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柏田良樹

徳島大学

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2024年11月15日更新

職名: 名誉教授 (2022.4)
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学歴: 1981/3: 徳島大学大学院薬学研究科修士課程修了
1984/2: 九州大学大学院薬学研究科薬学専攻博士後期課程中退
学位: 薬学博士 (九州大学) (1989年3月)
職歴・経歴: 1984/3: 九州大学薬学部教務員
1984/4: 九州大学薬学部助手
1991/9: ノースカロライナ大学薬学部・Research Assistant Professor
1992/9: ノースカロライナ大学薬学部・Research Associate Professor
1995/4: 新潟薬科大学薬学部・助教授
2006/4: 徳島大学助教授，大学院ヘルスバイオサイエンス研究部
2007/4: 徳島大学准教授，大学院ヘルスバイオサイエンス研究部
2013/4: 徳島大学教授，大学院ヘルスバイオサイエンス研究部
2015/4: 徳島大学教授, 大学院医歯薬学研究部

専門分野・研究分野: 天然物化学 (Natural Products Chemistry)
生薬学 (Pharmacognosy)

研究者総覧で最新データを確認する

2024年11月15日更新

専門分野・研究分野: 天然物化学 (Natural Products Chemistry)
生薬学 (Pharmacognosy)
担当経験のある授業科目: 研究者総覧に該当データはありませんでした。
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研究者総覧で最新データを確認する

2024年11月15日更新

専門分野・研究分野: 天然物化学 (Natural Products Chemistry)
生薬学 (Pharmacognosy)

研究テーマ: 抗HIV天然物に関する研究, 抗腫瘍活性天然物に関する研究

著書

石黒京子, 伊藤美千穂, 井上誠, 内田龍児, 梅垣敬三, 大島吉輝, 大城太一, 太田富久, 岡村信幸, 奥山恵美, 柏田良樹, 木内文之, 木下武司, 合田幸広, 小林資正, 小松かつ子, 小山清隆, 小山信裕, 酒井英二, 渋谷雅明, 白瀧義明, 高山廣光, 田中隆, 谷口雅彦, 供田洋, 永津明人, 野口博司, 羽田紀康, 波多野力, 藤井勲, 伏見裕利, 船山信次, 松田久司, 三巻祥浩, 森田博史, 吉松嘉代 :
化学系薬学 Ⅲ. 自然が生み出す薬物,
株式会社東京化学同人, 2016年10月. 福井裕行, 水口博之, 柏田良樹, 根本尚夫, 北村嘉章, 武田憲昭 :
抗アレルギー天然物医薬，苦参の有効成分，(-)マーキアインの分子薬理機構,
公益社団法人日本薬理学会, 2016年3月.

(要約): ヒスタミンH1受容体には，受容体刺激による遺伝子発現亢進を介する受容体アップレギュレーション機構が存在することを見いだし，タンパク質キナーゼC-δ(PKCδ)活性化を介することを明らかにした．臨床研究により，この機構が花粉症の鼻過敏症状悪化に関与し，ヒスタミンH1受容体遺伝子が疾患感受性遺伝子であることが示唆された．鼻過敏症モデルラットに対する抗ヒスタミン薬および抗アレルギー天然物医薬である苦参エキスの投与は，共に鼻過敏症状の改善とそれに相関した鼻粘膜ヒスタミンH1受容体mRNAレベル上昇の抑制を引き起こした．苦参エキスに含まれるヒスタミンH1受容体遺伝子発現抑制物質として(-)マーキアインを同定し，鼻過敏症モデルラットの鼻過敏症状に対する改善作用を明らかにした．(-)マーキアインの作用点がPKCδ活性化抑制であり，標的分子としてヒートショックタンパク質-90(Hsp90)の同定に成功した．Hsp90とPKCδは複合体を形成し，(-)マーキアインは複合体を解離させることにより，PKCδシグナルを核に伝えないと考えられた．さらに，Hsp90抑制薬が，鼻過敏症モデルラットの鼻過敏症状および鼻粘膜ヒスタミンH1受容体遺伝子発現亢進に対する改善作用を示した．以上の結果より，ヒスタミンH1受容体遺伝子が花粉症の感受性遺伝子であり，抗ヒスタミン薬はH1受容体のレベルで，苦参エキスはPKCδのレベルで改善作用を発揮することが示唆された．
(キーワード): 鼻過敏症 / 疾患感受性遺伝子 / 天然物医薬 / タンパク質キナーゼC-δ(PKCδ) / ヒートショックタンパク質-90(Hsp90)
(出版サイトへのリンク): ● Publication site (DOI): 10.1254/fpj.147.148
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26960774; ● CiNii @ 国立情報学研究所 (CRID): 1390282679250969088; ● Search Scopus @ Elsevier (PMID): 26960774; ● Search Scopus @ Elsevier (DOI): 10.1254/fpj.147.148

(DOI: 10.1254/fpj.147.148, PubMed: 26960774, CiNii: 1390282679250969088) Hiroyuki Fukui, Hiroyuki Mizuguchi, Hisao Nemoto, Yoshiaki Kitamura, Yoshiki Kashiwada and Noriaki Takeda :
Histamine H1 receptor gene expression and drug action of antihistamines.,
Springer Science, NewYork, 2016. 柏田良樹, 金田幸, 北中進, 斉藤節生, 白瀧義明, 袴塚高志, 船山信次, 細井信造, 三巻祥浩, 横江一朗 :
医療を指向する天然医薬品化学,
株式会社廣川書店, 東京, 2005年3月.

論文

Rena Takizawa, Tomoyo Minamizono, Daisuke Tsuji, Yan Xiao-Jie, Lu Feng-Lai, Yang Xue-Rong, Li Dian-Peng, Akagi Reiko, Yoshiki Kashiwada and Naonobu Tanaka :
Methoxyflavone glucosides and caffeoyl phenylethanoid glycoside from Lysionotus pauciflorus: their structures and antiferroptosis activity,
Journal of Natural Medicines, 2024.

(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s11418-024-01851-w
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1007/s11418-024-01851-w

(DOI: 10.1007/s11418-024-01851-w) Rena Takizawa, Yusei Shimomoto, Daisuke Tsuji, Kiyoshi Imabayashi, Kohji Itoh, Reiko Akagi, Yoshiki Kashiwada and Naonobu Tanaka :
Formohyperins G-L, polycyclic prenylated benzoylphloroglucinols from the flowers of Hypericum formosanum,
Journal of Natural Medicines, Vol.78, No.4, 970-977, 2024.

(要約): Phytochemical study on the flowers of Hypericum formosanum Maxim. (Hypericaceae) led to the isolation of formohyperins G-L (1-6), whose structures were assigned by detailed spectroscopic analysis. Formohyperins G-L (1-6) are new benzoylphloroglucinols substituted by a C unit, a prenyl group, and a methyl group. Formohyperins G-J (1-4) possess a 6/6/6-tricyclic structure, while formohyperins K (5) and L (6) have a unique 6/6/5/4-tetracyclic structure consisting of cyclohexadienone, dihydropyrane, cyclopentane, and cyclobutane rings. The absolute configurations of 1-6 were deduced by analysis of the ECD spectra. Formohyperins G-J (1-4) and L (6) were found to show potent inhibitory activities against IL-1β release from LPS-treated murine microglial cells with EC values of 5.0, 10.9, 6.3, 10.8, and 13.7 µM, respectively, without cytotoxicity. 6-O-Methylformohyperins G (1a) and I (3a) also exhibited the inhibitory activities with EC values of 4.7 and 2.7 µM, respectively, although they were cytotoxic against microglial cells.
(キーワード): Hypericum / Animals / Phloroglucinol / Flowers / Mice / Molecular Structure / Interleukin-1beta / Microglia / Prenylation / Plant Extracts / Lipopolysaccharides / Cell Line
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s11418-024-01839-6
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 39126611; ● Summary page in Scopus @ Elsevier: 2-s2.0-85200964791

(DOI: 10.1007/s11418-024-01839-6, PubMed: 39126611, Elsevier: Scopus) Yoshino Yuki, Masaki Imanishi, Licht Miyamoto, Daisuke Tsuji, Akagi Reiko, Koichiro Tsuchiya, Yoshiki Kashiwada and Naonobu Tanaka :
Dauferulins A-L, daucane-type sesquiterpenes from the roots of Ferula communis: Their structures and biological activities,
Fitoterapia, Vol.174, 105877, 2024.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.fitote.2024.105877
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1016/j.fitote.2024.105877

(DOI: 10.1016/j.fitote.2024.105877) Naonobu Tanaka, Rena Takizawa, Yusei Shimomoto, Daisuke Tsuji, Koji Yonekura, Kohji Itoh, Reiko Akagi and Yoshiki Kashiwada :
Meroterpenes and prenylated benzoylphloroglucinol from the flowers of Hypericum formosanum,
Phytochemistry, Vol.220, 114016, 2024.

(要約): Formohyperins A-F, previously undescribed meroterpenes, and grandone, a prenylated benzoylphloroglucinol being considered to be one of their biogenetic precursors, were isolated from the flowers of a Hypericaceous plant, Hypericum formosanum Maxim. Detailed spectroscopic analyses showed that formohyperins A-D were meroterpenes with an enolized 3-phenylpropane-1,3-dione moiety. Formohyperins E and F were elucidated as meroterpenes having a 4-benzoyl-5-hydroxycyclopent-4-ene-1,3-dione moiety. Formohyperins A-C and E were optically active, and their absolute configurations were deduced by comparison of the experimental and TDDFT calculated ECD spectra. In contrast, formohyperin D was concluded to be a racemate. Formohyperins A-F and grandone were found to show inhibitory activities against LPS-stimulated IL-1β production from murine microglial cells with EC values of 13.2, 6.6, 8.5, 24.3, 4.1, 10.9, and 3.0 μM, respectively.
(キーワード): Mice / Animals / Phloroglucinol / Hypericum / Flowers / Microglia / Prenylation / Molecular Structure
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.phytochem.2024.114016
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38364882; ● Summary page in Scopus @ Elsevier: 2-s2.0-85185371382

(DOI: 10.1016/j.phytochem.2024.114016, PubMed: 38364882, Elsevier: Scopus) Naonobu Tanaka, Itsukoh Shibata, Yusuke Tasaki, Yuki Yoshino, Daisuke Tsuji, Lu Fen-Lai, Yang Xia-Jie, Yang Xue-Rong, Kouji Itou, Akagi Reiko and Yoshiki Kashiwada :
Acylated iridoid glucoside and xanthones from Canscora lucidissima: Their structures and ferroptosis inhibitory activity,
Fitoterapia, Vol.168, 105539, 2023.

(要約): Phytochemical study on the whole plants of a Gentianaceous medicinal plant, Canscora lucidissima, gave one new acylated iridoid glucoside, canscorin A (1), and two new xanthone glycosides (2 and 3) together with 17 known compounds including five xanthones, eight xanthone glycosides, two benzophenone glucosides, caffeic acid, and loganic acid. Canscorin A (1) was assigned as a loganic acid derivative having a hydroxyterephthalic acid moiety by spectroscopic analysis together with chemical evidence, while 2 and 3 were elucidated to be a rutinosylxanthone and a glucosylxanthone, respectively. The absolute configurations of the sugar moieties of 2 and 3 were determined by HPLC analysis. The isolated compounds were evaluated for their inhibitory activities against erastin-induced ferroptosis on human hepatoma Hep3B cells and LPS-stimulated IL-1β production from murine microglial cells.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.fitote.2023.105539
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37178810; ● Search Scopus @ Elsevier (PMID): 37178810; ● Search Scopus @ Elsevier (DOI): 10.1016/j.fitote.2023.105539

(DOI: 10.1016/j.fitote.2023.105539, PubMed: 37178810) Yuki Yoshino, Naonobu Tanaka, Daisuke Tsuji, Kouji Itou and Yoshiki Kashiwada :
Communiferulins, farnesylated coumarins from the roots of Ferula communis and their anti-neuroinflammatory activity,
Journal of Natural Medicines, Vol.77, No.1, 173-179, 2023.

(要約): Three new farnesylated coumarins, communiferulins A-C (1-3), and a farnesylated chromone, ferchromone (4), were isolated from the roots of an Apiaceous plant Ferula communis. Their structures including the relative configurations were elucidated by a combination of spectroscopic analyses and calculations of the NMR data. Communiferulins A-C (1-3) had dihydrofuran rings fused to C-3 and C-4 of their coumarin moieties, while 3 possessed one additional furan ring. HPLC analyses using a chiral column showed 1-4 to be racemates, and the absolute configurations of (+)-1, (-)-1, (+)-2, and (-)-2 were deduced by comparison of their ECD spectra with TDDFT-calculated spectra. Communiferulins A (1) and B (2), and ferchromone (4) showed inhibitory activities on IL-1β production from LPS-stimulated microglial cells.
(キーワード): Ferula / 分子構造 (molecular structure) / Plant Extracts / Magnetic Resonance Spectroscopy / Coumarins / Plant Roots
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s11418-022-01657-8
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36289185; ● Summary page in Scopus @ Elsevier: 2-s2.0-85140649347

(DOI: 10.1007/s11418-022-01657-8, PubMed: 36289185, Elsevier: Scopus) Naonobu Tanaka, TAKAHASHI Sakura, Yuki Yoshino, Nakatani Megumi, Ahmed Ali Fakhruddin, Hossain Mosharof Gazi, Chen Chin-Ho, Lee Kuo-Hsiung and Yoshiki Kashiwada :
Tigliane-type diterpene esters from the fruits of Shirakiopsis indica and their anti-HIV activity,
Journal of Natural Products, 2022.

(出版サイトへのリンク): ● Publication site (DOI): 10.1021/acs.jnatprod.2c00752
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1021/acs.jnatprod.2c00752

(DOI: 10.1021/acs.jnatprod.2c00752) Xuerong Yang, Naonobu Tanaka, Song Jing-Ru, Lu Feng-Lai, Yan Xiao-Jie, Li Jian-Xing, Zhao Xue-Ying, Yoshiki Kashiwada and Li Dian-Peng :
Rhodomollosides A and B, glycosides of methyl everninate from the aerial parts of Rhododendron molle,
Journal of Asian Natural Products Research, Vol.24, No.11, 1025-1032, 2022.

(出版サイトへのリンク): ● Publication site (DOI): 10.1080/10286020.2021.2011241
(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-85121788704

(DOI: 10.1080/10286020.2021.2011241, Elsevier: Scopus) Shaha Aurpita, Islam Rezwanul, Naonobu Tanaka, Yoshiki Kashiwada, Hiroyuki Fukui, Noriaki Takeda, Yoshiaki Kitamura and Hiroyuki Mizuguchi :
Betuletol, a propolis component, suppresses IL-33 gene expression and effective against eosinophilia,
Molecules, Vol.27, No.17, 5459, 2022.

(要約): Propolis, a resinous substance produced by honeybees, has been used in folk medicine since ancient times due to its many biological benefits such as antitumor, antioxidant, antimicrobial, anti-inflammatory, and immunomodulatory effects. Propolis contains flavonoids, terpenoids, aromatic aldehydes, and alcohols, which vary with different climate and environmental conditions. In our study, we examined the antiallergic activity of Brazilian green propolis (BGP) and isolated the active compound that can suppress an allergy-sensitive gene, IL-33, expression and eosinophilia. Ethanolic extract of BGP freeze-dried powder was fractionated with several solvent systems, and the active fractions were collected based on activity measurement. The single active compound was found by thin-layer chromatography. Using column chromatography and NMR, the active compound was isolated and identified as 3,5,7-trihydroxy-6,4'-dimethoxyflavone, also known as betuletol. Further, the antiallergic activity of that has been examined in PMA-induced up-regulation of IL-33 gene expression in Swiss 3T3 cells. Our data showed the IL-33 gene suppression both by BGP and the isolated active compound, betuletol. We also found that betuletol suppressed ERK phosphorylation, suggesting it could be effective in suppressing IL-33 mediated eosinophilic chronic inflammation and will provide new insights to develop potent therapeutics against allergic inflammations.
(キーワード): Animals / Anti-Allergic Agents / Eosinophilia / Gene Expression / Inflammation / Interleukin-33 / Mice / Propolis
(徳島大学機関リポジトリ): ● Metadata: 117847
(出版サイトへのリンク): ● Publication site (DOI): 10.3390/molecules27175459
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36080225; ● Summary page in Scopus @ Elsevier: 2-s2.0-85137579924

(徳島大学機関リポジトリ: 117847, DOI: 10.3390/molecules27175459, PubMed: 36080225, Elsevier: Scopus) Yasumasa Ikeda, Masafumi Funamoto, Seiji Kishi, Masaki Imanishi, Ken-ichi Aihara, Yoshiki Kashiwada and Koichiro Tsuchiya :
The novel preventive effect of a Japanese ethical Kampo extract formulation TJ-90 (Seihaito) against cisplatin-induced nephrotoxicity,
Phytomedicine, Vol.103, No.8, 154213, 2022.

(徳島大学機関リポジトリ): ● Metadata: 117134
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.phymed.2022.154213
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1016/j.phymed.2022.154213

(徳島大学機関リポジトリ: 117134, DOI: 10.1016/j.phymed.2022.154213) Naonobu Tanaka, Yuki Yoshino, Fusako Nakano, Shin-ichiro Kurimoto, Kazuyoshi Kawazoe, Daisuke Tsuji, Kouji Itou, Shun-Lin Li, Han-Dong Sun, Yoshihisa Takaishi and Yoshiki Kashiwada :
Lanicepines A and B, sesquiterpenes with amino acid-derived substituents from the flowering aerial parts of Saussurea laniceps,
Journal of Natural Products, Vol.85, No.4, 1180-1185, 2022.

(出版サイトへのリンク): ● Publication site (DOI): 10.1021/acs.jnatprod.1c01069
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1021/acs.jnatprod.1c01069

(DOI: 10.1021/acs.jnatprod.1c01069) Kanji Niwa, Naonobu Tanaka, Shimomoto Yusei, Daisuke Tsuji, Kim Sang-Yong, Kojoma Mareshige, Kouji Itou, Chen Chin-Ho, Lee Kuo-Hsing and Yoshiki Kashiwada :
Hyperdioxanes, dibenzo-1,4-dioxane derivatives from the roots of Hypericum ascyron,
Journal of Natural Medicines, Vol.75, No.4, 907-914, 2021.

(要約): Six dibenzo-1,4-dioxane derivatives (1-6) were isolated from the roots of a Hypericaceous plant Hypericum ascyron. Spectroscopic analyses revealed 2 and 4-6 to be new compounds. The partial racemic natures of 1-3 were concluded by chiral HPLC analyses, while 5 was confirmed to be a racemate. The absolute configurations 1-4 were deduced on the basis of ECD calculations. Biological activity evaluation of the dibenzo-1,4-dioxane derivatives along with two related compounds: hyperdioxanes A (7) and B (8), previously isolated from the same plant material by our group demonstrated that 7 exhibit an anti-HIV activity (IC 5.3 μM, TI 7.2) while 8 showed an inhibitory effect on IL-1β production (inhibition rate: 72.3% at 6.3 μM) from LPS-stimulated microglial cells.
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s11418-021-01540-y
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34142303; ● Search Scopus @ Elsevier (PMID): 34142303; ● Search Scopus @ Elsevier (DOI): 10.1007/s11418-021-01540-y

(DOI: 10.1007/s11418-021-01540-y, PubMed: 34142303) Naonobu Tanaka, Amuti Saidanxia, Sakura Takahashi, Daisuke Tsuji, Kouji Itou and Yoshiki Kashiwada :
Studies on non-medicinal parts of plant materials: Triterpenes from the roots of Schisandra chinensis,
Fitoterapia, Vol.152, 104939, 2021.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.fitote.2021.104939
(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-85106474288

(DOI: 10.1016/j.fitote.2021.104939, Elsevier: Scopus) Kohta Yamasaki, Akiho Yamauchi, Tsubasa Inokuma, Yasunori Miyakawa, Yinli Wang, Raphaël Oriez, Yousuke Yamaoka, Kiyosei Takasu, Naonobu Tanaka, Yoshiki Kashiwada and Ken-ichi Yamada :
Mechanistic Support for Intramolecular Migrative Cyclization of Propargyl Sulfones Provided by Catalytic Asymmetric Induction with a Chiral Counter Cation Strategy,
Asian Journal of Organic Chemistry, Vol.10, No.7, 1828-1834, 2021.

(徳島大学機関リポジトリ): ● Metadata: 117097
(出版サイトへのリンク): ● Publication site (DOI): 10.1002/ajoc.202100274
(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-85105445485

(徳島大学機関リポジトリ: 117097, DOI: 10.1002/ajoc.202100274, Elsevier: Scopus) Naonobu Tanaka, Sakura Takahashi, Seita Kajihara, Daisuke Tsuji, Kouji Itou, Nilufar Z. Mamadalieva and Yoshiki Kashiwada :
Diterpenes from an Uzbek medicinal plant Perovskia scrophulariifolia: their structures and anti-neuroinflammatory activity,
Fitoterapia, Vol.149, 104826, 2021.

(要約): Phytochemical investigation on the aerial parts of a Lamiaceous medicinal plant Perovskia scrophulariifolia collected in Uzbekistan resulted in the isolation of two new 20-norabietane diterpenes, along with thirteen known diterpenes including one 20-norabietane, eight abietanes, one 6,7-secoabietane, and three icetexanes. The structures of new 20-norabietane diterpenes, perovsfolins C (1) and D (2), were elucidated by spectroscopic analyses aided with calculations of ECD spectra. Perovsfolin C (1) is the first 20-norabietane diterpene possessing a 1,11-epoxy moiety, while perovsfolin D (2) is a 20-norabitetane diterpene with a 2-hydroxy-1,4-quinone moiety as C-ring. Anti-neuroinflammatory activity of the isolated diterpenes on microglial cells was evaluated.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.fitote.2021.104826
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33429024; ● Search Scopus @ Elsevier (PMID): 33429024; ● Search Scopus @ Elsevier (DOI): 10.1016/j.fitote.2021.104826

(DOI: 10.1016/j.fitote.2021.104826, PubMed: 33429024) Naonobu Tanaka, Kanji Niwa, Seita Kajihara, Daisuke Tsuji, Kouji Itou, Nilufar Z. Mamadalieva and Yoshiki Kashiwada :
C28 Terpenoids from Lamiaceous plant Perovskia scrophulariifolia: their structures and anti-neuroinflammatory activity,
Organic Letters, Vol.22, No.19, 7667-7670, 2020.

(要約): Structurally unique C terpenoids, perovsfolins A () and B (), were isolated from the aerial parts of an Uzbek medicinal plant, (Lamiaceae). Their chemical structures including an unprecedented 6/8/6/6/6 pentacyclic carbon skeleton with a C-C ester moiety were elucidated on the basis of spectroscopic analyses aided by density functional theory calculations as well as chemical evidence. Perovsfolin B () exhibited an anti-neuroinflammatory activity.
(出版サイトへのリンク): ● Publication site (DOI): 10.1021/acs.orglett.0c02855
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32941043; ● Search Scopus @ Elsevier (PMID): 32941043; ● Search Scopus @ Elsevier (DOI): 10.1021/acs.orglett.0c02855

(DOI: 10.1021/acs.orglett.0c02855, PubMed: 32941043) Lee Sanghoon, Naonobu Tanaka, TAKAHASHI Sakura, Daisuke Tsuji, KIM Sang-Yong, KOJOMA Mareshige, Kouji Itou, Kobayashi Jun'ichi and Yoshiki Kashiwada :
Agesasines A and B, Bromopyrrole Alkaloids from Marine Sponges Agelas spp.,
Marine Drugs, Vol.18, No.9, 455, 2020.

(要約): Exploration for specialized metabolites of Okinawan marine sponges spp. resulted in the isolation of five new bromopyrrole alkaloids, agesasines A () and B (), 9-hydroxydihydrodispacamide (), 9-hydroxydihydrooroidin (), and 9-keramadine (). Their structures were elucidated on the basis of spectroscopic analyses. Agesasines A () and B () were assigned as rare bromopyrrole alkaloids lacking an aminoimidazole moiety, while - were elucidated to be linear bromopyrrole alkaloids with either aminoimidazolone, aminoimidazole, or -methylated aminoimidazole moieties.
(徳島大学機関リポジトリ): ● Metadata: 116231
(出版サイトへのリンク): ● Publication site (DOI): 10.3390/md18090455
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32872586; ● Search Scopus @ Elsevier (PMID): 32872586; ● Search Scopus @ Elsevier (DOI): 10.3390/md18090455

(徳島大学機関リポジトリ: 116231, DOI: 10.3390/md18090455, PubMed: 32872586) Naonobu Tanaka, Kenta Yamada, Yusei Shimomoto, Daisuke Tsuji, Kouji Itou, Kazuyoshi Kawazoe, Davaadagva Damdinjav, Enkhjargal Dorjval and Yoshiki Kashiwada :
Lophachinins A-E, abietane diterpenes from a Mongolian traditional herbal medicine Lophanthus chinensis,
Fitoterapia, Vol.146, 104702, 2020.

(要約): Five new abietane diterpenes, lophachinins A-E (1-5), and eleven known related diterpenes were isolated from a Mongolian traditional herbal medicine, the aerial parts of Lophanthus chinensis (Lamiaceae). The structures of new diterpenes were assigned by spectroscopic analyses. Lophachinins A (1) and B (2) were abietane diterpene possessing an endoperoxy bridge at C-ring. In contrast, lophachinins C-E (3-5) had an abietane skeleton with an aromatized C-ring. The absolute configuration of 1 was elucidated by application of the modified Mosher's method, while those of 2, 3, and 5 were assigned by chemical conversions. The absolute configuration of lophachinin D (4) was deduced by ECD calculation. Anti-inflammatory activity of isolated diterpenes on microglial cells were evaluated.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.fitote.2020.104702
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32763363; ● Summary page in Scopus @ Elsevier: 2-s2.0-85089268104

(DOI: 10.1016/j.fitote.2020.104702, PubMed: 32763363, Elsevier: Scopus) XueRong Yang, Naonobu Tanaka, Daisuke Tsuji, Feng-Lai Lu, Xiao-Jie Yan, Kouji Itou, Dian-Peng Li and Yoshiki Kashiwada :
Sarcaglabrin A, a conjugate of C15 and C10 terpenes from the aerial parts of Sarcandra glabra,
Tetrahedron Letters, Vol.61, No.25, 151916, 2020.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.tetlet.2020.151916
(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-85085004730

(DOI: 10.1016/j.tetlet.2020.151916, Elsevier: Scopus) Naonobu Tanaka, Niwa Kanji, Yano Yuki and Yoshiki Kashiwada :
Prenylated benzophenone derivatives from Hypericum patulum,
Journal of Natural Medicines, Vol.74, No.1, 264-268, 2020.

(要約): A new prenylated benzophenone, hypatulin C (1), was isolated from the leaves of Hypericum patulum together with a biogenetically related analog, hypelodin B (2). Hypatulin C (1) had a tricyclic [4.3.1.0]-decane moiety substituted by four prenyl groups. The structure of 1 was elucidated by detailed spectroscopic analyses, while the absolute stereochemistries of 1 and 2 were assigned by comparison of their ECD spectra with TDDFT calculated spectra.
(キーワード): Benzophenones / Hypericum / Molecular Structure / Phloroglucinol / Plant Leaves / Prenylation / Stereoisomerism
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s11418-019-01350-3
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31377922; ● Summary page in Scopus @ Elsevier: 2-s2.0-85077666716

(DOI: 10.1007/s11418-019-01350-3, PubMed: 31377922, Elsevier: Scopus) Kanji Niwa, REN YI, Naonobu Tanaka, Shindai Kitaguchi, Daisuke Tsuji, Sang-Yong Kim, Ariuntuya Tsogtbaatar, Perleidulam Bunddulam, Kazuyoshi Kawazoe, Mareshige Kojoma, Davaadagva Damdinjav, Kouji Itou and Yoshiki Kashiwada :
Linaburiosides A-D, acylated iridoid glucosides from Linaria buriatica,
Phytochemistry, Vol.171, 112247, 2020.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.phytochem.2019.112247
(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-85077471922

(DOI: 10.1016/j.phytochem.2019.112247, Elsevier: Scopus) Xuerong Yang, Naonobu Tanaka, Daisuke Tsuji, Lu Feng-Lai, Yan Xiao-Jie, Kouji Itou, Li Dian-Peng and Yoshiki Kashiwada :
Limonoids from the aerial parts of Munronia pinnata,
Tetrahedron, Vol.75, No.52, 130779, 2019.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.tet.2019.130779
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1016/j.tet.2019.130779

(DOI: 10.1016/j.tet.2019.130779) Kanji Niwa, Naonobu Tanaka, Yutaka Tatano, Hideki Yagi and Yoshiki Kashiwada :
Hypascyrins A-E, prenylated acylphloroglucinols from Hypericum ascyron,
Journal of Natural Products, Vol.82, No.10, 2754-2760, 2019.

(要約): Six new prenylated acylphloroglucinols with menthane moieties, hypascyrins A-E (-) and -hyphenrone J (), together with four known analogues, were isolated from roots. Detailed spectroscopic data analyses resulted in the assignment of their structures. The absolute configuration of was deduced by experimental and calculated ECD data, while those of - were assigned by ECD data analyses as well as chemical conversions. Hypascyrins A (), C (), and E () and -hyphenrone J () exhibited antimicrobial activity against MRSA (MIC values of 4.0, 8.0, 2.0, and 4.0 μM, respectively) and (MIC values of 4.0, 4.0, 2.0, and 4.0 μM, respectively).
(出版サイトへのリンク): ● Publication site (DOI): 10.1021/acs.jnatprod.9b00354
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31596079; ● Summary page in Scopus @ Elsevier: 2-s2.0-85073104705

(DOI: 10.1021/acs.jnatprod.9b00354, PubMed: 31596079, Elsevier: Scopus) Tatsuro Yoneyama, Kanako Iseki, Masaaki Noji, Hiroshi Imagawa, Toshihiro Hashimoto, Sachiko Kawano, Masaki Baba, Yoshiki Kashiwada, Tadahiro Yahagi, Keiichi Matsuzaki and Akemi Umeyama :
Marylosides A-G, Norcycloartane Glycosides from Leaves of Great Flower 'Marylaurencin'.,
Molecules, Vol.24, No.13, 2019.

(要約): Seven novel norcycloartane glycosides, maryloside A-G (-), were isolated from the leaves of Great Flower 'Marylaurencin', along with a known norcycloartane glycoside, cymbidoside (). These structures were determined on the basis of mainly NMR experiments as well as chemical degradation and X-ray crystallographic analysis. The isolated compounds (- and ) were evaluated for the inhibitory activity on lipopolysaccharide (LPS) and interferon-γ (IFN-γ)-stimulated nitric oxide (NO) production in RAW 264.7 cells. Consequently, and exhibited moderate activity.
(キーワード): Cell Survival / Flowers / Glycosides / 核磁気共鳴分光法 (nuclear magnetic resonance spectroscopy) / Models, Molecular / 分子構造 (molecular structure) / 一酸化窒素 (nitric oxide) / Orchidaceae / Plant Extracts / Plant Leaves
(徳島大学機関リポジトリ): ● Metadata: 115830
(出版サイトへのリンク): ● Publication site (DOI): 10.3390/molecules24132504
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31323985; ● Search Scopus @ Elsevier (PMID): 31323985; ● Search Scopus @ Elsevier (DOI): 10.3390/molecules24132504

(徳島大学機関リポジトリ: 115830, DOI: 10.3390/molecules24132504, PubMed: 31323985) Kazumi Sagayama, Naonobu Tanaka, Fukumoto Takatoshi and Yoshiki Kashiwada :
Lanostane-type triterpnes from the sclerotium of Inonotus obliquus (Chaga mushrooms) as proproliferative agents on human follicle dermal papilla cells,
Journal of Natural Medicines, Vol.73, No.3, 597-601, 2019.

(要約): Chaga mushrooms, the sclerotium of Inonotus obliquus, have been used in Mongolia as a traditional hair shampoo to maintain healthy hair. Bioassay-guided fractionations of the extract of Chaga mushrooms using a proliferation assay on human follicle dermal papilla cells (HFDPCs) gave five lanostane-type triterpenes (1-5), whose structures were identified by spectroscopic evidence. Among these, lanosterol (1), inotodiol (3), lanost-8,24-diene-3β,21-diol (4), and trametenolic acid (5) demonstrated proproliferative effects on HFDPCs more potent than minoxidil, an anti-alopecia agent, used as the positive control. The lanostane-type triterpenes (1, 3, 4, and 5) appeared to be potential candidates of new agents possibly used for hair-care with a stimulative effect on hair growth.
(キーワード): Agaricales / Androgen Receptor Antagonists / Cell Extracts / Cell Proliferation / Cells, Cultured / Hair / Hair Follicle / Humans / Lanosterol / Mongolia / Receptors, Androgen / Steroids / Triterpenes
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s11418-019-01280-0
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30706371; ● Search Scopus @ Elsevier (PMID): 30706371; ● Search Scopus @ Elsevier (DOI): 10.1007/s11418-019-01280-0

(DOI: 10.1007/s11418-019-01280-0, PubMed: 30706371) Kanji Niwa, Naonobu Tanaka, Sang-Yong Kim, Mareshige Kojoma and Yoshiki Kashiwada :
Hyperdioxane A, a conjugate of dibenzo-1,4-dioxane and sesquiterpene from Hypericum ascyron,
Organic Letters, Vol.20, No.18, 5977-5980, 2018.

(要約): Two new dibenzo-1,4-dioxane derivatives, hyperdioxanes A (1) and B (2), were isolated from the roots of a Hypericaceous plant, Hypericum ascyron. Hyperdioxane A (1) is a conjugate of dibenzo-1,4-dioxane and sesquiterpene with an unprecedented heptacyclic ring system. The structures of 1 and 2 were assigned by detailed spectroscopic analyses, including application of a modified Mosher's method. A possible biogenetic pathway of hyperdioxane A (1) from hyperdioxane B (2) and a sesquiterpene, eremophil-9,11(13)-dien-8β,12-olide (3), is presented.
(出版サイトへのリンク): ● Publication site (DOI): 10.1021/acs.orglett.8b02739
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30207481; ● Summary page in Scopus @ Elsevier: 2-s2.0-85053670616

(DOI: 10.1021/acs.orglett.8b02739, PubMed: 30207481, Elsevier: Scopus) Suyama Yoshihiro, Naonobu Tanaka, Kazuyoshi Kawazoe, Kotarou Murakami, Li Shun-Lin, Sun Han-Dong and Yoshiki Kashiwada :
Rigenolides D-H, norsecoiridoid and secoiridoids from Gentiana rigescens Franch,
Journal of Natural Medicines, Vol.72, No.2, 576-581, 2018.

(要約): Five new compounds, rigenolides D-H (1-5), were isolated from the aerial parts of Gentiana rigescens Franch. Their structures were assigned by detailed spectroscopic analyses and chemical conversions. Rigenolides D (1) and E (2) were elucidated to be a secoiridoid and a norsecoiridoid, respectively, possessing a dienone moiety in common. Rigenolides F-H (3-5) were assigned as acylated secoiridoid glucosides.
(キーワード): Gentiana / Iridoids / Molecular Structure / Plant Extracts
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s11418-018-1181-2
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29423590; ● CiNii @ 国立情報学研究所 (CRID): 1520291855102268160; ● Search Scopus @ Elsevier (PMID): 29423590; ● Search Scopus @ Elsevier (DOI): 10.1007/s11418-018-1181-2

(DOI: 10.1007/s11418-018-1181-2, PubMed: 29423590, CiNii: 1520291855102268160) Lee Sanghoon, Naonobu Tanaka, Kobayashi Jun'ichi and Yoshiki Kashiwada :
Agelamasines A and B, diterpene alkaloids from an Okinawan marine sponge Agelas sp.,
Journal of Natural Medicines, Vol.72, No.1, 364-368, 2018.

(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s11418-017-1157-7
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29198066; ● Summary page in Scopus @ Elsevier: 2-s2.0-85035769505

(DOI: 10.1007/s11418-017-1157-7, PubMed: 29198066, Elsevier: Scopus) Naonobu Tanaka, Jia Yuyu, Niwa Kanji, Imabayashi Kiyoshi, Tatano Yutaka, Yagi Hideki and Yoshiki Kashiwada :
Phloroglucinol derivatives and a chromone gluycoside from the leaves of Myrtus communis,
Tetrahedron, Vol.74, No.1, 117-123, 2018.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.tet.2017.11.044
(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-85034817871

(DOI: 10.1016/j.tet.2017.11.044, Elsevier: Scopus) Wenting Xu, Licht Miyamoto, Haruna Aihara, Tomomi Yamaoka, Naonobu Tanaka, Yuki Tsuchihashi, Yasumasa Ikeda, Toshiaki Tamaki, Yoshiki Kashiwada and Koichiro Tsuchiya :
Methanol extraction fraction from Citrus Sudachi peel exerts lipid reducing effects in cultured cells.,
The Journal of Medical Investigation : JMI, Vol.65, No.3.4, 225-230, 2018.

(要約): Ectopic fat accumulation is associated with insulin resistance and type 2 diabetes mellitus. Citrus sudachi is an evergreen tree that is found mainly in Tokushima Prefecture in Japan. Previously, it was demonstrated that Citrus sudachi could inhibit the rising trend of blood glucose and fatty acid in human subjects. In the current study, we illustrated the function of methanol extracts from sudachi peel and investigated the mechanism of this effect. We got the five kinds of methanol extracts by using diaion HP-20, and those were named by hydrophobicity from M-F1 to M-F5. Among the 5 kinds of sudachi methanol extracts, only M-F4 significantly decreased the intracellular triglyceride of C2C12 cells. It augmented the AMPK activity and increased the transcription of PPARα and its downstream targets CPT-1b and UCP2. In conclusion, M-F4 improved the lipid metabolism possibly through AMPK, PPARα and their downstream targets like CPT-1b and UCP2. Furthermore, this extract may be useful for preventing obesity and diabetes related diseases. J. Med. Invest. 65:225-230, August, 2018.
(キーワード): AMP-Activated Protein Kinases / Animals / Cell Line / Citrus / Humans / Hypolipidemic Agents / Lipid Metabolism / メタノール (methanol) / ノックアウトマウス (knockout mice) / Models, Biological / PPAR alpha / Phytotherapy / Plant Extracts / シグナル伝達 (signal transduction) / Sirtuin 1 / Triglycerides
(徳島大学機関リポジトリ): ● Metadata: 112243
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.65.225
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30282865; ● Search Scopus @ Elsevier (PMID): 30282865; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.65.225

(徳島大学機関リポジトリ: 112243, DOI: 10.2152/jmi.65.225, PubMed: 30282865) Suyama Yoshihiro, Higashino Yusuke, Naonobu Tanaka, Tatano Yutaka, Yagi Hideki, Kazuyoshi Kawazoe, Kotarou Murakami, Li Shun-Lin, Sun Han-Dong and Yoshiki Kashiwada :
Stereochemical assignments of rubiaquinones A-C, naphthoquinone derivatives from Rubia yunnanensis,
Tetrahedron Letters, Vol.58, No.48, 4568-4571, 2017.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.tetlet.2017.10.051
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1016/j.tetlet.2017.10.051

(DOI: 10.1016/j.tetlet.2017.10.051) Sekita Yasuko, Keiji Murakami, Hiromichi Yumoto, Kouji Hirao, Takashi Amoh, Natsumi Fujiwara, Katsuhiko Hirota, Hideki Fujii, Takashi Matsuo, Yoichiro Miyake and Yoshiki Kashiwada :
Antibiofilm and Anti-Inflammatory Activities of+ Houttuynia cordata Decoction for Oral Care,
Evidence-Based Complementary and Alternative Medicine : eCAM, Vol.2017, 2850947, 2017.

(要約): Dental biofilms that form in the oral cavity play a critical role in the pathogenesis of several infectious oral diseases, including dental caries, periodontal disease, and oral candidiasis. (HC, Saururaceae) is a widely used traditional medicine, for both internal and external application. A decoction of dried HC leaves (dHC) has long been consumed as a health-promoting herbal tea in Japan. We have recently reported that a water solution of HC poultice ethanol extract (wHCP) exerts antimicrobial and antibiofilm effects against several important oral pathogens. It also exhibits anti-inflammatory effects on human keratinocytes. In our current study, we examined the effects of dHC on infectious oral pathogens and inflammation. Our results demonstrated that dHC exerts moderate antimicrobial effects against methicillin-resistant (MRSA) and other oral microorganisms. dHC also exhibited antibiofilm effects against MRSA, (involved in dental plaque formation), and and inhibitory effects on interleukin-8, CCL20, IP-10, and GRO productions by human oral keratinocytes stimulated by lipopolysaccharide (a cause of periodontal disease), without cytotoxic effects. This suggests that dHC exhibits multiple activities in microorganisms and host cells. dHC can be easily prepared and may be effective in preventing infectious oral diseases.
(徳島大学機関リポジトリ): ● Metadata: 112956
(出版サイトへのリンク): ● Publication site (DOI): 10.1155/2017/2850947
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29234378; ● Summary page in Scopus @ Elsevier: 2-s2.0-85042323475

(徳島大学機関リポジトリ: 112956, DOI: 10.1155/2017/2850947, PubMed: 29234378, Elsevier: Scopus) Suyama Yoshihiro, Naonobu Tanaka, Kazuyoshi Kawazoe, Kotarou Murakami, Shun-Lin Li, Han-Dong Sun and Yoshiki Kashiwada :
Rigenolides B and C, conjugates of norsecoiridoid and secoiridoid glucoside from Gentiana rigescens Franch.,
Tetrahedron Letters, Vol.58, No.15, 1459-1461, 2017.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.tetlet.2017.02.075
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1016/j.tetlet.2017.02.075

(DOI: 10.1016/j.tetlet.2017.02.075) Kanji Niwa, Naonobu Tanaka and Yoshiki Kashiwada :
Frondhyperins A-D, short ketide-phenylketide conjugates from Hypericum frondosum cv. Sunburst,
Tetrahedron Letters, Vol.58, No.15, 1495-1498, 2017.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.tetlet.2017.02.089
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1016/j.tetlet.2017.02.089

(DOI: 10.1016/j.tetlet.2017.02.089) Kim Sang-Yong, Nagashima Hisako, Naonobu Tanaka, Yoshiki Kashiwada, Kobayashi Jun'ichi and Kojoma Mareshige :
Hitorins A and B, hexacyclic C25 terpenoids from Chloranthus japonicus,
Organic Letters, Vol.18, 5420-5423, 2016.

(要約): Two novel C25 terpenoids with a 6/5/5/5/5/3 hexacyclic skeleton including one γ-lactone ring and two tetrahydrofuran rings, hitorins A (1) and B (2), were isolated from the aerial parts of Chloranthus japonicus. The structures of 1 and 2 were elucidated on the basis of spectroscopic analyses as well as TDDFT ECD calculations. Hitorins A (1) and B (2) might be biogenetically derived from eudesmane sesquiterpene and thujane monoterpene.
(出版サイトへのリンク): ● Publication site (DOI): 10.1021/acs.orglett.6b02842
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27718583; ● Summary page in Scopus @ Elsevier: 2-s2.0-84992616467

(DOI: 10.1021/acs.orglett.6b02842, PubMed: 27718583, Elsevier: Scopus) Naonobu Tanaka, Yuki Yano, Yutaka Tatano and Yoshiki Kashiwada :
Hypatulins A and B, meroterpenes from Hypericum patulum,
Organic Letters, Vol.18, No.20, 5360-5363, 2016.

(要約): Two novel prenylated benzophenone related meroterpenes, hypatulins A (1) and B (2), were isolated from the leaves of Hypericum patulum. The structures of 1 and 2 were assigned by spectroscopic analysis, chemical conversion, and calculations of the ECD (electron circular dichroism) spectra. Hypatulin A (1) had a unique densely substituted tricyclic octahydro-1,5-methanopentalene core, while hypatulin B (2) possessed a bicyclo[3.2.1]octane moiety. Hypatulin A (1) exhibited antimicrobacterial activity against Bacillus subtilis. A possible biogenetic pathway of the new meroterpenes 1 and 2 from a prenylated benzophenone was presented.
(出版サイトへのリンク): ● Publication site (DOI): 10.1021/acs.orglett.6b02725
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27682178; ● Search Scopus @ Elsevier (PMID): 27682178; ● Search Scopus @ Elsevier (DOI): 10.1021/acs.orglett.6b02725

(DOI: 10.1021/acs.orglett.6b02725, PubMed: 27682178) Kentaro Igami, Yosuke Shimojo, Hisatomi Ito, Toshitsugu Miyazaki, Fusako Nakano and Yoshiki Kashiwada :
Fermented Ginseng Contains an Agonist of Peroxisome Proliferator Activated Receptors and .,
Journal of Medicinal Food, Vol.19, No.9, 817-822, 2016.

(要約): Peroxisome proliferator activated receptor (PPAR) is a nuclear receptor that is one of the transcription factors regulating lipid and glucose metabolism. Fermented ginseng (FG) is a ginseng fermented by Lactobacillus paracasei A221 containing minor ginsenosides and metabolites of fermentation. DNA microarray analysis of rat liver treated with FG indicated that FG affects on lipid metabolism are mediated by PPAR-. To identify a PPAR- agonist in FG, PPAR- transcription reporter assay-guided fractionation was performed. The fraction obtained from the MeOH extract of FG, which showed potent transcription activity of PPAR-, was fractionated by silica gel column chromatography into 16 subfractions, and further separation and crystallization gave compound 1 together with four known constituents of ginseng, including 20(R)- and 20(S)-protopanaxadiol, and 20(R)- and 20(S)-ginsenoside Rh1. The structure of compound 1 was identified as 10-hydroxy-octadecanoic acid by (1)H- and (13)C-NMR spectra and by EI-MS analysis of the methyl ester of 1. Compound 1 demonstrated much higher transcription activity of PPAR- than the other isolated compounds. In addition, compound 1 also showed 5.5-fold higher transcription activity of PPAR- than vehicle at the dose of 20 g/mL. In the present study, we identified 10-hydroxy-octadecanoic acid as a dual PPAR-/ agonist in FG. Our study suggested that metabolites of fermentation, in addition to ginsenosides, contribute to the health benefits of FG.
(出版サイトへのリンク): ● Publication site (DOI): 10.1089/jmf.2016.3673
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27627700; ● Search Scopus @ Elsevier (PMID): 27627700; ● Search Scopus @ Elsevier (DOI): 10.1089/jmf.2016.3673

(DOI: 10.1089/jmf.2016.3673, PubMed: 27627700) Lu Shuangxin, Naonobu Tanaka, Tatano Yutaka and Yoshiki Kashiwada :
Erecricins A-E, prenylated acylphloroglucinols from the roots of Hypericum erectum,
Fitoterapia, Vol.114, 188-193, 2016.

(要約): Six new prenylated acylphloroglucinols, erecricins A-E (1-5) and adotogirin (6), were isolated from the roots of Hypericum erectum (Hypericaceae). Their structures were assigned on the basis of spectroscopic evidences. Erecricins A-E (1-5) are bicyclic prenylated acylphloroglucinols possessing a chromane or a chromene skeleton. Adotogirin (6) is a simple achylphloroglucinol with an O-geranyl moiety. Antimicrobial activities of these acylphloroglucinols were also evaluated.
(キーワード): Anti-Bacterial Agents / Bacteria / Hypericum / Microbial Sensitivity Tests / Molecular Structure / Phloroglucinol / Plant Roots / Prenylation
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.fitote.2016.08.014
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27575327; ● Search Scopus @ Elsevier (PMID): 27575327; ● Search Scopus @ Elsevier (DOI): 10.1016/j.fitote.2016.08.014

(DOI: 10.1016/j.fitote.2016.08.014, PubMed: 27575327) Kurimoto Shin-ichiro, Sasaki F. Yu, Yoshihiro Suyama, Naonobu Tanaka, Yoshiki Kashiwada and Nakamura Takanori :
Acylated triterpene saponins from the stem bark of Acer nikoense,
Chemical & Pharmaceutical Bulletin, Vol.64, No.7, 924-929, 2016.

(要約): Three new acylated triterpene saponins, acernikoenosides A-C (1-3), were isolated from the stem bark of Acer nikoense, together with a known sterol glucoside. Their structures were elucidated on the basis of extensive spectroscopic analyses. This study provided the first example of triterpene saponins isolated from this plant. The anti-genotoxic activity of 1, 3 and 4 against ultraviolet irradiation was evaluated by comet assay.
(出版サイトへのリンク): ● Publication site (DOI): 10.1248/cpb.c16-00146
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27373647; ● Summary page in Scopus @ Elsevier: 2-s2.0-84977547361

(DOI: 10.1248/cpb.c16-00146, PubMed: 27373647, Elsevier: Scopus) Naonobu Tanaka, Tsuji Eri, Yoshiki Kashiwada and Kobayashi Jun'ichi :
Yezo'otogirins A-H, acylphloroglucinols and meroterpenes from Hypericum yezoense,
Chemical & Pharmaceutical Bulletin, Vol.64, No.7, 991-995, 2016.

(要約): Investigation of the methanolic extract from the aerial parts of Hypericum yezoense resulted in the isolation of three new acylphloroglucinols, yezo'otogirins D-F (1-3), and two new meroterpenes, yezo'otogirins G (4) and H (5). The structures of 1-5 were assigned on the basis of spectroscopic data. Yezo'otogirin D (1) is an acylphloroglucinol with a monoterpene moiety linked through an ether bond, while yezo'otogirins E (2) and F (3) are polyprenylated acylphloroglucinols possessing a tricyclic core. Yezo'otogirins G (4) and H (5) are linear meroterpenes with an enolized -diketone moiety. Yezo'otogirin E (2) exhibited antimicrobial activity against Escherichia coli and Staphylococcus aureus.
(出版サイトへのリンク): ● Publication site (DOI): 10.1248/cpb.c16-00243
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27373661; ● Search Scopus @ Elsevier (PMID): 27373661; ● Search Scopus @ Elsevier (DOI): 10.1248/cpb.c16-00243

(DOI: 10.1248/cpb.c16-00243, PubMed: 27373661) Yasuko Sekita, Keiji Murakami, Hiromichi Yumoto, Takashi Amoh, Natsumi Fujiwara, Shohei Ogata, Takashi Matsuo, Yoichiro Miyake and Yoshiki Kashiwada :
Preventive Effects of Houttuynia cordata Extract for Oral Infectious Diseases.,
BioMed Research International, Vol.2016, 2581876, 2016.

(要約): Houttuynia cordata (HC) (Saururaceae) has been used internally and externally as a traditional medicine and as an herbal tea for healthcare in Japan. Our recent survey showed that HC poultice (HCP) prepared from smothering fresh leaves of HC had been frequently used for the treatment of purulent skin diseases with high effectiveness. Our experimental study also demonstrated that ethanol extract of HCP (eHCP) has antibacterial, antibiofilm, and anti-inflammatory effects against S. aureus which caused purulent skin diseases. In this study, we focused on novel effects of HCP against oral infectious diseases, such as periodontal disease and dental caries. We determined the antimicrobial and antibiofilm effects of water solution of HCP ethanol extract (wHCP) against important oral pathogens and investigated its cytotoxicity and anti-inflammatory effects on human oral epithelial cells. wHCP had moderate antimicrobial effects against some oral microorganisms and profound antibiofilm effects against Fusobacterium nucleatum, Streptococcus mutans, and Candida albicans. In addition, wHCP had no cytotoxic effects and could inhibit interleukin-8 and CCL20 productions by Porphyromonas gingivalis lipopolysaccharide-stimulated human oral keratinocytes. Our findings suggested that wHCP may be clinically useful for preventing oral infectious diseases as a mouthwash for oral care.
(キーワード): Anti-Bacterial Agents / 細菌 (bacteria) / Biofilms / Cell Line / Cell Survival / Dental Caries / Houttuynia / Humans / Periodontal Diseases / Plant Extracts
(徳島大学機関リポジトリ): ● Metadata: 112384
(出版サイトへのリンク): ● Publication site (DOI): 10.1155/2016/2581876
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27413739; ● Summary page in Scopus @ Elsevier: 2-s2.0-84978765486

(徳島大学機関リポジトリ: 112384, DOI: 10.1155/2016/2581876, PubMed: 27413739, Elsevier: Scopus) Naonobu Tanaka, Niwa Kanji and Yoshiki Kashiwada :
Merohyperins A-C, meroterpenes from the leaves of Hypericum chinense,
Tetrahedron Letters, Vol.57, No.29, 3175-3178, 2016.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.tetlet.2016.06.028
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1016/j.tetlet.2016.06.028

(DOI: 10.1016/j.tetlet.2016.06.028) Lu Shuangxin, Naonobu Tanaka, Kazuyoshi Kawazoe, Kotarou Murakami, Damdinjav Davaadagva, Dorjbal Enkhjargal and Yoshiki Kashiwada :
Tetrahydroxanthones from Mongolian medicinal plant Gentianella amarella ssp. acuta,
Journal of Natural Medicines, Vol.70, No.4, 780-788, 2016.

(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s11418-016-1015-z
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27306440; ● Summary page in Scopus @ Elsevier: 2-s2.0-84974823949

(DOI: 10.1007/s11418-016-1015-z, PubMed: 27306440, Elsevier: Scopus) Yasuko Sekita, Keiji Murakami, Hiromichi Yumoto, Hiroyuki Mizuguchi, Takashi Amoh, Satoshi Ogino, Takashi Matsuo, Yoichiro Miyake, Hiroyuki Fukui and Yoshiki Kashiwada :
Anti-bacterial and anti-inflammatory effects of ethanol extract from Houttuynia cordata poultice.,
Bioscience, Biotechnology, and Biochemistry, 2016.

(要約): Houttuynia cordata (HC) has been commonly used as many traditional remedies in local areas of Japan. Although many pharmacological activities of HC have been reported, the mechanism underlying the effect of HC remains unknown. We conducted the interview survey in Japan to verify how HC was actually used. The interview survey revealed that HC poultice (HCP) prepared from smothering fresh leaves of HC was most frequently used for the treatment of purulent skin diseases including furuncle and carbuncle with high effectiveness. Ethanol extract of HCP (eHCP) showed anti-bacterial effects against methicillin-resistant Staphylococcus aureus (MRSA), and showed an anti-biofilm activity against MRSA. eHCP showed dose-dependent inhibition of S. aureus lipoteichoic acid (LTA)-induced interleukin-8 and CCL20 production in human keratinocyte without any cytotoxicity. These results suggest that HCP is effective for skin abscess and its underlying mechanism might be the complicated multiple activities for both bacteria and host cells.
(出版サイトへのリンク): ● Publication site (DOI): 10.1080/09168451.2016.1151339
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27023331; ● Search Scopus @ Elsevier (PMID): 27023331; ● Search Scopus @ Elsevier (DOI): 10.1080/09168451.2016.1151339

(DOI: 10.1080/09168451.2016.1151339, PubMed: 27023331) Shin-Ichiro Kurimoto, Jian-Xin Pu, Han-Dong Sun, Hirofumi Shibata, Yoshihisa Takaishi and Yoshiki Kashiwada :
Acylated neo-clerodane type diterpenoids from the aerial parts of Scutellaria coleifolia Levl. (Lamiaceae).,
Journal of Natural Medicines, 2016.

(要約): Twenty new neo-clerodane type diterpenoids, scutefolides G1-S (1-20), were isolated from the 70 % aqueous acetone extract of the aerial parts of Scutellaria coleifolia. Their structures were elucidated by extensive spectroscopic analyses. The absolute configurations of 1, 2, 7, 8, 14 and 15 were determined by means of the CD exciton chirality method. Compounds 1, 2, 5, 7, 8, 12, 14, 15, 18 and 19 were evaluated for their cytotoxic activities against four human cancer cell lines, and anti-bacterial activities against methicillin-resistant Staphylococcus aureus.
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s11418-016-0967-3
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26825781; ● Search Scopus @ Elsevier (PMID): 26825781; ● Search Scopus @ Elsevier (DOI): 10.1007/s11418-016-0967-3

(DOI: 10.1007/s11418-016-0967-3, PubMed: 26825781) Manik Chandra Shill, Hiroyuki Mizuguchi, Sanmoy Karmakar, Takuya Kadota, Pulok K. Mukherjee, Yoshiki Kashiwada, Yoshiaki Kitamura, Hisao Nemoto, Noriaki Takeda and Hiroyuki Fukui :
A novel benzofuran, 4-methoxybenzofuran-5-carboxamide, from Tephrosia purpurea suppressed histamine H1 receptor gene expression through a protein kinase C--dependent signaling pathway.,
International Immunopharmacology, Vol.30, 18-26, 2016.

(要約): Histamine H1 receptor (H1R) gene is upregulated in patients with allergic rhinitis (AR), and its expression level is strongly correlated with the severity of allergic symptoms. We previously reported isolation of the putative anti-allergic compound, 4-methoxybenzofuran-5-carboxamide (MBCA) from Tephrosia purpurea and its chemical synthesis (Shill et al., Bioorg Med Chem 2015;23:6869-6874). However, the mechanism underlying its anti-allergic activity remains to be elucidated. Here, we report the mechanism of MBCA on phorbol 12-myristate-13-acetate (PMA)- or histamine-induced upregulation of H1R gene expression in HeLa cells, and in vivo effects of MBCA were also determined in toluene-2,4-diisocyanate (TDI)-sensitized rats. MBCA suppressed PMA- and histamine-induced upregulation of H1R expression at both mRNA and protein levels and inhibited PMA-induced phosphorylation of PKCδ at Tyr(311) and subsequent translocation to the Golgi. Furthermore, MBCA ameliorated allergic symptoms and suppressed the elevation of H1R and helper T cell type 2 (Th2) cytokine mRNAs in TDI-sensitized rats. Data suggest that MBCA alleviates nasal symptoms in TDI-sensitized rats through the inhibition of H1R and Th2 cytokine gene expression. The mechanism of its H1R gene suppression underlies the inhibition of PKCδ activation.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.intimp.2015.11.021
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26619301; ● Summary page in Scopus @ Elsevier: 2-s2.0-84948402928

(DOI: 10.1016/j.intimp.2015.11.021, PubMed: 26619301, Elsevier: Scopus) Nakajima Hiroyuki, Kazuchika Nishitsuji, Kawashima Hiroyuki, Kuwabara Kaori, Mikawa Shiho, Uchimura Kenji, Akaji Kenichi, Yoshiki Kashiwada, Kobayashi Norihiro, Hiroyuki Saito and Naomi Sakashita :
The polyphenol (-)-epigallocatechin-3-gallate prevents apoA-IIowa amyloidosis in vitro and protects human embryonic kidney 293 cells against amyloid cytotoxicity,
Amyloid, Vol.23, No.1, 17-25, 2015.

(要約): Apolipoprotein A-I (apoA-I) amyloidosis is either a non-hereditary form with deposits of wild-type apoA-I proteins in atherosclerotic plaques or a hereditary form with progressive accumulation of mutant apoA-I proteins in different tissues. Several small polyphenolic molecules reportedly inhibited formation of fibrillar assemblies of some amyloidogenic proteins and their cytotoxicity, but small molecules that inhibit apoA-I fibril formation have never been reported. Our methods included a thioflavin-T-binding assay, atomic force microscopy and dot blot and cell-based assays. We showed that (-)-epigallocatechin-3-gallate (EGCG), a tea-derived flavanol, inhibited in vitro fibril formation and disaggregated fibrils preformed by the N-terminal 1-83 fragments of wild-type (WT) apoA-I and the G26R point mutation of apoA-I (apoA-IIowa). We eliminated a common structure recognized by the anti-amyloid antibody OC by incubating apoA-IIowa with EGCG or treating apoA-IIowa fibrils with EGCG, which supported the above observation. In addition, EGCG rescued human embryonic kidney 293 cells from cytotoxicity and attenuated production of reactive oxygen species, which were induced by apoA-IIowa fibrils. Our results support the concept that EGCG inhibits amyloid fibril formation of various amyloidogenic proteins. Thus, EGCG may be a candidate for providing a structure to develop de novo inhibitors for amyloidosis treatment.
(出版サイトへのリンク): ● Publication site (DOI): 10.3109/13506129.2015.1113167
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26701221; ● Summary page in Scopus @ Elsevier: 2-s2.0-84959249052

(DOI: 10.3109/13506129.2015.1113167, PubMed: 26701221, Elsevier: Scopus) C M Shill, AK Das, T Itou, S Karmakar, PK Mukherjee, Hiroyuki Mizuguchi, Yoshiki Kashiwada, Hiroyuki Fukui and Hisao Nemoto :
The isolation and synthesis of a novel benzofuran compound from Tephrosia purpurea, and the synthesis of several related derivatives, which suppress histamine H1 receptor gene expression.,
Bioorganic & Medicinal Chemistry, Vol.23, No.21, 6869-6874, 2015.

(要約): A novel naturally occurring compound with a benzofuran skeleton was isolated from a plant, Tephrosia purpurea collected in Bangladesh. The chemical synthesis of this compound confirmed its structure, and preliminary biological results showed its suppressive activity towards histamine H1 gene expression. One isomer and four derivatives were also synthesized, and their suppression activity was investigated. Although only small quantities of this compound can be isolated from its natural source, a 10 g scale synthesis was demonstrated by the newly developed method.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.bmc.2015.09.049
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26476665; ● Search Scopus @ Elsevier (PMID): 26476665; ● Search Scopus @ Elsevier (DOI): 10.1016/j.bmc.2015.09.049

(DOI: 10.1016/j.bmc.2015.09.049, PubMed: 26476665) Hiroyuki Mizuguchi, Y Nariai, S Kato, T Nakano, T Kanayama, Yoshiki Kashiwada, Hisao Nemoto, Kazuyoshi Kawazoe, Yoshihisa Takaishi, Yoshiaki Kitamura, Noriaki Takeda and Hiroyuki Fukui :
Maackiain is a novel antiallergic compound that suppresses transcriptional upregulation of the histamine H1 receptor and interleukin-4 genes.,
Pharmacology Research & Perspectives, Vol.3, No.5, e00166, 2015.

(要約): Kujin contains antiallergic compounds that inhibit upregulation of histamine H1 receptor (H1R) and interleukin (IL)-4 gene expression. However, the underlying mechanism remains unknown. We sought to identify a Kujin-derived antiallergic compound and investigate its mechanism of action. The H1R and IL-4 mRNA levels were determined by real-time quantitative RT-PCR. To investigate the effects of maackiain in vivo, toluene-2,4-diisocyanate (TDI)-sensitized rats were used as a nasal hypersensitivity animal model. We identified (-)-maackiain as the responsible component. Synthetic maackiain showed stereoselectivity for the suppression of IL-4 gene expression but not for H1R gene expression, suggesting distinct target proteins for transcriptional signaling. (-)-Maackiain inhibited of PKCδ translocation to the Golgi and phosphorylation of Tyr(311) on PKCδ, which led to the suppression of H1R gene transcription. However, (-)-maackiain did not show any antioxidant activity or inhibition of PKCδ enzymatic activity per se. Pretreatment with maackiain alleviated nasal symptoms and suppressed TDI-induced upregulations of H1R and IL-4 gene expressions in TDI-sensitized rats. These data suggest that (-)-maackiain is a novel antiallergic compound that alleviates nasal symptoms in TDI-sensitized allergy model rats through the inhibition of H1R and IL-4 gene expression. The molecular mechanism underlying its suppressive effect for H1R gene expression is mediated by the inhibition of PKCδ activation.
(徳島大学機関リポジトリ): ● Metadata: 115685
(出版サイトへのリンク): ● Publication site (DOI): 10.1002/prp2.166
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26516579; ● Search Scopus @ Elsevier (PMID): 26516579; ● Search Scopus @ Elsevier (DOI): 10.1002/prp2.166

(徳島大学機関リポジトリ: 115685, DOI: 10.1002/prp2.166, PubMed: 26516579) Shin-Ichiro Kurimoto, Jian-Xin Pu, Han-Dong Sun, Yoshihisa Takaishi and Yoshiki Kashiwada :
Coleifolides A and B, Two New Sesterterpenoids from the Aerial Parts of Scutellaria coleifolia H.Lév.,
Chemistry & Biodiversity, Vol.12, No.8, 1200-1207, 2015.

(要約): Coleifolides A and B (1 and 2), two new sesterterpenoids with a -methyl-,-unsaturated--lactone moiety, were isolated from the aerial parts of Scutellaria coleifolia H.Lév. (Lamiaceae), together with three known compounds. Their structures were elucidated by NMR and MS examinations. Coleifolides A and B were concluded to be partially racemic compounds by the HPLC analysis using a chiral column or introduction of chiral derivatizing agents. The absolute configuration of the major isomer was determined by analyses of the CD spectrum as well as NMR data of (R)- and (S)-2-NMA derivatives. Coleifolides A and B are structurally similar to manoalide derivatives, previously isolated from marine sponges, and appear to be the first examples of this type of compounds being isolated from higher plants.
(出版サイトへのリンク): ● Publication site (DOI): 10.1002/cbdv.201400248
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26265571; ● Summary page in Scopus @ Elsevier: 2-s2.0-84934886601

(DOI: 10.1002/cbdv.201400248, PubMed: 26265571, Elsevier: Scopus) Kusama Taishi, Naonobu Tanaka, Yoshiki Kashiwada and Jun'ichi Kobayashi :
Agelamadin F and tauroacidin E, bromopyrrole alkaloids from an Okinawan marine sponge Agelas sp.,
Tetrahedron Letters, Vol.56, No.30, 4502-4504, 2015.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.tetlet.2015.05.114
(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-84933182304

(DOI: 10.1016/j.tetlet.2015.05.114, Elsevier: Scopus) Tsung-I Hsu, Ying-Jung Chen, Chia-Yang Hung, Yi-Chang Wang, Sin-Jin Lin, Wu-Chou Su, Ming-Derg Lai, Sang-Yong Kim, Qiang Wang, Keduo Qian, Masuo Goto, Yu Zhao, Yoshiki Kashiwada, Kuo-Hsiung Lee, Wen-Chang Chang and Jan-Jong Hung :
A novel derivative of betulinic acid, SYK023, suppresses lung cancer growth and malignancy.,
Oncotarget, Vol.6, No.15, 13671-13687, 2015.

(要約): Herein, we evaluated the anti-cancer effect and molecular mechanisms of a novel betulinic acid (BA) derivative, SYK023, by using two mouse models of lung cancer driven by KrasG12D or EGFRL858R. We found that SYK023 inhibits lung tumor proliferation, without side effects in vivo or cytotoxicity in primary lung cells in vitro. SYK023 triggered endoplasmic reticulum (ER) stress. Blockage of ER stress in SYK023-treated cells inhibited SYK023-induced apoptosis. In addition, we found that the expression of cell cycle-related genes, including cyclin A2, B1, D3, CDC25a, and CDC25b decreased but, while those of p15INK4b, p16INK4a, and p21CIP1 increased following SYK023 treatment. Finally, low doses of SYK023 significantly decreased lung cancer metastasis in vitro and in vivo. Expression of several genes related to cell migration, including synaptopodin, were downregulated by SYK023, thereby impairing F-actin polymerization and metastasis. Therefore, SYK023 may be a potentially therapeutic treatment for metastatic lung cancer.
(キーワード): Animals / Antineoplastic Agents / Cell Line, Tumor / Cell Movement / Cell Proliferation / Disease Models, Animal / Humans / Lung Neoplasms / Male / Mice / Mice, Inbred BALB C / Mice, SCID / Mice, Transgenic / Neoplasm Metastasis / Prognosis / Transfection / Triterpenes / Xenograft Model Antitumor Assays
(出版サイトへのリンク): ● Publication site (DOI): 10.18632/oncotarget.3701
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25909174; ● Summary page in Scopus @ Elsevier: 2-s2.0-84931097744

(DOI: 10.18632/oncotarget.3701, PubMed: 25909174, Elsevier: Scopus) Shin-ichiro Kurimoto, Jian-Xin Pu, Han-Dong Sun, Yoshihisa Takaishi and Yoshiki Kashiwada :
Acylated neo-clerodanes and 19-nor-neo-clerodanes from the aerial parts of Scutellaria coleifolia (Lamiaceae).,
Phytochemistry, Vol.116, 298-304, 2015.

(要約): Scutefolides A1 and A2, two acylated neo-clerodanes with a 19,18--lactone, scutefolides B1, B2 and C, three 19-nor-neo-clerodanes, together with scutefolides D, E1, E2 and F, four neo-clerodanes, were isolated from the EtOAc-soluble fraction of the aerial parts of Scutellaria coleifolia. Their structures were established on the basis of spectroscopic analysis. The absolute configurations of four of these compounds were elucidated by the CD exciton chirality method. Cytotoxic activities of scutefolides D-F against four cancer cell lines (KB, A549, HeLa, and MCF7) were also evaluated, but they were inactive.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.phytochem.2015.05.012
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26026223; ● Search Scopus @ Elsevier (PMID): 26026223; ● Search Scopus @ Elsevier (DOI): 10.1016/j.phytochem.2015.05.012

(DOI: 10.1016/j.phytochem.2015.05.012, PubMed: 26026223) Kentaro Igami, Yosuke Shimojo, Hisatomi Ito, Toshitsugu Miyazaki and Yoshiki Kashiwada :
Hepatoprotective effect of fermented ginseng and its major constituent compound K in a rat model of paracetamol (acetaminophen)-induced liver injury.,
The Journal of Pharmacy and Pharmacology, Vol.67, No.4, 565-572, 2015.

(要約): FG was shown to possess hepatoprotective activity against paracetamol (APAP)-induced liver injury better than FRG. Compound K might play an important role for an anti-inflammatory activity of FG by inhibiting JNK signalling in the liver.
(出版サイトへのリンク): ● Publication site (DOI): 10.1111/jphp.12342
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25495794; ● Summary page in Scopus @ Elsevier: 2-s2.0-84925802950

(DOI: 10.1111/jphp.12342, PubMed: 25495794, Elsevier: Scopus) Ai Hirata, Sang-Yong Kim, Natsuki Kobayakawa, Naonobu Tanaka and Yoshiki Kashiwada :
Miltiorins A-D, diterpenes from Radix Salviae miltiorrhizae,
Fitoterapia, Vol.102, No.C, 49-55, 2015.

(要約): Constituents of the anti-influenza A neuraminidase (NA) active extract from Radix Salviae miltiorrhizae were investigated, resulting in the isolation of four new diterpenes, miltiorins A-D (1-4), together with eight known diterpenes. The structures of 1-4 were assigned by spectroscopic analysis. Miltiorins A-C (1-3) were abietane diterpenes possessing a 2-acetoxy group and a 12-hydroxy group in common, while miltiorin D (4) was a 11,12-seco-abietane diterpene with a -lactone ring. Miltiorin D (4) is the first example of a 11,12-seco-abietane diterpene from natural sources. Anti-NA activities of the isolated diterpenes were evaluated.
(キーワード): Antiviral Agents / Diterpenes, Abietane / 分子構造 (molecular structure) / Neuraminidase / Plant Extracts / Plant Roots / Salvia miltiorrhiza
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.fitote.2015.01.013
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25644525; ● Summary page in Scopus @ Elsevier: 2-s2.0-84923339307

(DOI: 10.1016/j.fitote.2015.01.013, PubMed: 25644525, Elsevier: Scopus) Naonobu Tanaka, Minami Takekata, Shin-ichiro Kurimoto, Kazuyoshi Kawazoe, Kotarou Murakami, Davaadagva Damdinjav, Enkhajargal Dorjbal and Yoshiki Kashiwada :
Algiolide A, secoiridoid glucoside from Mongolian medicinal plant Gentiana algida,
Tetrahedron Letters, Vol.56, No.6, 817-819, 2015.

(要約): A new secoiridoid glucoside, algiolide A (1), was isolated from the aerial parts of a Mongolian traditional herbal medicine Gentiana algida (Gentianaceae). The structure of 1 was elucidated on the basis of spec- troscopic analysis and chemical conversion as well as calculations of NMR and ECD spectra. Algiolide A (1) has a novel skeleton consisting of fused a,b-unsaturated-d-lactone and cyclopentene rings.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.tetlet.2014.12.107
(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-84921304975

(DOI: 10.1016/j.tetlet.2014.12.107, Elsevier: Scopus) Tsuyoshi Goto, Noritaka Hirazawa, Yoshihisa Takaishi and Yoshiki Kashiwada :
Antiparasitic effect of matrine and oxymatrine (quinolizidine alkaloids) on the ciliate Cryptocaryon irritans in the red sea bream Pagrus major.,
Aquaculture, Vol.437, 339-343, 2015.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.aquaculture.2014.12.026
(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-84920120223

(DOI: 10.1016/j.aquaculture.2014.12.026, Elsevier: Scopus) Goto Tsuyoshi, Hirazawa Noritaka, Yoshihisa Takaishi and Yoshiki Kashiwada :
Antiparasitic effects of Sophora flavescens root extracts on the ciliate, Cryptocaryon irritans,
Aquaculture, Vol.435, No.C, 173-177, 2015.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.aquaculture.2014.09.007
(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-84908539753

(DOI: 10.1016/j.aquaculture.2014.09.007, Elsevier: Scopus) Taishi Kusama, Naonobu Tanaka, Kanae Sakai, Tohru Gonoi, Jane Fromont, Yoshiki Kashiwada and Jun'ichi Kobayashi :
Agelamadins C-E, Bromopyrrole Alkaloids Comprising Oroidin and 3-Hydroxykynurenine from a Marine Sponge Agelas sp.,
Organic Letters, Vol.16, No.19, 5176-5179, 2014.

(要約): Three structurally unique bromopyrrole alkaloids, agelamadins C-E (1-3), were isolated from a marine sponge Agelas sp. Agelamadin C (1) possesses a hybrid structure of oroidin and 3-hydroxykynurenine connected through a dihydro-1,4-oxazine moiety. Agelamadins D (2) and E (3) are a C-9/C-10 diastereomer and a 10-epimer of 1, respectively. The structures of 1-3 were elucidated on the basis of spectroscopic analysis as well as application of a PGME method and a TDDFT ECD calculation. Antimicrobial activity of 1-3 was evaluated.
(出版サイトへのリンク): ● Publication site (DOI): 10.1021/ol502528m
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25247626; ● Search Scopus @ Elsevier (PMID): 25247626; ● Search Scopus @ Elsevier (DOI): 10.1021/ol502528m

(DOI: 10.1021/ol502528m, PubMed: 25247626) Chika Hashida, Naonobu Tanaka, Kazuyoshi Kawazoe, Kotarou Murakami, Han-Dong Sun, Yoshihisa Takaishi and Yoshiki Kashiwada :
Hypelodins A and B, polyprenylated benzophenones from Hypericum elodeoides.,
Journal of Natural Medicines, Vol.68, No.4, 737-742, 2014.

(要約): Two new polyprenylated benzophenones, hypelodins A (1) and B (2), were isolated from the aerial parts of the Chinese medicinal plant Hyperium elodeoides (Choisy). Their structures were elucidated on the basis of spectroscopic evidence. Hypelodin A (1) is a polyprenylated benzophenone having a tetrahydropyrane ring with three prenyl groups and one 4-methyl-1,3-pentadiene moiety, while hypelodin B (2) has a cage-like structure with a 6/6/5/7/6/5 hexacyclic ring system.
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s11418-014-0853-9
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25081326; ● Search Scopus @ Elsevier (PMID): 25081326; ● Search Scopus @ Elsevier (DOI): 10.1007/s11418-014-0853-9

(DOI: 10.1007/s11418-014-0853-9, PubMed: 25081326) Taishi Kusama, Naonobu Tanaka, Kanae Sakai, Tohru Gonoi, Jane Fromont, Yoshiki Kashiwada and Jun'ichi Kobayashi :
Agelamadins A and B, Dimeric Bromopyrrole Alkaloids from a Marine Sponge Agelas sp.,
Organic Letters, Vol.16, No.15, 3916-3918, 2014.

(要約): Two structurally unique dimeric bromopyrrole alkaloids, agelamadins A (1) and B (2), were isolated from a marine sponge Agelas sp. Agelamadins A (1) and B (2) have a structure consisting of an agelastatin-like tetracyclic moiety and an oroidin-like linear moiety in common. The structures of 1 and 2 were elucidated on the basis of spectroscopic analysis. The antimicrobial activity and cytotoxicity of agelamadins A (1) and B (2) were evaluated.
(出版サイトへのリンク): ● Publication site (DOI): 10.1021/ol501664b
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25020256; ● Summary page in Scopus @ Elsevier: 2-s2.0-84905375091

(DOI: 10.1021/ol501664b, PubMed: 25020256, Elsevier: Scopus) Hisako Sasaki, Hirofumi Shibata, Kiyoshi Imabayashi, Yoshihisa Takaishi and Yoshiki Kashiwada :
Prenylated Flavonoids from the Stems and Leaves of Desmodium caudatum and Evaluation of Their Inhibitory Activity against the Film-Forming Growth of Zygosaccharomyces rouxii F51.,
Journal of Agricultural and Food Chemistry, Vol.62, No.27, 6345-6353, 2014.

(要約): In order to provide scientific evidence for the relationship between the traditional usage, stems and leaves of Desmodium caudatum being used for protecting miso from spoilage, and its Japanese name (miso-naoshi), phytochemical study on the stems and leaves of this plant was carried out. Seven new prenylated flavonoids (1-3, 15-18), together with 19 known compounds (4-14, 19-26), were isolated, and the structures of new compounds were elucidated by extensive spectroscopic analyses. The minimum inhibitory concentrations (MICs) of 28 flavonoids, including 17 compounds (1, 2, 4, 5, 7-14, 20-22, 24, 25) isolated in this study and 11 flavonoids (27-37) previously isolated from the roots of this plant, against the film-forming yeast of Zygosaccharomyces rouxii F51 were determined. Fifteen compounds (2, 4, 5, 11, 12, 14, 21, 22, 25, 27, 28, 32-35) inhibited the film-forming growth of Z. rouxii F51 (MIC values, 7.8-62.5 g/mL), among which 2'',2''-dimethylpyran-(5'',6'':7,8)-5,2'-dihydroxy-4'-methoxy-(2R,3R)-dihydroflavonol (11) demonstrated potent inhibitory activity with an MIC value of 7.8 g/mL.
(出版サイトへのリンク): ● Publication site (DOI): 10.1021/jf5020439
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24956381; ● Summary page in Scopus @ Elsevier: 2-s2.0-84903973802

(DOI: 10.1021/jf5020439, PubMed: 24956381, Elsevier: Scopus) Shin-ichiro Kurimoto, Yoshihisa Takaishi, Fakhruddin Ali Ahmed and Yoshiki Kashiwada :
Triterpenoids from the fruits of Azadirachta indica (Meliaceae).,
Fitoterapia, Vol.92, 200-205, 2014.

(要約): Four new triterpenoids, indicalilacols A-D (1-4), were isolated from the MeOH extract of the fruits of Azadirachta indica, including a new 19(109)abeo-tirucallane derivative, two new tirucallane-type triterpenoids, and a new euphane-type triterpenoid, along with three known tirucallane-type triterpenoids. Their structures were elucidated on the basis of spectroscopic analyses. The absolute configuration of 2 was elucidated by the chemical conversion of 2 into 21-oxo-melianodiol 24,25-acetonide. Compounds 2, 6-8 exhibited moderate cytotoxicity against three human cancer cell lines, including multidrug-resistant (MDR) cancer cells (KB-C2). Although compound 5 was not cytotoxic against any of the tested cancer cell lines, 5 showed cytotoxicity against KB-C2 cells in the presence of 2.5 M colchicine, suggesting that 5 might have an MDR-reversal effect.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.fitote.2013.11.004
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24239747; ● Summary page in Scopus @ Elsevier: 2-s2.0-84890056124

(DOI: 10.1016/j.fitote.2013.11.004, PubMed: 24239747, Elsevier: Scopus) Yoshiki Kashiwada, Yuka Omichi, Shin-ichiro Kurimoto, Hirofumi Shibata, Yoshiyuki Miyake, Tsukasa Kirimoto and Yoshihisa Takaishi :
Conjugates of a secoiridoid glucoside with a phenolic glucoside from the flower buds of Lonicera japonica Thunb.,
Phytochemistry, Vol.96, 423-429, 2013.

(要約): Secoiridoid glucosides, including two conjugates with a phenolic and two conjugates with a nicotinic acid derivative (3 and 4), together with seven known secoiridoid derivatives, were isolated from flower buds of Lonicera japonica. The structures were elucidated by spectroscopic analyses. Anti-influenza activities of six isolated compounds were also evaluated by plaque assay and neuraminidase inhibitory assay.
(キーワード): Antiviral Agents / Flowers / Influenza A virus / Iridoid Glucosides / Lonicera / 分子構造 (molecular structure) / Neuraminidase / Nicotinic Acids / Phenols
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.phytochem.2013.09.021
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24120297; ● Search Scopus @ Elsevier (PMID): 24120297; ● Search Scopus @ Elsevier (DOI): 10.1016/j.phytochem.2013.09.021

(DOI: 10.1016/j.phytochem.2013.09.021, PubMed: 24120297) Yoshihiro Suyama, Shin-ichiro Kurimoto, Kazuyoshi Kawazoe, Kotarou Murakami, Han-Dong Sun, Shun-Lin Li, Yoshihisa Takaishi and Yoshiki Kashiwada :
Rigenolide A, a new secoiridoid glucoside with a cyclobutane skeleton, and three new acylated secoiridoid glucosides from Gentiana rigescens Franch.,
Fitoterapia, Vol.91, 166-172, 2013.

(要約): Rigenolide A (1), a new secoiridoid glucoside with a cyclobutane skeleton and three new acylated secoiridoid glucosides, 2'-(2,3-dihydroxybenzoyl)-gentiopicroside (2), 2'-(2,3-dihydroxybenzoyl)-swertiamarin (3), 3'-(2,3-dihydroxybenzoyl)-sweroside (4), along with two noriridoids (7 and 8) and two known secoiridoid glucosides (5 and 6), were isolated from Gentiana rigescens Franch. The structures of new compounds were elucidated by extensive spectroscopic analyses. The isolated compounds were evaluated for DPPH free-radical scavenging activity.
(キーワード): Acylation / Biphenyl Compounds / Gentiana / Iridoid Glucosides / 分子構造 (molecular structure) / Picrates / Plant Extracts / Pyrones
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.fitote.2013.08.006
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23994629; ● Search Scopus @ Elsevier (PMID): 23994629; ● Search Scopus @ Elsevier (DOI): 10.1016/j.fitote.2013.08.006

(DOI: 10.1016/j.fitote.2013.08.006, PubMed: 23994629) Takashi Ichiyanagi, Yoshiki Kashiwada, Yasuo Shida, Michiko Sekiya, Yoshihiko Hatano, Yoshihisa Takaishi and Yasumasa Ikeshiro :
Structural elucidation and biological fate of two glucuronyl metabolites of pelargonidin 3-O--D-glucopyranoside in rats.,
Journal of Agricultural and Food Chemistry, Vol.61, No.3, 569-578, 2013.

(要約): A high proportion of pelargonidin 3-O--D-glucopyranoside (Pg3G) is metabolized to glucuronides and excreted in mammal urine after ingestion of strawberry fruit, suggesting that these metabolites play important functional roles in vivo. The aim of the present study was to elucidate the structures and determine the biological fate of the two dominant metabolites of Pg3G in rats to enable an accurate discussion of the biological properties of anthocyanins. Authentic Pg3G was orally administered to rats. One pelargonidin monoglucuronide and three Pg3G-monoglucuronides (glucuronides of the glucoside) were identified together with intact Pg3G in both blood plasma and urine samples. The structures of the two dominant metabolites were elucidated as pelargonidin 3-O--D-glucuronide (Pg3GlcA) and pelargonidin 3-O--D-glucuronyl-(12)--D-glucoside by means of (1)H and (13)C nuclear magnetic resonance spectroscopy and heteronuclear multiple-bond connective spectroscopy. The bioavailability of Pg3G in its intact form was 0.31% of the orally administered dose, and 0.65% was absorbed in the Pg3GlcA form.
(出版サイトへのリンク): ● Publication site (DOI): 10.1021/jf3032793
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23256460; ● Search Scopus @ Elsevier (PMID): 23256460; ● Search Scopus @ Elsevier (DOI): 10.1021/jf3032793

(DOI: 10.1021/jf3032793, PubMed: 23256460) Kurimoto Shin-ichiro, Suzuki Kyoko, Okasaka Mamoru, Yoshiki Kashiwada, Kodzhimatov K. Olimjon and Yoshihisa Takaishi :
New sesquiterpene lactone glucosides from the roots of Ferula varia.,
Phytochemistry Letters, Vol.5, No.4, 729-733, 2012.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.phytol.2012.08.001
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1016/j.phytol.2012.08.001

(DOI: 10.1016/j.phytol.2012.08.001) Hisako Sasaki, Yoshiki Kashiwada, Hirofumi Shibata and Yoshihisa Takaishi :
Prenylated flavonoids from the roots of Desmodium caudatum and evaluation of their antifungal activity.,
Planta Medica, Vol.78, No.17, 1851-1856, 2012.

(要約): Two new prenylated flavonoids (1, 4) and two new prenylated C-methyl-flavonoids (6, 7), together with four known flavonoids (2, 3, 5, 8), were isolated from the roots of Desmodium caudatum. The structures of the new compounds were elucidated by extensive spectroscopic analyses including 1D-, 2D-NMR and MS. The antifungal activities of five compounds (1, 2, 4, 6, 8) as well as nine flavonoids (9-17) previously isolated from this plant against Aspergillus niger, Penicillium sp., Rhizopus sp., and Trichophyton sp. were evaluated. Compound 6 showed potent antifungal activity against Trichophyton sp. with a minimum inhibitory concentration (MIC) value of 1.95 µg/mL.
(キーワード): Antifungal Agents / Aspergillus niger / Fabaceae / フラボノイド (flavonoids) / Microbial Sensitivity Tests / 分子構造 (molecular structure) / Penicillium / Plant Roots / Rhizopus / Trichophyton
(出版サイトへのリンク): ● Publication site (DOI): 10.1055/s-0032-1315391
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23059627; ● Search Scopus @ Elsevier (PMID): 23059627; ● Search Scopus @ Elsevier (DOI): 10.1055/s-0032-1315391

(DOI: 10.1055/s-0032-1315391, PubMed: 23059627) Hisako Sasaki, Yoshiki Kashiwada, Hirofumi Shibata and Yoshihisa Takaishi :
Prenylated flavonoids from Desmodium caudatum and evaluation of their anti-MRSA activity.,
Phytochemistry, Vol.82, 136-142, 2012.

(要約): Seven prenylated flavonoids and a prenylated chromanochroman derivative, together with eight known flavonoids, were isolated from roots of Desmodium caudatum. The 15 structures were elucidated by extensive spectroscopic analyses. The antibacterial activity of many of other compounds was evaluated against methicillin-resistant Staphylococcus aureus (MRSA: COL and 5) by a disc diffusion method, and the minimum inhibitory concentrations (MICs) to MRSA were determined.
(キーワード): Anti-Bacterial Agents / Fabaceae / フラボノイド (flavonoids) / Methicillin-Resistant Staphylococcus aureus / Microbial Sensitivity Tests / Prenylation
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.phytochem.2012.06.007
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22800912; ● Search Scopus @ Elsevier (PMID): 22800912; ● Search Scopus @ Elsevier (DOI): 10.1016/j.phytochem.2012.06.007

(DOI: 10.1016/j.phytochem.2012.06.007, PubMed: 22800912) Tamotsu Tanaka, Ayaka Kassai, Mayumi Ohmoto, Katsuya Morito, Yoshiki Kashiwada, Yoshihisa Takaishi, Mai Urikura, Jun-ichi Morishige, Kiyoshi Satouchi and Akira Tokumura :
Quantification of phosphatidic acid in foodstuffs using TLC-imaging technique,
Journal of Agricultural and Food Chemistry, Vol.60, No.16, 4156-4161, 2012.

(要約): Apical application of lysophosphatidic acid (LPA), a growth-factor-like phospholipid, was shown to prevent or restore gastrointestinal (GI) disorders, such as diarrhea and stomach ulcer, in experimental animals. Because LPA is formed from phosphatidic acid (PA) by the activity of digestive phospholipase A(2), PA is a potential component for dietary treatment of such GI disorders. Here, we quantified PA contained in 38 foodstuffs and 3 herbs by a thin-layer-chromatography-imaging technique. Vegetables belonging to Brassicaceae, such as cabbage leaves (700 nmol/g of wet weight) and Japanese radish leaves (570 nmol/g), contained higher amounts of PA than other foodstuffs. Amounts of PA in fruits, cereals, and starchy root vegetables were below 300 nmol/g. Animal foodstuffs contained low amounts of PA (<60 nmol/g). Interestingly, leaves of Mallotus japonicas, a Japanese edible herb used for treatment of stomach ulcer, had the highest PA (1410 nmol/g) among those examined. The data shown here will be useful for the development of dietary treatment for a damaged GI tract.
(キーワード): Chromatography, Thin Layer / Food Analysis / Phosphatidic Acids
(出版サイトへのリンク): ● Publication site (DOI): 10.1021/jf300147y
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22475031; ● Summary page in Scopus @ Elsevier: 2-s2.0-84860316722

(DOI: 10.1021/jf300147y, PubMed: 22475031, Elsevier: Scopus) Yoshiki Kashiwada, Fakhruddin Ali Ahmed, Shin-ichiro Kurimoto, Sang-Yong Kim, Hirofumi Shibata, Toshihiro Fujioka and Yoshihisa Takaishi :
New α-glucosides of caffeoyl quinic acid from the leaves of Moringa oleifera Lam.,
Journal of Natural Medicines, Vol.66, No.1, 217-221, 2012.

(要約): Two new caffeoyl quinic acid α-glucosides, together with three known caffeoyl quinic acids and five known flavonoid glucosides, were isolated from the leaves of Moringa oleifera Lam. The structures of the new compounds were elucidated as 4-O-(4'-O-α-D-glucopyranosyl)-caffeoyl quinic acid (1) and 4-O-(3'-O-α-D-glucopyranosyl)-caffeoyl quinic acid (2) by spectroscopic analyses.
(キーワード): Animals / Antiviral Agents / Cell Line / Dogs / Enzyme Inhibitors / Free Radical Scavengers / Glucosides / Influenza A Virus, H1N1 Subtype / 核磁気共鳴分光法 (nuclear magnetic resonance spectroscopy) / 質量分析法 (mass spectrometry) / 分子構造 (molecular structure) / Moringa oleifera / Neuraminidase / Plant Leaves / Quinic Acid / 構造活性相関 (structureactivity relationship)
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s11418-011-0563-5
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21748486; ● Search Scopus @ Elsevier (PMID): 21748486; ● Search Scopus @ Elsevier (DOI): 10.1007/s11418-011-0563-5

(DOI: 10.1007/s11418-011-0563-5, PubMed: 21748486) Shin-ichiro Kurimoto, Yoshiki Kashiwada, Kuo-Hsiung Lee and Yoshihisa Takaishi :
Triterpenes and a triterpene glucoside from Dysoxylum cumingianum and their cytotoxicity.,
Phytochemistry, Vol.72, No.17, 2205-2211, 2011.

(要約): Six triterpenes and a triterpene glucoside were isolated from the MeOH extract of the leaves of Dysoxylum cumingianum together with three known triterpenes. Their structures were elucidated by extensive spectroscopic analyses. In cytotoxicity assays against three human cancer cell lines, including a multi-drug resistant cancer cell line (KB-C2), compounds 1, 2 and 5 demonstrated significantly enhanced cytotoxicity against KB-C2 cells in the presence of 2.5 μM colchicine, as compared with those in the absence of colchicine. This result suggested that these triterpenes might show some MDR-reversing effects.
(キーワード): Antineoplastic Agents, Phytogenic / Cell Line, Tumor / Colchicine / Drug Resistance, Multiple / Glucosides / Humans / Meliaceae / Molecular Structure / Neoplasms / Phytotherapy / Plant Extracts / Plant Leaves / Triterpenes / Tubulin Modulators
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.phytochem.2011.08.002
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21899865; ● Search Scopus @ Elsevier (PMID): 21899865; ● Search Scopus @ Elsevier (DOI): 10.1016/j.phytochem.2011.08.002

(DOI: 10.1016/j.phytochem.2011.08.002, PubMed: 21899865) Kim Sang-Yong, Yoshiki Kashiwada, Kazuyoshi Kawazoe, Kotarou Murakami, Sun Han-Dong, Li Shun-Lin and Yoshihisa Takaishi :
Spicachlorantins G-J, New Lindenane Sesquiterpenoid Dimers from the Roots of Chloranthus spicatus.,
Chemical & Pharmaceutical Bulletin, Vol.59, No.10, 1281-1284, 2011.

(要約): Four new lindenane sesquiterpenoid dimers, spicachlorantins G-J (1-4), were isolated from the roots of Chloranthus spicatus together with seven known compounds, including chloramultilide A, shizukaol B, shizukaol D, shizukaol F, shizukaol P, chlorahololide D, and cycloshizukaol A. The planar structures of the new compounds were established by 1D-, 2D-NMR, and MS analyses. The absolute configurations of these compounds were determined by analyzing rotating Overhauser enhancement and exchange spectroscopy (ROESY) and circular dichroism (CD) spectra.
(キーワード): Circular Dichroism / Dimerization / Ferns / Molecular Conformation / Molecular Structure / Plant Extracts / Plant Roots / Sesquiterpenes
(出版サイトへのリンク): ● Publication site (DOI): 10.1248/cpb.59.1281
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21963639; ● Search Scopus @ Elsevier (PMID): 21963639; ● Search Scopus @ Elsevier (DOI): 10.1248/cpb.59.1281

(DOI: 10.1248/cpb.59.1281, PubMed: 21963639) Shin-ichiro Kurimoto, Yoshiki Kashiwada, Susan L. Morris-Natschke, Kuo-Hsiung Lee and Yoshihisa Takaishi :
Dyscusins AC, Three New Steroids From the Leaves of Dysoxylum cumingianum.,
Chemical & Pharmaceutical Bulletin, Vol.59, No.10, 1303-1306, 2011.

(要約): Three new steroids dyscusins A-C (1-3), including a stigmastane-type sterol and two pregnanes, together with two known steroids were isolated from the leaves of Dysoxylum cumingianum (Meliaceae). Their structures were elucidated on the basis of extensive spectroscopic analyses. In a cytotoxicity assay, compound 1 showed ten-fold enhanced cytotoxicity against multi-drug resistant cancer cells (KB-C2) in the presence of 2.5 µM colchicine as compared with the absence of colchicine. This notable finding indicated that 1 possessed a multi-drug resistant reversal effect.
(キーワード): Antineoplastic Agents, Phytogenic / Cell Line, Tumor / Colchicine / Drug Screening Assays, Antitumor / Humans / Meliaceae / Molecular Structure / Phytotherapy / Plant Leaves / Pregnanes / Steroids / Sterols / Tubulin Modulators
(出版サイトへのリンク): ● Publication site (DOI): 10.1248/cpb.59.1303
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21963644; ● Search Scopus @ Elsevier (PMID): 21963644; ● Search Scopus @ Elsevier (DOI): 10.1248/cpb.59.1303

(DOI: 10.1248/cpb.59.1303, PubMed: 21963644) Ahmed Ali Fakhruddin, Kim Sang-Yong, Kurimoto Shin-ichiro, Sasaki Hisako, Hirofumi Shibata, Yoshiki Kashiwada and Yoshihisa Takaishi :
Biflavonoids from Flowers of Butea monosperma (Lam.) Taub.,
Heterocycles, Vol.83, No.9, 2079-2089, 2011.

(キーワード): Butea monosperma / Fabaceae / Biflavonoid / Neuraminidase / DPPH
(出版サイトへのリンク): ● Publication site (DOI): 10.3987/COM-11-12275
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1520291855472043392; ● Search Scopus @ Elsevier (DOI): 10.3987/COM-11-12275

(DOI: 10.3987/COM-11-12275, CiNii: 1520291855472043392) Yoshiki Kashiwada, Nishimura Kazuya, Kurimoto Shin-ichiro and Yoshihisa Takaishi :
New 29-nor-cycloartanes with a 3,4-seco- and a novel 2,3-seco-structure from the leaves of Sinocalycanthus chinensis.,
Bioorganic & Medicinal Chemistry, Vol.19, No.9, 2790-2796, 2011.

(要約): Eight new triterpenoids, including sinocalycanchinensins A-E (1-5) with a 3,4-seco-29-nor-cycloartane skeleton, sinocalycanchinensin F (6) possessing a novel 2,3-seco-29-nor-cycloartane skeleton, and 29-nor-cycloartanes, sinocalycanchinensins G and H (7 and 8), have been isolated from the leaves of Sinocalycanthus chinensis. Their structures were elucidated on the basis of spectroscopic examinations. The cytotoxicities of the isolated new triterpenes against a panel of human cancer cell lines, including multi-drug resistant (MDR) cancer cell lines, were also evaluated. Compound 5 demonstrated enhanced cytotoxicity against MDR KB cells in the presence of colchicine, although all the compounds showed moderate or no cytotoxicities.
(キーワード): Calycanthaceae / Cell Line, Tumor / Drug Screening Assays, Antitumor / Humans / Magnetic Resonance Spectroscopy / Molecular Conformation / Plant Leaves / Triterpenes
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.bmc.2011.03.055
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21493075; ● Search Scopus @ Elsevier (PMID): 21493075; ● Search Scopus @ Elsevier (DOI): 10.1016/j.bmc.2011.03.055

(DOI: 10.1016/j.bmc.2011.03.055, PubMed: 21493075) Xiong Juan, Taniguchi Masatoshi, Yoshiki Kashiwada, Yamagishi Takashi and Yoshihisa Takaishi :
Seven new dammarane triterpenes from the floral spikes of Betula platyphylla var. japonica.,
Journal of Natural Medicines, Vol.65, No.1, 217-223, 2011.

(要約): Seven new dammarane-type triterpenoids, including two 20(S)-hydroxy-25-methoxy-dammar-23-enes (1 and 2), two 20(S),24(R)-epoxydammaranes (3 and 4), a cabralealactone (5), and two 20(S),25-epoxydammaranes (6 and 7), together with seven known triterpenes (8-14), were isolated from the floral spikes of Betula platyphylla var. japonica. The structures for all compounds were elucidated by the analyses of extensive spectroscopic data, as well as chemical examinations.
(キーワード): Betula / Flowering Tops / Magnetic Resonance Spectroscopy / Molecular Structure / Triterpenes
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s11418-010-0462-1
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20814752; ● Search Scopus @ Elsevier (PMID): 20814752; ● Search Scopus @ Elsevier (DOI): 10.1007/s11418-010-0462-1

(DOI: 10.1007/s11418-010-0462-1, PubMed: 20814752) Kurimoto Shin-ichiro, Okasaka Mamoru, Yoshiki Kashiwada, K Olimjon Kodzhimatov and Yoshihisa Takaishi :
Four new glucosides from the aerial parts of Mediasia macrophylla,
Journal of Natural Medicines, Vol.65, No.1, 180-185, 2011.

(要約): As part of our chemical studies on the medical plants in Uzbekistan aimed at searching for new drug leads, we have examined the aerial parts of Mediasia macrophylla. This has resulted in the isolation of four new glucosides, together with 30 known compounds. The structures of new compounds were elucidated as (1'S)-(4-hydroxyphenyl) ethane-1',2'-diol 2'-O-β-glucopyranoside (1), 3-(4'-methoxyphenyl)-propanol 1-O-β-glucopyranoside (2), 2-methoxy-3-hydroxy-5-(E)-propenyl-phenol 1-O-β-glucopyranoside (3), 1-O-angeloyl-β-glucopyranose (4), on the basis of spectral analysis.
(キーワード): Apiaceae / Glucosides / Magnetic Resonance Spectroscopy / Molecular Structure / Plant Components, Aerial / Uzbekistan
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s11418-010-0444-3
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20640523; ● Search Scopus @ Elsevier (PMID): 20640523; ● Search Scopus @ Elsevier (DOI): 10.1007/s11418-010-0444-3

(DOI: 10.1007/s11418-010-0444-3, PubMed: 20640523) Xiong Juan, Yoshiki Kashiwada, Chen Chin-Ho, Qian Keduo, Morris-Natschke L. Susan, Lee Kuo-Hsiung and Yoshihisa Takaishi :
Conjugates of Betulin Derivatives with AZT as Potent Anti-HIV Agents.,
Bioorganic & Medicinal Chemistry, Vol.18, No.17, 6451-6469, 2010.

(要約): Fourteen novel conjugates of 3,28-di-O-acylbetulins with AZT were prepared as anti-HIV agents, based on our previously reported potent anti-HIV triterpene leads, including 3-O-acyl and 3,28-di-O-acylbetulins. Nine of the conjugates (49-53, 55, 56, 59, and 60) exhibited potent anti-HIV activity at the submicromolar level, with EC(50) values ranging from 0.040 to 0.098muM in HIV-1(NL4-3) infected MT-4 cells. These compounds were equipotent or more potent than 3-O-(3',3'-dimethylsuccinyl)betulinic acid (2), which is currently in Phase IIb anti-AIDS clinical trial.
(キーワード): Anti-HIV Agents / CD4-Positive T-Lymphocytes / Cell Line / HIV-1 / Humans / Triterpenes / Zidovudine
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.bmc.2010.06.092
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20673723; ● Summary page in Scopus @ Elsevier: 2-s2.0-77955982012

(DOI: 10.1016/j.bmc.2010.06.092, PubMed: 20673723, Elsevier: Scopus) Naonobu Tanaka, Otani Mio, Yoshiki Kashiwada, Yoshihisa Takaishi, Shibazaki Azusa, Gonoi Tohru, Shiro Motoo and Kobayashi Junichi :
Petiolins J-M, prenylated acylphloroglucinols from Hypericum pseudopetiolatum var. kiusianum.,
Bioorganic & Medicinal Chemistry Letters, Vol.20, No.15, 4451-4455, 2010.

(要約): Four new prenylated acylphloroglucinols, petiolins J-M (1-4), were isolated from aerial parts of Hypericum pseudopetiolatum var. kiusianum, and the structures were elucidated by spectroscopic data and a single-crystal X-ray diffraction analysis. Petiolin J (1) exhibited antimicrobial activity.
(キーワード): Anti-Bacterial Agents / Cell Line / Crystallography, X-Ray / Humans / Hypericum / Magnetic Resonance Spectroscopy / Microbial Sensitivity Tests / Molecular Conformation / Phloroglucinol / Prenylation
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.bmcl.2010.06.047
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20598881; ● Search Scopus @ Elsevier (PMID): 20598881; ● Search Scopus @ Elsevier (DOI): 10.1016/j.bmcl.2010.06.047

(DOI: 10.1016/j.bmcl.2010.06.047, PubMed: 20598881) Hiroaki Yanagawa, Junji Terao, Eiji Takeda, Yoshihisa Takaishi, Yoshiki Kashiwada, Kazuyoshi Kawazoe, Fushitani Shuji, Koichiro Tsuchiya, Aiko Yamauchi, Sato Chiho and Minoru Irahara :
Consultation clinics for complementary and alternative medicine at Japanese university hospitals: An analysis at Tokushima University Hospital,
Experimental and Therapeutic Medicine, Vol.1, No.3, 481-483, 2010.

(要約): Here, we report on a Consultation Clinic for Complementary and Alternative Medicine (CAM) which we established at Tokushima University Hospital in July of 2007 with the aim of providing person-to-person information on CAM, though not CAM therapy itself. In December of 2008, we received 55 applications for consultation, 37% concerning health foods, 37% Japanese herbal medicine (Kampo), and 26% various other topics. The consultants (nutritionists and pharmacists) communicated individually with 38 applicants; malignancies (26%) and cardiovascular disease (24%) were the main underlying concerns. To promote the quality of consultation, data was collected by means of focus group interviews concerning the perspective of the consultants. Safe and effective use of CAM requires a network of communication linking individuals, consultation teams, physicians, primary care institutions and university hospitals. To advance this goal, we plan to broaden the efforts described herein. Our findings indicate that the specific role of the consultation clinic in promoting the scientific use of CAM merits further study.
(出版サイトへのリンク): ● Publication site (DOI): 10.3892/etm_00000075
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22993564; ● Search Scopus @ Elsevier (PMID): 22993564; ● Search Scopus @ Elsevier (DOI): 10.3892/etm_00000075

(DOI: 10.3892/etm_00000075, PubMed: 22993564) Shin-ichiro Kurimoto, Mamoru Okasaka, Yoshiki Kashiwada, Olimjon Kodzhimatov and Yoshihisa Takaishi :
A new C14-polyacetylenic glucoside with an -pyrone moiety and four new C10-polyacetylenic glucosides from Mediasia macrophylla,
Phytochemistry, Vol.71, No.5-6, 688-692, 2010.

(要約): Polyacetylenic glucosides (1-5) were isolated from the MeOH extract of Mediasia macrophylla, and their structures were established by spectroscopic analyses. Compounds 2-4 were the first examples of C(10)-polyacetylenic glucosides found in the family Umbelliferae, while compound 1 was a unique polyacetylenic glucoside possessing an alpha-pyrone moiety.
(キーワード): Alkynes / Apiaceae / Glucosides / Molecular Structure / Plant Components, Aerial / Plant Extracts / Pyrones
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.phytochem.2009.12.007
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20074759; ● Search Scopus @ Elsevier (PMID): 20074759; ● Search Scopus @ Elsevier (DOI): 10.1016/j.phytochem.2009.12.007

(DOI: 10.1016/j.phytochem.2009.12.007, PubMed: 20074759) Elizabeth R. Sharlow, Todd A. Lyda, Heidi C. Dodson, Gabriela Mustata, Meredith T. Morris, Stephanie S. Leimgruber, Kuo-Hsiung Lee, Yoshiki Kashiwada, David Close, John S. Lazo and James C. Morris :
A Target-Based High Throughput Screen Yields Trypanosoma brucei Hexokinase Small Molecule Inhibitors with Antiparasitic Activity.,
PLoS Neglected Tropical Diseases, Vol.4, No.4, e659, 2010.

(要約): The parasitic protozoan Trypanosoma brucei utilizes glycolysis exclusively for ATP production during infection of the mammalian host. The first step in this metabolic pathway is mediated by hexokinase (TbHK), an enzyme essential to the parasite that transfers the gamma-phospho of ATP to a hexose. Here we describe the identification and confirmation of novel small molecule inhibitors of bacterially expressed TbHK1, one of two TbHKs expressed by T. brucei, using a high throughput screening assay. Exploiting optimized high throughput screening assay procedures, we interrogated 220,233 unique compounds and identified 239 active compounds from which ten small molecules were further characterized. Computation chemical cluster analyses indicated that six compounds were structurally related while the remaining four compounds were classified as unrelated or singletons. All ten compounds were approximately 20-17,000-fold more potent than lonidamine, a previously identified TbHK1 inhibitor. Seven compounds inhibited T. brucei blood stage form parasite growth (0.03<or=EC(50)<3 microM) with parasite specificity of the compounds being demonstrated using insect stage T. brucei parasites, Leishmania promastigotes, and mammalian cell lines. Analysis of two structurally related compounds, ebselen and SID 17387000, revealed that both were mixed inhibitors of TbHK1 with respect to ATP. Additionally, both compounds inhibited parasite lysate-derived HK activity. None of the compounds displayed structural similarity to known hexokinase inhibitors or human African trypanosomiasis therapeutics. The novel chemotypes identified here could represent leads for future therapeutic development against the African trypanosome.
(キーワード): Antiparasitic Agents / Drug Evaluation, Preclinical / Enzyme Inhibitors / Hexokinase / Humans / Protozoan Proteins / Trypanosoma brucei brucei
(出版サイトへのリンク): ● Publication site (DOI): 10.1371/journal.pntd.0000659
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20405000; ● Search Scopus @ Elsevier (PMID): 20405000; ● Search Scopus @ Elsevier (DOI): 10.1371/journal.pntd.0000659

(DOI: 10.1371/journal.pntd.0000659, PubMed: 20405000) Xiong Juan, Taniguchi Masatoshi, Yoshiki Kashiwada, Sekiya Michiko, Yamagishi Takashi and Yoshihisa Takaishi :
Papyriferic Acid Derivatives as Reversal Agents of Multidrug Resistance in Cancer Cells.,
Bioorganic & Medicinal Chemistry, Vol.18, No.8, 2964-2975, 2010.

(要約): Forty-one derivatives of papyriferic acid were prepared based on our previous finding that methyl papyriferate (3) showed potent reversing effect on cytotoxicity of colchicine against multidrug resistance (MDR) human cancer cells (KB-C2), and evaluated for their cytotoxicity and effect on reversing P-gp-mediated MDR against KB-C2 cells. 3-O-(Morpholino-beta-oxopropanoyl)-12beta-acetoxy-3alpha,25-dihydroxy-(20S,24R)-epoxydammarane (37) significantly increased the sensitivity of colchicine against KB-C2 cells by 185-fold at 5microg/mL (7.4microM), and the cytotoxicity of colchicine was recovered to nearly that of sensitive (KB) cells. The other several new amide derivatives also exhibited potent reversal activity comparable to or more potent than methyl papyriferate and verapamil.
(キーワード): Antineoplastic Agents / Cell Line, Tumor / Drug Resistance, Multiple / Drug Resistance, Neoplasm / Humans / Malonates / Morpholines / P-Glycoprotein / Triterpenes
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.bmc.2010.02.046
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20363142; ● Search Scopus @ Elsevier (PMID): 20363142; ● Search Scopus @ Elsevier (DOI): 10.1016/j.bmc.2010.02.046

(DOI: 10.1016/j.bmc.2010.02.046, PubMed: 20363142) Naonobu Tanaka, Mamemura Takuji, Abe Shuhei, Imabayashi Kiyoshi, Yoshiki Kashiwada, Yoshihisa Takaishi, Suzuki Tetsuro, Takebe Yutaka, Kubota Takaaki and Kobayashi Junichi :
Biyouxanthones A-D, prenylated xanthones from roots of Hypericum chinense,
Heterocycles, Vol.80, No.1, 613-621, 2010.

(キーワード): Hypericum chinense / Prenylated Xanthone / Antiviral Activity / Hepatitis C Virus / Clusiaceae
(出版サイトへのリンク): ● Publication site (DOI): 10.3987/COM-09-S(S)28
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1523388080321984000; ● Search Scopus @ Elsevier (DOI): 10.3987/COM-09-S(S)28

(DOI: 10.3987/COM-09-S(S)28, CiNii: 1523388080321984000) Naonobu Tanaka, Takaaki Kubota, Yoshiki Kashiwada, Yoshihisa Takaishi and Jun'ichi Kobayashi :
Petiolins F-I, benzophenone rhamnosides from Hypericum pseudopetiolatum var. kiusianum.,
Chemical & Pharmaceutical Bulletin, Vol.57, No.10, 1171-1173, 2009.

(要約): Four new benzophenone-O-rhamnosides, petiolins F-I (1-4), were isolated from aerial parts of Hypericum pseudopetiolatum var. kiusianum, and the structures were elucidated by spectroscopic data and chemical means.
(キーワード): Benzophenones / Hypericum / 核磁気共鳴分光法 (nuclear magnetic resonance spectroscopy) / Molecular Conformation / Phloroglucinol
(出版サイトへのリンク): ● Publication site (DOI): 10.1248/cpb.57.1171
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19801884; ● Search Scopus @ Elsevier (PMID): 19801884; ● Search Scopus @ Elsevier (DOI): 10.1248/cpb.57.1171

(DOI: 10.1248/cpb.57.1171, PubMed: 19801884) Naonobu Tanaka, Yoshiki Kashiwada, Sang-Yong Kim, Michiko Sekiya, Yasumasa Ikeshiro and Yoshihisa Takaishi :
Xanthones from Hypericum chinense and their cytotoxicity evaluation.,
Phytochemistry, Vol.70, No.11-12, 1456-1461, 2009.

(要約): A xanthonolignoid, 2-O-demethylkielcorin, and a phenylxanthone, chinexanthone A, were isolated from stems of Hypericum chinense together with four known xanthonolignoids and seven known xanthones. Their structures were established by spectroscopic analysis, as their optical properties and absolute stereochemistry determined. The cytotoxicities of the isolated xanthone derivatives as well as additional 32 xanthones against a panel of human cancer cell lines were also evaluated.
(キーワード): Antineoplastic Agents, Phytogenic / Cell Line, Tumor / Humans / Hypericum / 分子構造 (molecular structure) / Neoplasms / Phytotherapy / Plant Extracts / Plant Stems / Xanthones
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.phytochem.2009.08.015
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19766276; ● Search Scopus @ Elsevier (PMID): 19766276; ● Search Scopus @ Elsevier (DOI): 10.1016/j.phytochem.2009.08.015

(DOI: 10.1016/j.phytochem.2009.08.015, PubMed: 19766276) Naonobu Tanaka, Yoshiki Kashiwada, Sang Yong Kim, Waka Hashida, Michiko Sekiya, Yasumasa Ikeshiro and Yoshihisa Takaishi :
Acylphloroglucinol, biyouyanagiol, biyouyanagin B, and related spiro-lactones from Hypericum chinense.,
Journal of Natural Products, Vol.72, No.8, 1447-1452, 2009.

(要約): Biyouyanagiol (1), an acylphloroglucinol-related compound having a unique cyclopenta-1,3-dione moiety, was isolated from a Japanese traditional medicinal plant, Hypericum chinense, together with three new spiro-lactone-related derivatives, biyouyanagin B (2), 5,6-dihydrohyperolactone D (3), and 4-hydroxyhyperolactone D (4). Their structures were established on the basis of spectroscopic evidence. In a cytotoxicity assay against human cancer cell lines including multidrug-resistant (MDR) cancer cell lines, several compounds demonstrated enhanced cytotoxicity against MDR KB cells in the presence of colchicine.
(キーワード): Antineoplastic Agents, Phytogenic / Colchicine / Drug Resistance, Multiple / Drug Screening Assays, Antitumor / Humans / Hypericum japonicus / KB Cells / Lactones / Molecular Structure / Plant Leaves / Plants, Medicinal / Sesquiterpenes / Spiro Compounds
(出版サイトへのリンク): ● Publication site (DOI): 10.1021/np900109y
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19606850; ● Search Scopus @ Elsevier (PMID): 19606850; ● Search Scopus @ Elsevier (DOI): 10.1021/np900109y

(DOI: 10.1021/np900109y, PubMed: 19606850) Sang-Yong Kim, Yoshiki Kashiwada, Kazuyoshi Kawazoe, Kotarou Murakami, Han-Dong Sun, Shun-Lin Li and Yoshihisa Takaishi :
Spicachlorantins A and B, New Dimeric Sesquiterpenes from the roots of Chloranthus spicatus.,
Phytochemistry Letters, Vol.2, No.3, 110-113, 2009.

(キーワード): Chloranthaceae / Chloranthus spicatus / Ethnopharmacology / Dimeric lindenane sesquiterpene
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.phytol.2009.03.001
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1016/j.phytol.2009.03.001

(DOI: 10.1016/j.phytol.2009.03.001) Naonobu Tanaka, Kubota Takaaki, Ishiyama Haruaki, Yoshiki Kashiwada, Yoshihisa Takaishi, Ito Junji, Mikami Yuzuru, Shiro Motoo and Kobayashi Jun'ichi :
Petiolins D and E, phloroglucinol derivatives from Hypericum pseudopetiolatum var. kiusianum.,
Heterocycles, Vol.79, No.1, 917-924, 2009.

(キーワード): Hypericum pseudopetiolatum var. kiusianum / Phloroglucinol Derivative / Chromone Glucoside / Clusiaceae
(出版サイトへのリンク): ● Publication site (DOI): 10.3987/COM-08-S(D)64
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1520291853589647488; ● Search Scopus @ Elsevier (DOI): 10.3987/COM-08-S(D)64

(DOI: 10.3987/COM-08-S(D)64, CiNii: 1520291853589647488) Naonobu Tanaka, Yoshiki Kashiwada, Tatsuro Nakano, Hirofumi Shibata, Tomihiko Higuchi, Michiko Sekiya, Yasumasa Ikeshiro and Yoshihisa Takaishi :
Chromone and chromanone glucosides from Hypericum sikokumontanum and their anti-Helicobacter pylori activities.,
Phytochemistry, Vol.70, No.1, 141-146, 2009.

(要約): Chromone glucosides, takanechromones A-C (1, 2 and 5) and chromanone glucosides, named takanechromanones A and B (3 and 4), were isolated from the methanolic extracts of Hypericumsikokumontanum together with 27 known compounds. Their structures were established based on spectroscopic evidence. The isolated compounds and some chromone derivatives were assayed for antimicrobial activity against Helicobacter pylori and cytotoxicity against human cancer cell lines.
(キーワード): Anti-Bacterial Agents / Antineoplastic Agents, Phytogenic / Cell Line, Tumor / Chromones / Glucosides / Helicobacter pylori / Humans / Hypericum
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.phytochem.2008.11.006
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19121528; ● Search Scopus @ Elsevier (PMID): 19121528; ● Search Scopus @ Elsevier (DOI): 10.1016/j.phytochem.2008.11.006

(DOI: 10.1016/j.phytochem.2008.11.006, PubMed: 19121528) Sang-Yong Kim, Yoshiki Kashiwada, Kazuyoshi Kawazoe, Kotarou Murakami, Han-Dong Sun, Shun-Lin Li and Yoshihisa Takaishi :
Spicachlorantins CF, hydroperoxy dimeric sesquiterpenes from the roots of Chloranthus spicatus.,
Tetrahedron Letters, Vol.50, No.44, 6032-6035, 2009.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.tetlet.2009.08.026
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1016/j.tetlet.2009.08.026

(DOI: 10.1016/j.tetlet.2009.08.026) Freddy Ramos, Yoshihisa Takaishi, Yoshiki Kashiwada, Coralia Osorio, Carmenza Duque, Ricardo Acuna and Yoshinori Fujimoto :
Ent-3,4-seco-labdane and ent-labdane diterpenoids from Croton stipuliformis (Euphorbiaceae),
Phytochemistry, Vol.69, No.12, 2406-2410, 2008.

(要約): From a methanolic extract of the leaves of Croton stipuliformis, three ent-3,4-seco-labdanes (1-3) and an ent-labdane (4) together with the known compounds 6-hydroxynidorellol (5), maravuic acid, and sitosterol were isolated and identified from their spectroscopic data. The absolute stereochemistry of compound 4 was determined by application of Mosher's method in the NMR tube.
(キーワード): Croton / Diterpenes / Models, Molecular / Plant Leaves / Terpenes
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.phytochem.2008.05.025
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18664395; ● Search Scopus @ Elsevier (PMID): 18664395; ● Search Scopus @ Elsevier (DOI): 10.1016/j.phytochem.2008.05.025

(DOI: 10.1016/j.phytochem.2008.05.025, PubMed: 18664395) Waka Hashida, Naonobu Tanaka, Yoshiki Kashiwada, Michiki Sekiya, Yasumasa Ikeshiro and Yoshihisa Takaishi :
Tomoenones A-H, cytotoxic phloroglucinol derivatives from Hypericum ascyron,
Phytochemistry, Vol.69, No.11, 2225-2230, 2008.

(要約): Phloroglucinol derivatives tomoeones A-H (1-8) and three known compounds were isolated from leaves of Hypericum ascyron. Their structures were established based on spectroscopic analyses. They are all acylphloroglucinol derivatives possessing a spiro skeleton with geminal isoprenyl groups and a monoterpene moiety, and they are stereoisomers to each other at C-4 and C-13. They appear to be a class of phloroglucinol derivatives. Cytotoxicities of the isolated phloroglucinol derivatives against human tumor cell lines, including multidrug-resistant (MDR) cancer cell lines, were evaluated. Tomoeone F (6) demonstrated significant cytotoxicity against KB cells with an IC50 value of 6.2 microM. Compound 6 was also cytotoxic against MDR cancer cell lines (KB-C2 and K562/Adr), which was more potent than doxorubicin.
(キーワード): Cell Line, Tumor / Cell Survival / Humans / Hypericum / Magnetic Resonance Spectroscopy / Molecular Structure / Phloroglucinol / Structure-Activity Relationship
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.phytochem.2008.04.026
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18556029; ● Search Scopus @ Elsevier (PMID): 18556029; ● Search Scopus @ Elsevier (DOI): 10.1016/j.phytochem.2008.04.026

(DOI: 10.1016/j.phytochem.2008.04.026, PubMed: 18556029) Chika Hashida, Naonobu Tanaka, Yoshiki Kashiwada, Makoto Ogawa and Yoshihisa Takaishi :
Prenylated Phrologrucinol Derivatives from Hypericum perforatum var. angustifolium,
Chemical & Pharmaceutical Bulletin, Vol.56, No.8, 1164-1167, 2008.

(要約): Two new prenylated phloroglucinol derivatives and 15 known compounds were isolated from the aerial parts of Hypericum perforatum var. angustifolium. Their structures were determined on the basis of spectroscopic evidence.
(キーワード): Hypericum / Phloroglucinol / Prenylation
(出版サイトへのリンク): ● Publication site (DOI): 10.1248/cpb.56.1164
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18670119; ● Search Scopus @ Elsevier (PMID): 18670119; ● Search Scopus @ Elsevier (DOI): 10.1248/cpb.56.1164

(DOI: 10.1248/cpb.56.1164, PubMed: 18670119) Naonobu Tanaka, Takaaki Kubota, Haruaki Ishiyama, Atsushi Araki, Yoshiki Kashiwada, Yoshihisa Takaishi, Yuzuru Mikami and Jun'ichi Koyayashi :
Petiolins A-C, phloroglucinol derivatives from Hypericum pseudopetiolatum var. kiusianum,
Bioorganic & Medicinal Chemistry, Vol.16, No.10, 5619-5623, 2008.

(要約): Two new phloroglucinol derivatives possessing chromane skeleton, petiolins A (1) and B (2), and a new phloroglucinol derivative containing a dihydrofuran ring, petiolin C (3), were isolated from aerial parts of Hypericum pseudopetiolatum var. kiusianum. The gross structures of 1-3 were elucidated by spectroscopic data, and the relative stereochemistry of 3 was elucidated by NOESY data. Petiolins A-C (1-3) showed modest cytotoxicity, while petiolin C (3) exhibited antifungal activity.
(キーワード): Animals / Antifungal Agents / Cell Line, Tumor / Cell Proliferation / Drug Screening Assays, Antitumor / Humans / Hypericum / Leukemia L1210 / Magnetic Resonance Spectroscopy / Mice / Microbial Sensitivity Tests / Models, Molecular / Molecular Structure / Phloroglucinol / Stereoisomerism / Trichophyton
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.bmc.2008.03.076
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18430575; ● Search Scopus @ Elsevier (PMID): 18430575; ● Search Scopus @ Elsevier (DOI): 10.1016/j.bmc.2008.03.076

(DOI: 10.1016/j.bmc.2008.03.076, PubMed: 18430575) Mamoru Okasaka, Yoshiki Kashiwada, Olimjon K. Kodzhimatov, Ozodbek Ashurmetov and Yoshihisa Takaishi :
Monoterpene glycosides from Paeonia hybrida,
Phytochemistry, Vol.69, No.8, 1767-1772, 2008.

(要約): Monoterpene glycosides (1-5, and 7), together with 14 known compounds, were isolated from the methanol extract of the roots of Paeonia hybrida. These compounds included a paeoniflorin-related glycoside with a hybrid structure of paeoniflorin and paeonovicinoside (1), a monoterpene glucoside biogenetically related to lactiflorin (2), a paeoniflorin-related monoterpene (3), arbiflorin-related monoterpenes (4 and 5), and a tymol-related monoterpene glycoside (7). Their structures were elucidated by extensive spectroscopic examinations.
(キーワード): Benzoic Acids / Bridged Compounds / Glucosides / Glycosides / Magnetic Resonance Spectroscopy / Medicine, Chinese Traditional / Methanol / Molecular Structure / Paeonia / Plant Roots / Terpenes
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.phytochem.2008.02.016
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18400238; ● Search Scopus @ Elsevier (PMID): 18400238; ● Search Scopus @ Elsevier (DOI): 10.1016/j.phytochem.2008.02.016

(DOI: 10.1016/j.phytochem.2008.02.016, PubMed: 18400238) Naonobu Tanaka, Yoshiki Kashiwada, Michiko Sekiya, Yasumasa Ikeshiro and Yoshihisa Takaishi :
Takaneones A-C, prenylated butylphloroglucinol derivatives from Hypercum shikokumontanum,
Tetrahedron Letters, Vol.49, No.17, 2799-2803, 2008.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.tetlet.2008.02.121
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1016/j.tetlet.2008.02.121

(DOI: 10.1016/j.tetlet.2008.02.121) Shunsuke Ishida, Mamoru Okasaka, Freddy A. Ramos, Yoshiki Kashiwada, Yoshihisa Takaishi, Olimjon K. Kodzhimatov and Ozodbek Ashumetov :
New Alkaloid from the aerial parts of Condonopsis clematidea,
Journal of Natural Medicines, Vol.62, No.2, 236-238, 2008.

(要約): A new codonopsine-related alkaloid and 13 known compounds were isolated from the aerial parts of Codonopsis clematidea (Campanulaceae). The structure of the new compound was elucidated by two-dimensional nuclear magnetic resonance and other spectral examinations.
(キーワード): Alkaloids / Anisoles / Chromatography, High Pressure Liquid / Codonopsis / Magnetic Resonance Spectroscopy / Plant Components, Aerial / Plant Extracts / Pyrrolidines
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s11418-007-0219-7
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18404331; ● Search Scopus @ Elsevier (PMID): 18404331; ● Search Scopus @ Elsevier (DOI): 10.1007/s11418-007-0219-7

(DOI: 10.1007/s11418-007-0219-7, PubMed: 18404331) Michiko Sekiya, Yoshiki Kashiwada, Tomohiro Nabekura, Shuji Kitagawa, Takashi Yamagishi, Takako Yokozawa, Takashi Ichiyanagi, Yasumasa Ikeshiro and Yoshihisa Takaishi :
Effect of Triterpenoids from the Floral Spikes of Betula platyphylla var. japonica on Glycoprotein Function,
Planta Medica, Vol.73, No.15, 1558-1562, 2007.

(要約): One of the major causes of multidrug resistance (MDR) in cancer cells is over-expression of P-glycoprotein (P-gp). We studied the effects of 20 triterpenes isolated from the floral spikes of Betula platyphylla var. japonica ( B. platyphylla) on P-gp function based on our previous finding that some of them showed MDR reversing effects. We evaluated accumulations and effluxes of rhodamine 123 as a P-gp substrate with P-gp over-expressing KB-C2 cells. Among the 20 triterpenes, compounds 3, 4, 8, 9, 13, 15, and 20 increased rhodamine 123 accumulations in KB-C2 cells, and three ( 8, 13, and 20) of them also inhibited efflux of rhodamine 123 out of cells. In addition, compounds 13 and 20 showed a weak inhibitory activity of P-gp ATPase. These results suggested that MDR reversing effects of compounds 13 and 20 are partly involved in inhibition of P-gp ATPase.
(キーワード): Antineoplastic Agents, Phytogenic / Betula / Cell Line, Tumor / Drug Resistance, Neoplasm / Flowering Tops / Fluorescent Dyes / Humans / P-Glycoprotein / Phytotherapy / Plant Extracts / Rhodamine 123 / Triterpenes
(出版サイトへのリンク): ● Publication site (DOI): 10.1055/s-2007-993745
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18058609; ● Search Scopus @ Elsevier (PMID): 18058609; ● Search Scopus @ Elsevier (DOI): 10.1055/s-2007-993745

(DOI: 10.1055/s-2007-993745, PubMed: 18058609) Kyoko Suzuki, Mamoru Okasaka, Yoshiki Kashiwada, Yoshihisa Takaishi, Gisho Honda, Michiho Ito, Yoshio Takeda, Olimjon K. Kodshimatov, Ozodbek Ashurmetov, Michiko Sekiya and Yasumasa Ikeshiro :
Sesquiterpene Lactone from the Roots of Ferula varia and Their Cytotoxic Activity,,
Journal of Natural Products, Vol.70, No.12, 1915-1918, 2007.

(要約): The ethyl acetate-soluble fraction from a MeOH extract of the roots of Ferula varia gave six new sesquiterpene lactones (1-6) and five known sesquiterpenes (7-11). Their structures were established on the basis of spectroscopic evidence. The cytotoxic activities of 1-11 were evaluated against selected human cancer cell lines. Compound 4 showed significant selective cytotoxicity against multidrug-resistant cancer cells (KB-C2). The cytotoxicities of compounds 1, 3, 5, 8, and 11 against KB-C2 cells were enhanced in the presence of nontoxic concentrations of colchicine.
(キーワード): Antineoplastic Agents, Phytogenic / Colchicine / Drug Resistance, Multiple / Drug Resistance, Neoplasm / Drug Screening Assays, Antitumor / Ferula / Humans / KB Cells / Lactones / Molecular Structure / Plant Roots / Plants, Medicinal / Sesquiterpenes / Uzbekistan
(出版サイトへのリンク): ● Publication site (DOI): 10.1021/np0703996
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18052129; ● Search Scopus @ Elsevier (PMID): 18052129; ● Search Scopus @ Elsevier (DOI): 10.1021/np0703996

(DOI: 10.1021/np0703996, PubMed: 18052129) Shuji Kitagawa, Tomohiro Nabekura, Yutaka Nakamura, Tomoharu Takahashi and Yoshiki Kashiwada :
Inhibition of P-glycoprotein function by tannic acid and pentagalloylglucose.,
The Journal of Pharmacy and Pharmacology, Vol.59, No.7, 965-969, 2007.

(要約): We studied the effects of tannic acid and 1(beta),2,3,4,6-penta-O-galloyl-D-glucose (pentagalloylglucose), one of the components of tannic acid, on the P-glycoprotein (P-gp) function in multidrug-resistant P-gp over-expressing KB-C2 cells. Both tannic acid and pentagalloylglucose markedly elevated the accumulation of P-gp substrates, rhodamine 123 and daunorubicin, by inhibiting their efflux. A 19-fold increase in cellular rhodamine 123 was observed for tannic acid at 60 microM (85 microg mL(-1)) and a 21-fold increase was observed for pentagalloylglucose at 100 microM (94 microg mL(-1)). The increasing effects of these compounds in the accumulation were much larger than that of (-)epigallocatechin-3-O-gallate (EGCG), which has been revealed to have a prominent inhibitory effect on P-gp compared with other flavonoids. Analysis of verapamil-stimulated ATPase activity in membrane vesicles expressing human P-gp suggested that inhibition of P-gp function by tannic acid and pentagalloylglucose was at least partly due to ATPase inhibition of P-gp. The findings also suggested that the presence of a large number of galloyl groups in polyphenols strengthens the interaction with regulatory regions in P-gp.
(キーワード): Antibiotics, Antineoplastic / Daunorubicin / Humans / Hydrolyzable Tannins / KB Cells / P-Glycoprotein / Rhodamine 123 / Tannins
(出版サイトへのリンク): ● Publication site (DOI): 10.1211/jpp.59.7.0008
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 17637191; ● Search Scopus @ Elsevier (PMID): 17637191; ● Search Scopus @ Elsevier (DOI): 10.1211/jpp.59.7.0008

(DOI: 10.1211/jpp.59.7.0008, PubMed: 17637191) Yoshiki Kashiwada, Michiko Sekiya, Kimihisa Yamazaki, Yasumasa Ikeshiro, Toshihiro Fujioka, Takashi Yamagishi, Shuji Kitagawa and Yoshihisa Takaishi :
Triterpenoids from the Floral Spikes of Betula platyphylla var. japonica and Their Reversing Activity against Multidrug-Resistant Cancer Cells,
Journal of Natural Products, Vol.70, No.4, 623-627, 2007.

(要約): Four new triterpenes, together with 16 known triterpenes, were isolated from the floral spikes of Betula platyphylla var. japonica in a search for compounds capable of reversing multidrug resistance in cancer cells. The structures of the new triterpenes were elucidated as 3,4-seco-olean-4(23),13(18)-dien-3-oic acid (1), 3,4-seco-urs-4(23),20(30)-dien-3-oic acid (2), 3-O-methylmalonylepiocotillol II (6), and 3-O-methylmalonylcabraleahydroxylactone (16) by spectroscopic examination. The cytotoxicity of the isolated triterpenes against human cancer cell lines as well as multidrug-resistant cancer cell lines was evaluated. Most of the isolated triterpenes showed very weak cellular toxicities. Although no discernible differences were found in the cytotoxicities for the tested compounds against sensitive and resistant cell lines, the cytotoxicities for several triterpenes against multidrug-resistant cancer cell lines (KB-C2 or K562/Adr) were enhanced in the presence of nontoxic concentrations of colchicine or doxorubicin. Compound 10 reversed the cytotoxicity of colchicine against KB-C2 cells at 8.1 microM and showed comparable potency to 5 microM verapamil.
(キーワード): Antineoplastic Agents, Phytogenic / Betula / Colchicine / Drug Resistance, Multiple / Drug Resistance, Neoplasm / Drug Screening Assays, Antitumor / Humans / Japan / KB Cells / Molecular Structure / Triterpenes
(出版サイトへのリンク): ● Publication site (DOI): 10.1021/np060631s
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 17346076; ● Search Scopus @ Elsevier (PMID): 17346076; ● Search Scopus @ Elsevier (DOI): 10.1021/np060631s

(DOI: 10.1021/np060631s, PubMed: 17346076) Mamoru Okasaka, Yoshihisa Takaishi, Yoshiki Kashiwada, K. Olimjon Kodzhimatov, Ozodbek Ashurmetov, J. Ai Lin, Mark L. Consentino and Kuo-Hsiung Lee :
Terpenoids from Juniperus polycarpus var. seravschanica,
Phytochemistry, Vol.67, No.24, 2635-2640, 2006.

(要約): Two eudesmanes, two abietanes, two podocarpanes and other nine known compounds were isolated from the dried fruits of Juniperus polycarpus var. seravschanica. Their structures were established on the basis of analysis of spectroscopic evidence. Some of the isolated terpenoids showed antimalarial activity.
(キーワード): Animals / Antimalarials / Diterpenes / Diterpenes, Abietane / Fruit / Juniperus / Magnetic Resonance Spectroscopy / Molecular Structure / Plant Extracts / Plasmodium falciparum / Sesquiterpenes / Sesquiterpenes, Eudesmane / Terpenes
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.phytochem.2006.07.020
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 16956634; ● Search Scopus @ Elsevier (PMID): 16956634; ● Search Scopus @ Elsevier (DOI): 10.1016/j.phytochem.2006.07.020

(DOI: 10.1016/j.phytochem.2006.07.020, PubMed: 16956634) Yu Donglei, Sakurai Yojiro, Chen Chin-Ho, Chang Fang-Rong, Huang Li, Yoshiki Kashiwada and Lee Kuo-Hsiung :
Anti-AIDS Agents 69. Moronic Acid and Other Triterpene Derivatives as,
Journal of Medicinal Chemistry, Vol.49, No.18, 5462-5469, 2006.

(要約): In a continuing structure-activity relationship study of potent anti-HIV agents, seven new triterpene derivatives were designed, synthesized, and evaluated for in vitro antiviral activity. Among them, moronic acid derivatives 19, 20, and 21 showed significant activity in HIV-1 infected H9 lymphocytes. Compounds 19 and 20 were also evaluated against HIV-1 NL4-3 and drug resistant strains in the MT-4 cell line. Compounds 19 and 20 showed better antiviral profiles than the betulinic acid analogue 8 (PA-457), which has successfully completed a Phase IIa clinical trial. Compound 20 showed potent anti-HIV activity with EC50 values of 0.0085 íM against NL4-3, 0.021 íM against PI-R (a multiple protease inhibitor resistant strain), and 0.13 íM against FHR-2 (an HIV strain resistant to 8). Promising compound 20 has become a new lead for modification, and further development of 20-related compounds as clinical trial candidates is warranted.
(キーワード): Anti-HIV / Moronic acid
(出版サイトへのリンク): ● Publication site (DOI): 10.1021/jm0601912
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 16942019; ● Search Scopus @ Elsevier (PMID): 16942019; ● Search Scopus @ Elsevier (DOI): 10.1021/jm0601912

(DOI: 10.1021/jm0601912, PubMed: 16942019) Takashi Ichiyanagi, Yoshiki Kashiwada, Yasuo Shida, Yasumasa Ikeshiro, Kaneyuki Takao and Tetsuya Konishi :
Nasunin from Eggplant Consists of Cis-Trans Isomers of Delphinidin 3-[4-(p-Coumaroyl)-L-rhamnosyl (1 6)glucopyranoside]-5-glucopyranoside,
Journal of Agricultural and Food Chemistry, Vol.53, No.24, 9472-9477, 2005.

(要約): Two major anthocyanins were isolated from the acidified methanolic extract of eggplant (Solanum melongena L.) by column chromatography and preparative high-performance liquid chromatography. These anthocyanins were interconvertible under room light illumination condition. By means of tandem time-of-flight mass spectrometry and nuclear magnetic resonance spectroscopy, their structures were identified and elucidated as delphinidin 3-[4-(cis-p-coumaroyl)-l-rhamnosyl(1-->6)glucopyranoside]-5-glucopyranoside (compound 1) and delphinidin 3-[4-(trans-p-coumaroyl)-l-rhamnosyl-(1-->6)glucopyranoside]-5-glucopyranoside (compound 2), respectively. The results indicated that nasunin comprised cis and trans isomers of the p-coumaric acid moiety in its structure.
(キーワード): Anthocyanins / Chromatography, High Pressure Liquid / Coumaric Acids / Fruit / Magnetic Resonance Spectroscopy / Mass Spectrometry / Solanum melongena
(出版サイトへのリンク): ● Publication site (DOI): 10.1021/jf051841y
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 16302764; ● Search Scopus @ Elsevier (PMID): 16302764; ● Search Scopus @ Elsevier (DOI): 10.1021/jf051841y

(DOI: 10.1021/jf051841y, PubMed: 16302764) Shuji Kitagawa, Tomohiro Nabekura, Shizu Kamiyama, Tomoharu Takahashi, Yutaka Nakamura, Yoshiki Kashiwada and Yasumasa Ikeshiro :
Effect of Alkyl Gallates on P-glycoprotein Function,
Biochemical Pharmacology, Vol.70, No.8, 1262-1266, 2005.

(要約): In this study, we examined the effects of the food antioxidants, alkyl gallates, on the function of P-glycoprotein (P-gp) and elucidated the importance of alkyl chains and gallic acid moieties on the activity of P-gp. We examined the effects of three alkyl (n-butyl, n-octyl and n-dodecyl) gallates and their related compounds on the cellular accumulation and efflux of rhodamine 123 and daunorubicin in P-gp overexpressing KB-C2 cells. Alkyl gallates increased the cellular accumulation of these P-gp substrates dependent on their alkyl chain lengths by inhibiting the efflux of the substrates. n-Dodecylresorcinol also increased the accumulation, but its effect was less than that of n-dodecyl gallate. However, either lauric acid or n-dodecyl-beta-d-maltoside, which does not have a phenol group, did not increase the accumulation. The results indicated that both the gallic acid moiety and a long alkyl chain play important roles in the modification of P-gp function. The cytotoxicity of daunorubicin was recovered in the presence of alkyl gallates possibly due to their inhibition of P-gp function.
(キーワード): Cell Line / Daunorubicin / Gallic Acid / P-Glycoprotein / Protein Transport
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.bcp.2005.07.013
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 16139251; ● Search Scopus @ Elsevier (PMID): 16139251; ● Search Scopus @ Elsevier (DOI): 10.1016/j.bcp.2005.07.013

(DOI: 10.1016/j.bcp.2005.07.013, PubMed: 16139251) Yoshiki Kashiwada, Akihiro Aoshima, Yasumasa Ikeshiro, Yuh-Pan Chen, Hiroshi Furukawa, Masataka Itoigawa, Toshihiro Fujioka, Kunihide Mihashi, Mark L. Cosentino, L. Susan Morris-Natschke and Kuo-Hsiung Lee :
Anti-HIV Benzylisoquinoline Alkaloids and Flavonoids from the Leaves of Nelumbo nucifera, and Structure-Activity Correlation with Related Alkaloids,
Bioorganic & Medicinal Chemistry, Vol.13, No.2, 443-448, 2005.

(要約): (+)-1(R)-Coclaurine (1) and (-)-1(S)-norcoclaurine (3), together with quercetin 3-O-beta-D-glucuronide (4), were isolated from the leaves of Nelumbo nucifera (Nymphaceae), and identified as anti-HIV principles. Compounds 1 and 3 demonstrated potent anti-HIV activity with EC50 values of 0.8 and <0.8 microg/mL, respectively, and therapeutic index (TI) values of >125 and >25, respectively. Compound 4 was less potent (EC50 2 microg/mL). In a structure-activity relationship study, other benzylisoquinoline, aporphine, and bisbenzylisoquinoline alkaloids, including liensinine (14), negferine (15), and isoliensinine (16), which were previously isolated from the leaves and embryo of Nelumbo nucifera, were evaluated for anti-HIV activity. Compounds 14-16 showed potent anti-HIV activities with EC50 values of <0.8 microg/mL and TI values of >9.9, >8.6, and >6.5, respectively. Nuciferine (12), an aporphine alkaloid, had an EC50 value of 0.8 microg/mL and TI of 36. In addition, synthetic coclaurine analogs were also evaluated. Compounds 1, 3, 12, and 14-16 can serve as new leads for further development of anti-AIDS agents.
(キーワード): Alkaloids / Animals / Anti-HIV Agents / Cell Line / HIV-1 / Isoquinolines / Molecular Structure / Nelumbo / Plant Leaves / Quercetin / Structure-Activity Relationship / Tetrahydroisoquinolines
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.bmc.2004.10.020
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15598565; ● Search Scopus @ Elsevier (PMID): 15598565; ● Search Scopus @ Elsevier (DOI): 10.1016/j.bmc.2004.10.020

(DOI: 10.1016/j.bmc.2004.10.020, PubMed: 15598565) Takako Yokozawa, Akiko Satoh, Eun Ju Cho, Yoshiki Kashiwada and Yasumasa Ikeshiro :
Protective role of Coptidis Rhizoma alkaloids agaist peroxynitrite-iduced damages to renal tubular epithelial cells,
The Journal of Pharmacy and Pharmacology, Vol.57, No.3, 367-374, 2005.

(要約): A study was conducted to elucidate and compare the protective activity of alkaloids from Coptidis Rhizoma (berberine, coptisine, palmatine, epiberberine, jatrorhizine, groenlandicine and magnoflorine) using an LLC-PK(1) cell under peroxynitrite (ONOO(-)) generation model. Treatment with 3-morpholinosydnonimine (SIN-1) led to an increase in cellular ONOO(-) generation in comparison with non-treated cells. However, Coptidis Rhizoma extract and its alkaloids, except for berberine, reduced the cellular ONOO(-) level. In addition, DNA fragmentation induced by SIN-1 was significantly decreased by the extract, and also by coptisine, epiberberine, jatrorhizine, groenlandicine and magnoflorine. Moreover, treatment with berberine, coptisine, palmatine and epiberberine exerted a protective effect against G(0)/G(1)phase arrest of cell cycle induced by SIN-1. The increase in cellular ONOO(-) generation, DNA damage and disturbance of the cell cycle by SIN-1 resulted in a decrease in cell viability. However, Coptidis Rhizoma extract, epiberberine, jatrorhizine, groenlandicine and magnoflorine significantly increased cell viability even at a concentration as low as 10 microg mL(-1). These findings demonstrate that Coptidis Rhizoma extract and its alkaloids can ameliorate the cell damage associated with ONOO(-) generation in renal tubular LLCPK(1) cells, and that the various alkaloids have distinctive mechanisms of action, such as ONOO(-) scavenging, protection from DNA damage and control of the cell cycle. Furthermore, the data suggest that among the Coptidis Rhizoma alkaloids, coptisine is the most effective for protection against SIN-1-induced cellular injury in terms of its potency and content.
(キーワード): Alkaloids / Animals / Cell Survival / DNA Fragmentation / Drugs, Chinese Herbal / Kidney Tubules / LLC-PK1 Cells / Molecular Structure / Molsidomine / Peroxynitrous Acid / Swine / Urothelium
(出版サイトへのリンク): ● Publication site (DOI): 10.1211/0022357055470
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15807993; ● Search Scopus @ Elsevier (PMID): 15807993; ● Search Scopus @ Elsevier (DOI): 10.1211/0022357055470

(DOI: 10.1211/0022357055470, PubMed: 15807993) Yoshiki Kashiwada, M. Sekiya, Y. Ikeshiro, T. Fujioka, N.R. Kilgore, C.T. Wild, G.P. Allaway and K.H. Lee :
3-O-Glutaryl-dihydrobetulin and related monoacyl derivatves as potent anti-HIV agents,
Bioorganic & Medicinal Chemistry Letters, Vol.14, No.23, 5851-5853, 2004.

(要約): 3-O-Acyl-betulin and -dihydrobetulin derivatives were prepared and evaluated for anti-HIV activity. 3-O-Glutaryl-dihydrobetulin (17) demonstrated extremely potent anti-HIV activity with an EC(50) value of 2 x 10(-5) microM and a TI value of 1.12 x 10(6). 3-O-(3',3'-Dimethylsuccinyl)- and 3-O-(3',3'-dimethylglutaryl)-dihydrobetulins (15, 16) were also potent anti-HIV compounds with EC(50) values of 0.0017 and 0.0013 microM, respectively, and TI values of 16,160 and 19,530, respectively.
(キーワード): Anti-HIV Agents / HIV-1 / Humans / Triterpenes
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.bmcl.2004.09.033
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15501054; ● Search Scopus @ Elsevier (PMID): 15501054; ● Search Scopus @ Elsevier (DOI): 10.1016/j.bmcl.2004.09.033

(DOI: 10.1016/j.bmcl.2004.09.033, PubMed: 15501054) T. Ichiyanagi, M. M Rahman, Yoshiki Kashiwada, Y. Ikeshiro, Y. Shida, Y. Hatano, H. Matsumoto, M. Hirayama, T. Tsuda and T. Konishi :
Absorption and Metabolism of Delphinidin 3-O-β-D-Glucopyranoside in Rats,
Free Radical Biology and Medicine, Vol.36, No.7, 930-937, 2004.

(要約): The absorption and metabolism of delphinidin 3-O-beta-d-glucopyranoside (Dp3G), which is the most potent antioxidant among the blueberry anthocyanins, were studied in rats. Dp3G rapidly appeared in the blood plasma within 15 min of oral administration (100 mg/kg body wt). The plasma level of absorbed Dp3G showed two peaks at 15 and 60 min after ingestion and then decreased time-dependently. However, the plasma level was maintained at approximately 30 nmol/l even after 4 h. Besides the Dp3G peak, a single major metabolite peak was detected by HPLC in the blood plasma obtained at 15 min. MS and NMR spectroscopy clarified that the chemical structure of the metabolite was 4'-O-methyl delphinidin 3-O-beta-d-glucopyranoside (methylation of the 4'-OH on the delphinidin B-ring). The present finding of this unique metabolite in anthocyanin metabolism strongly suggests that methylation of the 4'-OH on the flavonoid B-ring is a common metabolic pathway for flavonoids that carry the pyrogallol structure on the B-ring, as the same type of metabolite has been reported for other flavonoids such as epigallocatechin, but not for flavonoids carrying the catechol structure.
(キーワード): Administration, Oral / Animals / Anthocyanins / Chromatography, High Pressure Liquid / Glucosides / Liver Extracts / Magnetic Resonance Spectroscopy / Male / Mass Spectrometry / Molecular Structure / Rats / Rats, Wistar / Spectrophotometry, Ultraviolet
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.freeradbiomed.2004.01.005
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15019977; ● Search Scopus @ Elsevier (PMID): 15019977; ● Search Scopus @ Elsevier (DOI): 10.1016/j.freeradbiomed.2004.01.005

(DOI: 10.1016/j.freeradbiomed.2004.01.005, PubMed: 15019977) T. Yokozawa, A. Ishida, Yoshiki Kashiwada, E.J. Cho and Y. Ikeshiro :
Coptidis Rhizoma: Protective effects against peroxynitrite-induced oxidative damage and elucidation of its active components,
The Journal of Pharmacy and Pharmacology, Vol.56, No.4, 547-556, 2004.

(要約): We have investigated the protective effects of Coptidis Rhizoma against peroxynitrite (ONOO(-))-induced oxidative damage and have elucidated the active components of this preparation. In an in-vitro system, Coptidis Rhizoma extract scavenged ONOO(-) and its precursors, nitric oxide (NO) and superoxide anion (O(2)(-)). This scavenging activity was more marked for ONOO(-) than its precursors. In addition, against 3-morpholinosydnonimine-induced cellular damage, this extract significantly reduced cellular ONOO(-) formation and increased cell viability. In an in-vivo lipopolysaccharide plus ischaemia-reperfusion system that generated ONOO(-), the administration of Coptidis Rhizoma extract at 50 and 100 mg kg(-1)/day for 30 days exerted greater inhibition of ONOO(-) than NO and O(2)(-). This suggested that it acted as a direct scavenger of ONOO(-) rather than as a scavenger of its precursors. Moreover, the suppression of the activities of the antioxidative enzymes superoxide dismutase, catalase and glutathione peroxidase was significantly attenuated by the administration of Coptidis Rhizoma extract. Furthermore, the extract ameliorated renal dysfunction judged by decreasing serum urea nitrogen and creatinine levels. To elucidate the active components of Coptidis Rhizoma extract, we evaluated and compared the effects of the phenol plus alkaloid and alkaloid fractions on ONOO-induced damage. We found that the alkaloid fraction consisting of berberine, palmatine and coptisine was the most effective at protecting against ONOO(-). We confirmed that berberine (10 and 20 mg kg(-1)/day for 10 days), the main and most active alkaloid in Coptidis Rhizoma extract, was also protective, exerting NO-, O(2)(-)- and ONOO(-)-scavenging activities. This study suggested that Coptidis Rhizoma could protect against ONOO(-)-induced oxidative damage and that this effect was mainly attributable to the constituent alkaloids, especially berberine. This study is the first to demonstrate an antioxidative effect of alkaloids, including berberine, against ONOO(-)-induced damage.
(キーワード): Alkaloids / Animals / Antioxidants / Chromatography, High Pressure Liquid / Drugs, Chinese Herbal / Free Radical Scavengers / Ischemia / Kidney / LLC-PK1 Cells / Male / Nitric Oxide / Peroxynitrous Acid / Rats / Rats, Wistar / Reperfusion / Superoxides / Swine
(出版サイトへのリンク): ● Publication site (DOI): 10.1211/0022357023024
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15099450; ● Search Scopus @ Elsevier (PMID): 15099450; ● Search Scopus @ Elsevier (DOI): 10.1211/0022357023024

(DOI: 10.1211/0022357023024, PubMed: 15099450) T. Ichiyanagi, Yoshiki Kashiwada, Y. Ikeshiro, Y. Hatano, Y. Shida, M. Horie, S. Matsugo and T. Konish :
Complete Assignment of Billberry (Vaccinium myrtillus L.) Anthocyanins Separated by Capillary Zone Electrophoresis,
Chemical & Pharmaceutical Bulletin, Vol.52, No.2, 226-229, 2004.

(要約): Capillary zone electrophoresis (CZE) mobilities of fifteen anthocyanins in bilberry extract were completely characterized. Four minor anthocyanins in bilberry extract (malvidin 3-O-alpha-L-arabinopyranoside (Mv 3-ara), peonidin 3-O-beta-D-galactopyranoside (Pn 3-gal), peonidin 3-O-alpha-L-arabinopyranoside (Pn 3-ara), and petunidin 3-O-alpha-L-arabinopyranoside (Pt 3-ara)) that remained unidentified in our previous CZE study were isolated from the bilberry extract, and the chemical structures were assigned by NMR and MS. Their CZE mobilities were then precisely examined together with those of other major anthocyanins in the extract. When the CZE mobilities of the fifteen anthocyanins assigned here were plotted against their molecular weight/numbers of free phenolic group, it was found that separation of anthocyanins by CZE is primarily determined by the type of conjugated sugar present, and secondly by the aglycon structure.
(キーワード): Anthocyanins / Electrophoresis, Capillary / Magnetic Resonance Spectroscopy / Molecular Structure / Vaccinium myrtillus
(出版サイトへのリンク): ● Publication site (DOI): 10.1248/cpb.52.226
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 14758008; ● Search Scopus @ Elsevier (PMID): 14758008; ● Search Scopus @ Elsevier (DOI): 10.1248/cpb.52.226

(DOI: 10.1248/cpb.52.226, PubMed: 14758008) I.S. Chen, Yoshiki Kashiwada, L. S. Morris-Natschke and K.H. Lee :
Plant-derived Terpenoids and Analogues as Anti-HIV Agents,
Current Topics in Medicinal Chemistry, Vol.3, No.2, 155-169, 2003.

(要約): The plant-derived terpenoids and analogues are reviewed with respect to their anti-HIV activity, structure-activity relationships, and mechanism of action. The active compounds include diterpenoid lactones, phenolic diterpenes, atisane and kaurane diterpenes, phorbol diterpenes, triterpene glycosides, friedelane triterpenes, taraxerane triterpenes, ursane triterpenes, lanostane triterpene, lupane triterpenes, seco-ring A triterpenes, degraded triterpenes, and cucurbitacin triterpenes. Positive new leads for drug development will be highlighted.
(キーワード): Anti-HIV Agents / Plants / Terpenes
(出版サイトへのリンク): ● Publication site (DOI): 10.2174/1568026033392435
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12570771; ● Search Scopus @ Elsevier (PMID): 12570771; ● Search Scopus @ Elsevier (DOI): 10.2174/1568026033392435

(DOI: 10.2174/1568026033392435, PubMed: 12570771) I.C. Sun, C.H Chen, Yoshiki Kashiwada, J.H. Wu, H.K. Wang and K.H. Lee :
Anti-AIDS agents 49. Synthesis, anti-HIV, and anti-fusion activities of IC9564 analogues based on betulinic acid.,
Journal of Medicinal Chemistry, Vol.45, No.19, 4271-4275, 2002.

(要約): The betulinic acid derivative IC9564 inhibits human immunodeficiency virus (HIV)-1 entry. Among a series of IC9564 derivatives, 5 and 20 were the most promising compounds against HIV infection with EC(50) values of 0.33 and 0.46 microM, respectively. Both compounds inhibited syncytium formation with EC(50) values of 0.40 and 0.33 microM, respectively. The comparable EC(50) values in the two assays suggested that these compounds are fusion inhibitors. The structure-activity relationship data also indicated that a double bond in IC9564 can be eliminated and the statine moiety can be replaced with L-leucine while retaining anti-HIV activity.
(キーワード): Amides / Animals / Anti-HIV Agents / COS Cells / Cercopithecus aethiops / HIV Fusion Inhibitors / HIV-1 / Leucine / Membrane Fusion / Structure-Activity Relationship / Triterpenes
(出版サイトへのリンク): ● Publication site (DOI): 10.1021/jm020069c
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12213068; ● Search Scopus @ Elsevier (PMID): 12213068; ● Search Scopus @ Elsevier (DOI): 10.1021/jm020069c

(DOI: 10.1021/jm020069c, PubMed: 12213068) T. Yokozawa, Yoshiki Kashiwada, M. Hattori and H.Y. Chung :
Study on the Components of Luobuma with Peroxynitrite-Scavenging,
Biological & Pharmaceutical Bulletin, Vol.25, No.6, 748-752, 2002.

(要約): The origin of the antioxidant activity of Luobuma aqueous extract was examined by measuring the peroxynitrite (ONOO^-)-eliminating activities of fractions of this extract obtained by Sephadex LH-20 column chromatography. Three of the four fractions obtained, i.e., those excluding the H_2O-eluted fraction, were found to possess ONOO^-eliminating activity. These three fractions were combined and fractionated again by Sephadex LH-20 column chromatography, which yielded five fractions. Seven different compounds were isolated from two of these five fractions with high activity. Epigallocatechin-(4β-8)-epicatechin showed the highest ONOO^- -eliminating activity.
(キーワード): Luobuma / leaf / peroxynitrite / epigallocatechin-(4β-8)-epicatechin
(出版サイトへのリンク): ● Publication site (DOI): 10.1248/bpb.25.748
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12081141; ● CiNii @ 国立情報学研究所 (CRID): 1390001204628292352; ● Search Scopus @ Elsevier (PMID): 12081141; ● Search Scopus @ Elsevier (DOI): 10.1248/bpb.25.748

(DOI: 10.1248/bpb.25.748, PubMed: 12081141, CiNii: 1390001204628292352) I. Abe, Y. Kashiwagi, H. Noguchi, T. Tanaka, Y. Ikeshiro and Yoshiki Kashiwada :
Ellagitannins and hexahydroxydiphenoyl esters as inhibitors of vertebrate squalene epoxidase.,
Journal of Natural Products, Vol.64, No.8, 1010-1014, 2001.

(要約): Ellagitannins isolated from various plant sources as well as newly synthesized n-alkyl (C(1)-C(18)) esters of hexahydroxydiphenyl (HHDP) dicarboxylic acid were evaluated as enzyme inhibitors of recombinant rat squalene epoxidase, a rate-limiting enzyme of cholesterol biosynthesis. Among the ellagitannins tested, pedunculagin (IC(50) = 2.0 microM) and eugeniin (IC(50) = 1.6 microM), both containing (S)-HHDP ester group(s), showed remarkable inhibition, which was more potent than those of previously reported substrate analogue inhibitors. Furthermore, ellagic acid (IC(50) = 2.0 microM), a bislactone formed by hydrolytic release of a HHDP group from ellagitannins, was also a good inhibitor of the enzyme. On the other hand, the synthetic HHDP esters with C(6) (IC(50) = 0.93 microM) and C(8) alkyl side chains (IC(50) = 0.83 microM) showed potent enzyme inhibition at the submicromolar concentration range, while esters with shorter chain lengths (C(1)-C(4)) and a C(18) ester exhibited moderate inhibition (IC(50) = 8-47 microM).
(キーワード): Animals / Biphenyl Compounds / Chromatography, Thin Layer / Enzyme Inhibitors / Esters / Farnesyl-Diphosphate Farnesyltransferase / Hydrolyzable Tannins / Molecular Structure / Rats / Recombinant Proteins / Squalene / Structure-Activity Relationship / Substrate Specificity / Tannins
(出版サイトへのリンク): ● Publication site (DOI): 10.1021/np010100y
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11520216; ● Search Scopus @ Elsevier (PMID): 11520216; ● Search Scopus @ Elsevier (DOI): 10.1021/np010100y

(DOI: 10.1021/np010100y, PubMed: 11520216) T. Kanamoto, Yoshiki Kashiwada, K. Kanbara, K. Gotoh, M. Yoshimori, T. Goto, K. Sano and H. Nakashima :
Anti-Human Immunodeficiency Virus Activity of YK-FH312 (a Betulinic Acid Derivative), a Novel Compound Blocking Viral Maturation,
Antimicrobial Agents and Chemotherapy, Vol.45, No.4, 1225-1230, 2001.

(要約): Betulinic acid, a triterpenoid isolated from the methyl alcohol extract of the leaves of Syzigium claviflorum, was found to have a potent inhibitory activity against human immunodeficiency virus type 1 (HIV-1). Betulinic acid derivatives were synthesized to enhance the anti-HIV activity. Among the derivatives, 3-O-(3',3'-dimethylsuccinyl) betulinic acid, designated YK-FH312, showed the highest activity against HIV-induced cytopathic effects in HIV-1-infected MT-4 cells. To determine the step(s) of HIV replication affected by YK-FH312, a syncytium formation inhibition assay in MOLT-4/HIV-1(IIIB) and MOLT-4 coculture, a multinuclear-activation-of-galactosidase-indicator (MAGI) assay in MAGI-CCR5 cells, electron microscopic observation, and a time-of-addition assay were performed. In the syncytium formation inhibition assay or in the MAGI assay for de novo infection, the compound did not show inhibitory effects against HIV replication. Conversely, no virions were detected in HIV-1-infected cell cultures treated with YK-FH312 either by electron microscopic observation or by viral yield in the supernatant. In accordance with a p24 enzyme-linked immunosorbent assay of culture supernatant in the time-of-addition assay, YK-FH312 inhibited virus expression in the supernatant when it was added 18 h postinfection. However, Western blot analysis of the cells in the time-of-addition assay revealed that the production of viral proteins in the cells was not inhibited completely by YK-FH312. These results suggest that YK-FH312 might affect the step(s) of virion assembly and/or budding of virions, and this is a novel mechanism of action of an anti-HIV compound.
(キーワード): Anti-HIV Agents / Cell Fusion / Formazans / Giant Cells / HIV-1 / Humans / Microbial Sensitivity Tests / Tetrazolium Salts / Time Factors / Triterpenes / Tumor Cells, Cultured / Viral Proteins / Virion
(出版サイトへのリンク): ● Publication site (DOI): 10.1128/AAC.45.4.1225-1230.2001
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11257038; ● Summary page in Scopus @ Elsevier: 2-s2.0-0035087062

(DOI: 10.1128/AAC.45.4.1225-1230.2001, PubMed: 11257038, Elsevier: Scopus) S. Tanaka, Y. Sakata, K. Morimoto, Y. Tambe, Y. Watanabe, G. Honda, M. Tabata, T. Oshima, T. Masuda, T. Umezawa, M. Shimada, N. Nagakura, W. Kamisako, Yoshiki Kashiwada and Y. Ikeshiro :
Influence of Natural and Synthetic Compounds on Cell Surface Expression of Cell Adhesion Molecules, ICAM-1 and VCAM-1,
Planta Medica, Vol.67, No.2, 108-113, 2001.

(要約): Various natural and synthetic compounds including alkaloids, terpenoids and phenolics were tested for inhibition of the cell surface expression of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1), both of which are crucial in the regulation of immune response and inflammation. Of 40 compounds tested, two compounds significantly downregulated the expression of VCAM-1 on murine endothelial cells (F-2) and ten compounds that of ICAM-1 on mouse myeloid leukemia cells (M1). Sanguinarine chloride (5) and isoliquiritigenin (13) were capable of lowering the levels of both ICAM-1 and VCAM-1. The structure-activity relationships study on chalcone and flavone derivatives related to 13 suggested that the inhibitory activity of the chalcone derivatives is attributable to the 4-hydroxy group as well as the possible coplanarity between the phenyl ring and the adjacent conjugated ketone.
(キーワード): Alkaloids / Animals / Anti-Inflammatory Agents, Non-Steroidal / Benzophenanthridines / Chalcone / Chalcones / Intercellular Adhesion Molecule-1 / Isoquinolines / Mice / Mice, Inbred Strains / Molecular Structure / Phenols / Plants, Medicinal / Structure-Activity Relationship / Terpenes / Tumor Cells, Cultured / Vascular Cell Adhesion Molecule-1
(出版サイトへのリンク): ● Publication site (DOI): 10.1055/s-2001-11514
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11301853; ● Summary page in Scopus @ Elsevier: 2-s2.0-0035085206

(DOI: 10.1055/s-2001-11514, PubMed: 11301853, Elsevier: Scopus) Yoshiki Kashiwada, J. Chiyo, Y. Ikeshiro, T. Nagao, H. Okabe, L.M. Cosentino, K. Fowke, S.M. Morris-Natschke and S.M. Morris-Natschke :
3,28-Di-O-(Dimethylsuccinyl)-Betulin Isomers as Anti-HIV Agents,
Bioorganic & Medicinal Chemistry Letters, Vol.11, No.2, 183-185, 2001.

(要約): Four isomers of 3,28-di-O-(dimethylsuccinyl)-betulin were prepared and evaluated for anti-HIV activity against HIV-1 replication in H9 lymphocyte cells. 3-O-(3',3'-Dimethylsuccinyl)-28-O-(2", 2"-dimethvlsuccinyl)-betulin (11) was the most potent anti-HIV compound with an EC5, value of 0.00087 microM and a TI value of 42,400.
(キーワード): Anti-HIV Agents / Cell Division / Cell Line / Combinatorial Chemistry Techniques / HIV-1 / Humans / Inhibitory Concentration 50 / Isomerism / Lymphocytes / Structure-Activity Relationship / Succinic Acid / Therapeutic Equivalency / Triterpenes
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0960-894X(00)00635-1
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11206454; ● Summary page in Scopus @ Elsevier: 2-s2.0-0035931554

(DOI: 10.1016/S0960-894X(00)00635-1, PubMed: 11206454, Elsevier: Scopus) Yoshiki Kashiwada, Y. Yamazaki, Y. Ikeshiro, T. Yamagishi, T. Fujioka, K. Mihashi, K. Mizuki, L.M. Cosentino, K. Fowke and K.H. Lee :
Isolation of Rhododaurichromanic Acid B and the Anti-HIV Principles Rhododaurichromanic Acid A and Rhododaurichromenic Acid from Rhododendron dauricum,
Tetrahedron, Vol.57, No.8, 1559-1563, 2001.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0040-4020(00)01144-3
(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-0035906029

(DOI: 10.1016/S0040-4020(00)01144-3, Elsevier: Scopus) Yoshiki Kashiwada, K. Takanaka, H. Tsukada, Y. Miwa, T. Taga, S. Tanaka and Y. Ikeshiro :
Sesquiterpene Glucosides from Anti-Leukotriene B4 Release Fraction of Taraxacum officinale,
Journal of Asian Natural Products Research, Vol.3, No.3, 191-197, 2001.

(要約): Chemical examination of the MeOH extract of the root of Taraxacum officinale, which exhibited inhibitory activity on the formation of leukotriene B4 from activated human neutrophils, has resulted in the isolation of 14-O-beta-D-glucosyl-11,13-dihydro-taraxinic acid (1) and 14-O-beta-D-glucosyl-taraxinic acid (2). The absolute stereostructure of 1 has been established by X-ray chrystallographic examination.
(キーワード): Anti-HIV Agents / Asteraceae / Calcimycin / Cells, Cultured / Chromatography, High Pressure Liquid / Chromatography, Thin Layer / Crystallography, X-Ray / Dose-Response Relationship, Drug / Glucosides / HIV-1 / HeLa Cells / Humans / Inflammation / Japan / Leukotriene B4 / Molecular Conformation / Molecular Structure / Neutrophils / Nuclear Magnetic Resonance, Biomolecular / Plant Extracts / Plant Roots / Plants, Medicinal / Sesquiterpenes / Stereoisomerism / Structure-Activity Relationship
(出版サイトへのリンク): ● Publication site (DOI): 10.1080/10286020108041390
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11491394; ● Summary page in Scopus @ Elsevier: 2-s2.0-0034925990

(DOI: 10.1080/10286020108041390, PubMed: 11491394, Elsevier: Scopus)

MISC

川添和義, 伏谷秀治, 柏田良樹, 佐々木久子, 大道由佳, 栗本慎一郎, 篠崎陽介, 柴山恵美子, 関田倫彦, 金子礼, 洲山佳寛, 高岸佐和, 中野芙佐子, 平田藍, 宮崎祐樹, 田島壮一郎, 櫻田巧, 中川博之, 田岡寛之, 足立麻美, 柴田高洋, 岡田直人, 継岡知美, 淵上美由紀, 小中健, 今林潔, 今林優佳, 高石喜久, 水口和生 :
つるぎ町一宇地区の民間薬調査,
阿波学会紀要, No.57, 89-98, 2011年. 川添和義, 伏谷秀治, 柏田良樹, 田中直伸, 岡坂衛, 石田俊介, 鎌倉孝法, 佐藤昌俊, 橋田千佳, 西迫寛隆, 田島壮一郎, 森剛志, 鈴木恭子, 橋田和佳, 部屋衣美子, 高田千絵, 遠藤友香, 金尚永, 田岡寛之, 西村和也, 高石喜久, 水口和生 :
三好市東祖谷地区の民間薬調査,
阿波学会紀要, No.53, 87-98, 2007年.

総説・解説

Naonobu Tanaka and Yoshiki Kashiwada :
Phytochemical studies on traditional herbal medicines based on the ethnopharmacological information obtained by field studies,
Journal of Natural Medicines, Vol.75, No.4, 762-783, Sep. 2021.

(要約): Traditional herbal medicines, which have been used in the matured traditional medical systems as well as those have been used in ethnic medical systems, are invaluable resources of drug seeds. Ethnobotanical and ethnopharmacological survey may provide useful information of these herbal medicines, which are valuable for searching new bioactive molecules. From this viewpoint, we have been performing the ethnobotanical and ethnopharmacological field studies in Yunnan Province and Guangxi Zhuang Autonomous Region, China, and Mongolia. Phytochemical studies on traditional herbal medicines were performed based on the information obtained by our ethnobotanical survey. Herbal medicines used in Uzbekistan and Bangladesh were also investigated on the basis of the ethnopharmacological information obtained from collaborative researchers in the respective regions. Some studies were carried out for searching active substance(s) based on bioassay-guided fractionation and isolation. Over 150 new molecules were isolated in these studies, and their various biological activities were also demonstrated. This review summarizes the results of phytochemical studies of those traditional herbal medicines as well as biological activities of the isolated molecules.
(徳島大学機関リポジトリ): ● Metadata: 116555
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s11418-021-01545-7
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34255289; ● Search Scopus @ Elsevier (PMID): 34255289; ● Search Scopus @ Elsevier (DOI): 10.1007/s11418-021-01545-7

(徳島大学機関リポジトリ: 116555, DOI: 10.1007/s11418-021-01545-7, PubMed: 34255289) Naonobu Tanaka and Yoshiki Kashiwada :
Characteristic metabolites of Hypericum plants: their chemical structures and biological activities,
Journal of Natural Medicines, Vol.75, No.3, 423-433, Jun. 2021.

(要約): Plants belonging to the genus Hypericum (Hypericaceae) are recognized as an abundant source of natural products with interesting chemical structures and intriguing biological activities. In the course of our continuing study on constituents of Hypericum plants, aiming at searching natural product-based lead compounds for therapeutic agents, we have isolated more than 100 new characteristic metabolites classified as prenylated acylphloroglucinols, meroterpenes, ketides, dibenzo-1,4-dioxane derivatives, and xanthones including prenylated xanthones, phenylxanthones, and xanthonolignoids from 11 Hypericum plants and one Triadenum plant collected in Japan, China, and Uzbekistan or cultivated in Japan. This review summarizes their chemical structures and biological activities.
(キーワード): Biological Products / China / Hypericum / Japan / Molecular Structure / Phytochemicals / Prenylation / Uzbekistan
(徳島大学機関リポジトリ): ● Metadata: 116554
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s11418-021-01489-y
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33555487; ● CiNii @ 国立情報学研究所 (CRID): 1050572244982248960; ● Search Scopus @ Elsevier (PMID): 33555487; ● Search Scopus @ Elsevier (DOI): 10.1007/s11418-021-01489-y

(徳島大学機関リポジトリ: 116554, DOI: 10.1007/s11418-021-01489-y, PubMed: 33555487, CiNii: 1050572244982248960) Naonobu Tanaka, Kusama Taishi, Yoshiki Kashiwada and Kobayashi Jun'ichi :
Bromopyrrole alkaloids from Okinawan marine sponges Agelas spp.,
Chemical & Pharmaceutical Bulletin, Vol.64, No.7, 691-694, Jul. 2016.

(要約): In our continuing study for structurally and biogenetically interesting natural products from marine organisms, Okinawan marine sponges Agelas spp. were investigated, resulting in the isolation of 18 unique alkaloids including five dimeric bromopyrrole alkaloids (1-5), ten monomeric bromopyrrole alkaloids (6-15), and three conjugates of monomeric bromopyrrole alkaloid and hydroxykynurenine (16-18). In this mini-review, the isolation, structure elucidation, and antimicrobial activities of these alkaloids are summarized.
(出版サイトへのリンク): ● Publication site (DOI): 10.1248/cpb.c16-00245
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27373625; ● Summary page in Scopus @ Elsevier: 2-s2.0-84977581449

(DOI: 10.1248/cpb.c16-00245, PubMed: 27373625, Elsevier: Scopus) 嶋林三郎, 柏田良樹 :
<講座:抗菌製品を創る>抗菌剤の種類，特徴とその動向; 天然系抗菌剤,
防菌防黴誌, Vol.36, No.5, 323-333, 2008年5月.

(要約): 天然系抗菌剤を概括し，その有効成分，化学構造式と用途を紹介する．
(キーワード): 天然系抗菌剤 / 精油 / 芳香族化合物 / テルペノイド / 抗菌作用

Ichikawa Haruyo, Nakamura Yutaka, Yoshiki Kashiwada and Aggarwal B. Bharat :
Anticancer Drugs Designed by Mother Nature: Ancient Drugs but Modern Targets,
Current Pharmaceutical Design, Vol.13, No.33, 3400-3416, Nov. 2007.

(要約): Nuclear factor-kappaBeta (NF-kappaBeta) is a transcription factor that is activated in response to various inflammatory stimuli such as cytokines, growth factors, hormones, mitogens, carcinogens, chemotherapeutic agents, viral products, eukaryotic parasites, endotoxin, fatty acids, metals, radiation, hypoxia, and psychological, physical, oxidative, and chemical stresses. In addition, constitutively active NF-kappaBeta is frequently encountered in a wide variety of tumors. Furthermore, NF-kappaBeta activation has been shown to regulate the expression of over 400 genes involved in cellular transformation, proliferation, inflammation, viral replication, antiapoptosis, angiogenesis, invasion and metastasis, oxidative stress, and osteoclastogenesis. Therefore, because of the critical role NF-kappaBeta plays in the pathogenesis of cancer, specific inhibitors of this factor are being sought. Agents that prevent cancer or inflammation have been found to suppress NF-kappaBeta activation. Numerous reports indicate that ancient plants and their components are potent as NF-kappaB inibitors. However, ancient medicine such as traditional Chinese medicine, Kampo, Ayurveda requires rediscovery in light of our current knowledge of allopathic (modern) medicine for the therapeutic and preventive purpose. In this review, we present evidence that numerous agents identified from fruits and vegetables can interfere with NF-kappaBeta pathway. The structure of drugs and their relationship with NF-kappaBeta inhibitory activity is discussed.
(キーワード): Animals / Antineoplastic Agents, Phytogenic / Biological Agents / Drug Delivery Systems / Herbal Medicine / Humans / NF-kappa B / Neoplasms / Phytotherapy
(出版サイトへのリンク): ● Publication site (DOI): 10.2174/138161207782360492
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18045194; ● Search Scopus @ Elsevier (PMID): 18045194; ● Search Scopus @ Elsevier (DOI): 10.2174/138161207782360492

(DOI: 10.2174/138161207782360492, PubMed: 18045194)

講演・発表

Yuki Yoshino, Naonobu Tanaka, Kanji Niwa, Daisuke Tsuji, Kouji Itou and Yoshiki Kashiwada :
Phytochemical study on the roots of Ferula communis (5),
The 11th JSP CSP KSP Joint Symposium on Pharmacognosy, 65, Tokyo, Sep. 2021. SHIMOMOTO Yusei, Naonobu Tanaka, Kanji Niwa, Daisuke Tsuji, Kouji Itou and Yoshiki Kashiwada :
Studies on the constituents of Hypericum plants (53): Structures and biological activities on dibenzo-1,4-dioxane derivatives isolated from the roots of Hypericum ascyron,
The 11th JSP CSP KSP Joint Symposium on Pharmacognosy, 64, Tokyo, Sep. 2021. Sakura Takahashi, Naonobu Tanaka, Seita Kajihara, Kanji Niwa, Daisuke Tsuji, Kouji Itou and Yoshiki Kashiwada :
Studies on Uzbek medicinal plants (39): New norditerpenes from Perovskia scrophulariifolia,
The 11th JSP CSP KSP Joint Symposium on Pharmacognosy, 63, Tokyo, Sep. 2021. Sanghoon Lee, Naonobu Tanaka, 小林淳一 and Yoshiki Kashiwada :
New diterpene alkaloids and bromopyrrole alkaloids from Okinawan marine sponge Agelas spp.,
The 10th KSP-JSP-CSP Joint Symposium, 132, Seoul, Nov. 2018. Licht Miyamoto, Aihara Haruna, Xu Wenting, Jin Meina, Tomida Yosuke, Yamaoka Tomomi, Tanaka Naonobu, Ikeda Yasumasa, Toshiaki Tamaki, Yoshiki Kashiwada and Koichiro Tsuchiya :
A limonene-derivative purified from peels of Citrus Sudachi ameliorates lipid and glucose metabolism through upregulating sirt1,
World Congress of Pharmacology, Kyoto, Jul. 2018. Kazuko YORITA, Sumire Kurosawa, Yuri Yoshida, Yoshiki Kashiwada, Shigeki Sano, Akira Otaka and Kiyoshi Fukui :
Screening of the effectors for human D-amino acid oxidase and the analyses of structure-activity relationships,
The 19th triennial International Symposium on Flavins and Flavoproteins, Groningen, Jul. 2017. Koichiro Tsuchiya, Aihara Haruna, Xu Wenting, Jin Meina, Tomida Yosuke, Yamaoka Tomomi, Naonobu Tanaka, Yasumasa Ikeda, Akira Shigenaga, Akira Otaka, Toshiaki Tamaki, Yoshiki Kashiwada and Koichiro Tsuchiya :
A limonene-derivative from Sudachi peel activates sirt1 and improves lipid and glucose metabolism in high fat diet-fed mice.,
欧州糖尿病学会, Dec. 2016. Niwa Kanji, Naonobu Tanaka and Yoshiki Kashiwada :
Studies on the constituents Hypericum plants (43): Meroterpenes from the leaves of Hypericum chinense,
Planta Medica, Copenhagen, Jul. 2016. Wada Shizuka, Naonobu Tanaka, Chen Chin-Ho, Morris-Natschke L. Susan, Lee Kuo-Hsing and Yoshiki Kashiwada :
Anti-HIV natural products (28): preparation of conjugate for 3-O-acyl betulin derivative and AZT as anti-HIV agents,
Planta Medica, Copenhagen, Jul. 2016. Naonobu Tanaka, Kusama Taishi, Kobayashi Jun'ichi and Yoshiki Kashiwada :
Agelamadins, bromopyrrole alkaloids from Okinawan marine sponges Agelas spp.,
Planta Medica, Copenhagen, Jul. 2016. 宮本理人, 粟飯原遥奈, 許文てい, ジン美娜, 冨田洋介, 山岡朋美, 田中直伸, 池田康将, 玉置俊晃, 柏田良樹, 土屋浩一郎 :
スダチ果皮からの抗メタボリックシンドローム活性を有する物質の同定,
糖尿病, No.59, 京都, 2016年. Yoshiki Kashiwada and Naonobu Tanaka :
Studies on Chinese and Mongolian traditional medicinal plants,
International Conference on Conservation of Biodiversity and Sustainable Use of Tropical and Subtropical Plants, 83, Nov. 2015. Wenting Xu, Licht Miyamoto, Haruna Aihara, Tomomi Yamaoka, Keisuke Ishizawa, Toshiaki Tamaki, Yoshiki Kashiwada and Koichiro Tsuchiya :
The Mechanism of Citrus sudachi Peel Extract Exerts Lipid Reducing Effect in Cells,
2015.10.19-22 The 10th IAGG Asia / Oceania Congress of Gerontology and Geriatrics 2015, Chiang Mai, Oct. 2015. 宮本理人, 粟飯原遥奈, Wenting Xu, Meina Jin, 冨田洋介, 山岡朋美, 田中直伸, 池田康将, 重永章, 大髙章, 玉置俊晃, 柏田良樹, 土屋浩一郎 :
リモネン誘導体によるsirt1活性化を介した脂質低下作用,
日本肥満学会，アジアオセアニア糖尿病学会, 名古屋, 2015年10月. Licht Miyamoto, Haruna Aihara, Wenting Xu, Meina Jin, Yosuke Tomida, Tomomi Yamaoka, Naonobu Tanaka, Yasumasa Ikeda, Akira Shigenaga, Akira Otaka, Toshiaki Tamaki, Yoshiki Kashiwada and Koichiro Tsuchiya :
Limonene-derivative Ameliorates Lipid Profiles by Upregulation of Sirt1 Activity and Expression in Cultured Cells and High Fat Diet-Fed Mice,
American diabetes association, Boston, Jun. 2015. Naonobu Tanaka, Eri Tsuji, Yoshiki Kashiwada and Jun'ichi Kobayashi :
Structures of hikiokoshins AI, diterpenes from the leaves of Isodon japonicus,
The 8th JSP-CCTCNM-KSP Joint Symposium on Pharmacognosy, 96, Fukuoka, Sep. 2014. Natsuki Kobayakawa, Ai Hirata, Sang-Yong Kim, Naonobu Tanaka, Hirofumi Shibata and Yoshiki Kashiwada :
Plant-derived anti-influenza A virus agents: Study on the roots of Salvia miltiorrhiza,
The 8th JSP-CCTCNM-KSP Joint Symposium on Pharmacognosy, 87, Fukuoka, Sep. 2014. Mamiko Ito, Naonobu Tanaka, Shin-ichiro Kurimoto, Enkhjargal Dorival, Davaadagva Damdinjav and Yoshiki Kashiwada :
Study on the constituents of Hypericum plants (38): structures of prenylated coumarins from H. perforatum,
The 8th JSP-CCTCNM-KSP Joint Symposium on Pharmacognosy, 97, Fukuoka, Sep. 2014. Naonobu Tanaka, Jun'ichi Kobayashi and Yoshiki Kashiwada :
Meroterpenoids from Hypericum plants,
Planta Medica, Vol.80, 784, Oxford, Mississipi, USA, Aug. 2014.

(出版サイトへのリンク): ● Publication site (DOI): 10.1055/s-0034-1382456
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1055/s-0034-1382456

(DOI: 10.1055/s-0034-1382456) Sang-Yong Kim, Naonobu Tanaka, Yoshiki Kashiwada, Yoshihisa Takaishi, Jun'ichi Kobayashi and Mareshige Kojoma :
Studies on the constituents of Chloranthus japonicus sieb.,
Planta Medica, Vol.80, 784, Oxford, Mississipi, USA, Aug. 2014.

(出版サイトへのリンク): ● Publication site (DOI): 10.1055/s-0034-1382457
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1055/s-0034-1382457

(DOI: 10.1055/s-0034-1382457) Yoshihiro Suyama, Naonobu Tanaka, Shin-ichiro Kurimoto, Kazuyoshi Kawazoe, Kotarou Murakami, Han-Dong Sun, Shun-Lin Li, Yoshihisa Takaishi and Yoshiki Kashiwada :
Studies on medicinal plants of Yunnan province: constituents of Gentiana rigescens,
Planta Medica, Vol.80, 785, Oxford, Mississipi, USA, Aug. 2014.

(出版サイトへのリンク): ● Publication site (DOI): 10.1055/s-0034-1382458
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1055/s-0034-1382458

(DOI: 10.1055/s-0034-1382458) Ishii Yasuyo, Kim Sang-Yong, Yoshihisa Takaishi and Yoshiki Kashiwada :
Hydroxycinnamoyl 1,2-dihydro¬furo[3,2-e]tryptamine derivatives from defatted safflower seeds.,
International Congress on Natural Products Research, New York, Jul. 2012. Kurimoto Shin-ichiro, Pu Jian-Xin, Sun Han-Dong, Yoshihisa Takaishi and Yoshiki Kashiwada :
Sesterterpenoids and diterpenoids from the aerial parts of Scutellaria coleifolia Levl,
International Congress on Natural Products Research, New York, Jul. 2012. Sasaki Hisako, Sato Hisayo, Yoshiki Kashiwada, Kazuyoshi Kawazoe, Kotarou Murakami, Hirofumi Shibata, Sun Han-Dong, Li Shun-Lin and Yoshihisa Takaishi :
Studies on the constituents of Cudrania tricuspidata,
International Congress on Natural Products Research, New York, Jul. 2012. Kim Sang-Yong, Yoshiki Kashiwada, Kazuyoshi Kawazoe, Kotarou Murakami, Sun Han-Dong, Li Shun-Lin and Yoshihisa Takaishi :
STUDIES ON THE CONSTITUENTS OF CHLORANTHUS SPICATUS (THUNB.) MAKINO,
2011 AMERICAN SOCIETY OF PHARMACOGNOSY ANNUAL MEETING, 74, San Diego, Aug. 2011. Sasaki Hisako, Yoshiki Kashiwada, Hirofumi Shibata and Yoshihisa Takaishi :
STUDIES ON THE CONSTITUENTS OF DESMODIUM CAUDATUM,
2011 AMERICAN SOCIETY OF PHARMACOGNOSY ANNUAL MEETING, San Diego, Aug. 2011. Omichi Yuka, Kurimoto Shin-ichiro, Yoshiki Kashiwada, Hirofumi Shibata, Miyake Yoshiyuki, Kirimoto Tsukasa and Yoshihisa Takaishi :
THE CONSTITUENTS OF THE FLOWER BUDS OF LONICERA JAPONICA AND THEIR ANTI-INFLUENZA ACTIVITIY,
2011 AMERICAN SOCIETY OF PHARMACOGNOSY ANNUAL MEETING, 66, San Diego, Aug. 2011. Yoshiki Kashiwada, Xiong Juan, Chen Chin-Ho, Qian Keduo, Morris-Natschke L. Susan, Lee Hsiung Kuo and Yoshihisa Takaishi :
CONJUGATES OF BEVIRIMAT WITH BETURIN DERIVATIVES AS ANTI-HIV AGENTS,
2011 AMERICAN SOCIETY OF PHARMACOGNOSY ANNUAL MEETING, 66, Aug. 2011. Kurimoto Shin-ichiro, Yoshiki Kashiwada, Lee Kuo-Hsiung and Yoshihisa Takaishi :
CHEMICAL STUDY ON DYSOXYLUM CUMINGIANUM (MELIACEAE),
2011 AMERICAN SOCIETY OF PHARMACOGNOSY ANNUAL MEETING, 58, San Diego, Jul. 2011. Daisuke Tsuji, T Koyama, Yoshiki Kashiwada, Yoshihisa Takaishi and Kouji Itou :
Lycorine induces differentiation from embryonic stem cells into PSA-NCAM-positive cells,
ICS2010, Chiba, Aug. 2010. Yoshihisa Takaishi, Yoshiki Kashiwada, Hashida Waka, Mikuchi Kousuke and Koichiro Tsuchiya :
FERULOYL MUCIC ACID DERIVATIVES AS SIRT1 STUMULATOR FROM CITRUS SUDACHI HORT. EX SHIRAI.,
50th Annual Meeting of the American Society of Pharmacognosy, Honolulu, Jun. 2009. Yoshiki Kashiwada, Xiong Juan, Kilgore R. Nicole, Wild T. Carl, Allaway P. Graham, Lee Kuo-Hsiung and Yoshihisa Takaishi :
3-O-ACYL BETULIN DERIVATIVE AND AZT CONJUGATE AS ANTI-HIV AGENTS.,
50th Annual Meeting of the American Society of Pharmacognosy, Honolulu, Jun. 2009. Xiong Juan, Taniguchi Masatoshi, Yoshiki Kashiwada, Yamagishi Takashi and Yoshihisa Takaishi :
AMIDE DERIVATIVES OF PAPYRIFERIC ACID AS MDR-REVERSING AGENTS.,
50th Annual Meeting of the American Society of Pharmacognosy, Honolulu, Jun. 2009. Kim Sang-Yong, Yoshiki Kashiwada, Kazuyoshi Kawazoe, Kotarou Murakami, Sun Han-Dong, Li Shun-Lin and Yoshihisa Takaishi :
STUDIES ON THE CONSTITUENTS OF CHLORANTHUS SPICATUS (THUNB.) MAKINO.,
50th Annual Meeting of the American Society of Pharmacognosy, Honolulu, Jun. 2009. Kurimoto Shin-ichiro, Suzuki Kyoko, Yoshiki Kashiwada, Okasaka Mamoru, Kodzhimatov K. Olimjon and Yoshihisa Takaishi :
STUDY ON MEDICINAL PLANTS OF UZBEKISTAN: CONSTITUENTS OF THE ROOTS OF FERULA VARIA (SCHRENK) TRAUTV.,
50th Annual Meeting of the American Society of Pharmacognosy., Honolulu, Jun. 2009. Sang-Yong Kim, Yoshiki Kashiwada, Yoshihisa Takaishi, Kazuyoshi Kawazoe, Kotarou Murakami and Shun-Lin Li :
Studies on the constituents of Chloranthus spicatus (Thumb.) Makino.,
7th Joint Meeting of AFERP, ASP, GA, PSE&SIF, 1059, Athens, Aug. 2008. Yoshiki Kashiwada, Masatoshi Taniguchi, Xiong Juan, Takashi Yamagishi and Yoshihisa Takaishi :
Triterpene derivatives and their reversing activity against multidrug resistant cancer cells.,
7th Joint Meeting of AFERP, ASP, GA, PSE&SIF, Athens, Aug. 2008. 中川雄太, 瀧澤伶奈, Yang Xue-Rong, Lu Feng-Lai, Yan Xiao-Jie, Li Dian-Peng, 柏田良樹, 田中直伸 :
中国広西壮族自治区の薬用植物に関する研究(6)-Huypericum sampsonii由来の新規プレニル化アシルフロログルシノール誘導体の構造-,
日本薬学会第144年会, 2024年3月. 瀧澤伶奈, 金尚永, 高上馬希重, 柏田良樹, 田中直伸 :
オトギリソウ科植物の成分に関する研究(58)-ミズオトギリ地上部由来の新規benzophenone rhamnosideの構造-,
日本薬学会第144年会, 2024年3月. 瀧澤伶奈, 金尚永, 高上馬希重, 柏田良樹, 田中直伸 :
オトギリソウ科植物の成分に関する研究(58)-ミズオトギリ由来の新規プレニル化ベンゾイルフロログルシノール誘導体の構造-,
第62回日本薬学会中国四国支部学術大会, 198, 2023年10月. 奥村俊輔, 辻大輔, 赤木玲子, 柏田良樹, 田中直伸 :
ドウダンツツジ由来の新規アシル化ヘミテルペン配糖体の構造,
日本生薬学会第69回年会, 288, 2023年9月. 瀧澤伶奈, 辻大輔, 金尚永, 高上馬希重, 赤木玲子, 柏田良樹, 田中直伸 :
オトギリソウ科植物の成分に関する研究(57)-ミズオトギリ由来の新規プレニル化ベンゾイルフロログルシノール誘導体の構造と生物活性-,
日本生薬学会第69回年会, 286, 2023年9月. 髙橋朔良, 後藤佑斗, 政田さやか, 辻大輔, 赤木玲子, 柏田良樹, 田中直伸 :
紅花から単離した含窒素キノカルコンC-配糖体の構造と生物活性,
日本薬学会第143年会, 2023年3月. 瀧澤伶奈, 下元悠聖, 今林潔, 辻大輔, 伊藤孝司, 柏田良樹, 田中直伸 :
オトギリソウ科植物の成分に関する研究(56)-Hypericum sp.花部由来のプレニル化アシルフロログルシノールの構造と生物活性-,
日本薬学会第143年会, 2023年3月. 永田千明, Sang-Yong Kim, 高上馬希重, 柏田良樹, 田中直伸 :
オトギリソウ科Hypericum属植物に関する研究(55)―Hypericum erectum地上部由来のビスントラキノン配糖体の構造ー,
第61回日本薬学会中国四国支部学術大会, 202, 2022年11月. 柴田一光, 永田千明, 田崎友亮, 辻大輔, 伊藤孝司, Xue-Rong Yang, Feng-Lai Lu, Xiao-Jie Yan, Dian-Peng Li, 柏田良樹, 田中直伸 :
中国広西壮族自治区の薬用植物に関する研究(5),
第61回日本薬学会中国四国支部学術大会, 202, 2022年11月. 高橋朔良, 瀧澤伶奈, 辻大輔, 伊藤孝司, 冨永辰也, 柏田良樹, 田中直伸 :
神田茶「茶汁」に含まれるカテキン代謝物の構造と生物活性,
第9回食品薬学シンポジウム, 118-120, 2022年10月. 吉野悠希, 辻大輔, 伊藤孝司, 柏田良樹, 田中直伸 :
セリ科Ferula communis根の成分研究(7),
日本生薬学会第68回年会, 308, 2022年9月. 髙橋朔良, 後藤佑斗, 政田さやか, 柏田良樹, 田中直伸 :
紅花由来の含窒素キノカルコンC-配糖体tinctormineの構造の再検討,
日本生薬学会第68回年会, 307, 2022年9月. 高橋朔良, 田中直伸, 柏田良樹 :
神田茶「茶汁」に関する科学的研究(5)-神田茶「茶汁」から単離したカテキン代謝物の構造-,
日本薬学会第142年会, 2022年3月. 位上健太郎, 伊藤久富, 宮崎寿次, 田中直伸, 柏田良樹 :
発酵霊芝のI型アレルギーに対する抑制効果とその関与成分の探索,
日本薬学会第142年会, 2022年3月. 柴田一光, 永田千明, 田崎友亮, 田中直伸, Yang XueRong, Feng-Lai Lu, Xiao-Jie Yan, Dian-Peng Li, 柏田良樹 :
中国広西壮族自治区の薬用植物に関する研究(3)-Canscora lucidissima地上部の成分研究-,
日本薬学会第142年会, 2022年3月. 柴田一光, 永田千明, 田崎友亮, 田中直伸, Xue-Rong Yang, Feng-Lai Lu, Xiao-Jie Yan, Dian-Peng Li, 柏田良樹 :
中国広西壮族自治区の薬用植物に関する研究(3),
第60回日本薬学会中国四国支部学術大会, 118, 2021年10月. 高橋朔良, 田中直伸, 辻大輔, 伊藤孝司, 柏田良樹 :
神田茶「茶汁」に関する科学的研究(4),
第60回日本薬学会中国四国支部学術大会, 118, 2021年10月. 高橋朔良, 田中直伸, 辻大輔, 伊藤孝司, 柏田良樹 :
神田茶「茶汁」に関する科学的研究(3),
日本生薬学会第67回年会, 246, 2021年9月. 田中直伸, 高橋朔良, 梶原聖太, 丹羽莞慈, 辻大輔, 伊藤孝司, 柏田良樹 :
ウズベキスタン産薬用植物Perovskia scrophulariifoliaより単離した新規ノルジテルペンperovsfolin A-Dの構造と生物活性,
第63回天然有機化合物討論会, 475-480, 2021年9月. 嵯峨山和美, 田中直伸, 福元隆俊, 山下菊治, 柏田良樹 :
「チャーガ」由来の発毛・育毛活性成分の探索研究(2),
第46回日本香粧品学会, 24, 2021年6月. 丹羽莞慈, 田中直伸, 柏田良樹 :
桂皮成分に関する研究(4)—桂皮由来の新規ジテルペンの構造–,
日本薬学会第141年会, 2021年3月. 髙橋朔良, 田中直伸, 柏田良樹 :
神田茶「茶汁」に関する科学的研究(2)-神田茶「茶汁」から単離した化合物の構造ー,
日本薬学会第141年会, 2021年3月. 下元悠聖, 田中直伸, 柏田良樹 :
オトギリソウ科Hypericum属植物に関する研究(52-エゾオトギリ地上部の成分研究―,
第59回日本薬学会中国四国支部学術大会, 165, 2020年12月. 髙橋朔良, 田中直伸, 柏田良樹 :
神田茶茶汁に関する科学的研究,
第59回日本薬学会中国四国支部学術大会, 164, 2020年12月. 丹羽莞慈, 田中直伸, 柏田良樹 :
桂皮成分に関する研究―桂皮由来の新規ジテルペンの構造―,
第59回日本薬学会中国四国支部学術大会, 165, 2020年12月. 丹羽莞慈, 田中直伸, 柏田良樹 :
桂皮成分に関する研究―桂皮から単離した新規ジテルペンの構造―,
第62回天然有機化合物討論会, 649-654, 2020年9月. 丹羽莞慈, 田中直伸, 柏田良樹 :
桂皮成分に関する研究ー桂皮ジテルペンの化学的再検討ー,
日本薬学会第140年会, 2020年3月. 賽旦夏阿木提, 田中直伸, 柏田良樹 :
Studies on unutilized parts of medicinal plants: Secocycloartane triterpenes from the roots of Scisandra chinensis,
日本薬学会第140年会, 2020年3月. 田中直伸, 梶原聖太, 丹羽莞慈, Mamadalieva Nilufar, 柏田良樹 :
ウズベキスタン産薬用植物に関する研究(38) ーシソ科植物Perovskia scrophulariifolia由来の新規ノルアビエタン型ジテルペンの構造ー,
日本薬学会第140年会, 2020年3月. 梶原聖太, 田中直伸, Nilufar Mamadalieva, 柏田良樹 :
ウズベキスタン産薬用植物に関する研究(37)-Perovskia scrophulariifoliaの成分研究(1)-,
第58回日本薬学会中国四国支部学術大会, 130, 2019年11月. 丹羽莞慈, 田中直伸, 多田納豊, 八木秀樹, Chen Chin-Ho, Lee Kuo-Hsiung, 柏田良樹 :
オトギリソウ科Hypericum属植物に関する研究(51)-Hypericum ascyron根由来のメロテルペンの構造と生物活性-,
第63回香料・テルペンおよび精油化学に関する討論会, 96-99, 2019年9月. 羊学荣, 田中直伸, Lu Feng-Lai, Yan Xiao-Jie, Li Dian-Peng, 柏田良樹 :
Studies on traditional medicines in Guangxi (2): New limonoids from the aerial parts of Munronia pinnata (Meliaceae) (2),
日本生薬学会第66回年会, 247, 2019年9月. 吉野悠希, 田中直伸, 柏田良樹 :
セリ科植物Ferula communis根の成分研究(4),
日本生薬学会第66回年会, 246, 2019年9月. 楠本嵩志, 堂前純子, 田中直伸, 柏田良樹, 辻大輔, 伊藤孝司, 石田竜弘, 奥平桂一郎 :
天然物による膜トランスポーターABCA7の発現増強機構の解析,
第92回日本生化学会大会, 2019年9月. 羊学荣, 田中直伸, Lu Feng-Lai, Li Dian-Peng, 柏田良樹 :
Studies on traditional herbal medicines in Guangxi (1): New limonoids from the aerial parts of Munronia pinnata (Meliaceae),
日本薬学会第139年会, 203, 2019年3月. 任翌, 田中直伸, 川添和義, 村上光太郎, Tsogtbaatar Ariuntuya, Bunddulam Perleidulam, Damdinjav Davaadagva, 柏田良樹 :
モンゴル民族伝統薬物に関する研究(12)-オオバコ科植物Linaria buriatica地上部の成分研究(2)-,
日本薬学会第139年会, 202, 2019年3月. 吉野悠希, 田中直伸, 柏田良樹 :
セリ科植物Ferula communis根の成分研究(3),
日本薬学会第139年会, 202, 2019年3月. 楠本嵩志, 堂前純子, 田中直伸, 柏田良樹, 辻大輔, 伊藤孝司, 石田竜弘, 奥平桂一郎 :
膜タンパク質ABCA7を増加させる新規天然物,
日本薬学会第139年会, 2019年3月. 吉野悠希, 田中直伸, 柏田良樹 :
セリ科植物Ferula communis根の成分研究(2),
第57回日本薬学会中国四国支部学術大会, 153, 2018年11月. Lee Sanghoon, 田中直伸, 小林淳一, 柏田良樹 :
Boromopyrrole alkaloids from an Okinawan marine sponge Agelas sp.,
第57回日本薬学会中国四国支部学術大会, 153, 2018年11月. 丹羽莞慈, 田中直伸, 柏田良樹 :
オトギリソウ科Hypericum属植物に関する研究(50)-トモエソウ根から単離したフロログルシノール誘導体の構造-,
第57回日本薬学会中国四国支部学術大会, 154, 2018年11月. 丹羽莞慈, 田中直伸, 柏田良樹 :
オトギリソウ科Hypericum属植物に関する研究(49)-H. ascyron(トモエソウ)根の成分研究-,
第22回天然薬物の開発と応用シンポジウム, 135-137, 2018年10月. 丹羽莞慈, 田中直伸, 柏田良樹 :
オトギリソウ科Hypericum属植物に関する研究(47)-トモエソウ由来の新規ジベンゾジオキサン誘導体hyperdioxanesA-Cの構造-,
第60回天然有機化合物討論会, 427-432, 2018年9月. 羊学荣, 田中直伸, Lu Feng-Lai, Yan Xiao-Jie, Li Dian-Peng, 柏田良樹 :
Studies on traditional medicines in Guangxi (2): New limonoids from the aerial parts of Munronia pinnata (Meliaceae) (2),
日本生薬学会第66回年会, 247, 2018年9月. 吉野悠希, 田中直伸, 柏田良樹 :
セリ科植物Ferula communis根の成分研究,
日本生薬学会第66回年会, 246, 2018年9月. 丹羽莞慈, 田中直伸, 柏田良樹 :
オトギリソウ科Hypericum属植物に関する研究(48)-トモエソウ根由来のphloroglucinol誘導体の構造-,
日本生薬学会第65回年会, 133, 2018年9月. 任翌, 田中直伸, 川添和義, 村上光太郎, Tsogtbaatar Ariuntuya, Bunddulam Perleidulam, Davaadagva Damjinjv, 柏田良樹 :
モンゴル民族伝統薬物に関する研究(11)-ゴマノハグサ科植物Linaria buriatica地上部の成分研究-,
日本生薬学会第65回年会, 134, 2018年9月. 田中藍, 金尚永, 羊学荣, 田中直伸, 李典鵬, 柏田良樹, 高上馬希重 :
センリョウ科植物Chloranthus elatiorの成分研究,
日本薬学会北海道支部第145回例会, 50, 2018年5月. 金尚永, 長嶋絋紗子, 高上馬希重, 田中直伸, 柏田良樹, 小林淳一 :
ヒトリシズカ(Chloranthus japonicus)より単離したHitorin CとDの構造,
日本生薬学会北海道支部第42回例会, 77, 2018年5月. 山田健太, 田中直伸, 川添和義, 村上光太郎, Damdinjav Davaadagva, Dorjval Enkhjargal, 柏田良樹 :
モンゴル民族伝統薬物に関する研究(10)-シソ科植物Lophanthus chinensis地上部の成分研究(2)-,
日本薬学会第138年会, 205, 2018年3月. 吉野悠希, 田中直伸, 柏田良樹 :
セリ科植物Ferula communis根の成分研究,
日本薬学会第138年会, 203, 2018年3月. 嵯峨山和美, 丹羽莞慈, 田中直伸, 福本隆俊, 柏田良樹 :
モンゴル民族伝統薬物に関する研究(9)-「チャーガ」子実体由来の発毛・育毛活性成分の探索研究-,
日本薬学会第138年会, 202, 2018年3月. 矢野優希, 田中直伸, 柏田良樹 :
オトギリソウ科Hypericum属植物に関する研究(46)-キンシバイより単離した新規ベンゾフェノン誘導体hypatulin Cの構造-,
日本薬学会第138年会, 95, 2018年3月. 楠本嵩志, 市野晨人, 西辻和親, 坂下直実, 堂前純子, 田中直伸, 柏田良樹, 石田竜弘, 奥平桂一郎 :
膜タンパク質ABCA7の発現を調節する化合物の探索,
日本薬学会第138年会, 2018年3月. 丹羽莞慈, 賈玉鈺, 田中直伸, 柏田良樹 :
ギンバイカ由来の新規フロログルシノール誘導体myrtcommunin A-Hの構造,
第7回食品薬学シンポジウム, 116-118, 2017年10月. Lee Sanghoon, 田中直伸, 小林淳一, 柏田良樹 :
New diterpene alkaloids and bromopyrrole alkaloids from marine sponges Agelas spp.,
第56回日本薬学会中国四国支部学術大会, 177, 2017年10月. 山田健太, 田中直伸, 川添和義, 村上光太郎, Davaadagva Damdinjav, Enkhjargal Dorjval, 柏田良樹 :
モンゴル民族伝統薬物に関する研究(8)ーシソ科植物Lophanthus chinensis地上部の成分研究ー,
第56回日本薬学会中国四国支部学術大会, 179, 2017年10月. 洲山佳寛, 東野勇佑, 田中直伸, 川添和義, 村上光太郎, 李順林, 孫漢董, 柏田良樹 :
アカネ科植物Rubia yunnanensis根由来の新規ナフトキノン誘導体の構造,
第59回天然有機化合物討論会, 561-566, 2017年9月. 金尚永, 森岡諒, 長嶋紘紗子, 田中直伸, 柏田良樹, 小林淳一, 高上馬希重 :
ヒトリシズカ(Chloranthus japonicus)地上部より単離した新規C25テルペノイドHitorin E-H,
第59回天然有機化合物討論会, 525-529, 2017年9月. 位上健太郎, 下条洋輔, 野渕翠, 小坂邦男, 宮崎寿次, 伊藤久富, 田中直伸, 柏田良樹 :
発酵霊芝の高脂肪食摂取マウスに及ぼす影響,
日本生薬学会第64回年会, 230, 2017年9月. 東野勇佑, 洲山佳寛, 田中直伸, 川添和義, 村上光太郎, 李順林, 孫漢董, 柏田良樹 :
雲南省産伝統薬物に関する研究(28)–アカネ科植物Rubia yunnanensis根の成分研究–,
日本生薬学会第64回年会, 90, 2017年9月. Sanghoon Lee, 田中直伸, Jun'ichi Kobayashi, 柏田良樹 :
New diterpene alkaloids from an Okinawan marine sponge Agelas sp.,
日本生薬学会第64回年会, 180, 2017年9月. 森岡諒, 金尚永, 長嶋紘紗子, 田中直伸, 柏田良樹, 小林淳一, 高上馬希重 :
センリョウ科Chloranthus属植物の成分研究(14)–ヒトリシズカ地上部より単離した新規C25テルペノイドHitorin G及びHの構造–,
日本生薬学会第64回年会, 127, 2017年9月. 森岡諒, 金尚永, 長嶋紘紗子, 田中直伸, 柏田良樹, 高石喜久, 小林淳一, 高上馬希重 :
ヒトリシズカ(Chloranthus japonicus)地上部より単離した新規C25テルペノイドの構造,
日本生薬学会北海道支部第41回例会, 2017年5月. Licht Miyamoto, Aihara Haruna, Xu Wenting, Jin Meina, Tomida Yosuke, Yamaoka Tomomi, Tanaka Naonobu, Yasumasa Ikeda, Toshiaki Tamaki, Yoshiki Kashiwada and Koichiro Tsuchiya :
A limonene-derivative purified from Sudachi peel upregulates sirt1 and improves lipid /glucose metabolism in HFD-fed mice.,
第60回日本糖尿病学会, May 2017. 丹羽莞慈, 田中直伸, 柏田良樹 :
オトギリソウ科Hypericum属植物に関する研究(45)—H. pseudohenryi地上部由来の新規phenylketide-short ketide複合体，pseudoherin A–Eの構造—,
日本薬学会第137年会, 2017年3月. 森岡諒, 金尚永, 長嶋紘紗子, 田中直伸, 高石喜久, 柏田良樹, 小林淳一, 高上馬希重 :
北海道産ヒトリシズカ(Chloranthus japonicus)地上部の成分研究,
日本薬学会第137年会, 2017年3月. 賈玉鈺, 田中直伸, 柏田良樹 :
フトモモ科植物ギンバイカ葉由来の新規フロログルシノール-フラボノイド複合体の構造,
日本薬学会第137年会, 2017年3月. 東野勇佑, 田中直伸, Ahmed Ali Fakhruddin, 柏田良樹 :
バングラデシュ産薬用植物に関する研究(13)-テリハボク科植物Mesua ferrea葉由来のプレニル化アシルフロログルシノール誘導体と4-フェニルクマリンの構造-,
日本薬学会第137年会, 2017年3月. 福田明穂, 田中直伸, Ahmed Ali Fakhruddin, 柏田良樹 :
バングラデシュ産薬用植物に関する研究(12)-センダン科植物Aphanamixis polystachya樹皮由来の新規鎖状テルペノイドの構造-,
日本薬学会第137年会, 2017年3月. 丹羽莞慈, 田中直伸, 柏田良樹 :
オトギリソウ科Hypericum属植物に関する研究(44)ーH. pseudohenryi地上部の成分探索ー,
第55回日本薬学会中国四国支部学術大会, 217, 2016年11月. 東野勇佑, 田中直伸, Ahmed Ali Fakhruddin, 柏田良樹 :
バングラデシュ産薬用植物に関する研究(11)ーテリハボク科植物Mesua ferrea葉の成分研究ー,
第55回日本薬学会中国四国支部学術大会, 218, 2016年11月. 東野勇佑, 田中直伸, 多田納豊, Ahmed Ali Fakhruddin, 柏田良樹 :
バングラデシュ産薬用植物に関する研究(10)ーテリハボク科植物Mesua ferrea葉由来の4-フェニルクマリン類の構造と生物活性(2)ー,
第21回天然薬物の開発と応用シンポジウム, 139-141, 2016年10月. 田中直伸, 浅井美貴, 草間大志, 柏田良樹, 小林淳一 :
沖縄産Plakortis属海綿から単離した新規オキシリピンmanzamenone OおよびPの構造と生物活性,
第21回天然薬物の開発と応用シンポジウム, 136-138, 2016年10月. 位上健太郎, 下条洋輔, 野渕翠, 小坂邦男, 宮崎寿次, 伊藤久富, 柏田良樹 :
血管内皮細胞の炎症に対する発酵霊芝の影響,
日本生薬学会第63回年会, 148, 2016年9月. 中谷愛, 田中直伸, Fakhruddin Ali Ahmed, Chin-Ho Chen, Kuo-Hsiung Lee, 柏田良樹 :
バングラデシュ産薬用植物に関する研究(9)–トウダイグサ科植物Sapoium indicum果実の成分研究(3)–,
日本生薬学会第63回年会, 297, 2016年9月. 森越祥太, 金尚永, 坂井大地, 増子ひとみ, 田中直伸, 柏田良樹, 高石喜久, 小林淳一, 高上馬希重 :
センリョウ科植物フタリシズカ(Chloranthus serratus)地上部の成分研究,
日本生薬学会第63回年会, 295, 2016年9月. 金尚永, 長嶋紘紗子, 田中直伸, 柏田良樹, 高石喜久, 小林淳一, 高上馬希重 :
センリョウ科植物ヒトリシズカ(Chloranthus japonicus)地上部の成分研究,
日本生薬学会第63回年会, 294, 2016年9月. 東野勇佑, 田中直伸, Ahmed Ali Fakhruddin, 柏田良樹 :
バングラデシュ産薬用植物に関する研究(8)–テリハボク科植物Mesua ferrea葉の成分研究–,
日本生薬学会第63回年会, 86, 2016年9月. 岩屋愛美, 田中直伸, 柏田良樹 :
ジンチョウゲ科植物ミツマタEdgeworthia chrysantha樹皮の成分研究,
日本生薬学会第63回年会, 85, 2016年9月. 矢野優希, 田中直伸, 多田納豊, 柏田良樹 :
オトギリソウ科Hypericum属植物に関する研究(43)–キンシバイより単離した新規ベンゾフェノン誘導体hypatulin AおよびBの構造–,
日本生薬学会第63回年会, 84, 2016年9月. 金尚永, 長嶋紘紗子, 田中直伸, 高石喜久, 柏田良樹, 小林淳一, 高上馬希重 :
ヒトリシズカ(Chloranthus japonicus)地上部より単離したC25テルペノイドの構造,
第58回天然有機化合物討論会, 445-450, 2016年9月. 田中直伸, 矢野優希, 大屋厚, 金尚永, 高上馬希重, 小林淳一, 柏田良樹 :
オトギリソウ科Hypericum属およびTriadenum属植物から単離した新規ベンゾフェノン誘導体の構造,
第58回天然有機化合物討論会, 439-444, 2016年9月. 頼田和子, 黒澤すみれ, 吉田結理, 大髙章, 柏田良樹, 佐野茂樹, 南川典昭, 福井清 :
ヒトD-アミノ酸酸化酵素のエフェクター探索と構造活性相関,
日本ビタミン学会第68回大会, 2016年6月. 柏田良樹 :
徳島大学薬学部薬用植物園における教育・研究及び情報発信に関する取組み,
日本東洋医学雑誌(第67回日本東洋医学会学術総会講演要旨集), Vol.67, 125, 2016年6月. 丹羽莞慈, 田中直伸, 柏田良樹 :
オトギリソウ科Hypericum属植物に関する研究(42)–H. pseudohenryi地上部の成分探索–,
日本薬学会第136年会, Vol.2, 113, 2016年3月. 金尚永, 長嶋絋紗子, 田中直伸, 柏田良樹, 高石喜久, 小林淳一, 高上馬希重 :
センリョウ科植物ヒトリシズカ (Chloranthus japonicus) 地上部の成分研究,
日本薬学会第136年会, Vol.2, 226, 2016年3月. 田口響, 栗本慎一郎, 佐々木有, 田中直伸, 柏田良樹, 中村隆典 :
メグスリノキ(Acer nikoense)樹皮の成分研究,
日本薬学会第136年会, Vol.2, 224, 2016年3月. 洲山佳寛, 田中直伸, 川添和義, 村上光太郎, 孫漢董, 李順林, 柏田良樹 :
雲南省産伝統薬物に関する研究(27)–Gentiana rigescensの成分研究–,
日本薬学会第136年会, Vol.2, 61, 2016年3月. 宮本理人, 粟飯原遥菜, 許文婷, 靳美娜, 冨田洋輔, 山岡朋美, 田中直伸, 池田康将, 玉置俊晃, 柏田良樹, 土屋浩一郎 :
スダチ果皮における抗メタボリックシンドローム作用を有する物質の同定,
日本薬学会第136年会(横浜), 2016年3月. Licht Miyamoto, Haruna Aihara, Wenting Xu, Meina Jin, Yosuke Tomida, Tomomi Yamaoka, Naonobu Tanaka, Yasumasa Ikeda, Toshiaki Tamaki, Yoshiki Kashiwada and Koichiro Tsuchiya :
Identification of an active compound on lipid metabolism from Sudachi peel,
薬理学会(パシフィコ), Mar. 2016. 宮本理人, 粟飯原遥菜, Xu Wenting, Jin Meina, 冨田洋輔, 山岡朋美, 田中直伸, 池田康将, 玉置俊晃, 柏田良樹, 土屋浩一郎 :
脂質低下作用を有するスダチ果皮由来化合物の薬理作用,
第89回日本薬理学会年会(神奈川), 2016年3月. 丹羽莞慈, 田中直伸, 柏田良樹 :
オトギリソウ科Hypericum属植物に関する研究(42)–Hypericum chinense葉の成分探索–,
第54回日本薬学会中国四国支部学術大会, 124, 2015年10月. 洲山佳寛, 田中直伸, 栗本慎一郎, 川添和義, 村上光太郎, 孫漢董, 李順林, 高石喜久, 柏田良樹 :
雲南省産伝統薬物に関する研究(26)–Gentiana rigescensの成分研究(6)–,
第54回日本薬学会中国四国支部学術大会, 124, 2015年10月. 中谷愛, 田中直伸, Ali Fakhruddin Ahamed, 柏田良樹 :
バングラディシュ産薬用植物に関する研究(7) –トウダイグサ科Sapium indicum果実の成分研究(2)–,
第54回日本薬学会中国四国支部学術大会, 123, 2015年10月. 呂爽欣, 田中直伸, 柏田良樹 :
Studies on the constituents of Hypericum plants (41): Prenylated acylphloroglucinols from the roots of Hypericum erectum,
日本生薬学会第62回年会, 90, 2015年9月. 丹羽莞慈, 田中直伸, 柏田良樹 :
オトギリソウ科Hypericum属植物に関する研究(40)–Hypericum chinense葉に含まれるメロテルペンの探索–,
日本生薬学会第62回年会, 89, 2015年9月. 坂井大地, 金尚永, 増子ひとみ, 田中直伸, 柏田良樹, 高石喜久, 小林淳一, 高上馬希重 :
センリョウ科植物フタリシズカ(Chloranthus serratus)地上部の成分研究,
日本生薬学会第62回年会, 134, 2015年9月. 長嶋絋紗子, 金尚永, 田中直伸, 川野辺弘子, 柏田良樹, 高石喜久, 小林淳一, 高上馬希重 :
センリョウ科植物ヒトリシズカ(Chloranthus japonicus)地上部の成分研究,
日本生薬学会第62回年会, 133, 2015年9月. 苅舎里紗, 田中直伸, 川添和義, 村上光太郎, Damdinjav Davaadagva, Enkhjargal Dorjval, 柏田良樹 :
モンゴル民族伝統薬物に関する研究(6)–キク科植物Saussurea pricei花部の成分研究–,
日本生薬学会第62回年会, 132, 2015年9月. 田中直伸, 辻依利, 柏田良樹, 小林淳一 :
オトギリソウ科植物エゾオトギリより単離したyezo'otogirin D-Iの構造,
日本生薬学会第62回年会, 119, 2015年9月. 丹羽莞慈, 田中直伸, 柏田良樹 :
オトギリソウ科Hypericum属植物に関する研究(39)–Hypericum chinense由来のメロテルペン–,
第57回天然有機化合物討論会, 333-337, 2015年9月. 頼田和子, 黒澤すみれ, 宍戸裕二, 佐野茂樹, 柏田良樹, 南川典昭, 福井清 :
ヒト由来D-アミノ酸酸化酵素のエフェクター探索のためのハイスループットクリーニングと構造機能相関,
第56回日本生化学会中国四国支部例会, 2015年5月. 長嶋絋紗子, 金尚永, 田中直伸, 柏田良樹, 高石喜久, 小林淳一, 高上馬希重 :
センリョウ科植物Chloranthus japonicusの成分について,
日本生薬学会北海道支部第39回例会, 68, 2015年5月. 坂井大地, 増子ひとみ, 金尚永, 田中直伸, 柏田良樹, 高石喜久, 小林淳一, 高上馬希重 :
センリョウ科植物Chloranthus serratusの成分について,
日本生薬学会北海道支部第39回例会, 68, 2015年5月. 呂爽欣, 田中直伸, 川添和義, 村上光太郎, Enkhjargal Dorival, Davaadagva Damdinjav, 柏田良樹 :
モンゴル民族伝統薬物に関する研究(6)–リンドウ科植物Gentianella acuta地上部の成分研究–,
日本薬学会第135年会, Vol.2, 129, 2015年3月. 金尚永, 田中直伸, 柏田良樹, 高石喜久, 小林淳一, 高上馬希重 :
センリョウ科植物ヒトリシズカ(Chloranthus japonicus)地上部の成分について,
日本薬学会第135年会, Vol.2, 228, 2015年3月. 上園望緒, 田中直伸, 川添和義, 村上光太郎, Dorival Enkhjargal, Damdinjav Davaadagva, 柏田良樹 :
モンゴル民族伝統薬物に関する研究(5)–ハマビシ科植物Peganum nigellastrumの成分研究–,
日本薬学会第135年会, Vol.2, 232, 2015年3月. 和田悠, Chin-Ho Chen, Kuo-Hsiung Lee, 田中直伸, 柏田良樹 :
抗HIV天然物に関する研究(27)–アミノ酸を含むリンカーによるベツリン酸誘導体とAZTの縮合体の合成と抗HIV活性–,
日本薬学会第135年会, Vol.2, 226, 2015年3月. 草間大志, 田中直伸, 柏田良樹, 小林淳一 :
沖縄産Agelas属海綿より単離した新規ブロモピロールアルカロイドの構造,
日本薬学会第135年会, Vol.2, 232, 2015年3月. 松澤和樹, 田中直伸, Ahmed Ali Fakhuruddin, 柏田良樹 :
バングラディシュ産薬用植物に関する研究(5)–センダン科植物Xylocarpus mekogensis樹皮の成分研究–,
日本薬学会第135年会, Vol.2, 87, 2015年3月. 松澤和樹, 田中直伸, 栗本慎一郎, Ahmed Fakhruddin Ali, 柏田良樹 :
バングラディシュ産植物の成分研究(4) -センダン科植物Xylocarpus mekongensis樹皮の成分研究-,
第53回日本薬学会中国四国支部学術大会, 158, 2014年11月. 洲山佳寛, 田中直伸, 栗本慎一郎, 川添和義, 村上光太郎, 孫漢董, 李順林, 高石喜久, 柏田良樹 :
雲南省伝統薬物に関する研究(25) -Gentiana rigescensの成分研究(5)-,
第53回日本薬学会中国四国支部学術大会, 157, 2014年11月. 佐藤寿世, 田中直伸, 敷島康普, 酒巻康明, 柏田良樹 :
徳島県産ハスNelumbo nucifera可食部の成分研究,
第53回日本薬学会中国四国支部学術大会, 156, 2014年11月. 草間大志, 田中直伸, 柏田良樹, 小林淳一 :
沖縄産Agelas属海綿より単離した新規ブロモピロールアルカロイドAgelamadins C-Eの構造,
第53回日本薬学会中国四国支部学術大会, 155, 2014年11月. 草間大志, 田中直伸, 柏田良樹, 小林淳一 :
沖縄産Agelas属海綿から単離した新規ブロモピロールアルカロイドの構造,
第56回天然有機化合物討論会, 235-240, 2014年10月. 栗本慎一郎, 柏田良樹, 高石喜久, 普建新, 孫漢董, 中村隆典 :
シソ科植物Scutellaria coleifoliaのジテルペノイド成分,
第56回天然有機化合物討論会, 291-296, 2014年10月. 武方みなみ, 洲山佳寛, 田中直伸, 栗本慎一郎, 柏田良樹 :
中国ならびにモンゴル産Gentiana属植物の成分研究,
第56回天然有機化合物討論会, 357-362, 2014年10月. 金尚永, 田中直伸, 柏田良樹, 高石喜久, 小林淳一, 前田桂, 高上馬希重 :
センリョウ科植物ヒトリシズカ(Chloranthus japonicus)の成分について,
日本生薬学会第61回年会, 143, 2014年9月. 金尚永, 田中直伸, 柏田良樹, 高石喜久, 小林淳一, 高上馬希重 :
センリョウ科植物Chloranthus japonicusの成分について,
日本生薬学会北海道支部第38回例会, 68, 2014年5月. 武方みなみ, 栗本慎一郎, 高石喜久, 川添和義, 村上光太郎, Dorjval Enkhjargal, Damdinjav Davaadagva, 柏田良樹 :
モンゴル民族伝統薬物に関する研究(4)-Gentiana algida地上部の成分研究(1)-,
日本薬学会第134年会, Vol.2, 163, 2014年3月. 小早川夏樹, 栗本慎一郎, 高石喜久, 川添和義, 村上光太郎, Dorjval Enkhjargal, Damdinjav Davaadagva, 柏田良樹 :
モンゴル民族伝統薬物に関する研究(3)-Sanguisorba officinalis花部の成分研究(2)-,
日本薬学会第134年会, Vol.2, 163, 2014年3月. 市川沙季, 栗本慎一郎, 川添和義, 村上光太郎, 孫漢董, 李順林, 高石喜久, 柏田良樹 :
雲南省産伝統薬物に関する研究(25) –Potentilla freyniana地上部の成分研究-,
日本薬学会第134年会, Vol.2, 163, 2014年3月. 洲山佳寛, 栗本慎一郎, 川添和義, 村上光太郎, 孫漢董, 李順林, 高石喜久, 柏田良樹 :
雲南省産伝統薬物に関する研究(24) –Gentiana rigescensの成分研究 (4)-,
日本薬学会第134年会, Vol.2, 163, 2014年3月. 栗本慎一郎, 普建新, 孫漢董, 高石喜久, 柏田良樹 :
シソ科植物Scutellaria coleifolia地上部の成分研究(6),
日本薬学会第134年会, Vol.2, 65, 2014年3月. 柏田良樹 :
最近の生薬をめぐる動向と天然物化学的視点からのアプローチ,
第42回中四国支部総会, 2013年11月. 北山美香, 水口博之, 北村嘉章, 藤井達也, 関田泰子, 久保宣明, 久保伸夫, 柏田良樹, 福井裕行, 武田憲昭 :
HeLa細胞におけるナローバンドUVBのヒスタミンH1受容体遺伝子発現への影響,
第124回日本薬理学会近畿部会, 2013年11月. 栗本慎一郎, 普建新, 孫漢董, 高石喜久, 柏田良樹 :
シソ科植物Scutellaria coleifolia地上部の成分研究(5),
第52回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, 197, 2013年10月. 市川沙季, 栗本慎一郎, 川添和義, 村上光太郎, 孫漢董, 李順林, 高石喜久, 柏田良樹 :
雲南省産伝統薬物に関する研究(23) –Potentilla freyniana地上部の成分研究(1)-,
第52回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, 197, 2013年10月. 小笠紗也加, 川添和義, 村上光太郎, Dorjval Enkhjargal, Damdinjav Davaadagva, 高石喜久, 柏田良樹 :
モンゴル民族伝統薬物に関する研究(2)-Paeonia anomala根の成分研究(1),
第52回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, 196, 2013年10月. 橋本敏弘, 吉川和子, 谷沙希子, 山下智子, 井関賀奈子, 山本博文, 今川洋, 柏田良樹, 高石喜久, 馬場正樹, 岡田嘉仁, 河野幸子 :
シンビジウムグレートフラワー・マリーローランサンの葉に含まれる新規トリテルペン,
第57回香料・テルペンおよび精油化学に関する討論会, 2013年10月. 中野扶佐子, 栗本慎一郎, 川添和義, 村上光太郎, 孫漢董, 李順林, 高石喜久, 宮本理人, 土屋浩一郎, 柏田良樹 :
キク科植物Saussurea lanicepsの成分研究,
第55回天然有機化合物討論会, 2013年9月. 金尚永, 柏田良樹, 高石喜久, 川添和義, 村上光太郎, 孫漢董, 李順林, 高上馬希重 :
センリョウ科Chloranthus spicatus根の成分研究,
日本生薬学会第60回年会, 280, 2013年9月. 佐々木久子, 柴田洋文, 今林潔, 高石喜久, 柏田良樹 :
ミソナオシDesmodium caudatumの成分研究(8)–植物和名の由来に関する科学的検討-,
日本生薬学会第60回年会, 243, 2013年9月. 中野扶佐子, 栗本慎一郎, 川添和義, 村上光太郎, 孫漢董, 李順林, 高石喜久, 柏田良樹 :
雲南省産伝統薬物に関する研究(20) –Saussurea lanicepsの成分研究 (2)-,
日本生薬学会第60回年会, 195, 2013年9月. 洲山佳寛, 栗本慎一郎, 川添和義, 村上光太郎, 孫漢董, 李順林, 高石喜久, 柏田良樹 :
雲南省産伝統薬物に関する研究(21) –Gentiana rigescensの成分研究 (3)-,
日本生薬学会第60回年会, 196, 2013年9月. 栗本慎一郎, 普建新, 孫漢董, 高石喜久, 柏田良樹 :
シソ科植物Scutellaria coleifolia地上部の成分研究(4),
日本生薬学会第60回年会, 78, 2013年9月. 中嶋宏之, 足立愛美, 桑原香織, 川島浩之, 長尾耕治郎, 柏田良樹, 赤路健一, 斎藤博幸 :
アミロイド-シス変異アポA-Iの線維形成と細胞増殖抑制作用,
日本薬学会第133年会, 2013年3月. 佐々木久子, 柏田良樹, 柴田洋文, 高石喜久 :
ミソナオシDesmodium caudatumの成分研究(7),
日本薬学会第133年会, 2013年3月. 吉川和子, 山下智子, 井関賀奈子, 山本博文, 今川博, 柏田良樹, 高石喜久, 馬場正樹, 岡田嘉仁, 河野幸子, 橋本敏弘 :
シンビジウムグレートフラワー・マリーローランサンの葉のNO酸性抑制活性成分(2),
日本薬学会第133年会, 2013年3月. 佐渡香織, 栗本慎一郎, 高石喜久, 吉川和子, 橋本敏弘, 河野道郎, 河野幸子, 柏田良樹 :
シンビジウムグレートフラワー・マリーローランサン葉の成分について(5),
日本薬学会第133年会, 2013年3月. 中野扶佐子, 川添和義, 村上光太郎, 孫漢董, 李順林, 高石喜久, 柏田良樹 :
雲南省産伝統薬物に関する研究(19)—Saussurea lanicepsの成分研究(1)—,
日本薬学会第133年会, 2013年3月. 洲山佳寛, 栗本慎一郎, 川添和義, 村上光太郎, 孫漢董, 李順林, 高石喜久, 柏田良樹 :
雲南省産伝統薬物に関する研究(18) —Gentiana rigescens根の成分研究(2)—,
日本薬学会第133年会, 2013年3月. 栗本慎一郎, 普建新, 孫漢董, 高石喜久, 柏田良樹 :
シソ科植物Scutellaria coleifolia地上部の成分研究(3),
日本薬学会第133年会, 2013年3月. 洲山佳寛, 栗本慎一郎, 川添和義, 村上光太郎, 孫漢董, 李順林, 高石喜久, 柏田良樹 :
雲南省産伝統薬物に関する研究(17) —Gentiana rigescens根の成分研究(1)—,
日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, 2012年11月. 佐々木久子, 柏田良樹, 柴田洋文, 高石喜久 :
ミソナオシDesmodium caudatumの成分研究(6),
日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, 2012年11月. 佐渡香織, 栗本慎一郎, 高石喜久, 吉川和子, 橋本敏弘, 河野道郎, 河野幸子, 柏田良樹 :
Cymbidium Great Flower葉部の成分研究,
日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, 2012年11月. 小早川夏樹, 栗本慎一郎, 高石喜久, 川添和義, 村上光太郎, Dorjval Enkhjaragal, Damdinjv Davaadagva, 柏田良樹 :
モンゴル民族伝統薬物に関する研究(1) —Sanguisorba officinalis花部の成分研究(1) —,
日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, 2012年11月. 中野扶佐子, 高石喜久, 位上健太郎, 下条洋輔, 宮﨑寿次, 柏田良樹 :
発酵オタネ人参のアセトアミノフェン肝障害抑制成分の探索,
日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, 2012年11月. 栗本慎一郎, 普建新, 孫漢董, 高石喜久, 柏田良樹 :
シソ科植物Scutellaria coleifolia地上部の成分研究,
第54回天然有機化合物討論会, 2012年9月. 石井康世, 中野扶佐子, 高石喜久, 柏田良樹 :
ベニバナ(Carthamus tinctorius)脱脂種子に含まれる機能性成分の探索研究(4),
日本生薬学会第59回年会, 2012年9月. 金子礼, 柏田良樹, 高石喜久, 川添和義, 村上光太郎, 孫漢董, 李順林 :
雲南省伝統薬物に関する研究(16)—Kadsura interiaの成分について(2)—,
日本生薬学会第59回年会, 2012年9月. 栗本慎一郎, 普建新, 孫漢董, 高石喜久, 柏田良樹 :
シソ科植物Scutellaria coleifolia地上部の成分研究(1),
日本生薬学会第59回年会, 2012年9月. 福井裕行, 水口博之, 北村嘉章, 柏田良樹, 根本尚夫, 武田憲昭 :
抗ヒスタミン薬のアレルギー疾患症状改善に関する薬理機構,
第63回日本薬理学会北部会, 2012年9月. 石井康世, 柏田良樹, 高石喜久 :
ベニバナ脱脂種子の成分研究(3),
日本薬学会第132年会, No.2, 119, 2012年3月. 栗本慎一郎, 柏田良樹, 高石喜久 :
バングラデシュ産薬用植物に関する研究(3)-Azadirachta indicaの成分研究(2)-,
日本薬学会第132年会, No.2, 118, 2012年3月. 位上健太郎, 下条洋輔, 下条洋輔, 宮崎寿次, 中野扶佐子, 柏田良樹, 高石喜久 :
発酵オタネ人参のアセトアミノフェン肝障害抑制メカニズムの解明と有効成分の探索,
日本薬学会第132年会, No.2, 245, 2012年3月. 柏田良樹, JIN Meina, 柴山恵美子, 和田悠, 石澤啓介, 宮本理人, 土屋浩一郎, 井端和郎 :
スダチ(Citrus sudachi)果皮の有効利用に関する研究 (5) ―3-O-Feruloyl aldaric acid 1,4-lactone methyl esterの立体構造について―,
日本薬学会第132年会, No.2, 189, 2012年3月. 佐々木久子, 佐藤寿代, 柏田良樹, 川添和義, 村上光太郎, 柴田洋文, 孫漢董, 李順林, 高石喜久 :
雲南省産伝統薬物に関する研究(18)-Cudrania tricuspidataの成分研究-,
日本薬学会第132年会, No.2, 107, 2012年3月. 成相祐希, Hiroyuki Mizuguchi, 永井浩章, 金山知代, 加藤周平, Yoshiyuki Yoshimura, Yoshiki Kashiwada, Hisao Nemoto, Yoshihisa Takaishi, Noriaki Takeda and Hiroyuki Fukui :
Identification of the target molecule of the new anti-allergic compound, maackiain from Kujin,
第85回日本薬理学会年会, Mar. 2012. 石井康世, 金尚永, 柏田良樹, 高石喜久 :
ベニバナ(Carthamus tinctorius)脱脂種子に含有される機能性成分の探索研究(2)-,
第50回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, 109, 2011年11月. 靳美娜, 柏田良樹, 姚智, 段宏泉, 高石喜久 :
Shisandra propinquaの成分研究(1),
第50回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, 108, 2011年11月. 栗本慎一郎, 柏田良樹, 高石喜久 :
センダン科Azadirachta indicaの成分研究(1),
第50回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, 108, 2011年11月. 成相祐希, 水口博之, 永井浩章, 金山知代, 加藤周平, 柏田良樹, 根本尚夫, 高石喜久, 武田憲昭, 福井裕行 :
苦参由来新規抗アレルギー成分 maackiain の単離・合成および作用機序に関する研究,
第 50 回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, 2011年11月. 柴山恵美子, 柏田良樹, 土橋良太, 金城順英, 清水寛, 高石喜久 :
エラグ酸誘導体の肝保護作用について,
第50回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, 109, 2011年10月. 佐々木久子, 柏田良樹, 柴田洋文, 高石喜久 :
ミソナオシDesmodium caudatumの成分研究(5)-含有成分の抗MRSA・抗真菌活性について-,
日本生薬学会第58回年会, 324, 2011年9月. 大道由佳, 栗本慎一郎, 柏田良樹, 柴田洋文, 高石喜久, 三宅美行, 桐本吏 :
抗インフルエンザ活性天然物に関する研究(2)-金銀花(Lonicera japonica)の成分について-,
日本生薬学会第58回年会, 177, 2011年9月. 石井康世, 柏田良樹, 高石喜久 :
ベニバナ(Carthamus tinctorius)脱脂種子に含有される機能性成分の探索研究,
日本生薬学会第58回年会, 162, 2011年9月. Ahmed Ali Fakhruddin, 金尚永, 栗本慎一郎, 佐々木久子, 柴田洋文, 柏田良樹, 高石喜久 :
バングラデシュ産薬用植物に関する研究(1)-マメ科植物Butea monosperma花部について-,
日本生薬学会第58回年会, 85, 2011年9月. 成相祐希, 水口博之, 金山知代, 加藤周平, 永井浩章, 柏田良樹, 根本尚夫, 高石喜久, 武田憲昭, 福井裕行 :
苦参から見出された新規抗アレルギー成分 maackiain の単離・同定およびその性質について,
第15回活性アミンに関するシンポジウム, 2011年8月. 福井裕行, 金山知代, 加藤周平, 成相祐希, 馬場祐子, 水口博之, 柏田良樹, 根本尚夫, 高石喜久 :
苦参由来 IL-4 遺伝子発現抑制物質,
第28回和漢医薬学会学術大会, 2011年8月. 赤池雅史, 土屋浩一郎, 柏田良樹, 高石喜久, 玉置俊晃, 岩瀬俊, 佐田政隆, 粟飯原賢一, 吉田守美子, 松本俊夫, 佐藤千穂, 西条伴香, 楊河宏章 :
生活習慣病関連リスクファクターに及ぼすスダチ果皮加工品の効果 ∼探索的臨床試験による検討∼,
第243回徳島医学会学術集会公開シンポジウム, 2011年7月. 赤池雅史, 土屋浩一郎, 柏田良樹, 高石喜久, 玉置俊晃, 岩瀬俊, 佐田政隆, 粟飯原賢一, 吉田守実子, 松本俊夫, 佐藤千穂, 西条伴香, 楊河宏章 :
生活習慣病関連リスクファクターに及ぼすスダチ果皮加工品の効果-探索的臨床試験による検討-,
第243回徳島医学会学術集会, 2011年7月. 佐々木久子, 柏田良樹, 柴田洋文, 高石喜久 :
ミソナオシDesmodium caudatumの成分研究(4),
日本薬学会第131年会講演要旨集, Vol.2, 238, 2011年3月. 大道由佳, 柏田良樹, 柴田洋文, 高石喜久 :
抗インフルエンザ活性天然物に関する研究(1)―金銀花(Lonicera japonica)について,
日本薬学会第131年会講演要旨集, Vol.2, 244, 2011年3月. 熊娟, 谷口昌聖, 柏田良樹, 高石喜久 :
多剤薬剤耐性克服作用を有する天然物に関する研究(10)―シラカバ花穂トリテルペンpapyriferic acid のアミド誘導体の耐性克服作用―,
日本薬学会第131年会講演要旨集, Vol.2, 249, 2011年3月. 栗本慎一郎, 柏田良樹, 李國雄, 高石喜久 :
センダン科Dysoxylum cumingianum の成分研究(4),
日本薬学会第131年会講演要旨集, Vol.2, 249, 2011年3月. 辻大輔, 難波建多郎, 浦上裕行, 辻耕平, 重永章, 大髙章, 柏田良樹, 高石喜久, 伊藤孝司 :
ヒトiPS細胞に対する神経分化誘導能を持つ新規化合物の探索,
日本薬学会第131年会, 2011年3月. 成相祐希, 水口博之, 金山知代, 加藤周平, 柏田良樹, 根本尚夫, 高石喜久, 武田憲昭, 福井裕行 :
苦参から見出された新規抗アレルギー成分maackiainの単離・同定およびその性質について (Isolation and characterization of new anti-allergenic compound, maackiain from Kujin),
日本薬学会年会, 2011年3月. 金尚永, 柏田良樹, 川添和義, 村上光太郎, 孫漢董, 李順林, 高石喜久 :
雲南省産伝統薬物に関する研究 (17) - Chloranthus spicatus の成分について (9) -,
日本薬学会第131年会講演要旨集, Vol.2, 83, 2011年3月. 柏田良樹 :
天然資源からの治療薬創製研究ー抗HIV 薬，多剤薬剤耐性腫瘍克服薬創製を目指してー,
日本農芸化学会中四国支部第29回講演会講演要旨集, 9, 2011年1月. 成相祐希, 水口博之, 金山知代, 永井浩章, 加藤周平, 柏田良樹, 根本尚夫, 高石喜久, 武田憲昭, 福井裕行 :
苦参から見出された新規抗アレルギー成分maackiainの単離・同定およびその性質について,
2010感染免疫クラスター・ミニリトリート, 2011年1月. 葛西彩香, 木下正文, 足立美佳, 盛重純一, 瓜倉真衣, 里内清, 柏田良樹, 今林潔, 高石喜久, 田中保, 德村彰 :
種々の食材中の創傷治癒性リン脂質含量,
日本農芸化学会中国四国支部第29回講演会，講演要旨集, 28, 2011年1月. 水口博之, 金山知代, 成相祐希, 加藤周平, 柏田良樹, 根本尚夫, 川添和義, 高石喜久, 福井裕行 :
和漢薬苦参に見いだされたアレルギー疾患感受性遺伝子発現抑制作用を有する新規抗アレルギー化合物の同定,
BMB2010,第33回日本分子生物学会年会第83回日本生化学会大会合同大会, 2010年12月. 辻大輔, 難波建多郎, 浦上裕行, 重永章, 大髙章, 柏田良樹, 高石喜久, 伊藤孝司 :
未分化細胞に対する神経分化誘導作用を持つ化合物の探索と構造活性相関,
BMB2010(第33回日本分子生物学会年会・第83回日本生化学会大会合同大会), 2010年12月. 水口博之, 金山知代, 成相祐希, 永井浩章, 加藤周平, 柏田良樹, 根本尚夫, 川添和義, 高石喜久, 福井裕行 :
和漢薬苦参に見出されたアレルギー疾患感受性遺伝子発現抑制作用を有する新規抗アレルギー化合物の同定,
BMB2010, 2010年12月. 金子礼, 柏田良樹, 川添和義, 村上光太郎, 孫漢董, 李順林, 高石喜久 :
雲南省伝統薬物に関する研究(16)—Kadsura interiorの成分について(1)—,
第49回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会要旨集, 136, 2010年11月. 篠崎陽介, 柏田良樹, 高石喜久 :
オトギリソウ科Hypericum属植物に関する研究(24)—キンシバイHypericum patulum花部の成分について(4)—,
第49回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会要旨集, 135, 2010年11月. 佐々木久子, 柏田良樹, 柴田洋文, 高石喜久 :
ミソナオシDesmodium caudatumの成分研究(3),
第49回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会要旨集, 134, 2010年11月. 栗本慎一郎, 柏田良樹, 李國雄, 高石喜久 :
センダン科Dysoxylum cumingianumの成分研究(3),
第49回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会要旨集, 133, 2010年11月. 金尚永, 柏田良樹, 高石喜久, 川添和義, 村上光太郎, 孫漢董, 李順林 :
雲南省伝統薬物に関する研究(15)—Chloranthus spicatusの成分について(8)—,
第49回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会要旨集, 133, 2010年11月. 佐々木久子, 柏田良樹, 柴田洋文, 高石喜久 :
ミソナオシDesmodium caudatumの成分研究(3),
第49回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, 2010年11月. 金尚永, 柏田良樹, 高石喜久, 川添和義, 村上光太郎, 孫漢董, 李順林 :
雲南省伝統薬物に関する研究(14)—Chloranthus spicatusの成分について(7)—,
本生薬学会第57回年会, 302, 2010年10月. 金山知代, 水口博之, 加藤周平, 成相祐希, 柏田良樹, 根本尚夫, 高石喜久, 福井裕行 :
苦参に含まれるアレルギー疾患感受性遺伝子発現を標的とする新規抗アレルギー成分の単離と同定,
第14回日本ヒスタミン学会, 2010年10月. 栗本慎一郎, 柏田良樹, 高石喜久, 李國雄 :
センダン科Dysoxylum cumingianumの成分研究(2),
日本生薬学会第57回年会要旨集, 366, 2010年9月. 田中直伸, 大谷美央, 小林淳一, 柏田良樹, 高石喜久, 芝崎あずさ, 五ノ井透, 城始勇 :
ナガサキオトギリより単離した新規prenylated acylphloroglucinol, petiolin J-Mの構造,
日本生薬学会第57回年会要旨集, 363, 2010年9月. 佐々木久子, 柏田良樹, 柴田洋文, 高石喜久 :
ミソナオシDesmodium caudatumの成分研究(2),
日本生薬学会第57回年会講演要旨集, 342, 2010年9月. 金山知代, 水口博之, 加藤周平, 成相祐希, 柏田良樹, 根本尚夫, 高石喜久, 福井裕行 :
苦参に含まれるアレルギー疾患感受性遺伝子発現抑制物質の単離と同定,
第27回和漢医薬学会, 2010年8月. 熊娟, 谷口昌聖, 柏田良樹, 高石喜久, 山岸喬 :
Dammarane Triterpenes from the Floral Spikes of Betula platyphylla var. japonica,
日本生薬学会第57回年会要旨集, 359, 2010年8月. 金山知代, 水口博之, 加藤周平, 成相祐希, 柏田良樹, 根本尚夫, 高石喜久, 福井裕行 :
苦参に含まれるアレルギー疾患感受性遺伝子発現抑制物質の単離と同定,
第117回日本薬理学会近畿部会, 2010年7月. 辻大輔, 小山毅, 浦上裕行, 難波建多郎, 柏田良樹, 高石喜久, 伊藤孝司 :
ヒガンバナ科植物由来アルカロイドLycorineの神経分化誘導作用,
第51回日本生化学会中国・四国支部例会, 2010年5月. 田中直伸, 久保田高明, 柏田良樹, 高石喜久, 小林淳一 :
ナガサキオトギリより単離した新規benzophenone rhamnosideの構造,
日本薬学会第130年会, No.2, 233, 2010年3月. 栗本慎一郎, 柏田良樹, Lee Kuo-Hsiung, 高石喜久 :
センダン科Dysoxy cumingianumの成分研究,
日本薬学会第130年会, No.2, 233, 2010年3月. 田中美音, 柏田良樹, 高石喜久 :
Triterpene Glycosides from Una de Gato (Uncaria tomentosa).,
日本薬学会第130年会, No.2, 225, 2010年3月. 佐々木久子, 柏田良樹, 柴田洋文, 高石喜久 :
ミソナオシDesmodium caudatumの成分研究,
日本薬学会第130年会, No.2, 224, 2010年3月. 熊娟, 柏田良樹, Chen Chin-Ho, Lee Kuo-Hsiung, 高石喜久 :
Research on Anti-HIV Natural Products (25) –Betulin Derivatives and AZT conjugates as Anti-HIV Agents with Multi-Mechanisms of Action-,
日本薬学会第130年会, No.2, 222, 2010年3月. 柴山恵美子, 柏田良樹, 関谷倫子, 高石喜久 :
多剤耐性克服作用を有する天然物に関する研究(9)—エラグ酸誘導体のp糖タンパク質昨日に及ぼす影響—,
日本薬学会第130年会, Vol.2, 221, 2010年3月. 高石喜久, 柏田良樹, 橋田和佳, 北岡信, 三口弘介, 中川剛夫, 土屋浩一郎, 井端和郎 :
スダチ(Citrus sudachi)果皮のSIRT1活性化成分について,
第3回食品薬学シンポジウム, 114-116, 2009年11月. 佐々木久子, 岡本由梨恵, 柏田良樹, 川添和義, 村上光太郎, 李順林, 高石喜久 :
雲南省産伝統薬物に関する研究(13) -根辣Schizomussaenda dehiscensの成分研究(1)-,
第48回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, 2009年11月. 篠崎陽介, 橋田和佳, 柏田良樹, 高石喜久 :
オトギリソウ科Hypericum属植物に関する研究(23) -キンシバイHypericum patulum花部の成分について(3)-,
日本生薬学会第56回年会, 270, 2009年10月. 栗本慎一郎, 西村和也, 柏田良樹, 高石喜久 :
夏蠟梅Sinocalycanthus chinensisの成分研究(2),
日本生薬学会第56回年会, 259, 2009年10月. 金尚永, 柏田良樹, 高石喜久, 関谷倫子, 池城安正, Ramos Freddy :
Inula helenium葉含有セスキテルペンの細胞毒性活性,
日本生薬学会第56回年会, 109, 2009年10月. 柏田良樹, 熊娟, R. Nicole Kirgore, T. Carl Wirl, P. Graham Allaway, Kuo-Hsiung Lee, 高石喜久 :
抗HIV天然物に関する研究 (23) -ベツリンをリードとしたマルチメカニズムな抗HIV活性分子の創成研究-,
日本薬学会第129年会, No.2, 226, 2009年3月. 熊娟, 谷口昌聖, 柏田良樹, 山岸喬, 高石喜久 :
Research on Plant-Derived MDR-Reversing Agents (7): Amide Derivatives of Papyriferic Acid as MDR-reversing Agents.,
日本薬学会第129年会, No.2, 227, 2009年3月. 佐々木久子, 阿部有里子, 柏田良樹, 関谷倫子, 池城安正, 高石喜久 :
前駆脂肪細胞の分化調節機能を有する天然物(4)—青ジソ根部の分化抑制作用成分について—,
日本薬学会第129年会, No.2, 208, 2009年3月. 栗本慎一郎, 鈴木恭子, 岡坂衛, 柏田良樹, 伊藤美千穂, 本多義昭, 武田美雄, Kodzhimatov K. Olimjon, Ashurmetov Ozodbek, 高石喜久 :
ウズベキスタン産薬用植物に関する研究(36)—Ferula variaの成分研究(4) —,
薬学会第129年会, No.2, 227, 2009年3月. 金尚永, 柏田良樹, 川添和義, 村上光太郎, 孫漢董, 李順林, 高石喜久 :
雲南省産伝統薬物に関する研究(12)—Chloranthus spicatus の成分について(6)—,
薬学会第129年会, No.2, 96, 2009年3月. 田中直伸, 大豆村拓自, 久保田高明, 今林潔, 柏田良樹, 高石喜久, 小林淳一 :
ビヨウヤナギより単離した新規xanthone誘導体の構造,
日本薬学会第129年会, No.2, 172, 2009年3月. 篠崎陽介, 橋田和佳, 柏田良樹, 高石喜久 :
オトギリソウ科Hypericum 属植物に関する研究(22)—キンシバイ(Hypericum patulum)花部の成分について(2)—,
第47回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, 206, 2008年11月. 金尚永, 柏田良樹, 川添和義, 村上光太郎, 孫漢董, 李順林, 高石喜久 :
雲南省産伝統薬物に関する研究(11)—Chloranthus spicatus の成分について(5)—,
第47回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, 199, 2008年11月. 金尚永, 柏田良樹, 川添和義, 村上光太郎, 李順林, 孫漢董, 高石喜久 :
Chloranthus spicatusの成分研究,
第50回天然有機化合物討論会, 339-344, 2008年9月. 鎌倉孝法, 柏田良樹, 柴田洋文, 樋口富彦, 高石喜久 :
キク科カレープラントHelichrysum itallicum subsp. serotinumの抗MRSA活性成分の探索研究,
日本生薬学会第55回(2008)年会, 279, 2008年9月. 海瀬貞夫, 柏田良樹, 高石喜久, 孫漢董, 橋田千佳 :
オトギリソウ科Hypericum属植物に関する研究(19) —遍地金Hypericum elodeoidesの成分について(2)—,
日本生薬学会第55回(2008)年会, 243, 2008年9月. 田中直伸, 久保田高明, 石山玄明, 柏田良樹, 高石喜久, 伊藤淳二, 三上㐮, 城始勇, 小林淳一 :
ナガサキオトギリ由来の新規フロログルシノール誘導体petiolin Dの構造,
日本生薬学会第55回(2008)年会, 188, 2008年9月. 金尚永, 柏田良樹, 川添和義, 村上光太郎, 李順林, 高石喜久 :
雲南省産伝統薬物に関する研究(9)—Chloranthus spicatusの成分について(4)—,
日本生薬学会第55回(2008)年会, 187, 2008年9月. 橋田千佳, 田中直伸, 柏田良樹, 高石喜久, 孫漢董 :
オトギリソウ科Hypericum属植物に関する研究(19) —遍地金Hypericum elodeoidesの成分について(1)—.,
日本生薬学会第55回(2008)年会, 103, 2008年9月. 篠崎陽介, 橋田和佳, 柏田良樹, 高石喜久 :
オトギリソウ科Hypericum属植物に関する研究(21) —キンシバイHypericum patulum花部の成分について(1)—.,
日本生薬学会第55回(2008)年会, 102, 2008年9月. 栗本慎一郎, 鈴木恭子, 柏田良樹, 高石喜久, 岡坂衛, Kodozhimatov K. Olimjon, Ashurmetov Ozodbek :
ウズベキスタン産薬用植物に関する研究(35)—Mediasia macrophyllaの成分について(2)—.,
日本生薬学会第55回(2008)年会, 101, 2008年9月. 西村和也, 柏田良樹, 高石喜久 :
雲南省産伝統薬物に関する研究(10)—夏蝋梅(Sinocalycanthus chinensis)の成分について—.,
日本生薬学会第55回(2008)年会, 86, 2008年9月. 三橋洋介, 柏田良樹, 石田俊介, 高石喜久, Kodozhimatov K. Olimjon, Ashurmetov Ozodbek :
ウズベキスタン産薬用植物に関する研究(34) —Ziziphora pedicellataの成分について(2)—,
日本生薬学会第55回(2008)年会, 85, 2008年9月. 鎌倉孝法, 三浦理恵, 柏田良樹, 関谷倫子, 一柳孝司, 池城安正, 高石喜久 :
前駆脂肪細胞の分化調節機能を有する天然物(3)—かきのもとの分化促進作用成分について—,
薬学会第129年会, No.2, 208, 2008年3月. 田中直伸, 久保田高明, 荒木敦, 柏田良樹, 高石喜久, 三上襄, 小林淳一 :
ナガサキオトギリより単離した新規フロログルシノール誘導体petiolin A–Cの構造,
日本薬学会第128年会要旨集, 2008年3月.

(要約): -

金尚永, 柏田良樹, 高石喜久, 川添和義, 村上光太郎, 李順林 :
Chloranthus spicatusの成分研究,
日本薬学会第128年会要旨集, -, 2008年3月.

(要約): -

橋田和佳, 田中直伸, 柏田良樹, 高石喜久 :
Hypericum ascyronの成分研究 (5),
日本薬学会第128年会要旨集, -, 2008年3月.

(要約): -

柏田良樹, 高石喜久, Chin-Ho Chen, Kuo-Hsiung Lee :
抗HIV天然物に関する研究(22)–Oleanolic acid及びursolic acidの28-amido誘導体の抗HIV活性–,
日本薬学会第128年会要旨集, 2008年3月.

(要約): -

鈴木恭子, 岡坂衛, 柏田良樹, 高石喜久, 伊藤美千穂, 本多義昭, 武田美雄, Olimjon K. Kodzhimatov, Ozodbek Ashurmetov :
ウズベキスタン産薬用植物Ferula variaの成分研究(3),
日本薬学会第128年会要旨集, -, 2008年3月.

(要約): -

谷口昌聖, 熊娟, 柏田良樹, 高石喜久, 山岸喬 :
多剤薬剤耐性克服作用を有する点物に関する研究(5) –シラカバ花穂トリテルペノイドをリードとした抗がん剤耐性克服薬の創製研究–,
日本薬学会第128年会要旨集, 2008年3月.

(要約): -

阿部有里子, 柏田良樹, 高石喜久 :
青ジソ根部の有効利用に関する研究,
第46回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会要旨集, -, 2007年11月.

(要約): -

西村和也, 鎌倉孝法, 柏田良樹, 高石喜久, 柴田洋文, 樋口富彦 :
白コショウ(Piper nigrum)の成分研究,
第46回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会要旨集, 2007年11月.

(要約): -

橋田和佳, 田中直伸, 柏田良樹, 高石喜久 :
Hypericum ascyronの成分研究 (4),
第46回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会要旨集, 2007年11月.

(要約): -

東満美, 日野出晴美, 柏田良樹, 吉田昌裕, 山﨑尚志, 土屋浩一郎, 山内あい子, 柴田洋文, 新垣尚捷, 滝口祥令, 荒木勉, 吉村好之, 姫田敏樹, 石田竜弘, 辻大輔, 木原勝 :
徳島大学薬学部OSCEトライアル実施体制の確立と検証,
第17回日本医療薬学会年会, 2007年9月. 柏田良樹, 高石喜久, 柴田洋文, 樋口富彦, 黒川昌彦 :
エラグ酸誘導体の抗MRSA活性及び抗HSV活性,
第52回日本ブドウ球菌研究会要旨集, 2007年9月.

(要約): -

柏田良樹, 柴田洋文, 樋口富彦, 高石喜久 :
エラグ酸誘導体の抗菌活性について,
日本生薬学会第54年会, 2007年9月. 橋田和佳, 田中直伸, 柏田良樹, 高石喜久 :
Hypericum ascyronの成分研究(3),
日本生薬学会第54年会, 2007年9月. 鈴木恭子, 岡坂衛, 柏田良樹, 高石喜久, Kodzhimatov K. Olimjon, Ashurmetov Ozodbek, 本多義昭, 伊藤美千穂 :
ウズベキスタン産薬用植物Ferula variaの成分研究(2),
日本生薬学会第54年会, 2007年9月. 金尚永, 柏田良樹, 高石喜久, 川添和義, 村上光太郎, 李順林 :
Chloranthus spicataの成分研究,
日本生薬学会第54年会, 2007年9月. 柏田良樹 :
天然物からエイズ治療薬開発を目指す:抗HIVリード探索とその化学的修飾,
第7回国際バイオフォーラム, 2007年6月. 佐藤昌俊, 田中直伸, 柏田良樹, 高石喜久 :
桃花の成分研究,
薬学会第127年会, 2007年3月. 金尚永, Freddy Ramos, 廣野誠, 柏田良樹, 高石喜久, O.K. Kodzhimatov, Ozodbek Ashurmetov :
Inula helenium の成分研究,
日本薬学会第127年会, 2007年3月. 石田俊介, 岡坂衛, 柏田良樹, 高石喜久, O.K. Kodzhimatov, Ozodbek Ashurmetov :
Ziziphora pedicellataの成分研究,
日本薬学会第127年会, 2007年3月. 鎌倉孝法, 越智俊政, 柏田良樹, 高石喜久, 柴田洋文, 樋口富彦 :
メースMyristica fragrans)の成分研究,
日本薬学会第127年会, 2007年3月. 田中直伸, 柏田良樹, 高石喜久, 関田倫子, 池城安正 :
タカネオトギリ(hypericum sikokumontanum)より得たchromone glycosideについて,
日本薬学会第127年会, 2007年3月. 橋田和佳, 田中直伸, 柏田良樹, 高石喜久, 関田倫子, 池城安正 :
トモエソウHypericum ascyron)より得た細胞毒性を有するphloroglucinol誘導体及びxanthone誘導体について,
日本薬学会第127年会, 2007年3月. 岡坂衛, 柏田良樹, 高石喜久, O.K. Kodzhimatov, Ozodbek Ashurmetov :
ウズベキスタン薬用植物Mediasia macrophyllaの成分研究,
日本薬学会第127年会, 2007年3月. 柏田良樹, 高石喜久, Kilgore R. Nicole, Wild T. Carl, Allaway P. Graham, Lee Kuo-Hsiung :
抗HIV天然物に関する研究(20)-3-O-Glutaryl-betulin及び-dihydrobetulin ester誘導体の抗HIV活性―,
日本薬学会第127年会, 2007年3月. 関谷倫子, 池城安正, 鍋倉智裕, 柏田良樹, 北河修治, 田中隆, 河野功 :
多剤薬剤耐性克服作用を有する天然物に関する研究(4)—タンニン及び関連化合物のp糖タンパク質機能に及ぼす影響—,
日本薬学会第127年会, 2007年3月. 柏田良樹, 関谷倫子, 池城安正, 山岸喬, 高石喜久 :
シラカバ花穂含有トリテルペンの多剤耐性腫瘍細胞に対する回復作用とp-糖蛋白に及ぼす影響,
第16回天然薬物の開発と応用シンポジウム, 2006年11月. 岡坂衛, 石田俊介, 鈴木恭子, 柏田良樹, 高石喜久, 関谷倫子, 池城安正, 伊藤美千穂, 本多義昭, 武田美雄, O.K. Khodzhimatov, O.A. Ashurmetov :
ウズベキスタン産薬用植物の成分と活性に関する研究,
第16回天然薬物の開発と応用シンポジウム, 2006年11月. 山澤朋寛, 伊藤美千穂, 柏田良樹, 池田剛, 野原稔弘, 本多義昭 :
ベトナム産ケイヒのジテルペン成分の分析,
日本生薬学会第53回年会, 2006年9月. 柏田良樹, 高石喜久, 江口達也, 関谷倫子, 池城安正 :
Moringa(Moringa oleifera)葉の成分に関する研究(5)-α-glucosideを有するフエノール配糖体についてー,
日本生薬学会第53回年会, 2006年9月. 橋田和佳, 田中直伸, 柏田良樹, 高石喜久, 関谷倫子, 池城安正 :
トモエソウHypericum ascyron)より得た新規phloroglucinol誘導体の構造と細胞毒性について,
日本生薬学会第53回年会, 2006年9月. 橋田千佳, 田中直伸, 柏田良樹, 高石喜久 :
コゴメバオトギリより得られたhyperforinの類似化合物の構造について,
日本生薬学会第53回年会, 2006年9月. 岡坂衛, 柏田良樹, 高石喜久, O. K. Kodzhimatov, Ozodbek Ashurmetov :
ウズベキスタン薬用植物Paeonia hybridaの成分研究,
日本生薬学会第53回年会, 2006年9月. 石田俊介, 岡坂衛, Ferddy Ramos, 柏田良樹, 高石喜久, O. K. Kodzhimatov, Ozodbek Ashurmetov :
ウズベキスタン産薬用植物Condonopsis clematideaの成分研究,
日本生薬学会第53回年会, 2006年9月. 佐藤昌俊, 田中直伸, Ferddy Ramos, 柏田良樹, 高石喜久 :
桃花の成分研究,
日本生薬学会第53回年会, 2006年9月. 関谷倫子, 大貫敏明, 柏田良樹, 池城安正, 鍋倉智裕, 北河修治, 田中隆, 河野功 :
多剤薬剤耐性克服作用を有する天然物に関する研究(3)—タンニン及び関連化合物のp糖タンパク質機能に及ぼす影響—,
日本薬学会第126回年会, 2006年3月. 江口達也, 柏田良樹, 関谷倫子, 池城安正, 藤岡稔大, 石川行弘 :
Moringa (Moringa oleifera)葉の成分に関する研究(4)—Moringa葉のglucosinolateの構造にいて(2)—,
日本薬学会第126回年会, 2006年3月. 柏田良樹 :
トリテルペノイドから抗AIDS薬の開発を目指して,
天然薬物の開発と応用シンポジウム, 2005年11月. 関谷倫子, 柏田良樹, 池城安正, 一柳孝司, 小西徹也, 波田野義比古 :
脂肪細胞への分化促進を指標とした抗糖尿病物質の探索— 新潟県産食用菊「かきのもと」について —,
日本生薬学会第52回年会, 2005年9月. 江口達也, 柏田良樹, 関谷倫子, 池城安正, 石川行弘 :
Moringa(Moringa oleifera)葉の成分に関する研究(3)- Moringa葉のglucosinolate類の構造について-,
日本生薬学会第52回年会, 2005年9月. 関谷倫子, 柏田良樹, 池城安正, 鍋倉智裕, 北河修治, 山岸喬 :
多剤薬剤耐性克服作用を有する天然物に関する研究(2):シラカバ花穂のトリテルペンのp糖タンパク機能に及ぼす影響,
日本薬学会125年会, 2005年3月. 柏田良樹, 関谷倫子, 池城安正, Kilgore R. N., Wild T. C., Allaway P. G., Lee K.H. :
抗HIV天然物に関する研究 -シラカバ樹皮の成分より誘導される強力な抗HIV活性化合物-,
日本薬学会125年会, 2005年3月. 関谷倫子, 柏田良樹, 池城安正, 山岸喬 :
多剤薬剤耐性克服作用を有する天然物に関する研究シラカバ花穂のトリテルペンについて, --- 抗HIV天然物に関する研究(18)- PA-457関連ベツリン酸誘導体の抗HIV活性 - ---,
日本生薬学会第51回年会, 2004年9月. 柏田良樹, 関谷倫子, 池城安正, Kilgore N.R., Lee K.H. :
--- 抗HIV天然物に関する研究(18)- PA-457関連ベツリン酸誘導体の抗HIV活性 - ---,
日本生薬学会第51回年会, 2004年9月. 柏田良樹, 関谷倫子, 池城安正, 石川行弘, 川村良治 :
Moringa(Moringa oleifera)葉の抗酸化作用成分の検索(2),
日本薬学会第124年会要旨集, 2004年3月.

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特許: 福元隆俊, 柏田良樹, 田中直伸, 嵯峨山和美 : 乳頭細胞増殖促進剤，線維芽細胞増殖因子-7(FGF-7)産生促進剤，血管内皮増殖因子(VEGF)産生促進剤，インシュリン様増殖因子-1(IGF-1)産生促進剤，肝細胞増殖因子(HGF)産生促進剤，および育毛剤, 特願PCT/JP2018/024979 (2018年6月), 特許第WO 2019/004479 A1号. 福元隆俊, 柏田良樹, 田中直伸, 嵯峨山和美 : 乳頭細胞増殖促進剤，線維芽細胞増殖因子-7(FGF-7)産生促進剤，血管内皮増殖因子(VEGF)産生促進剤，インシュリン様増殖因子-1(IGF-1)産生促進剤，肝細胞増殖因子(HGF)産生促進剤，および育毛剤, 特願大W201904582 (2018年6月), 特許第PCT/JP2018/024979号. 福元隆俊, 柏田良樹, 田中直伸, 嵯峨山和美 : 乳頭細胞増殖促進剤，線維芽細胞増殖因子-7(FGF-7)産生促進剤，血管内皮増殖因子(VEGF)産生促進剤，インシュリン様増殖因子-1(IGF-1)産生促進剤，肝細胞増殖因子(HGF)産生促進剤，および育毛剤, 特願2019-505005 (2018年6月), (2019年10月), 特許第6582322号. 福元隆俊, 柏田良樹, 田中直伸, 嵯峨山和美 : 乳頭細胞増殖促進剤，線維芽細胞増殖因子-7(FGF-7)産生促進剤，血管内皮増殖因子(VEGF)産生促進剤，インシュリン様増殖因子-1(IGF-1)産生促進剤，肝細胞増殖因子(HGF)産生促進剤，および育毛剤, 特願2019-505005 (2018年6月), (2019年10月), 特許第ZL201880043433.1号 (2023年11月). 福元隆俊, 柏田良樹, 田中直伸, 嵯峨山和美 : 乳頭細胞増殖促進剤，線維芽細胞増殖因子-7(FGF-7)産生促進剤，血管内皮増殖因子(VEGF)産生促進剤，インシュリン様増殖因子-1(IGF-1)産生促進剤，肝細胞増殖因子(HGF)産生促進剤，および育毛剤, (2017年6月), 特許第2017-129244号 (2017年6月). 内田勝幸, 木村勝紀, 溝口智奈弥, 福井裕行, 武田憲昭, 柏田良樹, 水口博之 : 抗アレルギー剤およびインターロイキン4遺伝子発現抑制剤，ならびにそれらの製造方法および使用方法, (2016年3月), 特許第PCT/JP2016/57701号 (2016年). 内田勝幸, 木村勝紀, 溝口智奈弥, 福井裕行, 武田憲昭, 柏田良樹, 水口博之 : 抗アレルギー剤およびインターロイキン4遺伝子発現抑制剤，ならびにそれらの製造方法および使用方法, (2015年3月), 特許第2015-048286号 (2015年). 福井裕行, 高石喜久, 水口博之, 柏田良樹, 根本尚夫 : アレルギー疾患感受性遺伝子発現抑制物質, 特願2009-284069 (2009年12月), 特許第PCT/KR2010/008995号 (2009年12月).
作品: Yoshiki Kashiwada :
Development of Natural Product-Derived Chemotherapeutic Agents: Search and Modification of Potential Natural Product-Leads,
Jun. 2010.
補助金・競争的資金: カバノアナタケを素材とした新しい発毛・育毛剤の開発研究 (研究課題/領域番号: 20K07113 )
植物由来のメロテルペンをテンプレートとした抗HIV薬の開発研究 (研究課題/領域番号: 17K08337 )
トリテルペンを創薬テンプレートとしたデュアルメカニズムの抗HIV薬創製研究 (研究課題/領域番号: 15K07998 )
鏡像体タンパク質を用いた医薬品探索技術の開発と実証 (研究課題/領域番号: 15H04653 )
モンゴル民族の伝統薬物調査とその有効利用に関する研究（第2次） (研究課題/領域番号: 26305003 )
薬剤耐性 HIV 克服を目指した抗 HIV 薬の創製研究 (研究課題/領域番号: 22510233 )
モンゴル民族の伝統薬物調査とその有効利用に関する研究 (研究課題/領域番号: 22406024 )
中国雲南省少数民族の伝統薬物調査とその有効利用に関する研究(第二次) (研究課題/領域番号: 18406028 )
ヒスタミンH_1受容体遺伝子発現機構を標的とする新規アレルギー治療法 (研究課題/領域番号: 18390167 )
腫瘍細胞増殖抑制作用,抗HIV作用を指標とした邦産、雲南省産植物成分の研究 (研究課題/領域番号: 12672080 )
天然に広く分布するトリテルペノイドをリード化合物とした抗HIV薬の共同開発研究 (研究課題/領域番号: 11694321 )
北部日本に自生する植物の抗HIV活性化合物の検索研究 (研究課題/領域番号: 10672009 )
各種トリテルペノイドをリード化合物とした抗HIV薬の共同開発研究 (研究課題/領域番号: 09044339 )
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2024年11月15日更新

専門分野・研究分野: 天然物化学 (Natural Products Chemistry)
生薬学 (Pharmacognosy)
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受賞: 2020年2月, 康楽賞 (公益社団法人康楽会)
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Jグローバル最終確認日: 2024/11/9 01:19
氏名（漢字）: 柏田良樹
氏名（フリガナ）: カシワダヨシキ
氏名（英字）: Kashiwada Yoshiki
所属機関: 旧所属新潟薬科大学薬学部助教授

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researchmap最終確認日: 2024/11/10 01:13
氏名（漢字）: 柏田良樹
氏名（フリガナ）: カシワダヨシキ
氏名（英字）: Kashiwada Yoshiki
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登録日時: 2010/1/25 00:00
更新日時: 2022/9/3 07:58
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研究者番号: 30169429

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所属（過去の研究課題 情報に基づく）*注記: 2018/4/1 – 2022/4/1 : 徳島大学, 大学院医歯薬学研究部(薬学域), 教授
2018/4/1 : 徳島大学, ヘルスバイオサイエンス研究部, 教授
2016/4/1 – 2017/4/1 : 徳島大学, 大学院医歯薬学研究部(薬学系), 教授
2015/4/1 – 2016/4/1 : 徳島大学, 大学院医歯薬学研究部, 教授
2014/4/1 : 徳島大学, ヘルスバイオサイエンス研究部, 教授
2012/4/1 : 徳島大学, ヘルスバイオサイエンス研究部, 准教授
2010/4/1 – 2012/4/1 : 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 准教授
2007/4/1 – 2008/4/1 : 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 准教授
2002/4/1 : 新潟薬科大学, 薬学部, 助教授
2000/4/1 – 2002/4/1 : 新潟薬科大学, 助教授
1997/4/1 – 2000/4/1 : 新潟薬科大学, 薬学部, 助教授

審査区分/研究分野

研究代表者

生物系 / 医歯薬学 / 内科系臨床医学 / 内科学一般(含心身医学)
総合・新領域系 / 複合新領域 / 生体分子科学 / 生物分子科学
生物系 / 医歯薬学 / 薬学 / 天然資源系薬学
医学 / 薬学 / 医薬分子機能学
医学 / 薬学 / 化学系薬学

研究代表者以外

生物系 / 医歯薬学 / 境界医学 / 応用薬理学
生物系 / 医歯薬学 / 内科系臨床医学 / 内科学一般(含心身医学)
医学 / 薬学 / 化学系薬学
生物系 / 医歯薬学 / 薬学 / 天然資源系薬学
生物系 / 医歯薬学 / 薬学 / 創薬化学
小区分47050:環境および天然医薬資源学関連

キーワード

研究代表者

モンゴル民族 / 伝統薬物 / 薬用資源 / 国際情報交換 / モンゴル / 民族薬物 / AIDS / 薬剤耐性 / トリテルペン / ベツリン / 薬用植物 / 抗AIDS作用 / トリテルペノイド / ぺツリン酸 / オレアノール酸 / ウルソール酸 / ベツリン酸 / Anti-HIV / Triterpenoids / Betulinic acid / Oleanolic acid / Ursolic acid / betulinic acid / betulin / ursolic acid / triterpenoids / HIV / 抗HIV薬

研究代表者以外

ヒスタミン受容体 / アレルギー / 遺伝子発現 / ヒスタミンH_1受容体 / 疾患感受性遺伝子 / 鼻過敏症 / IL-4 / 天然物医薬 / 初期療法 / 蛋白キナーゼC-δ / スプラタスト / アレルギー疾患感受性遺伝子 / 科学的検証 / 個別化医療 / インターロイキン-4 / ヒスチジン脱炭酸酵素遺伝子 / 抗ヒスタミン薬 / ヒスタミン / ヒスタミンH1受容体 / ヒスチジン脱炭酸酵素 / グルココルチコイド / ブラウンノルウェイラット / トルエンジイソシアネート / 蛋白キナーゼC / 伝承医薬 / 民間医療 / 少数民族薬物 / 天然物化学 / 伝統薬物調査 / 雲南省 / 伝承薬物 / 民間薬 / 生薬学 / 伝承医薬品 / 中国雲南省 / 抗AIDS作用 / エゾムラサキツツジ / クロメン / クロマン / シラカバ / トリテルペン / Anti-HIV / Chromene / Chroman / Rhododendron dauricum / Betula platyphylla var.japonica / triterpenoids / 腫瘍細胞増殖抑制植物成分 / ヒト胃癌細胞(MK-1) / ヒト子宮頸癌細胞(HeLa) / マウスメラノーマ細胞(B16F10) / タンニン及び関連化合物 / フラボノイド / フェニルエタノイド配糖体 / トリテルペノイド / 腫瘍細胞増殖抑制作用 / マツカゼソウ / Lippia cancescens / Inula helenium / クマリン / フラボン / セスキテルペン / クマツヅラ科植物 / アレチハナガサ / コバノランタナ / ポリフェノール / 腫瘍細胞増殖抑制 / ヒト胃ガン細胞 / ヒト子宮頚ガン細胞 / マウス悪性メラノーマ細胞 / 抗腫瘍活性植物成分 / Antiproliferative Constituents / Human stomach cancer / Human uterine cancer / Mouse melanoma / Tannins / Flavonoids / Phenylethanoid glycosides / Triterpenoids / 抗HIV薬 / 天然物 / メロテルペン / 植物 / 海洋生物 / 抗HIV活性物質 / 薬学 / ペプチド / キラル化合物 / スクリーニング / 医薬品探索 / SH2ドメイン / カスパーゼ / BIRドメイン / 天然資源 / カバノアナタケ / 発毛・育毛剤 / ヒト頭髪毛乳頭細胞 / ステロール

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柏田 良樹

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柏田良樹