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江川麻理子

徳島大学

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2024年12月20日更新

職名: 講師
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学歴: 1997/3: 徳島大学大学院医学研究科博士課程修了
学位: 博士(医学) (徳島大学) (1997年3月)
職歴・経歴: 2005/4: 徳島大学非常勤講師, 医学部 (-2006.3.)
2008/1: 徳島大学助教, 大学院ヘルスバイオサイエンス研究部 (-2015.3.)
2015/4: 徳島大学助教, 大学院医歯薬学研究部 (-2015.4.)
2015/5: 徳島大学講師, 大学院医歯薬学研究部 (-2024.3.)
2024/4: 徳島大学講師, 病院

専門分野・研究分野: 医学 (Medicine)

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2024年12月20日更新

専門分野・研究分野: 医学 (Medicine)
担当経験のある授業科目: 皮膚・感覚器コース (学部)
眼科学(隣接医学A) (学部)
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研究者総覧で最新データを確認する

2024年12月20日更新

専門分野・研究分野: 医学 (Medicine)

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著書

江川麻理子 :
今日の眼疾患治療指針第4版強皮症,
医学書院, 東京, 2022年9月.

論文

Hirotaka Yokouchi, Daisuke Nagasato, Yoshinori Mitamura, Mariko Egawa, Hitoshi Tabuchi, Sonoko Misawa, Satoshi Kuwabara and Takayuki Baba :
Alterations in choroidal vascular structures due to serum levels of vascular endothelial growth factor in patients with POEMS syndrome.,
Scientific Reports, Vol.13, No.1, 2023.

(要約): A higher serum vascular endothelial growth factor (VEGF) level can cause choroidal thickening in the choroid of patients with polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome. We aimed to determine whether fluctuations in serum VEGF levels affect choroidal vascular structures in patients with POEMS syndrome. This retrospective observational case series examined 17 left eyes of 17 patients with POEMS syndrome. Enhanced depth imaging optical coherence tomography (EDI-OCT) images were obtained, and serum VEGF levels were measured at baseline and 6 months after transplantation with dexamethasone (n = 6), thalidomide (n = 8), or lenalidomide (n = 3). EDI-OCT images were binarized using ImageJ software, and we calculated the areas of the whole choroid and the luminal and stromal areas. Subsequently, we determined whether the choroidal vascular structure had changed significantly between baseline and 6 months after treatment. Six months after treatment, serum VEGF levels and the whole choroid, luminal, and stromal areas had decreased significantly compared to the baseline values (all, P < 0.001). The mean luminal area to the whole choroidal area ratio at 6 months after treatment was 0.70 ± 0.03, which was significantly smaller than the ratio at baseline (0.72 ± 0.03; P < 0.001). Whole choroid and luminal area fluctuations were significantly positively correlated with fluctuations in serum VEGF levels (r = 0.626, P = 0.007 and r = 0.585, P = 0.014, respectively). Choroidal thickening induced by VEGF might be caused by increases in the choroidal vessel lumen area. These results may offer insights into the pathogenesis of POEMS syndrome and the role of serum VEGF in choroidal vascular structure, which may apply to other ocular diseases.
(キーワード): Humans / POEMS Syndrome / Vascular Endothelial Growth Factor A / Retrospective Studies / Choroid / Monoclonal Gammopathy of Undetermined Significance
(徳島大学機関リポジトリ): ● Metadata: 119451
(出版サイトへのリンク): ● Publication site (DOI): 10.1038/s41598-023-37727-4
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37391497; ● Search Scopus @ Elsevier (PMID): 37391497; ● Search Scopus @ Elsevier (DOI): 10.1038/s41598-023-37727-4

(徳島大学機関リポジトリ: 119451, DOI: 10.1038/s41598-023-37727-4, PubMed: 37391497) Daisuke Nagasato, Takahiro Sogawa, Mao Tanabe, Hitoshi Tabuchi, Shogo Numa, Akio Oishi, Hanako Ikeda Ohashi, Akitaka Tsujikawa, Tadao Maeda, Masayo Takahashi, Nana Ito, Gen Miura, Terumi Shinohara, Mariko Egawa and Yoshinori Mitamura :
Estimation of Visual Function Using Deep Learning From Ultra-Widefield Fundus Images of Eyes With Retinitis Pigmentosa.,
JAMA Ophthalmology, Vol.141, No.4, 305-313, 2023.

(要約): The study included 1274 eyes of 695 patients. A total of 385 patients were female (55.4%), and the mean (SD) age was 53.9 (17.2) years. Among the 3 types of images, the model using ultra-widefield fundus autofluorescence images alone provided the best estimation accuracy for mean deviation, central sensitivity, and visual acuity. Standardized regression coefficients were 0.684 (95% CI, 0.567-0.802) for the mean deviation estimation, 0.697 (95% CI, 0.590-0.804) for the central sensitivity estimation, and 0.309 (95% CI, 0.187-0.430) for the visual acuity estimation (all P < .001).
(キーワード): Humans / Female / Middle Aged / Male / Retrospective Studies / Artificial Intelligence / Cross-Sectional Studies / Deep Learning / Fluorescein Angiography / Tomography, Optical Coherence / Retinitis Pigmentosa / Fundus Oculi
(出版サイトへのリンク): ● Publication site (DOI): 10.1001/jamaophthalmol.2022.6393
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36821134; ● Search Scopus @ Elsevier (PMID): 36821134; ● Search Scopus @ Elsevier (DOI): 10.1001/jamaophthalmol.2022.6393

(DOI: 10.1001/jamaophthalmol.2022.6393, PubMed: 36821134) Keisuke Minami, Mariko Egawa, Keisuke Kajita, Fumiko Murao and Yoshinori Mitamura :
A Case of Vogt-Koyanagi-Harada Disease-Like Uveitis Induced by Nivolumab and Ipilimumab Combination Therapy.,
Case Reports in Ophthalmology, Vol.12, No.3, 952-960, 2021.

(要約): Nivolumab and ipilimumab are widely used immune checkpoint inhibitors (ICPIs) for the treatment of metastatic melanoma. ICPIs cause an array of side effects called immune-related adverse events (IRAEs) due to activation of an immune response. ICPI-uveitis can cause irreversible vision loss if untreated. There are few reports of recurrent Vogt-Koyanagi-Harada (VKH) disease-like uveitis induced by nivolumab and ipilimumab. We report a case of VKH disease-like uveitis recurrence after resuming ICPIs. A 73-year-old man with advanced melanoma was referred to our clinic with visual loss 25 days after starting nivolumab/ipilimumab. His corrected visual acuity was 0.5 in the right eye and 0.02 in the left eye. Enhanced-depth imaging optical coherence tomography (EDI-OCT) showed marked choroid thickening. The patient was diagnosed with VKH disease-like uveitis due to IRAEs. Subtenon injection of triamcinolone acetonide was performed, and nivolumab/ipilimumab was suspended, but serous retinal detachment (SRD) markedly worsened and choroidal detachment appeared. With 2 courses of steroid pulse therapy and oral steroids, SRD disappeared, and corrected visual acuity recovered in both eyes. Five months after the first injection, exacerbation of melanoma was observed, and nivolumab and oral steroids were restarted. Six weeks later, an increase in choroidal thickness was observed with EDI-OCT and diagnosed as a recurrence of VKH disease-like uveitis. Monitoring for the recurrence of VKH disease-like uveitis during the administration of ICPIs, even after uveitis is treated, is essential. Assessment of choroidal thickness with EDI-OCT may be useful for detecting early signs of VKH disease-like uveitis.
(徳島大学機関リポジトリ): ● Metadata: 117306
(出版サイトへのリンク): ● Publication site (DOI): 10.1159/000520416
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35082654; ● Search Scopus @ Elsevier (PMID): 35082654; ● Search Scopus @ Elsevier (DOI): 10.1159/000520416

(徳島大学機関リポジトリ: 117306, DOI: 10.1159/000520416, PubMed: 35082654) 森木冠奈, 三田村佳典, 江川麻理子 :
強皮症による偽性腸閉塞からビタミンA欠乏性夜盲となった1例,
臨床眼科, Vol.75, No.9, 1213-1220, 2021年.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1521699231174835328

(CiNii: 1521699231174835328) Yoshinori Mitamura, Tserennadmid Enkhmaa, Hiroki Sano, Masanori Niki, Fumiko Murao, Mariko Egawa, Shozo Sonoda and Taiji Sakamoto :
Changes in choroidal structure following intravitreal aflibercept therapy for retinal vein occlusion.,
The British journal of Ophthalmology, Vol.105, No.5, 704-710, 2021.

(要約): RVO induces substantial oedema of the choroidal stromal area that is detectable by binarisation of EDI-OCT images. This stromal oedema likely stems from high intraocular vascular endothelial growth factor levels. Changes in choroidal structure may be used to assess severity and prognosis of RVO.
(キーワード): Adult / Aged / Aged, 80 and over / Angiogenesis Inhibitors / Choroid / Female / Fluorescein Angiography / Fundus Oculi / Humans / Intravitreal Injections / Male / Middle Aged / Receptors, Vascular Endothelial Growth Factor / Recombinant Fusion Proteins / Retinal Vein Occlusion / Retrospective Studies / Tomography, Optical Coherence / Treatment Outcome / Vascular Endothelial Growth Factor A / Visual Acuity
(徳島大学機関リポジトリ): ● Metadata: 117304
(出版サイトへのリンク): ● Publication site (DOI): 10.1136/bjophthalmol-2020-316214
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32620686; ● Search Scopus @ Elsevier (PMID): 32620686; ● Search Scopus @ Elsevier (DOI): 10.1136/bjophthalmol-2020-316214

(徳島大学機関リポジトリ: 117304, DOI: 10.1136/bjophthalmol-2020-316214, PubMed: 32620686) Daisuke Nagasato, Yoshinori Mitamura, Mariko Egawa, Fumiko Murao, Toshihiko Nagasawa, Natsumi Komori, Shozo Sonoda, Taiji Sakamoto and Hitoshi Tabuchi :
Changes in Choroidal Component Ratio and Circulation After Coffee Intake in Healthy Subjects.,
Investigative Ophthalmology & Visual Science, Vol.62, No.3, 2021.

(要約): Coffee-induced choroidal thinning may result mainly from a reduction in the choroidal vessel lumen, and this vessel lumen reduction correlated with an increased choroidal blood flow velocity after coffee intake. These coffee-induced changes in choroidal component ratio and circulation should be considered when evaluating choroids.
(キーワード): Adult / Blood Circulation / Blood Flow Velocity / Choroid / Coffee / Cross-Sectional Studies / Female / Healthy Volunteers / Hemodynamics / Humans / Intraocular Pressure / Male / Prospective Studies / Regional Blood Flow / Tomography, Optical Coherence / Young Adult
(徳島大学機関リポジトリ): ● Metadata: 117320
(出版サイトへのリンク): ● Publication site (DOI): 10.1167/iovs.62.3.27
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33735377; ● Search Scopus @ Elsevier (PMID): 33735377; ● Search Scopus @ Elsevier (DOI): 10.1167/iovs.62.3.27

(徳島大学機関リポジトリ: 117320, DOI: 10.1167/iovs.62.3.27, PubMed: 33735377) Mariko Egawa, Yoshinori Mitamura, Masanori Niki, Hiroki Sano, Gen Miura, Akihiro Chiba, Shuichi Yamamoto, Shozo Sonoda and Taiji Sakamoto :
CORRELATIONS BETWEEN CHOROIDAL STRUCTURES AND VISUAL FUNCTIONS IN EYES WITH RETINITIS PIGMENTOSA,
Retina, Vol.39, No.12, 2399-2409, 2019.

(要約): To investigate the choroidal structures in the enhanced depth imaging optical coherence tomographic images in eyes with retinitis pigmentosa (RP) and to determine correlations between the choroidal structures and visual functions. The enhanced depth imaging optical coherence tomographic images of 100 eyes with typical RP and 60 age-, sex-, and axial length-matched normal eyes were binarized using ImageJ. The cross-sectional luminal and stromal areas of the inner and outer subfoveal choroid of 1,500-µm width were measured. The inner choroid included the choriocapillaris and medium vessel layer, and the outer choroid included the larger vessel layer. In the inner choroid, the luminal area and the ratio of luminal/total choroidal area (L/C ratio) were significantly smaller in RP than in controls (P = 0.010, P < 0.001, respectively), whereas the stromal area was not significantly different (P = 0.114). The inner choroidal L/C ratio was significantly correlated with the best-corrected visual acuity, mean deviation, foveal sensitivity, width of the ellipsoid zone, and central foveal thickness in RP after adjusting for the axial length, age, and sex (all P < 0.005). The significant correlations between the inner choroidal structures and the visual functions and retinal structures indicate that the choroidal structures are altered in association with the progression of RP.This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
(徳島大学機関リポジトリ): ● Metadata: 116469
(出版サイトへのリンク): ● Publication site (DOI): 10.1097/IAE.0000000000002285
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30106795; ● Search Scopus @ Elsevier (PMID): 30106795; ● Search Scopus @ Elsevier (DOI): 10.1097/IAE.0000000000002285

(徳島大学機関リポジトリ: 116469, DOI: 10.1097/IAE.0000000000002285, PubMed: 30106795) 梶田敬介, 江川麻理子, 三田村佳典 :
ぶどう膜炎の黄斑浮腫に対してメトトレキサート硝子体注射を行った2症例,
臨床眼科, Vol.73, No.10, 1319-1326, 2019年.

(出版サイトへのリンク): ● Publication site (DOI): 10.11477/mf.1410213295
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.11477/mf.1410213295

(DOI: 10.11477/mf.1410213295) Naoko Kakiuchi, Shozo Sonoda, Hiroto Terasaki, Hideki Shiihara, Mariko Egawa, Yoshinori Mitamura and Taiji Sakamoto :
Choroidal vasculature from ultra-widefield images without contrast dye and its Application to Vogt-Koyanagi-Harada Disease,
Ophthalmology. Retina, Vol.3, No.2, 161-169, 2019.

(要約): To develop a method to obtain ultra-widefield choroidal vessel images with a fundus camera without using dye, and its application in Vogt-Koyanagi-Harada (VKH) disease. Experimental study and case series. Patients with unilateral retinal disorders and those with VKH disease who had undergone ultra-widefield imaging were studied. Indocyanine green angiography (ICGA) and the 635-nm wavelength Optos ultra-widefield fundus photography (Optos, United Kingdom) images (Optos) were processed by KagoEye 3 software. The 2 types of images were overlapped. The degree of overlapped blood vessel areas of the ICGA image was taken as the matching ratio. The matching ratio was obtained for the peripheral, posterior pole, and overall areas. In addition, changes in the fundus findings were followed up with Optos image analysis in patients with VKH disease. The degree of visibility of the choroidal vessels was evaluated for 5 stages. The clarity scores and the longitudinal findings were compared. The matching ratios between the ICGA images and the Optos images processed by KagoEye3 software were determined. Initially, 10 healthy eyes were studied. The matching ratios for the overall area, the peripheral area, and the posterior pole area of the ICGA image and the Optos image were 64.09%, 74%, and 63.10%, respectively. The correlations between the choroidal blood vessel matching ratio and the ocular axial length and refractive error were not significant, but the matching ratio was correlated significantly with the age. The average clarity score in 12 VKH disease patients was 1.6 ± 0.85 before treatment, which was significantly improved to 4.2 ± 0.75 after 1 month (P < 0.05). Many hyporeflective spotty lesions were observed on the Optos images, which coincided with hyperfluorescent dots on the ICGA images. The lesions gradually disappeared and the vortex vein became visible after treatment. The ultra-widefield Optos images processed by KagoEye3 software can exaggerate images of the choroidal vessels in widefield fundus images without using dye. Because this method is noninvasive, it is applicable to a variety of diseased and healthy eyes.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.oret.2018.09.005
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31014767; ● Summary page in Scopus @ Elsevier: 2-s2.0-85070435445

(DOI: 10.1016/j.oret.2018.09.005, PubMed: 31014767, Elsevier: Scopus) 藤本智子, 宮本龍郎, 江川麻理子, 三田村佳典 :
遠視化をきたしたビスホスホネート製剤によるぶどう膜炎と眼窩内炎症の1例,
臨床眼科, Vol.72, No.7, 989-995, 2018年.

(出版サイトへのリンク): ● Publication site (DOI): 10.11477/mf.1410212755
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.11477/mf.1410212755

(DOI: 10.11477/mf.1410212755) 森輝実, 宮本龍郎, 江川麻理子, 三田村佳典, 市原裕子, 岡村和美, 渡邊浩良 :
両眼性の漿液性網膜剥離をきたした急性リンパ性白血病の1例,
臨床眼科, Vol.71, No.6, 905-912, 2017年.

(出版サイトへのリンク): ● Publication site (DOI): 10.11477/mf.1410212302
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390002209944414976; ● Search Scopus @ Elsevier (DOI): 10.11477/mf.1410212302

(DOI: 10.11477/mf.1410212302, CiNii: 1390002209944414976) 岩田明子, 四宮加容, 大串陽子, 江川麻理子, 三田村佳典 :
徳島大学病院における未熟児網膜症の検討,
眼科臨床紀要, Vol.10, No.6, 486-489, 2017年.

(キーワード): 未熟児網膜症 / 出生時在胎週数 / 出生時体重 / 酸素投与日数
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1520854806143806720; ● Summary page in Scopus @ Elsevier: 2-s2.0-85032813321

(CiNii: 1520854806143806720, Elsevier: Scopus) Takamasa Kinoshita, Yoshinori Mitamura, Kayo Shinomiya, Mariko Egawa, Akiko Iwata, Akiko Fujihara, Kentaro Senba, Yoko Oogushi, Kei Akaiwa, Eisuke Uchino, Taiji Sakamoto and Shozo Sonoda :
Diurnal variations in luminal and stromal areas of choroid in normal eyes,
The British journal of Ophthalmology, Vol.101, No.3, 360-364, 2017.

(要約): To determine the diurnal variations of the luminal and stromal areas of the choroid in normal eyes. This was a prospective observational study of 38 eyes of 38 normal subjects. The blood pressure, heart rate, intraocular pressure and enhanced depth imaging optical coherence tomographic (EDI-OCT) images were recorded every 3 hours between 6:00 and 21:00 hours. The horizontal EDI-OCT images of the subfoveal choroid were converted to binary images. The central choroidal thickness (CCT), total cross-sectional choroidal area, the luminal areas, stromal areas and the ratio of luminal area to total choroidal area (L/C ratio) were determined. There were significant diurnal variations in the CCT, total choroidal area, luminal area and L/C ratio with the maximum values at 6:00 hours and the minimum values at 15:00 hours (p<0.001 for the CCT, p=0.011 for the total choroidal area, p<0.001 for the luminal area and p=0.014 for the L/C ratio). There was no significant variation in the stromal area (p=0.216). The range of fluctuation in the CCT was significantly correlated with that in the luminal area and the total choroidal area (p<0.001). However, there was no significant correlation between the fluctuation range in the CCT and that in the stromal area (p=0.095). There was no statistical relationship between the systemic parameters and the choroidal parameters. The changes in the luminal area are most likely responsible for the diurnal change in the CCT and subfoveal choroidal area. UMIN000019060, Pre-results.
(キーワード): Adult / Choroid / Circadian Rhythm / Cross-Sectional Studies / Female / Humans / Intraocular Pressure / Male / Middle Aged / Prospective Studies / Tomography, Optical Coherence / Young Adult
(出版サイトへのリンク): ● Publication site (DOI): 10.1136/bjophthalmol-2016-308594
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27297216; ● Summary page in Scopus @ Elsevier: 2-s2.0-84979025587

(DOI: 10.1136/bjophthalmol-2016-308594, PubMed: 27297216, Elsevier: Scopus) Erina Daizumoto, Yoshinori Mitamura, Hiroki Sano, Kei Akaiwa, Masanori Niki, Chihiro Yamanaka, Takamasa Kinoshita, Mariko Egawa, Shozo Sonoda and Taiji Sakamoto :
Changes of choroidal structure after intravitreal aflibercept therapy for polypoidal choroidal vasculopathy.,
The British journal of Ophthalmology, Vol.101, No.1, 56-61, 2017.

(要約): To quantify the changes of the choroidal structure in the enhanced depth imaging optical coherence tomographic (EDI-OCT) images after intravitreal aflibercept (IVA) injections for polypoidal choroidal vasculopathy (PCV). Retrospective, observational case series. Forty eyes of 40 treatment-naive patients who underwent IVA for PCV were examined by EDI-OCT before, and 3 months and 12 months after IVA. The EDI-OCT images were binarised by ImageJ software. The cross-sectional luminal and stromal areas of the inner and outer subfoveal choroid of 1500 m width were quantified. The stromal but not the luminal area of the inner choroid was significantly decreased at 3 months and 12 months after the IVA (stromal area, both p<0.001; luminal area, both p>0.050). On the other hand, the luminal but not the stromal area of the outer choroid was significantly decreased at 3 months and 12 months (luminal area, both p<0.001; stromal area, both p>0.050). The Pachychoroid Index, ratio of luminal/stromal area (L/S ratio) of the outer choroid divided by the L/S ratio of the inner choroid, was significantly decreased at 3 months and 12 months (both p<0.050). The Pachychoroid Index was increased and returned almost to the baseline level after recurrences and decreased again after successful re-treatment. The baseline Pachychoroid Index was significantly correlated with the presence of a dry macula, thinner fovea and better visual acuity at 12 months (all p<0.050). The binarisation of the EDI-OCT images can be used to quantify the activity of PCV and to predict the prognosis after IVA.
(キーワード): Aged / Aged, 80 and over / Angiogenesis Inhibitors / Choroid / Choroid Diseases / Cross-Sectional Studies / Female / Fluorescein Angiography / Humans / Intravitreal Injections / Male / Middle Aged / Receptors, Vascular Endothelial Growth Factor / Recombinant Fusion Proteins / Retina / Retrospective Studies / Tomography, Optical Coherence / Visual Acuity
(出版サイトへのリンク): ● Publication site (DOI): 10.1136/bjophthalmol-2016-309694
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27974321; ● Search Scopus @ Elsevier (PMID): 27974321; ● Search Scopus @ Elsevier (DOI): 10.1136/bjophthalmol-2016-309694

(DOI: 10.1136/bjophthalmol-2016-309694, PubMed: 27974321) Takamasa Kinoshita, Yoshinori Mitamura, Terumi Mori, Kei Akaiwa, Kentaro Senba, Mariko Egawa, Junya Mori, Shozo Sonoda and Taiji Sakamoto :
Changes in choroidal structures in eyes with chronic central serous chorioretinopathy after half-dose photodynamic therapy,
PLoS ONE, Vol.11, No.9, e0163104, 2016.

(要約): To determine the structural changes in the choroid after half-dose photodynamic therapy (hPDT) in eyes with chronic central serous chorioretinopathy (CSC). This was a retrospective interventional study of 29 eyes of 29 patients who underwent hPDT for chronic CSC with serous retinal detachment (SRD) and were followed for ≥3 months. Enhanced depth imaging optical coherence tomographic (EDI-OCT) images of the subfoveal choroid were converted to binary images. The central choroidal thickness (CCT), the cross sectional subfoveal choroidal area, the hyporeflective and hyperreflective areas of the inner, outer, and whole choroid were determined at the baseline, and at 1, 3, and 12 months after the hPDT. The SRDs were resolved in 26 (89.7%) eyes at 3 months after the hPDT. The mean CCT (P = 0.001), the total choroidal area (P = 0.001), and the hypo-reflective area (P = 0.003) of the whole choroid were significantly decreased from the baseline at 3 months. The hyperreflective area of whole choroid was not significantly changed during the study period (P = 0.083). The hyperreflective but not the hyporeflective area of the inner choroid was significantly decreased at 3 months (P = 0.001, P = 1.000, respectively). The hyporeflective but not the hyperreflective area of the outer choroid was significantly decreased at 3 months (P = 0.001, P = 1.000, respectively). The hyperreflective area of the inner choroid and hyporeflective area of the outer choroid were significantly decreased after hPDT for chronic CSC. Because the hyperreflective and hyporeflective area correspond to the choroidal stroma and vessels, respectively, the decreased CCT and subfoveal choroidal area after hPDT may be attributed to a decrease in the exudative changes in the inner choroidal stroma and the reduction of the dilation of the outer choroidal vessels.
(キーワード): Adult / Aged / Aged, 80 and over / Central Serous Chorioretinopathy / Choroid / Chronic Disease / Female / Fluorescein Angiography / Humans / Indocyanine Green / Male / Middle Aged / Photochemotherapy / Tomography, Optical Coherence
(徳島大学機関リポジトリ): ● Metadata: 112333
(出版サイトへのリンク): ● Publication site (DOI): 10.1371/journal.pone.0163104
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27636093; ● Search Scopus @ Elsevier (PMID): 27636093; ● Search Scopus @ Elsevier (DOI): 10.1371/journal.pone.0163104

(徳島大学機関リポジトリ: 112333, DOI: 10.1371/journal.pone.0163104, PubMed: 27636093) Mariko Egawa, Yoshinori Mitamura, Kei Akaiwa, Kentaro Senba, Takamasa Kinoshita, Eisuke Uchino, Shozo Sonoda and Taiji Sakamoto :
Changes of choroidal structure after corticosteroid treatment in eyes with Vogt-Koyanagi-Harada disease.,
The British journal of Ophthalmology, Vol.100, No.12, 1646-1650, 2016.

(要約): To report the changes of the choroidal structure in the enhanced depth imaging optical coherence tomographic (EDI-OCT) images after high-dose corticosteroid treatment for acute Vogt-Koyanagi-Harada (VKH) disease. Retrospective, observational case series. Thirty-four eyes of 17 patients with acute VKH disease were examined by EDI-OCT before, and 1, 4 and 52 weeks after the treatment. The EDI-OCT images were binarised by ImageJ, a publicly accessible software. The luminal, stromal and total choroidal areas and ratio of luminal/stromal area (L/S ratio) were measured in the subfoveal choroid of 1500 µm width. The area of the peripapillary atrophy (PPA) was measured in the fundus photographs at 1 and 52 weeks. For statistical analyses, a generalised estimating equation method was used to eliminate the effect of within-subject intereye correlations. Before treatment, the EDI-OCT images could not be binarised because of poor image quality in most of the cases. After treatment, the luminal, stromal and total choroidal areas were significantly decreased during the follow-up period (all p<0.05). The L/S ratio significantly fluctuated over time (p=0.0201), and was significantly lower at 4 weeks than at 1 week (p=0.0158). The L/S ratio at 1 week was significantly correlated with increase in the PPA area, subsequent chronic recurrences and total dose of corticosteroid (p<0.0001, p=0.0006, p=0.0037, respectively). The L/S ratio measured by binarisation of EDI-OCT images was predictive factor for the progression of PPA, subsequent chronic recurrences and total dose of corticosteroid, and may serve as a marker for degree of choroidal inflammation in the VKH disease.
(キーワード): Adult / Aged / Aged, 80 and over / Choroid / Dose-Response Relationship, Drug / Female / Fluorescein Angiography / Follow-Up Studies / Fundus Oculi / Glucocorticoids / Humans / Male / Middle Aged / Optic Disk / Retrospective Studies / Time Factors / Tomography, Optical Coherence / Treatment Outcome / Uveomeningoencephalitic Syndrome / Visual Acuity
(出版サイトへのリンク): ● Publication site (DOI): 10.1136/bjophthalmol-2015-307734
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26906951; ● Summary page in Scopus @ Elsevier: 2-s2.0-84960192046

(DOI: 10.1136/bjophthalmol-2015-307734, PubMed: 26906951, Elsevier: Scopus) Mariko Egawa, Yoshinori Mitamura, Hiroki Sano, Kei Akaiwa, Masanori Niki, Kentaro Senba, Shozo Sonoda and Taiji Sakamoto :
Changes of choroidal structure after treatment for primary intraocular lymphoma: retrospective, observational case series.,
BMC Ophthalmology, Vol.15, 136, 2015.

(要約): We report changes of choroidal structure determined by binarization of enhanced depth imaging optical coherence tomographic (EDI-OCT) images after treatment for primary intraocular lymphoma (PIOL). Five eyes of four patients with PIOL were examined by EDI-OCT before and 6 months after intravitreal methotrexate injections. In addition, 15 eyes of 15 normal individuals controlled by age and refractive error were examined by EDI-OCT. Binarization of the EDI-OCT images was performed using publicly accessible software (ImageJ). The examined area of the subfoveal choroid was 1,500 m wide, and the dark areas that represented the luminal areas were traced by the Niblack method. Wilcoxon signed rank test was used to determine the significance of changes in the subfoveal choroidal thickness, interstitial area, and luminal area. Mann-Whitney U test was used to compare the parameters in the eyes with pretreatment PIOL and normal control eyes. The subfoveal choroidal thickness was significantly decreased after treatment (P = 0.0431). In the binarized images, the interstitial area was significantly decreased after treatment (P = 0.0431), while the luminal area was not significantly changed (P = 0.8927). After delayed onset of PIOL, increased interstitial area, thickened choroid and unchanged luminal area were observed in one eye. The interstitial area and choroidal thickness were significantly increased in the eyes with pretreatment PIOL compared with the normal control eyes (P = 0.0207, P = 0.0495, respectively), while the luminal area was not significantly different (P = 0.2752). After treatment for PIOL, the EDI-OCT images showed a thinner choroid, and binarization of the EDI-OCT images showed significantly decreased interstitial areas compared with the luminal areas. The binarized EDI-OCT images can provide useful information on choroidal structure in eyes with PIOL, and combining these images with intraocular interleukin levels or fundus autofluorescence images should provide valuable information for determining the PIOL activity.
(キーワード): Aged / Antimetabolites, Antineoplastic / Choroid Diseases / Female / Humans / Intravitreal Injections / Lymphoma, Large B-Cell, Diffuse / Male / Methotrexate / Middle Aged / Retinal Neoplasms / Retrospective Studies / Tomography, Optical Coherence
(徳島大学機関リポジトリ): ● Metadata: 114770
(出版サイトへのリンク): ● Publication site (DOI): 10.1186/s12886-015-0127-7
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26482033; ● Search Scopus @ Elsevier (PMID): 26482033; ● Search Scopus @ Elsevier (DOI): 10.1186/s12886-015-0127-7

(徳島大学機関リポジトリ: 114770, DOI: 10.1186/s12886-015-0127-7, PubMed: 26482033) 江川麻理子, 井上昌幸, 林勇樹, 三田村佳典, 岸潤 :
長期にわたり多彩な眼症状が出現したIgG4関連疾患の1例,
臨床眼科, Vol.69, No.8, 1253-1258, 2015年.

(キーワード): 8
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390565159898589056

(CiNii: 1390565159898589056) Akiko Iwata, Yoshinori Mitamura, Masanori Niki, Kentaro Senba, Mariko Egawa, Takashi Katome, Shozo Sonoda and Taiji Sakamoto :
Binarization of enhanced depth imaging optical coherence tomographic images of an eye with Wyburn-Mason syndrome: a case report.,
BMC Ophthalmology, Vol.15, 19, 2015.

(要約): To report a thicker choroid and larger choroidal luminal area in an eye with Wyburn-Mason syndrome. To the best of our knowledge, this is the first report demonstrating an increase in the choroidal thickness and the luminal area in a case of Wyburn-Mason syndrome. In addition, we report the changing appearance of retinal arteriovenous malformations over a 16-year period. A 27-year-old woman, who was diagnosed with Wyburn-Mason syndrome at age 11 years, visited our clinic. Her best-corrected visual acuity was 20/12.5 in the right eye and light perception in the left eye. Severely dilated, tortuous vascular loops were distributed from the optic disc over all four quadrants of the left fundus. The vascular loops in some areas were more dilated and tortuous than 16 years earlier. Optical coherence tomography (OCT) showed retinal edema with cystic changes and enlarged choroidal vessel lumens in the left eye. The subfoveal choroidal thickness was manually measured by the caliper function in the enhanced depth imaging OCT (EDI-OCT) images. Binarization of the EDI-OCT images was performed with publicly accessible ImageJ software. The examined area of the subfoveal choroid was 1,500 m wide, and the dark areas representing the luminal areas were traced by the Niblack method. After determining the distance of each pixel, the luminal area was automatically calculated. The subfoveal choroidal thickness was 250 m in the right eye and 462 m in the left eye. The luminal area of the 1,500-m-wide subfoveal choroid was computed to be 307,165.6 m(2) in the right eye and 545,780.7 m(2) in the left eye. The EDI-OCT images showed a thicker choroid, and binarization of the EDI-OCT images showed that the luminal areas were significantly larger in the affected eye, suggesting a dilatation of the choroidal vessels. The results demonstrated that conversion of EDI-OCT images to binary images was a useful method to quantify the choroidal structure.
(キーワード): Adult / Arteriovenous Fistula / Arteriovenous Malformations / Choroid / Choroid Diseases / Female / Fluorescein Angiography / Humans / Neurocutaneous Syndromes / Organ Size / Retinal Artery / Retinal Vein / Tomography, Optical Coherence / Visual Acuity
(徳島大学機関リポジトリ): ● Metadata: 114771
(出版サイトへのリンク): ● Publication site (DOI): 10.1186/s12886-015-0014-2
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25884956; ● Search Scopus @ Elsevier (PMID): 25884956; ● Search Scopus @ Elsevier (DOI): 10.1186/s12886-015-0014-2

(徳島大学機関リポジトリ: 114771, DOI: 10.1186/s12886-015-0014-2, PubMed: 25884956) Akiko Mino, Yoshinori Mitamura, Takashi Katome, Kentaro Senba, Mariko Egawa and Takeshi Naito :
Case of adult-onset Coats' disease with epiretinal membrane treated with 25-gauge pars plana vitrectomy.,
The Journal of Medical Investigation : JMI, Vol.62, No.1-2, 85-88, 2015.

(要約): We describe a case of untreated adult-onset Coats' disease with a proliferative epiretinal membrane (ERM) treated successfully with 25-gauge pars plana vitrectomy (25GPPV). A 26-year-old man presented with a 3-week history of decreased vision in his left eye. At the initial examination, the decimal best-corrected visual acuity (BCVA) was 0.7 in the left eye. Ophthalmoscopy revealed the typical appearance of Stage 2A Coats' disease but with a proliferative ERM in the posterior pole. The patient received 2 monthly intravitreal injections of 2.5 mg bevacizumab, 5 laser photocoagulations to the area of telangiectasia, and 1 session of cryoretinopexy. Nine months after the initial visit, a traction by the ERM on the parafoveal area developed causing macular edema which reduced the BCVA to 0.3. He underwent 25GPPV with the removal of the ERM. In addition, the peripheral telangiectasia was treated intraoperatively with both laser photocoagulation and cryoretinopexy. Postoperatively, the traction to the parafoveal area was released and the BCVA improved to 0.6 which remained stable during the follow-up period of 13 months. We conclude that 25GPPV combined with ERM peeling, laser photocoagulation, and cryoretinopexy can be effective for adult-onset Coats' disease associated with an ERM.
(徳島大学機関リポジトリ): ● Metadata: 111256
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.62.85
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25817290; ● Summary page in Scopus @ Elsevier: 2-s2.0-84925861554

(徳島大学機関リポジトリ: 111256, DOI: 10.2152/jmi.62.85, PubMed: 25817290, Elsevier: Scopus) 江川麻理子, 仙波賢太郎, 宮本龍郎, 内藤毅, 三田村佳典 :
Listeria monocytogenesによる内因性眼内炎の1例,
臨床眼科, Vol.68, No.13, 1737-1740, 2014年.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390846634874992384; ● Summary page in Scopus @ Elsevier: 2-s2.0-84921444687

(CiNii: 1390846634874992384, Elsevier: Scopus) Takashi Katome, Kazuhiko Namekata, Yoshinori Mitamura, Kentaro Senba, Mariko Egawa, Takeshi Naito, Chikako Harada and Takayuki Harada :
Expression of intraocular peroxisome proliferator-activated receptor gamma in patients with proliferative diabetic retinopathy.,
Journal of Diabetes and its Complications, Vol.29, No.2, 275-281, 2014.

(要約): PPAR may play an important role in the pathogenesis of PDR.
(キーワード): Adult / Aged / Antibodies, Monoclonal, Humanized / Aqueous Humor / Bevacizumab / Cells, Cultured / Diabetes Mellitus, Type 1 / Diabetes Mellitus, Type 2 / 糖尿病網膜症 (diabetic retinopathy) / Epiretinal Membrane / Female / Human Umbilical Vein Endothelial Cells / Humans / Intravitreal Injections / Male / Middle Aged / PPAR gamma / Severity of Illness Index / Up-Regulation / Vascular Endothelial Growth Factor A / Vitreous Body
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jdiacomp.2014.10.010
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25468312; ● Summary page in Scopus @ Elsevier: 2-s2.0-84922991203

(DOI: 10.1016/j.jdiacomp.2014.10.010, PubMed: 25468312, Elsevier: Scopus) Yosuke Nakamura, Yoshinori Mitamura, Akira Hagiwara, Ken Kumagai, Gen Miura, Takeshi Sugawara, Mariko Egawa and Shuichi Yamamoto :
Relationship between retinal microstructures and visual acuity after cataract surgery in patients with retinitis pigmentosa.,
The British journal of Ophthalmology, Vol.99, No.4, 508-511, 2014.

(要約): To study the relationship between the retinal microstructures and the best-corrected visual acuity (BCVA) after cataract surgery in patients with retinitis pigmentosa (RP). 58 eyes of 43 consecutive RP patients who underwent cataract surgery were studied. The BCVA was measured before and 3 months after the surgery. The appearance of the inner segment/outer segment (IS/OS) line of the photoreceptors in the optical coherence tomographic (OCT) images at the fovea was graded; Grade 1, IS/OS line not visible; Grade 2, IS/OS line abnormal or discontinuous; and Grade 3, IS/OS line normal. The central foveal thickness (CFT) and the length of the IS/OS line were measured in the spectral-domain OCT images. The postoperative BCVAs in logMAR units (Grade 1, 1.04±0.36; Grade 2, 0.33±0.16; Grade 3, 0.08±0.14) and the improvements in the BCVA in logMAR units (Grade 1, 0.22±0.28; Grade 2, 0.53±0.48; Grade 3, 0.54±0.35) were significantly different among Grade 1, 2 and 3 groups (p<0.0001, p=0.0378; respectively). A postoperative BCVA of <0.2 logMAR units was achieved in 0% in Grade 1, 20% in Grade 2 and 74% in Grade 3 (p<0.0001). There was a significant correlation between the postoperative BCVA and the length of the IS/OS line (r=-0.601 p<0.0001) or the CFT (r=-0.510, p<0.0001). The presence of normal IS/OS line in the OCT images is associated with good visual recovery after cataract surgery in RP patients. The integrity of the IS/OS line may be important for predicting good postoperative BCVA.
(キーワード): Electroretinography / Female / Fluorescein Angiography / Humans / Lens Implantation, Intraocular / Male / Middle Aged / Phacoemulsification / Postoperative Period / Retinal Photoreceptor Cell Inner Segment / Retinal Photoreceptor Cell Outer Segment / Retinitis Pigmentosa / Retrospective Studies / Visual Acuity
(出版サイトへのリンク): ● Publication site (DOI): 10.1136/bjophthalmol-2013-304819
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25336579; ● Search Scopus @ Elsevier (PMID): 25336579; ● Search Scopus @ Elsevier (DOI): 10.1136/bjophthalmol-2013-304819

(DOI: 10.1136/bjophthalmol-2013-304819, PubMed: 25336579) Mariko Egawa, Yoshinori Mitamura, Yuki Hayashi, Kentaro Semba and Takeshi Naito :
Changes of fundus autofluorescence and spectral-domain optical coherence tomographic findings after treatment of primary intraocular lymphoma.,
Journal of Ophthalmic Inflammation and Infection, Vol.4, No.1, 7, 2014.

(要約): We report the fundus autofluorescence (FAF), spectral-domain optical coherence tomographic (SD-OCT), microperimetric, and multifocal electroretinographic (mfERG) findings before, during, and after successful treatment of a primary intraocular lymphoma (PIOL). A 57-year-old man had biopsy-proven PIOL in his left eye, and he was treated with intravitreal methotrexate injections for 8 months. Before treatment, fundus examination disclosed many small, yellow lesions with distinct boundaries in the posterior fundus which became atrophic 9 months after the initial treatment. FAF showed a pattern of granular hypoautofluorescence and hyperautofluorescence before the treatments and patchy hypoautofluorescence corresponding to retinal pigment epithelial (RPE) atrophy after the treatments. SD-OCT showed increased nodularity at the level of and above the RPE, a separation of Bruch membrane from the RPE, partial damage of the RPE, disruption of the photoreceptor inner segment/outer segment (IS/OS) junction, multiple hyperreflective signals in the inner retina, foveal thinning, and parafoveal thickening. After treatment, the hyperreflective infiltrations in the inner retina were markedly decreased, and the RPE and IS/OS junction were restored. The foveal thinning and parafoveal thickening resolved, and the central choroidal thickness decreased. During the follow-up, the mfERGs remained decreased. In contrast, microperimetry showed a partial improvement of the retinal sensitivity. FAF and SD-OCT are useful noninvasive methods to evaluate the retinal and choroidal changes before and after treatment of PIOL. Our results suggest that visual recovery after successful treatment may be limited once macula is infiltrated.
(出版サイトへのリンク): ● Publication site (DOI): 10.1186/1869-5760-4-7
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24559259; ● Search Scopus @ Elsevier (PMID): 24559259; ● Search Scopus @ Elsevier (DOI): 10.1186/1869-5760-4-7

(DOI: 10.1186/1869-5760-4-7, PubMed: 24559259) Mariko Egawa, Yoshinori Mitamura, Yuki Hayashi and Takeshi Naito :
Spectral-domain optical coherence tomographic and fundus autofluorescence findings in eyes with primary intraocular lymphoma.,
Clinical Ophthalmology, Vol.8, 335-341, 2014.

(要約): The purpose of this study was to evaluate the findings on spectral-domain optical coherence tomography (SD-OCT) and fundus autofluorescence (FAF) in three eyes with primary intraocular lymphoma (PIOL). The medical records of three eyes from three patients with biopsy-proven PIOL and retinal infiltrations were reviewed. The SD-OCT and fluorescein angiographic findings were evaluated in the three eyes and FAF images in two eyes. The PIOL in the three patients was monocular. Vitreous opacities and retinal infiltrations were observed in the three eyes, and iritis was present in two eyes. The cytologic diagnosis was class V in two eyes and class III in one eye. The interleukin-10/interleukin-6 ratio was >1.0 in the vitreous and aqueous humor of the three eyes. The FAF images for two eyes showed abnormal granular hyperautofluorescence and hypoautofluorescence which were the reverse of the pattern in the fluorescein angiographic images. In all three eyes, SD-OCT showed hyper-reflective infiltrations at the level of the retinal pigment epithelium (RPE), a separation of the Bruch membrane from the RPE, damage to the RPE, disruption of the photoreceptor inner segment/outer segment junction, and multiple hyper-reflective signals in the inner retina. Because of the characteristic FAF and SD-OCT findings in these eyes with PIOL, we suggest that these noninvasive methods may be used for a rapid diagnosis of PIOL and also for understanding the pathology of PIOL.
(出版サイトへのリンク): ● Publication site (DOI): 10.2147/OPTH.S58114
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24520190; ● Summary page in Scopus @ Elsevier: 2-s2.0-84893558804

(DOI: 10.2147/OPTH.S58114, PubMed: 24520190, Elsevier: Scopus) 江川麻理子, 林勇樹, 三田村佳典 :
Vogt-小柳-原田病の病型と予後の検討,
臨床眼科, Vol.67, No.6, 981-984, 2013年.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390283684921194112; ● Summary page in Scopus @ Elsevier: 2-s2.0-84879208583

(CiNii: 1390283684921194112, Elsevier: Scopus) 山中千尋, 江川麻理子, 三田村佳典 :
若年発症サルコイドーシス/Blau症候群の1例,
臨床眼科, Vol.67, No.4, 563-568, 2013年.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390283684920468992; ● Summary page in Scopus @ Elsevier: 2-s2.0-84876397624

(CiNii: 1390283684920468992, Elsevier: Scopus) 林勇樹, 江川麻理子, 三田村佳典 :
脈絡膜趨壁が観察された急性後部多発性斑状色素上皮症の1例,
臨床眼科, Vol.66, No.8, 1225-1228, 2012年.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390002209944286208; ● Summary page in Scopus @ Elsevier: 2-s2.0-84865701471

(CiNii: 1390002209944286208, Elsevier: Scopus) 江川麻理子, 林勇樹, 三田村佳典, 冨田真知子 :
網膜静脈周囲炎が顕著であったmultiple evanescent white dot syndromeの小児例,
眼科, Vol.54, No.6, 797-800, 2012年.

(キーワード): 多発消失性白点症候群 / 網膜静脈周囲炎 / 小児 / multiple evanescent white dot syndrome / MEWDS / retinal periphlebitis / child
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1523106605090306560

(CiNii: 1523106605090306560) 林勇樹, 江川麻理子, 内藤毅, 三田村佳典 :
眼内悪性リンパ腫の鑑別のため硝子体生検を施行した21例の検討,
臨床眼科, Vol.65, No.7, 1069-1073, 2011年.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390283684920898176; ● Summary page in Scopus @ Elsevier: 2-s2.0-80051692735

(CiNii: 1390283684920898176, Elsevier: Scopus) 山中千尋, 江川麻理子, 三田村佳典, 松井尚子, 梶龍兒 :
抗アクアポリン4抗体陽性視神経炎の臨床像 (特集第64回日本臨床眼科学会講演集(2)),
臨床眼科, Vol.65, No.4, 521-526, 2011年.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1521417755902852864; ● Summary page in Scopus @ Elsevier: 2-s2.0-79955804438

(CiNii: 1521417755902852864, Elsevier: Scopus)

MISC

田原裕子, 四宮加容, 江川麻理子 :
内視鏡下鼻内手術に伴う眼窩内損傷,
眼科臨床紀要, Vol.16, No.7, 540-541, 2023年. 三﨑貴文, 江川麻理子, 三田村佳典 :
抗M O G抗体陽性視神経炎の臨床像の検討,
眼科臨床紀要, Vol.16, No.7, 540, 2023年.

総説・解説

江川麻理子 :
ぶどう膜炎と脈絡膜,
臨床眼科, Vol.70, No.13, 1840-1847, 2016年12月.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390565159897368576; ● Summary page in Scopus @ Elsevier: 2-s2.0-85010199530

(CiNii: 1390565159897368576, Elsevier: Scopus)

講演・発表

田原裕子, 江川麻理子, 佐埜弘樹, 三田村佳典 :
多彩な眼症状を呈した再発性多発軟骨炎の一例,
第77回日本臨床眼科学会総会, 2023年10月. 三﨑貴文, 江川麻理子, 三田村佳典 :
徳島大学病院における抗MOG抗体陽性視神経炎の臨床像の検討,
第77回日本臨床眼科学会総会, 2023年10月. 山田将之, 江川麻理子, 三﨑貴文, 三田村佳典 :
ASPPCや虹彩内芽腫など多彩な所見を呈した梅毒性ぶどう膜炎の3例,
第77回日本臨床眼科学会総会, 2023年10月. 近藤広宗, 江川麻理子, 村尾史子, 三田村佳典 :
同時期に急性網膜壊死とサイトメガロウイルス網膜炎を併発した1例,
第126回日本眼科学会総会, 2022年4月. 江川麻理子, 三田村佳典, 三浦玄, 馬場隆之, 山本修一 :
網膜色素変性における脈絡膜構造と視機能の経過的変化の関係,
第126回日本眼科学会総会, 2022年4月. 江川麻理子, 三田村佳典 :
網膜色素変性の脈絡膜構造の経時的変化,
第75回日本臨床眼科学会, 2021年10月. 南佳佑, 江川麻理子, 梶田敬介, 三田村佳典 :
イピリムマブ併用ニボルマブ投与後にVogt-小柳-原田病様の汎ぶどう膜炎を呈した1例,
第74回日本臨床眼科学会, 2020年10月. 佐埜弘樹, 江川麻理子, 三田村佳典 :
悪性リンパ腫の虹彩毛様体転移にMTXの硝子体内注射と放射線治療を行った1例,
第74回日本臨床眼科学会, 2020年10月. 仁木昌徳, 江川麻理子, 梶田敬介, 三田村佳典 :
網膜深層の血管減少を認めたacute macular neuroretinopathyの2例,
第74回日本臨床眼科学会, 2020年10月. 森木冠奈, 江川麻理子, 三田村佳典 :
強皮症による偽性腸閉塞からビタミンA欠乏性夜盲となった1例,
第74回日本臨床眼科学会, 2020年10月. 江川麻理子, 佐埜弘樹, 樋端透史, 三田村佳典 :
サイトメガロウイルスによる慢性網膜壊死の2例,
第74回日本臨床眼科学会, 2020年10月. 森木冠奈, 江川麻理子, 赤岩慶, 三田村佳典 :
著明な杆体障害が見られた多発消失性白点症候群の1例,
2019年10月. 香留崇, 赤岩慶, 江川麻理子, 仙波賢太郎, 三田村佳典 :
硝子体手術後に黄斑円孔網膜剥離を合併したサイトメガロウイルス網膜炎の一例,
第73回日本臨床眼科学会, 2019年10月. 梶田敬介, 江川麻理子, 三田村佳典 :
ぶどう膜炎の黄斑浮腫に対しメトトレキサート硝子体注射を行った2症例,
第72回日本臨床眼科学会, 2018年10月. 藤本智子, 宮本龍郎, 江川麻理子, 三田村佳典 :
遠視化をきたしたビスホスネート製剤によるぶどう膜・眼窩内炎症の1例,
第71回日本臨床眼科学会(2017/10/12-15), 2017年10月. 江川麻理子, 三田村佳典, 三浦玄, 山本修一, 園田祥三, 坂本泰二 :
網膜色素変性における脈絡膜構造の層別解析と視機能の検討,
第71回日本臨床眼科学会2017/10/12-15), 2017年10月. 江川麻理子, 三田村佳典, 園田祥三, 坂本泰二 :
網膜色素変性の黄斑浮腫治療に伴う脈絡膜変化が見られた1例,
第70回日本臨床眼科学会, 2016年11月. 森輝実, 宮本龍郎, 江川麻理子, 三田村佳典, 市原裕子, 岡村和美, 渡邊浩良 :
原田病に類似した両眼性漿液性網膜剥離を呈した急性リンパ性白血病の1例,
第70回日本臨床眼科学会, 2016年11月. 岩田明子, 四宮加容, 大串陽子, 江川麻理子, 三田村佳典 :
徳島大学病院における未熟児網膜症の検討,
第41回日本小児眼科学会総会, 2016年6月. 江川麻理子, 三田村佳典, 中村洋介, 山本修一, 園田祥三, 坂本泰二 :
網膜色素変性における視機能と脈絡膜構造の関係,
第120回日本眼科学会総会, 2016年4月. 江川麻理子, 三田村佳典, 園田祥三, 坂本泰二 :
Vogt-小柳-原田病の治療後における脈絡膜構造の変化,
第69回日本臨床眼科学会/2015.10.23/名古屋, 2015年10月. 廣瀬憲志, 久保宜明, 江川麻理子, 鈴木正和 :
TNF-α抗体加療中に両眼性ぶどう膜炎を発症した尋常性乾癬の1例,
第30回日本乾癬学会, 2015年9月. 江川麻理子, 林勇樹, 三田村佳典, 園田祥三, 坂本泰二 :
眼内悪性リンパ腫におけるOCT画像2値化による治療前後の脈絡膜構造像の変化,
第119回日本眼科学会総会 2015.4.16∼19 札幌, 2015年4月. 江川麻理子, 井上昌幸, 林勇樹, 三田村佳典 :
長期にわたり多彩な眼症状が出現したIgG4関連疾患の1例,
第68回日本臨床眼科学会, 2014年11月. 林勇樹, 江川麻理子, 宮本龍郎, 三田村佳典 :
Good症候群に合併したサイトメガロウイルス網膜炎の1例,
第48回日本眼炎症学会, 2014年7月. 江川麻理子, 堀田芙美香, 林勇樹, 三田村佳典 :
サルコイドーシス関連視神経症の1例,
第48回日本眼炎症学会, 2014年7月. 四宮加容, 江川麻理子, 北村嘉章, 岡本里江, 木虎亜希子, 三田村佳典 :
涙嚢鼻腔吻合術後のコントラスト視力と両眼視機能.第118回日本眼科学会総会(2014.4.2-6，東京),
第118回日本眼科学会総会(2014.4.2-6,東京), 2014年4月. 江川麻理子, 林勇樹, 内藤毅, 三田村佳典 :
眼内悪性リンパ腫の網膜機能を検討した1例,
第67回日本臨床眼科学会, 2013年11月. 江川麻理子, 林勇樹, 内藤毅, 三田村佳典 :
原発性眼内悪性リンパ腫の臨床像の検討,
第117回日本眼科学会総会, 2013年4月. 林勇樹, 長澤利彦, 江川麻理子, 三田村佳典 :
Swept source OCTを用いた脈絡膜骨腫の観察,
第117回日本眼科学会総会, 2013年3月. 江川麻理子, 林勇樹, 三田村佳典 :
Vogt-小柳-原田病の病型と予後の検討,
第66回日本臨床眼科学会, 2012年10月. 林勇樹, 江川麻理子, 内藤毅, 三田村佳典 :
黄斑浮腫を伴う脈絡膜骨腫にベバシズマブ硝子体注射を施行した2例,
第66回日本臨床眼科学会, 2012年10月. 山中千尋, 江川麻理子, 林勇樹, 三田村佳典 :
家族内発症を有する小児サルコイドーシスの1例,
第66回日本臨床眼科学会, 2012年10月. Y Yokota, M Kadota, 伊勢孝之, 岩瀬俊, T Hara, R Ota, Y Kawabata, K Ogasawara, 坂東美佳, S Bando, T Matsuura, 仁木敏之, J Hotchi, N Tomita, 上田由佳, 山口浩司, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 佐田政隆, 赤池雅史, 江川麻理子, 三田村佳典 :
眼病変の経過中に心室中隔の肥厚および完全房室ブロックで発症した心サルコイドーシスの一例,
第245回徳島医学会学術集会(平成24年度夏期), 2012年7月. 江川麻理子, 秦裕子, 井上昌幸, 林勇樹, 三田村佳典 :
サイトメガロウイルス虹彩炎の臨床像の検討,
第46回日本眼炎症学会, 2012年7月. 江川麻理子, 江口洋, 仙波賢太郎, 内藤毅, 三田村佳典 :
Listeriaによる内因性眼内炎の1例,
第65回日本臨床眼科学会, 2011年10月. 林勇樹, 江川麻理子, 長澤利彦, 三田村佳典 :
脈絡膜趨壁を認めた急性後部多発性斑状色素上皮症の1例,
第65回日本臨床眼科学会, 2011年10月. 江川麻理子, 山中千尋, 三田村佳典 :
OCTで病巣を観察できた眼トキソカラ症の1例,
第45回日本眼炎症学会, 2011年7月. 林勇樹, 江川麻理子, 井上昌幸, 三田村佳典 :
網膜色素上皮剥離を伴った原田病の2例,
第45回日本眼炎症学会, 2011年7月. 山中千壽, 江川麻理子 :
抗アクアポリン4抗体陽性視神経炎の8例,
第64回日本臨床眼科学会, 2010年11月. 林勇樹, 江川麻理子 :
眼内悪性リンパ腫の鑑別のために硝子体生検を施行した17例の検討,
第64回日本臨床眼科学会, 2010年11月.

研究会・報告書: 田原裕子, 四宮加容, 江川麻理子, 三田村佳典 :
内視鏡下鼻内手術に伴う眼窩内損傷,
第82回徳島眼科集談会, 2022年12月. 三﨑貴文, 江川麻理子, 三田村佳典 :
抗M O G抗体陽性視神経炎の臨床像の検討,
第82回徳島眼科集談会, 2022年12月. 江川麻理子 :
徳島大学病院における網膜色素変性症専門外来の歩みと今後の展望,
日本網膜色素変性症協会(JRPS) 徳島支部医療講演会, 2022年3月. 梶田敬介, 江川麻理子, 三田村佳典 :
Acute macular neuroretinopathyと診断された1例,
第81回徳島眼科集談会, 2019年12月. 森木冠奈, 江川麻理子, 三田村佳典 :
強皮症による偽性腸閉塞からビタミンA欠乏性夜盲となった1例,
第81回徳島眼科集談会, 2019年12月. 南佳佑, 江川麻理子, 三田村佳典 :
自然軽快・再燃を繰り返した結核性ぶどう膜炎の一例,
第8回徳島眼科集談会, 2019年12月. 佐埜弘樹, 赤岩慶, 江川麻理子, 三田村佳典 :
Neuromyelitis optica spectrum disorders (NMOSD)の2例,
第80回徳島眼科集談会, 2018年12月. 江川麻理子, 秦裕子, 井上昌幸, 美馬彩, 三田村佳典 :
当院におけるサイトメガロウイルス虹彩炎の臨床像,
第80回徳島眼科集談会, 2018年12月. 谷彰浩, 江川麻理子, 藤本智子, 仙波賢太郎, 三田村佳典 :
眼内悪性リンパ腫の5例,
第79回徳島眼科集談会(2017/12/10), 2017年12月. 江川麻理子, 猪本尚毅, 三田村佳典, 松本惣一 :
黄斑部毛細血管拡張症Type2と考えられた2症例,
第77回徳島眼科集談会/2015.12.13/徳島, 2015年12月. 森輝実, 大豆本恵里名奈, 宮本龍郎, 江川麻理子, 三田村佳典, 市原裕子, 岡村和美, 渡邊浩良 :
再々発時に両眼性の漿液性網膜剥離を合併した急性リンパ性白血病の1例,
第77回徳島眼科集談会/2015.12.13/徳島, 2015年12月. 栗田斉, 木虎亜希子, 岡本里江, 伊藤浩太郎, 宮下領介, 直江幸美, 井坂ゆう, 江川麻理子, 三田村佳典 :
徳島大学病院における網膜色素変性外来の紹介,
第77回徳島眼科集談会/2015.12.13 徳島, 2015年12月. 林勇樹, 江川麻理子, 堀田芙美香, 宮本龍郎, 三田村佳典 :
サイトメガロウイルス網膜炎の5症例,
第75回徳島眼科集談会, 2013年12月. 江川麻理子, 林勇樹, 内藤毅, 三田村佳典 :
眼内悪性リンパ腫11例の臨床像,
第74回徳島眼科集談会, 2012年12月. 江川麻理子 :
眼サルコイドーシスから心サルコイドーシスを来たした1例,
徳島CORRND研究会, 2012年6月. 江川麻理子, 樋端透史, 内藤毅, 三田村佳典 :
結核性ぶどう膜炎の1例,
第73回徳島眼科集談会, 2011年12月. 江川麻理子 :
血管新生緑内障で発見された眼サルコイドーシスの2例,
徳島CORRND研究会, 2011年12月. 冨田真知子, 江川麻理子 :
網膜静脈周囲炎が顕著であったMEWDSの小児例,
第72回徳島眼科集談会, 2010年12月. 林勇樹, 江川麻理子 :
メトトレキサート硝子体注射が有効であった眼内悪性リンパ腫の1例,
第72回徳島眼科集談会, 2010年12月. 山中千壽, 江川麻理子 :
抗アクアポリン抗体陽性視神経炎の9例,
第72回徳島眼科集談会, 2010年12月. 江川麻理子 :
発症初期から経過が追えた眼トキソカラ症の1例,
第72回徳島眼科集談会, 2010年12月.

特許: 研究者総覧に該当データはありませんでした。
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補助金・競争的資金: 糖尿病網膜症の病因におけるCdk5/ERK回路の役割 (研究課題/領域番号: 22K09814 )
サイクリン依存性キナーゼ５を標的とした糖尿病網膜症治療 (研究課題/領域番号: 19K09951 )
糖尿病網膜症の病因におけるPPARγを介したサイクリン依存性キナーゼ5の役割 (研究課題/領域番号: 16K11288 )
PPARγを標的とした糖尿病網膜症治療 (研究課題/領域番号: 25462717 )
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研究者総覧で最新データを確認する

2024年12月20日更新

専門分野・研究分野: 医学 (Medicine)
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受賞: 2013年11月, 第117回日本眼科学会総会学術展示優秀賞受賞 (日本眼科学会)
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2024年12月21日更新

研究者番号: 70507657

所属（現在）: 2024/4/1 : 徳島大学, 病院, 講師

所属（過去の研究課題 情報に基づく）*注記: 2018/4/1 – 2022/4/1 : 徳島大学, 大学院医歯薬学研究部(医学域), 講師
2016/4/1 – 2017/4/1 : 徳島大学, 大学院医歯薬学研究部(医学系), 講師
2015/4/1 : 徳島大学, 大学院医歯薬学研究部, 講師
2013/4/1 – 2014/4/1 : 徳島大学, ヘルスバイオサイエンス研究部, 助教

審査区分/研究分野: 研究代表者以外

生物系 / 医歯薬学 / 外科系臨床医学 / 眼科学
小区分56060:眼科学関連

キーワード: 研究代表者以外

外科 / 細胞・組織 / 生体分子 / 糖尿病 / 臨床

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江川 麻理子

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江川麻理子