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大豆本圭

徳島大学

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2024年12月23日更新

職名: 助教
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学位: 博士(医学)
職歴・経歴: 2019/4: 徳島大学特任助教, 病院 (-2020.3.)
2020/4: 徳島大学助教, 大学院医歯薬学研究部

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2024年12月23日更新

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担当経験のある授業科目: 泌尿器科学(隣接医学B) (学部)
腎・尿路・男性生殖器コース (学部)
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2024年12月23日更新

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著書

山本恭代, 大豆本圭, 楠原義人, 森英恭, 布川朋也, 山口邦久, 福森知治, 高橋正幸, 金山博臣 :
膀胱への穿通胎盤にて帝王切開，子宮全摘，膀胱部分切除術施行後に骨盤内尿腫を形成し，真性尿失禁をきたした1例,
2018年10月.

論文

Kazuyoshi Noda, Yasushi Sato, Yasuyuki Okada, Kensei Nishida, Yutaka Kawano, Toshihito Tanahashi, Masahiro Bando, Koichi Okamoto, Masanori Takehara, Masahiro Sogabe, Hiroshi Miyamoto, Kei Daizumoto, Hiro-omi Kanayama and Tetsuji Takayama :
Exosomal miR-199a-3p Secreted From Cancer-Associated Adipocytes Promotes Pancreatic Cancer Progression.,
Cancer Medicine, Vol.13, No.20, e70265, 2024.

(要約): Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer. Recent studies indicated that cancer-associated adipocytes (CAAs) play crucial roles in tumor progression; however, the precise mechanism remains unknown. Here, we analyzed specific exosomal microRNAs (miRNA) signatures derived from pancreatic CAAs to investigate their role in cancer progression. CAAs were generated by co-culturing human adipocytes with human pancreatic cancer cells, and exosomes were isolated from the CAA-conditioned medium (CAA-CM). Small RNA-seq analysis was used to identify differentially expressed miRNAs in these exosomes. The effects of miRNAs on cell proliferation, migration/invasion, and drug sensitivity were examined. Luciferase reporter assays, real-time polymerase chain reaction, and western blotting were performed to investigate the molecular mechanisms of the miRNAs. The clinical relevance of the miRNAs was investigated using publicly available data and our cohort of patients with PDAC. miR-199a-3p expression was significantly increased in CAA-CM-derived exosomes. CAA-derived exosomes transferred miR-199a-3p to pancreatic cancer cells. Transfection with miR-199a-3p increased the proliferation, invasion, migration, and drug resistance of pancreatic cancer cells by downregulating SOCS7, increasing STAT3 phosphorylation, and upregulating SAA1 expression. High tissue miR-199a-3p expression is correlated with poor prognosis in patients with PDAC. Liquid biopsies revealed that exosomal miR-199a-3p could accurately differentiate patients with PDAC from healthy controls. Multivariate survival analysis indicated that miR-199a is an independent prognostic factor for PDAC. miR-199a-3p in CAA-derived exosomes contributes to the malignant transformation of pancreatic cancer via the SOCS7/STAT3/SAA1 pathway, suggesting its potential as a biomarker and therapeutic target for PDAC.
(キーワード): Humans / MicroRNAs / Exosomes / Pancreatic Neoplasms / Disease Progression / Cell Proliferation / Carcinoma, Pancreatic Ductal / Adipocytes / Cell Line, Tumor / Gene Expression Regulation, Neoplastic / Cell Movement / STAT3 Transcription Factor / Prognosis / Biomarkers, Tumor / Female / Male / Drug Resistance, Neoplasm
(出版サイトへのリンク): ● Publication site (DOI): 10.1002/cam4.70265
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 39431622; ● Search Scopus @ Elsevier (PMID): 39431622; ● Search Scopus @ Elsevier (DOI): 10.1002/cam4.70265

(DOI: 10.1002/cam4.70265, PubMed: 39431622) Yutaro Sasaki, Yoshito Kusuhara, Takuro Oyama, Mitsuki Nishiyama, Saki Kobayashi, Kei Daizumoto, Ryotaro Tomida, Yoshiteru Ueno, Tomoya Fukawa, Kunihisa Yamaguchi, Yasuyo Yamamoto, Masayuki Takahashi, Hiroomi Kanayama and Junya Furukawa :
Radical prostatectomy using the Hinotori robot-assisted surgical system: Docking-free design may contribute to reduction in postoperative pain.,
The International Journal of Medical Robotics + Computer Assisted Surgery : MRCAS, Vol.20, No.3, e2648, 2024.

(要約): The docking-free design of the Japanese Hinotori surgical robotic system allows the robotic arm to avoid trocar grasping, thereby minimising excessive abdominal wall stress. The aim of this study was to evaluate the safety and efficacy of robotic-assisted radical prostatectomy (RARP) using the Hinotori system and to explore the potential contribution of its docking-free design to postoperative pain reduction. This study reviewed the clinical records of 94 patients who underwent RARP: 48 patients in the Hinotori group and 46 in the da Vinci Xi group. Hinotori group had significantly longer operative and console times (p = 0.030 and p = 0.029, respectively). Perioperative complications and oncologic outcomes did not differ between the two groups. On postoperative day 4, the rate of decline from the maximum visual analogue scale score was marginally significant in the Hinotori group (p = 0.062). The docking-free design may contribute to reducing postoperative pain.
(キーワード): Humans / Prostatectomy / Robotic Surgical Procedures / Male / Pain, Postoperative / Middle Aged / Aged / Prostatic Neoplasms / Treatment Outcome / Retrospective Studies / Operative Time
(出版サイトへのリンク): ● Publication site (DOI): 10.1002/rcs.2648
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38824454; ● Summary page in Scopus @ Elsevier: 2-s2.0-85195016810

(DOI: 10.1002/rcs.2648, PubMed: 38824454, Elsevier: Scopus) Yutaro Sasaki, Katsuhito Hori, Kei Daizumoto, Yoshito Kusuhara, Tomoya Fukawa and Masayuki Takahashi :
A new trick for scrotal surgery using Doyen intestinal forceps.,
International Journal of Urology, Vol.31, No.4, 446-447, 2024.

(キーワード): Humans / Anastomosis, Surgical / Surgical Instruments
(出版サイトへのリンク): ● Publication site (DOI): 10.1111/iju.15366
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38116859; ● Summary page in Scopus @ Elsevier: 2-s2.0-85180170927

(DOI: 10.1111/iju.15366, PubMed: 38116859, Elsevier: Scopus) Fumiya Kadoriku, Yutaro Sasaki, Kyotaro Fukuta, Mitsuki Nishiyama, Seiya Utsunomiya, Saki Kobayashi, Keito Shiozaki, Kei Daizumoto, Yoshiteru Ueno, Kosuke Seto, Ryotaro Tomida, Yoshito Kusuhara, Tomoya Fukawa, Ryoichi Nakanishi, Kunihisa Yamaguchi, Yasuyo Yamamoto, Hirofumi Izaki, Masayuki Takahashi and Junya Furukawa :
Robot-assisted intracorporeal ileal conduit urinary diversion: A two-center comparative study of Bricker versus Wallace ureteroileal anastomosis,
Asian Journal of Endoscopic Surgery, Vol.17, No.2, e13307, 2024.

(要約): This study was performed to evaluate the differences in the perioperative results, renal function, and incidence of hydronephrosis over time between the use of Bricker anastomosis and Wallace anastomosis for robot-assisted intracorporeal ileal conduit urinary diversion (RICIC). Fifty-five patients who underwent RICIC at two institutions were evaluated (Bricker, n = 23; Wallace, n = 32). We investigated changes in estimated glomerular filtration rate and hydronephrosis before surgery and at 3, 6, and 12 months after surgery. The patients in the Bricker group were significantly older than those in the Wallace group. The urinary diversion time was significantly longer in the Bricker group. No significant difference in postoperative renal function was observed. Additionally, no significant difference was observed in the incidence of postoperative hydronephrosis. However, the incidence of right hydronephrosis tended to be high overall, especially in the Wallace group. No patients in either group required repair surgery or ureteral stent placement. In patients undergoing RICIC, there was no difference in postoperative renal function or the incidence of hydronephrosis between Wallace and Bricker anastomosis. Symptomatic hydronephrosis was not observed in either group. The present study showed that each method was equally effective and safe.
(キーワード): Humans / Robotics / Ileum / Urinary Diversion / Cystectomy / Hydronephrosis / Anastomosis, Surgical / Urinary Bladder Neoplasms
(出版サイトへのリンク): ● Publication site (DOI): 10.1111/ases.13307
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38561598; ● Summary page in Scopus @ Elsevier: 2-s2.0-85189310851

(DOI: 10.1111/ases.13307, PubMed: 38561598, Elsevier: Scopus) Yutaro Sasaki, Kazuyoshi Izumi, Kyotaro Fukuta, Fumiya Kadoriku, Yuichiro Atagi, Kei Daizumoto, Keito Shiozaki, Ryotaro Tomida, Yoshito Kusuhara, Tomoya Fukawa, Yutaka Yanagihara, Kunihisa Yamaguchi, Yasuyo Yamamoto, Hirofumi Izaki, Masayuki Takahashi, Kenjiro Okamoto, Masahito Yamanaka and Junya Furukawa :
Impact of lymph node dissection on surgical and oncological outcomes in patients undergoing robot-assisted radical cystectomy for bladder cancer: a multicenter retrospective study,
Journal of Robotic Surgery, Vol.18, No.1, 141, 2024.

(要約): This study was performed to clarify the therapeutic and diagnostic roles of lymph node dissection (LND) by examining the impact of LND and lymph node yield (LNY) on oncological outcomes in patients undergoing robot-assisted radical cystectomy (RARC). Between 2014 and 2021, 216 patients underwent LND during RARC at Tokushima University Hospital and affiliated hospitals. Among the 216 patients, we compared 115 patients with an LNY of ≥ 20 and 101 with an LNY of < 20 to investigate the impact of LNY on surgical and oncological outcomes. Furthermore, we investigated the impact of LNY and the extent of LND on oncological outcomes by dividing the extent of LND into two groups (standard and extended). The 3-year rates of overall survival (OS) (p = 0.256), cancer-specific survival (CSS) (p = 0.791), and recurrence-free survival (RFS) (p = 0.953) did not differ between the two groups divided by the LNY. A higher LNY was associated with a significantly higher lymph node positivity rate (p = 0.020). The incidence of LND-related major complications was not significantly different between the two groups (p = 0.910). The 3-year survival rates did not differ between the two groups divided by the extent of LND: OS (p = 0.366), CSS (p = 0.814), and RFS (p = 0.689). The LNY and extent of LND were not associated with oncological outcomes in patients undergoing LND during RARC, whereas a higher LNY was associated with lymph node positivity. In the era of adjuvant therapy with immune checkpoint inhibitors, LND during RARC has an important diagnostic role in the detection of pathological node positivity.
(キーワード): Humans / Cystectomy / Lymph Node Excision / Retrospective Studies / Robotic Surgical Procedures / Treatment Outcome / Urinary Bladder Neoplasms
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s11701-024-01893-y
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38554230; ● Summary page in Scopus @ Elsevier: 2-s2.0-85188969651

(DOI: 10.1007/s11701-024-01893-y, PubMed: 38554230, Elsevier: Scopus) Yutaro Sasaki, Masayuki Takahashi, Keito Shiozaki, Katsuhito Hori, Fumiya Kadoriku, Kei Daizumoto, Ryotaro Tomida, Yoshiteru Ueno, Yoshito Kusuhara, Tomoya Fukawa, Kunihisa Yamaguchi, Yasuyo Yamamoto, Koichi Tomita, Koichi Sairyo and Hiroomi Kanayama :
The importance of laparoscopic surgery for young urologists remains unwavering even in the era of robot assisted surgery,
Asian Journal of Endoscopic Surgery, Vol.17, No.1, e13254, 2023.

(要約): Robot-assisted surgery (RAS) cannot be achieved without the performance of laparoscopic surgical techniques by a patient-side surgeon (PSS). In many medical institutions in Japan, young urologists often take on the role of a PSS. Participating in RAS as a PSS provides a good opportunity to acquire not only the knowledge necessary for surgery, but also skills in laparoscopic surgical techniques. Learning laparoscopic surgery as a PSS may contribute to improving the quality of RAS. Furthermore, it will lead to skill improvement as an operator in laparoscopic surgery. However, notably, opportunities for young urologists to perform laparoscopic surgery are decreasing in the current era of RAS. Under these circumstances, we believe that cadaver surgical training will become increasingly important in the future. We believe that performance of cadaver surgical training will contribute to increased motivation, enhance the understanding of surgical procedures, and facilitate the acquisition of surgical techniques.
(キーワード): Humans / Robotic Surgical Procedures / Urologists / Laparoscopy / Clinical Competence / Cadaver
(出版サイトへのリンク): ● Publication site (DOI): 10.1111/ases.13254
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37837342; ● Summary page in Scopus @ Elsevier: 2-s2.0-85173987092

(DOI: 10.1111/ases.13254, PubMed: 37837342, Elsevier: Scopus) Yoichiro Tohi, Takuma Kato, Keita Kobayashi, Kei Daizumoto, Hideo Fukuhara, Shin Ohira, Satoshi Katayama, Ryutaro Shimizu, Atsushi Takamoto, Kenichi Nishimura, Kenichiro Ikeda, Taichi Nagami, Yushi Hayashida, Hiromi Hirama, Hirohito Naito, Ryotaro Tomida, Yutaro Sasaki, Shinkuro Yamamoto, Shinjiro Shimizu and Mikio Sugimoto :
Real-world prostate-specific antigen response and progression to castration-resistant prostate cancer among men with metastatic castration-sensitive prostate cancer treated with apalutamide: a multi-institutional study in the Chu-shikoku Japan Urological Consortium.,
Japanese Journal of Clinical Oncology, Vol.54, No.2, 167-174, 2023.

(要約): Japanese men receiving apalutamide often experience skin-adverse events (AEs), possibly requiring treatment interruption or dose reduction. However, concerns have arisen regarding the impact of these adjustments on the efficacy of apalutamide. Our study evaluated the efficacy, safety, and persistence of apalutamide in men with metastatic castration-sensitive prostate cancer (mCSPC). We retrospectively reviewed the medical records of 108 men with mCSPC from 14 Japanese institutions. The primary outcomes were the efficacy of apalutamide: prostate-specific antigen (PSA) response (50%, 90% and < 0.2 decline) and progression to castration-resistant prostate cancer (CRPC). The secondary outcomes were the skin-AE and compliance of apalutamide. PSA50%, PSA90% and PSA < 0.2 declines were observed in 89.8, 84.3 and 65.7%, and the median time to CRPC progression was not reached. PSA < 0.2 decline and an initial full dose of apalutamide were significantly associated with a longer time to CRPC. The most common AE was skin-AE (50.9%), and there was no association between the occurrence of skin-AE and the time to CRPC (P = 0.72). The median apalutamide persistence was 29 months, which was longer in the initial full dose recipients than in the reduced dose recipients. The dosage is reduced in about 60% of patients within the first year of treatment in the initial full dose recipients. Our findings indicate the effectiveness of apalutamide in Japanese men with mCSPC, despite a substantial portion requiring dose reduction within a year among the initial full dose recipients.
(キーワード): 男性 (male) / Humans / Prostate-Specific Antigen / Prostatic Neoplasms, Castration-Resistant / 日本 (Japan) / Retrospective Studies / Castration / Thiohydantoins
(出版サイトへのリンク): ● Publication site (DOI): 10.1093/jjco/hyad143
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37840362; ● Summary page in Scopus @ Elsevier: 2-s2.0-85184522620

(DOI: 10.1093/jjco/hyad143, PubMed: 37840362, Elsevier: Scopus) Yoshito Kusuhara, Tomoya Fukawa, Tomoharu Fukumori, Yoshiteru Ueno, Kei Daizumoto, Yutaro Sasaki, Ryotaro Tomida, Yasuyo Yamamoto, Kunihisa Yamaguchi, Chisato Tonoiso, Akiko Kubo, Takashi Kawanaka, Shunsuke Furutani, Hitoshi Ikushima, Hiro-omi Kanayama and Masayuki Takahashi :
Effect of Positive Biopsy Core Rate on Low-dose-rate Brachytherapy Outcomes in Intermediate-risk Prostate Cancer.,
Anticancer Research, Vol.43, No.10, 4627-4635, 2023.

(要約): Positive core ratios observed on prostate biopsy correlated with higher recurrence rates after LDR-BT. This indicates that the proportion of positive cores in the biopsy may be an important factor in predicting the likelihood of recurrence, especially for patients with GG3 PCa.
(キーワード): Male / Humans / Retrospective Studies / Brachytherapy / Prostatic Neoplasms / Neoplasm Grading / Biopsy / Prostate-Specific Antigen
(出版サイトへのリンク): ● Publication site (DOI): 10.21873/anticanres.16657
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37772553; ● Search Scopus @ Elsevier (PMID): 37772553; ● Search Scopus @ Elsevier (DOI): 10.21873/anticanres.16657

(DOI: 10.21873/anticanres.16657, PubMed: 37772553) Yutaro Sasaki, Masayuki Takahashi, Kei Daizumoto, Keito Shiozaki, Tomoya Fukawa and Hiroomi Kanayama :
Assistent guide short: A new device for facilitating ureteric stenting in women.,
International Journal of Urology, 2023.

(出版サイトへのリンク): ● Publication site (DOI): 10.1111/iju.15252
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37504506; ● Summary page in Scopus @ Elsevier: 2-s2.0-85165960914

(DOI: 10.1111/iju.15252, PubMed: 37504506, Elsevier: Scopus) Yutaro Sasaki, Kei Daizumoto, Kyotaro Fukuta, Keito Shiozaki, Mitsuki Nishiyama, Seiya Utsunomiya, Saki Kobayashi, Kosuke Seto, Yoshiteru Ueno, Ryotaro Tomida, Yoshito Kusuhara, Tomoya Fukawa, Ryoichi Nakanishi, Kunihisa Yamaguchi, Yasuyo Yamamoto, Hirofumi Izaki and Masayuki Takahashi :
Lymph node dissection during radical cystectomy for bladder cancer: A two-center comparative study of robotic versus open surgery.,
Asian Journal of Endoscopic Surgery, 2023.

(要約): This study was performed to evaluate the safety and efficacy of lymph node dissection (LND) during robot-assisted radical cystectomy (RARC) compared with open radical cystectomy (ORC). From October 2003 to December 2021, 122 patients underwent LND during RARC and 103 patients underwent LND during ORC at Tokushima University Hospital and Tokushima Prefectural Central Hospital. We investigated the safety and efficacy of LND during RARC by comparing the surgical and oncological outcomes between the two groups. The patients were significantly older in the RARC than the ORC group. The operative time was significantly shorter and the estimated blood loss was significantly lower in the RARC than the ORC group. Although the lymph node yield was significantly higher in the RARC than the ORC group, there was no significant difference in lymph node positivity between the groups. There was no significant difference in the incidence of local recurrence or distant metastasis between the two groups. The 5-year survival rates (overall survival, cancer-specific survival, and recurrence-free survival) were not different between the RARC and ORC groups. This study suggests that the surgical and oncological safety and efficacy of LND during RARC are greater than those of LND during ORC. We believe that LND during RARC is a higher-quality procedure than LND during ORC.
(出版サイトへのリンク): ● Publication site (DOI): 10.1111/ases.13234
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37489628; ● Summary page in Scopus @ Elsevier: 2-s2.0-85165549223

(DOI: 10.1111/ases.13234, PubMed: 37489628, Elsevier: Scopus) Masayuki Takahashi, Kei Daizumoto, Tomoya Fukawa, Yayoi Fukuhara, Yoshimi Bando, Minoru Kowada, Tsogt-Ochir Dondoo, Yutaro Sasaki, Ryotaro Tomida, Yoshiteru Ueno, Megumi Tsuda, Yoshito Kusuhara, Kunihisa Yamaguchi, Yasuyo Yamamoto, Hisanori Uehara and Hiroomi Kanayama :
Insulin receptor expression to predict resistance to axitinib and elucidation of the underlying molecular mechanism in metastatic renal cell carcinoma.,
British Journal of Cancer, 2023.

(要約): Decreased INSR in RCC could be a biomarker to predict axitinib resistance. Regarding the resistant mechanism, vascular endothelial cells with decreased INSR in RCC may secrete interferon-β and induce PD-L1.
(出版サイトへのリンク): ● Publication site (DOI): 10.1038/s41416-023-02325-8
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37355721; ● Search Scopus @ Elsevier (PMID): 37355721; ● Search Scopus @ Elsevier (DOI): 10.1038/s41416-023-02325-8

(DOI: 10.1038/s41416-023-02325-8, PubMed: 37355721) 大豆本圭, 湊沙希, 小居浩之, 岸本大輝, 岩佐武, 高橋正幸, 金山博臣 :
徳島大学病院における不妊治療の取り組み,
西日本泌尿器科, Vol.85, 317-323, 2023年. Katsuhito Hori, Yutaro Sasaki, Keito Shiozaki, Fumiya Kadoriku, Kei Daizumoto, Ryotaro Tomida, Yoshiteru Ueno, Megumi Tsuda, Yoshito Kusuhara, Tomoya Fukawa, Kunihisa Yamaguchi, Yasuyo Yamamoto, Masayuki Takahashi, Yoshihiro Tsuruo and Hiroomi Kanayama :
Efficacy of fresh-frozen cadaveric surgical training for arteriovenous fistula in vascular access.,
The Journal of Vascular Access, 2023.

(要約): Twelve CST sessions were performed on nine FFCs. All training sessions allowed completion of AVF creation with a median operative time of 78.5 min. Although veins and arteries were more difficult to identify than in a living body, other surgical operations could be performed in the same way as in a living body. All the respondents stated that it was good for them to experience CST. In addition, 86% of surgeons responded that CST improved their surgical techniques, and 71% of surgeons responded that they were less anxious about AVF creation.
(出版サイトへのリンク): ● Publication site (DOI): 10.1177/11297298231169056
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37070175; ● Search Scopus @ Elsevier (PMID): 37070175; ● Search Scopus @ Elsevier (DOI): 10.1177/11297298231169056

(DOI: 10.1177/11297298231169056, PubMed: 37070175) 高橋正幸, 大豆本圭, 佐々木雄太郎, 冨田諒太郎, 上野恵輝, 津田恵, 楠原義人, 布川朋也, 山口邦久, 山本恭代, 金山博臣 :
有転移腎細胞癌に対する薬物療法のNext 10 Years,
西日本泌尿器科, Vol.85, 145-152, 2023年. Yutaro Sasaki, Masayuki Takahashi, Kyotaro Fukuta, Keito Shiozaki, Kei Daizumoto, Yoshiteru Ueno, Ryotaro Tomida, Megumi Tsuda, Yoshito Kusuhara, Tomoya Fukawa, Kunihisa Yamaguchi, Yasuyo Yamamoto, Hirofumi Izaki and Hiroomi Kanayama :
Assistent guide: A novel device for ureteral stent placement in robot-assisted intracorporeal ileal conduit.,
The International Journal of Medical Robotics + Computer Assisted Surgery : MRCAS, Vol.19, No.4, 2023.

(要約): We showed the safety and efficacy of the Assistent guide for ureteral stent placement in RICIC.
(キーワード): Humans / Cystectomy / ロボティクス (robotics) / Urinary Diversion / Stents / Ureteral Obstruction / Treatment Outcome
(出版サイトへのリンク): ● Publication site (DOI): 10.1002/rcs.2513
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36840720; ● Summary page in Scopus @ Elsevier: 2-s2.0-85149381419

(DOI: 10.1002/rcs.2513, PubMed: 36840720, Elsevier: Scopus) Megumi Tsuda, Tomoya Fukawa, Yasuyo Yamamoto, Kei Daizumoto, Yutaro Sasaki, Yoshiteru Ueno, Ryotaro Tomida, Yoshito Kusuhara, Kunihisa Yamaguchi, Masayuki Takahashi and Hiro-omi Kanayama :
Impact of early urinary catheter removal on successful voiding and physical function in stroke patients.,
The Journal of Medical Investigation : JMI, Vol.70, No.3.4, 436-442, 2023.

(要約): The aim of the present study was to identify factors related to the success of trial without catheter (TWOC) in patients with stroke and to examine the effect of the timing of urinary catheter removal on the course of stroke. Patients who were admitted to the Stroke Care Unit of our institution between March 2018 and October 2021 were included. To identify factors related to success of TWOC, a multivariate analysis was performed on the patient's condition at admission and catheter indwelling time. The patients were divided into two groups by the timing of catheter removal, and we assessed the relationship between the timing of catheter removal successful TWOC and recovery of physical function. A total of 118 patients were included. The presence of comorbidities and scores of severity and function at admission were not predictors of successful voiding. The time to achieve voiding sussess was significantly shorter in the early catheter removal group than in the later group (p<0.005). Interestingly, the early group also showed better improvements in physical function. Early removal of catheters may lead to early recovery of bladder function, improvement of physical function, and lower risk of complications in patients with stroke. J. Med. Invest. 70 : 436-442, August, 2023.
(キーワード): Humans / Urinary Catheterization / Urinary Catheters / Catheters, Indwelling / Stroke / Device Removal
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.70.436
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37940529; ● CiNii @ 国立情報学研究所 (CRID): 1390298068225662720; ● Summary page in Scopus @ Elsevier: 2-s2.0-85176414269

(DOI: 10.2152/jmi.70.436, PubMed: 37940529, CiNii: 1390298068225662720, Elsevier: Scopus) Keisuke Ozaki, Tomoya Fukawa, Kei Daizumoto, Yutaro Sasaki, Yoshiteru Ueno, Megumi Tsuda, Takayuki Uchida, Yoshito Kusuhara, Yasuyo Yamamoto, Kunihisa Yamaguchi, Masayuki Takahashi and Hiro-omi Kanayama :
The impact of nutritional status and changes of body composition on the prognosis of metastatic renal cell carcinoma patients.,
The Journal of Medical Investigation : JMI, Vol.70, No.1.2, 80-87, 2023.

(要約): Nutritional status of mRCC patients may predict changes in body composition and be associated with their prognosis. J. Med. Invest. 70 : 80-87, February, 2023.
(キーワード): Humans / Carcinoma, Renal Cell / Kidney Neoplasms / Nutritional Status / Prognosis / Body Composition / Retrospective Studies / Protein Kinase Inhibitors
(徳島大学機関リポジトリ): ● Metadata: 118311
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.70.80
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37164748; ● Search Scopus @ Elsevier (PMID): 37164748; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.70.80

(徳島大学機関リポジトリ: 118311, DOI: 10.2152/jmi.70.80, PubMed: 37164748) Yoshiteru Ueno, Tomoharu Fukumori, Yoshito Kusuhara, Tomoya Fukawa, Megumi Tsuda, Kei Daizumoto, Yutaro Sasaki, Ryotaro Tomida, Yasuyo Yamamoto, Kunihisa Yamaguchi, Chisato Tonoiso, Akiko Kubo, Takashi Kawanaka, Shunsuke Furutani, Hitoshi Ikushima, Masayuki Takahashi and Hiro-omi Kanayama :
Prostate-specific Antigen Levels Following Brachytherapy Impact Late Biochemical Recurrence in Japanese Patients With Localized Prostate Cancer.,
In Vivo, Vol.37, No.2, 738-746, 2023.

(要約): PSA levels at 5 years post-treatment were associated with long-term recurrence of localized prostate cancer, which can help alleviate patient anxiety concerning prostate cancer recurrence if PSA levels remain low at 5 years after LDR-BT.
(キーワード): Male / Humans / Prostate-Specific Antigen / Brachytherapy / Cohort Studies / East Asian People / Prostatic Neoplasms
(出版サイトへのリンク): ● Publication site (DOI): 10.21873/invivo.13136
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36881090; ● Search Scopus @ Elsevier (PMID): 36881090; ● Search Scopus @ Elsevier (DOI): 10.21873/invivo.13136

(DOI: 10.21873/invivo.13136, PubMed: 36881090) Fumiya Kadoriku, Yutaro Sasaki, Kyotaro Fukuta, Yuichiro Atagi, Keito Shiozaki, Kei Daizumoto, Ryotaro Tomida, Yoshiteru Ueno, Megumi Tsuda, Yoshito Kusuhara, Tomoya Fukawa, Yutaka Yanagihara, Kunihisa Yamaguchi, Yasuyo Yamamoto, Hirofumi Izaki, Masayuki Takahashi, Sadamu Yamashi, Masaharu Kan and Hiroomi Kanayama :
A propensity score matching study on robot-assisted radical cystectomy for older patients: comparison of intracorporeal ileal conduit and cutaneous ureterostomy.,
BMC Urology, Vol.22, No.1, 2022.

(要約): The median age was lower in the ICIC group compared with the CUS group, and the proportion of high-risk cases (ECOG-PS ≥ 2 or ASA-PS ≥ 3) did not differ. The median operation time was longer in the ICIC group, and estimated blood loss was higher, compared with the CUS group. There were no significant differences in the incidence of complications within the first 30 postoperative days, incidence of complications 30-90 days after surgery, 2-year overall survival, 2-year cancer-specific survival, and 2-year recurrence-free survival. The stent-free rate was significantly lower in the CUS group than that in the ICIC group.
(キーワード): Aged / Humans / Cystectomy / Postoperative Complications / Propensity Score / Retrospective Studies / Robotic Surgical Procedures / ロボティクス (robotics) / Treatment Outcome / Ureterostomy / Urinary Bladder Neoplasms / Urinary Diversion
(徳島大学機関リポジトリ): ● Metadata: 118559
(出版サイトへのリンク): ● Publication site (DOI): 10.1186/s12894-022-01123-3
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36344965; ● Summary page in Scopus @ Elsevier: 2-s2.0-85141380657

(徳島大学機関リポジトリ: 118559, DOI: 10.1186/s12894-022-01123-3, PubMed: 36344965, Elsevier: Scopus) Kouki Tada, Kei Daizumoto, Masayuki Takahashi, Hisanori Uehara, Megumi Tsuda, Yoshito Kusuhara, Tomoya Fukawa, Yasuyo Yamamoto, Kunihisa Yamaguchi and Hiro-omi Kanayama :
Recurrent multiple liver metastases of clear cell renal cell carcinoma with a significant response to sunitinib after nivolumab treatment.,
IJU Case Reports, Vol.6, No.1, 41-44, 2022.

(要約): The patient was a 65-year-old man who underwent open nephrectomy for RCC. After the nephrectomy, he had recurrences several times, and metastasectomy had been performed for each recurrence. At 13 years after the nephrectomy, multiple liver, and lung metastases appeared. The treatment was switched to axitinib, followed by cabozantinib, then nivolumab. The best response was PR, SD, and PD for these three drugs, and treatment duration was 14, 3, and 3 months, respectively. As the fifth line, sunitinib was administered, with significant shrinkage of the multiple liver metastases, and PR has been maintained for 34 months.
(徳島大学機関リポジトリ): ● Metadata: 118791
(出版サイトへのリンク): ● Publication site (DOI): 10.1002/iju5.12545
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36605682; ● Search Scopus @ Elsevier (PMID): 36605682; ● Search Scopus @ Elsevier (DOI): 10.1002/iju5.12545

(徳島大学機関リポジトリ: 118791, DOI: 10.1002/iju5.12545, PubMed: 36605682) K. Ozaki, Takashi Kawanaka, Tomoya Fukawa, Kei Daizumoto, Yutaro Sasaki, Megumi Tsuda, Yoshito Kusuhara, Yasuyo Yamamoto, Kunihisa Yamaguchi, Masayuki Takahashi and Hiro-omi Kanayama :
Appropriate management reduces radiation exposure in daily urological practice,
International Journal of Urology, 2022.

(要約): To identify and raise awareness of the radiation exposure of urologists due to X-ray fluoroscopic procedures in daily practice. This was a single-center, cohort study of 30 consecutive patients who underwent periodic percutaneous or transurethral replacements of urinary tract catheters. A total of 55 replacements every 3 months with cases aligned were performed by a single urologist. The urologist's radiation exposure and the incident dose to patients per case were measured with thermoluminescent dosimeters. In the latter 3-month period, the pulse fluoroscopy condition was changed from 15 to 7.5 pulses per second, and collimation was added to the field of view. In the analysis of all patients, the use of a modified pulse rate and collimation did not affect the fluoroscopy time, but it did significantly reduce the air kerma and dose area product; in addition, with respect to the medical exposure dose during percutaneous catheter replacement, fluoroscopy time was longer, but air kerma and dose area product showed significant decreases. As with decreases in medical exposure of patients, the equivalent dose for eye lenses of the urologist decreased from 1.2 mSv in the first 3-month period to 0.2 mSv in the second 3-month period. Similarly, the exposure dose for the extremities also decreased significantly, from 33.9 mSv to 8.1 mSv. Urologists are exposed to non-negligible amounts of radiation due to fluoroscopy. Appropriate management such as modified pulse fluoroscopy condition and precautions are required.
(徳島大学機関リポジトリ): ● Metadata: 118219
(出版サイトへのリンク): ● Publication site (DOI): 10.1111/iju.14971
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35851694; ● Search Scopus @ Elsevier (PMID): 35851694; ● Search Scopus @ Elsevier (DOI): 10.1111/iju.14971

(徳島大学機関リポジトリ: 118219, DOI: 10.1111/iju.14971, PubMed: 35851694) Yutaro Sasaki, Kei Daizumoto, Megumi Tsuda, Yoshito Kusuhara, Tomoya Fukawa, Kunihisa Yamaguchi, Yasuyo Yamamoto and Hiro-omi Kanayama :
Efficacy of the Mercedes-Benz closure technique for vaginal reconstruction in female robot-assisted radical cystectomy,
Asian Journal of Endoscopic Surgery, Vol.16, No.1, 23-27, 2022.

(要約): Vaginal reconstruction using the posterior vaginal wall is required following radical cystectomy in women with resection of the uterus, adnexa, and anterior vaginal wall. Roll closure and clamshell closure are two widely known techniques. Of these, clamshell closure is recommended because roll closure has a high likelihood of breakdown or a resultant canal that is too narrow for sexual intercourse. In clamshell closure, however, folding the posterior vaginal wall anteriorly can be difficult. Therefore, we devised Mercedes-Benz closure, in which the vaginal wall is sutured from three directions to form a Mercedes-Benz shape, for anastomosis without tension on the vaginal wall. The present study was performed to investigate the efficacy of this alternative surgical technique for vaginal reconstruction. Twenty-six patients who underwent vaginal reconstruction following robot-assisted radical cystectomy were divided into two groups: 15 underwent clamshell closure and 11 underwent Mercedes-Benz closure. The patients' characteristics and surgical outcomes were compared between the two groups. There were no significant differences in clinical characteristics, including age, body mass index, and prior abdominal surgery between the two groups. The median vaginal reconstruction time tended to be longer in the Mercedes-Benz closure group than in the clamshell closure group (35.0 vs. 27.0 min, p = 0.102). No complications associated with vaginal reconstruction were identified. The surgical outcomes were comparable between Mercedes-Benz closure and clamshell closure. If vaginal reconstruction with clamshell closure is difficult, Mercedes-Benz closure is a valuable alternative technique.
(キーワード): Humans / 女性 (female) / Cystectomy / ロボティクス (robotics) / Urinary Bladder Neoplasms / Vagina / Lymph Node Excision / Treatment Outcome / Robotic Surgical Procedures
(出版サイトへのリンク): ● Publication site (DOI): 10.1111/ases.13109
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35842843; ● Summary page in Scopus @ Elsevier: 2-s2.0-85145491982

(DOI: 10.1111/ases.13109, PubMed: 35842843, Elsevier: Scopus) 深谷友祐, 大豆本圭, 角陸文哉, 山本拓, 佐々木雄太郎, 尾﨑啓介, 上野恵輝, 津田恵, 楠原義人, 布川朋也, 山本恭代, 山口邦久, 高橋正幸, 金山博臣, 仁木真理子, 上原久典 :
イピリムマブ・ニボルマブ併用療法が著効した乳頭状腎細胞癌の1例,
泌尿器科紀要, Vol.68, No.4, 107-111, 2022年.

(要約): We report a case of papillary renal cell carcinoma that responded well to the combination of ipilimumab and nivolumab. The patient was a 68-year-old male who was being followed up for a small left renal mass without treatment. Two years later, computed tomography (CT) showed enlarged cervical and para-aortic lymph nodes, and lymph node biopsy suggested metastases of the cancer. After resection of the renal tumor, we performed pararenal aortic lymph node biopsy, and we diagnosed the case as papillary renal cell carcinoma type 1 with lymph node metastasis. The combination of ipilimumab and nivolumab each metastatic site showed regression on CT. Since immune-related adverse events occurred during the therapy nivolumab was discontinued, but partial response of the metastases was maintained.
(キーワード): Papillary renal cell carcinoma / Ipilimumab and nivolumab / 494.9
(出版サイトへのリンク): ● Publication site (DOI): 10.14989/actauroljap_68_4_107
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390573715168780160; ● Search Scopus @ Elsevier (DOI): 10.14989/actauroljap_68_4_107

(DOI: 10.14989/actauroljap_68_4_107, CiNii: 1390573715168780160) Yutaro Sasaki, Masayuki Takahashi, Kei Daizumoto, Megumi Tsuda, Yoshito Kusuhara, Tomoya Fukawa, Yasuyo Yamamoto, Kunihisa Yamaguchi and Hiro-omi Kanayama :
The patient-side surgeon plays a key role in facilitating robot-assisted intracorporeal ileal conduit urinary diversion in men,
Journal of Robotic Surgery, Vol.16, No.2, 437-444, 2022.

(要約): The influence of the console surgeon on the feasibility and outcome of various robot-assisted surgeries has been evaluated. These variables may be partially affected by the skills of the patient-side surgeon (PSS), but this has not been evaluated using objective data. This study aimed to describe the surgical techniques of the PSS in robot-assisted radical cystectomy (RARC) and intracorporeal ileal conduit (ICIC) urinary diversion and objectively examine the changes in surgical outcomes with increasing PSS experience. During a 3-year period, 28 men underwent RARC and ICIC urinary diversion. Clinical characteristics and surgical outcomes were compared between patients who underwent surgery early (first half group) or late in the study period (second half group). The pre-docking incision enabled easy specimen removal. The glove port technique widened the working space of the PSS. The stay suture allowed the PSS to control the distal portion of the conduit, facilitating the passage of the ureteral stents. During stoma creation, pneumoperitoneum pressure was lost by opening the abdominal cavity. To overcome this problem, the robotic arm was used to lift the abdominal wall to maintain the surgical field and facilitate the PSS procedure. Compared with the first half group, the second half group had significantly shorter times for urinary diversion (202 min vs 148 min, p < 0.001), ileal isolation and anastomosis (73 min vs 45 min, p < 0.001), and stenting (23.0 min vs 6.5 min, p < 0.001). As the experience of the PSS increased, the time of the PSS procedures decreased.
(キーワード): Cystectomy / Humans / Male / Robotic Surgical Procedures / Robotics / Surgeons / Treatment Outcome / Urinary Bladder Neoplasms / Urinary Diversion
(徳島大学機関リポジトリ): ● Metadata: 116363
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s11701-021-01256-x
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34081290; ● Search Scopus @ Elsevier (PMID): 34081290; ● Search Scopus @ Elsevier (DOI): 10.1007/s11701-021-01256-x

(徳島大学機関リポジトリ: 116363, DOI: 10.1007/s11701-021-01256-x, PubMed: 34081290) Keito Shiozaki, Yasuo Kawanishi, Yutaro Sasaki, Kei Daizumoto, Megumi Tsuda, Kazuyoshi Izumi, Yoshito Kusuhara, Tomoya Fukawa, Yasuyo Yamamoto, Kunihisa Yamaguchi, Masayuki Takahashi and Hiroomi Kanayama :
Clinical application of virtual imaging guided Robot-assisted partial nephrectomy.,
The Journal of Medical Investigation : JMI, Vol.69, No.3.4, 237-243, 2022.

(要約): Objectives : To evaluate whether virtual partial nephrectomy images could help surgeons identify vascular and collecting system around tumors during actual surgery. Materials & methods : We retrospectively analyzed 36 patients who underwent robot-assisted partial nephrectomy (RAPN) between 2016 and 2017. Virtual partial nephrectomy images were created from preoperative CT images using computer software, and then analyzed. For analysis, blood vessels and collecting system portions within a 5-mm-thick safety margin around the tumor were examined. During analysis, we predicted whether targeted vasculature around the tumor would require clipping or suturing during surgery, and also whether the collecting system would require opening during resection. Surgical outcomes for virtual partial nephrectomy analyses and actual RAPNs were compared and analyzed for sensitivity and specificity. Results : In 36 cases, 119 arteries and 100 veins were targeted on virtual partial nephrectomy images. Arterial suturing or clipping for hemostasis showed a sensitivity and specificity of 83.3% and 84.5%, respectively. For veins, the sensitivity and specificity were 39.1% and 92.2%, respectively. Collecting system opening prediction sensitivity was 85.7%, and specificity was 65.2%. Conclusion : Virtual partial nephrectomy imaging is useful for RAPN planning, particularly regarding arteries and the collecting system. It is hoped that techniques for visualizing veins will improve. J. Med. Invest. 69 : 237-243, August, 2022.
(キーワード): Humans / Kidney Neoplasms / Nephrectomy / Retrospective Studies / Robotic Surgical Procedures / Robotics / Treatment Outcome
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.69.237
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36244775; ● CiNii @ 国立情報学研究所 (CRID): 1390293788341771136; ● Search Scopus @ Elsevier (PMID): 36244775; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.69.237

(DOI: 10.2152/jmi.69.237, PubMed: 36244775, CiNii: 1390293788341771136) 佐々木雄太郎, 安宅真利花, 多田航生, 中西亮太, 橋本啓佑, 吉岡拓哉, 大豆本圭, 尾崎啓介, 上野恵輝, 津田恵, 楠原義人, 布川朋也, 山本恭代, 山口邦久, 高橋正幸, 金山博臣, 柏原秀也, 徳永卓哉 :
局所進行直腸癌に対してロボット支援骨盤内臓全摘除術および体腔内回腸導管造設術を施行した2例,
泌尿器科紀要, Vol.68, No.5, 155-159, 2021年.

(要約): We describe two cases of locally advanced rectal cancer (LARC) treated with robot-assisted total pelvic exenteration (Ra-TPE) and intracorporeal ileal conduit (ICIC). The first case was in a 71-year-old man with LARC (RbP, T4bN2bM0, cStage IIIc). He was started on bevacizumab+S-1/oxaliplatin therapy in July 2019. In April 2020, he developed Fournier's gangrene due to subcutaneous penetration of rectal cancer. Emergency drainage and colostomy were performed simultaneously, and a percutaneous vesical fistula was created. In May 2020, Ra-TPE and ICIC were performed. Histopathological analysis revealed moderately differentiated tubular adenocarcinoma (ypT3N0, RM0). At postoperative 9 months, thoracoscopic right upper lobectomy was performed for a right metastatic lung tumor. At present, ie, at postoperative 12 months, the patient has been free of recurrence and metastasis, with a carcinoembryonic antigen (CEA) level of 1.4 ng/ml and carcinoma antigen (CA) 19-9 level of 11 U/ml. The second case was in a 61-year-old man with fistula-associated anal cancer (PRb, T4N3M1b, cStage IVb). In April 2019, he was started on FOLFOXIRI+cetuximab therapy. In August 2020, Ra-TPE, ICIC, and transperineal total mesenteric excision were performed. Histopathological analysis revealed adenocarcinoma (ypT4N0, RM0). At postoperative 11 months, thoracoscopic left lower lobectomy was performed for a left metastatic lung tumor. At present, ie, at postoperative 12 months, the patient remains free of recurrence and metastasis, with a CEA level of 7.3 ng/ml and CA19-9 level of 12 U/ml. Ra-TPE, which allows transperineal removal of a specimen, can be performed as a minimally invasive surgery in combination with ICIC.
(キーワード): Robot-assisted total pelvic exenteration / Intracorporeal urinary diversion / Intracorporeal ileal conduit
(出版サイトへのリンク): ● Publication site (DOI): 10.14989/actauroljap_68_5_155
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390855656035011840; ● Search Scopus @ Elsevier (DOI): 10.14989/actauroljap_68_5_155

(DOI: 10.14989/actauroljap_68_5_155, CiNii: 1390855656035011840) 佐々木雄太郎, 角陸文哉, 深谷友祐, 山本拓, 大豆本圭, 尾崎啓介, 上野恵輝, 津田恵, 楠原義人, 布川朋也, 山本恭代, 山口邦久, 高橋正幸, 金山博臣 :
膀胱浸潤を来たした局所進行性前立腺癌に対してロボット支援腹腔鏡下膀胱前立腺全摘除術を施行した1例,
泌尿器科紀要, Vol.67, No.4, 163-166, 2021年.

(要約): While robot-assisted radical cystoprostatectomy (RARC) for locally advanced prostate cancer (LAPC) may sometimes prove to be excessive treatment, it can significantly reduce the risk of positive surgical margins and lower urinary tract obstruction in some cases. Here, we report a case of LAPC treated with RARC in a patient with right hydronephrosis due to bladder infiltration and left hypoplastic kidney. A 71-year-old man presented with frequent urination in August 2019. Prostate-specific antigen (PSA) level was 8.633 ng/ml, and magnetic resonance imaging led to the suspicion that the prostate cancer extended beyond the prostate capsule without distant metastasis. Prostatic biopsy revealed Gleason score 10 (5+5) adenocarcinoma in 8 out of 8 specimens. We diagnosed left hypoplastic kidney and LAPC with right hydronephrosis due to bladder infiltration. We performed percutaneous right nephrostomy and started neoadjuvant hormone therapy. RARC and intracorporeal ileal conduit were performed in March 2020. The prostate was adherent to the anterior surface of the rectum and was difficult to remove. At present, five months after the surgery, the patient remains free of recurrence and metastasis with PSA level <0.003 ng/ml. RARC for LAPC with bladder infiltration can be an effective therapeutic strategy in some cases.
(キーワード): Locally advanced prostate cancer / Bladder Invasion / Robot-assisted radical cystoprostatectomy
(出版サイトへのリンク): ● Publication site (DOI): 10.14989/ActaUrolJap_67_4_163
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34107613; ● Summary page in Scopus @ Elsevier: 2-s2.0-85108011497

(DOI: 10.14989/ActaUrolJap_67_4_163, PubMed: 34107613, Elsevier: Scopus) Yutaro Sasaki, Masayuki Takahashi, Keisuke Ozaki, Kei Daizumoto, Yoshiteru Ueno, Megumi Tsuda, Yoshito Kusuhara, Tomoya Fukawa, Yasuyo Yamamoto, Kunihisa Yamaguchi and Hiro-omi Kanayama :
Efficacy of the direct grasping technique using pean forceps under fluoroscopy to replace ureteral stents in women,
The Journal of Medical Investigation : JMI, Vol.3.4, No.68, 326-329, 2021.

(要約): Purpose : To evaluate the efficacy of the direct grasping technique using pean forceps under fluoroscopic guidance for ureteral stent replacement in women. Methods : Between April 2018 and September 2020, 28 female patients underwent ureteral stent replacements at our facility, and 184 stent replacement procedures were performed. A total of 127 stents were replaced using pean forceps under fluoroscopic guidance (pean forceps group), and 57 stents were replaced using the cystoscope (cystoscopy group). Clinical characteristics and surgical outcomes were compared between the groups. Results : All stents were successfully replaced. There was a statistically significant difference in the procedure time between the two groups (median [interquartile range], pean forceps group : 10.8 [8.2-13.9] minutes vs. cystoscopy group : 15.8 [11.1-20.9] minutes, P < 0.001). There were no intraoperative complications in either group and no difference in the incidence of postoperative complications (pean forceps group : 1.6% vs. cystoscopy group : 1.8%, P = 1.000). Fluoroscopy time was longer in the pean forceps group, although this difference was not statistically significant (pean forceps group : 38.9 [22.6-60.1] seconds vs. cystoscopy group : 33.0 [20.0-48.9] seconds, P = 0.0558). Conclusion : The direct grasping technique using pean forceps under fluoroscopy may be a beneficial alternative to cystoscopy for ureteral stent replacement in women. J. Med. Invest. 68 : 326-329, August, 2021.
(キーワード): 女性 (female) / Fluoroscopy / Humans / Stents / Surgical Instruments / Ureter / Ureteral Obstruction
(徳島大学機関リポジトリ): ● Metadata: 116511
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.68.326
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34759153; ● Search Scopus @ Elsevier (PMID): 34759153; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.68.326

(徳島大学機関リポジトリ: 116511, DOI: 10.2152/jmi.68.326, PubMed: 34759153) 山本恭代, 布川朋也, 津田恵, 矢野哲弘, 大豆本圭, 佐々木雄太郎, 尾﨑啓介, 上野恵輝, 楠原義人, 山口邦久, 高橋正幸, 金山博臣 :
骨盤臓器脱と膀胱憩室を同時に治療した1例,
泌尿器科紀要, Vol.66, No.8, 269-272, 2020年.

(要約): We report a case of bladder diverticulum presumably caused by lower urinary tract dysfunction due to pelvic organ prolapse (POP) simultaneously treated with transurethral coagulation (TUC) of the bladder diverticulum and laparoscopic sacrocolpopexy (LSC). A literature search showed this is the first report of bladder diverticulum and POP surgically treated at the same time. A 71-year-old woman was referred to our hospital for the treatment of cystocele. She had both storage and voiding symptoms. She had a POPQ stage III cystocele and stage I uterine prolapse. Ultrasonography and computed tomographic scan showed a large volume of residual urine along with a bladder diverticulum. Since urodynamic studies revealed a low compliance bladder and obstruction, we opined that the lower urinary tract symptoms were induced by the cystocele. TUC of the bladder diverticulum and LSC were performed at the same time. After the operation, clean intermittent catheterization (CIC) was needed once a day for one month. Gradually, residual urine decreased and CIC became unnecessary. The bladder diverticulum disappeared, and there has been no recurrence of POP.
(キーワード): Aged / Diverticulum / 女性 (female) / Humans / Lower Urinary Tract Symptoms / Pelvic Organ Prolapse / Urinary Bladder / Urinary Bladder, Overactive
(出版サイトへのリンク): ● Publication site (DOI): 10.14989/ActaUrolJap_66_8_269
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32882124; ● Summary page in Scopus @ Elsevier: 2-s2.0-85090318500

(DOI: 10.14989/ActaUrolJap_66_8_269, PubMed: 32882124, Elsevier: Scopus) 祖川麻衣子, 村尾和俊, 久保宜明, 大豆本圭, 金山博臣 :
顔面に皮疹を認めなかったBirt-Hogg-Dube症候群の1例,
臨床皮膚科, Vol.73, No.13, 1089-1094, 2019年.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390565134811658112

(CiNii: 1390565134811658112) Yoshito Kusuhara, Kei Daizumoto, Kaichi Kawai, Kento Hirayama, Minoru Kowada, Terumichi Shintani, Yayoi Fukuhara, Tsogt-Ochir Dondoo, Keisuke Ozaki, Megumi Tsuda, Tomoya Fukawa, Hiroyoshi Nakatsuji, Yoshimi Bando, Hisanori Uehara, Tomoharu Fukumori, Masayuki Takahashi and Hiro-omi Kanayama :
Low Expression of Toll-like Receptor 4 Is Associated With Poor Prognosis in Bladder Cancer.,
Anticancer Research, Vol.39, No.2, 703-711, 2019.

(要約): Low TLR4 expression was correlated with tumor progression.
(キーワード): Aged / Biomarkers, Tumor / Cell Differentiation / Cell Line, Tumor / Computational Biology / Disease Progression / Female / Gene Expression Profiling / Gene Expression Regulation, Neoplastic / Humans / Immunohistochemistry / Male / Middle Aged / Neoplasm Invasiveness / Oligonucleotide Array Sequence Analysis / Prognosis / RNA, Small Interfering / Toll-Like Receptor 4 / Urinary Bladder Neoplasms
(出版サイトへのリンク): ● Publication site (DOI): 10.21873/anticanres.13166
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30711948; ● Search Scopus @ Elsevier (PMID): 30711948; ● Search Scopus @ Elsevier (DOI): 10.21873/anticanres.13166

(DOI: 10.21873/anticanres.13166, PubMed: 30711948) 下地覚, 大豆本圭, 尾﨑啓介, 楠原義人, 布川朋也, 福森知治, 高橋正幸, 金山博臣 :
腎静脈への進展を認めた腎血管筋脂肪腫の1例,
泌尿器科紀要, Vol.64, No.5, 213-217, 2018年.

(要約): We report a case of left renal angiomyolipoma extending into the renal vein. A 67-year-old woman showed a left renal tumor which was 6 cm in diameter and had density equal to fat tissue in computed tomography. We suspected liposarcoma and performed radical nephrectomy and resection of thrombus. The pathological diagnosis was angiomyolipoma with no malignancy. To our knowledge, renal angiomyolipoma with tumor thrombus has been reported in 62 cases, and pulmonary embolism developed in 9 of these cases. We conclude that surgical treatment is effective in treating angiomyolipoma with tumor thrombus.
(キーワード): Aged / Angiomyolipoma / Female / Humans / Kidney Neoplasms / Nephrectomy / Renal Veins / Thrombosis / Tomography, X-Ray Computed
(出版サイトへのリンク): ● Publication site (DOI): 10.14989/ActaUrolJap_64_5_213
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30064160; ● Search Scopus @ Elsevier (PMID): 30064160; ● Search Scopus @ Elsevier (DOI): 10.14989/ActaUrolJap_64_5_213

(DOI: 10.14989/ActaUrolJap_64_5_213, PubMed: 30064160)

MISC

塩﨑啓登, 堀克仁, 佐々木雄太郎, 大豆本圭, 布川朋也, 中西良一, 山口邦久, 山本恭代, 山下一太, 冨田江一, 井崎博文, 高橋正幸 :
未固定新鮮凍結遺体を用いたECIRSでの職業被曝低減についての検討,
日本尿路結石症学会学術集会プログラム・抄録集, 80, 2023年.

総説・解説

研究者総覧に該当データはありませんでした。

講演・発表

Kei Daizumoto, Naoka Osafune, Kohei Torii, Ryota Nishimura, Hisanori Uehara, Mitsuki Nishiyama, Saki Kobayashi, Yutaro Sasaki, Ryotaro Tomida, Yoshito Kusuhara, Tomoya Fukawa, Kunihisa Yamaguchi and Masayuki Takahashi :
Deep learning-based depth prediction system for upper tract urothelial carcinoma,
the 111th Annual Meeting of the Japanese Urological Association (JUA), PDA-36-05, Yokohama, Apr. 2024.

(キーワード): 医用画像 (medical image) / 深層学習 (deep learning)

Kei Daizumoto, Naoka Osafune, Kohei Torii, Ryota Nishimura, Hisanori Uehara, Mitsuki Nishiyama, Saki Kobayashi, Yutaro Sasaki, Ryotaro Tomida, Yoshiteru Ueno, Yoshito Kusuhara, Tomoya Fukawa, Kunihisa Yamaguchi, Yasuyo Yamamoto, Masayuki Takahashi and Junya Furukawa :
Development of pT classification prediction system in UTUC using deep-learning,
39th Annual European Association of Urology Congress, A0130, Paris, Apr. 2024. Yasuyo Yamamoto, Megumi Tsuda, Kei Daizumoto, Yoshito Kusuhara, Tomoya Fukawa, Kunihisa Yamaguchi, Masayuki Takahashi and Hiro-omi Kanayama :
Examination of Mid-Urethral Sling (MUS) for elderly patients over 75 years old,
Athens, Oct. 2019. Masayuki Takahashi, Kei Daizumoto, Tomoya Fukawa, Yayoi Fukuhara, Ozaki Keisuke, Megumi Tsuda, Yoshito Kusuhara, Hidehisa Mori, Yasuyo Yamamoto, Kunihisa Yamaguchi, Tomoharu Fukumori and Hiro-omi Kanayama :
The significance of insulin receptor expression to predict the resistance to VEGFR-TKIs and induce PD-L1 expression in advanced clear cell renal cell carcinoma,
2019 ASCO Genitourinary Cancers Symposium, Feb. 2019. Yasuyo Yamamoto, Yoshito Kusuhara, Tomoya Fukawa, Kunihisa Yamaguchi, Tomoharu Fukumori, Masayuki Takahashi, Hiro-omi Kanayama, Yoshihiro Tsuruo, Kei Daizumoto and Hidehisa Mori :
Usefulness of Fresh Frozen Cadaver and Animal Models for Surgical Training in Laparoscopic Sacrocolpopexy,
The 36th World Congress of Endourology, Paris, Sep. 2018. Masayuki Takahashi, Kei Daizumoto, Yayoi Fukuhara, Ozaki Keisuke, Megumi Tsuda, Yoshito Kusuhara, Hidehisa Mori, Tomoya Fukawa, Yasuyo Yamamoto, Kunihisa Yamaguchi, Tomoharu Fukumori and Hiro-omi Kanayama :
Correlation of the insulin receptor expression changes by the administration of VEGFR-TKI and the resistance to the VEGFR-TKI in clear cell renal cell carcinoma,
113th American Urological Association Annual meeting, May 2018. 山本恭代, 佐々木雄太郎, 津田恵, 大豆本圭, 楠原義人, 古川順也, 山口邦久, 高橋正幸 :
女性膀胱癌患者におけるRARC後のPOP発症を予防する腟再建の工夫,
日本排尿機能学会誌, 山本恭代, 布川朋也, 津田恵, 佐々木雄太郎, 高橋正幸, 金山博臣, 大豆本圭, 楠原義人, 山口邦久 :
RASCにおけるPSS(Patient Side Surgeon)の役割,
日本女性骨盤底医学会, Hiroshi Miyamoto, Ayuka Mineda, Sawaka Yukishige, Soichiroh Sasa, Kei Daizumoto, Tomoya Fukawa, Yasuyuki Okada, Yasuhiro Mitsui, Koichi Okamoto, Yasushi Sato, Hiroyuki Morino and Tetsuji Takayama :
Management of patients with presumed germline pathogenic variant from comprehensive genomic profiling tests.,
日本人類遺伝学会第69回大会, Oct. 2024. 塩﨑啓登, 堀克仁, 佐々木雄太郎, 大豆本圭, 山下一太, 布川朋也, 中西良一, 山本恭代, 山口邦久, 井崎博文, 高橋正幸, 冨田江一 :
未固定新鮮凍結遺体を用いたECIRSでの職業被曝低減についての検討,
第33回日本尿路結石学会, 2024年8月. 松本力三, 大豆本圭, 西尾進, 湯浅麻美, 平田有紀奈, 古川順也, 佐田政隆 :
ロボット手術後の腎エコー,
第97回日本超音波医学会学術集会, 2024年5月. 平岡淳一郎, 新井悠太, 岩本誠司, 岡田直子, 松下知樹, 廣島由夏, 新家崇義, 原田雅史, 大豆本圭, 楠原義人, 曽我部公子, 藤井志朗 :
後天性von Willebrand病により術後止血に難渋した1例,
第268回徳島医学会学術集会, 2024年3月. 平岡淳一郎, 新井悠太, 岩本誠司, 岡田直子, 松下知樹, 廣島由夏, 新家崇義, 原田雅史, 大豆本圭, 楠原義人, 曽我部公子, 藤井志朗 :
von Willebrand病により術後止血に難渋した1例,
2023年12月. 塩﨑啓登, 堀克仁, 佐々木雄太郎, 大豆本圭, 布川朋也, 中西良一, 山本恭代, 山口邦久, 井崎博文, 高橋正幸, 金山博臣, 冨田江一 :
Cadaver surgical trainingにおける内シャント造設の試み,
第53回徳島透析療法研究会, 2023年12月. 松本力三, 西尾進, 大豆本圭, 森田沙瑛, 湯浅麻美, 平田有紀奈, 山尾雅美, 齋藤裕, 楠瀬賢也, 山田博胤, 島田光生, 佐田政隆 :
後腹膜リンパ節転移を生じたBurned-out testicular tumorの1例,
第48回日本超音波検査学会学術集会, 2023年6月. 山本恭代, 津田恵, 大豆本圭, 佐々木雄太郎, 楠原義人, 布川朋也, 山口邦久, 高橋正幸, 金山博臣 :
80歳以上の間質性膀胱炎患者に対するDMSO膀胱内注入療法,
日本老年泌尿器科学会誌, 2023年5月. 山本恭代, 布川朋也, 津田恵, 大豆本圭, 佐々木雄太郎, 楠原義人, 山口邦久, 高橋正幸, 金山博臣 :
当院におけるロボット支援下仙骨腟固定術の現況,
骨盤臓器脱手術手技研究会, 2023年3月. 石原玲央, 大豆本圭, 堀克仁, 角陸文哉, 佐々木雄太郎, 冨田諒太郎, 上野恵輝, 津田恵, 楠原義人, 布川朋也, 山本恭代, 山口邦久, 高橋正幸, 金山博臣, 西村良太 :
Deep-learningを用いた尿管癌についての検討,
第266会徳島医学会学術集会(令和4年度冬期), No.A-25, 266, 2023年2月.

(要約): 【目的】近年，画像診断技術が進化しているが，尿管癌描出や深達度についての診断精度は低い．特に尿管癌深達度診断技術は，薬物療法前に重要であり早期の開発が求められている．そこで今回我々はDeep Learning(深層学習)によるAI(人工知能)による画像学習を利用してCT画像から尿管癌の深達度を予測するシステムの構築を行うためのパイロットスタディを行ったので報告する．【方法】2009年から2020年に徳島大学病院で尿管癌に対して腎尿管全摘除術を施行された157例のうち下部尿管癌30例のCT画像をAI に学習させ画像分類を行い，学習の適合率を評価した．摘出標本のマクロ画像での癌の位置とCTの位置を照らし合わせて，癌領域を決定し，各CTスライスを「癌を含む」と「癌を含まない」に分類した．【結果】AIによるCT画像の下部尿管癌の判定正解率は，学習回数が100回の時点での学習済みデータを用いてテストした場合は 99.94%，未学習のデータでテストした場合は99.15%となった．今回の学習では過学習は認められなかった．【結論】AIによるCT画像の下部尿管癌の評価を行った．今回の設定でCT画像から癌の有無の判定の学習が可能であると考えられた．今後はAIによってCT画像から尿管癌の場所の特定や深達度予測の評価を行い，実臨床で応用可能な評価モデルの確立を目指す．

高橋正幸, 大豆本圭, 福田喬太郎, 安宅祐一朗, 泉和良, 楠原義人, 布川朋也, 金山博臣 :
進行性腎細胞癌に対するニボルマブ・イピリムマブ併用療法の検討: 多施設共同後ろ向き研究,
日本泌尿器腫瘍学会第8回, 2022年10月. 土岐俊一, 西庄俊彦, 上原久典, 坂東良美, 尾矢剛志, 髙尾正一郎, 外礒千智, 新井悠太, 西村正人, 高橋正幸, 大豆本圭, 渡辺浩良, 宮城亮, 滝沢宏光, 吉川幸造, 徳永卓哉, 安倍吉郎, 中村信元, 宮本弘志, 西良浩一 :
肉腫診療における多施設多診療科多職種カンファレンスの意義,
第35回日本臨床整形外科学会学術集会【開催期間:2022年7月17日-18日】, 2022年7月. 山本恭代, 津田恵, 大豆本圭, 佐々木雄太郎, 上野恵輝, 楠原義人, 布川朋也, 山口邦久, 高橋正幸, 金山博臣 :
女性神経因性膀胱患者に対するボツリヌス毒素膀胱壁内注入療法の経験,
日本女性骨盤底医学会, 2022年7月.

(キーワード): 女性 (female) / 神経因性膀胱 / ボツリヌス毒素膀胱壁内注入療法

堀克仁, 佐々木雄太郎, 角陸文哉, 塩崎啓登, 大豆本圭, 冨田諒太郎, 上野恵輝, 津田恵, 楠原義人, 布川朋也, 山口邦久, 山本恭代, 高橋正幸, 金山博臣 :
当院での未固定遺体を用いた内シャント造設術トレーニングの試み ∼生体との違いについて∼,
日本泌尿器科学会四国地方会, 2022年7月. 佐々木雄太郎, 堀克仁, 角陸文哉, 大豆本圭, 上野恵輝, 冨田諒太郎, 津田恵, 楠原義人, 布川朋也, 山口邦久, 山本恭代, 高橋正幸, 金山博臣 :
多診療科で行うロボット支援手術 ∼後方骨盤内臓全摘除術の1例∼,
日本泌尿器科学会四国地方会, 2022年7月. 山本恭代, 津田恵, 安宅真利花, 大豆本圭, 楠原義人, 布川朋也, 山口邦久, 高橋正幸, 金山博臣 :
当院における難治性過活動膀胱に対するボツリヌス毒素膀胱壁内注入療法の臨床的検討,
日本老年泌尿器科学会誌, Vol.35, No.1, 144, 2022年6月.

(キーワード): 難治性過活動膀胱 / ボツリヌス毒素膀胱壁内注入療法

西尾進, 大豆本圭, 平田有紀奈, 松本力三, 湯浅麻美, 森田沙瑛, 山口夏美, 山尾雅美, 高橋正幸, 佐田政隆 :
造影超音波検査による術前シミュレーションが有用であったパラガングリオーマの 1 例,
日本超音波医学会第95回学術集会, 2022年5月. 橋本啓佑, 佐々木雄太郎, 安宅真利花, 多田航生, 中西亮太, 吉岡拓哉, 大豆本圭, 尾崎啓介, 上野恵輝, 津田恵, 楠原義人, 布川朋也, 山本恭代, 山口邦久, 高橋正幸, 金山博臣 :
ロボット支援体腔内回腸導管造設術においてストマ造設を円滑に行うための工夫,
日本ロボット外科学会学術集会, 2022年2月. 佐々木雄太郎, 福田喬太郎, 大豆本圭, 塩崎啓登, 楠原義人, 布川朋也, 中西良一, 山本恭代, 山口邦久, 井崎博文, 高橋正幸, 神田和哉, 金山博臣 :
高齢患者(≧75歳)のロボット支援膀胱全摘除術における体腔内回腸導管造設術と尿管皮膚瘻造設術の比較,
日本泌尿器科学会総会, 2021年12月. 山本恭代, 津田恵, 大豆本圭, 佐々木雄太郎, 楠原義人, 布川朋也, 山口邦久, 高橋正幸, 金山博臣 :
当院における外来排尿自立指導の臨床的検討,
日本泌尿器科學會雜誌, 2021年12月. 佐々木雄太郎, 大豆本圭, 塩崎啓登, 布川朋也, 山本恭代, 山口邦久, 井崎博文, 高橋正幸, 神田和哉, 金山博臣 :
「アシステントガイド」の開発体腔内回腸導管造設時の尿管ステント留置を円滑に,
日本泌尿器内視鏡学会総会, 2021年11月. 山本恭代, 津田恵, 大豆本圭, 佐々木雄太郎, 楠原義人, 布川朋也, 山口邦久, 高橋正幸, 金山博臣 :
憩室口が遠位に存在する尿道憩室摘除術における工夫,
西日本泌尿器科, Vol.83, 2021年11月. 山本恭代, 大豆本圭, 佐々木雄太郎, 津田恵, 楠原義人, 布川朋也, 山口邦久, 高橋正幸, 金山博臣 :
夜間頻尿に対するデスモプレシンの使用経験,
日本排尿機能学会誌, Vol.32, No.1, 2021年9月. 山本恭代, 津田恵, 大豆本圭, 佐々木雄太郎, 楠原義人, 布川朋也, 山口邦久, 高橋正幸, 金山博臣 :
骨盤臓器脱に対し膣閉鎖術を行った症例の検討,
日本女性骨盤底医学会, 2021年7月. 山本恭代, 津田恵, 大豆本圭, 楠原義人, 布川朋也, 山口邦久, 高橋正幸, 金山博臣 :
難治性過活動膀胱に対するボツリヌス毒素膀胱壁内注入療法の初期治療経験,
日本老年泌尿器科学会誌, Vol.34, No.1, 109, 2021年5月. 高橋正幸, 楠原義人, 佐々木雄太郎, 大豆本圭, 尾﨑啓介, 上野恵輝, 津田恵, 布川朋也, 山本恭代, 山口邦久, 金山博臣 :
ロボット支援下腎盂形成術-温故創新成人水腎症に対するロボット支援腎盂形成術の初期経験,
第33回日本内視鏡外科学会総会, 2021年3月. 高橋正幸, 矢野哲弘, 大豆本圭, 佐々木雄太郎, 尾﨑啓介, 上野恵輝, 津田恵, 楠原義人, 森英恭, 布川朋也, 山本恭代, 山口邦久, 金山博臣 :
転移性腎細胞癌に対するニボルマブ・イピリムマブ併用療法の初期経験,
第108回日本泌尿器科学会総会, 2020年12月. 山本恭代, 布川朋也, 津田恵, 大豆本圭, 楠原義人, 山口邦久, 高橋正幸, 金山博臣 :
腹腔鏡下仙骨腟固定術前後で比較した下部尿路機能症状とQOLの変化,
第108回日本泌尿器科学会総会, 2020年12月. 山本恭代, 布川朋也, 津田恵, 大豆本圭, 楠原義人, 山口邦久, 高橋正幸, 金山博臣 :
骨盤臓器脱患者に対する腹腔鏡下仙骨腟固定術前後での下部尿路症状の変化,
第82回西日本泌尿器科学会総会, 2020年11月. 山本恭代, 津田恵, 大豆本圭, 楠原義人, 布川朋也, 山口邦久, 高橋正幸, 金山博臣 :
TOT手術時のヘガールを用いたテープ調整の有用性,
第27回日本排尿機能学会, 2020年10月. 松本力三, 西尾進, 大豆本圭, 森田沙瑛, 湯浅麻美, 平田有紀奈, 山尾雅美, 田中貴大, 金山博臣, 佐田政隆 :
多房性嚢胞状腎細胞癌の2症例,
日本超音波医学会第30回四国地方会学術集会, 2020年10月. 宇都義浩, 大豆本圭, 福原弥生, 上原久典, 金山博臣 :
発育鶏卵を用いた患者由来がんモデルの開発,
第24回日本がん分子標的治療学会学術集会, 2020年10月. 高橋正幸, 大豆本圭, 布川朋也, 金山博臣 :
転移性腎細胞癌に対するニボルマブ・イピリムマブ併用療法の初期経験,
第24回日本がん分子標的治療学会学術集会, 2020年10月. 大豆本圭, 福原弥生, 布川朋也, 片桐豊雅, 上原久典, 高橋正幸, 金山博臣 :
尿路上皮癌に対するDDX31/NCL相互作用阻害による抗腫瘍効果の検討,
第79回日本癌学会学術総会, 2020年10月. 津田恵, 山本恭代, 大豆本圭, 楠原義人, 布川朋也, 山口邦久, 高橋正幸, 金山博臣 :
泌尿器科疾患以外の患者に対する排尿ケアチーム介入の臨床的検討,
第33回日本老年泌尿器科学会総会, 2020年9月. 宇都義浩, 小西大輔, 折村奈美, 山田久嗣, 富永正英, 生島仁史, 大豆本圭, 上原久典 :
リニアックの FFFビームに対する新規増感剤の創製,
第22回癌治療増感シンポジウム, 2020年2月. 小西大輔, 二若真菜, 藤原由莉, 折村奈美, 山田久嗣, 富永正英, 生島仁史, 上原久典, 大豆本圭, 宇都義浩 :
医療用直線加速器の高線量率モードX線に対するGemcitabineの増感効果,
日本化学会中国四国支部大会徳島大会, 2019年11月. 高橋正幸, 大豆本圭, 佐々木雄太郎, 尾﨑啓介, 上野恵輝, 津田恵, 楠原義人, 森英恭, 布川朋也, 山本恭代, 山口邦久, 金山博臣 :
転移性腎細胞癌に対しニボルマブ・イピリムマブ併用療法を施行した4例の症例報告,
2019年10月. 加藤廉平, 布川朋也, 松下洋輔, 吉丸哲郎, 尾野雅哉, 大豆本圭, 加藤陽一郎, 小原航, 片桐豊雅 :
腎癌の癌化におけるPRELID2によるミトコンドリアROS制御機構の解明,
第78回日本癌学会学術総会, 2019年9月. 山本恭代, 布川朋也, 大豆本圭, 津田恵, 楠原義人, 森英恭, 山口邦久, 高橋正幸, 金山博臣 :
RARPにおける術前残尿量と術後尿禁制の関連,
第26回日本排尿機能学会, 2019年9月. 山本恭代, 布川朋也, 津田恵, 大豆本圭, 楠原義人, 森英恭, 山口邦久, 福森知治, 高橋正幸, 金山博臣 :
骨盤臓器脱と膀胱憩室を同時に治療した1例,
第21回女性骨盤底医学会, 2019年7月. 高橋正幸, 大豆本圭, 尾﨑啓介, 津田恵, 楠原義人, 森英恭, 布川朋也, 山本恭代, 山口邦久, 福森知治, 金山博臣 :
高齢腎癌患者に対する根治的腎摘除術/腎部分切除術の臨床的検討,
第50回腎癌研究会記念大会, 2019年7月. 山本恭代, 大豆本圭, 楠原義人, 津田恵, 森英恭, 布川朋也, 山口邦久, 福森知治, 高橋正幸, 金山博臣 :
排尿ケアチームが複数回介入した症例の検討,
日本泌尿器科學會雜誌, 2019年4月. 高橋正幸, 西山美月, 福田喬太郎, 大豆本圭, 尾﨑啓介, 津田恵, 楠原義人, 森英恭, 布川朋也, 山本恭代, 山口邦久, 福森知治, 金山博臣 :
小児膀胱尿管逆流症に対する気膀胱下Cohen法の初期治療経験,
第107回日本泌尿器科学会総会, 2019年4月. 山本恭代, 山口邦久, 福森知治, 高橋正幸, 金山博臣, 大豆本圭, 楠原義人, 森英恭 :
排尿ケアチーム設立時の現況と課題,
第70回西日本泌尿器科学会総会, 2018年11月. Masayuki Takahashi, Kei Daizumoto, Ozaki Keisuke, Tsuda Megumi, Yoshito Kusuhara, Hidehisa Mori, Tomoya Fukawa, Yasuyo Yamamoto, Kunihisa Yamaguchi, Tomoharu Fukumori and Hiro-omi Kanayama :
Clinicopathological study of the elderly patients with renal cell carcinoma who underwent radical/partial nephrectomy,
第56回日本癌治療学会学術集会, Oct. 2018. Masayuki Takahashi, Kei Daizumoto, Yayoi Fukuhara, Minoru Kowada, Yoshimi Bando, Tomoya Fukawa, Tomoharu Fukumori and Hiro-omi Kanayama :
The significance of insulin receptor expression in vascular endothelial cells of clear cell renal cell carcinoma,
第77回日本癌学会学術集会, Sep. 2018. 山本恭代, 大豆本圭, 楠原義人, 森英恭, 布川朋也, 山口邦久, 福森知治, 高橋正幸, 金山博臣, 鶴尾吉宏 :
腹腔鏡下仙骨膣固定術導入にむけたトレーニング,
第20回日本女性骨盤底医学会, 2018年7月. 高橋正幸, 大豆本圭, 尾﨑啓介, 津田恵, 楠原義人, 森英恭, 布川朋也, 山本恭代, 山口邦久, 福森知治, 金山博臣 :
ニボルマブ投与中にhyper-progressionが疑われた淡明細胞型腎細胞癌の1例,
第49回腎癌研究会, 2018年7月. 高橋正幸, 尾﨑啓介, 楠原義人, 福田喬太郎, 西山美月, 大豆本圭, 津田恵, 森英恭, 布川朋也, 山本恭代, 山口邦久, 福森知治, 金山博臣 :
高齢の腎癌患者に対する手術,
第31回日本老年泌尿器科学会, 2018年5月. 山本恭代, 大豆本圭, 楠原義人, 森英恭, 布川朋也, 山口邦久, 福森知治, 高橋正幸, 金山博臣 :
TOT術後の過活動膀胱(OAB)治療に関する検討,
第106回日本泌尿器科学会総会, 2018年4月. Masayuki Takahashi, Kei Daizumoto, Yayoi Fukuhara, Ozaki Keisuke, Megumi Tsuda, Yoshito Kusuhara, Hidehisa Mori, Tomoya Fukawa, Yasuyo Yamamoto, Kunihisa Yamaguchi, Tomoharu Fukumori and Hiro-omi Kanayama :
Correlation of the insulin receptor expression changes by the administration of VEGFR-TKI and the resistance to the VEGFR-TKI in clear cell renal cell carcinoma,
第106回日本泌尿器科学会総会, Apr. 2018.

研究会・報告書: 研究者総覧に該当データはありませんでした。

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補助金・競争的資金: Mutant p53 - DDX31 axisから紐解くCancer Immunology Research (研究課題/領域番号: 23K08758 )
患者由来癌組織を用いたRCC Precision Medicine Project (研究課題/領域番号: 23K08736 )
がん由来エクソソームによる筋細胞内代謝制御の解明とがん悪液質の克服 (研究課題/領域番号: 23K06613 )
LEDを用いた次世代「光」不妊治療の開発 (研究課題/領域番号: 21K19573 )
「DDX31」遺伝子改変による尿路上皮癌自然発癌モデルによる免疫複合治療の開発 (研究課題/領域番号: 21K16755 )
鶏卵を用いた次世代患者由来がんモデルの作製と薬剤スクリーニング法の確立 (研究課題/領域番号: 19K22689 )
尿路上皮癌の多段階進展機構の先進的病態解明と革新的治療開発 (研究課題/領域番号: 19K18612 )
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受賞: 2024年4月, 第111回日本泌尿器科学会総会Best Poster Award (日本泌尿器科学会)
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Jグローバル最終確認日: 2024/12/21 01:23
氏名（漢字）: 大豆本圭
氏名（フリガナ）: ダイズモトケイ
氏名（英字）: KEI DAIZUMOTO
所属機関: 徳島大学大学院医歯薬学研究部助教

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researchmap最終確認日

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氏名（漢字）

大豆本圭

氏名（フリガナ）

ダイズモトケイ

氏名（英字）

KEI DAIZUMOTO

プロフィール

三重県鈴鹿市出身で私立・鈴鹿中学高等学校卒業後、2004年徳島大学医学部医学科へ入学した。2010年3月徳島大学医学部医学科を卒業後、2010年10月徳島大学大学院医科学教育部・泌尿器科学分野へ入学し泌尿器がんを中心に癌研究を行ってきた。2018年4月医学博士を取得後、実臨床での疑問点にフォーカスし患者様へ還元できる研究を志している。2019年よりメンズヘルス外来にて勃起不全症、男性不妊症を担当し臨床と研究面から疾患にアプローチしている。

代表的な研究テーマ

「尿路上皮癌における多段階進展機構の解明　DDX31-Mutant p53 -EGFR axis　」

「患者腫瘍組織移植モデル(PDX :Patient-Derived Xenograft)の作製研究」免疫不全マウス、鶏卵モデル

「ディープラーニングを用いた上部尿路上皮癌のAI開発」

「男性不妊症に関する精子活性化研究」

「術後勃起不全に対するヘルスケア機器「TENGA」を用いたリハビリテーションの有効性に関する前向き研究」

　https://jrct.niph.go.jp/latest-detail/jRCTs062220057　TENGAヘルスケア社との特定臨床研究

学歴/職歴

2004年　徳島大学医学部医学科入学

2010年　徳島大学医学部医学科卒業

2010年　徳島大学大学院入学

2013年4月～　徳島大学病院泌尿器科医員

2013年5月～2015年6月　徳島大学先端酵素学研究所　ゲノム制御学分野　片桐豊雅研究室

泌尿器がん基礎研究に従事

2017年　泌尿器科専門医取得

2018年　医学博士授与

2019年4月　徳島大学病院泌尿器科・特任助教　

2020年4月　徳島大学大学院　医歯薬学研究部　泌尿器科学分野　助教

2021年5月　泌尿器腹腔鏡技術認定医

2023年9月　性機能学会専門医

資格　泌尿器科学会専門医・指導医

　　　泌尿器腹腔鏡技術認定医

性機能学会専門医

da Vinci Surgical System certificate

　　　hinotori™ certificate

登録日時

2018/9/10 15:26

更新日時

2024/12/20 15:46

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ＫＡＫＥＮで最新データを確認する

2024年12月21日更新

研究者番号: 10745516

所属（現在）: 2024/4/1 : 徳島大学, 大学院医歯薬学研究部(医学域), 助教

所属（過去の研究課題 情報に基づく）*注記: 2020/4/1 – 2023/4/1 : 徳島大学, 大学院医歯薬学研究部(医学域), 助教
2020/4/1 : 徳島大学, 大学院医歯薬学研究部, 助教
2019/4/1 : 徳島大学, 病院, 特任助教

審査区分/研究分野

研究代表者

小区分56030:泌尿器科学関連

研究代表者以外

中区分56:生体機能および感覚に関する外科学およびその関連分野
小区分50010:腫瘍生物学関連
小区分56030:泌尿器科学関連

キーワード

研究代表者

尿路上皮癌 / DDX31 / TP53 / p53 / 多段階進展 / EGFR / BBN / 膀胱癌 / 多段階発癌 / mutant p53

研究代表者以外

腎細胞癌 / 尿路上皮癌 / PDX / 鶏卵 / 個別化医療 / CAM / 泌尿器癌 / 薬剤耐性 / 薬剤スクリーニング / LED / 男性不妊症 / 精子無力症 / 精子 / sperm analysis / TESE / ICSI / AIH / 悪液質 / エクソソーム / 腎癌

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