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角田奈美

徳島大学

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2024年11月15日更新

職名: 准教授
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学歴: 2004/3: 徳島大学医学部医学科卒業
学位: 博士(医学) (徳島大学)
学士(医学) (徳島大学) (2004年3月)
職歴・経歴: 2010/5: 徳島大学特任助教, 病院 (-2011.3.)
2011/4: 徳島大学助教, 病院 (-2015.1.)
2015/2: 徳島大学助教, 大学院ヘルスバイオサイエンス研究部 (-2015.3.)
2015/4: 徳島大学助教, 大学院医歯薬学研究部 (-2018.12.)
2019/1: 徳島大学講師, 病院 (-2019.5.)
2019/6: 徳島大学講師, 大学院医歯薬学研究部 (-2021.9.)
2021/10: 徳島大学准教授, 大学院医歯薬学研究部

専門分野・研究分野: 医学 (Medicine)

研究者総覧で最新データを確認する

2024年11月15日更新

専門分野・研究分野: 医学 (Medicine)
担当経験のある授業科目: 呼吸器コース(3年) (学部)
臨床医学入門コース (学部)
臨床実習入門(講義) (学部)
指導経験: 研究者総覧に該当データはありませんでした。

研究者総覧で最新データを確認する

2024年11月15日更新

専門分野・研究分野: 医学 (Medicine)

研究テーマ: 研究者総覧に該当データはありませんでした。

著書

田中克哉, 角田奈美, 米澤宏記 :
臨床麻酔薬理学書 10章抗不整脈薬関連日本麻酔科医会連合出版部編,
中山書店, 2023年12月. 田中克哉, 角田奈美 :
新戦略に基づく麻酔・周術期医学麻酔科医のための周術期の診療ガイドライン活用術, --- 2章症例で学ぶ診療ガイドラインの実践・術前管理 2-2 循環評価 ---,
株式会社中山書店, 東京, 2020年6月.

論文

Michiko Kinoshita, Makoto Kinoshita, Rikako Takahashi, Sarara Mutoh, Nami Kakuta and Katsuya Tanaka :
The Safety and Strategies for Reinitiating Electroconvulsive Therapy After ECT-Induced Takotsubo Cardiomyopathy: A Case Report and Systematic Review.,
The Journal of ECT, Vol.39, No.3, 185-192, 2023.

(要約): Electroconvulsive therapy-induced TCM is more likely to cause cardiogenic shock than nonperioperative cases; nevertheless, it has good prognosis. Cautious reinitiation of ECT after TCM recovery is possible. Further studies are required to determine preventive measures for ECT-induced TCM.
(キーワード): electroconvulsive therapy / takotsubo cardiomyopathy / systematic review
(徳島大学機関リポジトリ): ● Metadata: 118060
(出版サイトへのリンク): ● Publication site (DOI): 10.1097/YCT.0000000000000905
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36897138; ● Summary page in Scopus @ Elsevier: 2-s2.0-85169185042

(徳島大学機関リポジトリ: 118060, DOI: 10.1097/YCT.0000000000000905, PubMed: 36897138, Elsevier: Scopus) Ryo Sekiguchi, Michiko Kinoshita, Ryosuke Kawanishi, Nami Kakuta, Yoko Sakai and Katsuya Tanaka :
Comparison of hemodynamics during induction of general anesthesia with remimazolam and target-controlled propofol in middle-aged and elderly patients: a single-center, randomized, controlled trial.,
BMC Anesthesiology, 2023.

(要約): MAP decreased after induction of anesthesia in both groups, without significant differences between the groups (- 41.1 [16.4] mmHg and - 42.8 [10.8] mmHg in remimazolam and propofol groups, respectively; mean difference: 1.7 [95% confidence interval: - 8.2 to 4.9]; p = 0.613). Furthermore, HR, CO, and SV decreased after induction in both groups, without significant differences between the groups. Remimazolam group had significantly shorter time until loss of consciousness than propofol group (1.7 [0.7] min and 3.5 [1.7] min, respectively; p < 0.001). However, MAP, HR, CO, and SV were not significantly different between the groups despite adjusting time until loss of consciousness as a covariate. Seven (35%) and 11 (55%) patients in the remimazolam and propofol groups, respectively, experienced hypotension (MAP < 65 mmHg over 2.5 min), without significant differences between the groups (p = 0.341).
(キーワード): Adult / Aged / Middle Aged / Humans / Propofol / Piperidines / Hemodynamics / Anesthesia, General / Hypotension / Unconsciousness / Anesthetics, Intravenous
(徳島大学機関リポジトリ): ● Metadata: 117916
(出版サイトへのリンク): ● Publication site (DOI): 10.1186/s12871-023-01974-9
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36624371; ● Search Scopus @ Elsevier (PMID): 36624371; ● Search Scopus @ Elsevier (DOI): 10.1186/s12871-023-01974-9

(徳島大学機関リポジトリ: 117916, DOI: 10.1186/s12871-023-01974-9, PubMed: 36624371) Mayu Sebe, Rie Tsutsumi, Takuro Oyama, T Yousuke Horikawa, Yuta Uemura, Nami Kakuta, Yoko Sakai, Atsushi Morio, Hirotsugu Miyoshi, Takashi Kondo, Tomoaki Urabe, Yuko Noda, Satoshi Kamiya, Noboru Saeki, Masashi Kuroda, Katsuya Tanaka, Yasuo Tsutsumi and Hiroshi Sakaue :
Assessment of postoperative nutritional status and physical function between open surgical aortic valve replacement and transcatheter aortic valve implantation in elderly patients.,
The Journal of Medical Investigation : JMI, Vol.67, No.1.2, 139-144, 2020.

(要約): Background and aims : Severe aortic stenosis (AS) has been normally treated with surgical aortic valve replacement (AVR) whereas recently, transcatheter aortic valve implantation (TAVI) has been introduced as a minimally invasive operation for patients with high surgical risk and frailty. In this study, we have evaluated postoperative physical function and nutrition intake in the patients following AVR and TAVI. Methods : This prospective observational study involved 9 patients with surgical aortic valve replacement (AVR) and 7 patients with transcatheter aortic valve implantation (TAVI). Body composition was measured one day prior surgery, postoperative day (POD) 1, POD 3, POD 5 and POD 7. Hand grip strength, calf circumference and gait speed were measured one day before surgery and on the day of discharge. Results : Skeletal muscle was significantly decreased in AVR patients at postoperative day 3 and 7, while there was no change in TAVI patients. Patients with TAVI showed higher dietary intake after surgery compared to patients with AVR, and they maintained hand grip strength and calf circumference at discharge. Conclusions : In elderly patients with AS, TAVI can improve post-operative recovery maintaining nutritional status and physical function even. J. Med. Invest. 67 : 139-144, February, 2020.
(徳島大学機関リポジトリ): ● Metadata: 114644
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.67.139
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32378597; ● Search Scopus @ Elsevier (PMID): 32378597; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.67.139

(徳島大学機関リポジトリ: 114644, DOI: 10.2152/jmi.67.139, PubMed: 32378597) Nami Kakuta, Shinji Kawahito, Naoji Mita, Tomohiro Soga, Shusuke Yagi, Shiho Satomi, Fumihiko Tada, Kinoshita Hiroyuki, Kazumi Takaishi and Hiroshi Kitahata :
Continuous blood glucose monitoring during pediatric cardiopulmonary bypass.,
Clinical Pediatric Anesthesia, Vol.25, No.1, 3-7, 2019.

(徳島大学機関リポジトリ): ● Metadata: 113628
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1050564288848711808

(徳島大学機関リポジトリ: 113628, CiNii: 1050564288848711808) Shinji Kawahito, Naoji Mita, Tomohiro Soga, Shusuke Yagi, Nami Kakuta, Shiho Satomi, Hiroyuki Kinoshita, Kazumi Takaishi, Tetsuya Kitagawa and Hiroshi Kitahata :
Accuracy and reliability of continuous blood glucose monitoring during pediatric cardiopulmonary bypass.,
Journal of Artificial Organs, Vol.22, No.4, 353-356, 2019.

(要約): The purpose of this study was to assess the accuracy and reliability of a continuous blood glucose monitoring system (artificial endocrine pancreas; STG-55, Nikkiso, Tokyo, Japan) during pediatric cardiopulmonary bypass surgery. Twenty-five pediatric patients scheduled to undergo cardiovascular surgery with cardiopulmonary bypass (age 4 months to 11 years; body weight 5.6-59.7 kg) were enrolled. The glucose sensor line of the artificial endocrine pancreas was connected to the venous side of the cardiopulmonary bypass circuit and used for continuous blood glucose monitoring. We obtained 192 samples for blood gas assessment from the cardiopulmonary bypass circuit, and i-STAT (Abbott, East Windsor, NJ, USA) was used for conventional blood glucose assessment. The accuracies of continuous glucose measurements (STG-55) and conventional intermittent glucose measurements (i-STAT) during cardiopulmonary bypass were compared by means of Clarke error grid analysis. The results were divided into five zones, A, B, C, D, and E, and 78.6% of paired measurements were in zone A, while 21.4% were in zone B. We confirmed that the results of this continuous blood glucose monitoring system for cardiopulmonary bypass during pediatric cardiovascular surgery were highly reliable. An artificial endocrine pancreas may facilitate the safe use of intensive insulin therapy during pediatric cardiovascular surgery.
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s10047-019-01111-9
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31236730; ● Search Scopus @ Elsevier (PMID): 31236730; ● Search Scopus @ Elsevier (DOI): 10.1007/s10047-019-01111-9

(DOI: 10.1007/s10047-019-01111-9, PubMed: 31236730) Yuta Uemura, Yoko Sakai, Yasuo Tsutsumi, Nami Kakuta, Chiaki Murakami, Shiho Satomi, Takuro Oyama, Naohiro Ohshita, Tomoya Takasago, Daisuke Hamada, Koichi Sairyo and Katsuya Tanaka :
Postoperative nausea and vomiting following lower limb surgery :a comparison between single-injection intraarticular anesthesia and continuous epidural anesthesia.,
The Journal of Medical Investigation : JMI, Vol.66, No.3.4, 303-307, 2019.

(要約): Study Objective : the incidence of postoperative nausea and vomiting (PONV) following single-injection intraarticular anesthesia was compared to that following continuous epidural anesthesia. Design : Prospective, double-blind, randomized study. Setting : University-affiliated teaching hospital. Patients : Forty-eight patients finally participated in this study, and each group contained twenty-four patients. Interventions : Patients scheduled to undergo lower limb surgery under general anesthesia were randomly allocated into two groups, to receive either single-injection intraarticular or continuous epidural anesthesia for postoperative analgesia. Measurements : The incidence and severity of PONV, complete response rates (i.e., no vomiting or rescue antiemetic use), and pain scores were recorded 2, 24, and 48 h postoperatively. Main results : No significant differences between groups were observed in the incidence and severity of PONV, rescue antiemetic use, or complete response rate at any of the time points, but only the use of rescue analgesics was significantly less in continuous epidural anesthesia group during the 2-24h postoperative period (P=0.04). Conclusion : While the use of single-injection intraarticular anesthesia following lower limb surgery did not prevent PONV more than continuous epidural anesthesia in this study, the intraarticular technique still provides greater simplicity, safety, and cost-effectiveness. J. Med. Invest. 66 : 303-307, August, 2019.
(徳島大学機関リポジトリ): ● Metadata: 114087
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.66.303
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31656294; ● Summary page in Scopus @ Elsevier: 2-s2.0-85074177528

(徳島大学機関リポジトリ: 114087, DOI: 10.2152/jmi.66.303, PubMed: 31656294, Elsevier: Scopus) Yuta Uemura, Nami Kakuta, Katsuya Tanaka and Yasuo Tsutsumi :
Anesthetic management of a patient with methylmalonic acidemia: a case report.,
JA Clinical Reports, Vol.4, No.1, 71, 2018.

(要約): Methylmalonic acidemia (MMA) is a metabolic disorder of organic acids and is characterized by the accumulation of methylmalonic acids. The patient was a 19-year-old female diagnosed with severe MMA at 3 days of age, who was scheduled for renal replacement therapy. Preoperatively, there was no evidence of metabolic acidosis or electrolyte abnormalities. Glucose was administered preoperatively following a 6-h fast. Anesthesia was administered using thiamylal, remifentanil, rocuronium, and sevoflurane. After tracheal intubation, the patient underwent an ultrasound-guided bilateral rectus sheath block with ropivacaine. A drop in blood sugar level was treated with 5% glucose. Extubation was performed after intravenous administration of sugammadex. We report the anesthetic management of a patient with MMA using a combination of general anesthesia and rectus sheath block.
(徳島大学機関リポジトリ): ● Metadata: 114561
(出版サイトへのリンク): ● Publication site (DOI): 10.1186/s40981-018-0209-7
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32025901; ● Search Scopus @ Elsevier (PMID): 32025901; ● Search Scopus @ Elsevier (DOI): 10.1186/s40981-018-0209-7

(徳島大学機関リポジトリ: 114561, DOI: 10.1186/s40981-018-0209-7, PubMed: 32025901) Shiho Satomi, Nami Kakuta, Chiaki Murakami, Yoko Sakai, Katsuya Tanaka and Yasuo Tsutsumi :
The Efficacy of Programmed Intermittent Epidural Bolus for Postoperative Analgesia after Open Gynecological Surgery: A Randomized Double-Blinded Study.,
BioMed Research International, Vol.2018, 6297247, 2018.

(要約): It is well known that the programmed intermittent epidural bolus (PIEB) technique effectively provides epidural anesthesia in labor. This randomized double-blind trial compared the postoperative analgesic efficacy of PIEB with that of continuous epidural infusion (CEI) in patients undergoing gynecological surgery under combined general-epidural anesthesia. Patients undergoing open gynecological surgery under combined general-epidural anesthesia were randomized at a 1 : 1 ratio to receive PIEB or CEI. In the PIEB group, the pump delivered 4L ropivacaine 0.2% plus fentanyl 2 g/mL every hour. In the CEI group, the pump delivered the same solution at a rate of 4L/h. In both groups, additional 4L boluses of ropivacaine 0.2% plus fentanyl 2 g/mL were provided, when necessary, by patient-controlled epidural analgesia after surgery. The primary outcome was the total ropivacaine dose 40 hours after surgery. The secondary outcomes were the number of PCEA boluses and postoperative pain (evaluated on an 11-point numerical rating scale) 3, 24, and 48 hours after surgery. In total, 57 patients were randomized ( = 28 and 29 in the PIEB and CEI groups, resp.). The two groups differ significantly in terms of the total ropivacaine dose 40 hours after surgery (mean (standard deviation): 155.38 (4.55) versus 159.73 (7.87)L, = 0.016). Compared to the CEI group, the PIEB group had significantly lower numerical rating scale scores 3 hours (median [lower-upper quartiles]: 0 [0-0.5] versus 3 [0-5.5], = 0.002), 24 hours (1 [0-2] versus 3 [1-4], = 0.003), and 48 hours (1 [0-2] versus 2 [2-3.5], = 0.002) after surgery. PIEB was better than CEI in terms of providing postoperative analgesia after open gynecological surgery under combined general-epidural anesthesia.
(キーワード): Adult / Aged / Analgesia, Epidural / Double-Blind Method / Female / Gynecologic Surgical Procedures / Humans / Middle Aged / Pain, Postoperative
(徳島大学機関リポジトリ): ● Metadata: 113336
(出版サイトへのリンク): ● Publication site (DOI): 10.1155/2018/6297247
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29862280; ● Search Scopus @ Elsevier (PMID): 29862280; ● Search Scopus @ Elsevier (DOI): 10.1155/2018/6297247

(徳島大学機関リポジトリ: 113336, DOI: 10.1155/2018/6297247, PubMed: 29862280) Takuro Oyama, Nami Kakuta, Naoji Mita, Shinji Kawahito, Katsuya Tanaka and Yasuo Tsutsumi :
Jelly-type carbohydrate supplement in healthy subjects suppresses the catabolism of adipose tissue and muscle protein and improved their satisfactions.,
Clinical Nutrition Experimental, Vol.19, 1-11, 2018.

(徳島大学機関リポジトリ): ● Metadata: 114662
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.yclnex.2018.04.002
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1016/j.yclnex.2018.04.002

(徳島大学機関リポジトリ: 114662, DOI: 10.1016/j.yclnex.2018.04.002) Nami Kakuta, Yasuo Tsutsumi, Chiaki Murakami, Yoko Sakai, Takuro Oyama, Asuka Kasai, Katsuyoshi Kume and Katsuya Tanaka :
Effectiveness of using non-invasive continuous arterial pressure monitoring with ClearSight in hemodynamic monitoring during living renal transplantation in a recipient:a case report.,
The Journal of Medical Investigation : JMI, Vol.65, No.1.2, 139-141, 2018.

(要約): We investigated the effectiveness of the ClearSight system for hemodynamic management during kidney transplantation for a recipient. The recipient was to receive a kidney transplant from his mother under general anesthesia. We used continuous noninvasive finger-cuff-based monitoring of blood pressure, provided by the ClearSight system, and stroke volume variation to predict fluid responsiveness. We used of a balanced anesthetic technique and stringent monitoring standards to ensure a successful outcome for the patient. This case demonstrated that ClearSight has the potential to improve patient monitoring in hemodynamically stable patients who received kidney transplantation under general anesthesia. J. Med. Invest. 65:139-141, February, 2018.
(キーワード): Adult / Arterial Pressure / Hemodynamic Monitoring / Humans / Kidney Transplantation / Male
(徳島大学機関リポジトリ): ● Metadata: 111450
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.65.139
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29593185; ● Search Scopus @ Elsevier (PMID): 29593185; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.65.139

(徳島大学機関リポジトリ: 111450, DOI: 10.2152/jmi.65.139, PubMed: 29593185) Yoko Sakai, Yasuo M. Tsutsumi, Takuro Oyama, Chiaki Murakami, Nami Kakuta and Katsuya Tanaka :
Noninvasive continuous blood pressure monitoring by the ClearSight system during robot-assisted laparoscopic radical prostatectomy.,
The Journal of Medical Investigation : JMI, Vol.65, No.1.2, 69-73, 2018.

(要約): Robot-assisted laparoscopic radical prostatectomy (RALRP) is commonly performed in the surgical treatment of prostate cancer. However, the steep Trendelenburg position (25) and pneumoperitoneum required for this procedure can sometimes cause hemodynamic changes. Although blood pressure is traditionally monitored invasively during RALRP, the ClearSight system (BMEYE, Amsterdam, The Netherlands) enables a totally noninvasive and simple continuous blood pressure and cardiac output monitoring based on finger arterial pressure pulse contour analysis. We therefore investigated whether noninvasive continuous arterial blood pressure measurements using the ClearSight system were comparable to those obtained invasively in patients undergoing RALRP. Ten patients scheduled for RALRP with American Society of Anesthesiologists physical status I-II were included in this study. At each of the seven defined time points, noninvasive and invasive blood pressure measurements were documented and compared in each patient using Bland-Altman analysis. Although the blood pressure measured with the ClearSight system correlated with that measured invasively, a large difference between the values obtained by the two devices was noted. The ClearSight system was unable to detect blood pressure accurately during RALRP, suggesting that blood pressure monitoring using this device alone is not feasible in this small patient population. J. Med. Invest. 65:69-73, February, 2018.
(キーワード): Aged / Blood Pressure Monitors / Humans / Laparoscopy / Male / Middle Aged / Prostatectomy / Robotic Surgical Procedures
(徳島大学機関リポジトリ): ● Metadata: 111413
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.65.69
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29593197; ● Search Scopus @ Elsevier (PMID): 29593197; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.65.69

(徳島大学機関リポジトリ: 111413, DOI: 10.2152/jmi.65.69, PubMed: 29593197) Chiaki Murakami, Nami Kakuta, Katsuyoshi Kume, Yoko Sakai, Asuka Kasai, Takuro Oyama, Katsuya Tanaka and Yasuo Tsutsumi :
A comparison of fosaprepitant and ondansetron for preventing postoperative nausea and vomiting in moderate to high risk patients: A retrospective database analysis.,
BioMed Research International, Vol.2017, 5703528, 2017.

(要約): Postoperative nausea and vomiting (PONV) occur in 30-50% of patients undergoing general anesthesia and in 70-80% of high PONV risk patients. In this study, we investigated the efficacy of fosaprepitant, a neurokinin-1 (NK1) receptor antagonist, compared to ondansetron, a selective 5-hydroxytryptamine type 3 (5-HT3) receptor antagonist, in moderate to high PONV risk patients from our previous randomized controlled trials. Patients (171 patients from 4 pooled studies) with the Apfel simplified score ≥ 2 and undergoing general anesthesia were randomly allocated to receive intravenous fosaprepitant 150 mg (NK1 group, = 82) and intravenous ondansetron 4 mg (ONS group, = 89) before induction of anesthesia. Incidence of vomiting was significantly lower in the NK1 group compared to the ONS group 0-2, 0-24, and 0-48 hours after surgery (2 versus 17%, 2 versus 28%, and 2 versus 29%, resp.). However, no significant differences in PONV, complete response, rescue antiemetic use, and nausea score were observed between groups 0-48 hours after surgery. In moderate to high PONV risk patients, fosaprepitant decreased the incidence of vomiting and was superior to ondansetron in preventing postoperative vomiting 0-48 hours after surgery.
(キーワード): Adult / Aged / Aged, 80 and over / Databases as Topic / Demography / Humans / Middle Aged / Morpholines / Ondansetron / Postoperative Care / Postoperative Nausea and Vomiting / Retrospective Studies / Risk Factors / Young Adult
(徳島大学機関リポジトリ): ● Metadata: 112392
(出版サイトへのリンク): ● Publication site (DOI): 10.1155/2017/5703528
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29410964; ● Search Scopus @ Elsevier (PMID): 29410964; ● Search Scopus @ Elsevier (DOI): 10.1155/2017/5703528

(徳島大学機関リポジトリ: 112392, DOI: 10.1155/2017/5703528, PubMed: 29410964) Yasuo Tsutsumi, Takuro Oyama, Nami Kakuta, YT Horikawa, Katsuyoshi Kume, Yoko Sakai, Rie Tsutsumi and Katsuya Tanaka :
Effect of oral carbohydrate with amino acid solution on serum oxidative/anti-oxidative status in healthy volunteers.,
Journal of Anesthesia, Vol.31, No.3, 472-475, 2017.

(要約): The aim of this work was to investigate the effect of oral carbohydrate with amino acid [oral nutritional supplement (ONS)] solution on oxidative stress in healthy persons. Fourteen healthy volunteers were segregated into control and ONS groups. Volunteers in the ONS group ingested 250 ml of Arginaid Water (Nestle Japan, Tokyo, Japan) in the evening before the experiment and at 7:00 am on the day of the experiment. Volunteers in the control group fasted after dinner and drank only water until 7:00 am on the day of the experiment. In both groups, blood was collected at 9:00 am. The serum total oxidant levels and antioxidant capacity were assessed by d-ROMs (derivatives of reactive oxygen metabolites) test and BAP (biological antioxidant potential) test, respectively. In the ONS group, the serum d-ROMs level was significantly lower than in the control group (297 ± 43 and 327 ± 41 U.CARR, respectively, p = 0.018), while the serum BAP level was significantly higher than the control group (2410 ± 432 and 1979 ± 397 µmol/l, respectively, p = 0.005). The OXY level of Arginaid Water was much higher than preOp drink (Nutricia, Ireland). In conclusion, our study showed that an ONS with arginine loading could decrease oxidative stress and increase antioxidant capacity in healthy volunteers.
(キーワード): Amino Acids / Antioxidants / Carbohydrates / Cross-Over Studies / Fasting / Humans / Japan / Oxidative Stress / Reactive Oxygen Species
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s00540-017-2355-x
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28421317; ● CiNii @ 国立情報学研究所 (CRID): 1523669554977281152; ● Summary page in Scopus @ Elsevier: 2-s2.0-85017579285

(DOI: 10.1007/s00540-017-2355-x, PubMed: 28421317, CiNii: 1523669554977281152, Elsevier: Scopus) Naoji Mita, Shinji Kawahito, Tomohiro Soga, Tosiko Katayama, Narutomo Wakamatsu, Tomiya Kawahara, Nami Kakuta, Eisuke Hamaguchi, Yasuo Tsutsumi, Katsuya Tanaka, Kazumi Takaishi and Hiroshi Kitahata :
Anesthetic management of a patient with unruptured sinus of valsalva aneurysm with right ventricular outflow tract obstruction.,
Circulation Control, Vol.37, No.3, 195-198, 2016.

(出版サイトへのリンク): ● Publication site (DOI): 10.11312/ccm.37.195
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.11312/ccm.37.195

(DOI: 10.11312/ccm.37.195) Eisuke Hamaguchi, Yasuo Tsutsumi, Katsuyoshi Kume, Yoko Sakai, Nami Kakuta, Yuta Uemura, Shinji Kawahito and Katsuya Tanaka :
General anesthesia of a Japanese infant with Barber-Say syndrome: a case report,
JA Clinical Reports, Vol.2, No.11, 2016.

(徳島大学機関リポジトリ): ● Metadata: 114560
(出版サイトへのリンク): ● Publication site (DOI): 10.1186/s40981-016-0033-x
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29497666; ● Search Scopus @ Elsevier (PMID): 29497666; ● Search Scopus @ Elsevier (DOI): 10.1186/s40981-016-0033-x

(徳島大学機関リポジトリ: 114560, DOI: 10.1186/s40981-016-0033-x, PubMed: 29497666) Takako Kadota, Nami Kakuta, Yousuke T. Horikawa, Rie Tsutsumi, Takuro Oyama, Katsuya Tanaka and Yasuo Tsutsumi :
Plasma substance P concentrations in patients undergoing general anesthesia: an objective marker associated with postoperative nausea and vomiting,
JA Clinical Reports, Vol.2, No.9, 9, 2016.

(要約): This study investigated plasma concentrations of substance P (SP) in patients undergoing general anesthesia (GA) and postoperative nausea and vomiting (PONV). This prospective, observational, cohort study included 23 patients who underwent scheduled surgery under general anesthesia. Blood was collected from the radial artery at predetermined time points (15-30 mins prior anesthesia, 15-30 mins after surgery/GA, and 24 h after surgery). PONV, SP concentrations, risk factors, and analgesics used were measured. Nine of 23 patients experienced PONV. In patients without PONV, SP concentrations significantly decreased ( < 0.0001) at the end of surgery/GA, compared to baseline, and recovered at 24 h after surgery/GA (452.9 ± 146.2 vs. 666.9 ± 176.5 vs. 580.7 ± 168.6 pg/mL, respectively), whereas SP levels were unchanged during surgery/GA and increased at 24 hours after surgery ( = 0.020) in patients with PONV (726.1 ± 167.8 vs. 655.8 ± 168.0 vs. 779.7 ± 220.7 pg/mL, respectively). These finding suggest that SP levels may be utilized as an objective marker for PONV.
(徳島大学機関リポジトリ): ● Metadata: 114557
(出版サイトへのリンク): ● Publication site (DOI): 10.1186/s40981-016-0034-9
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29497664; ● Search Scopus @ Elsevier (PMID): 29497664; ● Search Scopus @ Elsevier (DOI): 10.1186/s40981-016-0034-9

(徳島大学機関リポジトリ: 114557, DOI: 10.1186/s40981-016-0034-9, PubMed: 29497664) Sebe Mayu, Rie Tsutsumi, Yamaguchi Sotaro, Horikawa T. Yousuke, Harada Nagakatsu, Takuro Oyama, Nami Kakuta, Katsuya Tanaka, Yasuo Tsutsumi, Yutaka Nakaya and Hiroshi Sakaue :
The synergistic effects of omega-3 fatty acids against 5-fluorouracil-induced mucosal impairment in mice.,
BMC Nutrition, Vol.2, No.17, 1-10, 2016.

(徳島大学機関リポジトリ): ● Metadata: 114371
(出版サイトへのリンク): ● Publication site (DOI): 10.1186/s40795-016-0057-7
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1186/s40795-016-0057-7

(徳島大学機関リポジトリ: 114371, DOI: 10.1186/s40795-016-0057-7) Nami Kakuta, Shinji Kawahito, Naoji Mita, Tomohiro Soga, Toshiko Katayama, Kohei Fukuta, Hiroaki Kawano, Fumihiko Tada, Yasuo M. Tsutsumi, Katsuya Tanaka, Kazumi Takaishi and Hiroshi Kitahata :
Role of transesophageal echocardiography during biventricular pacemaker implantation in children,
Clinical Pediatric Anesthesia, Vol.21, 182-185, 2015. Tomohiro Soga, Katsuyoshi Kume, Nami Kakuta, Eisuke Hamaguchi, Rie Tsutsumi, Ryosuke Kawanishi, Kohei Fukuta, Katsuya Tanaka and Yasuo M. Tsutsumi :
Fosaprepitant versus ondansetron for the prevention of postoperative nausea and vomiting in patients who undergo gynecologic abdominal surgery with patient-controlled epidural analgesia: a prospective, randomized, double-blind study.,
Journal of Anesthesia, Vol.29, No.5, 696-701, 2015.

(要約): No (0 %) patient in the NKI group experienced vomiting after surgery; however, 4-6 (20-30 %) of 20 patients in the ONS group experienced vomiting. This difference was significant at 0-24, 0-48, and 0-72 h. During the study period, no significant differences existed between the NK1 and ONS groups in the incidence of PONV, complete response rate, rescue antiemetic use, nausea score, and VAS score for pain.
(徳島大学機関リポジトリ): ● Metadata: 109689
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s00540-015-2006-z
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25801542; ● Summary page in Scopus @ Elsevier: 2-s2.0-84945453279

(徳島大学機関リポジトリ: 109689, DOI: 10.1007/s00540-015-2006-z, PubMed: 25801542, Elsevier: Scopus) Nami Kakuta, Shinji Kawahito, Tomohiro Soga, Naoji Mita, Kouhei Fukuta, Narutomo Wakamatsu, Yoko Sakai, Tosiko Katayama, Fumihiko Tada, Kazumi Takaishi and Hiroshi Kitahata :
Role of an intraoperative single-plane transesophageal echocardiography probe for infants with congenital heart disease,
Clinical Pediatric Anesthesia, Vol.20, No.1, 231-235, 2014. 堤保夫, 堤理恵, 久米克佳, 角田奈美, 山崎理恵, 田中克哉 :
主観的包括的評価(SGA)の結果よりみる周術期栄養状態の実態,
臨床麻酔, Vol.38, No.5, 745-750, 2014年. Nami Kakuta, Shinji Kawahito, Naoji Mita, Noriko Kambe, Asuka Kasai, Narutomo Wakamatsu, Tosiko Katayama, Tomohiro Soga, Fumihiko Tada, Takashi Kitaichi, Tetsuya Kitagawa and Hiroshi Kitahata :
Usefulness of central venous oxygen saturation monitoring during bidirectional Glenn shunt.,
The Journal of Medical Investigation : JMI, Vol.60, No.3, 4, 272-275, 2013.

(要約): A PediaSat™ oximetry catheter (PediaSat: Edwards Lifesciences Co., Ltd., Irvine, CA, U. S. A.), which facilitates continuous measurement of central venous oxygen saturation (ScvO2), may be useful for surgery for pediatric congenital heart disease. We used PediaSat during a bidirectional Glenn shunt. The patient was a 13-month-old boy. Under a diagnosis of left single ventricle (pulmonary atresia, right ventricular hypoplasia, atrial septal defect) and residual left aortic arch/left superior vena cava, a modified right Blalock-Taussig shunt was performed. Cyanosis deteriorated, so a bidirectional Glenn shunt was scheduled. After anesthesia induction, a 4.5 Fr double-lumen (8 cm) PediaSat was inserted through the right internal jugular vein for continuous ScvO2 monitoring. Furthermore, the probe of a near-infrared, mixed blood oxygen saturation-measuring monitor was attached to the forehead for continuous monitoring of the regional brain tissue mixed blood oxygen saturation (rSO2) (INVOS™ 5100C, Covidien; Boulder, CO, U. S. A.). Blockage of the right pulmonary artery and right superior vena cava decreased the oxygen saturation, ScvO2, and rSO2, but increased the central venous pressure. Although changes in ScvO2 were parallel to those in rSO2, the former showed more marked changes. A combination of ScvO2 and rSO2 for monitoring during Glenn shunt may be safer.
(キーワード): Blood Gas Monitoring, Transcutaneous / Catheterization, Central Venous / Fontan Procedure / Heart Defects, Congenital / Heart Ventricles / Humans / Infant / Male / Monitoring, Intraoperative / Oximetry
(徳島大学機関リポジトリ): ● Metadata: 106368
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.60.272
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24190047; ● Summary page in Scopus @ Elsevier: 2-s2.0-84887009442

(徳島大学機関リポジトリ: 106368, DOI: 10.2152/jmi.60.272, PubMed: 24190047, Elsevier: Scopus) Tomohiro Soga, Shinji Kawahito, Nami Kakuta, Tosiko Katayama, Narutomo Wakamatsu, Kazumi Takaishi, Kunihisa Yamaguchi, Hirofumi Izaki, Hiro-omi Kanayama, Hiroshi Kitahata and Shuzo Oshita :
Recent less-invasive circulatory monitoring during renal transplantation.,
The Journal of Medical Investigation : JMI, Vol.60, No.1, 2, 159-163, 2013.

(要約): For anesthetic management during renal transplantation, it is necessary to maintain the blood flow and function of the transplanted kidney by performing massive fluid management and stabilizing blood pressure. We report anesthetic management for renal transplantation with a less-invasive circulatory monitoring system (Edwards Life Sciences Co., Ltd., Irvine, California, U.S.A.). In November 2010, renal transplantation was started in our hospital, and performed in 6 patients. In the first patient, fluid/circulatory management was conducted by connecting a standard arterial line and a standard central venous (CV) line. In the second patient, a FloTrac(TM) system and a standard CV line were used. In the third patient, a standard arterial line and a PreSep(TM) CV Oximetry Catheter were used. In the fourth and fifth patients, a FloTrac(TM) and a PreSep(TM) were used. In the latest patient, FloTrac(TM) and PreSep(TM) were connected to an EV1000(TM) Clinical Platform for fluid/circulatory management. The establishment of high-visibility monitors was useful for evaluating the condition and confirming the effects. As there are marked changes in hemodynamics, the CV pressure, which has been used as a parameter of fluid management, is not reliable in renal failure patients with a high incidence of cardiovascular complications. Advances in noninvasive circulatory monitoring with dynamic indices may improve the safety of anesthetic management during renal transplantation.
(キーワード): Adolescent / Adult / 麻酔 (anesthesia) / Cardiac Output / Central Venous Pressure / Humans / Kidney Transplantation / Middle Aged / Monitoring, Physiologic / Oxygen
(徳島大学機関リポジトリ): ● Metadata: 106058
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.60.159
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23614926; ● CiNii @ 国立情報学研究所 (CRID): 1390282679221800704; ● Summary page in Scopus @ Elsevier: 2-s2.0-84876046292

(徳島大学機関リポジトリ: 106058, DOI: 10.2152/jmi.60.159, PubMed: 23614926, CiNii: 1390282679221800704, Elsevier: Scopus) 大下修弘, 角田奈美, 田中克哉, 濵口英佑, 堤保夫 :
ラリンゴブロック喉頭鏡を使用した気管挿管における有用性の検討,
臨床麻酔, Vol.37, 1225-1227, 2013年. 河野裕明, 河原富也, 角田奈美, 濵口英佑, 堤保夫, 田中克哉, 多田文彦, 大下修造 :
気管分岐部腫瘍に対するレーザー焼灼術の麻酔管理 : レミフェンタニルを用いた自発呼吸温存,
麻酔, Vol.61, No.2, 182-185, 2012年.

(要約): We describe anesthetic management of a patient with airway stenosis due to a tracheal tumor involving the carina. A 68-year-old man developed dyspnea and was scheduled for YAG laser surgery under general anesthesia. Awake fiberoptic intubation was selected for anesthesia induction, and percutaneous cardiopulmonary support (PCPS) was ready to be established prior to induction of anesthesia. Anesthesia was maintained with remifentanil (0.05 microg x kg(-1) x min(-1)) and propofol (2 mg x kg(-1) x hr(-1)), and spontaneous breathing was preserved throughout the surgical procedure. The operation was completed successfully without any adverse events, and PCPS was not used. In this patient, preservation of spontaneous breathing using remifentanil was found to be useful for airway management.
(キーワード): 気管分岐部腫瘍 / 気道狭窄 / 自発呼吸温存 / レミフェンタニル / tracheal tumor involving the carina / airway stenosis / preservation of spontaneous breathing / remifentanil
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22413442; ● CiNii @ 国立情報学研究所 (CRID): 1520290884331590144; ● Summary page in Scopus @ Elsevier: 2-s2.0-84863140669

(PubMed: 22413442, CiNii: 1520290884331590144, Elsevier: Scopus) 富山芳信, 野村佳代, 角田奈美 :
重症筋無力症患者にロクロニウムとスガマデクスを使用した2症例,
日本臨床麻酔学会誌, Vol.31, No.5, 791-797, 2011年.

(キーワード): Myasthenia gravis / Sugammadex / Rocuronium / Thymectomy / Muscle relaxant
(出版サイトへのリンク): ● Publication site (DOI): 10.2199/jjsca.31.791
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1572824499837955968; ● Search Scopus @ Elsevier (DOI): 10.2199/jjsca.31.791

(DOI: 10.2199/jjsca.31.791, CiNii: 1572824499837955968) Nami Kakuta, Yasuo M. Tsutsumi, Yousuke T. Horikawa, Hiroaki Kawano, Michiko Kinoshita, Katsuya Tanaka and Shuzo Oshita :
Neurokinin-1 receptor antagonism, aprepitant, effectively diminishes post-operative nausea and vomiting while increasing analgesic tolerance in laparoscopic gynecological procedures.,
The Journal of Medical Investigation : JMI, Vol.58, No.3-4, 246-251, 2011.

(要約): Post-operative nausea and vomiting (PONV) remains the most frequently reported patient complaint after anesthesia. Aprepitant is the first neurokinin-1(NK1) receptor antagonism available for use as an antiemetic. We investigated whether aprepitant can effectively decrease PONV in patients undergoing laparoscopic gynecological surgery. Sixty four patients receiving general anesthesia for laparoscopic gynecological surgery were randomly assigned to either receive a preoperative dose of 80 mg aprepitant or no drug. Efficacy was assessed in 2 and 24 hours after surgery. Primary and secondary endpoints were analyzed for the time intervals 0-2 hours (acute phase) and 2-24 hours (delayed phase). Vomiting, nausea, use of rescue anti-emetic, and visual analog scale (VAS) were assessed. Nausea was assessed on a 4-point scale, from 0 to 3. Sixty patients participated in the study. At acute phase, PONV was present in both control and NK1 group and were 63% and 43% respectively. The severity of nausea was much less in the NK1 group. PONV prevalence at delayed phase was present in control but absent in NK1 group 27% vs. 0%, respectively. The amount of pain medication used by patients in the NK1 group was significantly less for diclofenac and pentazocine suggesting increase pain tolerance. Neurokinin-1 receptor antagonism effectively lowered PONV increased pain tolerance, and expedited recovery in patients undergoing laparoscopic gynecological surgery.
(キーワード): Adult / Antiemetics / Female / Gynecologic Surgical Procedures / Humans / Laparoscopy / Middle Aged / Morpholines / Pain Measurement / Pain Threshold / Postoperative Nausea and Vomiting / Receptors, Neurokinin-1
(徳島大学機関リポジトリ): ● Metadata: 83838
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.58.246
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21921426; ● Search Scopus @ Elsevier (PMID): 21921426; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.58.246

(徳島大学機関リポジトリ: 83838, DOI: 10.2152/jmi.58.246, PubMed: 21921426) 大下修弘, 富山芳信, 堤保夫, 角田奈美, 曽我朋宏, 井関明生, 大下修造, 田中克哉 :
ベッカー型筋ジストロフィ症患者の麻酔経験,
麻酔, Vol.60, No.8, 950-952, 2011年.

(要約): We experienced anesthetic management of a patient with Becker muscular dystrophy. He had advanced dilated cardiomyopathy and high serum CK in the preoperative examinations. Anesthesia was planned to avoid triggering malignant hyperthermia or rhabdomyolysis and hemodynamic changes. Propofol, remifentanil and a minimum dose of rocuronium bromide were used for anesthetic induction and maintainance. Arterial pressure, cardiac output and stroke volume variation were monitored by Flotrac sensor. There were no adverse events observed during the anesthetic management. In conclusion, total intravenous anesthesia with the administration of rocuronium and circulatory monitoring by Flotrac sensor could be safe and efficient for anesthetic management of patients with Becker muscular dystrophy.
(キーワード): ベッカー型筋ジストロフィ / 拡張型心筋症 / 悪性高熱症 / フロートラックセンサー / ロクロニウム / Becker muscular dystrophy / dilated cardiomyopathy / malignant hyperthermia / Flotrac sensor / rocuronium
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21861423; ● CiNii @ 国立情報学研究所 (CRID): 1520290883351512832; ● Summary page in Scopus @ Elsevier: 2-s2.0-80052046221

(PubMed: 21861423, CiNii: 1520290883351512832, Elsevier: Scopus) Katsuya Tanaka, Takashi Kawano, Yasuo M. Tsutsumi, Michiko Kinoshita, Nami Kakuta, Kayo Hirose, Masakazu Kimura and Shuzo Oshita :
Differential effects of propofol and isoflurane on glucose utilization and insulin secretion.,
Life Sciences, Vol.88, No.1-2, 96-103, 2011.

(要約): Volatile anesthetics, such as isoflurane, reverse glucose-induced inhibition of pancreatic adenosine triphosphate-sensitive potassium (K(ATP)) channel activity, resulting in reduced insulin secretion and impaired glucose tolerance. No previous studies have investigated the effects of intravenous anesthetics, such as propofol, on pancreatic K(ATP) channels. We investigated the cellular mechanisms underlying the effects of isoflurane and propofol on pancreatic K(ATP) channels and insulin secretion.
(キーワード): アデノシン三リン酸 (adenosine triphosphate) / Anesthetics, Inhalation / Anesthetics, Intravenous / Animals / Dose-Response Relationship, Drug / グルコース (glucose) / Glucose Tolerance Test / インスリン (insulin) / Islets of Langerhans / Isoflurane / KATP Channels / 男性 (male) / Membrane Potentials / Patch-Clamp Techniques / Propofol / Rabbits / Rats
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.lfs.2010.10.032
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21056586; ● Summary page in Scopus @ Elsevier: 2-s2.0-78650519087

(DOI: 10.1016/j.lfs.2010.10.032, PubMed: 21056586, Elsevier: Scopus) 大下修弘, 堤保夫, 角田奈美, 河野裕明, 富山芳信, 大下修造 :
クリスタル咽頭鏡ブレードの使用経験,
麻酔, Vol.59, No.6, 802-805, 2010年.

(要約): We evaluated Disposable Crystal Laryngoscope Blades in terms of preventing infection. Most anesthesiologists were satisfied with the view offered by the Disposable Crystal Laryngoscope Blade; however more force is necessary to lift the epiglottis during intubation. It may be more difficult to use by residents, inexperienced anesthesiologist, or emergency medical technicians, although the Disposable Crystal Laryngoscope blade is useful for preventing infection.
(キーワード): 機器の汚染
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20560395; ● CiNii @ 国立情報学研究所 (CRID): 1520853832129832960; ● Summary page in Scopus @ Elsevier: 2-s2.0-77953792110

(PubMed: 20560395, CiNii: 1520853832129832960, Elsevier: Scopus) 大下修弘, 富山芳信, 井関明生, 河野裕明, 角田奈美, 堤保夫, 大下修造 :
Angelman症候群の麻酔経験,
麻酔, Vol.59, No.4, 484-486, 2010年.

(要約): Angelman syndrome is a hereditary disease described by Angelman. The clinical features of Angelman syndrome are characterized by mental retardation, puppet-like ataxia, easily excitable personality, seizures, paroxysmal laughter, strabismus and macroglossia. A 4-year-old girl with Angelman syndrome underwent strabismus repair under general anesthesia. Anesthesia was slowly induced with sevoflurane in oxygen and maintained with air, oxygen, propofol and remifentanil. Tracheal intubation was performed after administration of rocuronium. During and after anesthesia, no adverse events regarding circulatory and respiratory systems occurred. However, this case demonstrates that it is necessary to pay attention to airway troubles including the difficulty of tracheal intubation, management of body temperature and chronotropic action or respiratory depression by anesthetic agents.
(キーワード): *Angelman症候群(合併症)
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20420140; ● CiNii @ 国立情報学研究所 (CRID): 1520290883021246848; ● Summary page in Scopus @ Elsevier: 2-s2.0-77951582562

(PubMed: 20420140, CiNii: 1520290883021246848, Elsevier: Scopus)

MISC

研究者総覧に該当データはありませんでした。

総説・解説

角田奈美, 堤保夫, 田中克哉 :
術後嘔気・嘔吐の最前線,
臨床麻酔, Vol.40, No.4, 573-581, 2016年4月. 門田尚子, 堤保夫, 大下修造, 角田奈美, 田中克哉 :
第5回若手奨励賞受賞論文術後の嘔気・嘔吐--選択的ニューロキニン1受容体拮抗薬が及ぼす影響,
四国医学雑誌, Vol.67, No.3, 143-146, 2011年8月.

(要約): Post-operative nausea and vomiting(PONV)remains the most frequently reported patientscomplaint after anesthesia, and for patients, it is of greater concern than postoperative pain. PONVhas four main risk factors including : female gender, history of PONV or motion sickness, nonsmoking,and the use of postoperative opioids. Primary control of nausea and vomiting arises from the centralpattern generator for vomiting located in the medulla oblongara.Traditionally, the most common anti-emetics used to treat PONV include serotonin 5-hydroxytryptamine type3antagonists such as ondansetron, corticosteroids, like dexamethasone,or droperidol, which is a neuroleptic. However, these anti-emetics are not completely reliable andonly reduce the incidence of PONV by∼26%. Adding additional anti-emetics could further lowerthe incidence of PONV.PONV can result in several post-surgical complications. Neurokinin-1(NK-1)receptors are foundin gastrointenstinal vagal afferents and within the central nervous system vomiting reflex pathways.NK-1receptors are activated by Substance P, which is a regulatory peptide and preferred endogenousligand.We investigated whether NK-1antagonism can effectively diminish PONV in patients undergoinglaparoscopic gynecological surgery. Forty two patients were randomized into two groups : NK-1group which received an oral NK-1antagonist, aprepitant at80mg, and a control that did not receiveany anti-emetic. PONV incidence at2hours was present in both control and NK-1groups and was81% and52%, respectively. At24hours PONV was present in the control group, but was absentin the NK1group(27% and0%，respectively).PONV is associated with dissatisfaction after anesthesia and surgery, can result in several postsurgicalcomplications. NK-1receptor antagonism effectively lowered PONV, and expedited recoveryin patients undergoing laparoscopic gynecological surgery.
(キーワード): post-operative nausea and vomiting / Neurokinin-1 receptor antagonism / aprepitant
(徳島大学機関リポジトリ): ● Metadata: 83819
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1050001337463816448

(徳島大学機関リポジトリ: 83819, CiNii: 1050001337463816448)

講演・発表

Ryo Sekiguchi, Michiko Kinoshita, Ryosuke Kawanishi, Nami Kakuta, Yoko Sakai and Katsuya Tanaka :
Comparison Between Hemodynamics Of Remimazolam And Propofol During General Anesthesia: A Randomized Study,
The Anesthesiology Annual Meeting, Oct. 2022. Yuta Uemura, Nami Kakuta, Ryosuke Kawanishi and Katsuya Tanaka :
Effects of administration based on muscle mass on the onset and duration of action.,
American Society of Anesthesiologists 2019 Annual Meeting, Orlando FL, Oct. 2019. Takuro Oyama, Yuta Uemura, Nami Kakuta, Yasuo Tsutsumi and Katsuya Tanaka :
Glucose transporter-4 mediates acute isoflurane-induced preconditioning in vivo rabbits.,
American Society of Anesthesiologists, San Francisco, Oct. 2018. Asuka Kasai, Kouhei Fukuta, Katsuya Tanaka, Nami Kakuta and Yasuo Tsutsumi :
The effect of intraoperative glucose load on metabolism in patients with diabetes mellitus.,
American Society of Anesthesiologists 2017 Annual Meeting, Oct. 2017. Takuro Oyama, Nami Kakuta, Asuka Kasai, Naoji Mita, Katsuyoshi Kume and Katsuya Tanaka :
Effect of Jelly type carbohydrate on metabolism and evaluation of its excretion in healthy subjects.,
American Society of Anesthesiologists 2017 Annual Meeting, Oct. 2017. Noriko Kambe, Katsuya Tanaka, Nami Kakuta, Yasuo M. Tsutsumi and Shuzo Oshita :
Short-term simvastatin administration in hyperglycemia rabbits facilitate anesthetic postconditioning.,
The American Society of Anesthesiologist Annual Meeting, San Francisco, Oct. 2013. Naoji Mita, Shinji Kawahito, Nami Kakuta, 久米克佳, Kazumi Takaishi and Hiroshi Kitahata :
Continuous blood glucose monitoring during cardiopulmonary bypass for children.,
The Annual Meeting of the American Society of Anesthesiologists, San Francisco, Oct. 2013. Naoji Mita, Shinji Kawahito, Nami Kakuta, Katsuyoshi Kume, Kazumi Takaishi and Hiroshi Kitahata :
Intraoperative application of the artificial endocrine pancreas.,
The Annual Meeting of the American Society of Anesthesiologists, San Francisco, Oct. 2013. Shinji Kawahito, Naoji Mita, Nami Kakuta, Kazumi Takaishi and Hiroshi Kitahata :
Intensive insulin therapy using an artificial pancreas during liver transplantation., --- Symposium: Artificial Pancreas: What is more sophisticated glycemic control? ---,
5th Congress of the International Federation for Artificial Organs (IFAO 2013), Yokohama, Sep. 2013. Yasuo Tsutsumi, Nami Kakuta, Hiroaki Kawano, Katsuya Tanaka and Shuzo Oshita :
Neurokinin-1 receptor antagonism effectively diminishes post-operative nausea and vomiting while increasing analgesic tolerance in laparoscopic gynecological procedures.,
American Society of Anesthesiologists 2011 Annual Meeting, Chicago, Oct. 2011. 岩朝一馬, 川西良典, 角田奈美, 田中克哉 :
高齢肺がん患者で右中葉下葉切除術後の左下葉部分切除術に対して左下葉の選択的ブロックを行った症例の麻酔経験第36回日本老年麻酔学会,
2024年2月. 前田悠樹, 角田奈美, 米澤宏記, 田中克哉 :
心室中隔欠損パッチ閉鎖術+supramitral ring切除の術中TEEで左心耳翻転が認められた一例日本小児麻酔学会第28回大会,
2023年10月. 米澤宏記, 角田奈美, 関口諒, 田中克哉 :
Fallot四徴症術後のPVR術中に発症した特発性冠動脈解離の診断に術野冠動脈エコーが有用だった一例,
2023年9月. 高橋里加子, 川西良典, 角田奈美, 田中克哉 :
2回目の迷走神経刺激術時にテスト刺激により心停止を伴う高度な徐脈を認めた症例第44回日本循環制御医学会,
2023年7月. 前田悠樹, 角田奈美, 笠井飛鳥, 川西良典, 田中克哉 :
Eisenmenger症候群患者の腹腔鏡下子宮全摘術の麻酔経験第44回日本循環制御医学会,
2023年7月. 曽我部洋平, 角田奈美, 川西良典, 田中克哉 :
有茎性振り子状の声帯腫瘍の喉頭微細手術に対して高頻度ジェット換気を使用した麻酔経験第35回日本老年麻酔学会,
2023年3月. 角田奈美, 米澤宏記, 酒井陽子, 村上千晶, 田中克哉 :
超高齢者(102歳)重症大動脈弁狭窄患者に麻酔導入薬としてレミマゾラムを使用した症例第27回日本心臓血管麻酔学会学術集会,
2022年9月. 高橋里加子, 武藤さら良, 松田みゆき, 木下倫子, 角田奈美, 田中克哉 :
修正型電気けいれん療法(mECT)誘発性たこつぼ型心筋症の再発予防のための麻酔管理:症例報告と文献レビュー,
日本麻酔科学会中国・四国支部第59回学術集会, 2022年. 本多康人, 石川雄樹, 角田奈美, 田中克哉 :
全身麻酔下での径カテーテル的大動脈弁置換術(TAVI)直後の脳梗塞発症に対し血栓回収療法にて治療しえた高齢者の一例,
第32回日本老年麻酔学会, 2020年2月. 植村勇太, 堤保夫, 角田奈美, 田中克哉 :
メチルマロン酸血症患者に対する連続携行式腹膜灌流用カテーテル腹腔内留置術の麻酔経験,
日本臨床麻酔学会第38回大会, 2018年11月. 角田奈美, 大山拓朗, 村上千晶, 里見志帆, 酒井陽子, 田中克哉 :
49年前に施行された閉鎖式交連切開術後，左室仮性瘤を生じ長期経過していた一例,
日本心臓血管麻酔学会第23回学術大会, 2018年9月. 大西亜里香, 川西良典, 角田奈美, 里見志帆, 酒井陽子, 田中克哉 :
マクロクレアチニンキナーゼ血症を合併した開腹結腸悪性腫瘍切除術の麻酔経験,
日本麻酔科学会中国四国支部第55回学術集会, 2018年9月. 内藤茂之, 川西良典, 角田奈美, 堤保夫, 田中克哉 :
マスク換気時に胃内への空気流入が起こる最小の吸気圧の検討,
日本麻酔科学会中国四国支部第55回学術集会, 2018年9月. 川西良典, 石川雄樹, 大山拓朗, 角田奈美, 田中克哉 :
マスク換気時の上気道狭窄部位の同定，咽頭狭窄のリスク因子の検討,
日本麻酔科学会第65回学術集会, 2018年5月. 植村勇太, 角田奈美, 田中克哉 :
TOF-cuff筋弛緩モニタを用いて術中全身管理を行った高齢者の手術症例,
第30回日本老年麻酔学会, 2018年2月. 大山拓朗, 堤保夫, 角田奈美, 田中克哉 :
炭水化物含有ゼリータイプ経口補水液の胃排出と代謝に与える影響,
日本臨床麻酔学会第37回大会, 2017年11月. 濵口英佑, 角田奈美, 里見志帆, 大山拓朗, 川人伸次, 田中克哉 :
僧帽弁機械弁置換術後の帝王切開術の麻酔経験,
日本心臓血管麻酔学会第22回学術大会, 2017年9月. 布村俊之, 酒井陽子, 濵口英佑, 角田奈美, 田中克哉 :
長時間砕石位で下腿コンパートメント症候群を来した一症例,
日本麻酔科学会中国・四国第54回学術集会, 2017年9月. 吉田佳子, 川西良典, 角田奈美, 堤保夫, 田中克哉 :
スリップジョイントからのfogartyカテーテルの挿入・固定で安定した分離肺換気を施行下新生児の一例,
本麻酔科学会中国・四国第54回学術集会, 2017年9月. 小松里帆, 川西良典, 箕田直治, 角田奈美, 田中克哉 :
マスク換気困難のリスク因子および咽頭狭窄のリスク因子の検討,
日本麻酔科学会中国・四国第54回学術集会, 2017年9月. 角田奈美, 堤保夫, 田中克哉, 川西良典 :
救急救命士の喉頭鏡を用いた気管挿管の成功率,
第42回日本外科系連合学術集会, 2017年6月. 角田奈美, 里見志帆, 堤保夫, 田中克哉 :
帝王切開術における硬膜外麻酔の間歇ボーラス投与と持続投与での術後鎮痛に関する研究,
日本麻酔科学会第64回学術集会, 2017年6月. 笠井飛鳥, 福田浩平, 角田奈美, 堤保夫, 田中克哉 :
糖尿病患者におけるレミフェンタニル麻酔と糖負荷が代謝に与える影響,
日本麻酔科学会第64回学術集会, 2017年6月. 大山拓朗, 堤保夫, 箕田直治, 角田奈美, 田中克哉 :
ゼリータイプ経口補水液を用いた炭水化物負荷が酸化ストレスに与える影響,
日本麻酔科学会第64回学術集会, 2017年6月. 張雄紀, 箕田直治, 角田奈美, 堤保夫, 田中克哉 :
290回の修正電気けいれん療法を行った一例,
日本麻酔科学会中国・四国支部第53回学術集会, 2016年9月. 箕田直治, 川人伸次, 濵口英佑, 角田奈美, 田中克哉, 北畑洋 :
心臓血管外科手術中の血糖値連続モニタリングシステムの制度,
日本心臓血管麻酔学会第20回学術大会, 2015年10月. 角田奈美, 川人伸次, 箕田直治, 曽我朋宏, 片山俊子, 多田文彦, 堤保夫, 田中克哉, 高石和美, 北畑洋 :
小児体外循環中の血糖値連続モニタリングの精度,
日本小児麻酔学会第21回大会, 2015年8月. 角田奈美, 濵口英佑, 曽我朋弘, 河原富也, 小居理恵, 田中克哉, 堤保夫 :
周術期の血漿サブスタンスP濃度の推移と術後嘔気・嘔吐(postoperativr nausea and vomiting: PONV)の関連,
日本臨床麻酔学会第34回大会, 2014年11月. 濵口英佑, 角田奈美, 福田浩平, 曽我朋弘, 久米克佳, 植村勇太, 田中克哉, 堤保夫 :
下肢人工関節置換術における術後悪心・嘔吐予防のランダム化試験,
日本臨床麻酔学会第34回大会, 2014年11月. 堤保夫, 濵口英佑, 福田浩平, 河原富也, 中路佳美, 植村勇太, 角田奈美, 田中克哉 :
術前炭水化物負荷による手術室搬入時の飢餓抑制効果,
日本臨床麻酔学会第34回大会, 2014年11月. 川西良典, 中路佳美, 神邊紀子, 角田奈美, 堤保夫, 田中克哉 :
血管透見モデルを用いた研修医による動脈穿刺法の比較,
第61回日本麻酔科学会学術集会, 2014年5月. 堤保夫, 角田奈美, 久米克佳, 曽我朋宏, 川西良典, 田中克哉 :
脳神経外科開頭手術後の嘔気・嘔吐に対するニューロキニン1受容体拮抗剤とオンダンセトロンの有効性の比較検討,
第61回日本麻酔科学会, 2014年5月. 角田奈美, 田中克哉, 久米克佳, 濵口英佑, 河原富也, 中路佳美, 東島祥代, 堤保夫 :
救急救命士による気管挿管の成功率,
第33回臨床麻酔学会, 2013年11月. 久米克佳, 曽我朋宏, 濵口英佑, 田中克哉, 河原富也, 東島祥代, 角田奈美, 堤保夫 :
脳神経外科手術後の嘔気・嘔吐に対するニューロキニン1受容体拮抗剤の有効性,
第33回臨床麻酔学会, 2013年11月. 箕田直治, 川人伸次, 久米克佳, 角田奈美, 北畑洋 :
右室流出路狭窄を伴う非破裂性右Valsalva洞動脈瘤の1症例,
日本心臓血管麻酔学会第18回学術集会, 2013年9月. 田中克哉, 角田奈美, 堤保夫 :
PONVの薬物療法,
第11回周術期体液・代謝・侵襲研究会, 2013年8月. 堤保夫, 大下修造, 角田奈美, 曽我朋宏, 田中克哉 :
PONVの薬物療法―NK1受容体拮抗剤を使用した臨床研究―,
第60回日本麻酔科学会, 2013年5月. 神邊紀子, 田中克哉, 角田奈美, 堤保夫, 曽我朋宏, 大下修造 :
手術中の糖負荷はレミフェンタニル麻酔中の脂肪異化を抑制する,
第60回日本麻酔科学会, 2013年5月. 堤保夫, 曽我朋宏, 角田奈美, 神邊紀子, 田中克哉, 大下修造 :
ピーリング・ラリンジアルマスクを用いた気管挿管方法の検討,
第60回日本麻酔科学会, 2013年5月. 箕田直治, 川人伸次, 角田奈美, 北畑洋, 大下修造 :
血糖値連続モニタリング・コントロールシステムの術中適応-各種術式の典型的血糖値変動を中心に-,
日本麻酔科学会第59回学術集会, 2012年6月. 若松成知, 箕田直治, 角田奈美, 川人伸次 :
原因不明のrSO2低下に対し，頭側に小児用CVオキシメトリカテーテルを挿入して管理を行った一症例,
日本臨床麻酔学会誌, Vol.31, No.6, s485, 2011年11月. 門田尚子, 堤保夫, 大下修造, 河野裕明, 笠井飛鳥, 木下倫子, 角田奈美, 田中克哉 :
術後嘔気・嘔吐に対する選択的ニューロキニン1受容体拮抗薬の有効性,
日本臨床麻酔学会第31回大会, 2011年11月. 角田奈美, 門田尚子, 田中克哉, 堤保夫, 曽我朋宏, 髙田香, 富山芳信, 大下修造 :
食道癌により食道気管廔を形成した患者に右用ダブルルーメンチューブを用いて麻酔管理をした一症例,
日本臨床麻酔学会第31回大会, 2011年11月. 角田奈美, 堤保夫, 木下倫子, 田中克哉, 河野裕明, 大下修造, 大下修造 :
選択的ニューロキニン1受容体拮抗型制吐剤が術後嘔気嘔吐に及ぼす影響,
日本麻酔科学会第58回学術集会, 2011年5月. 富山芳信, 野村佳世, 角田奈美, 大下修造 :
重症筋無力症に，ロクロニウムとスガマデクスを使用した症例,
日本臨床麻酔学会第30回大会, 2010年11月. 河原富也, 河野裕明, 角田奈美, 田中克哉, 大下修造 :
気管分岐部腫瘍により気道狭窄を来した症例の麻酔経験,
日本臨床麻酔学会第30回大会徳島, 2010年11月. 堤保夫, 廣瀬佳代, 木下倫子, 角田奈美, 田中克哉, 大下修造 :
吸入麻酔薬による遅延型プレコンディショニングの細胞膜ドメインに及ぼす影響,
第57回日本麻酔科学会, 2010年6月. 廣瀬佳代, 堤保夫, 角田奈美, 松岡祥代, 田中克哉, 大下修造 :
イソフルランによる心筋保護効果におけるO-Linkedβ-N-Acetylglucosamineの役割,
第57回日本麻酔科学会, 2010年6月. 角田奈美, 田中克哉, 木下倫子, 河野崇, 堤保夫, 大下修造 :
プロポフォールとイソフルランがブドウ糖負荷試験に及ぼす影響,
第57回日本麻酔科学会, 2010年6月.

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補助金・競争的資金: 吸入麻酔薬のSirtを介した心筋保護作用に対して高血糖状態が与える影響 (研究課題/領域番号: 22K09048 )
吸入麻酔薬の心筋保護作用―サーチュインとミトコンドリア機能調節の役割― (研究課題/領域番号: 18K16483 )
吸入麻酔薬の心保護作用に対するオートファジー・ミトコンドリアダイナミックスの影響 (研究課題/領域番号: 18K08817 )
吸入麻酔薬の心筋保護作用がミトコンドリアダイナミクスに与える影響 (研究課題/領域番号: 17K16735 )
吸入麻酔薬とGLP-1の心筋保護相互作用―ミトコンドリア機能に与える影響― (研究課題/領域番号: 17K16734 )
代謝モニターを用いた周術期栄養管理とその効果の検討 (研究課題/領域番号: 24791598 )
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2024年11月15日更新

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2024年11月9日更新

研究者番号: 00622606

所属（現在）: 2024/4/1 : 徳島大学, 大学院医歯薬学研究部(医学域), 准教授

所属（過去の研究課題 情報に基づく）*注記: 2022/4/1 : 徳島大学, 大学院医歯薬学研究部(医学域), 准教授
2019/4/1 – 2020/4/1 : 徳島大学, 大学院医歯薬学研究部(医学域), 講師
2018/4/1 : 徳島大学, 病院, 講師
2012/4/1 – 2013/4/1 : 徳島大学, 大学病院, 助教

審査区分/研究分野

研究代表者

生物系 / 医歯薬学 / 外科系臨床医学 / 麻酔・蘇生学
小区分55050:麻酔科学関連

研究代表者以外

生物系 / 医歯薬学 / 外科系臨床医学 / 麻酔科学
小区分55050:麻酔科学関連

キーワード

研究代表者

術前補水 / 術中輸液 / 術後栄養 / 代謝モニター / 消費エネルギー / 呼吸商 / 周術期栄養管理 / 消費エネルギー量 / ERAS / 経口補水液 / サーチュイン / イソフルラン / 吸入麻酔薬 / 心筋保護 / 虚血再灌流障害 / プレコンディショニング / ミトコンドリア / ミトコンドリア機能 / Sirt / 高血糖

研究代表者以外

オートファジー / イソフルラン / 吸入麻酔薬 / 心筋保護 / 虚血再灌流障害 / エネルギー代謝 / ミトコンドリア / プレコンディショニング / 心筋保護作用 / ミトコンドリア機能 / 虚血再灌流実験 / GLP-1 / Opa-1

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角田 奈美

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研究代表者

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角田奈美