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菅俊行

徳島大学

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2024年12月20日更新

職名: 講師
電話: 088-633-7340
電子メール: suge@dent.tokushima-u.ac.jp
学歴: 1991/3: 徳島大学歯学部歯学科卒業
学位: 博士(歯学) (大阪大学) (1999年2月)
職歴・経歴: 1991/7: 徳島大学歯学部附属病院医員(歯科·研修医)
1992/4: 徳島大学歯学部助手
2004/4: 徳島大学大学院ヘルスバイオサイエンス研究部歯科保存学分野助手

専門分野・研究分野: 歯科保存学 (Conservative Dentistry)

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2024年12月20日更新

専門分野・研究分野: 歯科保存学 (Conservative Dentistry)
担当経験のある授業科目: (臨床系)国家試験・CBT対策講義 (学部)
保存修復学各論 (学部)
保存修復学実習 (学部)
保存修復学総論 (学部)
再生歯科治療学 (大学院)
口腔感染症学 (大学院)
口腔機能再建学実験実習 (大学院)
歯内治療学 (学部)
歯内治療学1 (学部)
歯科保存学(1) 実習 (学部)
歯科保存学(1)B 講義 (学部)
総合歯科学三 (学部)
臨床実習 (学部)
臨床実習(5年) (学部)
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2024年12月20日更新

専門分野・研究分野: 歯科保存学 (Conservative Dentistry)

研究テーマ: 象牙質知覚過敏症に関する研究, アパタイト析出法を利用した象牙質知覚過敏症の治療法の開発に関する研究 (アパタイト, リン酸カルシウム, 象牙質知覚過敏症)

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論文

高原由実子, 三木浩和, 中村信元, 林成樹, 住谷龍平, 大浦雅博, 曽我部公子, 髙橋真美子, 丸橋朋子, 富永誠記, 岡本秀樹, 岡田直人, 矢野由美子, 高橋真理, 大坂朱美, 原田武志, 藤井志朗, 菅俊行, 青田桂子, 尾崎修治, 安倍正博 :
徳島県におけるHIV感染症および後天性免疫不全症候群患者の臨床的特徴と今後の課題,
四国医学雑誌, Vol.78, No.5-6, 193-198, 2022年.

(要約): 【Introduction】The survival rate in patients with HIV infection and acquired immunodeficiency syndrome (AIDS) has been improved dramatically due to the advances in anti-HIV drug therapy, while aging-associated complications become a critical issue. The incidence of sudden occurrence of AIDS without prior detection of HIV infection, so called ``Ikinari AIDS'', still remains high. 【Objective】We retrospectively analyzed the incidence and clinical characteristics of HIV/AIDS patients in both Tokushima University Hospital and Tokushima Prefectural Central Hospital. 【Results】Eighty four patients (74 males and 10 females) with a median age of 39 years old (range 16 - 85) were enrolled. Thirty-four patients (40.5%) were diagnosed with ``Ikinari AIDS'' from 2001 to 2020. All 4 patients were diagnosed with ``Ikinari AIDS'' after 2020. AIDS-defining illnesses were diagnosed as follows ; pneumocystis pneumonia in 21 cases, CMV infection in 8 cases and candidiasis in 6 cases. All patients over 60 years old were suffered from AIDS. Other complications included syphilis in 17 cases, hepatitis B infection in 12 and herpes zoster in 7. 【Discussion/Conclusion】In Tokushima, the incidence rate of ``Ikinari AIDS'' appeared to be higher than that of national average. COVID - 19 pandemic hampered the public health care services of awareness-raising activity for HIV infection and telephone consultations about HIV, which may become more lease asymptomatic HIV patients without diagnosis. For early diagnosis of HIV/AIDS, it is becoming more important to share information to make early screening of HIV infection among medical staffs, such as medical doctors, dentists, nurses, pharmacists and MSWs.
(キーワード): HIV / AIDS / Ikinari AIDS
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1520013962706680448

(CiNii: 1520013962706680448) 西條早希, 中村信元, 三木浩和, 谷口早紀, 岡本秀樹, 富永誠記, 岡田直人, 矢野由美子, 髙橋真理, 青田桂子, 菅俊行, 渡邊浩良, 大坂朱美, 安倍正博 :
徳島大学病院における先天性血友病患者(成人例)の実態調査∼移行期医療の重要性∼,
四国医学雑誌, Vol.77, No.5-6, 261-268, 2021年.

(要約): 【Introduction】Congenital hemophilia is a category of hemorrhagic disease caused by a genetic defect in the production of coagulation factors. It is treated by administering regular coagulation factor injections on an ongoing basis. Hemophilia is a hereditary illness, often causing social and psychological problems as a result of the disease. To analyze the objective effects of hemophilia, we conducted a retrospective analysis in Tokushima University Hospital. 【Result】All 23 cases were men between the ages of20and72. Hemophilia A was present in17cases, and hemophilia B was present in six. Nineteen out of 23 cases were severe, and the others were intermediate. Medical assessments were conducted at pediatrics in seven cases and hematology in 16 cases. Adoption of the self-injection technique was not realized in five cases. Seventeen cases were complicated by hemophilic arthropathy, seven with human immunodeficiency virus(HIV), and 12 with hepatitis C virus. Eight participants were unemployed, and17were unmarried. 【Discussion】 Many adult hemophilia patients still visit pediatrics in our hospital. Hemophilia in the period of growth between adolescence and young adulthood is often accompanied by life-altering events such as entering higher education, marriage, and work experience. Therefore, collaboration among professionals of multiple occupations, such as doctors, nurses, pharmacists, medical social workers, and clinical psychologists, is essential. Furthermore, there are many cases of HIV and hepatitis C virus infections complicating hemophilia study due to the stigma surrounding HIV-tainted blood. 【Conclusion】It is imperative that we establish a long-term, sustainable, and multi-disciplinary transitional care and medical support system for patients and their families.
(キーワード): Congenital Hemophilia / Transitional Care
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1520855132284626560

(CiNii: 1520855132284626560) Toshiyuki Suge, Ishikawa Kunio and Takashi Matsuo :
Changes in the crystallinity of hydroxyapatite powder and structure of enamel treated with several concentrations of ammonium hexafluorosilicate,
American Journal of Dentistry, Vol.25, No.5, 299-302, 2012.

(要約): To evaluate the effects of changing concentrations of ammonium hexafluorosilicate [SiF: (NH4)2SiF6] solution on the crystallinity of hydroxyapatite powder (HAP) and structure of human enamel in order to overcome the tooth discoloration caused by diamine silver fluoride [AgF: (NH3)2AgF] application. HAP was treated with several concentrations of SiF solution (from 10 to 19,400 ppm) for 5 minutes. The crystallinity of the HAP before and after SiF treatment was then measured by powder X-ray diffraction (XRD) analysis. The angular width (beta) of the 002 diffraction peak was measured at 1/2 the height of the maximum intensity. Also, enamel specimens were prepared from a human extracted tooth. Several concentrations of SiF solution were applied to polished or phosphoric acid etched enamel specimens. The enamel surface was then observed using scanning electron microscopy (SEM). XRD peaks became sharper after SiF treatment indicating that the crystallinity of apatite powder was increased. The 1/beta value was increased from 2.8 +/- 0.1 to 4.3 +/- 0.1 after treatment with 1,000 ppm SiF solution. The amount of CaF2 formed in HAP was gradually increased with increasing concentrations of SiF solution. TheXRD pattern was consistent with CaF2 in case of over 9,000 ppm SiF solution. SEM photographs demonstrated that exposed enamel rods with acid etching were filled with CaF2-like precipitate after SiF treatment regardless of the concentration of SiF solution.
(キーワード): Adult / Crystallization / Dental Enamel / Durapatite / Fluorides / Humans / Powders / Quaternary Ammonium Compounds / Silicic Acid
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23243979; ● Search Scopus @ Elsevier (PMID): 23243979

(PubMed: 23243979) Shibata Shingo, Toshiyuki Suge, Tomoko Kimura, Ishikawa Kunio and Takashi Matsuo :
Antibacterial activity of ammonium hexafluorosilicate solution with antimicrobial agents for the prevention of dentin caries,
American Journal of Dentistry, Vol.25, No.1, 31-34, 2012.

(要約): This study evaluated the antibacterial activity of the SiF solution with the addition of antibacterial agents on a Streptococcus mutans biofilm. Various antibacterial SiF solutions were prepared by adding chlorhexidine, cetylpyridinium chloride, isopropyl methylphenol, or epigallocatechin gallate. Hydroxyapatite pellets treated with several SiF solutions were immersed in BHI inoculated with S. mutans standardized suspension. The number of S. mutans cells adhered to each pellet was evaluated. SiF with the addition of CPC was the most effective for reducing the adherence of bacteria and inhibiting the formation ofbiofilm, showing the same level as AgF, In contrast, the addition of other antibacterial agents to SiF reduced the original antibacterial activity of SiF solution.
(キーワード): Ammonium hexafluorosilicate / Fluoride / Dentin caries
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22558689; ● Search Scopus @ Elsevier (PMID): 22558689

(PubMed: 22558689) Shinya Horiuchi, Shingo Kuroda, Masahiro Hiasa, Toshiyuki Suge, Seitaro Saku, Kenichi Hamada, Takashi Matsuo, Kenzo Asaoka and Eiji Tanaka :
Reinforcement of bond strength of self-etching orthodontic adhesive.,
The Angle Orthodontist, Vol.82, No.1, 30-35, 2011.

(要約): Abstract Objective: To determine the reinforcement of bond strength of a self-etching system by applying a pretreatment agent. Materials and Methods: Sixty extracted human premolars were used in this study. The enamel surfaces were treated with four pretreatment agents?phosphoric acid, polyacrylic acid, citric acid, and ammonium hexafluorosilicate (SiF)?and were examined under a scanning electron microscope. Afterward, orthodontic brackets were bonded with a self-etching adhesive system (n ?=? 10 for each agent), and shear bond strength was measured through a debonding process. The adhesive remnant index (ARI) was also assessed. Results: Enamel surfaces treated with polyacrylic acid seemed almost the same as intact enamel. Treatment with SiF induced slight shallow depressions compared with the intact enamel. On the other hand, enamel surfaces treated with citric acid and phosphoric acid showed severe etching patterns. All pretreatments increased the bond strength, but SiF-treated specimens revealed the greatest strength (12.201 ? 1.048?MPa), followed by polyacrylic acid (12.030 ? 2.103?MPa). The control group with no pretreatment showed the least strength (9.078 ? 1.678?MPa). All pretreatments increased ARI score compared with the control group. Conclusions: Surface conditioning before bracket adhesion could reinforce the bond strength of the self-etching adhesive system, resulting in a more reliable bonding system.
(出版サイトへのリンク): ● Publication site (DOI): 10.2319/012011-39.1
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21751834; ● Search Scopus @ Elsevier (PMID): 21751834; ● Search Scopus @ Elsevier (DOI): 10.2319/012011-39.1

(DOI: 10.2319/012011-39.1, PubMed: 21751834) Toshiyuki Suge, Akiko Kawasaki, Ishikawa Kunio, Takashi Matsuo and Ebisu Shigeyuki :
Effects of ammonium hexafluorosilicate concentration on dentin tubule occlusion and composition of the precipitate,
Dental Materials, Vol.26, No.1, 29-34, 2010.

(要約): Ammonium hexafluorosilicate [SiF: (NH(4))(2)SiF(6)] was prepared in order to overcome the tooth discoloration caused by diamine silver fluoride [AgF: (NH(3))(2)AgF] application. We employed a single concentration of SiF solution in our previous study; therefore, it is still unclear how the concentration of SiF solution affects the occlusion of dentin tubules and composition of the precipitate. The aim of this study was to evaluate the effects of changing the concentration of SiF on its clinical use as a dentin hypersensitivity treatment. To simulate dentin tubules subject to dentin hypersensitivity, dentin disks were treated with EDTA for 2 min. Then, the disks were treated with several concentrations of SiF solution (from 100 to 19,400 ppm) for 3 min. The occlusion of dentin tubules was evaluated using scanning electron microscopy (SEM), and the composition of the precipitate formed in the tubules after SiF treatment was assessed using energy dispersive X-ray analysis (EDXA). SEM photographs demonstrated that dentin tubules after treatment with SiF were occluded homogeneously and fully regardless of the concentration of SiF solution. The Ca/P molar ratio of the precipitate formed in dentin tubules after SiF treatment was increased with the concentration of SiF solution. It was concluded that the capacity to occlude dentin tubules was the same regardless of the concentration of SiF solution. However, the composition of the precipitate formed in the tubules was dependent on the concentration of SiF solution.
(キーワード): Calcium / Chemical Precipitation / Dentin / Dentin Desensitizing Agents / Dentin Permeability / Dentin Sensitivity / Electron Probe Microanalysis / Fluorides / Humans / Hydrogen-Ion Concentration / Materials Testing / Microscopy, Electron, Scanning / Phosphorus / Quaternary Ammonium Compounds / Silicic Acid / Silicon Compounds / Time Factors / Tooth Discoloration
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.dental.2009.08.011
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19748664; ● Search Scopus @ Elsevier (PMID): 19748664; ● Search Scopus @ Elsevier (DOI): 10.1016/j.dental.2009.08.011

(DOI: 10.1016/j.dental.2009.08.011, PubMed: 19748664) 菅俊行, 石川邦夫, 松尾敬志, 恵比須繁之 :
フッ化ジアミンシリケートの象牙質知覚過敏症治療剤への応用―抜去歯を用いた象牙細管封鎖能の検討―,
日本歯科保存学雑誌, Vol.50, No.3, 313-320, 2007年.

(要約): フッ化ジアンミン銀(サホライド^[○!R])は,齲蝕進行抑制剤および象牙質知覚過敏症治療剤として臨床で使用されている.しかしながら,フッ化ジアンミン銀は塗布後に銀の沈着による歯の黒変が起こる.したがって,フッ化ジアンミン銀は主に乳歯に使用されている.この欠点を改良するために,フッ化ジアミンシリケートを調製した.銀の代わりにシリカを導入した理由は,シリカは歯質の変色を起こさないこと,そして擬似体液からアパタイトの生成を誘導するからである.本研究の目的はヒト口腔内を模倣した環境下において,フッ化ジアミンシリケート処理後の象牙細管封鎖効果と持続性を評価することである.フッ化ジアミンシリケートの象牙細管封鎖効果は,ヒト抜去歯を用いて評価を行った.フッ化ジアミンシリケート処理直後および人工唾液浸漬7日後の象牙質プレートの表面を,走査電子顕微鏡(SEM)にて観察を行った.SEM観察の結果,開口象牙細管はフッ化ジアミンシリケート処理直後にはシリカ-リン酸カルシウム結晶により完全に封鎖されていた.さらに,人工唾液浸漬7日後には象牙質表面は新たに生成した結晶により覆われていた.EDXA分析によると,フッ化ジアミンシリケート処理直後に象牙細管内に析出した結晶はシリカ,カルシウム,リンを含有しており,シリカ-リン酸カルシウム結晶であることが明らかとなった.その結晶のカルシウムとリンのモル比はフッ化ジアミンシリケート処理直後には2.02であったが,人工唾液浸漬後には徐々に減少した.一方,象牙質表面に新たに生成した結晶は実験期間を通して,ほぼ一定の値(Ca/P=1.16∼1.28)であった.周囲の管間象牙質と比べて有意に低い値であることから,おそらくカルシウム欠損アパタイトが析出していると推察された.フッ化ジアミンシリケート処理は人工唾液中からリン酸カルシウムの析出を誘導し,したがって,ヒト口腔内を模倣した環境下において,持続的な象牙細管封鎖能を有することが明らかとなった.
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390001205520321280

(CiNii: 1390001205520321280) Toshiyuki Suge, Akiko Kawasaki, Kunio Ishikawa, Takashi Matsuo and Shigeyuki Ebisu :
Ammonium hexafluorosilicate elicits calcium phosphate precipitation and shows continuous dentin tubule occlusion,
Dental Materials, Vol.24, No.2, 192-198, 2007.

(要約): Diamine silver fluoride [AgF: (NH(3))(2)AgF] has been used clinically in Japan, as it reduces dental caries and dentin hypersensitivity. However, AgF stains the teeth black due to silver precipitation. To overcome this drawback, the authors prepared ammonium hexafluorosilicate [SiF: (NH(4))(2)SiF(6)], which does not stain the teeth, and SiF occluded open dentin tubules completely with silica-calcium phosphate precipitate. The aim of this study was to evaluate the duration of dentin tubule occlusion after SiF treatment in a simulated oral environment. To simulate dentin tubules subject to dentin hypersensitivity, dentin disks were treated with EDTA for 2 min. The disks were treated with 0.476 mol/L SiF for 3 min, and then the disks were immersed in synthetic saliva, which was regularly replenished to maintain its ionic concentration, for up to 7 days. The occluding ability of the dentin tubules was evaluated using scanning electron microscopy (SEM), and the hydraulic conductance was measured following Pashley's method at regular intervals. SEM photographs demonstrated that dentin tubules were occluded homogeneously and completely with the precipitate at 7 days after treatment with SiF. In addition, newly formed calcium phosphate precipitate was present at the dentin surface. The dentin permeability showed a consistently low value throughout the experimental period. The values immediately after SiF treatment and 7 days after immersion were 11.9+/-3.7% and 7.9+/-2.9%, respectively. Ammonium hexafluorosilicate is useful for the treatment of dentin hypersensitivity, since ammonium hexafluorosilicate induced calcium phosphate precipitation from the saliva; therefore, it has a continuous effect on dentin tubules occlusion under a simulated oral environment.
(キーワード): Adult / Calcium Phosphates / Chelating Agents / Chemical Precipitation / Dentin / Dentin Permeability / Dentin Sensitivity / Edetic Acid / Electron Probe Microanalysis / Fluorides / Humans / Materials Testing / Microscopy, Electron, Scanning / Saliva, Artificial / Silicic Acid / Smear Layer / Time Factors
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.dental.2007.03.009
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 17544103; ● Summary page in Scopus @ Elsevier: 2-s2.0-37349046709

(DOI: 10.1016/j.dental.2007.03.009, PubMed: 17544103, Elsevier: Scopus) Toshiyuki Suge, Akiko Kawasaki, Kunio Ishikawa, Takashi Matsuo and Shigeyuki Ebisu :
Effect of ammonium hexafluorosilicate on dentin tubule occlusion for the treatment of dentin hypersensitivity,
American Journal of Dentistry, Vol.19, No.4, 248-252, 2006.

(要約): To evaluate the occluding ability of ammonium hexafluorosilicate (SiF). Dentin disks prepared from human extracted teeth were grouped as follows to prepare different situations of dentin hypersensitivity: (1) those sonicated for 20 minutes; (2) those treated with 0.5 mol/L EDTA for 2 minutes; (3) those treated with 6% citric acid for 2 minutes; (4) those treated with 50% citric acid for 2 minutes. Then, SiF or diamine silver fluoride (AgF) was applied to the dentin disks and the dentin tubule occlusion was observed with scanning electron microscopy (SEM). The percent of open tubules before and after SiF or AgF treatment were measured by NIH image using SEM photographs. Also, the dentin permeability was measured. SEM micrographs demonstrated that the dentin tubules were completely occluded by the precipitate after SiF treatment. Also, the dentin permeability was reduced to 10.3%. In contrast, most of the dentin tubules remained open after AgF treatment. EDXA analysis showed that the precipitate in the dentin tubules that forms after SiF treatment contains Si, Ca and P, indicating a silica-calcium phosphate complex.
(キーワード): Acids / Adult / Analysis of Variance / Citric Acid / Dentin / Dentin Permeability / Dentin Sensitivity / Edetic Acid / Fluorides / Humans / Silicic Acid
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 16939033; ● Search Scopus @ Elsevier (PMID): 16939033

(PubMed: 16939033) Toshiyuki Suge, Akiko Kawasaki, Kunio Ishikawa, Takashi Matsuo and Shigeyuki Ebisu :
Effects of plaque control on the patency of dentinal tubules-an in vivo study in beagle dogs,
Journal of Periodontology, Vol.77, No.3, 454-459, 2006.

(要約): The aim of this in vivo study was to evaluate the effects of plaque control on the patency of dentinal tubules using vital teeth of beagle dogs. Class V cavities were prepared on the cervical areas of the mandibular and maxillary molars in each dog with a diamond point. To simulate the state of dentinal hypersensitivity, the teeth were etched with 50% citric acid for 2 minutes to obtain patent dentinal tubules. Plaque control was achieved by brushing the left-side teeth every day, whereas no plaque control was performed for the right-side teeth. A dentin biopsy was performed after 1, 2, and 3 weeks using the cylindrical diamond point to obtain dentin specimens. In the plaque control group, some of the dentinal tubules were occluded with precipitate (Ca/P=1.49), and the diameter of the dentinal tubules decreased from 2.42+/-0.33 microm (mean+/-SD) to 1.11+/-0.51 microm after 7 days, although most of the dentinal tubules remained open. In contrast, no precipitate was observed in the dentinal tubules of the non-plaque control group. Also, the diameter of the dentinal tubules increased from 2.42+/-0.33 to 2.9+/-0.49 microm, due to the demineralization of the peritubular and intertubular dentin. Plaque control plays a key role in reducing the patency of dentinal tubules and, therefore, might promote the natural repair of dentinal hypersensitivity.
(キーワード): Analysis of Variance / Animals / Calcium Phosphates / Dental Plaque / Dentin / Dentin Permeability / Dentin Sensitivity / Dogs / Electron Probe Microanalysis / Microscopy, Electron, Scanning / Toothbrushing
(出版サイトへのリンク): ● Publication site (DOI): 10.1902/jop.2006.050159
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 16512760; ● Summary page in Scopus @ Elsevier: 2-s2.0-33646346136

(DOI: 10.1902/jop.2006.050159, PubMed: 16512760, Elsevier: Scopus) Toshiyuki Suge, Akiko Kawasaki, Kunio Ishikawa, Takashi Matsuo and SHigeyuki Ebisu :
Comparison of the occluding ability of dentinal tubules with different morphology between calcium phosphate precipitation method and potassium oxalate treatment,
Dental Materials Journal, Vol.24, No.4, 522-529, 2005.

(要約): The aim of this study was to evaluate the occluding ability of calcium phosphate precipitation (CPP) method and potassium oxalate treatment when each method was applied to dentin disks with different surface morphology. Occluding ability was observed by scanning electron microscopy. Irrespective of the diameter of the dentinal tubules, the CPP method showed a consistent occluding ability for dentinal tubules at the dentin surface, and that the depths of the precipitate formed in the dentinal tubules by CPP method were not significantly different. In contrast, the occluding ability of potassium oxalate treatment was reduced with increasing diameter of the dentinal tubules. However, the reduction of the occluding ability of potassium oxalate treatment was more markedly affected by the demineralization of dentin surface. Since the CPP method showed a consistent occluding ability irrespective of the diameter of the dentinal tubules, it is suggested that the CPP method would be a useful means for treating dentin hypersensitivity.
(キーワード): Adult / Calcium Phosphates / Dentin / Dentin Permeability / Dentin Sensitivity / Humans / Microscopy, Electron, Scanning / Oxalates / Surface Properties
(出版サイトへのリンク): ● Publication site (DOI): 10.4012/dmj.24.522
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 16445013; ● Search Scopus @ Elsevier (PMID): 16445013; ● Search Scopus @ Elsevier (DOI): 10.4012/dmj.24.522

(DOI: 10.4012/dmj.24.522, PubMed: 16445013) Akiko Kawasaki, Toshiyuki Suge, Kunio Ishikawa, Kazumi Ozaki, Takashi Matsuo and Shigeyuki Ebisu :
Ammonium hexafluorosilicate increase acid resistance of bovine enamel and dentine,
Journal of Materials Science. Materials in Medicine, Vol.16, No.5, 461-466, 2005.

(要約): Although diamine silver fluoride (AgF: (NH3)2AgF) stains teeth black, it is known as a very effective agent to prevent the dental caries progress. In order to find another fluoride that has a similar anticariogenic effect without changing tooth color, we prepared ammonium hexafluorosilicate (SiF: (NH4)2SiF6), in which the silver of AgF is replaced with silicon. In this study, the anticariogenic effect of SiF was evaluated using bovine teeth. Fluoride solutions, SiF, AgF, acidulated phosphate fluoride (APF), and sodium fluoride (NaF), were applied to bovine enamel and dentine blocks, and the depth of demineralization was measured after exposure to a demineralizing solution for 24 h. Also, fluoride was applied to a simulated dentine caries specimen to evaluate the caries progress-preventing ability. For the dentine specimens, mineral loss (Delta Z) was also measured with microradiography. We found that SiF treated enamel showed better acid resistance than specimens treated with NaF or APF. AgF treated enamel also showed similar acid resistance, but was stained black. SiF and AgF treated caries-affected dentine showed reduced demineralization when exposed to a demineralization solution for 24 h. Mineral loss (Delta Z) was reduced to 85% and 75%, respectively. Although the acid resistance of the SiF treated teeth was inferior to that of the AgF treated teeth, we consider that SiF has good potential as anticariogenic agent, since it increased acid resistance without changing tooth color.
(キーワード): Acids / Animals / Biocompatible Materials / Calcification, Physiologic / Cattle / Dental Caries / Dental Enamel / Dentin / Drug Resistance / Fluorides / Hydrogen-Ion Concentration / Incisor / Silicic Acid
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s10856-005-6987-2
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15875257; ● Search Scopus @ Elsevier (PMID): 15875257; ● Search Scopus @ Elsevier (DOI): 10.1007/s10856-005-6987-2

(DOI: 10.1007/s10856-005-6987-2, PubMed: 15875257) Toshiyuki Suge, Ishikawa Kunio, Akiko Kawasaki, Takashi Matsuo and EBISU Shigeyuki :
Effects of pre- or post- application with calcium chloride on occluding ability of potassium oxalate for the treatment of dentin hypersensitivity,
American Journal of Dentistry, Vol.18, No.2, 121-125, 2005.

(要約): To evaluate whether calcium ion supply using 1-6 mol/L CaCl2 solution could enhance the occluding ability of dentin tubules with 30% potassium oxalate treatment. Calcium chloride solution (1-6 mol/L) was applied to dentin disks before or after application of 30% potassium oxalate solution. Occluding ability after potassium oxalate treatment was evaluated with scanning electron microscopic (SEM) observation and measurement of dentin permeability. In addition, the composition of the precipitate formed when mixing potassium oxalate and calcium chloride was analyzed with a powder x-ray diffractometer (XRD). SEM observations revealed that the dentin tubules were occluded homogeneously and completely with the precipitate when calcium chloride solution was applied before or after potassium oxalate treatment. However, the depth of the precipitate in dentin tubules from the dentin surface became shallower when pre-treated with calcium chloride before potassium oxalate. Although dentin permeability was greatly reduced in both groups, no significant difference could be observed between samples with and without calcium chloride application.
(キーワード): Adult / Calcium Chloride / Chemical Precipitation / Dentin / Dentin Permeability / Dentin Sensitivity / Drug Synergism / Humans / Microscopy, Electron, Scanning / Oxalates / X-Ray Diffraction
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15973832; ● Search Scopus @ Elsevier (PMID): 15973832

(PubMed: 15973832) Toshiyuki Suge, Kunio ISHIKAWA, Akiko Kawasaki, Kazuomi SUZUKI, Takashi Matsuo, Yuichiro NOIRI, Satoshi IMAZATO and Shigeyuki EBISU :
Calcium phosphate precipitation method for the treatment of dentin hypersensitivity,
American Journal of Dentistry, Vol.15, No.4, 220-226, 2002.

(要約): To evaluate the feasibility of the calcium phosphate precipitation (CPP) method as a treatment for dentin hypersensitivity using vital teeth of beagle dogs. Also, gingival tissue response to two types of CPP methods was examined histologically. Dentin tubules of the dogs' vital teeth were exposed by shallow cavity preparation followed by etching with 50% citric acid to simulate the condition of hypersensitive dentin. After CPP treatment was applied to the vital tooth, the dentin surface and longitudinal sections were observed by SEM to evaluate the occluding ability of the CPP method. The precipitate was also analyzed by energy-dispersive X-ray microanalysis to obtain compositional information. The gingival tissue before and after CPP method was examined histologically with light microscopy. Dentin tubules were occluded homogeneously and completely with an apatitic mineral after application of the CPP treatment in vital teeth. However, the depth of the precipitate in dentin tubules from the dentin surface was approximately half that seen in extracted teeth. No histological change was observed in gingival tissues when NaHCO3 was used as a post-treatment solution of the CPP method, whereas another CPP method using NaOH solution resulted in atrophy and degeneration of the epithelium of gingival tissue.
(キーワード): Analysis of Variance / Animals / Calcium Phosphates / Chemical Precipitation / Dentin / Dentin Permeability / Dentin Sensitivity / Dogs / Electron Probe Microanalysis / Feasibility Studies / Gingiva / Microscopy, Electron, Scanning
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12572638; ● Summary page in Scopus @ Elsevier: 2-s2.0-0037844949

(PubMed: 12572638, Elsevier: Scopus) Akiko Kawasaki, Kunio ISHIKAWA, Toshiyuki Suge, Hirotoshi SHIMIZU, Kazuomi SUZUKI, Takashi Matsuo and Shigeyuki EBISU :
Effects of plaque control on the patency and occlusion of dentine tubules in situ.,
Journal of Oral Rehabilitation, Vol.28, No.5, 439-449, 2001.

(要約): To elucidate the nature of dentine hypersensitivity, the effects of plaque control on the patency and occlusion of dentinal tubules were investigated systematically in situ using human dentine slabs embedded in partial dentures. The dentine slabs were divided into three groups. In group I, the dentine slabs were kept in an oral cavity without plaque control. In group II, plaque was removed mechanically by brushing. Plaque control was carried out chemically using chlorhexidine in group III. After being kept in the oral cavities for 1, 2 and 3 weeks, the slabs were removed from the partial denture, followed by SEM observation to determine the morphological changes of the dentinal tubules. When no attempt was made to remove plaque, the diameter of tubule orifices increased to 390% of the original values within 3 weeks. In contrast, dentinal tubules were found to be occluded, i.e. the tubule orifices became <20% of the original value within 1 week when plaque control efforts were made, using either method of plaque control. We conclude that plaque control plays one of the key roles in the patency versus occlusion of dentinal tubules, and thus in the aetiology and natural reparative process of dentine hypersensitivity.
(キーワード): Adult / Anti-Infective Agents, Local / Calcium / Chlorhexidine / Dental Plaque / Dentin / Dentin Sensitivity / Dentin, Secondary / Electron Probe Microanalysis / Follow-Up Studies / Humans / Hydrogen-Ion Concentration / Magnesium / Male / Microscopy, Electron / Microscopy, Electron, Scanning / Phosphates / Phosphorus / Saliva / Spectrophotometry, Ultraviolet / Statistics as Topic / Toothbrushing
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11380784; ● Search Scopus @ Elsevier (PMID): 11380784

(PubMed: 11380784) Toshiyuki Suge, Kunio ISHIKAWA, Akiko Kawasaki, Kazuomi SUZUKI, Takashi Matsuo and Shigeyuki EBISU :
Evaluation of post-treatment solutions for clinical use with the calsium phosphate precipitation method,
Journal of Dentistry, Vol.27, No.7, 487-496, 1999.

(要約): We have proposed a calcium phosphate precipitation (CPP) method that occludes dentine tubules with apatitic minerals for the treatment of dentine hypersensitivity. The current CPP method uses 1 mol/l NaOH as the post-treatment solution. However, its high pH is not desirable for clinical use. The aim of this study was to evaluate several solutions, especially buffer solutions, as post-treatment solutions for the CPP method. The CPP solution was mixed with several post-treatment solutions at various mixing ratios in test tubes. The precipitates were collected, and freeze-dried in a vacuum. Their weights were measured to evaluate the feasibility of buffer solution for the post-treatment solutions. Among the solutions, we selected one buffer solution and have done further evaluation using human dentine disks. The degree of occlusion of dentine tubules was evaluated by scanning electron microscopic observation and measurement of dentine permeability. Also, the composition of the precipitate was analyzed using energy-dispersive X-ray microanalysis and powder X-ray diffraction. Among the solutions, 1 mol/l NaHCO3 gave sufficient amounts of precipitate at a relatively mild pH, and thus was considered to be a good candidate for a post-treatment solution. Scanning electron microscopic observation showed that dentine tubules were occluded with the precipitate to a depth of approximately 10 microns from the surface when the CPP treatment was done twice, and dentine permeability was reduced to 98.8%. The precipitate was dicalcium phosphate dihydrate (DCPD; CaHPO4-2H2O) when the post-treatment solution was free of NaF. In contrast, the precipitate was an apatitic mineral with CaF2 as a by-product when the post-treatment solution contained NaF. We concluded that 1 mol/l NaHCO3 containing 0.3 mol/l NaF would be suitable as the post-treatment solution for the CPP method as it has a relatively mild pH and occludes dentinal tubules well.
(キーワード): Adult / Apatites / Buffers / Calcium Phosphates / Chemical Precipitation / Dentin / Dentin Permeability / Dentin Sensitivity / Electron Probe Microanalysis / Evaluation Studies as Topic / Feasibility Studies / Freeze Drying / Humans / Hydrogen-Ion Concentration / Microscopy, Electron, Scanning / Sodium Bicarbonate / Sodium Fluoride / Sodium Hydroxide / X線回折 (X-ray diffraction)
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0300-5712(99)00033-0
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10507204; ● Summary page in Scopus @ Elsevier: 2-s2.0-0033191462

(DOI: 10.1016/S0300-5712(99)00033-0, PubMed: 10507204, Elsevier: Scopus) Masahiro YOSHIYAMA, Toshiyuki Suge, Akiko Kawasaki and Shigeyuki EBISU :
Morphological characterization of tube-like structures in hypersensitive human radicular dentine,
Journal of Dentistry, Vol.24, No.1-2, 57-63, 1996.

(要約): The objective of this work was to determine if there were differences in the distribution of tube-like structures within the tubules of biopsies from hypersensitive versus non-sensitive human cervical radicular dentine. Ten pairs of dentine were made from the exposed sensitive and non-sensitive radicular dentine of nine adult patients complaining of dentine sensitivity. The biopsies were made with a small hollow diamond bur. The specimens were submitted to HCl-collagenase treatment to partially digest the surface to permit visualization of subsurface structures. Half of the specimens were embedded in resin to facilitate longitudinal sectioning, and the other half were processed with embedding for SEM and EDS observation. Biopsies from hypersensitive regions exhibited hollow, tube-like structures within the lumina of dentinal tubules in 75.8 +/- 9.4%) ( mean +/- S.D.) of the tubules. In biopsies of non-sensitive areas of the same teeth, these tube-like structures were only seen in 20.4 +/- 8.5% of the tubules. In specimens that were embedded prior to treatment with HCl-collagenase, resin tags penetrated many of the tubules from hypersensitive dentine but few of the tubules from non-sensitive dentine. It is speculated that tube-like structures found in hypersensitive dentine play a role in maintaining the patency of the tubules which may prevent physicochemical processes from spontaneously occluding the tubules, thereby maintaining dentine sensitivity.
(キーワード): Adult / Biopsy / カルシウム (calcium) / Chemical Phenomena / 物理化学 (physical chemistry) / Collagenases / Dentin / Dentin Sensitivity / Electron Probe Microanalysis / Histocytological Preparation Techniques / Humans / Hydrochloric Acid / Microscopy, Electron, Scanning / Microtomy / Middle Aged / リン (phosphorus) / Resins, Synthetic / Silicon Dioxide / Sulfur / Tissue Embedding / チタン (titanium) / Tooth Root
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/0300-5712(95)00016-X
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 8636493; ● Summary page in Scopus @ Elsevier: 2-s2.0-0029689640

(DOI: 10.1016/0300-5712(95)00016-X, PubMed: 8636493, Elsevier: Scopus) Akiko Kawasaki, Kunio Ishikawa, Toshiyuki Suge, Masahiro Yoshiyama, Kenzo Asaoka and Shigeyuki Ebisu :
Effects of hexafluorosilicate on the precipitate composition and dentine tubule occlusion by calcium phosphate,
Journal of Dentistry, Vol.24, No.6, 429-434, 1996.

(要約): To improve the calcium phosphate precipitation (CPP) method for the occlusion of dentine tubules with calcium phosphate, the addition of calcium hexafluorosilicate (CaSiF6) to CPP solution was evaluated in vitro with respect to its occluding capacity and the composition of the precipitate. The occlusion of dentine tubules was evaluated by SEM observations and by measurements of dentine permeability. The composition of the precipitate was determined by measuring the calcium to phosphorus (Ca/P) ratio of the precipitate in dentine tubules by energy dispersive X-ray spectroscopy (EDS). The addition of CaSiF6 to the CPP solution resulted in an increase of the Ca/P ratio in the precipitate not only on the dentine surface but also inside the dentine tubules; indicating that the precipitate became more apatitic in nature. The addition of CaSiF6 had no effect on occluding capacity in terms of measurements of dentine permeability or SEM observations. Dentine permeability decreased to approximately 4% of pretreatment values and the dentine tubules were occluded for approximately 10-15 microns from the dentine surface. It is concluded that the addition of CaSiF6 to CPP solution was desirable, since it provided a more apatitic precipitate in the dentine tubules, not only on the dentine surface but also inside the tubules, and there were no drawbacks with respect to its occluding capacity.
(キーワード): Apatites / カルシウム (calcium) / Calcium Phosphates / Chemical Precipitation / Dentin / Dentin Permeability / Durapatite / Electron Probe Microanalysis / Fluorides / Humans / Microscopy, Electron, Scanning / リン (phosphorus) / Silicates / Silicic Acid
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/0300-5712(95)00101-8
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 8990689; ● Summary page in Scopus @ Elsevier: 2-s2.0-0030276650

(DOI: 10.1016/0300-5712(95)00101-8, PubMed: 8990689, Elsevier: Scopus) Toshiyuki Suge, Kunio Ishikawa, Akiko Kawasaki, Masahiro Yoshiyama, Kenzo Asaoka and Shigeyuki Ebisu :
Effects of fluoride on the calcium phosphate pricipitation method for dentinal tubules occlusion,
Journal of Dental Research, Vol.74, No.4, 1079-1085, 1995. Toshiyuki Suge, Kunio Ishikawa, Akiko Kawasaki, Masahiro Yoshiyama, Kenzo Asaoka and Shigeyuki Ebisu :
Duration of dentinal tubule occlusion formed by calcium phosphate precipitation method: in vitro evaluation using synthetic saliva,
Journal of Dental Research, Vol.74, No.10, 1079-1714, 1995. Kunio Ishikawa, Toshiyuki Suge, Masahiro Yshiyama, Akiko Kawasaki, Kenzo Asaoka and Shigeyuki Ebisu :
Occlusion of dentinal tubules with calcium phosphate using acidic calcium phosphate solution followed by neutralization.,
Journal of Dental Research, Vol.73, No.6, 1197-1204, 1994. 吉山昌宏, 菅俊行, 川﨑有希子, 恵比須繁之 :
プライマー処理による歯頚部磨耗象牙質の微細形態学的変化,
日本歯科保存学雑誌, Vol.37, No.2, 404-410, 1994年. 吉山昌宏, 菅俊行, 川﨑有希子, 大木元玲子, 恵比須繁之 :
象牙質知覚過敏症の発症機構, --- レジンライナー塗布法による有効例および無効例の微細形態学的検討 ---,
日本歯科保存学雑誌, Vol.36, No.1, 200-205, 1993年.

MISC

菅俊行 :
象牙質知覚過敏症の病態と治療法,
四国歯学会雑誌, Vol.26, No.2, 55-60, 2014年.

(キーワード): 象牙質知覚過敏症 / 象牙細管 / 動水力学説
(徳島大学機関リポジトリ): ● Metadata: 109845

(徳島大学機関リポジトリ: 109845) Toshiyuki Suge and Takashi Matsuo :
Effects of ammonium hexafluorosilicate concentration on crystallinity of hydroxyapatite powder and enamel,
Key Engineering Materials, Vol.529-530, 526-530, 2013.

(出版サイトへのリンク): ● Publication site (DOI): 10.4028/www.scientific.net/KEM.529-530.526
(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-84871313515

(DOI: 10.4028/www.scientific.net/KEM.529-530.526, Elsevier: Scopus) Toshiyuki Suge, Akiko Kawasaki, Kunio Ishikawa, Takashi Matsuo and Shigeyuki Ebisu :
A new treatment method for dentin hypersensitivity: application of ammonium hexafluorosilicate solution,
Dental tribune, Asia Pacific edition, Vol.4, No.12, 10-12, 2006. Masahiro YOSHIYAMA, Toshiyuki Suge, Akiko Kawasaki and Shigeyuki EBISU :
Process-like structures in the tubules of hypersensitive human dentine.,
Archives of Oral Biology, Vol.39, No.Suppl, 153, 1994.

総説・解説

武川大輔, 米倉和秀, 蔵本瞳, 伊田百美香, 細川由樹, 細川育子, 細川義隆, 菅俊行, 中西正, 保坂啓一 :
2級コンポジットレジン修復のキーポイント,
Journal of Oral Health and Biosciences, Vol.36, No.1, 8-12, 2023年9月.

(キーワード): 歯科医療 (dental care)
(徳島大学機関リポジトリ): ● Metadata: 118637
(出版サイトへのリンク): ● Publication site (DOI): 10.20738/johb.36.1_8
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390016062665364224; ● Search Scopus @ Elsevier (DOI): 10.20738/johb.36.1_8

(徳島大学機関リポジトリ: 118637, DOI: 10.20738/johb.36.1_8, CiNii: 1390016062665364224)

講演・発表

Akiko Kawasaki, Toshiyuki Suge, Kunio ISHIKAWA and Takashi Matsuo :
Effect of ammonium hexafluorosilicate on acid resistance of enamel and dentin,
Sydney, May 2004. Toshiyuki Suge, Akiko Kawasaki, Kunio Ishikawa and Takashi Matsuo :
Occlusion of dentinal tubules with ammonium hexafluorosilicate for treatment of dentin hypersensitivity,
7th World Biomaterials Congress, Sydney, May 2004. Akiko Kawasaki, Toshiyuki Suge, Kunio Ishikawa, Kazumi Ozaki, Takashi Matsuo and Shigeyuki Ebisu :
Ammonium hexafluorosilicate increase acid resistance of bovine enamel and dentin,
Journal of Dental Research, Vol.82, No.Special Issue B, B-71, Goteborg, Jun. 2003. Toshiyuki Suge, Kunio Ishikawa, Akiko Kawasaki, Takashi Matsuo and Shigeyuki Ebisu :
Duraiton of ammonium hexafluorosilicate for dentinal tubules occlusion,
Journal of Dental Research, Vol.82, No.Special Issue B, B-47, Goteborg, Jun. 2003. Akiko Kawasaki, Toshiyuki Suge, Kunio ISHIKAWA, Kazumi Ozaki and Takashi Matsuo :
Ammonium hexafluorosilicate increased acid resistance of bovine enamel and dentin,
Transactions of the fourth international congress on dental materials, Vol.16, 195, Honolulu, Jan. 2002. Toshiyuki Suge, Kunio ISHIKAWA, Akiko Kawasaki, Takashi Matsuo and Shigeyuki EBISU :
Effects of ammonium hexafluorosilicate on dental tubules' occlusion,
Transactions of the fourth international congress on dental materials, Vol.16, 253, Honolulu, Jan. 2002. Akiko Kawasaki, Toshiyuki Suge, Kunio ISHIKAWA, Kazuomi SUZUKI, Takashi Matsuo and Shigeyuki EBISU :
Effects of ammonium hexafluorosilicate on occluion of dentinal tubules,
Journal of Dental Research, Vol.80, No.Special Issue, 750, Makuhari, Jun. 2001. Toshiyuki Suge, Kunio ISHIKAWA, Akiko Kawasaki, Kazuomi SUZUKI, Takashi Matsuo and Shigeyuki EBISU :
CaCl2 increase dentinal tubules occlusion ablity of potassium oxalate treatment,
Journal of Dental Research, Vol.80, No.Special Issue, 750, Makuhari, Jun. 2001. Akiko Kawasaki, ISHIKAWA Kunio, Toshiyuki Suge, SUZUKI Kazuomi, Takashi Matsuo and EBISU Shigeyuki :
In vivo evaluation of plaque control on dentin hypersensitivity,
Journal of Dental Research, Vol.77, No.Special Issue, 571, Nice, Jun. 1998. Toshiyuki Suge, ISHIKAWA Kunio, Akiko Kawasaki, SUZUKI Kazuomi, Takashi Matsuo and EBISU Shigeyuki :
Comparison of dentinal tubules occlusion-CPP, Resin and Potassium Oxalate,
Journal of Dental Research, Vol.77, No.Special Issue, 651, Nice, Jun. 1998. Shigeyuki Ebisu, T Yasunaga, Toshiyuki Suge, Akiko Kawasaki, Kunio Ishikawa, Kenzo Asaoka and Takashi Matsuo :
Acid resistance of bovine enamel after calcium phosphate precipitation method using dogs,
Journal of Dental Research, Vol.76, No.Special Issue, 180, Orlando, Mar. 1997. Akiko Kawasaki, Kunio Ishikawa, Toshiyuki Suge, Kenzo Asaoka, Takashi Matsuo and Shigeyuki Ebisu :
Effects of plaque control on the occlusion of dentin tubules,
Journal of Dental Research, Vol.76, No.Special Issue, 180, Orlando, Mar. 1997. Toshiyuki Suge, Kunio Ishikawa, Akiko Kawasaki, Kenzo Asaoka, Takashi Matsuo and Shigeyuki Ebisu :
Acid resistance of bovine enamel after calcium phosphate precipitation method,
Journal of Dental Research, Vol.76, No.Special Issue, 97, Orlando, Mar. 1997. Toshiyuki Suge, Kunio Ishikawa, Akiko Kawasaki, Masahiro Yoshiyama, Kenzo Asaoka and Shigeyuki Ebisu :
Calcium phosphate precipitation method using buffer for post-treatment solution,
Journal of Dental Research, Vol.75, No.Special Issue, 279, San Francisco, Mar. 1996. Akiko Kawasaki, Kunio Ishikawa, Toshiyuki Suge, Masahiro Yoshiyama, Kenzo Asaoka and Shigeyuki Ebisu :
Effects of calcium phosophate precipitation method on crystalinity of apatite,
Journal of Dental Research, Vol.75, No.Special Issue, 279, San Francisco, Mar. 1996. Toshiyuki Suge, Kunio Ishikawa, Akiko Kawasaki, Masahiro Yoshiyama, Kenzo Asaoka and Shigeyuki Ebisu :
Duration of calcium phosphate precipitation method for dentinal tubules occlusion,
Journal of Dental Research, Vol.74, No.Special Issue, 423, Singapore, Jun. 1995. Akiko Kawasaki, Kunio Ishikawa, Toshiyuki Suge, Masahiro Yoshiyama, Kenzo Asaoka and Shigeyuki Ebisu :
Effecs of fluoride on CPP method for dentin hypersensitivity treatment,
Journal of Dental Research, Vol.74, No.Special Issue, 423, Singapore, Jun. 1995. 菅俊行, 野口直人, 松尾敬志, 吉本勝彦, 市川哲雄 :
日本大学松戸歯学部臨床実習視察報告,
第42回四国歯学会例会, 2013年3月. 竹内久裕, 菅俊行, 桃田幸弘, 尾崎和美, 中道敦子, 三宅洋一郎, 吉本勝彦, 市川哲雄 :
日本歯科大学臨床実習視察報告,
第38回四国歯学会例会, 2011年3月. 菅俊行, 川﨑有希子, 松尾敬志, 石川邦夫, 恵比須繁之 :
フッ化ジアミンシリケートの象牙細管封鎖効果の持続性およびアパタイト誘導能の評価,
日本歯科保存学雑誌, Vol.47, 100, 2004年11月. 菅俊行, 川﨑有希子, 尾崎和美, 松尾敬志, 石川邦夫, 恵比須繁之 :
フッ化ジアミンシリケートによる歯質耐酸性の向上効果,
第118回日本歯科保存学会春季学会, 2003年6月. 末延慎司, 尾崎和美, 位田夏子, 川﨑有希子, 菅俊行, 松尾敬志 :
銀担持シリカを添加した合着用グラスアイオノマーセメントの諸性質,
第115回秋季日本歯科保存学会, 2001年11月. 菅俊行, 川﨑有希子, 松尾敬志, 石川邦夫, 鈴木一臣, 恵比須繁之 :
フッ化ジアミンシリケートによる象牙質知覚過敏賞の治療法, --- 象牙細管封鎖効果の評価 ---,
日本歯科保存学雑誌, Vol.44, 114, 2001年6月. 菅俊行, 川﨑有希子, 松尾敬志, 石川邦夫, 鈴木一臣, 恵比須繁之 :
シュウ酸カリウム処理法への塩化カルシウム添加効果,
日本歯科保存学雑誌, Vol.43, 102, 2000年4月. 藤中恵子, 吉田佳子, 松岡希実, 川﨑有希子, 菅俊行, 松尾敬志 :
難知性根尖性歯周炎における根尖部の細菌侵襲の実態,
日本歯科保存学雑誌, Vol.42, 57, 1999年11月. 菅俊行, 石川邦夫, 川﨑有希子, 鈴木一臣, 松尾敬志, 恵比須繁之 :
アパタイト析出法による象牙質知覚過敏症の治療法,
四国歯学会雑誌, 1998年6月. 松岡希実, 吉田佳子, 川﨑有希子, 菅俊行, 野杁由一郎, 松尾敬志 :
ヒト感染根管の根尖部に認められた細菌の免疫組織学的解析,
日本歯科保存学雑誌, Vol.41, 71, 1998年6月. 川﨑有希子, 菅俊行, 松尾敬志, 石川邦夫, 恵比須繁之 :
アパタイト析出法がエナメル質の結晶性および耐酸性におよぼす影響について,
日本歯科保存学雑誌, Vol.39, 118, 1997年6月. Akiko Kawasaki, Kunio Ishikawa, Toshiyuki Suge, Kenzo Asaoka, Takashi Matsuo and Shigeyuki Ebisu :
Effect of apatite forming method on the crystallinity of hydroxyapatite powder,
Transaction of the 12 th Symposium on apatite, 6-7, Dec. 1996. Toshiyuki Suge, Kunio Ishikawa, Akiko Kawasaki, Kenzo Asaoka, Takashi Matsuo and Shigeyuki Ebisu :
Apatite forming method -duration of dentinal tubules occlusion-,
Transactions of the 12th Symposium on apatite, 4-5, Dec. 1996. Toshiyuki Suge, Kunio Ishikawa, Akiko Kawasaki, Kenzo Asaoka, Takashi Matsuo and Shigeyuki Ebisu :
A new treatment method for dentin hypersensitivity -apatite forming method-,
Transactions of the 12th Symposium on apatite, 2-3, Dec. 1996. 菅俊行, 川﨑有希子, 野杁由一郎, 石川邦夫, 恵比須繁之 :
アパタイト析出法による象牙質知覚過敏症の治療法, --- ビーグル犬における象牙細管封鎖効果 ---,
日本歯科保存学雑誌, Vol.39, 118, 1996年3月. 菅俊行, 吉山昌宏, 川﨑有希子, 恵比須繁之 :
アパタイト析出法による象牙質知覚過敏症の治療法, --- 臨床応用に適した後処理液の検討 ---,
日本歯科保存学雑誌, Vol.38, 160, 1995年10月. 川﨑有希子, 菅俊行, 清水洋利, 吉山昌宏, 恵比須繁之 :
プラークコントロールが歯根部象牙質知覚過敏賞の自然治癒機構に及ぼす効果について,
日本歯科保存学雑誌, Vol.38, 17, 1995年6月. 川﨑有希子, 石川邦夫, 菅俊行, 吉山昌宏, 恵比須繁之 :
アパタイト析出法による象牙細管封鎖におけるケイフッ化カルシウムの添加効果,
日本歯科保存学雑誌, Vol.37, 69, 1994年11月. 菅俊行, 石川邦夫, 川﨑有希子, 吉山昌宏, 恵比須繁之 :
アパタイト析出法を利用した象牙質知覚過敏症の治療法, --- 象牙細管封鎖効果の経時的変化 ---,
日本歯科保存学雑誌, Vol.37, 67, 1994年5月. 吉山昌宏, 菅俊行, 川﨑有希子, 恵比須繁之 :
プライマー処理による歯頚部磨耗象牙質の微細形態学的変化,
日本歯科保存学雑誌, Vol.36, 131, 1993年11月. 川﨑有希子, 菅俊行, 吉山昌宏, 恵比須繁之 :
知覚過敏を発症した歯根面象牙質の超微構造,
日本歯科保存学雑誌, Vol.36, 168, 1993年11月. 菅俊行, 大木元玲子, 川﨑有希子, 吉山昌宏, 恵比須繁之 :
アパタイト析出法を利用した象牙質知覚過敏症の治療法, --- フッ素添加効果の検討 ---,
日本歯科保存学雑誌, Vol.36, 23, 1993年11月. 菅俊行, 川﨑有希子, 吉山昌宏, 恵比須繁之, 石川邦夫 :
象牙質知覚過敏症の治療法, --- アパタイト析出法による in vivo での象牙細管封鎖効果 ---,
日本歯科保存学雑誌, Vol.36, 44, 1993年6月. 吉山昌宏, 菅俊行, 川﨑有希子, 恵比須繁之 :
象牙質知覚過敏症の発症機構における突起様構造物の役割,
日本歯科保存学雑誌, Vol.35, 16, 1992年11月. 吉山昌宏, 菅俊行, 恵比須繁之 :
象牙質知覚過敏症の発症機構, --- 突起様構造物の検索 ---,
日本歯科保存学雑誌, Vol.35, 27, 1992年6月. 吉山昌宏, 菅俊行, 白神俊之, 尾崎和美, 恵比須繁之 :
象牙質知覚過敏症の発症機構, --- 塩酸コラゲナーゼ消化した象牙質生検試料の走査電顕的検討 ---,
硬組織研究技術談話会, 1992年3月. 吉山昌宏, 菅俊行, 尾崎和美, 恵比須繁之 :
象牙質知覚過敏症の発症機構, --- レジンライナー塗布法による有効例および無効例の微細形態学的検討 ---,
第95回日本歯科保存学会秋季学会, 1991年11月.

研究会・報告書

竹内久裕, 菅俊行, 桃田幸弘, 尾崎和美, 中道敦子, 三宅洋一郎, 吉本勝彦, 市川哲雄 :
日本歯科大学臨床実習視察報告,
四国歯学会雑誌, Vol.24, No.2, 85-94, 2012年1月.

(徳島大学機関リポジトリ): ● Metadata: 109821

(徳島大学機関リポジトリ: 109821) 菅俊行, 野口直人, 松尾敬志, 吉本勝彦, 市川哲雄 :
日本大学松戸歯学部臨床実習視察報告,
四国歯学会雑誌, Vol.26, No.2, 81-89, 徳島, 2014年2月.

(徳島大学機関リポジトリ): ● Metadata: 109848

(徳島大学機関リポジトリ: 109848)

特許: 研究者総覧に該当データはありませんでした。
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補助金・競争的資金: 訪問・在宅に向けた新しい概念の保存治療法の開発―高周波/電磁波などを応用して― (研究課題/領域番号: 17K11708 )
抗菌性フッ化ジアミンシリケート溶液の根面齲蝕予防剤への臨床応用 (研究課題/領域番号: 16K11553 )
抗菌成分添加フッ化ジアミンシリケートの齲蝕および酸蝕歯への臨床応用 (研究課題/領域番号: 25462961 )
ミニマムインターベンションの概念と齲蝕病態に基づく新規の包括的齲蝕治療法の開発 (研究課題/領域番号: 23390435 )
抗菌成分添加フッ化ジアミンシリケートを利用した齲蝕予防剤の開発 (研究課題/領域番号: 22592121 )
根面齲蝕の病態・病因の解析に基づく新しい診断法と治療法の開発 (研究課題/領域番号: 20592229 )
象牙質齲蝕侵入細菌におけるクオラムセンシング機構の実態の解明 (研究課題/領域番号: 19592204 )
フッ化ジアミンシリケートによる齲蝕予防と象牙質知覚過敏症治療剤への臨床応用 (研究課題/領域番号: 19592203 )
歯周病変特異的に発現するクローディンによる歯周病原因子の上皮透過性制御機構の解明 (研究課題/領域番号: 18592264 )
シリカーフッ素化合物を利用した齲蝕予防および象牙質知覚過敏症治療法の開発 (研究課題/領域番号: 16591916 )
フッ化ジアミンシリケートによる齲蝕予防と象牙質知覚過敏症治療に関する研究 (研究課題/領域番号: 13672002 )
歯髄組織破壊における炎症性細胞浸潤とケモカインの役割に関する研究 (研究課題/領域番号: 13672001 )
露髄部の細菌-宿主関係からみた歯髄組織破壊機構の解析 (研究課題/領域番号: 11671897 )
アパタイト析出法による歯質強化機構の解明 (研究課題/領域番号: 09771622 )
接着修復手法に及ぼす象牙質歯髄複合体の病態生理の影響 (研究課題/領域番号: 09671956 )
アパタイト析出法による象牙質知覚過敏症治療の臨床応用への展開 (研究課題/領域番号: 09557152 )
象牙質病態のレジン接着に及ぼす影響 (研究課題/領域番号: 08672195 )
アパタイト析出法による象牙細管封鎖効果の持続性 (研究課題/領域番号: 07771762 )
アパタイト析出法による象牙質知覚過敏症の治療法の開発 (研究課題/領域番号: 07557271 )
アパタイト析出法を利用した象牙質知覚過敏症の治療法に関する研究 (研究課題/領域番号: 06771718 )
歯根面知覚過敏症における自然治癒機構の解析 (研究課題/領域番号: 06671917 )
露出象牙質の微細形態を考慮した歯頚部磨耗症の治療法に関する研究 (研究課題/領域番号: 05857216 )
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2024年12月20日更新

専門分野・研究分野: 歯科保存学 (Conservative Dentistry)
所属学会・所属協会: 日本歯科保存学会
国際歯科研究学会
日本歯科理工学会
四国歯学会
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Jグローバル最終確認日: 2024/12/21 01:22
氏名（漢字）: 菅俊行
氏名（フリガナ）: スゲトシユキ
氏名（英字）: Suge Toshiyuki
所属機関: 徳島大学講師

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researchmap最終確認日: 2024/12/22 01:38
氏名（漢字）: 菅俊行
氏名（フリガナ）: スゲトシユキ
氏名（英字）: Suge Toshiyuki
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登録日時: 2007/12/21 00:00
更新日時: 2024/12/18 10:28
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所属ID: 0344007001
所属: 徳島大学
部署: 歯学部歯学科
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学位: 博士(歯学)
学位授与機関: 大阪大学
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研究者番号: 60243713

所属（現在）: 2024/4/1 : 徳島大学, 病院, 講師

所属（過去の研究課題 情報に基づく）*注記: 2016/4/1 – 2019/4/1 : 徳島大学, 病院, 講師
2012/4/1 – 2015/4/1 : 徳島大学, 大学病院, 講師
2010/4/1 – 2013/4/1 : 徳島大学, 病院, 講師
2009/4/1 : 徳島大学, 医学部・歯学部・附属病院, 講師
2007/4/1 – 2009/4/1 : 徳島大学, 医学部・歯学部附属病院, 講師
2006/4/1 : 徳島大学, 大学院ヘルスバイオサイエンス研究部, 助手
2004/4/1 – 2005/4/1 : 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助手
1993/4/1 – 2002/4/1 : 徳島大学, 歯学部, 助手
1996/4/1 : 徳島大学, 歯学部・附属病院, 助手
1996/4/1 : 徳島大学, 歯学部附属病院, 助手

審査区分/研究分野

研究代表者

医学 / 歯学 / 保存治療系歯学
生物系 / 医歯薬学 / 歯学 / 保存治療系歯学

研究代表者以外

医学 / 歯学 / 保存治療系歯学
生物系 / 医歯薬学 / 歯学 / 保存治療系歯学
生物系 / 医歯薬学 / 歯学 / 歯周治療系歯学

キーワード

研究代表者

歯頚部磨耗症 / 象牙細管 / 走査型電子顕微鏡 / プライマー / 象牙質知覚過敏症 / アパタイト / フッ素 / X線微小分析 / 粉末X線回折 / フーリエ変換赤外線分光法 / 人工唾液 / エナメル質 / リン酸カルシウム / フッ化ナトリウム / 脱灰 / 結晶性 / 耐酸性 / 表面粗さ測定機 / 齲蝕 / フッ化ジアミンシリケート / シリカ / フッ化ジアンミン銀 / フッ化カルシウム / 抗菌成分 / スメア層 / ハイドロキシアパタイト / 塩化セチルピリジニウム / 粉末Ｘ線回折 / 齲蝕予防 / S. mutans / 酸蝕症 / 歯学 / サホライド / 抗菌性 / 酸蝕歯 / グルコン酸クロルヘキシジン / 象牙質 / 牛歯 / マイクロラジオグラフィー / 表面粗さ測定器 / 象牙質透過性 / 走査電子顕微鏡 / Demineralization / Bovine tooth / Ammonium hexafluorosilicate / Dental caries / Microradiography / Diamine silver fluoride / Fluoride / Dentin hypersensitivity / イヌ生活歯 / 操作型電子顕微鏡 / 象牙細管内液 / ammonium hexafluorosilicate / diamine silver fluoride / fluoride / dentin hypersensitivity / dental caries / silica / calcium phosphate / dentin tubule / う蝕

研究代表者以外

象牙質知覚過敏症 / プラークコントロール / 象牙細管 / 象牙質生検試料 / 象牙質 / 齲蝕症 / 歯頚部磨耗症 / 接着性レジン / 樹脂含浸層 / レジン浸透性 / 歯髄象牙質複合体 / 象牙質齲蝕 / 齲蝕原性細菌 / バイオフィルム / クオラムセンシング / 根面齲蝕 / ミュータンス菌 / 再石灰化 / 歯髄炎 / カテキン / 象牙細管侵入細菌 / 歯髄応答 / 自然免疫 / 病原体特異的分子パターン / パターン認識受容体 / 茶カテキン / 自然免疫機構 / 齲蝕 / ミニマムインターベンション / 高周波/電磁波 / アンモニウムヘクサフルオロシリケート / 齲蝕治療法 / ミニマルインターベンション / 象牙質再石灰化法 / 電磁波/高周波 / 自然免疫応答 / ミニマルインターベンション（MI） / フッ化ジアミンシリケート / ポリフェノール / 封鎖 / アパタイト / ビ-グル犬 / 走査型電子顕微鏡 / Dentin hypersensitivity / Dentinal tubules / Occlusion / Apatite / Dog / リン酸カルシウム / ビーグル犬 / ピーグル犬 / シュウ酸カリウム / Calcium phosphate / Beagle dog / Scanning electron microscopy / Plaque control / 象牙質歯髄複合体 / Dentin / pulp complex / Resin permeability / Hybrid layer / Adhesive resin / う蝕関連細菌 / 免疫染色 / マクロファージ / 線維芽細胞 / cyclooxygenase-2 / MCP-1 / MMP-1 / シクロオキシゲナーゼ-2 / Caries-associated bacteria / Pulpitis / Immunohistology / Macrophage / Fibroblast / Cyclooxygenase-2 / MIP-3α / CCR6 / 内皮細胞 / リンパ球 / ケモカイン / ケモカインレセプター / RT-PCR / ELISA / Streptococcus mutans / IL-1β / TNF-α / CD45RO / pulpitis / macrophage / endothelial cell / lymphocyte / chemokine / chemokine receptor / tight junction / adherence junction / claudin / cadherin / JAM-A / 上皮細胞 / 歯周病 / MMP / タイトジャンクション / クローディン / 共培養 / tight-junction / トランスフェクション / fight iunction / epithelial cell / periodontal disease / う蝕治療 / 初期歯髄炎 / 在宅・訪問診療 / 深在性う蝕 / 訪問・在宅治療 / 在宅・訪問歯科治 / 齲蝕治療 / 健康寿命 / 在宅・訪問歯科治療 / 高周波/電磁波治療

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