gp ATPase. These results suggested that MDR reversing effects of compounds 13 and 20 are partly involved in inhibition of P-gp ATPase.
(キーワード): Antineoplastic Agents, Phytogenic / Betula / Cell Line, Tumor / Drug Resistance, Neoplasm / Flowering Tops / Fluorescent Dyes / Humans / P-Glycoprotein / Phytotherapy / Plant Extracts / Rhodamine 123 / Triterpenes
(出版サイトへのリンク): ● Publication site (DOI): 10.1055/s-2007-993745
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18058609; ● Search Scopus @ Elsevier (PMID): 18058609; ● Search Scopus @ Elsevier (DOI): 10.1055/s-2007-993745

(DOI: 10.1055/s-2007-993745, PubMed: 18058609) Wen Zhou, Hongru Li, Shufen Li, 高石喜久, Hongquan Duan :
Study on chromatographic fingerprint of extractive from Tripterygium wilfordii with supercritical carbon dioxide.,
China Journal of Chinese Materia Medica, Vol.32, No.8, 706-709, 2007年.

(要約): To establish the chromatographic fingerprint of supercritical carbon dioxide extract of Tripterygium wilfordii. HPLC method was applied for quality assessment of T. Wilfordii, HPLC analysis was performed on Kromasil C18 (4. 6 mm x 250 mm, 5 microm) with the mixture of acetonitrile-1% per thousand H3PO4, as mobile phase in gradient mode. The samples were detected at UV of 267 nm with column temperature of 35 degrees C, analytic time was 80 min; Flow-rate was 1.0 mL x min(-1). The chromatographic fingerprint of ten batches of samples was determined, for establishing the chromatographic fingerprint of T. Wilfordii. Indicating 27 peaks in common, identified 21 peaks with chemical reference and HPLC-MS, and the HPLC fingerprint was established. The method is steady and accurate with a good repeatability and can be used as a quality control method for T. Wilfordii.
(キーワード): Carbon Dioxide / Chromatography, High Pressure Liquid / Chromatography, Supercritical Fluid / Plant Extracts / Plant Roots / Plants, Medicinal / Reproducibility of Results / Spectrometry, Mass, Electrospray Ionization / Tripterygium
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 17608226; ● Search Scopus @ Elsevier (PMID): 17608226

(PubMed: 17608226) Kyoko Suzuki, Mamoru Okasaka, Yoshiki Kashiwada, Yoshihisa Takaishi, Gisho Honda, Michiho Ito, Yoshio Takeda, Olimjon K. Kodshimatov, Ozodbek Ashurmetov, Michiko Sekiya and Yasumasa Ikeshiro :
Sesquiterpene Lactone from the Roots of Ferula varia and Their Cytotoxic Activity,,
Journal of Natural Products, Vol.70, No.12, 1915-1918, 2007.

(要約): The ethyl acetate-soluble fraction from a MeOH extract of the roots of Ferula varia gave six new sesquiterpene lactones (1-6) and five known sesquiterpenes (7-11). Their structures were established on the basis of spectroscopic evidence. The cytotoxic activities of 1-11 were evaluated against selected human cancer cell lines. Compound 4 showed significant selective cytotoxicity against multidrug-resistant cancer cells (KB-C2). The cytotoxicities of compounds 1, 3, 5, 8, and 11 against KB-C2 cells were enhanced in the presence of nontoxic concentrations of colchicine.
(キーワード): Antineoplastic Agents, Phytogenic / Colchicine / Drug Resistance, Multiple / Drug Resistance, Neoplasm / Drug Screening Assays, Antitumor / Ferula / Humans / KB Cells / Lactones / Molecular Structure / Plant Roots / Plants, Medicinal / Sesquiterpenes / Uzbekistan
(出版サイトへのリンク): ● Publication site (DOI): 10.1021/np0703996
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18052129; ● Search Scopus @ Elsevier (PMID): 18052129; ● Search Scopus @ Elsevier (DOI): 10.1021/np0703996

(DOI: 10.1021/np0703996, PubMed: 18052129) Waka Hashida, Naonobu Tanaka and Yoshihisa Takaishi :
Prenylated xanthones from Hypericum ascyron,
Journal of Natural Medicines, Vol.61, No.4, 371-374, 2007.

(キーワード): Clusiaceae / Prenylated xanthone / Hypericum ascyron / Xanthone
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s11418-007-0152-9
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1523951030165167872; ● Search Scopus @ Elsevier (DOI): 10.1007/s11418-007-0152-9

(DOI: 10.1007/s11418-007-0152-9, CiNii: 1523951030165167872) Chan Ming Li, Zhi Yao, Wen Yan Zhang, Yoshihisa Takaishi and Quan Hong Duan :
A novel chalcone derivative from Onychium japonicum.,
Chinese Chemical Letters, Vol.18, No.7, 840-842, 2007.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.cclet.2007.05.033
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1016/j.cclet.2007.05.033

(DOI: 10.1016/j.cclet.2007.05.033) Ying-Qian Xu, Zhi Yao, Jun-Yi Hu, Jie Teng, Yoshihisa Takaishi and Hong-Quan Duan :
Immunosuppressive terpenes from Prinsepia utilis.,
Journal of Asian Natural Products Research, Vol.9, No.6-8, 637-642, 2007.

(要約): Two new hemiterpenes, utililactone (1) and epiutililactone (2), along with nine known compounds (3-11), were isolated from the leaves of Prinsepia utilis. Their structures were elucidated on the basis of spectroscopic data. The isolated compounds showed significant immunosuppressive activities.
(キーワード): Immunosuppressive Agents / Magnetic Resonance Spectroscopy / Rosaceae / Spectrometry, Mass, Electrospray Ionization / Spectrophotometry, Infrared / Terpenes
(出版サイトへのリンク): ● Publication site (DOI): 10.1080/10286020600979589
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 17943558; ● Search Scopus @ Elsevier (PMID): 17943558; ● Search Scopus @ Elsevier (DOI): 10.1080/10286020600979589

(DOI: 10.1080/10286020600979589, PubMed: 17943558) Pu Liu, Jie Teng, Yanwen Zhang, 高石喜久, Hongyuan Duan :
Chemical constituents from rhizome of Phlomis umbrosa.,
Yao Xue Xue Bao, Vol.42, No.4, 401-404, 2007年.

(要約): Phlomis umbrosa is a traditional medicinal plant, distributed in the north of China. In the west of Hubei province, its roots were used in the treatment of the rheumatic diseases in Tujia nationality. To study the chemical constituents from the rhizome of Phlomis umbrosa chemical constituents were isolated from the plant by using repeated silica gel, toyopearl HW-40 and preparative HPLC chromatography. The structures of the compounds were elucidated on the basis of one and two dimensional NMR spectroscopic techniques and HRESI-MS. Ten compounds, 6"-syringyl-sesamoside (1), decaffeoylverbascoside (2), calcelarioside B (3), verbascoside (4), isoverbascoside (5), alyssonoside (6), sesamoside (7), shanzhiside methyl ester (8), 8-acetyl-shanzhiside methyl ester (9), 7-epiphlomiol (10) were isolated from P. umbrosa. Compound 1 is a new compound. Compounds 2-6 are isolated from this plant for the first time.
(キーワード): Chromatography, High Pressure Liquid / Glucosides / Glycosides / Magnetic Resonance Spectroscopy / Molecular Conformation / Molecular Structure / Phenols / Phlomis / Plants, Medicinal / Rhizome / Spectrophotometry, Infrared / Spectrophotometry, Ultraviolet
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 17633208; ● Summary page in Scopus @ Elsevier: 2-s2.0-34249904154

(PubMed: 17633208, Elsevier: Scopus) Yoshiki Kashiwada, Michiko Sekiya, Kimihisa Yamazaki, Yasumasa Ikeshiro, Toshihiro Fujioka, Takashi Yamagishi, Shuji Kitagawa and Yoshihisa Takaishi :
Triterpenoids from the Floral Spikes of Betula platyphylla var. japonica and Their Reversing Activity against Multidrug-Resistant Cancer Cells,
Journal of Natural Products, Vol.70, No.4, 623-627, 2007.

(要約): Four new triterpenes, together with 16 known triterpenes, were isolated from the floral spikes of Betula platyphylla var. japonica in a search for compounds capable of reversing multidrug resistance in cancer cells. The structures of the new triterpenes were elucidated as 3,4-seco-olean-4(23),13(18)-dien-3-oic acid (1), 3,4-seco-urs-4(23),20(30)-dien-3-oic acid (2), 3-O-methylmalonylepiocotillol II (6), and 3-O-methylmalonylcabraleahydroxylactone (16) by spectroscopic examination. The cytotoxicity of the isolated triterpenes against human cancer cell lines as well as multidrug-resistant cancer cell lines was evaluated. Most of the isolated triterpenes showed very weak cellular toxicities. Although no discernible differences were found in the cytotoxicities for the tested compounds against sensitive and resistant cell lines, the cytotoxicities for several triterpenes against multidrug-resistant cancer cell lines (KB-C2 or K562/Adr) were enhanced in the presence of nontoxic concentrations of colchicine or doxorubicin. Compound 10 reversed the cytotoxicity of colchicine against KB-C2 cells at 8.1 microM and showed comparable potency to 5 microM verapamil.
(キーワード): Antineoplastic Agents, Phytogenic / Betula / Colchicine / Drug Resistance, Multiple / Drug Resistance, Neoplasm / Drug Screening Assays, Antitumor / Humans / Japan / KB Cells / Molecular Structure / Triterpenes
(出版サイトへのリンク): ● Publication site (DOI): 10.1021/np060631s
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 17346076; ● Search Scopus @ Elsevier (PMID): 17346076; ● Search Scopus @ Elsevier (DOI): 10.1021/np060631s

(DOI: 10.1021/np060631s, PubMed: 17346076) Yoshio Takeda, Takaaki Hayashi, Toshiya Masuda, Gisho Honda, Yoshihisa Takaishi, Michiho Ito, Hideaki Otsuka, Katsuyoshi Matsunami, O.K. Khodzhimatov and O.A. Ashurmetov :
Chemical constituents of an Uzbek medicinal plant, Perovskia scrophularifolia,
Journal of Natural Medicines, Vol.61, No.1, 84-85, 2007.

(キーワード): Perovskia scrophularifolia / Labiatae / Diterpene / Flavone / Glycoside
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s11418-006-0023-9
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1571698600299088128; ● Search Scopus @ Elsevier (DOI): 10.1007/s11418-006-0023-9

(DOI: 10.1007/s11418-006-0023-9, CiNii: 1571698600299088128) Naonobu Tanaka and Yoshihisa Takaishi :
Xanthones from Stems of Hypericum chinense,
Chemical & Pharmaceutical Bulletin, Vol.55, No.1, 19-21, 2007.

(要約): Six new xanthones, 4,6-dihydroxy-2,3-dimethoxyxanthone (1), 2,6-dihydroxy-3,4-dimethoxyxanthone (2), 6-hydroxy-2,3,4-trimethoxyxanthone (3), 3,6-dihydroxy-1,2-dimethoxyxanthone (4), 4,7-dihydroxy-2,3-dimethoxyxanthone (5), and 3,7-dihydroxy-2,4-dimethoxyxanthone (6) were isolated from the stems of Hypericum chinense, together with four known xanthones. Their structures were established based on spectroscopic studies.
(キーワード): Chromatography, High Pressure Liquid / Hypericum / Magnetic Resonance Spectroscopy / Plant Stems / Spectrophotometry, Infrared / Xanthones
(出版サイトへのリンク): ● Publication site (DOI): 10.1248/cpb.55.19
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 17202694; ● Search Scopus @ Elsevier (PMID): 17202694; ● Search Scopus @ Elsevier (DOI): 10.1248/cpb.55.19

(DOI: 10.1248/cpb.55.19, PubMed: 17202694) Lin Quan Yu, Quan Hong Duan, Yuan Wen Gao and Yoshihisa Takaishi :
A new triterpene and a saponin from Centella asiatica,
Chinese Chemical Letters, Vol.18, No.1, 62-64, 2007.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.cclet.2006.11.033
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1016/j.cclet.2006.11.033

(DOI: 10.1016/j.cclet.2006.11.033) Pu Liu, Yoshihisa Takaishi and Quan Hong Duan :
Two new phenylethanoid glycosides from the roots of Phlomis umbrosa,
Chinese Chemical Letters, Vol.18, No.2, 155-157, 2007.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.cclet.2006.12.019
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1016/j.cclet.2006.12.019

(DOI: 10.1016/j.cclet.2006.12.019) Deliorman Didem Orhan, Fatma Ergun, Erdem Yesilada, Koichiro Tsuchiya, Yoshihisa Takaishi and Kazuyoshi Kawazoe :
Antioxidant activity of two flavonol glycosides from Cirsium hypoleucum DC. through bioassay-guided fractionation,
Turkish Journal of Pharmaceutical Sciences, Vol.4, No.1, 1-14, 2007.

(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-34250900361

(Elsevier: Scopus) Y.-B. Liu, W. Jia, Z. Yao, Q. Pan, Yoshihisa Takaishi and H.-Q. Duan :
Two eudesmane sesquiterpenes from Laggera pterodonta,
Journal of Asian Natural Products Research, Vol.9, No.3, 233-237, 2007.

(キーワード): Laggera pterodonta / Sesquiterpenes / 2 alpha-hydroxy pterodontic acid / pterodolide / immunosuppressive activity
(出版サイトへのリンク): ● Publication site (DOI): 10.1080/10286020600603924
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1080/10286020600603924

(DOI: 10.1080/10286020600603924) Yunshuang Fan, Wei Jia, Yoshihisa Takaishi and Quan Hong Duan :
Cimigenol-3-O-β-D-xylopyranoside methanol solvate,
Acta Crystallographica. Section E, Structure Reports Online, Vol.E62, No.11, o4884-o4886, 2006.

(出版サイトへのリンク): ● Publication site (DOI): 10.1107/S1600536806040153
(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-33750884381

(DOI: 10.1107/S1600536806040153, Elsevier: Scopus) Mamoru Okasaka, Yoshihisa Takaishi, Yoshiki Kashiwada, K. Olimjon Kodzhimatov, Ozodbek Ashurmetov, J. Ai Lin, Mark L. Consentino and Kuo-Hsiung Lee :
Terpenoids from Juniperus polycarpus var. seravschanica,
Phytochemistry, Vol.67, No.24, 2635-2640, 2006.

(要約): Two eudesmanes, two abietanes, two podocarpanes and other nine known compounds were isolated from the dried fruits of Juniperus polycarpus var. seravschanica. Their structures were established on the basis of analysis of spectroscopic evidence. Some of the isolated terpenoids showed antimalarial activity.
(キーワード): Animals / Antimalarials / Diterpenes / Diterpenes, Abietane / Fruit / Juniperus / Magnetic Resonance Spectroscopy / Molecular Structure / Plant Extracts / Plasmodium falciparum / Sesquiterpenes / Sesquiterpenes, Eudesmane / Terpenes
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.phytochem.2006.07.020
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 16956634; ● Search Scopus @ Elsevier (PMID): 16956634; ● Search Scopus @ Elsevier (DOI): 10.1016/j.phytochem.2006.07.020

(DOI: 10.1016/j.phytochem.2006.07.020, PubMed: 16956634) Yu Quan-Lin, Duan Hong-Quan, Yoshihisa Takaishi and Gao Wen-Yuan :
A Novel Triterpene from Centella asiatica,
Molecules, Vol.11, No.9, 661-665, 2006.

(要約): A novel triterpene, 2alpha,3beta,20,23-tetrahydroxyurs-28-oic acid (1), was isolated from the aerial part of Centella asiatica. Its structure was elucidated by spectroscopic methods, including 2D-NMR spectra. It displayed no activity against Hela and A549 cell lines at concentrations of 10 and 30 microg/mL, respectively.
(キーワード): Antineoplastic Agents, Phytogenic / Centella / Female / HeLa Cells / Humans / Lung Neoplasms / Magnetic Resonance Spectroscopy / Triterpenes / Uterine Cervical Neoplasms
(出版サイトへのリンク): ● Publication site (DOI): 10.3390/11090661
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 17971739; ● Search Scopus @ Elsevier (PMID): 17971739; ● Search Scopus @ Elsevier (DOI): 10.3390/11090661

(DOI: 10.3390/11090661, PubMed: 17971739) Masafumi Horiuch, Chihiro Murakami, Narihiko Fukamiya, Donglei Yu, Tzu-Hsuan Chen, F. Kenneth Bastow, De-Cheng Zhang, Yoshihisa Takaishi, Yasuhiro Imakura and Kuo-Hsiung Lee :
Tripfordines A-C, Sesquiterpene Pyridine Alkaloids from Tripterygium wilfordii, and Structure Anti-HIV Activity Relationships of Tripterygium Alkaloids,
Journal of Natural Products, Vol.69, No.9, 1271-1274, 2006.

(要約): Three new sesquiterpene pyridine alkaloids, tripfordines A-C (1-3), were isolated from an ethanolic extract of the roots of Tripterygium wilfordii, along with eight known pyridine alkaloids, and tested for in vitro cytotoxic and anti-HIV activity. The structures of the new compounds were established on the basis of spectroscopic data interpretation. Anti-HIV structure-activity relationships (SAR) for this compound type are proposed on the basis of the screening results from the newly isolated compounds and prior data of known sesquiterpene pyridine alkaloids. The position of a carboxyalkyl chain on the pyridine moiety was not critical since both 2'- and 4'-substituted compounds exhibited high anti-HIV activity (EC(50) 0.1 microg/mL). In contrast, a hydroxy group at C-8' (carboxypropyl side chain) or C-9' (carboxybutyl side chain) was found to affect anti-HIV activity.
(キーワード): Alkaloids / Anti-HIV Agents / Drugs, Chinese Herbal / Molecular Structure / Plant Bark / Plant Roots / Plants, Medicinal / Pyridines / Sesquiterpenes / Structure-Activity Relationship / Tripterygium
(出版サイトへのリンク): ● Publication site (DOI): 10.1021/np060124a
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 16989518; ● Search Scopus @ Elsevier (PMID): 16989518; ● Search Scopus @ Elsevier (DOI): 10.1021/np060124a

(DOI: 10.1021/np060124a, PubMed: 16989518) Naonobu Tanaka and Yoshihisa Takaishi :
Xanthones from Hypericum chinense,
Phytochemistry, Vol.67, No.19, 2146-2151, 2006.

(要約): Six xanthones, 1,3,7-trihydroxy-2-(2-hydroxy-3-methyl-3-butenyl)-xanthone (1), 1,7-dihydroxy-2,3-[2''-(1-hydroxy-1-methylethyl)-dihydrofurano]-xanthone (2), 1,3,7-trihydroxy-5-methoxyxanthone (3), 1,7-dihydroxy-5,6-dimethoxyxanthone (4), 4,5-dihydroxy-2,3-dimethoxyxanthone (5), 1,3-dihydroxy-2,4-dimethoxyxanthone (6) and 21 known xanthones were isolated from the leaves and stems of Hypericum chinense. Their structures were established based on spectroscopic studies.
(キーワード): Hypericum / Magnetic Resonance Spectroscopy / Molecular Structure / Plant Leaves / Plant Stems / Xanthones
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.phytochem.2006.05.043
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 16884745; ● Search Scopus @ Elsevier (PMID): 16884745; ● Search Scopus @ Elsevier (DOI): 10.1016/j.phytochem.2006.05.043

(DOI: 10.1016/j.phytochem.2006.05.043, PubMed: 16884745) Hiroyuki Nakagawa, Yoshihisa Takaishi, Naonobu Tanaka, Koichiro Tsuchiya, Hirofumi Shibata and Tomihiko Higuti :
Chemical Constituents from the Peels of Citrus sudachi,
Journal of Natural Products, Vol.69, No.8, 1177-1179, 2006.

(要約): A methanol extract of the peels of Citrus sudachi gave five new compounds (1-5) and 27 known compounds. The structures were elucidated on the basis of spectroscopic evidence. Several of these compounds were assayed for antimicrobial activity against methicillin-resistant Staphylococcus aureus and Helicobacter pylori, and sudachitin (6) and 3'-demethoxysudachitin (7) were the most active.
(キーワード): Anti-Bacterial Agents / Citrus / Coumaric Acids / Flavonoids / Fruit / Glycosides / Helicobacter pylori / Japan / Limonins / Methicillin Resistance / Microbial Sensitivity Tests / Plants, Medicinal / Staphylococcus aureus
(出版サイトへのリンク): ● Publication site (DOI): 10.1021/np060217s
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 16933871; ● Search Scopus @ Elsevier (PMID): 16933871; ● Search Scopus @ Elsevier (DOI): 10.1021/np060217s

(DOI: 10.1021/np060217s, PubMed: 16933871) Freddy A. Ramos, Yoshihisa Takaishi, Kazuyoshi Kawazoe, Coralia Osorio, Carmenza Duque, Ricardo Acuna, Yoshinori Fujimoto, Mtsunobu Sato, Masato Okamoto, Tetsuya Oshikawa and S. U. Ahmed :
Immunosuppressive diacetylenes, ceramides and cerebrosides from Hydrocotyle leucocephalata,
Phytochemistry, Vol.67, No.11, 1143-1150, 2006.

(要約): Three C-17 diacetylenic compounds (1-3), one monoterpenoid (4), seven ceramides (leucoceramides A-G, 5a-g), six cerebrosides (leucocerebrosides A-F, 6a-f) and nine known compounds were isolated from the methanolic extract of Hydrocotyle leucocephala. Their structures were established by spectroscopic methods. The isolated compounds 1-3, 5a-g, 6a-f and 7 were shown to be active in the lipopolysaccharide (LPS) induced cytokine production assay for IL-10, IL-12, and TNF-alpha.
(キーワード): Acetylene / Centella / Ceramides / Cerebrosides / Cytokines / Humans / Immunosuppressive Agents / Leukocytes, Mononuclear / Magnetic Resonance Spectroscopy / Molecular Structure / Plant Components, Aerial
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.phytochem.2006.03.004
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 16631830; ● Search Scopus @ Elsevier (PMID): 16631830; ● Search Scopus @ Elsevier (DOI): 10.1016/j.phytochem.2006.03.004

(DOI: 10.1016/j.phytochem.2006.03.004, PubMed: 16631830) Y.-B. Liu, W. Jia, W.-Y. Gao, A.-H. Zhao, Y.-W. Zhang, Yoshihisa Takaishi and H.-Q. Duan :
Two eudesmane sesquiterpenes from Laggera pterodonta,
Journal of Asian Natural Products Research, Vol.8, No.4, 303-307, 2006.

(要約): The phytochemical study of the aerial parts of Laggera pterodonta afforded two new eudesmane sesquiterpenes, 3alpha,4beta,11-trihydroxyenantioeudesmane (pterodontriol E) (1) and 4beta,8beta,11-trihydroxyenantioeudesmane (pterodontriol F) (2), along with seven known compounds. Their structures were elucidated on the basis of spectroscopic data.
(キーワード): Asteraceae / Molecular Structure / Plant Components, Aerial / Sesquiterpenes, Eudesmane
(出版サイトへのリンク): ● Publication site (DOI): 10.1080/10286020500034964
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 16864440; ● Search Scopus @ Elsevier (PMID): 16864440; ● Search Scopus @ Elsevier (DOI): 10.1080/10286020500034964

(DOI: 10.1080/10286020500034964, PubMed: 16864440) Nozomi Komakine, Mamoru Okasaka, Yoshihisa Takaishi, Kazuyoshi Kawazoe, Kotarou Murakami and Yamada Y. :
New dammarane-type saponin from roots of Panax notoginseng,
Natural Medicines, Vol.60, No.2, 135-137, 2006.

(キーワード): Panax notoginseng / Araliaceae / Saponin / Notopanaxoside A
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s11418-005-0016-0
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1523951028253927808; ● Search Scopus @ Elsevier (DOI): 10.1007/s11418-005-0016-0

(DOI: 10.1007/s11418-005-0016-0, CiNii: 1523951028253927808) F.A. Ramos, Yoshihisa Takaishi, M. Shirotori, Y. Kawaguchi, Koichiro Tsuchiya, Hirofumi Shibata, Tomihiko Higuti, T. Tadokoro and M. Takeuchi :
Antibacterial and Antioxidant Activities of Quercetin Oxidation Products from Yellow Onion (Alliu cepa) Skin,
Journal of Agricultural and Food Chemistry, Vol.54, No.10, 3551-3357, 2006.

(要約): Four new quercetin-derived oxidation products (1-4) and lunularin-4-O-beta-D-glucoside (5) were isolated from a water extract of onion (Allium cepa) skin, together with 17 other known compounds. Antibacterial assays for the isolated compounds showed that 2-(3,4-dihydroxyphenyl)-4,6-dihydroxy-2-methoxybenzofuran-3-one (1) presented selective activity against Helicobacter pylori strains and 3-(quercetin-8-yl)-2,3-epoxyflavanone (4) showed antibacterial activity against MRSA and H. pylori strains at the same time that it increased susceptibility of MRSA to beta-lactams. Evaluation of antioxidant activity against DPPH for the isolated compounds showed that the new derivative compounds (1-4) and 2,5,7,3',4'-pentahydroxy-3,4-flavandione (6) are more active than quercetin.
(キーワード): Anti-Bacterial Agents / Antioxidants / Bibenzyls / Biphenyl Compounds / Disk Diffusion Antimicrobial Tests / Glucosides / Helicobacter pylori / Hydrazines / Methicillin-Resistant Staphylococcus aureus / Molecular Structure / Onions / Phenols / Picrates / Plant Extracts
(出版サイトへのリンク): ● Publication site (DOI): 10.1021/jf060251c
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19127724; ● Search Scopus @ Elsevier (PMID): 19127724; ● Search Scopus @ Elsevier (DOI): 10.1021/jf060251c

(DOI: 10.1021/jf060251c, PubMed: 19127724) J.Y. Hu, Z. Yao, J. Teng, Yoshihisa Takaishi and H.Q. Duan :
Two New Triterpenes from Astilbe chinensis,
Chinese Chemical Letters, Vol.17, No.5, 628-630, 2006.

(キーワード): Astilbe chinensis / triterpene / cytotoxic activities
(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-33745845905

(Elsevier: Scopus) Jeong-Yong Cho, Jae-Hak Moon, Hye-Kyung Kim, Seung-Jin Ma, Seon-Jae Kim, Mi-Young Jang, Kazuyoshi Kawazoe, Yoshihisa Takaishi and Keun-Hyung Park :
Isolation and structural elucidation of antimicrobial compounds from buckwheat hull,
Journal of Microbiology and Biotechnology, Vol.16, No.4, 538-542, 2006.

(キーワード): buckwheat hull / Fagopyrum esculentum / antimicrobial compound / 6,7-dihydroxy-3,7-dimethyl-octa-2,4-dienoic acid / 4,7-dihydroxy-3,7-dimethyl-octa-2,5-dienoic acid / ESCULENTUM MOENCH HULLS / ANTIOXIDANT ACTIVITIES / EXTRACT / RICE / DIET
(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-33646594395

(Elsevier: Scopus) K Kondo, Yoshihisa Takaishi, Hirofumi Shibata and Tomihiko Higuti :
ILSMRs (intensifier of β-lactam-susceptibility in methicillin-resistant Staphylococcus aureus) from Tara [Caesalpinia spinosa (Molina) Kuntze],
Phytomedicine, Vol.13, No.3, 209-212, 2006.

(要約): Four quinic acid gallates were isolated from the dried pods of Tara [Caesalpinia spinosa (Molina) Kuntze]. These compounds intensified the susceptibility of methicillin-resistant Staphylococcus aureus (MRSA) to oxacillin. 3,4,5-Tri-O-galloylquinic acid methyl ester (2) was the most effective compound of them.
(キーワード): Caesalpinia spinosa (Tara) / Quinic acid gallates / ILSMR / MRSA
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.phymed.2004.08.001
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 16428032; ● Search Scopus @ Elsevier (PMID): 16428032; ● Search Scopus @ Elsevier (DOI): 10.1016/j.phymed.2004.08.001

(DOI: 10.1016/j.phymed.2004.08.001, PubMed: 16428032) J.Y. Hu, W. Qiao, Yoshihisa Takaishi and H.Q. Duan :
A New Hemiterpene Derivative From Pyinsepia utilis,
Chinese Chemical Letters, Vol.17, No.2, 198-200, 2006.

(キーワード): Prinsepia utilis / hemiterpene / (+)-(2R, 3S)-2-chloro-3-hydroxy-3-methyl-gamma-butyrolactone
(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-33644670343

(Elsevier: Scopus) Xiao-Dong Wang, Wei Jia, Wen-Yuan Gao, Rong Zhang, Yan-Wen Zhang, Jun Zhang, Yoshihisa Takaishi and Hong-Quan Duan :
Terpene alkaloids from Tripterygium wilfordii,
Journal of Asian Natural Products Research, Vol.7, No.5, 755-759, 2005.

(要約): Two new sesquiterpene alkaloids, 1beta-hydroxy-2beta,5alpha,11-triacetoxy-7beta-nicotinoyl-8beta-benzoyl-dihydroagarofuran, and 1beta,5alpha,11-triacetoxy-7beta-nicotinoyl-8beta-benzoyl-dihydroagarofuran were isolated from the xylem of Tripterygium wilfordii, together with six known compounds. Their structures were elucidated on the basis of spectroscopic studies.
(キーワード): ripterygium wilfordii / Xylem / Sesquiterpene alkaloid
(出版サイトへのリンク): ● Publication site (DOI): 10.1080/1028602042000325618
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 16176909; ● Search Scopus @ Elsevier (PMID): 16176909; ● Search Scopus @ Elsevier (DOI): 10.1080/1028602042000325618

(DOI: 10.1080/1028602042000325618, PubMed: 16176909) Kazuyoshi Kawazoe, Mami Tabata, Kotaro Murakami and Yoshihisa Takaishi :
A Novel Drimane-Type Sesquiterpene from Limonium wrightii,
Natural Medicines, Vol.59, No.4, 186-188, 2005.

(要約): A new drimane-type sesquiterpene, (2S^*,6R^*)-2,6-dihydroxyisodrimenin (1) was isolated from the aerial part of a subtropical plant, Limonium wrightii (HANCE) KUNTZE (Plumbaginaceae), along with drimenin (3), hovetrichoside C (10) and six known tyramides (4-9), and the structures were elucidated by spectroscopic methods. Compound 1 is the first example of a 2-hydroxyisodrimenin-type sesquiterpene.
(キーワード): Limonium wrightii / Plumbaginaceae / drimane-type sesquiterpene / 2,6-dihydroxyisodrimenin
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1520009409420784256; ● Summary page in Scopus @ Elsevier: 2-s2.0-23944440884

(CiNii: 1520009409420784256, Elsevier: Scopus) Wataru Sakane, Noriyuki Hara, Yoshinori Fujimoto, Yoshihisa Takaishi, Ricardo Acuña, Coralia Osorio and Carmenza Duque :
Cupaniol, a New Branched Polyprenol, from Cupania latifolia,
Chemical & Pharmaceutical Bulletin, Vol.53, No.8, 1037-1039, 2005.

(要約): A new branched polyprenol, designated cupaniol, has been isolated from the methanol extract of the leaves of Cupania latifolia (Sapindaceae). The structure was determined to be (2E,6E,12E,16E)-3,7,13,17,21-pentamethyl-10-(1-methylethenyl)-2,6,12,16,20-docosapentaen-1-ol on the basis of spectral analysis and conversion to a known compound.
(キーワード): cupaniol / Cupania latifolia / Sapindaceae / branched polyprenol
(出版サイトへのリンク): ● Publication site (DOI): 10.1248/cpb.53.1037
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 16079544; ● Search Scopus @ Elsevier (PMID): 16079544; ● Search Scopus @ Elsevier (DOI): 10.1248/cpb.53.1037

(DOI: 10.1248/cpb.53.1037, PubMed: 16079544) Naonobu Tanaka, Mamoru Okasaka, Youko Ishimaru, Yoshihisa Takaishi, Mitsunobu Sato, Masato Okamoto, Tetsuya Oshikawa, Sharif Uddin Ahmed, L. Mark Consentino and Kuo-Hsiung Lee :
Biyouyanagin A, an Anti-HIV Agent from Hypericum chinense L. var. salicifolium,
Organic Letters, Vol.7, No.14, 2997-2999, 2005.

(要約): [structure: see text] A structurally unique hydrophobic compound, biyouyanagin A, was isolated from the MeOH extract of the leaves of Hypericum chinense L. var. salicifolium. The structure of biyouyanagin A was elucidated on the basis of spectroscopic evidence. Biyouyanagin A showed a significant activity against HIV and inhibited cytokine production.
(キーワード): Anti-HIV Agents / Cytokines / Hypericum / Interleukin-10 / Interleukin-12 / Lipopolysaccharides / Molecular Structure / Plant Leaves / Plants, Medicinal / Sesquiterpenes / Spiro Compounds / Tumor Necrosis Factor-alpha
(出版サイトへのリンク): ● Publication site (DOI): 10.1021/ol050960w
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15987189; ● Search Scopus @ Elsevier (PMID): 15987189; ● Search Scopus @ Elsevier (DOI): 10.1021/ol050960w

(DOI: 10.1021/ol050960w, PubMed: 15987189) Xiaodong Wang, Wenyuan Gao, Zhi Yao, Shaoyu Zhang, Yanwen Zhang, Yoshihisa Takaishi and Hongquan Duan :
Immunosuppressive Sesquiterpenes from Tripterygium wilfordii,
Chemical & Pharmaceutical Bulletin, Vol.53, No.6, 607-610, 2005.

(要約): Five new sesquiterpenes, 1beta-furanoyl-2beta,3alpha,7alpha,8beta,11-pentaacetoxy-4alpha,5alpha-dihydroxy-dihydroagarofuran (1), 1beta,2beta,3alpha,5alpha,7beta,8beta,11-heptaacetoxy-dihydroagarofuran (2), 1beta-furanoyl-2beta,3alpha,7alpha,8beta,11-pentaacetoxy-5alpha-hydroxy-dihydroagarofuran (3), 1beta,7beta,8alpha-triacetoxy-2beta-furanoyl-4alpha-hydroxy-11-isobutyryloxy-dihydroagarofuran (4), and 1beta-nicotinoyl-2beta,5alpha,7beta-triacetoxy-4alpha-hydroxy-11-isobutyryloxy-8alpha-furanoyl-dihydroagarofuran (5), were isolated from the xylem of Tripterygium wilfordii, together with a known compound (6). Their structures were elucidated on the basis of spectroscopic studies. Compounds 2-5 showed significant immunosuppressive activities.
(キーワード): Tripterygium wilfordii / xylem / sesquiterpene / immunosuppressive activity
(出版サイトへのリンク): ● Publication site (DOI): 10.1248/cpb.53.607
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15930767; ● Search Scopus @ Elsevier (PMID): 15930767; ● Search Scopus @ Elsevier (DOI): 10.1248/cpb.53.607

(DOI: 10.1248/cpb.53.607, PubMed: 15930767) Toshimasa Ochi, Hirofumi Shibata, Tomihiko Higuti, Ko-hei Kodama, Takenori Kusumi and Yoshihisa Takaishi :
Anti-Helicobacter pylori Compounds from Santalum album,
Journal of Natural Products, Vol.68, No.6, 819-824, 2005.

(要約): Six new sesquiterpenes, (Z)-2beta-hydroxy-14-hydro-beta-santalol (1), (Z)-2alpha-hydroxy-albumol (2), 2R-(Z)-campherene-2,13-diol (3), (Z)-campherene-2beta,13-diol (4), (Z)-7-hydroxynuciferol (5), and (Z)-1beta-hydroxy-2-hydrolanceol (6), together with five known compounds, (Z)-alpha-santalol (7), (Z)-beta-santalol (8), (Z)-lanceol (9), alpha-santaldiol (10), and beta-santaldiol (11), were isolated from Santalum album, by using bioassay-guided fractionation for Helicobacter pylori. The structures were determined by extensive NMR studies. The absolute configuration of compound 3 was determined by a modified Mosher method. The crude extracts as well as the isolated compounds showed antibacterial activity against H. pylori. Especially, compounds 7 and 8 have strong anti-H. pylori activities against a clarithromycin-resistant strain (TS281) as well as other strains.
(キーワード): Anti-Bacterial Agents / Clarithromycin / Drug Resistance, Bacterial / Helicobacter pylori / Japan / Microbial Sensitivity Tests / Molecular Structure / Nuclear Magnetic Resonance, Biomolecular / Plants, Medicinal / Santalum / Sesquiterpenes / Stereoisomerism
(出版サイトへのリンク): ● Publication site (DOI): 10.1021/np040188q
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15974602; ● Search Scopus @ Elsevier (PMID): 15974602; ● Search Scopus @ Elsevier (DOI): 10.1021/np040188q

(DOI: 10.1021/np040188q, PubMed: 15974602) Adriana Bonilla, Carmenza Duque, Cristina Garzón, Yoshihisa Takaishi, Kazutaka Yamaguchi, Noriyuki Hara and Yoshinori Fujimoto :
Champanones, yellow pigments from the seeds of champa (Campomanesia lineatifolia),
Phytochemistry, Vol.66, No.14, 1736-1740, 2005.

(要約): Chemical investigation of the methanol extract of the seeds of Campomanesia lineatifolia Ruiz and Pav. (Myrtaceae) led to the isolation of two new beta-triketone type compounds, named champanones A (1) and B (2), together with the known 2,3-dihydro-5-hydroxy-6,8,8-trimethyl-2-phenyl-4H-1-benzopyran-4,7(8H)-dione (champanone C) (3). The structures of 1 and 2 were determined to be 2,2,4,4-tetramethyl-6-(1-oxo-3-phenylprop-2-enyl) cyclohexane-1,3,5-trione (occurs as an enol form) and 2,2,4-trimethyl-6-(1-oxo-3-phenylprop-2-enyl)cyclohexane-1,3,5-trione (occurs as an enol form), respectively, by means of spectroscopic analysis. The three compounds showed mild antimicrobial activity.
(キーワード): Campomanesia lineatifolia / Myrtaceae / Champanone / Champa / β-Triketones / Pigments
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.phytochem.2005.05.025
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 16005915; ● Search Scopus @ Elsevier (PMID): 16005915; ● Search Scopus @ Elsevier (DOI): 10.1016/j.phytochem.2005.05.025

(DOI: 10.1016/j.phytochem.2005.05.025, PubMed: 16005915) Ai Suga, Yoshihisa Takaishi, Hiroyuki Nakagawa, Tadashi Iwasa, Mitsunobu Sato and Masato Okamoto :
Chemical Constituents from Fruits and Seeds of Myrica rubra (Myricaceae),
Natural Medicines, Vol.59, No.2, 70-75, 2005.

(要約): Two dammarane-type triterpenes and one steroid were isolated from the fruits of Myrica rubra and one furofran lignan was isolated from the seeds of M.rubra. Their structures were determined on the basis of spectral evidence. In addition, 16 known compounds were assayed for LPS-induced cytokine production.
(キーワード): Myrica rubra / Myricaceae / Dammarane / Furofran lignan / LPS-induced cytokine production
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1520572358490352768; ● Summary page in Scopus @ Elsevier: 2-s2.0-18344373888

(CiNii: 1520572358490352768, Elsevier: Scopus) Toshimasa Ochi, Yoshihisa Takaishi, Hirofumi Shibata, Higuti Tomihiko and Mai Kataoka :
Chemical Constituents of Capsicum annuum L var. angulosum, and Anti Helicobacter pylori Activity,
Natural Medicines, Vol.59, No.2, 76-84, 2005.

(要約): One new and 47 known compounds were isolated from the fruits and the stems of Capsicum annuum var. angulosum. The structures of the isolated new and known compounds were determined by extensive NMR studies and compared with a reference value of the spectral data. Furthermore, antibacterial activity against Helicobacter pylori of the isolated 41 compounds was measured.
(キーワード): Capsicum annuum var. angulosum / Helicobacter pylori / antibacterial activity
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1520853832137182336; ● Summary page in Scopus @ Elsevier: 2-s2.0-18244369991

(CiNii: 1520853832137182336, Elsevier: Scopus) Takaaki Sagawa, Yoshihisa Takaishi, Yoshinori Fujimoto, Carmenza Duque, Coralia Osorio, Freddy Ramos, Garzon Cristina, Mitsunobu Sato, Masato Okamoto, Tetsuya Oshikawa and Sharif Uddin Ahmed :
Cyclobutane Dimers from the Colombian Medicinal Plant Achyrocline bogotensis,
Journal of Natural Products, Vol.68, No.4, 502-505, 2005.

(要約): Five cyclobutane dimers, achyrodimers A-E (1-5), along with 11 known compounds were isolated from the methanol extract of the Colombian medicinal plant Achyrocline bogotensis. Their structures were elucidated by spectroscopy. Several of these compounds were screened for cytokine-inducing activity in human peripheral blood mononuclear cells.
(キーワード): Achyrocline / Colombia / Cyclobutanes / Cytokines / Humans / Molecular Structure / Nuclear Magnetic Resonance, Biomolecular / Plants, Medicinal
(出版サイトへのリンク): ● Publication site (DOI): 10.1021/np040187y
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15844937; ● Search Scopus @ Elsevier (PMID): 15844937; ● Search Scopus @ Elsevier (DOI): 10.1021/np040187y

(DOI: 10.1021/np040187y, PubMed: 15844937) Nozomi Komakine, Yoshihisa Takaishi, Gisho Honda, Michiho Ito, Yoshio Takeda, Olimjon K. Kodzhimatov and Ozodbek Ashurmetov :
Indole alkaloids from Rheum maximowiczii,
Natural Medicines, Vol.59, No.1, 45-48, 2005.

(要約): A new indol alkaloid along with 17 known compounds were isolated from the seeds of Rheum maximowiczii Losinsk (Polygonaceae). Its structure was elucidated from the 2D NMR and other spectral evidence. Several of these compounds were screened for cytokine-inducing activity on human peripheral blood mononuclear cells. The cytokine-inducing activity of some of the isolated compounds is also reported.
(キーワード): Rheum maximowiczii / Polygonaceae / indol alkaloids / cytokine
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1520853833571258240; ● Summary page in Scopus @ Elsevier: 2-s2.0-14944348599

(CiNii: 1520853833571258240, Elsevier: Scopus) Hirofumi Shibata, Kyoko Kondo, Ryo Katsuyama, Kazuyoshi Kawazoe, Youichi Sato, Kotaro Murakami, Yoshihisa Takaishi, Naokatu Arakaki and Tomihiko Higuti :
Alkyl Gallates, Intensifiers of ß-Lactam Susceptibility in Methicillin-Resistant Staphylococcus aureus,
Antimicrobial Agents and Chemotherapy, Vol.49, No.2, 549-555, 2005.

(要約): We found that ethyl gallate purified from a dried pod of tara (Caesalpinia spinosa) intensified beta-lactam susceptibility in methicillin-resistant and methicillin-sensitive strains of Staphylococcus aureus (MRSA and MSSA strains, respectively). This compound and several known alkyl gallates were tested with MRSA and MSSA strains to gain new insights into their structural functions in relation to antimicrobial and beta-lactam susceptibility-intensifying activities. The maximum activity of alkyl gallates against MRSA and MSSA strains occurred at 1-nonyl and 1-decyl gallate, with an MIC at which 90% of the isolates tested were inhibited of 15.6 microg/ml. At concentrations lower than the MIC, alkyl gallates synergistically elevated the susceptibility of MRSA and MSSA strains to beta-lactam antibiotics. Such a synergistic activity of the alkyl gallates appears to be specific for beta-lactam antibiotics, because no significant changes were observed in the MICs of other classes of antibiotics examined in this study. The length of the alkyl chain was also associated with the modifying activity of the alkyl gallates, and the optimum length was C5 to C6. The present work clearly demonstrates that the length of the alkyl chain has a key role in the elevation of susceptibility to beta-lactam antibiotics.
(キーワード): Anti-Bacterial Agents / Drug Synergism / Gallic Acid / Magnetic Resonance Spectroscopy / Methicillin Resistance / Microbial Sensitivity Tests / Plant Extracts / Plants, Medicinal / Spectrometry, Mass, Electrospray Ionization / Staphylococcus aureus / beta-Lactams
(出版サイトへのリンク): ● Publication site (DOI): 10.1128/AAC.49.2.549-555.2005
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15673731; ● Search Scopus @ Elsevier (PMID): 15673731; ● Search Scopus @ Elsevier (DOI): 10.1128/AAC.49.2.549-555.2005

(DOI: 10.1128/AAC.49.2.549-555.2005, PubMed: 15673731) Erdem Yesilada, Erdal Bedir, Çalış İhsan, Yoshihisa Takaishi and Yasukazu Ohmoto :
Effects of triterpene saponins from Astragalus species on in vitro cytokine release,
Journal of Ethnopharmacology, Vol.96, No.1-2, 71-77, 2005.

(要約): Roots of Astragalus species are used to treat leukemia and for wound healing in Turkish folk medicine. In order to evaluate this information, the effect of 13 cycloartane- and 1 oleanan-type triterpene saponins isolated from Turkish species (Astragalus brachypterus, Astragalus cephalotes, Astragalus microcephalus, and Astragalus trojanus), as well as methanol extracts from the roots of three Astragalus species (Astragalus cephalotes, Astragalus oleifolius and Astragalus trojanus) were studied. Cytokine concentrations of interleukins IL-1beta, IL-8 and TNF-alpha after bacterial lipopolysaccharide (LPS) and IL-2, IL-4 and INF-gamma after phorbolacetate (PHA) stimulation were determined using commercial enzyme-linked immunosorbent assay (ELISA) kits. All triterpene saponins tested in the present study showed a prominent IL-2 inducing activity between 35.9% and 139.6%. Among the extracts the highest score was obtained for Astragalus oleifolius (141.2%). Glycosides of 20,24-epoxy and 20,25-epoxy cycloartanes showed higher IL-2 inducing activity than those of acyclic-cycloartane derivatives as well as aglycone of 20,24-epoxy cycloartanes, cycloastrogenol. Especially the activity of Astragaloside VII, a tridesmosidic glycoside of cycloastrogenol, was the most remarkable. The oleanan-type triterpene saponin also showed a prominent IL-2 inducing activity. IL-2 is a cytokine produced by activated T cells, which has shown powerful immunostimulatory and antineoplastic properties. Accordingly, the IL-2 inducing activity of the triterpene saponins might be the mechanism involved in order to explain the immunomodulatory and anticancer effects of Astragalus species.
(キーワード): Astragalus spp. / Fabaceae / Cycloartane triterpene glycosides / Interleukin-2 / Interleukin-4 / Interleukin-1β / Interleukin-8 / Interferone-γ / Oleanan triterpene glycosides / Triterpene saponins / Tumor necrosis factor-α
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jep.2004.08.036
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15588652; ● Search Scopus @ Elsevier (PMID): 15588652; ● Search Scopus @ Elsevier (DOI): 10.1016/j.jep.2004.08.036

(DOI: 10.1016/j.jep.2004.08.036, PubMed: 15588652) Kentaro Kogure, Aiko Yamauchi, Akira Tokumura, Kyoko Kondou, Naonobu Tanaka, Yoshihisa Takaishi and Kenji Fukuzawa :
Novel antioxidants isolated from plants of the genera Ferula, Inula, Prangos and Rheum collected in Uzbekistan,
Phytomedicine, Vol.11, No.7-8, 645-651, 2004.

(要約): We examined the effects of 48 compounds isolated from Ferula pallida, F. penninervis, Inula macrophylla, Prangos pabularia, P. tschimganica and Rheum maximowiczii collected in Uzbekistan on ADP/Fe2+-induced lipid peroxidation of egg yolk phosphatidylcholine liposomes. Of those compounds, 23 inhibited ADP/Fe2+-induced lipid peroxidation and nine showed especially strong inhibition of lipid peroxidation. Most compounds that inhibited peroxidation scavenged the 1,1'-diphenyl-2-picrylhydrazyl (DPPH) radical, indicating that the inhibition was due to radical scavenging. However, some compounds did not scavenge DPPH but inhibited lipid peroxidation significantly, suggesting that their inhibitory effect was not due to radical scavenging but to some other mechanism, such as prevention of Fe2+ function. Thus, we found various new antioxidants, some of which had a unique mechanism of action, in Ferula, Inula, Prangos and Rheum plants collected in Uzbekistan as seeds used in medicine.
(キーワード): Antioxidants / Natural products / Ferula / Inula / Prangos / Rheum
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.phymed.2003.09.004
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15636179; ● Search Scopus @ Elsevier (PMID): 15636179; ● Search Scopus @ Elsevier (DOI): 10.1016/j.phymed.2003.09.004

(DOI: 10.1016/j.phymed.2003.09.004, PubMed: 15636179) Hiroyuki Nakagawa, Yoshihisa Takaishi, Yoshinori Fujimoto, Carmenza Duque, Cristina Garzon, Mitsunobu Sato, Masato Okamoto, Tetsuya Oshikawa and Sharif Uddin Ahmed :
Chemical Constituents from the Colombian Medicinal Plant Maytenus laevis,
Journal of Natural Products, Vol.67, No.11, 1919-1924, 2004.

(要約): The methanol extract of the bark of the Colombian medicinal plant Maytenus laevis gave six new compounds and 28 known compounds. The structures of the new and known compounds were elucidated on the basis of spectroscopic evidence. Several of these compounds were screened for cytokine-inducing activity on human PBMCs to investigate antitumor effects, and canophyllol (12) demonstrated the most effective induction of the cytokines.
(キーワード): Antineoplastic Agents, Phytogenic / Colombia / Cytokines / Drug Screening Assays, Antitumor / HLA Antigens / Humans / Leukocytes, Mononuclear / Maytenus / Molecular Structure / Nuclear Magnetic Resonance, Biomolecular / Plant Bark / Plants, Medicinal
(出版サイトへのリンク): ● Publication site (DOI): 10.1021/np040006s
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15568791; ● Search Scopus @ Elsevier (PMID): 15568791; ● Search Scopus @ Elsevier (DOI): 10.1021/np040006s

(DOI: 10.1021/np040006s, PubMed: 15568791) Yousuke Kawaguchi, Toshimasa Ochi, Yoshihisa Takaishi, Kazuyoshi Kawazoe and Kuo-Hsiung Lee :
New Sesquiterpenes from Capsicum annuum,
Journal of Natural Products, Vol.67, No.11, 1893-1896, 2004.

(要約): The ethyl acetate soluble fraction of a MeOH extract of the dried stems and roots of Capsicum annum gave 10 new sesquiterpenoids (1-10) and nine known compounds. The structures of the new compounds were elucidated on the basis of spectroscopic evidence. The isolated new compounds were evaluated for their cytotoxic activities.
(キーワード): Capsicum / Crystallography, X-Ray / HIV / Humans / Japan / Molecular Conformation / Molecular Structure / Nuclear Magnetic Resonance, Biomolecular / Plant Roots / Plant Stems / Plants, Medicinal / Sesquiterpenes / Tumor Cells, Cultured
(出版サイトへのリンク): ● Publication site (DOI): 10.1021/np0305472
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15568784; ● Search Scopus @ Elsevier (PMID): 15568784; ● Search Scopus @ Elsevier (DOI): 10.1021/np0305472

(DOI: 10.1021/np0305472, PubMed: 15568784) Naonobu Tanaka, Yoshihisa Takaishi, Yasuhiro Shikishima, Yuka Nakanishi, Kenneth Bastow, Kuo-Hsiung Lee, Gisho Honda, Michiho Ito, Yoshio Takeda, Olimjon K. Kodzhimatov and Ozodbek Ashurmetov :
Prenylated Benzophenones and Xanthones from Hypericum scabrum,
Journal of Natural Products, Vol.67, No.11, 1870-1875, 2004.

(要約): Two new polyprenylated benzophenones, a new polyprenylated phloroglucinol, and six new xanthone derivatives were isolated from the aerial parts of the Uzbekistan medicinal plant Hypericum scabrum. Their structures were elucidated on the basis of spectroscopic evidence. The isolated compounds showed moderate cytotoxicity for human tumor cells.
(キーワード): Antineoplastic Agents, Phytogenic / Benzophenones / Drug Screening Assays, Antitumor / Humans / Hypericum / Molecular Structure / Plants, Medicinal / Tumor Cells, Cultured / Uzbekistan / Xanthones
(出版サイトへのリンク): ● Publication site (DOI): 10.1021/np040024+
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15568778; ● Search Scopus @ Elsevier (PMID): 15568778; ● Search Scopus @ Elsevier (DOI): 10.1021/np040024+

(DOI: 10.1021/np040024+, PubMed: 15568778) Sayaka Nakano, Yoshinori Fujimoto, Yoshihisa Takaishi, Coralia Osorio and Carmenza Duque :
Cucurbita-5,23-diene-3β,25-diol from Sicana odorifera,
Fitoterapia, Vol.75, No.6, 609-611, 2004.

(要約): The spectral data of a new triterpene, cucurbita-5,23-diene-3beta,25-diol, isolated from the seeds of Sicana odorifera, are reported.
(キーワード): Cucurbitaceae / Humans / Magnetic Resonance Spectroscopy / Molecular Structure / Phytotherapy / Plant Extracts / Seeds
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.fitote.2004.05.004
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15351121; ● Search Scopus @ Elsevier (PMID): 15351121; ● Search Scopus @ Elsevier (DOI): 10.1016/j.fitote.2004.05.004

(DOI: 10.1016/j.fitote.2004.05.004, PubMed: 15351121) Naonobu Tanaka, Nobuyuki Ooba, Hongquan Duan, Yoshihisa Takaishi, Yuka Nakanishi, Kenneth Bastow and Kuo-Hsiung Lee :
Kaurane and abietane diterpenoids from Tripterygium doianum (Celastraceae),
Phytochemistry, Vol.65, No.14, 2071-2076, 2004.

(要約): Extraction of Tripterygium doianum (Celastraceae) afforded five new diterpenoids and 11 known diterpenoids belonging to the ent-kaurane and abietane families. Their structures were established based on spectroscopic studies. The isolated compounds showed moderate cytotoxicity against human tumor cell assays.
(キーワード): Tripterygium doianum / Celastraceae / Diterpenoid / ent-Kaurane / Abietane / Cytotoxicity
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.phytochem.2004.04.032
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15279974; ● Search Scopus @ Elsevier (PMID): 15279974; ● Search Scopus @ Elsevier (DOI): 10.1016/j.phytochem.2004.04.032

(DOI: 10.1016/j.phytochem.2004.04.032, PubMed: 15279974) Young-Hwan Moon, Jeong-Yong Cho, Jae-Hak Moon, Kazuyoshi Kawazoe, Yoshihisa Takaishi and Keun-Hyung Park :
Sugar Constituents from the Roots of Lithospermum erythrorhizon,
Natural Medicines, Vol.58, No.3, 117, 2004.

(キーワード): Lithospermum erythrorhizon / D-(-)-bomesitol / 1-kestose / nystose
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1542261570219409536; ● Summary page in Scopus @ Elsevier: 2-s2.0-3142590452

(CiNii: 1542261570219409536, Elsevier: Scopus) Mamoru Okasaka, Yoshihisa Takaishi, Kentaro Kogure, Kenji Fukuzawa, Hirofumi Shibata, Tomihiko Higuti, Gisho Honda, Michiho Ito, Olimjon K. Kodzhimatov and Ozodbek Ashurmetov :
New Stilbene Derivatives from Calligonum leucocladum,
Journal of Natural Products, Vol.67, No.6, 1044-1046, 2004.

(要約): Two new stilbene derivatives, (E)-resveratrol 3-(6' '-galloyl)-O-beta-D-glucopyranoside (1) and (E)-resveratrol 3-(4' '-acetyl)-O-beta-D-xylopyranoside (2), and five known stilbene derivatives (3-7) were isolated from the dried aerial parts of Calligonum leucocladum. Their structures were established on the basis of spectroscopic evidence. Compound 1 showed antioxidant activity and a restorative effect of the inhibition of oxacillin to oxacillin/methicillin-resistant Staphylococcus aureus.
(キーワード): Drug Resistance, Multiple / Glucosides / Methicillin Resistance / Molecular Structure / Oxacillin / Plants, Medicinal / Polygonaceae / Staphylococcus aureus / Stilbenes / Uzbekistan
(出版サイトへのリンク): ● Publication site (DOI): 10.1021/np0304823
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15217293; ● Search Scopus @ Elsevier (PMID): 15217293; ● Search Scopus @ Elsevier (DOI): 10.1021/np0304823

(DOI: 10.1021/np0304823, PubMed: 15217293) Sezik Ekrem, Erdem Yesilada, Hüsnitdin Shadidoyatov, Zeynullah Kulivey, Alim M. Nigmatullaev, Aripov N. Hamdulla, Yoshihisa Takaishi, Yoshio Takeda and Gisho Honda :
Folk medicine in Uzbekistan: I. Toshkent, Djizzax, and Samarqand provinces,
Journal of Ethnopharmacology, Vol.92, No.2-3, 197-207, 2004.

(要約): Uzbekistan is one of the Turcic republics in Central Asia where a desert continental climate mainly prevails in territories. Nevertheless, this expedition was carried out in the northeast and east higher lands, where flora is richer. The interviews were performed in seven villages of Toshkent and in neighboring provinces of Samarqand, Djizzax and at Urgut Bazaar of Samarqand. Altogether 177 folk remedies were recorded in the surveyed area. Among these folk remedies, 162 remedies were obtained from 79 different kinds of plant species that belong to 31 different families, whereas, 15 animal originated remedies that belong to 8 different animals are listed, which includes their vernacular and scientific names, indications and recipes for preparations.
(キーワード): Uzbekistan / Folk medicine / Toshkent / Samarqand / Djizzax
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jep.2004.02.016
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15138001; ● Search Scopus @ Elsevier (PMID): 15138001; ● Search Scopus @ Elsevier (DOI): 10.1016/j.jep.2004.02.016

(DOI: 10.1016/j.jep.2004.02.016, PubMed: 15138001) Wenyuan Gao, Rong Zhang, Wei Jia, Jun Zhang, Yoshihisa Takaishi and Hongquan Duan :
Immunosuppressive Diterpenes from Veronicastrum sibiricum,
Chemical & Pharmaceutical Bulletin, Vol.52, No.1, 136-137, 2004.

(要約): Two new diterpenes, named sibiriquinone A (1) and B (2), along with four known diterpenes have been isolated from the aerial part of Veronicastrum sibiricum. Their structures were elucidated by spectroscopy. The isolated compounds showed significant immunosuppressive activities.
(キーワード): Veronicastrum sibiricum / diterpene / immunosuppressive activity
(出版サイトへのリンク): ● Publication site (DOI): 10.1248/cpb.52.136
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 14709882; ● CiNii @ 国立情報学研究所 (CRID): 1390282679147970176; ● Search Scopus @ Elsevier (PMID): 14709882; ● Search Scopus @ Elsevier (DOI): 10.1248/cpb.52.136

(DOI: 10.1248/cpb.52.136, PubMed: 14709882, CiNii: 1390282679147970176) Ai Suga, Yoshihisa Takaishi, Satoru GOTO, Tatsuo Munakata, Izumi Yamauchi and Kentaro Kogure :
Two lignan dimers from bamboo stems (Phyllostachys edulis),
Phytochemistry, Vol.64, No.5, 991-996, 2003.

(要約): Phyllostadimers A and B, two bis-lignans in which the two lignan units are directly connected by a C-C bond, were isolated from stems of bamboo, Phyllostachys edulis. Their structures were determined on the basis of spectral evidence. In addition, 14 known compounds were also obtained throughout the investigation. Phyllostadimer A significantly inhibited liposomal lipid peroxidation.
(キーワード): Phyllostachys edulis / Gramineae / Lignan dimers / Antioxidant activity
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0031-9422(03)00422-9
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 14561516; ● Search Scopus @ Elsevier (PMID): 14561516; ● Search Scopus @ Elsevier (DOI): 10.1016/S0031-9422(03)00422-9

(DOI: 10.1016/S0031-9422(03)00422-9, PubMed: 14561516) Masahiro Nagase, Jinsei Oto, Sin Sugiyama, Kouichi Yube, Yoshihisa Takaishi and Nobuo Sakato :
Apoptosis Induction in HL-60 Cells and Inhibition of Topoisomerase II by Triterpene Celastrol,
Bioscience, Biotechnology, and Biochemistry, Vol.67, No.9, 1883-1887, 2003.

(要約): Celastrol, which is a triterpene purified from Celastraceae plants, has anticancer and anti-inflammatory activities. In this study we investigated to clarify whether celastrol can induce apoptosis in a human leukemia HL-60 model system. Celastrol was found to induce apoptosis, and the rank order of the potency of celastrol and its derivatives to induce internucleosomal DNA fragmentation was found to be celastrol>cela-H>the other derivatives=vehicle control. Many anticancer agents are known to possess the ability to inhibit topoisomerase II, so the inhibitory activities of celastrol and its derivatives on topoisomerase II were also explored. The rank order of the inhibitory activity was found to be celastrol>etoposide>cela-H, indicating that the apoptosis-inducing activities of cela derivatives correspond to their inhibitory activities on topoisomerase II. These data suggested that celastrol may cause its effects such as anticancer activity by the mechanism of apoptosis along with topoisomerase II inhibition.
(キーワード): Antineoplastic Agents, Phytogenic / Apoptosis / DNA Fragmentation / Dose-Response Relationship, Drug / Enzyme Inhibitors / Etoposide / Flow Cytometry / HL-60 Cells / Humans / Inhibitory Concentration 50 / Molecular Structure / Time Factors / Topoisomerase II Inhibitors / Triterpenes
(出版サイトへのリンク): ● Publication site (DOI): 10.1271/bbb.67.1883
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 14519971; ● Search Scopus @ Elsevier (PMID): 14519971; ● Search Scopus @ Elsevier (DOI): 10.1271/bbb.67.1883

(DOI: 10.1271/bbb.67.1883, PubMed: 14519971) Toshimasa Ochi, Yoshihisa Takaishi, Kentarou Kogure and Izumi Yamauti :
Antioxidant Activity of a New Capsaicin Derivative from Capsicum annuum,
Journal of Natural Products, Vol.66, No.8, 1094-1096, 2003.

(要約): A new capsaicin derivative, 6' ',7' '-dihydro-5',5' "-dicapsaicin (1), and a known capsaicin metabolite, omega-hydroxycapsaicin (2),(1) were isolated from the fruit of Capsicum annuum. Their structures were established on the basis of spectroscopic evidence. Compound 1 showed almost the same antioxidant activity as capsaicin, but did not have a pungent taste.
(キーワード): Antioxidants / Capsaicin / Capsicum / Fruit / Japan / Lipid Metabolism / Liposomes / Molecular Structure / Nuclear Magnetic Resonance, Biomolecular / Plants, Medicinal / Taste
(出版サイトへのリンク): ● Publication site (DOI): 10.1021/np020465y
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12932131; ● Search Scopus @ Elsevier (PMID): 12932131; ● Search Scopus @ Elsevier (DOI): 10.1021/np020465y

(DOI: 10.1021/np020465y, PubMed: 12932131) Kazuyoshi Kawazoe, Nao Morishita, Nagao Asako, Yoshihisa Takaishi, Gisho Honda, Mrchiho Ito, Yoshio Takeda, Olimjon K. Kodzhimatov and Ozodbek Ashurmetov :
Sesquiterpenoids from Artemisia tenuisecta,
Natural Medicines, Vol.57, No.3, 114-116, 2003.

(要約): From the aerial part of Artemisia tenuisecta Nevski (Asteraceae) a new sesquiterpene along with 16 known sesquiterpenoides were isolated. Its relative structure was elucidated as 1α-acetoxyeudesm- 4,5-expoxy-6β,11βH-12,6-olide from the 2D NMR and other spectral evidence.
(キーワード): Artemisia tenuisecta / Asteraceae / sesquiterpenoid / Uzbekistan
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1520572357193355008; ● Summary page in Scopus @ Elsevier: 2-s2.0-0037787823

(CiNii: 1520572357193355008, Elsevier: Scopus) 三谷裕昭, 高石喜久, 滝口祥令 :
中国製ダイエット食品により肝障害·甲状腺中毒症を示した症例,
日本医事新報, Vol.4122, 40-44, 2003年. Kazuyoshi Kawazoe, Yoshiko Tsubouchi, Norasyikin Abdullah, Yoshihisa Takaishi, Hirofumi Shibata, Tomihiko Higuti, Hitoshi Hori and Makoto Ogawa :
Sesquiterpenoids from Artemisia gilvescens and an Anti-MRSA Compound,
Journal of Natural Products, Vol.66, No.4, 538-539, 2003.

(要約): A new secoguaianolide sesquiterpene (1) was isolated along with its three stereoisomers (2-4) from the nonmedicinal plant Artemisia gilvescens. The structure of 1 was elucidated to be (4S,5S)-dihydro-5-[(1R,2S)-2-hydroxy-2-methyl-5-oxo-3-cyclopenten-1-yl]-3-methylene-4-(3-oxobutyl)-2(3H)-furanone on the basis of 2D NMR and other spectroscopic evidence. Five known sesquiterpenoids were also isolated from this plant, and one of them (5) showed activity against methicillin-resistant Staphylococcus aureus (MRSA).
(キーワード): Anti-Bacterial Agents / Artemisia / Furans / Japan / Methicillin Resistance / Microbial Sensitivity Tests / Molecular Structure / Nuclear Magnetic Resonance, Biomolecular / Sesquiterpenes / Staphylococcus aureus / Stereoisomerism
(出版サイトへのリンク): ● Publication site (DOI): 10.1021/np020593m
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12713410; ● Search Scopus @ Elsevier (PMID): 12713410; ● Search Scopus @ Elsevier (DOI): 10.1021/np020593m

(DOI: 10.1021/np020593m, PubMed: 12713410) Yasuhiro Shikishima, Yoshihisa Takaishi, Gisho Honda, Michiho Ito, Yoshio Takeda, Motoo Tori, Shigeru Takaoka, Olimjon K. Kodzhimatov and Ozodbek Ashurmetov :
Sesquiterpenes from Ferula penninervis,
Journal of Natural Products, Vol.65, No.12, 1897-1903, 2002.

(要約): The ethyl acetate soluble extract of the dried roots of Ferula penninervis gave 17 new sesquiterpenes [15 of the guaiane-type, ferupennins A-O (1-15), and two of the eudesmane-type, 1alpha-hydroxy-2-oxo-5alpha,7beta,11betaH-eudesm-3-en-6alpha,12-olide (16) and penninervin (17)] and nine known sesquiterpenes. The structures of the new compounds were elucidated on the basis of spectroscopic evidence and X-ray analysis. The absolute configuration of ferupennin A (1) was determined by a modified Mosher method.
(キーワード): Acetates / Acetylation / Adult / Crystallography, X-Ray / Enzyme-Linked Immunosorbent Assay / Ferula / Humans / Interleukin-1 / Interleukin-2 / Interleukin-4 / Lipopolysaccharides / Molecular Conformation / Molecular Structure / Nuclear Magnetic Resonance, Biomolecular / Plant Roots / Plants, Medicinal / Sesquiterpenes / Spectrophotometry, Ultraviolet / Tumor Necrosis Factor-alpha / Uzbekistan
(出版サイトへのリンク): ● Publication site (DOI): 10.1021/np020014d
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12502335; ● Search Scopus @ Elsevier (PMID): 12502335; ● Search Scopus @ Elsevier (DOI): 10.1021/np020014d

(DOI: 10.1021/np020014d, PubMed: 12502335) Hongquan Duan, Yoshihisa Takaishi, Motoo Tori, Shigeru Takaoka, Gisho Honda, Michiho Ito, Yoshio Takeda, Olimjon K. Kodzhimatov and Ozodebek A Ashurmetov :
Polysulfide Derivatives from Ferula foetida,
Journal of Natural Products, Vol.65, No.11, 1667-1669, 2002.

(要約): The ethyl acetate-soluble fraction from a methanol extract of Ferula foetida has afforded six new sulfide derivatives, (E)-3-methylsulfinyl-2-propenyl sec-butyl disulfide (foetisulfide A) (1), (Z)-3-methylsulfinyloxy-2-propenyl sec-butyl disulfide (foetisulfide B) (2), (E)-3-methylsulfinyloxy-2-propenyl sec-butyl disulfide (foetisulfide C) (3), bis(3-methylthio-2E-propenyl) disulfide (foetisulfide D) (4), 3,4,5-trimethyl-2-thiophenecarboxylic acid (foetithiophene A) (5), 3,4,5-trimethyl-2-(methylsulfinyloxymethyl)thiophene (foetithiophene B) (6), along with six known compounds. The structures of 1-6 were established on the basis of spectroscopic studies, with the elucidation of 5 confirmed by single-crystal X-ray crystallography.
(キーワード): Chromatography, High Pressure Liquid / Crystallography, X-Ray / Ferula / Medicine, Traditional / Molecular Conformation / Molecular Structure / Nuclear Magnetic Resonance, Biomolecular / Plant Roots / Plants, Medicinal / Stereoisomerism / Sulfides / Thiophenes / Uzbekistan
(出版サイトへのリンク): ● Publication site (DOI): 10.1021/np010541h
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12444696; ● Search Scopus @ Elsevier (PMID): 12444696; ● Search Scopus @ Elsevier (DOI): 10.1021/np010541h

(DOI: 10.1021/np010541h, PubMed: 12444696) Yoshio Takeda, Natsuko Isai, Toshiya Masuda, Hideaki Otsuka, Gisho Honda, Yoshihisa Takaishi, Fumiyuki Kiuchi, Michiho Ito, Ozodebek A Ashurmetov and Olimjon K Khodzhimatov :
A new megastigmane glucoside from Phlomis spinidens,
Natural Medicines, Vol.56, No.5, 200-203, 2002.

(要約): ウズベキスタン産しそ科植物Phlomis spinidensの微量成分を検索し，phlomisionosideと命名したメガスチグマン配糖体を単離し，その化学構造を明らかにした．
(キーワード): Phlomis spinidens / Labiatae / phlomisionoside / megastigmane glucoside
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1520290884137604096; ● Summary page in Scopus @ Elsevier: 2-s2.0-0036814788

(CiNii: 1520290884137604096, Elsevier: Scopus) Naonobu Tanaka, Hong-Quan Duan, Yoshihisa Takaishi, Kazuyoshi Kawazoe and Satoru GOTO :
Terpenoids from Tripterygium doianum (Celastraceae),
Phytochemistry, Vol.61, No.1, 93-98, 2002.

(要約): The extract of Tripterygium doianum (Celastraceae) afforded three triterpenoids [3beta-acetoxy-11-ursen-13alpha,30-olide, 25-chloro-24-hydroxytirucall-7-en-3-one and tirucall-7-en-3,24-dione], two sesquiterpenoids [5alpha-acetoxy-1beta,8alpha-bis-cinnamoyl-4alpha-hydroxydihydroagarofuran and 5alpha-acetoxy-1beta-benzoyl-8alpha-cinnamoyl-4alpha-hydroxydihydroagarofuran] and nine known triterpenoids. Their structures were established based on spectroscopic studies.
(キーワード): Tripterygium doianum / Celastraceae / Triterpenoid / Sesquiterpenoid
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0031-9422(02)00219-4
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12165306; ● Search Scopus @ Elsevier (PMID): 12165306; ● Search Scopus @ Elsevier (DOI): 10.1016/S0031-9422(02)00219-4

(DOI: 10.1016/S0031-9422(02)00219-4, PubMed: 12165306) Kimiko Tamemoto, Yoshihisa Takaishi, Kazuyoshi Kawazoe, Gisho Honda, Michiho Ito, Fumiyuki Kiuchi, Yoshio Takeda, Olimjon K. Kodzhimatov, Ozodbek Ashurmetov, Katsuhide Shimizu, Hideko Nagasawa, Yoshihiro Uto and Hitoshi Hori :
An Unusual Sesquiterpene Derivative from Ferula Kuhistanica,
Journal of Natural Products, Vol.65, No.9, 1323-1324, 2002.

(要約): Ferula Kuhistanicaより単離したセスキテルペン誘導体の構造決定と活性を明らかにした．
(キーワード): Anti-Bacterial Agents / Antineoplastic Agents, Phytogenic / Colonic Neoplasms / Drug Screening Assays, Antitumor / Ferula / Fruit / Humans / Inhibitory Concentration 50 / Methicillin / Molecular Conformation / Molecular Structure / Nuclear Magnetic Resonance, Biomolecular / Plants, Medicinal / Sesquiterpenes / Staphylococcus aureus / Tumor Cells, Cultured / Uzbekistan
(出版サイトへのリンク): ● Publication site (DOI): 10.1021/np020020+
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12350156; ● Search Scopus @ Elsevier (PMID): 12350156; ● Search Scopus @ Elsevier (DOI): 10.1021/np020020+

(DOI: 10.1021/np020020+, PubMed: 12350156) Kenji Okazaki, Kazuyoshi Kawazoe and Yoshihisa Takaishi :
Human platelet aggregation inhibitors from thyme (Thymus vulgaris L.),
Phytotherapy Research, Vol.16, No.4, 398-399, 2002.

(キーワード): thyme / antiplatelet activity / Thymus vulgaris L. / Labiatae
(出版サイトへのリンク): ● Publication site (DOI): 10.1002/ptr.979
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12112303; ● Search Scopus @ Elsevier (PMID): 12112303; ● Search Scopus @ Elsevier (DOI): 10.1002/ptr.979

(DOI: 10.1002/ptr.979, PubMed: 12112303) Yukiko Tada, Yasuhiro Shikishima, Yoshihisa Takaishi, Hirofumi Shibata, Tomihiko Higuti, Gisho Honda, Michiho Ito, Yoshio Takeda, Olimjon K. Kodzhimatov, Ozodbek Ashurmetov and Yasukazu Ohmoto :
Coumarins and γ-pyrone derivatives from Prangos pabularia: antibacterial activity and inhibition of cytokine release,
Phytochemistry, Vol.59, No.6, 649-654, 2002.

(キーワード): Prangos pabularia / Umbelliferae / Coumarins / γ-Pyrone derivatives / Antibacterial activity / Cytokine release
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0031-9422(02)00023-7
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11867097; ● CiNii @ 国立情報学研究所 (CRID): 1573950401491313792; ● Search Scopus @ Elsevier (PMID): 11867097; ● Search Scopus @ Elsevier (DOI): 10.1016/S0031-9422(02)00023-7

(DOI: 10.1016/S0031-9422(02)00023-7, PubMed: 11867097, CiNii: 1573950401491313792) Michiko Matsuhisa, Yasuhiro Shikishima, Yoshihisa Takaishi, Gisho Honda, Michiho Ito, Yoshio Takeda, Hirofumi Shibata, Tomihiko Higuti, Olimjon K. Kodzhimatov and Ozodbek Ashurmetov :
Benzoylphloroglucinol Derivatives from Hypericum scabrum,
Journal of Natural Products, Vol.65, No.3, 290-294, 2002.

(要約): Nine new polyprenylated benzoylphloroglucinol derivatives, hyperibones A-I (1-9), were isolated from the aerial parts of the Uzbekistan medicinal plant Hypericum scabrum. Their structures were determined mainly on the basis of spectroscopic evidence (2D NMR and HRMS). Compounds 1, 2, and 4 showed mild in vitro antibacterial activity against methicillin-resistance Staphylococus aureus (MRSA) and methicillin-sensitive Staphylococus aureus (MSSA).
(キーワード): Anti-Bacterial Agents / Chromatography, High Pressure Liquid / Drug Resistance, Microbial / Hypericum / Methicillin Resistance / Microbial Sensitivity Tests / Molecular Structure / Nuclear Magnetic Resonance, Biomolecular / Phloroglucinol / Plants, Medicinal / Spectroscopy, Fourier Transform Infrared / Staphylococcus aureus / Uzbekistan
(出版サイトへのリンク): ● Publication site (DOI): 10.1021/np010310a
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11908967; ● Search Scopus @ Elsevier (PMID): 11908967; ● Search Scopus @ Elsevier (DOI): 10.1021/np010310a

(DOI: 10.1021/np010310a, PubMed: 11908967) Hongquan Duan, Yoshihisa Takaishi, Yoshinori Fujimoto, Cristina Garzon, Coralia Osorio and Carmenza Duque :
Chemical Constituents from the Colombian Medicinal Plant Niphogeton ternata,
Chemical & Pharmaceutical Bulletin, Vol.50, No.1, 115-117, 2002.

(要約): Two coumarins and one polyacetylene, 5-O-(3-chloro-2-hydroxy-3-methylbutyl)-8-methoxypsoralen(1), 2', 3'-dihydro-jatamansin(2), and 10-chloro-1-heptadecene-4, 6-diyne-3, 8, 9-triol(3), along with 15 known compounds(4-18), were isolated from the methanol extract of Niphogeton ternata. Their structures were elucidated by spectroscopy.
(キーワード): Niphogeton ternata / Umbelliferae / coumarin / polyacetylene
(出版サイトへのリンク): ● Publication site (DOI): 10.1248/cpb.50.115
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11824570; ● CiNii @ 国立情報学研究所 (CRID): 1390282679141387008; ● Search Scopus @ Elsevier (PMID): 11824570; ● Search Scopus @ Elsevier (DOI): 10.1248/cpb.50.115

(DOI: 10.1248/cpb.50.115, PubMed: 11824570, CiNii: 1390282679141387008) Hongquan Duan, Yoshihisa Takaishi, Hiroshi Momota, Yasukazu Ohmoto and Takao Taki :
Immunosuppressive constituents from Saussurea medusa,
Phytochemistry, Vol.59, No.1, 85-90, 2002.

(要約): The methanol extract of Saussurea medusa Maxim afforded two lignans: 2alpha-guaicyl-4-oxo-6alpha-catechyl-3,7-dioxabicyclo [3.3.0]octane and 1alpha-hydroxy-2alpha,4alpha-guaicyl-3,7-dioxabicyclo[3.3.0]octane; two chlorophyll derivatives: 13-epi-phaeophorbide-a and 13-epi-phaeophorbide-a methyl ester; one megastigmane derivative: 3beta-hydroxy-5alpha,6alpha-epoxy-7-megastigmen-9-one, along with 19 known compounds. Their structures were established on the basis of spectroscopic studies.
(キーワード): Saussurea medusa / Compositae / Lignan / Phaeophorbide / Immunosuppressive activity
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0031-9422(01)00429-0
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11754949; ● Summary page in Scopus @ Elsevier: 2-s2.0-0037116408

(DOI: 10.1016/S0031-9422(01)00429-0, PubMed: 11754949, Elsevier: Scopus) 金磯泰雄, 菅愛, 高石喜久 :
竹酢液によるイチゴおよびキュウリの数種病害に対する防除効果,
農業研究所試験研究報告, Vol.37, No.37, 37-42, 2002年.

(要約): 竹酢液をイチゴおよぴキュウリに散布し，数種病害に対する発病抑制効果を検討した．イチゴでは，うどんこ病に対する10倍液散布で防除効果が若干認められたが，葉先や葉裏が局部的に黒変する薬害が発生した．炭疽病，輪斑病に対する50倍液の散布効果はほとんど認められなかった．キュウリではうどんこ病に対する50倍液散布で防除効果が明瞭に認められたが，べと病に対する効果は低かった．また炭疽病，褐斑病に対する効果は全く認められなかった．
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1050564288620654208

(CiNii: 1050564288620654208) D. Deliorman, E. Yesilada, F. Ergun, Y. Tsuchiya and Yoshihisa Takaishi :
The antioxidant activity of the extracts and fractions from Carduus nutans L.,
Gazi Universitesi Eczacilik Fakultesi Dergisi, Vol.19, No.1, 61-66, 2002. Bo Fu, Bao-Ning Su, Yoshihisa Takaishi, Gisho Honda, Michiho Ito, Yoshio Takeda, Olimjon K. Kodzhimatov and Ozodbek Ashurmetov :
A bis-sesquiterpene and sesquiterpenolides from Inula macrophylla,
Phytochemistry, Vol.58, No.7, 1121-1128, 2001.

(要約): Macrophyllidimer C, a novel bis-sesquiterpene, in which the two sesquiterpene units are directly connected by a C-C bond, and eight other sesquiterpenolides were obtained from the bark of Inula macrophylla. Seven of these, macrophyllilactones A-G, are new eudesmanolide- and elemanolide-type sesquiterpenes. Their structures were determined on the basis of spectroscopic evidence and chemical reaction.
(キーワード): Inula macrophylla / Compositae / Macrophyllidimer C / bis-Sesquiterpene / Macrophyllilactones A G / Eudesmanolide and elemanolide sesquiterpenes
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0031-9422(01)00334-X
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11730877; ● Summary page in Scopus @ Elsevier: 2-s2.0-0035818769

(DOI: 10.1016/S0031-9422(01)00334-X, PubMed: 11730877, Elsevier: Scopus) Kimiko Tamemoto, Yoshihisa Takaishi, Bei Chen, Kazuyoshi Kawazoe, Hirofumi Shibata, Tomihiko Higuti, Gisho Honda, Michiho Ito, Yoshio Takeda, Olimjon K. Kodzhimatov and Ozodbek Ashurmetov :
Sesquiterpenoids from the fruits of Ferula kuhistanica and antibacterial activity of the constituents of F. kuhistanica,
Phytochemistry, Vol.58, No.5, 763-767, 2001.

(要約): Ethyl acetate extracts of the air-dried fruits of Ferula kuhistanica afforded three daucane esters: kuhistanicaol H, I and J, together with nine other known compounds. Their structures were established on the basis of spectroscopic evidence. Isolated compounds in this paper and previously reported compounds from the roots and stems of F. kuhistanica were tested for antibacterial activity. Some of them were selectively toxic against Gram-positive bacteria, including methicillin-sensitive and methicillin-resistant Staphylococcus aureus (MSSA and MRSA).
(キーワード): Ferula kuhistanica / Umbelliferae / Sesquiterpenes / Daucane esters / Kuhistanicaol H, I, J / Antibacterial activity / MSSA / MRSA
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0031-9422(01)00307-7
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11672742; ● Summary page in Scopus @ Elsevier: 2-s2.0-0035900473

(DOI: 10.1016/S0031-9422(01)00307-7, PubMed: 11672742, Elsevier: Scopus) Hongquan Duan, Yoshihisa Takaishi, Hiroshi Momota, Yasukazu Ohmoto, Takao Taki, Motoo Tori, Shigeru Takaoka, Yongfeng Jia and Duan Li :
Immunosuppressive terpenoids from extracts of Tripterygium wilfordii,
Tetrahedron, Vol.57, No.40, 8413-8424, 2001.

(キーワード): Tripterygium wilfordii / Celastraceae / triterpenes / diterpenes / immunosuppressive activity / triptolide
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0040-4020(01)00724-4
(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-0035478094

(DOI: 10.1016/S0040-4020(01)00724-4, Elsevier: Scopus) Yoshio Takeda, Natsuko Isai, Toshiya Masuda, Gisho Honda, Yoshihisa Takaishi, Michiho Ito, Hideaki Otsuka, Ozodebek A Ashurmetov and Olimjon K Khodzhimatov :
Phlomisflavosides A and B, new flavonol diglycosides from Phlomis spinidens,
Chemical & Pharmaceutical Bulletin, Vol.49, No.8, 1039-1041, 2001.

(要約): ウズベキスタン産シソ科植物Phlomis spinidensの配糖体成分を検索し，新フラボノールdiglycosides,phlomisflavosides A, Bを単離し，その化学構造を明らかにした．

Yasuhiro Shikishima, Yoshihisa Takaishi, Gisho Honda, Michiho Ito, Yoshio Takeda, Olimjon K. Kodzhimatov, Ozodbek Ashurmetov and Kuo-Hsing Lee :
Chemical Constituents of Prangos tschimganica; Structure Elucidation and Absolute Configuration of Coumarin and Furanocoumarin Derivatives with Anti-HIV Activity,
Chemical & Pharmaceutical Bulletin, Vol.49, No.7, 877-880, 2001.

(要約): The methanol extract of the dried aerial parts of Prangos tschimganica gave three new coumarin derivatives and 30 known coumarin derivatives. Their structures were established on the basis of chemical and spectroscopic evidence. Absolute configuration of the isolated compounds were determined by using a modified Mosher's method. Some of the isolated compounds showed anti-HIV activity.
(キーワード): rangos tschimganica / Umbelliferae / coumarin derivative / anti-human immunodeficiency virus(HIV) activity / optical purity
(出版サイトへのリンク): ● Publication site (DOI): 10.1248/cpb.49.877
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11456095; ● CiNii @ 国立情報学研究所 (CRID): 1390001204160938368; ● Summary page in Scopus @ Elsevier: 2-s2.0-0034935950

(DOI: 10.1248/cpb.49.877, PubMed: 11456095, CiNii: 1390001204160938368, Elsevier: Scopus) Bei Chen, Yoshihisa Takaishi, Kazuyoshi Kawazoe, Kimiko Tamemoto, Gisho Honda, Michiho Ito, Yoshio Takeda, Olimjon K. Kodzhimatov and Ozodbek Ashurmetov :
Farnesyl Hydroxybenzoic Acid Derivatives from Ferula kuhistanica,
Chemical & Pharmaceutical Bulletin, Vol.49, No.6, 707-710, 2001.

(要約): Four new farnesyl hydroxybenzoic acid derivatives, kuhistanols E-H(1-4), were isolated from the roots of the Uzbekistan medicinal plant Ferula kuhistanica. The structures of the new compounds were elucidated based on spectroscopic and chemical evidence.
(キーワード): Ferula kuhistanica / Umbelliferae / prenylated benzoic acid / kuhistanols E-H
(出版サイトへのリンク): ● Publication site (DOI): 10.1248/cpb.49.707
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11411521; ● CiNii @ 国立情報学研究所 (CRID): 1390001204164185472; ● Summary page in Scopus @ Elsevier: 2-s2.0-0034954317

(DOI: 10.1248/cpb.49.707, PubMed: 11411521, CiNii: 1390001204164185472, Elsevier: Scopus) Yoshio Takeda, Satomi Tateoka, Toshiya Masuda, Hideaki Otsuka, Gisho Honda, Yoshihisa Takaishi, Michiho Ito, Olimjon K. Khodzhimatov and Ozodbek A. Ashurmetov :
A new neoclerodane diterpenoid from Scutellaria hematochlora,
Heterocycles, Vol.55, No.6, 1141-1145, 2001.

(要約): ウズベキスタン産シソ科植物Scutellaria hematochloraからneoclerodan型新ジテルペンを単離しその化学構造を明らかにした．
(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-0035365031

(Elsevier: Scopus) Hiroyuki Nakagawa, Hongquan Duan and Yoshihisa Takaishi :
Limonoids from Citrus sudachi,
Chemical & Pharmaceutical Bulletin, Vol.49, No.5, 649-651, 2001.

(要約): Four new limonoid derivatives, 1-O-methylichangensin(1), sudachinoid A(2), B(3), and C(4)were isolated from the seeds of Citrus sudachi, together with the known compounds ichangensin, obacunone, obacunoic acid and limonin, and the structures of the new compounds were elucidated based on spectroscopic and chemical evidence.
(キーワード): Citrus sudachi / Rutaceae / limonoid / sudachinoid
(出版サイトへのリンク): ● Publication site (DOI): 10.1248/cpb.49.649
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11383626; ● CiNii @ 国立情報学研究所 (CRID): 1390001204160862976; ● Summary page in Scopus @ Elsevier: 2-s2.0-0034992712

(DOI: 10.1248/cpb.49.649, PubMed: 11383626, CiNii: 1390001204160862976, Elsevier: Scopus) Bao-Ning Su, Yoshihisa Takaishi, Tetsuya Yabuuchi, Takenori Kusumi, Motoo Tori, Shigeru Takaoka, Gisho Honda, Michiho Ito, Yoshio Takeda, Olimjon K. Kodzhimatov and Ozodbek Ashurmetov :
Sesquiterpenes and Monoterpenes from the Bark of Inula macrophylla,
Journal of Natural Products, Vol.64, No.4, 466-471, 2001.

(要約): Eleven new sesquiterpenes (1--11) and two thymol derivatives (12, 13), along with 12 known sesquiterpenes and monoterpenes, were isolated from the bark of Inula macrophylla. Their structures were determined on the basis of spectral evidence (especially by HREIMS and 2D NMR) as well as chemical transformations. The structure of macrophyllic acid A (1) was confirmed by X-ray analysis, and the absolute configuration of 1 was determined on the basis of the appropriate chemical conversions and the application of a modified Mosher's method.
(キーワード): Crystallography, X-Ray / Inula / Models, Molecular / Molecular Structure / Sesquiterpenes / Spectrum Analysis / Terpenes
(出版サイトへのリンク): ● Publication site (DOI): 10.1021/np000211h
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11325229; ● Search Scopus @ Elsevier (PMID): 11325229; ● Search Scopus @ Elsevier (DOI): 10.1021/np000211h

(DOI: 10.1021/np000211h, PubMed: 11325229) Erdem Yesilada, Hitomi Taninaka, Yoshihisa Takaishi, Gisho Honda, Ekrem Sezik, Hiroshi Momota, Yasukazu Ohmoto and Takao Taki :
IN VITRO INHIBITORY EFFECTS OF DAPHNE OLEOIDES SSP. OLEOIDES ON INFLAMMATORY CYTOKINES AND ACTIVITY-GUIDED ISOLATION OF ACTIVE CONSTITUENTS,
Cytokine, Vol.13, No.6, 359-364, 2001.

(キーワード): Daphne oleoides spp. oleoides / diterpenoids / lignans / interleukin 1 inhibition / tumor necrosis factor
(出版サイトへのリンク): ● Publication site (DOI): 10.1006/cyto.2001.0838
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1006/cyto.2001.0838

(DOI: 10.1006/cyto.2001.0838) Yasuhiro Shikishima, Yoshihisa Takaishi, Gisho Honda, Michiho Ito, Yoshio Takeda, Olimjon K. Kodzhimatov and Ozodbek Ashurmetov :
Terpenoids and γ-pyrone derivatives from Prangos tschimganica,
Phytochemistry, Vol.57, No.1, 135-141, 2001.

(要約): The methanol extract of the dried aerial parts of Prangos tschimganica afforded seven monoterpenoids and four gamma-pyrone derivatives. Their structures were established on the basis of chemical and spectroscopic evidence.
(キーワード): Prangos tschimganica / Umbelliferae / Monoterpenoids / γ-Pyrone derivatives
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0031-9422(00)00407-6
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11336255; ● Summary page in Scopus @ Elsevier: 2-s2.0-0035341748

(DOI: 10.1016/S0031-9422(00)00407-6, PubMed: 11336255, Elsevier: Scopus) Hong-Quan Duan, Yoshihisa Takaishi, Yong-Feng Jia and Duan Li :
Sesquiterpene polyol esters from Tripterygium wilfordii,
Phytochemistry, Vol.56, No.4, 341-346, 2001.

(要約): The extract (T(II)) of Tripterygium wilfordii Hook f. afforded four sesquiterpene esters: 1beta,2beta,5alpha,8beta,11-pentaacetoxy-4alpha-hydroxy-3alpha(2'-methylbutanoyl)-15-nicotinoyl-7-oxo-dihydroagarofuran; 1beta,5alpha,11-triacetoxy-7beta-benzoyl-4alpha-hydroxy-8beta-nicotinoyl-dihydroagarofuran; 1beta,2beta,5alpha,11-tetraacetoxy-8alpha-benzoyl-4alpha-hydroxy-7beta-nicotinoyl-dihydroagarofuran; 5alpha-benzoyl-4alpha-hydroxy-1beta,8alpha-dinicotinoyl-dihydro- agarofuran as well as one other known sesquiterpene ester. Their structures were established on the basis of spectroscopic studies.
(キーワード): Tripterygium wilfordii / Celastraceae / TII / Sesquiterpene esters
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0031-9422(00)00369-1
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11249098; ● Search Scopus @ Elsevier (PMID): 11249098; ● Search Scopus @ Elsevier (DOI): 10.1016/S0031-9422(00)00369-1

(DOI: 10.1016/S0031-9422(00)00369-1, PubMed: 11249098) Shikishima Yasuhiro, Yoshihisa Takaishi, Gisho Honda, Michiho Ito, Yoshio Takeda, Olimjon K. Kodzhimatov and Ozodbek Ashurmetov :
Phenylbutanoids and stilbene derivatives of Rheum maximowiczii,
Phytochemistry, Vol.56, No.4, 377-381, 2001.

(要約): The methanol extract of the dried roots of Rheum maximowiczii afforded four phenylbutanoid and two stilbene derivatives. Their structures were established on the basis of chemical and spectroscopic studies.
(キーワード): Rheum maximowiczii / Polygonaceae / Phenylbutanoid / Stilbene dimer
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0031-9422(00)00370-8
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11249105; ● Summary page in Scopus @ Elsevier: 2-s2.0-0035961540

(DOI: 10.1016/S0031-9422(00)00370-8, PubMed: 11249105, Elsevier: Scopus) Ekrem Sezik, Erdem Yesilada, Gisho Honda, Yoshihisa Takaishi, Yoshio Takeda and Toshihiro Tanaka :
Traditional medicine in Turkey X. Folk medicine in Central Anatolia,
Journal of Ethnopharmacology, Vol.75, No.2-3, 95-115, 2001.

(要約): トルコ共和国中央Anatolia地方の伝統薬について現地調査し，その起源植物名，伝統的な用法などについて報告した．
(キーワード): Traditional medicine / Turkey / Central Anatolia
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0378-8741(00)00399-8
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11297840; ● Summary page in Scopus @ Elsevier: 2-s2.0-0035048443

(DOI: 10.1016/S0378-8741(00)00399-8, PubMed: 11297840, Elsevier: Scopus) Hongquan Duan, Yoshihisa Takaishi, Hiroshi Momota, Yasukazu Ohmoto, Takao Taki, Yongfeng Jia and Duan Li :
Immunosuppressive Sesquiterpene Alkaloids from Tripterygium wilfordii,
Journal of Natural Products, Vol.64, No.5, 582-587, 2001.

(要約): Nine new sesquiterpene pyridine alkaloids [wilfornines A (1), B (2), C (3), D (4), E (5), F (8), and G (9); wilfordinines I (6) and J (7)] and six known compounds (10-15) were isolated from a clinically used extract (T(II)) of Tripterygium wilfordii. The structures of 1-9 were elucidated by spectroscopic and chemical methods. The inhibitory effects on cytokine production of 1-3 and several related compounds were evaluated. Compounds 10 and 14 showed significant inhibitory effects on cytokine production.
(キーワード): Alkaloids / Anti-Inflammatory Agents / China / Cytokines / Humans / Immunosuppressive Agents / Magnetic Resonance Spectroscopy / Monocytes / Plants, Medicinal / Prednisolone / Sesquiterpenes / Spectrometry, Mass, Fast Atom Bombardment / Spectrophotometry, Infrared
(出版サイトへのリンク): ● Publication site (DOI): 10.1021/np000504a
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11374948; ● Search Scopus @ Elsevier (PMID): 11374948; ● Search Scopus @ Elsevier (DOI): 10.1021/np000504a

(DOI: 10.1021/np000504a, PubMed: 11374948) Kazuyoshi Kawazoe, Aki Yutani, Kimiko Tamemoto, Shuko Yuasa, Hirofumi Shibata, Tomihiko Higuti and Yoshihisa Takaishi :
Phenylnaphthalene Compounds from the Subterranean Part of Vitex rotundifolia and Their Antibacterial Activity Against Methicillin-Resistant Staphylococcus aureus,
Journal of Natural Products, Vol.64, No.5, 588-591, 2001.

(要約): A careful investigation of the subterranean part of Vitex rotundifolia has shown that this plant contains five novel lignans having a 1-phenylnaphthalene-type skeleton together with four known lignans. These structures were elucidated on the basis of spectroscopic data. Furthermore, some of the isolated compounds showed antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA).
(キーワード): Anti-Bacterial Agents / Asia / Mass Spectrometry / Methicillin Resistance / Microbial Sensitivity Tests / Naphthalenes / Plant Roots / Plants, Medicinal / Spectrophotometry, Infrared / Spectrophotometry, Ultraviolet / Staphylococcus aureus
(出版サイトへのリンク): ● Publication site (DOI): 10.1021/np000307b
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11374949; ● Search Scopus @ Elsevier (PMID): 11374949; ● Search Scopus @ Elsevier (DOI): 10.1021/np000307b

(DOI: 10.1021/np000307b, PubMed: 11374949) Erdem Yesilada, Koichiro Tsuchiya, Yoshihisa Takaishi and Kazuyoshi Kawazoe :
Isolation and characterization of free radical scavenging flavonoid glycosides from the flowers of Spartium junceum by activity-guided fractionation,
Journal of Ethnopharmacology, Vol.73, No.3, 471-478, 2000.

(要約): Spartium junceum L. (Fabaceae) flowers are used for the treatment of peptic ulcers in Turkish folk medicine. The possible superoxide dismutase-like activity of the extracts, fractions and constituents obtained through activity-guided fractionation were studied by using in vitro electron spin resonance spectrometry, in order to explain the role of antioxidant principles in the potent antiulcerogenic activity of the extract. Despite the fact that the triterpene, spartitrioside, which was previously reported as the active antiulcerogenic constituent of the flowers was found almost inactive, the flavonoid-rich fractions showed potent antioxidant activity. Five flavonoid glycosides bearing catechol structure in ring B were isolated from the butanol extract and their structures were elucidated using 1H- and 13C-NMR techniques as isoquercitrin (quercetin 3beta-glucoside) (1,); luteolin 4'beta-glucoside (2); quercetin 3, 4'-diglucoside (3); azaleatin 3beta-glucoside (quercetin 5-methylether 3beta-glucoside) (4), quercetin 4'beta-glucoside (5). Flavonoids (2) and (4) showed the highest in vitro antioxidant activity with 22.59 and 19.08 U/ml, respectively.
(キーワード): Electron spin resonance / Spartium junceum / Antioxidant activity / Superoxide dismutase-like activity / Spin trapping / Superoxide radical
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0378-8741(00)00327-5
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11091001; ● Search Scopus @ Elsevier (PMID): 11091001; ● Search Scopus @ Elsevier (DOI): 10.1016/S0378-8741(00)00327-5

(DOI: 10.1016/S0378-8741(00)00327-5, PubMed: 11091001) Bei Chen, Rie Teranishi, Kazuyoshi Kawazoe, Yoshihisa Takaishi, Gisho Honda, Michiho Itoh, Michiho Itoh, Yoshio Takeda and Olimjon K. Kodzhimatov :
Sesquiterpenoids from Ferula kuhistanica,
Phytochemistry, Vol.54, No.7, 717-722, 2000.

(要約): Methanol extracts of the air-dried roots and stems of Ferula kuhistanica afforded seven daucane-type sesquiterpenes, called kuhistanicaol A-G, together with 13 known daucane esters. Their structures were established on the basis of spectroscopic evidence and the results of chemical reactions.
(キーワード): Ferula kuhistanica / Umbelliferae / Sesquiterpenes / Daucane esters / Kuhistanicaol A G
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0031-9422(00)00197-7
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10975507; ● Search Scopus @ Elsevier (PMID): 10975507; ● Search Scopus @ Elsevier (DOI): 10.1016/S0031-9422(00)00197-7

(DOI: 10.1016/S0031-9422(00)00197-7, PubMed: 10975507) Yoshio Takeda, Kazumi Yanagihara, Toshiya Masuda, Hideaki Otsuka, Gisho Honda, Yoshihisa Takaishi, Ekrem Sezik and Erdem Yesilada :
Labdane diterpenoids from Marrubium globosum ssp. globosum,
Chemical & Pharmaceutical Bulletin, Vol.48, No.8, 1234-1235, 2000.

(要約): トルコ産薬用植物Marrubium globosum ssp. globosumのジテルペン成分について検索し，labdane 骨格を有する新微量成分を単離しその化学構造を明らかにした．

Erdem Yesilada, Yoshihisa Takaishi, Tetsuro Fujita and Ekrem Sezik :
Anti-ulcerogenic effects of Spartium junceum flowers on in vivo test models in rats,
Journal of Ethnopharmacology, Vol.70, No.3, 219-226, 2000.

(要約): Flowers of Spartium junceum L. (Fabaceae) are used for the treatment of gastric ulcers in Turkish folk medicine. Through bioassay-guided fractionation using chemical and chromatographical means and water immersion and restraint-induced stress ulcer model in rats, a saponin fraction was determined as the potent anti-ulcerogenic ingredient. The active fraction was also highly effective in preventing ethanol- and pyloric ligation-induced gastric lesions as well as inhibiting gastric secretion volume, gastric pH and titratable acidity, but did not affect the hexosamine content of the gastric mucosa. A novel oleanen-type triterpenic saponin, named as spartitrioside, was isolated as the active principle by using chromatographical separation techniques.
(キーワード): Spartium junceum L. / Fabaceae / Anti-ulcerogenic activity / Water-immersion and restraint-induced stress ulcer / Ethanol-induced ulcer / Pyloric ligation-induced ulcer / Gastric secretion / Hexosamine level / Oleanene-type saponin / Spartitrioside
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0378-8741(99)00180-4
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10837986; ● Summary page in Scopus @ Elsevier: 2-s2.0-0343183288

(DOI: 10.1016/S0378-8741(99)00180-4, PubMed: 10837986, Elsevier: Scopus) Hongquan Duan, Yoshihisa Takaishi, Hiroshi Momota, Yasukazu Ohmoto, Takao Taki, Yongfeng Jia and Duan Li :
Triterpenoids from Tripterygium wilfordii,
Phytochemistry, Vol.53, No.7, 805-810, 2000.

(要約): The extract (T(II)) of Tripterygium wilfordii Hook f. afforded four triterpenoids: wilforic acid D (3beta,24-epoxy-2alpha-hydroxy-24R*-ethoxy-29-friedelanoic acid); (E) 3beta,24-epoxy-2-oxo-3alpha-hydroxy-29-friedelanoic acid; (F) 2beta-hydroxy-3-oxo-friedelan-29-oic acid; 29-hydroxy-3-oxo-olean-12-en-28-oic acid and 17 known triterpenoids. Their structures were established on the basis of spectroscopic studies. In a bioactivity analysis, only the known dulcioic acid compound showed a significant inhibitory effect on cytokine production.
(キーワード): Tripterygium wilfordii / Triterpenoids / Immunosuppressive activity
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0031-9422(00)00007-8
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10783986; ● Summary page in Scopus @ Elsevier: 2-s2.0-0034616323

(DOI: 10.1016/S0031-9422(00)00007-8, PubMed: 10783986, Elsevier: Scopus) Bao-Ning Su, Yoshihisa Takaishi, Tetsuya Yabuuchi, Takenori Kusumi, Motoo Tori and Shigeru Takaoka :
The structures and absolute configurations of macrophyllic acids A E, five new rearranged eudesmane sesquiterpene acids from the bark of Inula macrophylla,
Tetrahedron Letters, Vol.41, No.14, 2395-2400, 2000.

(キーワード): Inula macrophylla / compositae / macrophyllic acids A E / sesquiterpene acid / new carbon skeleton / NMR data / chemical transformation / X-ray analysis / absolute configuration / biosynthetic pathway
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0040-4039(00)00172-6
(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-0034175575

(DOI: 10.1016/S0040-4039(00)00172-6, Elsevier: Scopus) Bao-Ning Su, Yoshihisa Takaishi, Gisho Honda, Michiho Itoh, Yoshio Takeda, Olimjon K. Kodzhimatov and Ozodbek Ashurmetov :
Sesquiterpene Phenylpropanoid and Sesquiterpene Chromone Derivatives from Ferula pallida,
Journal of Natural Products, Vol.63, No.4, 520-522, 2000.

(要約): Four novel compounds-two sesquiterpene phenylpropanoid derivatives, pallidones G (1) and H (2), and two sesquiterpene chromone derivatives, pallidones I (3) and J (4)-have been isolated from the roots of Ferula pallida. Their structures were determined on the basis of NMR and HREIMS evidence.
(キーワード): 4-Butyrolactone / Chromones / Ferula / Magnetic Resonance Spectroscopy / Mass Spectrometry / Plant Extracts / Plants, Medicinal / Plants, Toxic / Sesquiterpenes
(出版サイトへのリンク): ● Publication site (DOI): 10.1021/np9904298
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10785430; ● Search Scopus @ Elsevier (PMID): 10785430; ● Search Scopus @ Elsevier (DOI): 10.1021/np9904298

(DOI: 10.1021/np9904298, PubMed: 10785430) Yoshio Takeda, Hiroyuki Matsumura, Toshiya Masuda, Gisho Honda, Hideaki Otsuka, Yoshihisa Takaishi, Ekrem Sezikand and Erdem Yesilada :
Phlorigidosides A-C, iridoid glucosides from Phlomis rigida,
Phytochemistry, Vol.53, No.8, 931-935, 2000.

(要約): トルコ産Phlomis rigida地上部の配糖体成分を検索し，5種の既知物質とともに3種の新イリドイド配糖体を単離しその化学構造を明らかにした．
(キーワード): Glucosides / Iridoids / Magnetic Resonance Spectroscopy / Plant Extracts / Plants, Medicinal / Pyrans
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0031-9422(99)00431-8
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10820806; ● Summary page in Scopus @ Elsevier: 2-s2.0-0034716834

(DOI: 10.1016/S0031-9422(99)00431-8, PubMed: 10820806, Elsevier: Scopus) Reiko Fujita, Hongquan Duan and Yoshihisa Takaishi :
Terpenoids from Tripterigyum hypoglaucum,
Phytochemistry, Vol.53, No.6, 715-722, 2000.

(要約): Six terpenoids have been isolated from the root bark of Tripterygium hypoglaucum, along with 14 known compounds. The structures of the terpenoids were elucidated as 3,11,14-oxo-abieta-8,12-diene, 3beta-hydroxy-12,14-dimethoxyabieta-8,11,13-triene, 3beta-hydroxy-11alpha-ethoxyurs-12-ene, 3beta-hydroxy-11alpha-methoxyurs-12-ene, 3beta-hydroxy-11alpha-methoxyolean-12-ene-28-oic acid, and 1beta-benzoyl-8alpha-cinnamoyl-4alpha,5alpha- dihydroxydihydroagarofuran.
(キーワード): Tripterygium hypoglaucum / Celastraceae / Root bark / Triterpenoids
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0031-9422(99)00557-9
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10746886; ● Search Scopus @ Elsevier (PMID): 10746886; ● Search Scopus @ Elsevier (DOI): 10.1016/S0031-9422(99)00557-9

(DOI: 10.1016/S0031-9422(99)00557-9, PubMed: 10746886) Ping Zhou, Yoshihisa Takaishi, Hongquan Duan, Bei Chen, Gisho Honda, Michiho Itoh, Yoshio Takeda, Kodzhimatov K. Olimjon and Kuo-Hsing Lee :
Coumarins and bicoumarin from Ferula sumbul: anti-HIV activity and inhibition of cytokine release,
Phytochemistry, Vol.53, No.6, 689-697, 2000.

(要約): The methanol extract of the dried roots of Ferula sumbul afforded two furanocoumarin esters, fesumtuorin A, B, one bicoumarin, fesumtuorin C, five spirobicoumarins, fesumtuorin D, E, F, G and H, along with nineteen known coumarins. Their structures were established on the basis of spectroscopic studies. Some of the isolated compounds showed anti-HIV activity and very weak inhibition of cytokine release.
(キーワード): Ferula sumbul / Umbelliferae / Coumarin / Bicoumarin / Fesumtuorin
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0031-9422(99)00554-3
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10746882; ● Search Scopus @ Elsevier (PMID): 10746882; ● Search Scopus @ Elsevier (DOI): 10.1016/S0031-9422(99)00554-3

(DOI: 10.1016/S0031-9422(99)00554-3, PubMed: 10746882) Hongquan Duan, Yoshihisa Takaishi, Yasuhiro Imakura, Yongfong Jia, Duan Li, Mark L Cosentino and Kuo-Hsiung Lee :
Sesquiterpene Alkaloids from Tripterygium hypoglaucum and Tripterygium wilfordii: A New Class of Potent Anti-HIV Agents,
Journal of Natural Products, Vol.63, No.3, 357-361, 2000.

(要約): Five new sesquiterpene pyridine alkaloids [triptonines A (1) and B (2), and wilfordinines A (3), B (4), and C (5)] and two known compounds (peritassine A and hypoglaunine C) were isolated from Tripterygium hypoglaucum and a clinically used extract of Tripterygium wilfordii. The structures of 1-5 were elucidated by spectroscopic methods. The anti-HIV activity of 1, 2, and several related compounds was evaluated. Triptonine B (2) demonstrated potent anti-HIV activity with an EC(50) value of <0.10 microg/mL and an in vitro therapeutic index value of >1000.
(キーワード): Alkaloids / Anti-HIV Agents / HIV-1 / Microbial Sensitivity Tests / Molecular Structure / Plants, Medicinal / Sesquiterpenes / Spectrum Analysis
(出版サイトへのリンク): ● Publication site (DOI): 10.1021/np990281s
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10757718; ● Search Scopus @ Elsevier (PMID): 10757718; ● Search Scopus @ Elsevier (DOI): 10.1021/np990281s

(DOI: 10.1021/np990281s, PubMed: 10757718) Bei Chen, Kazuyoshi Kawazoe, Yoshihisa Takaishi, Gisho Honda, Michiho Itoh, Yoshio Takeda, Olimjon K. Kodzhimatov and Ozodbek Ashurmetov :
Prenylated Benzoic Acid Derivatives from Ferula kuhistanica,
Journal of Natural Products, Vol.63, No.3, 362-365, 2000.

(要約): Four new prenylated benzoic acid derivatives, kuhistanols A-D (1-4), along with one known compound, 3-farnesyl-p-hydroxybenzoic acid (5), have been isolated from the roots of the Uzbekistan medicinal plant, Ferula kuhistanica. Their structures were established on the basis of chemical and spectral evidence. Compound 4 showed a significant inhibitory effect on cytokine production in lipopolysaccharide-stimulated human peripheral mononuclear cells.
(キーワード): Apiaceae / Benzoic Acids / Cytokines / Humans / Lipopolysaccharides / Monocytes / Spectrum Analysis
(出版サイトへのリンク): ● Publication site (DOI): 10.1021/np990338a
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10757719; ● Search Scopus @ Elsevier (PMID): 10757719; ● Search Scopus @ Elsevier (DOI): 10.1021/np990338a

(DOI: 10.1021/np990338a, PubMed: 10757719) Bao-Ning Su, Yoshihisa Takaishi, Motoo Tori, Shigeru Takaoka, Gisho Honda, Michiho Itoh, Yoshio Takeda, Olimjon K. Kodzhimatov and Ozodbek Ashurmetov :
Macrophyllidimers A and B, two novel sesquiterpene dimers from the bark of Inula macrophylla,
Tetrahedron Letters, Vol.41, No.9, 1475-1479, 2000.

(キーワード): Inula macrophylla / Compositae / macrophyllidimers A and B / sesquiterpene dimer / NMR data / X-ray analysis
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0040-4039(99)02321-7
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1016/S0040-4039(99)02321-7

(DOI: 10.1016/S0040-4039(99)02321-7) Bao-Ning Su, Yoshihisa Takaishi, Motoo Tori, Shigeru Takaoka, Gisho Honda, Michiho Itoh, Yoshio Takeda, Olimjon K. Kodzhimatov and Ozodbek Ashurmetov :
Macrophyllols A and B, Two Unusual Novel Sesquiterpene and Monoterpene Dimers from the Bark of Inula macrophylla,
Organic Letters, Vol.2, No.4, 493-496, 2000.

(要約): [structure: see text] Two novel sesquiterpene and monoterpene dimers, macrophyllols A (1) and B (2), were isolated from the bark of Inula macrophylla. Their structures were determined on the basis of spectral evidence (especially HREIMS and 2D NMR) as well as chemical transformation. The structure of macrophyllol A (1) was confirmed by X-ray analysis. The possible biosynthetic pathways of macrophyllols A (1) and B (2) are discussed.
(キーワード): Dimerization / Inula / Magnetic Resonance Spectroscopy / Mass Spectrometry / Molecular Structure / Terpenes / Trees
(出版サイトへのリンク): ● Publication site (DOI): 10.1021/ol990401n
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10814359; ● Summary page in Scopus @ Elsevier: 2-s2.0-0034707972

(DOI: 10.1021/ol990401n, PubMed: 10814359, Elsevier: Scopus) Bao-Ning Su, Yoshihisa Takaishi, Gisho Honda, Michiho Itoh, Yoshio Takeda, Olimjon K. Kodzhimatov and Ozodbek Ashurmetov :
Sesquiterpene Coumarins and Related Derivatives from Ferula pallida,
Journal of Natural Products, Vol.63, No.4, 436-440, 2000.

(要約): Six new compounds-two sesquiterpene coumarins, pallidones A and B (1, 2), and four related derivatives, pallidones C-F (3-6), as well as two known sesquiterpene coumarins, feselol (7) and conferol (8), have been isolated from the EtOAc extracts of the roots of Ferula pallida. All structures of these compounds were determined on the basis of spectral evidence, especially 2D NMR ((1)H-(1)H COSY, HSQC, HMBC, and NOESY) and HRMS. The possible biosynthetic pathway of pallidones C-F (3-6) is discussed.
(キーワード): Coumarins / Ferula / Magnetic Resonance Spectroscopy / Mass Spectrometry / Plants, Medicinal / Plants, Toxic / Sesquiterpenes / Spectrophotometry, Infrared / Spectrophotometry, Ultraviolet
(出版サイトへのリンク): ● Publication site (DOI): 10.1021/np990262i
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10785409; ● Search Scopus @ Elsevier (PMID): 10785409; ● Search Scopus @ Elsevier (DOI): 10.1021/np990262i

(DOI: 10.1021/np990262i, PubMed: 10785409) Akira Iida, Tomohiro Mihara, Tetsuro Fujita and Yoshihisa Takaishi :
Peptidic immunosuppressants from the fungus Trichoderma polysporum,
Bioorganic & Medicinal Chemistry Letters, Vol.9, No.24, 3393-3396, 1999.

(要約): Three new 10-residue lipopeptaibols, trichopolyns III-V have been isolated from the fungus Trichoderma polysporum together with the known trichopolyns I and II. Structure determination has been achieved on the basis of spectroscopic and chemical evidence. These peptides have been shown to suppress the proliferation of lymphocytes in mouse allogeneic mixed lymphocyte reaction.
(キーワード): Animals / Anti-Bacterial Agents / Immunosuppressive Agents / Lymphocyte Culture Test, Mixed / Mass Spectrometry / Mice / Peptides / Protein Conformation / Trichoderma
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0960-894X(99)00621-6
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10617078; ● Search Scopus @ Elsevier (PMID): 10617078; ● Search Scopus @ Elsevier (DOI): 10.1016/S0960-894X(99)00621-6

(DOI: 10.1016/S0960-894X(99)00621-6, PubMed: 10617078) Bao-Ning Su, Yoshihisa Takaishi and Takenori Kusumi :
Morinols A-L, twelve novel sesquineolignans and neolignans with a new carbon skeleton from morina chinensis,
Tetrahedron, Vol.55, No.51, 14571-14586, 1999.

(キーワード): Morina chinensis / Dipsacaceae / neolignans / Sesquineolignans / new carbon skeleton / cytokine production, morinols A-L / enantiomeric natural product
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0040-4020(99)00933-3
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1016/S0040-4020(99)00933-3

(DOI: 10.1016/S0040-4020(99)00933-3) Bao-Ning Su and Yoshihisa Takaishi :
Morinols A and B, Two Novel Tetrahydropyran Sesquineolignans with a New Carbon Skeleton from Morina chinensis,
Chemistry Letters, Vol.28, No.12, 1315-1316, 1999. Hitomi Taninaka, Yoshihisa Takaishi, Gisho Honda, Yasuhiro Imakura, Ekrem Sezik and Erdem Yesilada :
Terpenoids and aromatic compounds from Daphne oleoides ssp. oleoides,
Phytochemistry, Vol.52, No.8, 1525-1529, 1999.

(キーワード): Terpenoid / Oleodaphnal / Oleodaphnone / Diterpene / Sesquiterpene / Daphne oleoides ssp. oleoides / Thymelaceae / Daphnane diterpenoids
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0031-9422(99)00305-2
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1016/S0031-9422(99)00305-2

(DOI: 10.1016/S0031-9422(99)00305-2) Kazuyoshi Kawazoe, Aki Yutani and Yoshihisa Takaishi :
Aryl naphthalenes norlignans from Vitex rotundifolia,
Phytochemistry, Vol.52, No.8, 1657-1659, 1999.

(キーワード): Vitex rotundifolia / Verbenaceae / Arylnaphthalene / Lignan / Vitrofolal
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0031-9422(99)00405-7
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1016/S0031-9422(99)00405-7

(DOI: 10.1016/S0031-9422(99)00405-7) Hongquan Duan and Yoshihisa Takaishi :
Sesquiterpene evoninate alkaloids from Tripterygium hypoglaucum,
Phytochemistry, Vol.52, No.8, 1735-1738, 1999.

(キーワード): Tripterygium hypoglaucum / Celastraceae / Root bark / Sesquiterpenes / Pyridine alkaloids / Hyponine
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0031-9422(99)00179-X
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1016/S0031-9422(99)00179-X

(DOI: 10.1016/S0031-9422(99)00179-X) Bao-Ning Su and Yoshihisa Takaishi :
Morinins L-P, Five New Phenylpropanol Derivatives from Morina chinensis,
Chemical & Pharmaceutical Bulletin, Vol.47, No.11, 1569-1572, 1999.

(キーワード): Morina chinensis / Dipsacaceae / phenylpropanol derivatives / morinin L-P

Hongquan Duan, Yoshihisa Takaishi, Yongfong Jia and Duan Li :
Sesquiterpene Alkaloids from Extracts of Tripterygium wilfordii,
Chemical & Pharmaceutical Bulletin, Vol.47, No.11, 1664-1667, 1999.

(キーワード): Tripterygium wilfordii / Celastraceae / sesquiterpene / wilfordinine

Hongquan Duan, Yoshihisa Takaishi, Hiroshi Momota, Yasukazu Ohmoto, Takao Taki, Yongfeng Jia and Duan Li :
Immunosuppressive Diterpenoids from Tripterygium wilfordii,
Journal of Natural Products, Vol.62, No.11, 1522-1525, 1999.

(要約): A clinically used extract of Tripterygium wilfordii afforded three new diterpenoids-3beta,19-dihydroxyabieta-8,11,13-triene (triptobenzene L) (1); 12,19-dihydroxy-3-oxoabieta-8,11,13-triene (triptobenzene M) (2); and 19-hydroxy-3,7-dioxo-abieta-8,11, 13-triene (triptobenzene N) (3)-along with 14 known diterpenoids. The structures of 1-3 were established on the basis of spectroscopic studies. Of the known compounds, the stereochemistry at C-4 of triptonediol (4) was reassigned. Tripterifordin (8) and 13-epi-manoyl oxide-18-oic acid (9) showed significant inhibitory effects on cytokine production.
(キーワード): Anti-Inflammatory Agents / Cytokines / Depression, Chemical / Diterpenes, Abietane / Humans / Immunosuppressive Agents / Magnetic Resonance Spectroscopy / Medicine, Chinese Traditional / Phenanthrenes / Plants, Medicinal / Prednisolone / Spectrophotometry, Infrared / Spectrophotometry, Ultraviolet
(出版サイトへのリンク): ● Publication site (DOI): 10.1021/np9902183
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10579865; ● Search Scopus @ Elsevier (PMID): 10579865; ● Search Scopus @ Elsevier (DOI): 10.1021/np9902183

(DOI: 10.1021/np9902183, PubMed: 10579865) Bao-Ning Su, Yoshihisa Takaishi, Hong-Quan Duan and Bei Chen :
Phenylpropanol Derivatives from Morina chinensis,
Journal of Natural Products, Vol.62, No.10, 1363-1366, 1999.

(要約): Seven new phenylpropanol derivatives, named morinins A-G (1-7), along with five known compounds, 4-O-methylcinnamyl alcohol, 4-O-methylcinnamyl methyl ether, 4-O-methylcinnamyl acetate, p-methoxybenzaldehyde, and 4-O-methyl-(E)-coniferyl alcohol, have been isolated from the roots of the medicinal Chinese plant, Morina chinensis. Their structures were determined on the basis of spectral data, especially 2D NMR and HRMS.
(出版サイトへのリンク): ● Publication site (DOI): 10.1021/np990091h
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10543893; ● Search Scopus @ Elsevier (PMID): 10543893; ● Search Scopus @ Elsevier (DOI): 10.1021/np990091h

(DOI: 10.1021/np990091h, PubMed: 10543893) Bao-Ning Su and Yoshihisa Takaishi :
Morinins H-K, Four Novel Phenylpropanol Ester Lipid Metabolites from Morina chinensis,
Journal of Natural Products, Vol.62, No.9, 1325-1327, 1999.

(要約): The medicinal plant, Morina chinensis, afforded four novel phenylpropanol ester lipid metabolites, named morinins H-K (1-4). Their structures were identified on the basis of spectral data interpretation.
(出版サイトへのリンク): ● Publication site (DOI): 10.1021/np990145n
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10514326; ● Search Scopus @ Elsevier (PMID): 10514326; ● Search Scopus @ Elsevier (DOI): 10.1021/np990145n

(DOI: 10.1021/np990145n, PubMed: 10514326) Yoshio Takeda, Toshiya Masuda, Gisho Honda, Yoshihisa Takaishi, Michiho Ito, Ozodebek A. Ashurmetov, Olimjon K. Khodzhimatov and Hideaki Otsuka :
Secoiridoid glycosides from Gentiana olivierii,
Chemical & Pharmaceutical Bulletin, Vol.47, No.9, 1338-1340, 1999.

(要約): ウズベキスタン産薬用植物Gentiana olivieri全草の成分について検討を加え，7種の既知セコイリドイド配糖体を同定すると共に，3種の新苦味セコイリドイド配糖体を単離しその化学構造を明らかにした．

Yesilada Erdem and Yoshihisa Takaishi :
A saponin with anti-ulcerogenic effect from the flowers of Spartium junceum,
Phytochemistry, Vol.51, No.7, 903-908, 1999.

(要約): A new oleanene-type saponin with potent anti-ulcerogenic activity was isolated from the flowers of Spartium junceum. The various techniques of NMR spectral analysis, viz. 1H, 13C, DEPT, C-H COSY, H-H COSY, COLOC, NOESY, HMBC, HMQC, in conjunction with EI- and FAB-mass spectrometry, revealed that the structure of the isolated saponin was 3-O-[alpha-L-rhamnopyranosyl-(1-->2) -O-beta-D-glucopyranosyl-(1-->2)-beta-D-glucuronopyranosyl]-3 beta,16beta,22 beta,24-tetrahydroxy-olean-12-ene and named as spartitrioside.
(キーワード): Spartium junceum L / Fabaceae / Spartitrioside / Triterpenic saponin / Oleanene-type saponin
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0031-9422(99)00198-3
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10423862; ● Search Scopus @ Elsevier (PMID): 10423862; ● Search Scopus @ Elsevier (DOI): 10.1016/S0031-9422(99)00198-3

(DOI: 10.1016/S0031-9422(99)00198-3, PubMed: 10423862) Bei Chen, Hongquan Duan and Yoshihisa Takaishi :
Triterpene caffeoyl esters and diterpenes from Celastrus stephanotifolius,
Phytochemistry, Vol.51, No.5, 683-687, 1999.

(キーワード): phytochemistry / plant extract / triterpene derivative / celastrus stephanotifolius extract / diterpene
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0031-9422(99)00079-5
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1016/S0031-9422(99)00079-5

(DOI: 10.1016/S0031-9422(99)00079-5) Hongquan Duan, Yoshihisa Takaishi, Masahiko Bando, Masaru Kido, Yasuo Imakura and KuoHsiung Lee :
Novel sesquiterpene esters with alkaloid and monoterpene and related compounds from Tripterygium hypoglaucum: A new class of potent anti-HIV agents,
Tetrahedron Letters, Vol.40, No.15, 2969-2972, 1999.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0040-4039(99)00339-1
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1016/S0040-4039(99)00339-1

(DOI: 10.1016/S0040-4039(99)00339-1) Erdem Yesilada, Ekrem Sezik, Gisho Honda, Yoshihisa Takaishi, Yoshio Takeda and Toshihiro Tanaka :
Traditional medicine in Turkey IX. Folk medicine in north west Anatolia,
Journal of Ethnopharmacology, Vol.64, No.3, 195-210, 1999.

(要約): トルコ共和国西北Anatolia地方の伝統薬について調査し，その起源植物，用法などについて報告した．
(キーワード): Northwest Anatolia / Traditional medicine / Turkey
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0378-8741(98)00133-0
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10363834; ● Search Scopus @ Elsevier (PMID): 10363834; ● Search Scopus @ Elsevier (DOI): 10.1016/S0378-8741(98)00133-0

(DOI: 10.1016/S0378-8741(98)00133-0, PubMed: 10363834) Kazuyoshi Kawazoe, Miyako Yamamoto, Yoshihisa Takaishi, Gisho Honda, Tetsuro Fujita, Ekrem Sezik and Erdem Yesilada :
Rearranged abietane-type diterpenes from Salvia dichroantha,
Phytochemistry, Vol.50, No.3, 493-497, 1999.

(キーワード): Salvia dichroantha / S. tomentosa / Labiatae / Dichroanal A / Dichroanal B / Dichroanone / Abietane
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0031-9422(98)00471-3
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1016/S0031-9422(98)00471-3

(DOI: 10.1016/S0031-9422(98)00471-3) Hongquan Duan and Yoshihisa Takaishi :
Structures of sesquiterpene polyol alkaloids from Tripterygium hypoglaucum,
Phytochemistry, Vol.49, No.7, 2185-2189, 1998.

(キーワード): Tripterygium hypoglaucum / Celastraceae / root bark / sesquiterpene / pyridine alkaloid / hypoglaunine
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0031-9422(98)00439-7
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1016/S0031-9422(98)00439-7

(DOI: 10.1016/S0031-9422(98)00439-7) Kenji Okazaki, Shigenori Nakayama, Kazuyoshi Kawazoe and Yoshihisa Takaishi :
Antiaggregant effects on human platelets of culinary herbs,
Phytotherapy Research, Vol.12, No.8, 603-605, 1998.

(キーワード): herb / platelet aggregation / marjoram / arbutin
(出版サイトへのリンク): ● Publication site (DOI): 10.1002/(SICI)1099-1573(199812)12:8<603::AID-PTR372>3.0.CO;2-G
(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-0032410826

(DOI: 10.1002/(SICI)1099-1573(199812)12:8<603::AID-PTR372>3.0.CO;2-G, Elsevier: Scopus) Kimiko Nakano, Chaiki Yoshida, Wakako Furukawa, Yoshihisa Takaishi and Kozo Shishido :
Terpenoids in Transformed Root Culture of Tripterygium Wilfordii,
Phytochemistry, Vol.49, No.6, 1821-1824, 1998. Kimiko Nakano, Chaiki Yoshida, Wakako Furukawa, Yoshihisa Takaishi and Kozo Shishido :
Terpenoids in transformed root culture of Tripterygium wilfordii,
Phytochemistry, Vol.49, No.6, 1821-1824, 1998.

(要約): Investigation of a hairy root culture of Tripterygium wilfordii var. regelii transformed with Agrobacterium rhizogenes resulted in the isolation of new diterpenoid and sesquiterpenoid together with known triterpenoids. These structures were determined by spectroscopic analyses.
(キーワード): Tripterygium wilfordii var. regelii / Celastraceae / hairy root / Agrobacterium rhizogenes / abietane diterpenoid / dihydroagarofuran sesquiterpenoids / CMR
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0031-9422(98)00300-8
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11711110; ● Search Scopus @ Elsevier (PMID): 11711110; ● Search Scopus @ Elsevier (DOI): 10.1016/S0031-9422(98)00300-8

(DOI: 10.1016/S0031-9422(98)00300-8, PubMed: 11711110) Yasuhiro Imakura, Takuji Kawata, Hidemitu Hara, Yukitaka Hayafuji, Tetsuro Singhu, Shigeru Kobayashi, Kazuyoshi Kawazoe, Yoshihisa Takaishi, Toshihiro Hashimoto and Shinsuke Yamasita :
Three β-coumaranones from Sparaxis tricolor,
Phytochemistry, Vol.48, No.7, 1179-1185, 1998.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0031-9422(97)00935-7
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1016/S0031-9422(97)00935-7

(DOI: 10.1016/S0031-9422(97)00935-7) Erdem Yesilada, Didem Deliorman, Fatma Ergun, Yoshihisa Takaishi and Yukihisa Ono :
Effects of the Turkish subspecies of Viscum album on macrophage-derived cytokines,
Journal of Ethnopharmacology, Vol.61, No.3, 195-200, 1998.

(要約): Viscum album L. herbs are used for the treatment of various diseases. Apart from their immunostimulatory, antitumor, and hypotension inducing activities, anti-inflammatory effects has also been recorded in the literature. Since the immunostimulatory activity of mistletoe is mainly attributed to a stimulation of the mononuclear phagocytic system and to an induction of inflammation by macrophage-derived cytokines, utilization based on anti-inflammatory activity seems in contrast with its use as immunostimulant. The inhibitory effects of 80% ethanol extracts and subfractions obtained by petroleum ether, diethylether, ethylacetate and n-butanol from three Turkish subspecies of V. album L. (ssp. album, ssp. abietis, ssp. austriacum) against interleukins (IL-1alpha and IL-1beta) and tumor necrosis factor-alpha were studied. Ethanolic (80%) extracts of all three subspecies exhibited almost no significant inhibitory activity on the proinflammatory cytokines, at least in the concentrations applied in this study. In contrast, they induce a concentration dependent stimulation of these cytokines. On the other hand, moderate to weak, dose dependent inhibitory effects were observed on fractionation, which may be attributed to the existence of less polar components with anti-inflammatory activity. Based on our results, it was concluded that the utilization of ethanol extracts for anti-inflammatory purposes would not be beneficial probably due to the partial extraction of the low-molecular-weight polypeptides, i.e. viscotoxins, which induce an inflammatory response. Moreover, for anti-inflammatory effects, extracts of Viscum album ssp. austriacum may be preferred, since higher inhibitory ratios were obtained against inflammatory cytokines than with the other two subspecies.
(キーワード): Interleukin-1α / Interleukin-1β / Loranthaceae / Mistletoe / Tumor necrosis factor-α / Viscum album ssp. abietis / Viscum album ssp.album / Viscum album ssp. austriacum
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0378-8741(98)00038-5
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 9705010; ● Search Scopus @ Elsevier (PMID): 9705010; ● Search Scopus @ Elsevier (DOI): 10.1016/S0378-8741(98)00038-5

(DOI: 10.1016/S0378-8741(98)00038-5, PubMed: 9705010) J Oto, Z Islam, Yoshihisa Takaishi and N Sakato :
Biological Activity of the Triterpene Celastrol : Analysis from the Viewpoint of the Apoptosis Induction,
Technical Bulletein of Faculty of Agriculture, Vol.50, 79-87, 1998. Kimiko Nakano, Yoshiko Oose and Yoshihisa Takaishi :
A novel epoxy-triterpene and nortriterpene from callus cultures of Tripterygium wilfordii,
Phytochemistry, Vol.46, No.7, 1179-1182, 1997.

(キーワード): Tripterygium wilfordii var. regelii / Celastraceae / tissue culture / epoxy-triterpene / nortriterpene / triptocallic acid / CMR
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0031-9422(97)80007-6
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1016/S0031-9422(97)80007-6

(DOI: 10.1016/S0031-9422(97)80007-6) Mineo Niwa, Noriko Nakamura, Keiko Kitajima, Mari Ueda, Yasuyuki Tsutsumishita, Shiroh Futaki and Yoshihisa Takaishi :
Benzoquinones Inhibit the Expression of Inducible Nitric Oxide Synthase Gene`,
Biochemical and Biophysical Research Communications, Vol.239, No.2, 367-371, 1997.

(要約): Benzoquinones inhibited the production of NO induced by LPS and gamma-IFN in C6 glia cells. The mechanistic studies showed that benzoquinones inhibited the expression of iNOS mRNA through inactivation of NF kappa B. Benzoquinones may be a useful candidate for the development of a drug to treat disease due to iNOS gene over-expression.
(キーワード): Animals / Benzoquinones / Gene Expression Regulation, Enzymologic / Genes / Neuroglia / Nitric Oxide Synthase / RNA, Messenger / Rats / Tumor Cells, Cultured
(出版サイトへのリンク): ● Publication site (DOI): 10.1006/bbrc.1997.7437
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 9344836; ● Search Scopus @ Elsevier (PMID): 9344836; ● Search Scopus @ Elsevier (DOI): 10.1006/bbrc.1997.7437

(DOI: 10.1006/bbrc.1997.7437, PubMed: 9344836) Hongquan Duan, Kazuyoshi Kawazoe, Masahiko Bando, Masaru Kido and Yoshihisa Takaishi :
Di- and triterpenoids from Tripterygium hypoglaucum,
Phytochemistry, Vol.46, No.3, 535-543, 1997.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0031-9422(97)00288-4
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1016/S0031-9422(97)00288-4

(DOI: 10.1016/S0031-9422(97)00288-4) Da-Peng Hu, Kazuyoshi Kawazoe and Yoshihisa Takaishi :
Diterpenoids from Salvia splendens,
Phytochemistry, Vol.46, No.4, 781-784, 1997.

(キーワード): Salvia splendens / Labiatae / diterpene / clerodan / splenolide
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0031-9422(97)00180-5
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1016/S0031-9422(97)00180-5

(DOI: 10.1016/S0031-9422(97)00180-5) Erdem Yesilada, Osman Üstün, Ekrem Sezik, Yoshihisa Takaishi, Yukihisa Ono and Gisho Honda :
Inhibitory effects of Turkish folk remedies on inflammatory cytokines: interleukin-1α, interleukin-1β and tumor necrosis factor α,
Journal of Ethnopharmacology, Vol.58, No.1, 59-73, 1997.

(キーワード): Turkish folk medicine / Interleukin-1 inhibition / Tumor necrosis factor inhibition
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0378-8741(97)00076-7
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1016/S0378-8741(97)00076-7

(DOI: 10.1016/S0378-8741(97)00076-7) Yoshihisa Takaishi, Noriko Wariishi, Hideo Tateishi, Kazuyoshi Kawazoe, Kimiko Nakano, Yukihisa Ono, Haruyuki Tokuda, Hoyoku Nishino and Akio Iwashima :
Triterpenoid inhibitors of interleukin-1 secretion and tumour-promotion from Tripterygium wilfordii var. regelii,
Phytochemistry, Vol.45, No.5, 969-974, 1997.

(キーワード): Tripterygium wilfordii / Celastraceae / triterpene / regeol / interleukin-1 / antitumour-promoting activity
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0031-9422(96)00859-X
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1016/S0031-9422(96)00859-X

(DOI: 10.1016/S0031-9422(96)00859-X) Yoshihisa Takaishi, Kaname Miyagi, Kazuyoshi Kawazoe, Kimiko Nakano, Kunhua Li and Hongquan Duan :
Terpenoids from Tripterygium wilfordii var. regelii,
Phytochemistry, Vol.45, No.5, 975-978, 1997.

(キーワード): Tripterygium wilfordii / Celastraceae / triterpene / diterpene / regelone
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0031-9422(96)00860-6
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1016/S0031-9422(96)00860-6

(DOI: 10.1016/S0031-9422(96)00860-6) Yoshihisa Takaishi, Noriko Wariishi, Hideo Tateishi, Kazuyoshi Kawazoe, Kaname Miyagi, Kunhua Li and Hongquan Duan :
Phenolic diterpenes from Tripterygium wilfordii var. regelii,
Phytochemistry, Vol.45, No.5, 979-984, 1997.

(キーワード): Triptepygium wilfordii / Celastraceae / stems / bark / diterpene / triptobenzene
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0031-9422(96)00861-8
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1016/S0031-9422(96)00861-8

(DOI: 10.1016/S0031-9422(96)00861-8) Yoshihisa Takaishi, Yoshito Murakami, Minoru Uda, Takashi Ohashi, Noriko Hamamura, Masaru Kidota and Shigetosi Kadota :
Hydroxyphenylazoformamide derivatives from Calvatia craniformis,
Phytochemistry, Vol.45, No.5, 997-1001, 1997.

(キーワード): Calvatia craniformis / higher fungi / Gastromycetes / craniformin / hydroxyphenylazoformamide derivatives
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0031-9422(97)00066-6
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1016/S0031-9422(97)00066-6

(DOI: 10.1016/S0031-9422(97)00066-6) Kunhua Li, Hongquan Duan, Kazuyoshi Kawazoe and Yoshihisa Takaishi :
Terpenoids from Tripterygium wilfordii,
Phytochemistry, Vol.45, No.4, 791-796, 1997.

(キーワード): Tripterygium wilfordii / Celastraceae / root barks / triterpene / diterpene / wilforic acid / triptobenzene
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0031-9422(97)00048-4
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1016/S0031-9422(97)00048-4

(DOI: 10.1016/S0031-9422(97)00048-4) Hongquan Duan, Kazuyoshi Kawazoe and Yoshihisa Takaishi :
Sesquiterpene alkaloids from Tripterygium hypoglaucum and Tripterygium wilfordii: A New Class of Potent Anti-HIV Agents,
Phytochemistry, Vol.45, No.3, 617-621, 1997.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0031-9422(96)00875-8
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1016/S0031-9422(96)00875-8

(DOI: 10.1016/S0031-9422(96)00875-8) Kimiko Nakano, Yoshiko Oose, Yuuko Masuda, Hikari Kamada and Yoshihisa Takaishi :
A diterpenoid and triterpenes from tissue cultures of Tripterygium wilfordii,
Phytochemistry, Vol.45, No.2, 293-296, 1997.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0031-9422(96)00858-8
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1016/S0031-9422(96)00858-8

(DOI: 10.1016/S0031-9422(96)00858-8) Kazuyoshi Kawazoe, Naoko Shimogai, Yoshihisa Takaishi, K. Sundar Rao and Yasuhiro Imakura :
Four stilbenes from Salacia lehmbachii,
Phytochemistry, Vol.44, No.8, 1569-1573, 1997.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0031-9422(96)00768-6
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1016/S0031-9422(96)00768-6

(DOI: 10.1016/S0031-9422(96)00768-6) Ekrem Sezik, Erdem Yesilada, Mamoru Tabata, Gisho Honda, Yoshihisa Takaishi, Tetsuro Fujita, Toshihiro Tanaka and Yoshio Takeda :
Traditional medicine in Turkey. VIII. Folk medicine in east Anatolia ; Erzurum, Erzincan, Agri, Kars, Igdir Provinces,
Economic Botany, Vol.51, No.3, 195-211, 1997. Gisho Honda, Erdem Yeşilada, Mamoru Tabata, Ekrem Sezik, Tetsuro Fujita, Yoshio Takeda, Yoshihisa Takaishi and Toshihiro Tanaka :
Traditional medicine in Turkey VI. Folk medicine in West Anatolia: Afyon, Kütahya, Denizli, Muğla, Aydin provinces,
Journal of Ethnopharmacology, Vol.53, No.2, 75-87, 1996.

(キーワード): Traditional medicine / Turkey / West Anatolia
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0378-8741(96)01426-2
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1016/S0378-8741(96)01426-2

(DOI: 10.1016/S0378-8741(96)01426-2) Mineo Niwa, Yasuyuki Tsutsumishita, Yumiko Kawai, Hideo Takahara, Noriko Nakamura, Shiroh Futaki, Yoshihisa Takaishi, Wataru Kondoh and Hideki Moritoki :
Suppression of Inducible Nitric Oxide Synthase mRNA Expression by Tryptoquinone A,
Biochemical and Biophysical Research Communications, Vol.224, No.2, 579-585, 1996.

(要約): Triptoquinone A (TQA), which is an anti-inflammatory constituent in plants, was studied for its suppressive effect on nitric oxide production by LPS. TQA significantly suppressed smooth muscle relaxation and increase in cyclic GMP levels by nitric oxide (NO) in an L-arginine-induced relaxation experiment. The mechanistic studies showed that TQA did not directly inhibit NO radicals and inducible nitric oxide synthase (iNOS) enzyme but suppressed IL-1 beta and iNOS mRNA expression by LPS. The suppression level of iNOS gene expression by TQA was comparable to that by dexamethasone. TQA may be a useful candidate for the development of a drug as a potent inhibitor of iNOS gene over-expression.
(キーワード): Animals / Anti-Inflammatory Agents, Non-Steroidal / Aorta, Thoracic / Arginine / Base Sequence / Cyclic GMP / DNA Primers / Dexamethasone / Diterpenes / Gene Expression Regulation, Enzymologic / Interleukin-1 / Isoenzymes / Kinetics / Male / Molecular Sequence Data / Muscle Relaxation / Muscle, Smooth, Vascular / Nitric Oxide Synthase / Nitroprusside / Phenylephrine / Plants / Polymerase Chain Reaction / RNA, Messenger / Rats / Rats, Wistar / Time Factors / Transcription, Genetic / Vasodilator Agents
(出版サイトへのリンク): ● Publication site (DOI): 10.1006/bbrc.1996.1067
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 8702429; ● Search Scopus @ Elsevier (PMID): 8702429; ● Search Scopus @ Elsevier (DOI): 10.1006/bbrc.1996.1067

(DOI: 10.1006/bbrc.1996.1067, PubMed: 8702429) Hideki Moritoki, Tetsuhiro Hisayama, Kann Kida, Wataru Kondoh, Shinnichi Inoue and Yoshihisa Takaishi :
Inhibition by triptoquinone-A of LPS- and IL-1β-primed induction of no synthase in rat thoracic aorta,
Life Sciences, Vol.59, No.3, PL49-PL54, 1996.

(キーワード): triptoquinone-A / endotoxin (LPS) / interleukin-1β / aorta / L-arginine-induced relaxation / cGMP / nitrite / nitric oxide synthase induction
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/0024-3205(96)00283-4
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1016/0024-3205(96)00283-4

(DOI: 10.1016/0024-3205(96)00283-4) Kyoko Hayashi, Toshimitsu Hayashi, Kunie Ujita and Yoshihisa Takaishi :
Characterization of antiviral activity of a sesquiterpene, triptofordin C-2,
The Journal of Antimicrobial Chemotherapy, Vol.37, No.4, 759-768, 1996. Kimiko Nakano, Yuu Kanai, Ktaro Murakami and Yoshihisa Takaishi :
Cucurbitacin glycosides from Caput nigri,
Phytochemistry, Vol.39, No.1, 205-207, 1995.

(キーワード): Caput nigri / Cucurbitaceae / roots / Cabeça-de-negro / cucurbitacin glycoside / cabenosides I-L
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/0031-9422(94)00872-Q
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1016/0031-9422(94)00872-Q

(DOI: 10.1016/0031-9422(94)00872-Q) Kimiko Nakano, Yuu Kanai, Kotaro Murakami and Yoshihisa Takaishi :
Cucurbitacin glycosides from cabeça-de-negro,
Phytochemistry, Vol.39, No.1, 209-211, 1995.

(キーワード): Caput nigri / Cucurbitaceae / Cabeça-de-negro / roots / cucurbitacin glycoside / bryodulcosigenin / cabenoside D-H
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/0031-9422(94)00869-U
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1016/0031-9422(94)00869-U

(DOI: 10.1016/0031-9422(94)00869-U) Akira Iida, Y Tanaka, T Mihara, Mamoru Tabata, Gisho Honda, Tetsuro Shingu, Yoshio Takeda, Yoshihisa Takaishi, Erdem Yesilada, Ekrem Sezik and Tetsuro Fujita :
Marrubinones A and B, New Labdane Diterpenoids from Marrubium astracanicum(Labiatae),
Chemical & Pharmaceutical Bulletin, Vol.43, No.9, 1454-1457, 1995. Erdem Yesilada, Gisho Honda, Ekrem Sezik, Mamoru Tabata, Tetsuro Fujita, Toshihiro Tanaka, Yoshio Takeda and Yoshihisa Takaishi :
Traditional medicine in Turkey. VII: Folk medicine in middle and west Black Sea regions,
Economic Botany, Vol.49, No.4, 406-422, 1995.

(要約): トルコ共和国黒海中西部沿岸の伝統薬について現地調査し，起源植物，用法などについて記述した．

Kimiko Nakano, Yuu Kanai, Kotaro Murakami, Yoshihisa Takaishi and Toshiaki Tomimatsu :
Nor-cucurbitacin glucosides from Caputo nigri,
Phytochemistry, Vol.37, No.3, 817-820, 1994.

(キーワード): Caputo nigri / Cucurbitaceae / Cabeça-de-negro / nor-cucurbitacin glucosides / hexa-nor-cucurbitacin glucoside / cabenoside
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0031-9422(00)90363-7
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1016/S0031-9422(00)90363-7

(DOI: 10.1016/S0031-9422(00)90363-7) Hironori Sassa, Kentaro Kogure, Yoshihisa Takaishi and Hiroshi Terada :
Structural basis of potent antiperoxidation activity of the triterpene celastrol in mitochondria: Effect of negative membrane surface charge on lipid peroxidation,
Free Radical Biology and Medicine, Vol.17, No.3, 201-207, 1994.

(キーワード): Triterpene / Celastrol / Mitochondria / Lipid peroxidation / Iron-induced lipid peroxidation / Surface chrage / Ferrous ion / Free radicals
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/0891-5849(94)90075-2
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1016/0891-5849(94)90075-2

(DOI: 10.1016/0891-5849(94)90075-2) Kozo Shishido, Kimiko Nakano, Noriko Wariishi, Hideo Tateishi, Tomoki Omodani, Masayuki Shibuya, Kiyoto Goto, Yukihisa Ono and Yoshihisa Takaishi :
Tripterygium wilfordii var. regelii which are interleukin-1 inhibitors,
Phytochemistry, Vol.35, No.3, 731-737, 1994.

(キーワード): Tripterygium wilfordii / Celastraceae / diterpene / triptoquinone / interleukin-1
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0031-9422(00)90596-X
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1016/S0031-9422(00)90596-X

(DOI: 10.1016/S0031-9422(00)90596-X) Kozo Shishido, Kiyoto Goto, Shizuka Miyoshi, Yoshihisa Takaishi and Masayuki Shibuya :
Synthetic studies on diterpenoid quinones with interleukin-1 inhibitory activity. Total synthesis of (.+-.)- and (+)-triptoquinone A,
The Journal of Organic Chemistry, Vol.59, No.2, 406-414, 1994.

(出版サイトへのリンク): ● Publication site (DOI): 10.1021/jo00081a021
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1021/jo00081a021

(DOI: 10.1021/jo00081a021) M. Okuda, A. Iida and Yoshihisa Takaishi :
Fungal Metabolites X. The effect of Peptide Antibiotics, Trichosporins-Bs, on the Respiratory Activity of Mitochondria,
Biological & Pharmaceutical Bulletin, Vol.17, 482-485, 1994. K. Matuura, O. Shoma and Yoshihisa Takaishi :
Fungal Metabolites XV. Primary Structures of Antibiotic Peptides,Hypelcins B-I ,B-II ,B-III ,B-IV and B-V from Hypocrea peltata,
Chemical & Pharmaceutical Bulletin, Vol.42, 1063-1069, 1994. Tetsuro Fujita, Yoshihisa Takaishi, Yoshio Takeda, Tetsuji Fujiyama and Takahito Nishi :
Fungal metabolites. II. Structure elucidation of minor metabolites, valinotricin, cyclonerodiol oxide, and epicyclonerodiol oxide, from Trichoderma polysporum,
Chemical & Pharmaceutical Bulletin, Vol.32, No.11, 4419-4425, 1984.

(要約): 木材腐朽菌Trichoderma polysporumの微量代謝産物を検索し，N-formylvalinとN-formylvalinolのエステルであるvalinotricin,テルペン性cyclonerodiol及びepicyclonerodiolを単離し，その化学構造を決定した．

MISC

川添和義, 伏谷秀治, 柏田良樹, 佐々木久子, 大道由佳, 栗本慎一郎, 篠崎陽介, 柴山恵美子, 関田倫彦, 金子礼, 洲山佳寛, 高岸佐和, 中野芙佐子, 平田藍, 宮崎祐樹, 田島壮一郎, 櫻田巧, 中川博之, 田岡寛之, 足立麻美, 柴田高洋, 岡田直人, 継岡知美, 淵上美由紀, 小中健, 今林潔, 今林優佳, 高石喜久, 水口和生 :
つるぎ町一宇地区の民間薬調査,
阿波学会紀要, No.57, 89-98, 2011年. 川添和義, 伏谷秀治, 柏田良樹, 田中直伸, 岡坂衛, 石田俊介, 鎌倉孝法, 佐藤昌俊, 橋田千佳, 西迫寛隆, 田島壮一郎, 森剛志, 鈴木恭子, 橋田和佳, 部屋衣美子, 高田千絵, 遠藤友香, 金尚永, 田岡寛之, 西村和也, 高石喜久, 水口和生 :
三好市東祖谷地区の民間薬調査,
阿波学会紀要, No.53, 87-98, 2007年. 村上光太郎, 菅愛, 越智俊政, 中川博之, 近藤京子, 田中直伸, 湯浅修子, 梅本怜美, 岡坂衛, 河野正治, 佐川貴昭, 山﨑真知, 片岡麻衣, 川口陽祐, 駒木根希, 白鳥水紀, 田畑麻美, 川添和義, 高石喜久 :
三野町の民間薬調査,
阿波学会紀要, No.49, 85-94, 2003年.

総説・解説

高石喜久 :
天然医薬品と健康食品,
四国医学雑誌, Vol.63, No.5,6, 164-169, 2007年12月.

(徳島大学機関リポジトリ): ● Metadata: 110194

(徳島大学機関リポジトリ: 110194) 高石喜久, Freddy A. Ramos, 田所哲男, 竹内実 :
玉葱皮に含まれる新規な抗菌・抗酸化化合物,
New Food Industry, Vol.49, No.11, 1-8, 2007年11月.

講演・発表

Sang-Yong Kim, Naonobu Tanaka, Yoshiki Kashiwada, Yoshihisa Takaishi, Jun'ichi Kobayashi and Mareshige Kojoma :
Studies on the constituents of Chloranthus japonicus sieb.,
Planta Medica, Vol.80, 784, Oxford, Mississipi, USA, Aug. 2014.

(出版サイトへのリンク): ● Publication site (DOI): 10.1055/s-0034-1382457
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1055/s-0034-1382457

(DOI: 10.1055/s-0034-1382457) Yoshihiro Suyama, Naonobu Tanaka, Shin-ichiro Kurimoto, Kazuyoshi Kawazoe, Kotarou Murakami, Han-Dong Sun, Shun-Lin Li, Yoshihisa Takaishi and Yoshiki Kashiwada :
Studies on medicinal plants of Yunnan province: constituents of Gentiana rigescens,
Planta Medica, Vol.80, 785, Oxford, Mississipi, USA, Aug. 2014.

(出版サイトへのリンク): ● Publication site (DOI): 10.1055/s-0034-1382458
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1055/s-0034-1382458

(DOI: 10.1055/s-0034-1382458) Ishii Yasuyo, Kim Sang-Yong, Yoshihisa Takaishi and Yoshiki Kashiwada :
Hydroxycinnamoyl 1,2-dihydro¬furo[3,2-e]tryptamine derivatives from defatted safflower seeds.,
International Congress on Natural Products Research, New York, Jul. 2012. Kurimoto Shin-ichiro, Pu Jian-Xin, Sun Han-Dong, Yoshihisa Takaishi and Yoshiki Kashiwada :
Sesterterpenoids and diterpenoids from the aerial parts of Scutellaria coleifolia Levl,
International Congress on Natural Products Research, New York, Jul. 2012. Sasaki Hisako, Sato Hisayo, Yoshiki Kashiwada, Kazuyoshi Kawazoe, Kotarou Murakami, Hirofumi Shibata, Sun Han-Dong, Li Shun-Lin and Yoshihisa Takaishi :
Studies on the constituents of Cudrania tricuspidata,
International Congress on Natural Products Research, New York, Jul. 2012. Kim Sang-Yong, Yoshiki Kashiwada, Kazuyoshi Kawazoe, Kotarou Murakami, Sun Han-Dong, Li Shun-Lin and Yoshihisa Takaishi :
STUDIES ON THE CONSTITUENTS OF CHLORANTHUS SPICATUS (THUNB.) MAKINO,
2011 AMERICAN SOCIETY OF PHARMACOGNOSY ANNUAL MEETING, 74, San Diego, Aug. 2011. Sasaki Hisako, Yoshiki Kashiwada, Hirofumi Shibata and Yoshihisa Takaishi :
STUDIES ON THE CONSTITUENTS OF DESMODIUM CAUDATUM,
2011 AMERICAN SOCIETY OF PHARMACOGNOSY ANNUAL MEETING, San Diego, Aug. 2011. Omichi Yuka, Kurimoto Shin-ichiro, Yoshiki Kashiwada, Hirofumi Shibata, Miyake Yoshiyuki, Kirimoto Tsukasa and Yoshihisa Takaishi :
THE CONSTITUENTS OF THE FLOWER BUDS OF LONICERA JAPONICA AND THEIR ANTI-INFLUENZA ACTIVITIY,
2011 AMERICAN SOCIETY OF PHARMACOGNOSY ANNUAL MEETING, 66, San Diego, Aug. 2011. Yoshiki Kashiwada, Xiong Juan, Chen Chin-Ho, Qian Keduo, Morris-Natschke L. Susan, Lee Hsiung Kuo and Yoshihisa Takaishi :
CONJUGATES OF BEVIRIMAT WITH BETURIN DERIVATIVES AS ANTI-HIV AGENTS,
2011 AMERICAN SOCIETY OF PHARMACOGNOSY ANNUAL MEETING, 66, Aug. 2011. Kurimoto Shin-ichiro, Yoshiki Kashiwada, Lee Kuo-Hsiung and Yoshihisa Takaishi :
CHEMICAL STUDY ON DYSOXYLUM CUMINGIANUM (MELIACEAE),
2011 AMERICAN SOCIETY OF PHARMACOGNOSY ANNUAL MEETING, 58, San Diego, Jul. 2011. Daisuke Tsuji, T Koyama, Yoshiki Kashiwada, Yoshihisa Takaishi and Kouji Itou :
Lycorine induces differentiation from embryonic stem cells into PSA-NCAM-positive cells,
ICS2010, Chiba, Aug. 2010. Yoshihisa Takaishi, Yoshiki Kashiwada, Hashida Waka, Mikuchi Kousuke and Koichiro Tsuchiya :
FERULOYL MUCIC ACID DERIVATIVES AS SIRT1 STUMULATOR FROM CITRUS SUDACHI HORT. EX SHIRAI.,
50th Annual Meeting of the American Society of Pharmacognosy, Honolulu, Jun. 2009. Yoshiki Kashiwada, Xiong Juan, Kilgore R. Nicole, Wild T. Carl, Allaway P. Graham, Lee Kuo-Hsiung and Yoshihisa Takaishi :
3-O-ACYL BETULIN DERIVATIVE AND AZT CONJUGATE AS ANTI-HIV AGENTS.,
50th Annual Meeting of the American Society of Pharmacognosy, Honolulu, Jun. 2009. Xiong Juan, Taniguchi Masatoshi, Yoshiki Kashiwada, Yamagishi Takashi and Yoshihisa Takaishi :
AMIDE DERIVATIVES OF PAPYRIFERIC ACID AS MDR-REVERSING AGENTS.,
50th Annual Meeting of the American Society of Pharmacognosy, Honolulu, Jun. 2009. Kim Sang-Yong, Yoshiki Kashiwada, Kazuyoshi Kawazoe, Kotarou Murakami, Sun Han-Dong, Li Shun-Lin and Yoshihisa Takaishi :
STUDIES ON THE CONSTITUENTS OF CHLORANTHUS SPICATUS (THUNB.) MAKINO.,
50th Annual Meeting of the American Society of Pharmacognosy, Honolulu, Jun. 2009. Kurimoto Shin-ichiro, Suzuki Kyoko, Yoshiki Kashiwada, Okasaka Mamoru, Kodzhimatov K. Olimjon and Yoshihisa Takaishi :
STUDY ON MEDICINAL PLANTS OF UZBEKISTAN: CONSTITUENTS OF THE ROOTS OF FERULA VARIA (SCHRENK) TRAUTV.,
50th Annual Meeting of the American Society of Pharmacognosy., Honolulu, Jun. 2009. Sang-Yong Kim, Yoshiki Kashiwada, Yoshihisa Takaishi, Kazuyoshi Kawazoe, Kotarou Murakami and Shun-Lin Li :
Studies on the constituents of Chloranthus spicatus (Thumb.) Makino.,
7th Joint Meeting of AFERP, ASP, GA, PSE&SIF, 1059, Athens, Aug. 2008. Yoshiki Kashiwada, Masatoshi Taniguchi, Xiong Juan, Takashi Yamagishi and Yoshihisa Takaishi :
Triterpene derivatives and their reversing activity against multidrug resistant cancer cells.,
7th Joint Meeting of AFERP, ASP, GA, PSE&SIF, Athens, Aug. 2008. 川添和義, 坪内良子, Abdullah Norasyikin, 高石喜久, 柴田洋文, 樋口富彦, 堀均 :
ワタヨモギに含まれるセスキテルペン成分,
国際精油シンポジウム, 273-275, 徳島, 2002年10月. 北岡和義, 吉田博, 伊藤健太, 金井純子, , 寺田賢治, 高石喜久 :
学生の社会実装を支援する助成金「仁生イノベーショングラント」の実施，課題とその改善,
イノベーション教育学会第6回年次大会, 2018年12月. 森岡諒, 金尚永, 長嶋紘紗子, 田中直伸, 柏田良樹, 高石喜久, 小林淳一, 高上馬希重 :
ヒトリシズカ(Chloranthus japonicus)地上部より単離した新規C25テルペノイドの構造,
日本生薬学会北海道支部第41回例会, 2017年5月. 森岡諒, 金尚永, 長嶋紘紗子, 田中直伸, 高石喜久, 柏田良樹, 小林淳一, 高上馬希重 :
北海道産ヒトリシズカ(Chloranthus japonicus)地上部の成分研究,
日本薬学会第137年会, 2017年3月. 森越祥太, 金尚永, 坂井大地, 増子ひとみ, 田中直伸, 柏田良樹, 高石喜久, 小林淳一, 高上馬希重 :
センリョウ科植物フタリシズカ(Chloranthus serratus)地上部の成分研究,
日本生薬学会第63回年会, 295, 2016年9月. 金尚永, 長嶋紘紗子, 田中直伸, 柏田良樹, 高石喜久, 小林淳一, 高上馬希重 :
センリョウ科植物ヒトリシズカ(Chloranthus japonicus)地上部の成分研究,
日本生薬学会第63回年会, 294, 2016年9月. 金尚永, 長嶋紘紗子, 田中直伸, 高石喜久, 柏田良樹, 小林淳一, 高上馬希重 :
ヒトリシズカ(Chloranthus japonicus)地上部より単離したC25テルペノイドの構造,
第58回天然有機化合物討論会, 445-450, 2016年9月. 金尚永, 長嶋絋紗子, 田中直伸, 柏田良樹, 高石喜久, 小林淳一, 高上馬希重 :
センリョウ科植物ヒトリシズカ (Chloranthus japonicus) 地上部の成分研究,
日本薬学会第136年会, Vol.2, 226, 2016年3月. 洲山佳寛, 田中直伸, 栗本慎一郎, 川添和義, 村上光太郎, 孫漢董, 李順林, 高石喜久, 柏田良樹 :
雲南省産伝統薬物に関する研究(26)–Gentiana rigescensの成分研究(6)–,
第54回日本薬学会中国四国支部学術大会, 124, 2015年10月. 坂井大地, 金尚永, 増子ひとみ, 田中直伸, 柏田良樹, 高石喜久, 小林淳一, 高上馬希重 :
センリョウ科植物フタリシズカ(Chloranthus serratus)地上部の成分研究,
日本生薬学会第62回年会, 134, 2015年9月. 長嶋絋紗子, 金尚永, 田中直伸, 川野辺弘子, 柏田良樹, 高石喜久, 小林淳一, 高上馬希重 :
センリョウ科植物ヒトリシズカ(Chloranthus japonicus)地上部の成分研究,
日本生薬学会第62回年会, 133, 2015年9月. 長嶋絋紗子, 金尚永, 田中直伸, 柏田良樹, 高石喜久, 小林淳一, 高上馬希重 :
センリョウ科植物Chloranthus japonicusの成分について,
日本生薬学会北海道支部第39回例会, 68, 2015年5月. 坂井大地, 増子ひとみ, 金尚永, 田中直伸, 柏田良樹, 高石喜久, 小林淳一, 高上馬希重 :
センリョウ科植物Chloranthus serratusの成分について,
日本生薬学会北海道支部第39回例会, 68, 2015年5月. 金尚永, 田中直伸, 柏田良樹, 高石喜久, 小林淳一, 高上馬希重 :
センリョウ科植物ヒトリシズカ(Chloranthus japonicus)地上部の成分について,
日本薬学会第135年会, Vol.2, 228, 2015年3月. 洲山佳寛, 田中直伸, 栗本慎一郎, 川添和義, 村上光太郎, 孫漢董, 李順林, 高石喜久, 柏田良樹 :
雲南省伝統薬物に関する研究(25) -Gentiana rigescensの成分研究(5)-,
第53回日本薬学会中国四国支部学術大会, 157, 2014年11月. 栗本慎一郎, 柏田良樹, 高石喜久, 普建新, 孫漢董, 中村隆典 :
シソ科植物Scutellaria coleifoliaのジテルペノイド成分,
第56回天然有機化合物討論会, 291-296, 2014年10月. 金尚永, 田中直伸, 柏田良樹, 高石喜久, 小林淳一, 前田桂, 高上馬希重 :
センリョウ科植物ヒトリシズカ(Chloranthus japonicus)の成分について,
日本生薬学会第61回年会, 143, 2014年9月. 金尚永, 田中直伸, 柏田良樹, 高石喜久, 小林淳一, 高上馬希重 :
センリョウ科植物Chloranthus japonicusの成分について,
日本生薬学会北海道支部第38回例会, 68, 2014年5月. 武方みなみ, 栗本慎一郎, 高石喜久, 川添和義, 村上光太郎, Dorjval Enkhjargal, Damdinjav Davaadagva, 柏田良樹 :
モンゴル民族伝統薬物に関する研究(4)-Gentiana algida地上部の成分研究(1)-,
日本薬学会第134年会, Vol.2, 163, 2014年3月. 小早川夏樹, 栗本慎一郎, 高石喜久, 川添和義, 村上光太郎, Dorjval Enkhjargal, Damdinjav Davaadagva, 柏田良樹 :
モンゴル民族伝統薬物に関する研究(3)-Sanguisorba officinalis花部の成分研究(2)-,
日本薬学会第134年会, Vol.2, 163, 2014年3月. 市川沙季, 栗本慎一郎, 川添和義, 村上光太郎, 孫漢董, 李順林, 高石喜久, 柏田良樹 :
雲南省産伝統薬物に関する研究(25) –Potentilla freyniana地上部の成分研究-,
日本薬学会第134年会, Vol.2, 163, 2014年3月. 洲山佳寛, 栗本慎一郎, 川添和義, 村上光太郎, 孫漢董, 李順林, 高石喜久, 柏田良樹 :
雲南省産伝統薬物に関する研究(24) –Gentiana rigescensの成分研究 (4)-,
日本薬学会第134年会, Vol.2, 163, 2014年3月. 栗本慎一郎, 普建新, 孫漢董, 高石喜久, 柏田良樹 :
シソ科植物Scutellaria coleifolia地上部の成分研究(6),
日本薬学会第134年会, Vol.2, 65, 2014年3月. 栗本慎一郎, 普建新, 孫漢董, 高石喜久, 柏田良樹 :
シソ科植物Scutellaria coleifolia地上部の成分研究(5),
第52回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, 197, 2013年10月. 市川沙季, 栗本慎一郎, 川添和義, 村上光太郎, 孫漢董, 李順林, 高石喜久, 柏田良樹 :
雲南省産伝統薬物に関する研究(23) –Potentilla freyniana地上部の成分研究(1)-,
第52回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, 197, 2013年10月. 小笠紗也加, 川添和義, 村上光太郎, Dorjval Enkhjargal, Damdinjav Davaadagva, 高石喜久, 柏田良樹 :
モンゴル民族伝統薬物に関する研究(2)-Paeonia anomala根の成分研究(1),
第52回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, 196, 2013年10月. 橋本敏弘, 吉川和子, 谷沙希子, 山下智子, 井関賀奈子, 山本博文, 今川洋, 柏田良樹, 高石喜久, 馬場正樹, 岡田嘉仁, 河野幸子 :
シンビジウムグレートフラワー・マリーローランサンの葉に含まれる新規トリテルペン,
第57回香料・テルペンおよび精油化学に関する討論会, 2013年10月. 中野扶佐子, 栗本慎一郎, 川添和義, 村上光太郎, 孫漢董, 李順林, 高石喜久, 宮本理人, 土屋浩一郎, 柏田良樹 :
キク科植物Saussurea lanicepsの成分研究,
第55回天然有機化合物討論会, 2013年9月. 金尚永, 柏田良樹, 高石喜久, 川添和義, 村上光太郎, 孫漢董, 李順林, 高上馬希重 :
センリョウ科Chloranthus spicatus根の成分研究,
日本生薬学会第60回年会, 280, 2013年9月. 佐々木久子, 柴田洋文, 今林潔, 高石喜久, 柏田良樹 :
ミソナオシDesmodium caudatumの成分研究(8)–植物和名の由来に関する科学的検討-,
日本生薬学会第60回年会, 243, 2013年9月. 中野扶佐子, 栗本慎一郎, 川添和義, 村上光太郎, 孫漢董, 李順林, 高石喜久, 柏田良樹 :
雲南省産伝統薬物に関する研究(20) –Saussurea lanicepsの成分研究 (2)-,
日本生薬学会第60回年会, 195, 2013年9月. 洲山佳寛, 栗本慎一郎, 川添和義, 村上光太郎, 孫漢董, 李順林, 高石喜久, 柏田良樹 :
雲南省産伝統薬物に関する研究(21) –Gentiana rigescensの成分研究 (3)-,
日本生薬学会第60回年会, 196, 2013年9月. 栗本慎一郎, 普建新, 孫漢董, 高石喜久, 柏田良樹 :
シソ科植物Scutellaria coleifolia地上部の成分研究(4),
日本生薬学会第60回年会, 78, 2013年9月. 佐々木久子, 柏田良樹, 柴田洋文, 高石喜久 :
ミソナオシDesmodium caudatumの成分研究(7),
日本薬学会第133年会, 2013年3月. 吉川和子, 山下智子, 井関賀奈子, 山本博文, 今川博, 柏田良樹, 高石喜久, 馬場正樹, 岡田嘉仁, 河野幸子, 橋本敏弘 :
シンビジウムグレートフラワー・マリーローランサンの葉のNO酸性抑制活性成分(2),
日本薬学会第133年会, 2013年3月. 佐渡香織, 栗本慎一郎, 高石喜久, 吉川和子, 橋本敏弘, 河野道郎, 河野幸子, 柏田良樹 :
シンビジウムグレートフラワー・マリーローランサン葉の成分について(5),
日本薬学会第133年会, 2013年3月. 中野扶佐子, 川添和義, 村上光太郎, 孫漢董, 李順林, 高石喜久, 柏田良樹 :
雲南省産伝統薬物に関する研究(19)—Saussurea lanicepsの成分研究(1)—,
日本薬学会第133年会, 2013年3月. 洲山佳寛, 栗本慎一郎, 川添和義, 村上光太郎, 孫漢董, 李順林, 高石喜久, 柏田良樹 :
雲南省産伝統薬物に関する研究(18) —Gentiana rigescens根の成分研究(2)—,
日本薬学会第133年会, 2013年3月. 栗本慎一郎, 普建新, 孫漢董, 高石喜久, 柏田良樹 :
シソ科植物Scutellaria coleifolia地上部の成分研究(3),
日本薬学会第133年会, 2013年3月. 洲山佳寛, 栗本慎一郎, 川添和義, 村上光太郎, 孫漢董, 李順林, 高石喜久, 柏田良樹 :
雲南省産伝統薬物に関する研究(17) —Gentiana rigescens根の成分研究(1)—,
日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, 2012年11月. 佐々木久子, 柏田良樹, 柴田洋文, 高石喜久 :
ミソナオシDesmodium caudatumの成分研究(6),
日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, 2012年11月. 佐渡香織, 栗本慎一郎, 高石喜久, 吉川和子, 橋本敏弘, 河野道郎, 河野幸子, 柏田良樹 :
Cymbidium Great Flower葉部の成分研究,
日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, 2012年11月. 小早川夏樹, 栗本慎一郎, 高石喜久, 川添和義, 村上光太郎, Dorjval Enkhjaragal, Damdinjv Davaadagva, 柏田良樹 :
モンゴル民族伝統薬物に関する研究(1) —Sanguisorba officinalis花部の成分研究(1) —,
日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, 2012年11月. 中野扶佐子, 高石喜久, 位上健太郎, 下条洋輔, 宮﨑寿次, 柏田良樹 :
発酵オタネ人参のアセトアミノフェン肝障害抑制成分の探索,
日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, 2012年11月. 栗本慎一郎, 普建新, 孫漢董, 高石喜久, 柏田良樹 :
シソ科植物Scutellaria coleifolia地上部の成分研究,
第54回天然有機化合物討論会, 2012年9月. 石井康世, 中野扶佐子, 高石喜久, 柏田良樹 :
ベニバナ(Carthamus tinctorius)脱脂種子に含まれる機能性成分の探索研究(4),
日本生薬学会第59回年会, 2012年9月. 金子礼, 柏田良樹, 高石喜久, 川添和義, 村上光太郎, 孫漢董, 李順林 :
雲南省伝統薬物に関する研究(16)—Kadsura interiaの成分について(2)—,
日本生薬学会第59回年会, 2012年9月. 栗本慎一郎, 普建新, 孫漢董, 高石喜久, 柏田良樹 :
シソ科植物Scutellaria coleifolia地上部の成分研究(1),
日本生薬学会第59回年会, 2012年9月. 石井康世, 柏田良樹, 高石喜久 :
ベニバナ脱脂種子の成分研究(3),
日本薬学会第132年会, No.2, 119, 2012年3月. 栗本慎一郎, 柏田良樹, 高石喜久 :
バングラデシュ産薬用植物に関する研究(3)-Azadirachta indicaの成分研究(2)-,
日本薬学会第132年会, No.2, 118, 2012年3月. 位上健太郎, 下条洋輔, 下条洋輔, 宮崎寿次, 中野扶佐子, 柏田良樹, 高石喜久 :
発酵オタネ人参のアセトアミノフェン肝障害抑制メカニズムの解明と有効成分の探索,
日本薬学会第132年会, No.2, 245, 2012年3月. 佐々木久子, 佐藤寿代, 柏田良樹, 川添和義, 村上光太郎, 柴田洋文, 孫漢董, 李順林, 高石喜久 :
雲南省産伝統薬物に関する研究(18)-Cudrania tricuspidataの成分研究-,
日本薬学会第132年会, No.2, 107, 2012年3月. 成相祐希, Hiroyuki Mizuguchi, 永井浩章, 金山知代, 加藤周平, Yoshiyuki Yoshimura, Yoshiki Kashiwada, Hisao Nemoto, Yoshihisa Takaishi, Noriaki Takeda and Hiroyuki Fukui :
Identification of the target molecule of the new anti-allergic compound, maackiain from Kujin,
第85回日本薬理学会年会, Mar. 2012. 石井康世, 金尚永, 柏田良樹, 高石喜久 :
ベニバナ(Carthamus tinctorius)脱脂種子に含有される機能性成分の探索研究(2)-,
第50回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, 109, 2011年11月. 靳美娜, 柏田良樹, 姚智, 段宏泉, 高石喜久 :
Shisandra propinquaの成分研究(1),
第50回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, 108, 2011年11月. 栗本慎一郎, 柏田良樹, 高石喜久 :
センダン科Azadirachta indicaの成分研究(1),
第50回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, 108, 2011年11月. 成相祐希, 水口博之, 永井浩章, 金山知代, 加藤周平, 柏田良樹, 根本尚夫, 高石喜久, 武田憲昭, 福井裕行 :
苦参由来新規抗アレルギー成分 maackiain の単離・合成および作用機序に関する研究,
第 50 回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, 2011年11月. 柴山恵美子, 柏田良樹, 土橋良太, 金城順英, 清水寛, 高石喜久 :
エラグ酸誘導体の肝保護作用について,
第50回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, 109, 2011年10月. 佐々木久子, 柏田良樹, 柴田洋文, 高石喜久 :
ミソナオシDesmodium caudatumの成分研究(5)-含有成分の抗MRSA・抗真菌活性について-,
日本生薬学会第58回年会, 324, 2011年9月. 大道由佳, 栗本慎一郎, 柏田良樹, 柴田洋文, 高石喜久, 三宅美行, 桐本吏 :
抗インフルエンザ活性天然物に関する研究(2)-金銀花(Lonicera japonica)の成分について-,
日本生薬学会第58回年会, 177, 2011年9月. 石井康世, 柏田良樹, 高石喜久 :
ベニバナ(Carthamus tinctorius)脱脂種子に含有される機能性成分の探索研究,
日本生薬学会第58回年会, 162, 2011年9月. Ahmed Ali Fakhruddin, 金尚永, 栗本慎一郎, 佐々木久子, 柴田洋文, 柏田良樹, 高石喜久 :
バングラデシュ産薬用植物に関する研究(1)-マメ科植物Butea monosperma花部について-,
日本生薬学会第58回年会, 85, 2011年9月. 成相祐希, 水口博之, 金山知代, 加藤周平, 永井浩章, 柏田良樹, 根本尚夫, 高石喜久, 武田憲昭, 福井裕行 :
苦参から見出された新規抗アレルギー成分 maackiain の単離・同定およびその性質について,
第15回活性アミンに関するシンポジウム, 2011年8月. 福井裕行, 金山知代, 加藤周平, 成相祐希, 馬場祐子, 水口博之, 柏田良樹, 根本尚夫, 高石喜久 :
苦参由来 IL-4 遺伝子発現抑制物質,
第28回和漢医薬学会学術大会, 2011年8月. 赤池雅史, 土屋浩一郎, 柏田良樹, 高石喜久, 玉置俊晃, 岩瀬俊, 佐田政隆, 粟飯原賢一, 吉田守美子, 松本俊夫, 佐藤千穂, 西条伴香, 楊河宏章 :
生活習慣病関連リスクファクターに及ぼすスダチ果皮加工品の効果 ∼探索的臨床試験による検討∼,
第243回徳島医学会学術集会公開シンポジウム, 2011年7月. 赤池雅史, 土屋浩一郎, 柏田良樹, 高石喜久, 玉置俊晃, 岩瀬俊, 佐田政隆, 粟飯原賢一, 吉田守実子, 松本俊夫, 佐藤千穂, 西条伴香, 楊河宏章 :
生活習慣病関連リスクファクターに及ぼすスダチ果皮加工品の効果-探索的臨床試験による検討-,
第243回徳島医学会学術集会, 2011年7月. 佐々木久子, 柏田良樹, 柴田洋文, 高石喜久 :
ミソナオシDesmodium caudatumの成分研究(4),
日本薬学会第131年会講演要旨集, Vol.2, 238, 2011年3月. 大道由佳, 柏田良樹, 柴田洋文, 高石喜久 :
抗インフルエンザ活性天然物に関する研究(1)―金銀花(Lonicera japonica)について,
日本薬学会第131年会講演要旨集, Vol.2, 244, 2011年3月. 熊娟, 谷口昌聖, 柏田良樹, 高石喜久 :
多剤薬剤耐性克服作用を有する天然物に関する研究(10)―シラカバ花穂トリテルペンpapyriferic acid のアミド誘導体の耐性克服作用―,
日本薬学会第131年会講演要旨集, Vol.2, 249, 2011年3月. 栗本慎一郎, 柏田良樹, 李國雄, 高石喜久 :
センダン科Dysoxylum cumingianum の成分研究(4),
日本薬学会第131年会講演要旨集, Vol.2, 249, 2011年3月. 辻大輔, 難波建多郎, 浦上裕行, 辻耕平, 重永章, 大髙章, 柏田良樹, 高石喜久, 伊藤孝司 :
ヒトiPS細胞に対する神経分化誘導能を持つ新規化合物の探索,
日本薬学会第131年会, 2011年3月. 成相祐希, 水口博之, 金山知代, 加藤周平, 柏田良樹, 根本尚夫, 高石喜久, 武田憲昭, 福井裕行 :
苦参から見出された新規抗アレルギー成分maackiainの単離・同定およびその性質について (Isolation and characterization of new anti-allergenic compound, maackiain from Kujin),
日本薬学会年会, 2011年3月. 金尚永, 柏田良樹, 川添和義, 村上光太郎, 孫漢董, 李順林, 高石喜久 :
雲南省産伝統薬物に関する研究 (17) - Chloranthus spicatus の成分について (9) -,
日本薬学会第131年会講演要旨集, Vol.2, 83, 2011年3月. 成相祐希, 水口博之, 金山知代, 永井浩章, 加藤周平, 柏田良樹, 根本尚夫, 高石喜久, 武田憲昭, 福井裕行 :
苦参から見出された新規抗アレルギー成分maackiainの単離・同定およびその性質について,
2010感染免疫クラスター・ミニリトリート, 2011年1月. 葛西彩香, 木下正文, 足立美佳, 盛重純一, 瓜倉真衣, 里内清, 柏田良樹, 今林潔, 高石喜久, 田中保, 德村彰 :
種々の食材中の創傷治癒性リン脂質含量,
日本農芸化学会中国四国支部第29回講演会，講演要旨集, 28, 2011年1月. 水口博之, 金山知代, 成相祐希, 加藤周平, 柏田良樹, 根本尚夫, 川添和義, 高石喜久, 福井裕行 :
和漢薬苦参に見いだされたアレルギー疾患感受性遺伝子発現抑制作用を有する新規抗アレルギー化合物の同定,
BMB2010,第33回日本分子生物学会年会第83回日本生化学会大会合同大会, 2010年12月. 辻大輔, 難波建多郎, 浦上裕行, 重永章, 大髙章, 柏田良樹, 高石喜久, 伊藤孝司 :
未分化細胞に対する神経分化誘導作用を持つ化合物の探索と構造活性相関,
BMB2010(第33回日本分子生物学会年会・第83回日本生化学会大会合同大会), 2010年12月. 水口博之, 金山知代, 成相祐希, 永井浩章, 加藤周平, 柏田良樹, 根本尚夫, 川添和義, 高石喜久, 福井裕行 :
和漢薬苦参に見出されたアレルギー疾患感受性遺伝子発現抑制作用を有する新規抗アレルギー化合物の同定,
BMB2010, 2010年12月. 奥村千恵子, 杉村真由美, 阿部真治, 米田良子, 上村卓広, 溝口徹也, 寺岡和彦, 久次米敏秀, 川添和義, 水口和生, 東満美, 高石喜久 :
「病院実務実習」における指導薬剤師と薬学部実務家教員の連携,
第31回徳島大学薬学部卒後教育公開講座, 2010年12月. 杉村真由美, 奥村千恵子, 東満美, 高石喜久 :
平成22年度徳島大学薬学部薬学科薬局実務実習を終えて∼学生アンケート結果を踏まえて∼,
第31回徳島大学薬学部卒後教育公開講座, 2010年12月. 金子礼, 柏田良樹, 川添和義, 村上光太郎, 孫漢董, 李順林, 高石喜久 :
雲南省伝統薬物に関する研究(16)—Kadsura interiorの成分について(1)—,
第49回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会要旨集, 136, 2010年11月. 篠崎陽介, 柏田良樹, 高石喜久 :
オトギリソウ科Hypericum属植物に関する研究(24)—キンシバイHypericum patulum花部の成分について(4)—,
第49回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会要旨集, 135, 2010年11月. 佐々木久子, 柏田良樹, 柴田洋文, 高石喜久 :
ミソナオシDesmodium caudatumの成分研究(3),
第49回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会要旨集, 134, 2010年11月. 栗本慎一郎, 柏田良樹, 李國雄, 高石喜久 :
センダン科Dysoxylum cumingianumの成分研究(3),
第49回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会要旨集, 133, 2010年11月. 金尚永, 柏田良樹, 高石喜久, 川添和義, 村上光太郎, 孫漢董, 李順林 :
雲南省伝統薬物に関する研究(15)—Chloranthus spicatusの成分について(8)—,
第49回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会要旨集, 133, 2010年11月. 佐々木久子, 柏田良樹, 柴田洋文, 高石喜久 :
ミソナオシDesmodium caudatumの成分研究(3),
第49回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, 2010年11月. 金尚永, 柏田良樹, 高石喜久, 川添和義, 村上光太郎, 孫漢董, 李順林 :
雲南省伝統薬物に関する研究(14)—Chloranthus spicatusの成分について(7)—,
本生薬学会第57回年会, 302, 2010年10月. 金山知代, 水口博之, 加藤周平, 成相祐希, 柏田良樹, 根本尚夫, 高石喜久, 福井裕行 :
苦参に含まれるアレルギー疾患感受性遺伝子発現を標的とする新規抗アレルギー成分の単離と同定,
第14回日本ヒスタミン学会, 2010年10月. 栗本慎一郎, 柏田良樹, 高石喜久, 李國雄 :
センダン科Dysoxylum cumingianumの成分研究(2),
日本生薬学会第57回年会要旨集, 366, 2010年9月. 田中直伸, 大谷美央, 小林淳一, 柏田良樹, 高石喜久, 芝崎あずさ, 五ノ井透, 城始勇 :
ナガサキオトギリより単離した新規prenylated acylphloroglucinol, petiolin J-Mの構造,
日本生薬学会第57回年会要旨集, 363, 2010年9月. 佐々木久子, 柏田良樹, 柴田洋文, 高石喜久 :
ミソナオシDesmodium caudatumの成分研究(2),
日本生薬学会第57回年会講演要旨集, 342, 2010年9月. 金山知代, 水口博之, 加藤周平, 成相祐希, 柏田良樹, 根本尚夫, 高石喜久, 福井裕行 :
苦参に含まれるアレルギー疾患感受性遺伝子発現抑制物質の単離と同定,
第27回和漢医薬学会, 2010年8月. 熊娟, 谷口昌聖, 柏田良樹, 高石喜久, 山岸喬 :
Dammarane Triterpenes from the Floral Spikes of Betula platyphylla var. japonica,
日本生薬学会第57回年会要旨集, 359, 2010年8月. 金山知代, 水口博之, 加藤周平, 成相祐希, 柏田良樹, 根本尚夫, 高石喜久, 福井裕行 :
苦参に含まれるアレルギー疾患感受性遺伝子発現抑制物質の単離と同定,
第117回日本薬理学会近畿部会, 2010年7月. 辻大輔, 小山毅, 浦上裕行, 難波建多郎, 柏田良樹, 高石喜久, 伊藤孝司 :
ヒガンバナ科植物由来アルカロイドLycorineの神経分化誘導作用,
第51回日本生化学会中国・四国支部例会, 2010年5月. 田中直伸, 久保田高明, 柏田良樹, 高石喜久, 小林淳一 :
ナガサキオトギリより単離した新規benzophenone rhamnosideの構造,
日本薬学会第130年会, No.2, 233, 2010年3月. 栗本慎一郎, 柏田良樹, Lee Kuo-Hsiung, 高石喜久 :
センダン科Dysoxy cumingianumの成分研究,
日本薬学会第130年会, No.2, 233, 2010年3月. 田中美音, 柏田良樹, 高石喜久 :
Triterpene Glycosides from Una de Gato (Uncaria tomentosa).,
日本薬学会第130年会, No.2, 225, 2010年3月. 佐々木久子, 柏田良樹, 柴田洋文, 高石喜久 :
ミソナオシDesmodium caudatumの成分研究,
日本薬学会第130年会, No.2, 224, 2010年3月. 熊娟, 柏田良樹, Chen Chin-Ho, Lee Kuo-Hsiung, 高石喜久 :
Research on Anti-HIV Natural Products (25) –Betulin Derivatives and AZT conjugates as Anti-HIV Agents with Multi-Mechanisms of Action-,
日本薬学会第130年会, No.2, 222, 2010年3月. 柴山恵美子, 柏田良樹, 関谷倫子, 高石喜久 :
多剤耐性克服作用を有する天然物に関する研究(9)—エラグ酸誘導体のp糖タンパク質昨日に及ぼす影響—,
日本薬学会第130年会, Vol.2, 221, 2010年3月. 池田康将, 土屋浩一郎, 田島壮一郎, 堀ノ内裕也, 木平孝高, 石澤啓介, 冨田修平, 高石喜久, 玉置俊晃 :
徳島県名産スダチ果皮の抗生活習慣病作用,
第83回日本薬理学会年会シンポジウム「肥満の栄養ゲノミクスと薬理ゲノミクス」, 2010年3月. 高石喜久, 柏田良樹, 橋田和佳, 北岡信, 三口弘介, 中川剛夫, 土屋浩一郎, 井端和郎 :
スダチ(Citrus sudachi)果皮のSIRT1活性化成分について,
第3回食品薬学シンポジウム, 114-116, 2009年11月. 佐々木久子, 岡本由梨恵, 柏田良樹, 川添和義, 村上光太郎, 李順林, 高石喜久 :
雲南省産伝統薬物に関する研究(13) -根辣Schizomussaenda dehiscensの成分研究(1)-,
第48回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, 2009年11月. 篠崎陽介, 橋田和佳, 柏田良樹, 高石喜久 :
オトギリソウ科Hypericum属植物に関する研究(23) -キンシバイHypericum patulum花部の成分について(3)-,
日本生薬学会第56回年会, 270, 2009年10月. 栗本慎一郎, 西村和也, 柏田良樹, 高石喜久 :
夏蠟梅Sinocalycanthus chinensisの成分研究(2),
日本生薬学会第56回年会, 259, 2009年10月. 金尚永, 柏田良樹, 高石喜久, 関谷倫子, 池城安正, Ramos Freddy :
Inula helenium葉含有セスキテルペンの細胞毒性活性,
日本生薬学会第56回年会, 109, 2009年10月. 三木あかね, 菊石美也子, 日野出晴美, 東満美, 樋口富彦, 土屋浩一郎, 木原勝, 高石喜久 :
徳島大学薬学部における自学能力育成への取組,
日本薬学会129年会, 0, 2009年3月. 柏田良樹, 熊娟, R. Nicole Kirgore, T. Carl Wirl, P. Graham Allaway, Kuo-Hsiung Lee, 高石喜久 :
抗HIV天然物に関する研究 (23) -ベツリンをリードとしたマルチメカニズムな抗HIV活性分子の創成研究-,
日本薬学会第129年会, No.2, 226, 2009年3月. 熊娟, 谷口昌聖, 柏田良樹, 山岸喬, 高石喜久 :
Research on Plant-Derived MDR-Reversing Agents (7): Amide Derivatives of Papyriferic Acid as MDR-reversing Agents.,
日本薬学会第129年会, No.2, 227, 2009年3月. 佐々木久子, 阿部有里子, 柏田良樹, 関谷倫子, 池城安正, 高石喜久 :
前駆脂肪細胞の分化調節機能を有する天然物(4)—青ジソ根部の分化抑制作用成分について—,
日本薬学会第129年会, No.2, 208, 2009年3月. 栗本慎一郎, 鈴木恭子, 岡坂衛, 柏田良樹, 伊藤美千穂, 本多義昭, 武田美雄, Kodzhimatov K. Olimjon, Ashurmetov Ozodbek, 高石喜久 :
ウズベキスタン産薬用植物に関する研究(36)—Ferula variaの成分研究(4) —,
薬学会第129年会, No.2, 227, 2009年3月. 金尚永, 柏田良樹, 川添和義, 村上光太郎, 孫漢董, 李順林, 高石喜久 :
雲南省産伝統薬物に関する研究(12)—Chloranthus spicatus の成分について(6)—,
薬学会第129年会, No.2, 96, 2009年3月. 吉川和子, 大津未早, 國土直樹, 河野幸子, 高石喜久, 橋本敏弘 :
シンビジウム・マリーサンローランサンの化学成分とそれらの生物活性について,
日本薬学会第129年会, No.2, 171, 2009年3月. 田中直伸, 大豆村拓自, 久保田高明, 今林潔, 柏田良樹, 高石喜久, 小林淳一 :
ビヨウヤナギより単離した新規xanthone誘導体の構造,
日本薬学会第129年会, No.2, 172, 2009年3月. 柴田洋文, 吉田敦也, 大野三規, 三谷明彦, 高石喜久 :
電圧負荷による非凍結低温度帯における低温細菌の挙動,
第29回日本食品微生物学術総会, 2008年11月. 篠崎陽介, 橋田和佳, 柏田良樹, 高石喜久 :
オトギリソウ科Hypericum 属植物に関する研究(22)—キンシバイ(Hypericum patulum)花部の成分について(2)—,
第47回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, 206, 2008年11月. 金尚永, 柏田良樹, 川添和義, 村上光太郎, 孫漢董, 李順林, 高石喜久 :
雲南省産伝統薬物に関する研究(11)—Chloranthus spicatus の成分について(5)—,
第47回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, 199, 2008年11月. 金尚永, 柏田良樹, 川添和義, 村上光太郎, 李順林, 孫漢董, 高石喜久 :
Chloranthus spicatusの成分研究,
第50回天然有機化合物討論会, 339-344, 2008年9月. 鎌倉孝法, 柏田良樹, 柴田洋文, 樋口富彦, 高石喜久 :
キク科カレープラントHelichrysum itallicum subsp. serotinumの抗MRSA活性成分の探索研究,
日本生薬学会第55回(2008)年会, 279, 2008年9月. 海瀬貞夫, 柏田良樹, 高石喜久, 孫漢董, 橋田千佳 :
オトギリソウ科Hypericum属植物に関する研究(19) —遍地金Hypericum elodeoidesの成分について(2)—,
日本生薬学会第55回(2008)年会, 243, 2008年9月. 田中直伸, 久保田高明, 石山玄明, 柏田良樹, 高石喜久, 伊藤淳二, 三上㐮, 城始勇, 小林淳一 :
ナガサキオトギリ由来の新規フロログルシノール誘導体petiolin Dの構造,
日本生薬学会第55回(2008)年会, 188, 2008年9月. 金尚永, 柏田良樹, 川添和義, 村上光太郎, 李順林, 高石喜久 :
雲南省産伝統薬物に関する研究(9)—Chloranthus spicatusの成分について(4)—,
日本生薬学会第55回(2008)年会, 187, 2008年9月. 橋田千佳, 田中直伸, 柏田良樹, 高石喜久, 孫漢董 :
オトギリソウ科Hypericum属植物に関する研究(19) —遍地金Hypericum elodeoidesの成分について(1)—.,
日本生薬学会第55回(2008)年会, 103, 2008年9月. 篠崎陽介, 橋田和佳, 柏田良樹, 高石喜久 :
オトギリソウ科Hypericum属植物に関する研究(21) —キンシバイHypericum patulum花部の成分について(1)—.,
日本生薬学会第55回(2008)年会, 102, 2008年9月. 栗本慎一郎, 鈴木恭子, 柏田良樹, 高石喜久, 岡坂衛, Kodozhimatov K. Olimjon, Ashurmetov Ozodbek :
ウズベキスタン産薬用植物に関する研究(35)—Mediasia macrophyllaの成分について(2)—.,
日本生薬学会第55回(2008)年会, 101, 2008年9月. 西村和也, 柏田良樹, 高石喜久 :
雲南省産伝統薬物に関する研究(10)—夏蝋梅(Sinocalycanthus chinensis)の成分について—.,
日本生薬学会第55回(2008)年会, 86, 2008年9月. 三橋洋介, 柏田良樹, 石田俊介, 高石喜久, Kodozhimatov K. Olimjon, Ashurmetov Ozodbek :
ウズベキスタン産薬用植物に関する研究(34) —Ziziphora pedicellataの成分について(2)—,
日本生薬学会第55回(2008)年会, 85, 2008年9月. 鎌倉孝法, 三浦理恵, 柏田良樹, 関谷倫子, 一柳孝司, 池城安正, 高石喜久 :
前駆脂肪細胞の分化調節機能を有する天然物(3)—かきのもとの分化促進作用成分について—,
薬学会第129年会, No.2, 208, 2008年3月. 田中直伸, 久保田高明, 荒木敦, 柏田良樹, 高石喜久, 三上襄, 小林淳一 :
ナガサキオトギリより単離した新規フロログルシノール誘導体petiolin A–Cの構造,
日本薬学会第128年会要旨集, 2008年3月.

(要約): -

金尚永, 柏田良樹, 高石喜久, 川添和義, 村上光太郎, 李順林 :
Chloranthus spicatusの成分研究,
日本薬学会第128年会要旨集, -, 2008年3月.

(要約): -

橋田和佳, 田中直伸, 柏田良樹, 高石喜久 :
Hypericum ascyronの成分研究 (5),
日本薬学会第128年会要旨集, -, 2008年3月.

(要約): -

柏田良樹, 高石喜久, Chin-Ho Chen, Kuo-Hsiung Lee :
抗HIV天然物に関する研究(22)–Oleanolic acid及びursolic acidの28-amido誘導体の抗HIV活性–,
日本薬学会第128年会要旨集, 2008年3月.

(要約): -

鈴木恭子, 岡坂衛, 柏田良樹, 高石喜久, 伊藤美千穂, 本多義昭, 武田美雄, Olimjon K. Kodzhimatov, Ozodbek Ashurmetov :
ウズベキスタン産薬用植物Ferula variaの成分研究(3),
日本薬学会第128年会要旨集, -, 2008年3月.

(要約): -

谷口昌聖, 熊娟, 柏田良樹, 高石喜久, 山岸喬 :
多剤薬剤耐性克服作用を有する点物に関する研究(5) –シラカバ花穂トリテルペノイドをリードとした抗がん剤耐性克服薬の創製研究–,
日本薬学会第128年会要旨集, 2008年3月.

(要約): -

阿部有里子, 柏田良樹, 高石喜久 :
青ジソ根部の有効利用に関する研究,
第46回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会要旨集, -, 2007年11月.

(要約): -

西村和也, 鎌倉孝法, 柏田良樹, 高石喜久, 柴田洋文, 樋口富彦 :
白コショウ(Piper nigrum)の成分研究,
第46回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会要旨集, 2007年11月.

(要約): -

橋田和佳, 田中直伸, 柏田良樹, 高石喜久 :
Hypericum ascyronの成分研究 (4),
第46回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会要旨集, 2007年11月.

(要約): -

中野達朗, 柴田洋文, 岡坂衛, 村上光太郎, 高石喜久, 樋口富彦 :
MRSAをはじめとする薬剤耐性菌に対する生薬由来の抗菌活性成分の探索,
第52回日本ブドウ球菌研究会要旨集, 2007年9月. 岡坂衛, 柴田洋文, 樋口富彦, 武田美雄, 伊藤美千穂, 本多義昭, Kozhimrov K. Olimjon, Ashurmetov Ozodbek, 高石喜久 :
ウズベキスタン産薬用植物Calligomum leucocladumより得られたアイルスマー(MRSAに対するβ-ラクタム剤感受性増強薬)について,
第52回日本ブドウ球菌研究会要旨集, 2007年9月. 柏田良樹, 高石喜久, 柴田洋文, 樋口富彦, 黒川昌彦 :
エラグ酸誘導体の抗MRSA活性及び抗HSV活性,
第52回日本ブドウ球菌研究会要旨集, 2007年9月.

(要約): -

柏田良樹, 柴田洋文, 樋口富彦, 高石喜久 :
エラグ酸誘導体の抗菌活性について,
日本生薬学会第54年会, 2007年9月. 橋田和佳, 田中直伸, 柏田良樹, 高石喜久 :
Hypericum ascyronの成分研究(3),
日本生薬学会第54年会, 2007年9月. 鈴木恭子, 岡坂衛, 柏田良樹, 高石喜久, Kodzhimatov K. Olimjon, Ashurmetov Ozodbek, 本多義昭, 伊藤美千穂 :
ウズベキスタン産薬用植物Ferula variaの成分研究(2),
日本生薬学会第54年会, 2007年9月. 金尚永, 柏田良樹, 高石喜久, 川添和義, 村上光太郎, 李順林 :
Chloranthus spicataの成分研究,
日本生薬学会第54年会, 2007年9月. 佐藤昌俊, 田中直伸, 柏田良樹, 高石喜久 :
桃花の成分研究,
薬学会第127年会, 2007年3月. 金尚永, Freddy Ramos, 廣野誠, 柏田良樹, 高石喜久, O.K. Kodzhimatov, Ozodbek Ashurmetov :
Inula helenium の成分研究,
日本薬学会第127年会, 2007年3月. 石田俊介, 岡坂衛, 柏田良樹, 高石喜久, O.K. Kodzhimatov, Ozodbek Ashurmetov :
Ziziphora pedicellataの成分研究,
日本薬学会第127年会, 2007年3月. 鎌倉孝法, 越智俊政, 柏田良樹, 高石喜久, 柴田洋文, 樋口富彦 :
メースMyristica fragrans)の成分研究,
日本薬学会第127年会, 2007年3月. 田中直伸, 柏田良樹, 高石喜久, 関田倫子, 池城安正 :
タカネオトギリ(hypericum sikokumontanum)より得たchromone glycosideについて,
日本薬学会第127年会, 2007年3月. 橋田和佳, 田中直伸, 柏田良樹, 高石喜久, 関田倫子, 池城安正 :
トモエソウHypericum ascyron)より得た細胞毒性を有するphloroglucinol誘導体及びxanthone誘導体について,
日本薬学会第127年会, 2007年3月. 岡坂衛, 柏田良樹, 高石喜久, O.K. Kodzhimatov, Ozodbek Ashurmetov :
ウズベキスタン薬用植物Mediasia macrophyllaの成分研究,
日本薬学会第127年会, 2007年3月. 柏田良樹, 高石喜久, Kilgore R. Nicole, Wild T. Carl, Allaway P. Graham, Lee Kuo-Hsiung :
抗HIV天然物に関する研究(20)-3-O-Glutaryl-betulin及び-dihydrobetulin ester誘導体の抗HIV活性―,
日本薬学会第127年会, 2007年3月. 川添和義, 柴田洋文, 樋口富彦, 高石喜久 :
植物に新しい抗MRSA薬を求めて,
日本化学会西日本大会, 265, 2006年11月. 柏田良樹, 関谷倫子, 池城安正, 山岸喬, 高石喜久 :
シラカバ花穂含有トリテルペンの多剤耐性腫瘍細胞に対する回復作用とp-糖蛋白に及ぼす影響,
第16回天然薬物の開発と応用シンポジウム, 2006年11月. 岡坂衛, 石田俊介, 鈴木恭子, 柏田良樹, 高石喜久, 関谷倫子, 池城安正, 伊藤美千穂, 本多義昭, 武田美雄, O.K. Khodzhimatov, O.A. Ashurmetov :
ウズベキスタン産薬用植物の成分と活性に関する研究,
第16回天然薬物の開発と応用シンポジウム, 2006年11月. 田中直伸, 中川博之, 橋田和佳, 佐藤昌俊, 奥瀬由惟, 田岡千明, 岩永智史, 土屋浩一郎, 高石喜久 :
スダチCitrus sudachi)の含有成分並びに血糖値上昇抑制作用について,
第一回食品薬学シンポジウム, 2006年10月. 東満美, 木原勝, 樋口富彦, 高石喜久, 山内卓 :
徳島大学における早期体験学習導入とその評価,
第16回日本医療薬学会年会, 2006年9月. 柏田良樹, 高石喜久, 江口達也, 関谷倫子, 池城安正 :
Moringa(Moringa oleifera)葉の成分に関する研究(5)-α-glucosideを有するフエノール配糖体についてー,
日本生薬学会第53回年会, 2006年9月. 田中直伸, 高石喜久 :
タカネオトギリ(Hypericum sikokumontanumの成分研究,
日本生薬学会第53回年会, 2006年9月. 橋田和佳, 田中直伸, 柏田良樹, 高石喜久, 関谷倫子, 池城安正 :
トモエソウHypericum ascyron)より得た新規phloroglucinol誘導体の構造と細胞毒性について,
日本生薬学会第53回年会, 2006年9月. 橋田千佳, 田中直伸, 柏田良樹, 高石喜久 :
コゴメバオトギリより得られたhyperforinの類似化合物の構造について,
日本生薬学会第53回年会, 2006年9月. 岡坂衛, 柏田良樹, 高石喜久, O. K. Kodzhimatov, Ozodbek Ashurmetov :
ウズベキスタン薬用植物Paeonia hybridaの成分研究,
日本生薬学会第53回年会, 2006年9月. 鈴木恭子, 岡坂衛, 高石喜久, O.K. Kodzhimatov, Ozodbek Ashurmetov, 本多義昭, 伊藤美千穂 :
ウズベキスタン産薬用植物Ferula variaの成分研究,
日本生薬学会第53回年会, 2006年9月. 石田俊介, 岡坂衛, Ferddy Ramos, 柏田良樹, 高石喜久, O. K. Kodzhimatov, Ozodbek Ashurmetov :
ウズベキスタン産薬用植物Condonopsis clematideaの成分研究,
日本生薬学会第53回年会, 2006年9月. 佐藤昌俊, 田中直伸, Ferddy Ramos, 柏田良樹, 高石喜久 :
桃花の成分研究,
日本生薬学会第53回年会, 2006年9月. 武田美雄, 友成麻岐, 有本志帆子, 増田俊哉, 本多義昭, 伊藤美千穂, 高石喜久, 大塚英昭, 松浪勝義, 木内文之 :
ウズベキスタン産伝統薬物Origanum tyttanthumの成分研究,
日本生薬学会第53回年会, 2006年9月. 柴田洋文, 近藤京子, 川添和義, 高石喜久, 長尾善光, 樋口富彦 :
MRSAに対するオクチルガレートの抗菌・抗アイルスマー活性に及ぼす金属イオンの影響,
第51回日本ブドウ球菌研究会, 2006年9月. 福井裕行, 川添和義, 高石喜久 :
鼻過敏症モデルラット鼻粘膜におけるアレルギーサイトカイン遺伝子発現亢進に対する和漢薬の抑制作用,
第23回和漢医薬学会大会, 2006年8月. 田中直伸, 高石喜久 :
ビョウヤナギの成分研究,
日本薬学会第126年会, 2006年3月. 鎌倉孝法, 越智俊政, 高石喜久, 柴田洋文, 樋口富彦 :
メース(Myristica fragrans)の成分研究,
日本薬学会第126年会, 2006年3月. 吉峰絵里, 川添和義, 高石喜久, Freddy Ramos, Xiaojiang Hao, 謝立山, 李順林, Diana Sinuco :
糯米香草(Semnostachya menglaensis)の成分研究,
日本薬学会第126年会, 2006年3月. 江口奈穂子, 柴田洋文, 近藤京子, 荒井勉, 塔本香奈, 友石章夫, 川添和義, 高石喜久, 堀内義史, 樋口雅紀, 樋口富彦 :
アイルスマー(MRSAに対するβ-ラクタム剤感受性増強薬)の創製,
第44回日本薬学会・日本病院薬剤師会中国四国支部学術大会, 84, 2005年11月. 鈴木恭子, 岡坂衛, 高石喜久, O. K. Kodzhimatov :
ウズベキスタン産薬用植物Ferula variaの成分研究,
第44回日本薬学会・日本病院薬剤師会中国四国支部学術大会, 2005年11月. 岡坂衛, 高石喜久, O. K. Kodzhimatov :
ウズベキスタン産薬用植物Paeonia hybrideの成分研究,
第44回日本薬学会・日本病院薬剤師会中国四国支部学術大会, 2005年11月. 釜屋久美子, 川添和義, 村上光太郎, 高石喜久, Xiajoiang Hao, 謝立山, 李順林 :
中国雲南省の民間薬通血香(Euodia lepta)の成分研究,
第44回日本薬学会・日本病院薬剤師会中国四国支部学術大会, 2005年11月. 橋田千佳, 田中直伸, 高石喜久 :
コゴメバオトギリ (Hypericum perforatum var. angustifolium)の成分研究,
第44回日本薬学会・日本病院薬剤師会中国四国支部学術大会, 2005年11月. 田中直伸, 高石喜久 :
ビョウヤナギ(Hypericum chinense)の成分研究,
第44回日本薬学会・日本病院薬剤師会中国四国支部学術大会, 2005年11月. 田中直伸, 石丸陽子, 岡坂衛, 高石喜久, 武田美雄, 本多義昭, 伊藤三千穂, Kuo-Hsiung Lee :
オトギリソウ科Hypericum属に含まれる生理活性物質の探索,
第47回天然有機化合物討論会, Vol.P61, 413-418, 2005年10月. 岡坂衛, 高石喜久, Olimjon. K. Kodzhimatov, Ozodbek Ashurmetov :
ウズベキスタン産薬用植物Juniperus seravschanica Komarovの成分研究,
日本生薬学会第52年会, 2005年9月. F. Ramos, 高石喜久, 白鳥水紀, 川口陽佑 :
Quercetin oxidation derivatives from Onion(Allium cepa) skin,
日本生薬学会第52年会, 2005年9月. 福井裕行, 川添和義, 高石喜久 :
鼻過敏症モデルラットのヒスタミンH1受容体とヒスチジン脱炭酸酵素の遺伝子発現亢進とそれに対する和漢薬の抑制作用,
第22回和漢医薬学会大会, 2005年8月. 川添和義, 高石喜久, 村上光太郎, 岡坂衛, Hao Xiaojiang, 謝立山, 李順林 :
中国南部の少数民族薬調査(2) 雲南省西部の薬物,
日本薬学会第125年会, 128, 2005年3月. 田中直伸, 高石喜久 :
ビョウヤナギの成分研究,
日本薬学会第125年会, 2005年3月. 高石喜久, 川添和義, 村上光太郎 :
中国南部の少数民族薬調査(1) 雲南省東南部の薬物,
第43回日本薬学会・日本病院薬剤師会中国四国支部学術大会, 39, 2004年11月. 田畑麻美, 川添和義, 高石喜久 :
イソマツの成分研究,
第43回日本薬学会・日本病院薬剤師会中国四国支部学術大会, 30, 2004年11月. 堀長志帆, 吉村祥穂, 村田有希, 土屋浩一郎, 峰松敏彦, 川添和義, 高石喜久, 福井裕行 :
苦参，小青竜湯のアレルギー疾患関連遺伝子発現機構への影響,
第43回日本薬学会・日本病院薬剤師会中国四国支部学術大会, 2004年11月. 石上まみ, 池平しのぶ, 三好真紀, 土屋浩一郎, 滝口祥令, 高石喜久 :
竹粉末のロペラミン誘発便秘改善作用,
第43回日本薬学会・日本病院薬剤師会中国四国支部学術大会, 2004年11月. 田中直伸, 石丸陽子, 高石喜久 :
ビョウヤナギ(Hypericum chinense)の成分研究,
第43回日本薬学会・日本病院薬剤師会中国四国支部学術大会, 2004年11月. 駒木根希, 高石喜久 :
ウズベキスタン産薬用植物Rheum maximowicziiの成分研究,
第43回日本薬学会・日本病院薬剤師会中国四国支部学術大会, 2004年11月. 高石喜久, 川添和義, 村上光太郎, Xiajoiang Hao, 謝立山, 李順林 :
中国南部の少数民族薬物調査(1)雲南省東南部の薬物,
第43回日本薬学会・日本病院薬剤師会中国四国支部学術大会, 2004年11月. 高石喜久, 川添和義, 村上光太郎, Xiajoiang Hao, 謝立山, 李順林 :
雲南省東南部における少数民族薬物調査,
日本生薬学会第51年会, 2004年9月. 菅愛, 中川博之, 岩佐惟士, 川口陽佑, 高石喜久 :
(Myrica rubra)の成分研究,
日本生薬学会第51年会, 2004年9月. F Ramos, 高石喜久, C. Osorio, C. Que Du, R. Acuna, Y. Fujimoto :
New Polihydroxyacetylenes from Hydrocotyle leucocepala C. & S.,
日本生薬学会第51年会, 2004年9月. 田中直伸, 高石喜久, 武田美雄, 本多義昭, 伊藤美千穂 :
Hypericum scabrumの成分研究(2),
日本生薬学会第51年会, 2004年9月. 中川博之, 高石喜久, 藤本善徳 :
コロンビア産薬用植物Maytenus laevisの成分研究,
日本薬学会第124年会要旨集, 2004年3月. 越智俊政, 高石喜久 :
Capsinum annunm(ししとう)の成分研究,
日本薬学会第124年会要旨集, 2004年3月. 佐川貴昭, 高石喜久, 中川博之, 藤本善徳, Garzon Cristina, Osorio Coralia, Duque Carmebza, Ramos Freddy :
コロンビア産薬用植物Achyrocline bogotensisの成分研究,
日本薬学会第124年会要旨集, 2004年3月. 趙正容, 川添和義, 高石喜久, 文齋鶴, 朴根亭 :
ソバ果実中の抗菌性物質,
日本薬学会第124年会要旨集, 2004年3月. 高石喜久 :
天然薬物のフイールドワークを考える，シンポジウム24, --- 天然物科学からみた伝統薬物調査 ---,
日本薬学会第124年会要旨集, 2004年3月. 田中直伸, 敷島康普, 武田美雄, 本多義昭, 伊藤美千穂, 高石喜久 :
Hypericum scabrumの成分研究,
日本生薬学会第49回年会, 129, 2002年9月. 田中直伸, 近藤京子, 坪内良子, 高石喜久, 清水克英, 永澤秀子, 堀均 :
HCT116細胞を用いたin vitroスクリーニングによる抗腫瘍性天然物質の探索,
日本薬学会第122年会, 115, 2002年3月. 田中直伸, 段宏泉, 大庭信行, 敷島康普, 高石喜久 :
ニシキギ科コバノクロヅルの成分研究,
日本生薬学会第48回年会, 184, 2001年9月. 清水克英, 永澤秀子, 段宏泉, 高石喜久, 宇都義浩, 堀均 :
雷公藤(Triptergium wilfordii Hook F.)由来テルペノイドの抗腫瘍活性,
日本薬学会第121年会, 2001年3月.

(要約): 雷公藤(Triptergium wilfordii Hook F.)由来テルペノイドの抗腫瘍活性について報告した．

田中直伸, 段宏泉, 大庭信行, 高石喜久 :
ニシキギ科コバノクロヅルの成分研究,
日本薬学会中国四国支部学術大会, 78, 2000年10月.

研究会・報告書: 桐山聰, 英崇夫, 荒木秀夫, 中村浩一, 黒岩眞吾, 藤澤正一郎, 原口雅宣, 玉置俊晃, 羽地達次, 高石喜久, 來山征士, 大橋眞, 上田哲史 :
特色ある大学教育支援プログラム「進取の気風」を育む創造性教育の推進平成17年度報告書, --- 若者のセルフ·マネジメント能力を育てる徳島大学創成学習開発センターの活動 ---,
特色ある大学教育支援プログラム「進取の気風」を育む創造性教育の推進平成17年度報告書, 徳島, 2006年3月.

特許: 高石喜久, 土屋浩一郎 : 新規ポリフェノール化合物, 特願P2005-237783, 特開P2007-51099A, . 高石喜久, 土屋浩一郎 : 天然素材を有効に利用した組成物，並びに当該組成物を含有する医薬組成物，健康食品及びサプリメントを提供すること, 特願2006-2211171, 特開2007-77139, . Tomihiko Higuti, Hirofumi Shibata, Youichi Sato, Yoshihisa Takaishi, Kazuyoshi Kawazoe and Kotaro Murakami : Medical composition for treating infection with drugresistant Staphylococcus aureus, PIXXD2 WO 2004066992 A1 20040812 CAN 141:167738 AN 2004:648378 CAPLUS (Apr. 2004). 福井裕行, 高石喜久, 水口博之, 柏田良樹, 根本尚夫 : アレルギー疾患感受性遺伝子発現抑制物質, 特願2009-284069 (2009年12月), 特許第PCT/KR2010/008995号 (2009年12月). 高石喜久, 土屋浩一郎 : 新規NAD依存性脱アセチル化酵素活性化剤, 特願2007-301398 (2007年11月), 特開2009-126799 (2009年6月), . 川添和義, 高石喜久, 樋口富彦, 柴田洋文 : 抗MRSA薬剤, 特願2001-400259 (2001年12月), 特許第3979843号 (2007年7月).
作品: 研究者総覧に該当データはありませんでした。
補助金・競争的資金: 薬剤耐性 HIV 克服を目指した抗 HIV 薬の創製研究 (研究課題/領域番号: 22510233 )
モンゴル民族の伝統薬物調査とその有効利用に関する研究 (研究課題/領域番号: 22406024 )
中国雲南省少数民族の伝統薬物調査とその有効利用に関する研究(第二次) (研究課題/領域番号: 18406028 )
知的好奇心を深め科学的な思考力や科学技術を育む科目・分野横断的科学実験教材の開発 (研究課題/領域番号: 17011054 )
中国雲南省少数民族の伝統薬物調査とその有効利用に関する研究 (研究課題/領域番号: 15406032 )
トルコ系民族の伝統薬物に関する比較調査研究(3) (研究課題/領域番号: 15406003 )
南米コロンビアの伝統薬物の評価・開発に関する研究 (研究課題/領域番号: 12576030 )
トルコ系民族の伝統薬物に関する比較調査研究(2) (研究課題/領域番号: 12576027 )
新規リウマチ治療薬の開発をめざした雷公藤製剤TIIの成分研究 (研究課題/領域番号: 10557209 )
フリーラジカルを介して作用する新規抗マラリア薬の開発研究 (研究課題/領域番号: 09270219 )
トルコ系民族の伝統薬物に関する比較調査研究 (研究課題/領域番号: 09041182 )
チロシンカイネース阻害作用に基づく新しいタイプの抗リュウマチ薬の開発研究 (研究課題/領域番号: 08557136 )
トルコの薬用植物資源に関する調査研究 (研究課題/領域番号: 06041069 )
ベンゾジアゼピン受容体アゴニスト活性を有するノルジテルペンの合成研究 (研究課題/領域番号: 05680507 )
新しい作用機序に基づく慢性関節リウマチ治療薬の開発研究 (研究課題/領域番号: 05558082 )
ニシキギ科植物に含まれる低毒性抗発がんプロモーター作用物質に関する研究 (研究課題/領域番号: 05453183 )
トルコの伝統薬物と薬用植物資源に関する調査研究 (研究課題/領域番号: 02041048 )
腹菌類の成分研究 (研究課題/領域番号: 63570994 )
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専門分野・研究分野: 生薬学 (Pharmacognosy)
天然物化学 (Natural Products Chemistry)
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Jグローバル最終確認日: 2024/5/4 01:24
氏名（漢字）: 高石喜久
氏名（フリガナ）: タカイシヨシヒサ
氏名（英字）: Takaishi Yoshihisa
所属機関: 徳島大学教授

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researchmap最終確認日: 2024/5/5 01:39
氏名（漢字）: 高石喜久
氏名（フリガナ）: タカイシヨシヒサ
氏名（英字）: Takaishi Yoshihisa
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登録日時: 2010/7/21 00:00
更新日時: 2022/8/14 10:22
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所属ID: 0344012002
所属: 徳島大学
部署: 薬学部創製薬科学科
職名: 教授
学位: 薬学博士
学位授与機関: 京都大学
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研究者番号: 60035558

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所属（過去の研究課題 情報に基づく）*注記: 2012/4/1 : 徳島大学, 大学院・へルスバイオサイエンス研究部, 教授
2010/4/1 – 2012/4/1 : 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授
2004/4/1 – 2008/4/1 : 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授
2005/4/1 – 2006/4/1 : 徳島大学, 大学院ヘルスバイオサイエンス研究部, 教授
1992/4/1 – 2003/4/1 : 徳島大学, 薬学部, 教授
1988/4/1 – 1991/4/1 : 徳島大学, 薬学部, 助教授

審査区分/研究分野

研究代表者

生物系 / 医歯薬学 / 内科系臨床医学 / 内科学一般(含心身医学)
医学 / 薬学 / 化学系薬学
複合領域 / 生物化学 / 生物有機科学
医学 / 薬学 / 医薬分子機能学

研究代表者以外

複合領域 / 生物化学 / 生物有機科学
生物系 / 医歯薬学 / 内科系臨床医学 / 内科学一般(含心身医学)
総合・新領域系 / 複合新領域 / 生体分子科学 / 生物分子科学
医学 / 薬学 / 化学系薬学
生物系 / 医歯薬学 / 薬学 / 化学系薬学
人文・社会系

キーワード

研究代表者

伝承医薬 / 民間医療 / 少数民族薬物 / 天然物化学 / 伝統薬物調査 / 雲南省 / 伝承薬物 / 民間薬 / 生薬学 / 伝承医薬品 / 中国雲南省 / がん / 抗発がんプロモーター / セスキテルペン / ウイルス / ニシキギ科 / クロズル / マウス皮膚二段階発がん / スチルベン / トリテルペン / 植物成分 / 植物組織培養 / sesquiterpene / antitumor promoter / Celastraceae / Tripterygium / two-stage carcinogenic test / Triptogelin / triptofordin / TPA / リウマチ / インターロイキン-1 / トリプトキノン / 一酸化窒素 / ジテルペン / キノイド / カルス / 慢性関節リウマチ / 抗炎症 / rheumatoid arthritis / interleukin-1 / triptoquinone / diterpene / quinoide / NO / callus / 血管平滑筋 / リュウマチ / 酵素誘導 / カルシウム / 血管内皮 / チロシンキナーゼ / メッセンジャーRNA / Vascular smooth muscle / Rheumatoid arthritis / Trip toquinone / Nitric oxide / Enzyme induction / Calcium / Endothelium / Tyrosine kinase / インターロイキン / 天然物 / 雷公藤 / 電公藤 / アルカロイド / 毛状根培養 / RHEUMATOID ARTHRITIS / CYTOKINE / Tripterygium wilfordii / Triterpene / Diterpene / Interleukin-1 / Natural Product / 中国 / traditional medicine / folk medicine / raw material / drug of minority group / pharmacognosy / natural products chemistry / survey of traditional medicine / Yunnan Province, China / 担子菌 / 腹菌類 / ステロイド / ツチグリ / コツブタケ / オニフスベ / ノウタケ / calvatic acid / Traditional medicine / Higher fungi / Gasteromycete / Astraeus hygrometricus / Pisolithus tinctoricus / Steroid / Lasiosphaera nipponica / Calvatia ramiformis

研究代表者以外

ベンゾジアゼピン / アゴニスト / 向神経薬 / 分子内付加環化 / ノルジテルペン / タンシノン / フラン / キノン / 抗マラリア薬 / フリーラジカル / 抗マラリア活性機構 / 構造活性相関 / アルテミシニン関連化合物 / ヒガンバナ科アルカロイド / ESRスペクトル / 科目・分野横断的科学実験教材 / 連携協力の教育体系や枠組みの構築 / 構造解析 / 情報教育 / 遠隔教育教材 / 簡易比色計・蛍光光度計・反射率計の組み立て / 実践教育 / 染色科学 / 簡易比色計の組み立て / モンゴル民族 / 伝統薬物 / 薬用資源 / 国際情報交換 / モンゴル / 民族薬物 / AIDS / 薬剤耐性 / トリテルペン / ベツリン / トルコ / 薬用植物 / 遺伝子源 / カンゾウ / 成分分析 / 薬理活性 / 薬種商 / Turkey / traditional medicine / medicinal plants / licorice / chemical analysis / pharmacological activity / gene resources / トルコ族 / ウズベキスタン / 薬用植物日秘 / Turkic People / Folk Medicine / Republic of Uzbekistan / Medicinal Plants / 中央アジア / トルコ系民族 / 天然物化学 / 甘草 / フィールドワーク / カブフスタン / カザフスタン / CENTRAL ASIA / TURKIC PEOPLE / TRADITIONAL MEDICINES / MEDICINAL PLANTS / PHYTOCHEMISTRY / LICORICE / 国際研究者交流 / コロンビア / 生理活性物質 / 生物活性 / Mikania glomerata / Hydrocotyle umbellata / Campomanesia lineatifolia / Inga spectabilis / Niphogeton ternata / Sicana odorifera / Maytenus krukovit / Anacardium giganteum / Cedrela odorata / Aplum ternata / Erynglum foetidum / Anacrdium giganteum / Spondias purpurea / International Exchange of Researchers / Colombia / Medicinal Plant / Natural product chemistry / Bioactive substances / イラン / 新疆 / ウズベク:カザフ:新彊 / 民間伝承薬物 / 成分研究 / 生理活性 / Turkic people / Medicinal Resources / Traditional Medicines / Uzbekistan / Iran / China-Shinjan / Fieldwork

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高石 喜久

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高石喜久