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堤理恵

徳島大学

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2023年3月22日更新

職名: 講師
電話: 088-633-9214
電子メール: rtsutsumi@tokushima-u.ac.jp
学歴: 2006/3: 徳島大学大学院栄養学研究科博士課程修了
学位: 博士(栄養学) (徳島大学) (2006年3月)
職歴・経歴: 2010/4: 徳島大学助教, 大学院ヘルスバイオサイエンス研究部 (-2015.3.)
2015/4: 徳島大学助教, 大学院医歯薬学研究部 (-2018.4.)
2018/5: 徳島大学講師, 大学院医歯薬学研究部

専門分野・研究分野: 保健学 (Health Studies)
臨床栄養学 (Clinical Nutrition)

研究者総覧で最新データを確認する

2023年3月22日更新

専門分野・研究分野: 保健学 (Health Studies)
臨床栄養学 (Clinical Nutrition)
担当経験のある授業科目: ライフステージ栄養学総合演習 (学部)
医療栄養学概論 (大学院)
医療栄養学特論 (大学院)
応用栄養学実習 (学部)
応用栄養学演習 (学部)
栄養と薬 (学部)
栄養情報処理学実習 (学部)
栄養教育論2 (学部)
栄養教育論実習 (学部)
栄養英語 (学部)
疾患栄養管理学Ⅱ (学部)
臨床医学入門 (学部)
臨床栄養学概論 (大学院)
指導経験: 1人 (修士)

研究者総覧で最新データを確認する

2023年3月22日更新

専門分野・研究分野: 保健学 (Health Studies)
臨床栄養学 (Clinical Nutrition)

研究テーマ: 研究者総覧に該当データはありませんでした。

著書

三島優奈, 堤理恵, 阪上浩 :
侵襲時のオートファジー制御とn‐3系脂肪酸投与,
日本外科代謝栄養学会, 2019年8月.

(キーワード): オートファジー / 侵襲
(出版サイトへのリンク): ● Publication site (DOI): 10.11638/jssmn.53.6_281
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390846609793694208; ● Search Scopus @ Elsevier (DOI): 10.11638/jssmn.53.6_281

(DOI: 10.11638/jssmn.53.6_281, CiNii: 1390846609793694208) 堤理恵 :
Whey peptide and microbiota,
California, 2019年7月. 堤理恵 :
柚香本,
徳島, 2019年4月. 武田英二, 鈴木佳子, 松村晃子, 中屋豊, 堤理恵, 阪上浩, 濵田康弘, 秦明子, 他42人 :
認定NSTガイドブック2017 改訂第5版,
2017年7月. 堤理恵, 阪上浩, 堤保夫 :

2015年8月. 堤理恵 :
NEXT臨床栄養学改訂2版,
講談社サイエンティフィック, 東京, 2015年3月. 堤理恵, 西村匡司 :
救急，重症患者での栄養評価,
株式会社羊土社, 2014年11月. 堤理恵, 西村匡司 :
救急，重症患者での栄養評価,
株式会社羊土社, 2014年. 堤理恵 :
NSTガイドブック,
メディカルレビュー社, 東京, 2014年.

(キーワード): 栄養 (nutrition)

堤理恵 :
PICUにおける栄養管理─エネルギー，たんぱく質，脂肪乳剤，特殊栄養素,
医歯薬出版株式会社, 東京, 2013年. 堤理恵 :
臨床栄養学,
講談社サイエンティフィック, 東京, 2012年4月.

論文

Kana Beppu, Rie Tsutsumi, Satoshi Ansai, Nana Ochiai, Mai Terakawa, Marie Mori, Masashi Kuroda, Kazuki Horikawa, Takumi Tomoi, Joe Sakamoto, Yasuhiro Kamei, Kiyoshi Naruse and Hiroshi Sakaue :
Development of a screening system for agents that modulate taste receptor expression with the CRISPR-Cas9 system in medaka.,
Biochemical and Biophysical Research Communications, Vol.601, 65-72, 2022.

(要約): Taste recognition mediated by taste receptors is critical for the survival of animals in nature and is an important determinant of nutritional status and quality of life in humans. However, many factors including aging, diabetes, zinc deficiency, infection with influenza or cold viruses, and chemotherapy can trigger dysgeusia, for which a standard treatment has not been established. We here established an engineered strain of medaka (Oryzias latipes) that expresses green fluorescent protein (GFP) from the endogenous taste 1 receptor 3 (T1R3) gene locus with the use of the CRISPR-Cas9 system. This T1R3-GFP knock-in (KI) strain allows direct visualization of expression from this locus by monitoring of GFP fluorescence. The pattern of GFP expression in the T1R3-GFP KI fish thus mimicked that of endogenous T1R3 gene expression. Furthermore, exposure of T1R3-GFP KI medaka to water containing monosodium glutamate or the anticancer agent 5-fluorouracil resulted in an increase or decrease, respectively, in GFP fluorescence intensity, effects that also recapitulated those on T1R3 mRNA abundance. Finally, screening for agents that affect GFP fluorescence intensity in T1R3-GFP KI medaka identified tryptophan as an amino acid that increases T1R3 gene expression. The establishment of this screening system for taste receptor expression in medaka provides a new tool for the development of potential therapeutic agents for dysgeusia.
(キーワード): Animals / CRISPR-Cas Systems / Dysgeusia / 遺伝子発現 (gene expression) / Green Fluorescent Proteins / Oryzias / 生活の質 (quality of life) / Taste
(徳島大学機関リポジトリ): ● Metadata: 116998
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.bbrc.2022.02.082
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35228123; ● Search Scopus @ Elsevier (PMID): 35228123; ● Search Scopus @ Elsevier (DOI): 10.1016/j.bbrc.2022.02.082

(徳島大学機関リポジトリ: 116998, DOI: 10.1016/j.bbrc.2022.02.082, PubMed: 35228123) Hirofumi Tenshin, Jumpei Teramachi, Mohannad Ashtar, Masahiro Hiasa, Yusuke Inoue, Asuka Oda, Kotaro Tanimoto, Sou Shimizu, Yoshiki Higa, Takeshi Harada, Masahiro Oura, Kimiko Sogabe, Tomoyo Hara, Ryohei Sumitani, Tomoko Maruhashi, Mayu Sebe, Rie Tsutsumi, Hiroshi Sakaue, Itsuro Endo, Toshio Matsumoto, Eiji Tanaka and Masahiro Abe :
TGF-β-activated kinase-1 inhibitor LL-Z1640-2 reduces joint inflammation and bone destruction in mouse models of rheumatoid arthritis by inhibiting NLRP3 inflammasome, TACE, TNF-α and RANKL expression.,
Clinical & translational immunology, Vol.11, No.1, 2022.

(要約): TAK1 inhibition with LLZ may become a novel treatment strategy to effectively alleviate inflammasome-mediated inflammation and RANKL-induced osteoclastic bone destruction in joints alongside its potent suppression of TNF-α and IL-6 production and proteinase-mediated pathological processes in RA.
(徳島大学機関リポジトリ): ● Metadata: 117260
(出版サイトへのリンク): ● Publication site (DOI): 10.1002/cti2.1371
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35079379; ● Search Scopus @ Elsevier (PMID): 35079379; ● Search Scopus @ Elsevier (DOI): 10.1002/cti2.1371

(徳島大学機関リポジトリ: 117260, DOI: 10.1002/cti2.1371, PubMed: 35079379) Kana Beppu, Ayuka Kawakami, Yuna Mishima, Rie Tsutsumi, Masashi Kuroda, Hiroyasu Mori, Akio Kuroda, Munehide Matsuhisa and Hiroshi Sakaue :
Taste receptor gene expression is associated with decreased eGFR in patients with diabetes.,
The Journal of Medical Investigation : JMI, Vol.69, No.1.2, 120-126, 2022.

(要約): Dysgeusia is not only associated with zinc deficiency but also with certain drugs or diseases, including diabetes and renal failure. It often lowers the patient's quality of life and hinders access to proper nutrition. The underlying mechanism is unclear and there is a lack of awareness among patients. Here, we focused on lingual taste receptor gene expression in diabetes and elucidated the relationship between taste receptor gene expression and renal function. Forty-seven patients with diabetes and 10 healthy subjects (control group) were enrolled. Lingual foliate papillae were scraped and the derived cDNA was quantified by real-time polymerase chain reaction. Dysgeusia was assessed using SALSAVE?. All statistical analyses were performed using JMP? software 13. The expression of T1R1 and T1R2 was significantly upregulated in type 2 diabetes patients as compared with that in healthy subjects (P<0.01) but did not change in type 1 diabetes patients. T1R3 expression positively correlated and Scnn1 expression negatively correlated with estimated glomerular filtration rate, suggesting that altered taste receptor gene expression could reflect impaired renal function. Thus, alterations in T1R3 and Scnn1 expression in diabetes correlated with renal function. Taste receptor gene expression dysregulation could indicate dysgeusia associated with impaired renal function in patients with diabetes. J. Med. Invest. 69 : 120-126, February, 2022.
(キーワード): Diabetes Mellitus, Type 2 / Dysgeusia / Gene Expression / Humans / Quality of Life / Receptors, G-Protein-Coupled / Taste
(徳島大学機関リポジトリ): ● Metadata: 117023
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.69.120
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35466133; ● Search Scopus @ Elsevier (PMID): 35466133; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.69.120

(徳島大学機関リポジトリ: 117023, DOI: 10.2152/jmi.69.120, PubMed: 35466133) Atsushi Morio, Rie Tsutsumi, Shiho Satomi, Takashi Kondo, Hirotsugu Miyoshi, Takahiro Kato, Masashi Kuroda, Tadahiro Kitamura, Kenta Hara, Noboru Saeki, Hiroshi Sakaue and Yasuo M. Tsutsumi :
Leucine imparts cardioprotective effects by enhancing mTOR activity and mitochondrial fusion in a myocardial ischemia/reperfusion injury murine model.,
Diabetology & Metabolic Syndrome, Vol.13, No.1, 2021.

(要約): mice. Additionally, Leu increased the percentage of fused mitochondria and the mitochondrial volume, and decreased the number of mitochondria per cell in isolated cardiomyocytes. In HFD-induced obese mice, Leu treatment significantly reduced infarct size (41.0% ± 1.1% vs. 51.0% ± 1.4%, n = 7, p < 0.05), which was not induced by ischemic preconditioning, and this effect was inhibited by Rap. Furthermore, we observed enhanced mTOR protein expression and mitochondrial fusion with decreased reactive oxygen species production with Leu treatment in HFD-induced obese mice, but not in mTOR
(徳島大学機関リポジトリ): ● Metadata: 117442
(出版サイトへのリンク): ● Publication site (DOI): 10.1186/s13098-021-00755-z
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34801078; ● Search Scopus @ Elsevier (PMID): 34801078; ● Search Scopus @ Elsevier (DOI): 10.1186/s13098-021-00755-z

(徳島大学機関リポジトリ: 117442, DOI: 10.1186/s13098-021-00755-z, PubMed: 34801078) Rie Tsutsumi, Yuki Yamasaki, Jiro Takeo, Hiroko Miyahara, Mayu Sebe, Masahiro Bando, Yousuke Tanba, Yuna Mishima, Kana Takeji, Nanako Ueshima, Masashi Kuroda, Saeko Masumoto, Nagakatsu Harada, Daiju Fukuda, Ryoko Yoshimoto, Yasuo M. Tsutsumi, Ken-ichi Aihara, Masataka Sata and Hiroshi Sakaue :
Long-chain monounsaturated fatty acids improve endothelial function with altering microbial flora,
Translational Research : The Journal of Laboratory and Clinical Medicine, Vol.237, 16-30, 2021.

(要約): Fish oil-derived long-chain monounsaturated fatty acids (LCMUFAs) with a carbon chain length longer than 18 units ameliorate cardiovascular risk in mice. In this study, we investigated whether LCMUFAs could improve endothelial functions in mice and humans. In a double-blind, randomized, placebo-controlled, parallel-group, multi-center study, healthy subjects were randomly assigned to either an LCMUFA oil (saury oil) or a control oil (olive and tuna oils) group. Sixty subjects were enrolled and administrated each oil for 4 weeks. For the animal study, ApoE mice were fed a Western diet supplemented with 3% of either gadoleic acid (C20:1) or cetoleic acid (C22:1) for 12 weeks. Participants from the LCMUFA group showed improvements in endothelial function and a lower trimethylamine-N-oxide level, which is a predictor of coronary artery disease. C20:1 and C22:1 oils significantly improved atherosclerotic lesions and plasma levels of several inflammatory cytokines, including IL-6 and TNF-α. These beneficial effects were consistent with an improvement in the gut microbiota environment, as evident from the decreased ratio of Firmicutes and/ or Bacteroidetes, increase in the abundance of Akkermansia, and upregulation of short-chain fatty acid (SCFA)-induced glucagon-like peptide-1 (GLP-1) expression and serum GLP-1 level. These data suggest that LCMUFAs alter the microbiota environment that stimulate the production of SCFAs, resulting in the induction of GLP-1 secretion. Fish oil-derived long-chain monounsaturated fatty acids might thus help to protect against cardiovascular disease.
(徳島大学機関リポジトリ): ● Metadata: 116689
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.trsl.2021.03.016
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33775867; ● Summary page in Scopus @ Elsevier: 2-s2.0-85114290883

(徳島大学機関リポジトリ: 116689, DOI: 10.1016/j.trsl.2021.03.016, PubMed: 33775867, Elsevier: Scopus) Hitoshi Shono, Rie Tsutsumi, Kana Beppu, Rina Matsushima, Suzuno Watanabe, Chisa Fujimoto, Ryo Kanamura, Hiroki Ohnishi, Eiji Kondou, Takahiro Azuma, Gou Satou, Misako Kawai, Hideki Matsumoto, Yoshiaki Kitamura, Hiroshi Sakaue and Noriaki Takeda :
Dietary Supplementation with Monosodium Glutamate Suppresses Chemotherapy-Induced Downregulation of the T1R3 Taste Receptor Subunit in Head and Neck Cancer Patients.,
Nutrients, Vol.13, No.9, 2921, 2021.

(要約): (Background) We investigated the effect of dietary supplementation with monosodium glutamate (MSG) on chemotherapy-induced downregulation of the T1R3 taste receptor subunit expression in the tongue of patients with advanced head and neck cancer. (Methods) Patients undergoing two rounds of chemoradiotherapy were randomly allocated to a control or intervention group (dietary supplementation with MSG at 2.7 g/day during the second round of chemotherapy). The relative expression of T1R3, a subunit of both umami and sweet taste receptors, in the tongue was assessed by quantitative polymerase chain reaction analysis. Dysgeusia was assessed with a visual analog scale and daily energy intake was evaluated. (Results) T1R3 expression levels in the tongue, taste sensitivity, and daily energy intake were significantly reduced after the first round of chemotherapy compared with before treatment. Furthermore, these parameters significantly decreased after the second round of chemotherapy, but the extent of decrease was significantly attenuated in the MSG group compared with the control group. (Conclusions) MSG supplementation suppresses chemotherapy-induced dysgeusia, possibly due to the inhibition of the T1R3-containing taste receptor downregulation in the tongue, thereby increasing energy intake in patients with advanced head and neck cancer.
(キーワード): Adult / Aged / Aged, 80 and over / Antineoplastic Agents / Chemoradiotherapy / Dietary Supplements / Down-Regulation / Dysgeusia / Female / Head and Neck Neoplasms / Humans / Male / Middle Aged / Receptors, G-Protein-Coupled / Sodium Glutamate / Taste / Taste Buds / Tongue
(徳島大学機関リポジトリ): ● Metadata: 117248
(出版サイトへのリンク): ● Publication site (DOI): 10.3390/nu13092921
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34578798; ● Search Scopus @ Elsevier (PMID): 34578798; ● Search Scopus @ Elsevier (DOI): 10.3390/nu13092921

(徳島大学機関リポジトリ: 117248, DOI: 10.3390/nu13092921, PubMed: 34578798) Sachiyo Fukushima, Nobuto Nakanishi, Kazumichi Fujioka, Kenichi Suga, Taku Shirakawa, Kayo Osawa, Kanako Hara, Rie Tsutsumi, Maki Urushihara, Ryuji Nakagawa, Hiroyuki Awano, Jun Oto, Hiroshi Sakaue, Kazumoto Iijima and Masafumi Matsuo :
Assessment of catabolic state in infants with the use of urinary titin N-fragment.,
Pediatric Research, 2021.

(要約): Urinary titin N-fragment levels have been used to assess the catabolic state, and we used this biomarker to evaluate the catabolic state of infants. We retrospectively measured urinary titin N-fragment levels of urinary samples. The primary outcome was its changes according to postmenstrual age. The secondary outcomes included differences between gestational age, longitudinal change after birth, influence on growth, and relationship with blood tests. This study included 219 patients with 414 measurements. Urinary titin N-fragment exponentially declined with postmenstrual age. These values were 12.5 (7.1-19.6), 8.1 (5.1-13.0), 12.8 (6.0-21.3), 26.4 (16.4-52.0), and 81.9 (63.3-106.4) pmol/mg creatinine in full, late, moderate, very, and extremely preterm infants, respectively (p < 0.01). After birth, urinary levels of titin N-fragment exponentially declined, and the maximum level within a week was associated with the time to return to birth weight in preterm infants ( = 0.39, p < 0.01). This was correlated with creatine kinase in full-term infants ( = 0.58, p < 0.01) and with blood urea nitrogen in preterm infants ( = 0.50, p < 0.01). The catabolic state was increased during the early course of the postmenstrual age and early preterm infants. Catabolic state in infants, especially in preterm infants, was expected to be increased, but no study has clearly verified this. In this retrospective study of 219 patients with 414 urinary titin measurements, the catabolic state was exponentially elevated during the early postmenstrual age. The use of the urinary titin N-fragment clarified catabolic state was prominently increased in very and extremely preterm infants.
(出版サイトへのリンク): ● Publication site (DOI): 10.1038/s41390-021-01658-5
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34274960; ● Search Scopus @ Elsevier (PMID): 34274960; ● Search Scopus @ Elsevier (DOI): 10.1038/s41390-021-01658-5

(DOI: 10.1038/s41390-021-01658-5, PubMed: 34274960) Atsushi Morio, Rie Tsutsumi, Takashi Kondo, Hirotsugu Miyoshi, Takahiro Kato, Soshi Narasaki, Shiho Satomi, Erika Nakaya, Masashi Kuroda, Hiroshi Sakaue, Tadahiro Kitamura and Yasuo M. Tsutsumi :
Leucine induces cardioprotection in vitro by promoting mitochondrial function via mTOR and Opa-1 signaling.,
Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, 2021.

(要約): Cardiac myocytes isolated from adult male Wistar rats were incubated and exposed to simulated I/R (SI/R) injury by replacing the air content. Cardiac myocytes were treated with Leu and subsequently, their survival rate was calculated. To elucidate the signaling pathway and mitochondrial function, immunoblots and mitochondrial permeability transition pore were examined. Cell survival rate was decreased with SI/R but improved by 160 μM Leu (38.5 ± 3.6% vs. 64.5 ± 4.2%, respectively, p < 0.001). Although rapamycin (mTOR inhibitor) prevented this cardioprotective effect induced by Leu, wortmannin (PI3K inhibitor) did not interfere with this effect. In addition, we indicated that overexpression of Opa-1 and mitochondrial function are ameliorated via Leu-induced mitochondrial biogenesis. In contrast, knockdown of Opa-1 suppressed Leu-induced cardioprotection.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.numecd.2021.06.025
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34362635; ● Search Scopus @ Elsevier (PMID): 34362635; ● Search Scopus @ Elsevier (DOI): 10.1016/j.numecd.2021.06.025

(DOI: 10.1016/j.numecd.2021.06.025, PubMed: 34362635) Manabu Ishihara, Nobuto Nakanishi, Rie Tsutsumi, Kanako Hara, Kyoka Machida, Nobuaki Yamamoto, Yasuhisa Kanematsu, Hiroshi Sakaue, Jun Oto and Yasushi Takagi :
Elevated Urinary Titin and its Associated Clinical Outcomes after Acute Stroke.,
Journal of Stroke & Cerebrovascular Diseases, Vol.30, No.3, 2021.

(要約): Forty-one patients were included (29 male; age, 68 ± 15 years), 29 had ischemic stroke, 8 had intracerebral hemorrhage, and 4 had subarachnoid hemorrhage. The levels of urinary titin on days 1, 3, 5, and 7 were 9.9 (4.7-21.1), 16.2 (8.6-22.0), 8.9 (4.8-15.2), and 8.7 (3.6-16.2) pmol/mg Cr, respectively. The peak urinary titin level was associated with the mRS score (r = 0.55, p < 0.01), the NIHSS score (r = 0.72, p < 0.01), and the BI (r = -0.59, p < 0.01) upon hospital discharge. In multivariate analysis, the peak urinary titin was associated with poor outcome (p = 0.03).
(キーワード): Aged / Aged, 80 and over / Biomarkers / Connectin / Disability Evaluation / Female / Functional Status / Humans / Male / Middle Aged / Patient Discharge / Predictive Value of Tests / Prospective Studies / Recovery of Function / Stroke / Time Factors / Treatment Outcome / Up-Regulation / Urinalysis
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jstrokecerebrovasdis.2020.105561
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33360523; ● Search Scopus @ Elsevier (PMID): 33360523; ● Search Scopus @ Elsevier (DOI): 10.1016/j.jstrokecerebrovasdis.2020.105561

(DOI: 10.1016/j.jstrokecerebrovasdis.2020.105561, PubMed: 33360523) Yasushi Matsuura, Teruhiro Morishita, Michiko Sato, Nami Sumida, Takafumi Katayama, Rie Tsutsumi, Hiroshi Sakaue, Yutaka Taketani, Koichi Sairyo, Akihiko Kawaura and Eiji Takeda :
Effects of daily 1,000-IU vitamin D-fortified milk intake on skeletal muscle mass, power, physical function and nutrition status in Japanese.,
The Journal of Medical Investigation : JMI, Vol.68, No.3.4, 249-255, 2021.

(要約): An intervention study was conducted to investigate the effects of daily 1,000-IU vitamin D-fortified milk intake on skeletal muscle mass, power, physical function and nutrition status in 26 healthy people and 8 older adults living in a nursing home. The serum 25-hydroxyvitamin D [25(OH)D] level was 13.4 ± 0.8 ng / mL and it markedly increased to 29.6 ± 0.9 ng / mL after daily 1000-IU vitamin D-fortified milk intake for 6 months. Handgrip strength (kg) also significantly increased in the 21-50 years and total groups, and male subjects, and the timed up and go test signiﬁcantly improved in the 21-50 years and total groups, and female subjects after 6-month vitamin D intake. However, there were no significant differences between baseline and post-treatment in the Barthel Index (BI), walking speed (m / sec) or skeletal muscle mass (kg, % of BW, kg / m2). Therefore, the present study suggested that vitamin D-fortified milk intake is effective at improving muscle strength and physical function in Japanese, although further studies are needed, particularly for older adults. J. Med. Invest. 68 : 249-255, August, 2021.
(キーワード): Aged / Animals / 女性 (female) / Hand Strength / Humans / 日本 (Japan) / 男性 (male) / Milk / Muscle Strength / Muscle, Skeletal / Nutritional Status / Postural Balance / Time and Motion Studies / ビタミンD (vitamin D)
(徳島大学機関リポジトリ): ● Metadata: 116490
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.68.249
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34759139; ● Search Scopus @ Elsevier (PMID): 34759139; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.68.249

(徳島大学機関リポジトリ: 116490, DOI: 10.2152/jmi.68.249, PubMed: 34759139) Nobuto Nakanishi, Jun Oto, Rie Tsutsumi, Yusuke Akimoto, Yuki Nakano and Masaji Nishimura :
Upper limb muscle atrophy associated with in-hospital mortality and physical function impairments in mechanically ventilated critically ill adults: a two-center prospective observational study.,
Journal of Intensive Care, Vol.8, No.1, 2020.

(要約): In this two-center prospective observational study, we included adult patients who were expected to require mechanical ventilation for > 48 h and remain in the intensive care unit (ICU) for > 5 days. We used ultrasound to evaluate the cross-sectional area of the biceps brachii on days 1, 3, 5, and 7 and upon ICU discharge along with assessment of physical functions. The primary outcome was the relationship between muscle atrophy ratio and in-hospital mortality on each measurement day, which was assessed using multivariate analysis. The secondary outcomes were the relationships between upper limb muscle atrophy and Medical Research Council (MRC) score, handgrip strength, ICU Mobility Scale (IMS) score, and Functional Status Score for the ICU (FSS-ICU).
(徳島大学機関リポジトリ): ● Metadata: 116553
(出版サイトへのリンク): ● Publication site (DOI): 10.1186/s40560-020-00507-7
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33292655; ● Search Scopus @ Elsevier (PMID): 33292655; ● Search Scopus @ Elsevier (DOI): 10.1186/s40560-020-00507-7

(徳島大学機関リポジトリ: 116553, DOI: 10.1186/s40560-020-00507-7, PubMed: 33292655) Nobuto Nakanishi, Jun Oto, Rie Tsutsumi, Tomoko Yamamoto, Yoshitoyo Ueno, Emiko Nakataki, Taiga Itagaki, Hiroshi Sakaue and Masaji Nishimura :
Effect of Electrical Muscle Stimulation on Upper and Lower Limb Muscles in Critically Ill Patients: A Two-Center Randomized Controlled Trial.,
Critical Care Medicine, Vol.48, No.11, e997-e1003, 2020.

(要約): In critically ill patients, electrical muscle stimulation prevented upper and lower limb muscle atrophy and attenuated proteolysis and decreased the length of hospitalization.
(キーワード): Aged / Amino Acids / Critical Illness / Electric Stimulation Therapy / Extremities / Female / Humans / Male / Muscle, Skeletal / Muscular Atrophy / Quadriceps Muscle / Single-Blind Method
(徳島大学機関リポジトリ): ● Metadata: 115045
(出版サイトへのリンク): ● Publication site (DOI): 10.1097/CCM.0000000000004522
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32897665; ● Search Scopus @ Elsevier (PMID): 32897665; ● Search Scopus @ Elsevier (DOI): 10.1097/CCM.0000000000004522

(徳島大学機関リポジトリ: 115045, DOI: 10.1097/CCM.0000000000004522, PubMed: 32897665) Yuko Okamatsu-Ogura, Masashi Kuroda, Rie Tsutsumi, Ayumi Tsubota, Masayuki Saito, Kazuhiro Kimura and Hiroshi Sakaue :
UCP1-dependent and UCP1-independent metabolic changes induced by acute cold exposure in brown adipose tissue of mice.,
Metabolism: Clinical and Experimental, Vol.113, 154396, 2020.

(要約): These results revealed that cold exposure induces UCP1-mediated thermogenesis-dependent glucose utilization and UCP1-independent active lipid metabolism in BAT. In addition, cold exposure largely affects amino acid metabolism in BAT, especially UCP1-dependently enhances glutamine utilization. These results contribute a comprehensive understanding of UCP1-mediated thermogenesis-dependent and thermogenesis-independent metabolism in BAT.
(キーワード): 褐色脂肪組織 (brown adipose tissue) / Animals / Cold Temperature / 脂肪酸β酸化 (fatty acids β-oxidation) / Glutamine / メタボロミクス (metabolomics) / ノックアウトマウス (knockout mice) / Mice, Inbred C57BL / ノックアウトマウス (knockout mice) / Thermogenesis / Triglycerides / Uncoupling Protein 1
(徳島大学機関リポジトリ): ● Metadata: 116598
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.metabol.2020.154396
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33065161; ● Search Scopus @ Elsevier (PMID): 33065161; ● Search Scopus @ Elsevier (DOI): 10.1016/j.metabol.2020.154396

(徳島大学機関リポジトリ: 116598, DOI: 10.1016/j.metabol.2020.154396, PubMed: 33065161) Nobuto Nakanishi, Rie Tsutsumi, Kanako Hara, Takuya Takashima, Emiko Nakataki, Taiga Itagaki, Masafumi Matsuo, Jun Oto and Hiroshi Sakaue :
Urinary Titin Is a Novel Biomarker for Muscle Atrophy in Nonsurgical Critically Ill Patients: A Two-Center, Prospective Observational Study.,
Critical Care Medicine, Vol.2020, No.48(9), 1327-1333, 2020.

(要約): In nonsurgical critically ill patients, urinary titin level increased 10-30 times compared with the normal level. The increased urinary titin level was associated with lower limb muscle atrophy, occurrence of ICU-acquired weakness, and ICU mortality.
(徳島大学機関リポジトリ): ● Metadata: 115044
(出版サイトへのリンク): ● Publication site (DOI): 10.1097/CCM.0000000000004486
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32706557; ● Summary page in Scopus @ Elsevier: 2-s2.0-85089802708

(徳島大学機関リポジトリ: 115044, DOI: 10.1097/CCM.0000000000004486, PubMed: 32706557, Elsevier: Scopus) Yumiko Miyatake, Yuna Mishima, Rie Tsutsumi, Tamaki Otani, Naoya Suemasa, Saeko Masumoto, Masashi Kuroda and Hiroshi Sakaue :
Assessment of insulin resistance in the skeletal muscle of mice using positron emission tomography/computed tomography imaging.,
Biochemical and Biophysical Research Communications, Vol.528, No.3, 499-505, 2020.

(要約): Measuring glucose uptake in the skeletal muscle in vivo is an effective method to determine glucose metabolism abnormalities as the skeletal muscle is the principal tissue responsible for glucose disposal and is a major site of peripheral insulin resistance. In this study, we investigated the pathological glucose metabolism dynamics of the skeletal muscle of C57BL/6J mice in a noninvasive and time-sequential manner using positron emission tomography/computed tomography (PET/CT), an imaging technique that uses radioactive substances to visualize and measure metabolic processes in the body, with [
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.bbrc.2020.05.165
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32513534; ● Search Scopus @ Elsevier (PMID): 32513534; ● Search Scopus @ Elsevier (DOI): 10.1016/j.bbrc.2020.05.165

(DOI: 10.1016/j.bbrc.2020.05.165, PubMed: 32513534) Nagakatsu Harada, Yuka Gotoda, Adzumi Hatakeyama, Tadahiko Nakagawa, Yumiko Miyatake, Masashi Kuroda, Saeko Masumoto, Rie Tsutsumi, Yutaka Nakaya and Hiroshi Sakaue :
Differential regulation of Actn2 and Actn3 expression during unfolded protein response in C2C12 myotubes.,
Journal of Muscle Research and Cell Motility, 2020.

(要約): ACTN2 and ACTN3 encode sarcomeric α-actinin-2 and α-actinin-3 proteins, respectively, that constitute the Z-line in mammalian skeletal muscle fibers. In human ACTN3, a nonsense mutation at codon 577 that encodes arginine (R) produces the R577X polymorphism. Individuals having a homozygous 577XX genotype do not produce α-actinin-3 protein. The 577XX genotype reportedly occurs in sprint and power athletes in frequency lower than in the normal population, suggesting that α-actinin-3 deficiency diminishes fast-type muscle function. Among humans who carry 577R alleles, varying ACTN3 expression levels under certain conditions can have diverse effects on atheletic and muscle performance. However, the factors that regulate ACTN3 expression are unclear. Here we investigated whether the unfolded protein response (UPR) under endoplasmic reticulum (ER) stress regulates expression of Actn3 and its isoform Actn2 in mouse C2C12 myotubes. Among UPR-related transcription factors, XBP1 upregulated Actn2, whereas XBP1, ATF4 and ATF6 downregulated Actn3 promoter activity. Chemical induction of ER stress increased Actn2 mRNA levels, but decreased those for Actn3. ER stress also decreased α-actinin-3 protein levels, whereas levels of α-actinin-2 were unchanged. The intracellular composition of muscle contraction-related proteins was altered under ER stress, in that expression of parvalbumin (a fast-twitch muscle-specific protein) and troponin I type 1 (skeletal, slow) was suppressed. siRNA-induced suppression of Actn3 mimicked the inhibitory effect of ER stress on parvalbumin levels. Thus, endogenous expression levels of α-actinin-3 can be altered by ER stress, which may modulate muscle performance and athletic aptitudes, particularly in humans who carry ACTN3 577R alleles.
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s10974-020-09582-7
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32451822; ● Search Scopus @ Elsevier (PMID): 32451822; ● Search Scopus @ Elsevier (DOI): 10.1007/s10974-020-09582-7

(DOI: 10.1007/s10974-020-09582-7, PubMed: 32451822) Masashi Kuroda, Misa Nishiguchi, Naho Ugawa, Etsuko Ishikawa, Yasuyo Kawabata, Saya Okamoto, Waka Sasaki, Yumiko Miyatake, Mayu Sebe, Saeko Masumoto, Rie Tsutsumi, Nagakatsu Harada and Hiroshi Sakaue :
Interferon regulatory factor 7 mediates obesity-associated MCP-1 transcription.,
PLoS ONE, Vol.15, No.5, e0233390, 2020.

(要約): Hypertrophy, associated with adipocyte dysfunction, causes increased pro-inflammatory adipokine, and abnormal glucose and lipid metabolism, leading to insulin resistance and obesity-related-health problems. By combining DNA microarray and genomic data analyses to predict DNA binding motifs, we identified the transcription factor Interferon Regulatory Factor 7 (IRF7) as a possible regulator of genes related to adipocyte hypertrophy. To investigate the role of IRF7 in adipocytes, we examined gene expression patterns in 3T3-L1 cells infected with a retrovirus carrying the IRF7 gene and found that enforced IRF7 expression induced the expression of monocyte chemoattractant protein-1 (MCP-1), a key initial adipokine in the chronic inflammation of obesity. CRISPR/Cas9 mediated-suppression of IRF7 significantly reduced MCP-1 mRNA. Luciferase assays, chromatin immunoprecipitation PCR analysis and gel shift assay showed that IRF7 transactivates the MCP-1 gene by binding to its proximal Interferon Stimulation Response Element (ISRE), a putative IRF7 binding motif. IRF7 knockout mice exhibited lower expression of MCP-1 in epidydimal white adipose tissue under high-fat feeding conditions, suggesting the transcription factor is physiologically important for inducing MCP-1. Taken together, our results suggest that IRF7 transactivates MCP-1 mRNA in adipocytes, and it may be involved in the adipose tissue inflammation associated with obesity.
(徳島大学機関リポジトリ): ● Metadata: 115245
(出版サイトへのリンク): ● Publication site (DOI): 10.1371/journal.pone.0233390
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32437400; ● Search Scopus @ Elsevier (PMID): 32437400; ● Search Scopus @ Elsevier (DOI): 10.1371/journal.pone.0233390

(徳島大学機関リポジトリ: 115245, DOI: 10.1371/journal.pone.0233390, PubMed: 32437400) Masashi Kuroda, Rumi Onoyama, Waka Sasaki, Mayu Sebe, Tadahiro Kitamura, Saeko Masumoto, Rie Tsutsumi, Nagakatsu Harada and Hiroshi Sakaue :
DNA methylation status influences insulin-induced glucose transport in 3T3-L1 adipocytes by mediating p53 expression.,
Biochemical and Biophysical Research Communications, Vol.525, No.1, 39-45, 2020.

(要約): Researchers frequently use 3T3-L1 adipocytes as a fat cell line, but the capacity of this line for insulin-mediated glucose transport is lower than that of primary isolated fat cells. In this study, we found that 5-azacytidine (5-aza-C), DNA methyltransferase 1 inhibitor, enhanced insulin-stimulated 2-deoxyglucose (2-DG) transport in 3T3-L1 cells after adipogenic differentiation. We next examined the expression of the genes related to glucose transport and insulin signal transduction. The insulin independent glucose transporter, glucose transporter 1 (GLUT1), showed lower expression in 5-aza-C pre-treated 3T3-L1 adipocytes, than in un-treated control adipocytes, while the expression of insulin dependent transporter GLUT4 remained unchanged. In addition, insulin receptor substrate-1 (IRS-1) was highly expressed in 5-aza-C pre-treated adipocytes. Based on DNA microarray and functional annotation analysis, we noticed that 5-aza-C pretreatment activated the tumor suppressor p53 pathway. We confirmed that in 5-aza-C adipocytes, p53 expression was markedly higher, and the methylation level of CpGs in its promoter region was lower than in un-treated control adipocytes. Moreover, pharmacological inhibition of p53 restored GLUT1 and IRS-1 expression to the same level as in un-treated 3T3-L1 adipocytes, and significantly decreased insulin-mediated 2-DG uptake. These results suggest that glucose transport capacity in adipocytes is influenced by DNA methylation status, and demethylation induced by 5-aza-C increased it possibly through the p53 signaling pathway.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.bbrc.2020.02.038
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32070490; ● Search Scopus @ Elsevier (PMID): 32070490; ● Search Scopus @ Elsevier (DOI): 10.1016/j.bbrc.2020.02.038

(DOI: 10.1016/j.bbrc.2020.02.038, PubMed: 32070490) Nobuto Nakanishi, Rie Tsutsumi, Yoshihiro Okayama, Takuya Takashima, Yoshitoyo Ueno, Taiga Itagaki, Yasuo Tsutsumi, Hiroshi Sakaue and Jun Oto :
Monitoring of muscle mass in criticaly ill patients: comparison of ultrasound and two bioelectrical impedance analysis devices,
Journal of Intensive Care, Vol.7, 61, 2020.

(要約): Skeletal muscle atrophy commonly occurs in critically ill patients, and decreased muscle mass is associated with worse clinical outcomes. Muscle mass can be assessed using various tools, including ultrasound and bioelectrical impedance analysis (BIA). However, the effectiveness of muscle mass monitoring is unclear in critically ill patients. This study was conducted to compare ultrasound and BIA for the monitoring of muscle mass in critically ill patients. We recruited adult patients who were expected to undergo mechanical ventilation for > 48 h and to remain in the intensive care unit (ICU) for > 5 days. On days 1, 3, 5, 7, and 10, muscle mass was evaluated using an ultrasound and two BIA devices (Bioscan: Malton International, England; Physion: Nippon Shooter, Japan). The influence of fluid balance was also evaluated between each measurement day. We analyzed 93 images in 21 patients. The age of the patients was 69 (interquartile range, IQR, 59-74) years, with 16 men and 5 women. The length of ICU stay was 11 days (IQR, 9-25 days). The muscle mass, monitored by ultrasound, decreased progressively by 9.2% (95% confidence interval (CI), 5.9-12.5%), 12.7% (95% CI, 9.3-16.1%), 18.2% (95% CI, 14.7-21.6%), and 21.8% (95% CI, 17.9-25.7%) on days 3, 5, 7, and 10 ( < 0.01), respectively, with no influence of fluid balance ( = 0.04, = 0.74). The muscle mass did not decrease significantly in both the BIA devices (Bioscan, = 0.14; Physion, = 0.60), and an influence of fluid balance was observed (Bioscan, = 0.37, < 0.01; Physion, = 0.51, < 0.01). The muscle mass assessment at one point between ultrasound and BIA was moderately correlated (Bioscan, = 0.51, < 0.01; Physion, = 0.37, < 0.01), but the change of muscle mass in the same patient did not correlate between these two devices (Bioscan, = - 0.05, = 0.69; Physion, = 0.23, = 0.07). Ultrasound is suitable for sequential monitoring of muscle atrophy in critically ill patients. Monitoring by BIA should be carefully interpreted owing to the influence of fluid change. UMIN000031316. Retrospectively registered on 15 February 2018.
(キーワード): 超音波 (ultrasound) / Bioelectrical impedance analysis / 筋萎縮 (muscle atrophy)
(徳島大学機関リポジトリ): ● Metadata: 114541
(出版サイトへのリンク): ● Publication site (DOI): 10.1186/s40560-019-0416-y
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31890223; ● Summary page in Scopus @ Elsevier: 2-s2.0-85077117012

(徳島大学機関リポジトリ: 114541, DOI: 10.1186/s40560-019-0416-y, PubMed: 31890223, Elsevier: Scopus) Shiho Satomi, Atsushi Morio, Hirotsugu Miyoshi, Ryuji Nakamura, Rie Tsutsumi, Hiroshi Sakaue, Toshimichi Yasuda, Noboru Saeki and Yasuo M. Tsutsumi :
Branched-chain amino acids-induced cardiac protection against ischemia/reperfusion injury.,
Life Sciences, Vol.245, 2020.

(要約): Mice treated with BCAAs had a significant reduction in infarct size as a percentage of the area at risk compared to controls (34.1 ± 3.9% vs. 44.7 ± 2.6%, P = 0.001), whereas mice treated with the mTOR inhibitor rapamycin were not protected by BCAA administration (42.2 ± 6.5%, vs. control, P = 0.015). This protection was not detected in our hetero knockout mice of mTOR. Western blot analysis revealed no change in AKT signaling whereas activation of mTOR was identified. Furthermore, BCAAs prevented swelling which was reversed by the addition of rapamycin. In myocytes undergoing simulated I/R, BCAA treatment significantly preserved cell viability (71.7 ± 2.7% vs. 34.5 ± 1.6%, respectively, p < 0.0001), whereas rapamycin prevented this BCAA-induced cardioprotective effect (43.5 ± 3.4% vs. BCAA, p < 0.0001).
(キーワード): Amino Acids, Branched-Chain / Animals / Blotting, Western / Cardiotonic Agents / Disease Models, Animal / Male / Mice / Mice, Inbred C57BL / Mice, Knockout / Myocardial Reperfusion Injury / Myocytes, Cardiac / Rats / Rats, Wistar / Sirolimus / TOR Serine-Threonine Kinases
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.lfs.2020.117368
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32001270; ● Summary page in Scopus @ Elsevier: 2-s2.0-85078659582

(DOI: 10.1016/j.lfs.2020.117368, PubMed: 32001270, Elsevier: Scopus) Mayu Sebe, Rie Tsutsumi, Takuro Oyama, T Yousuke Horikawa, Yuta Uemura, Nami Kakuta, Yoko Sakai, Atsushi Morio, Hirotsugu Miyoshi, Takashi Kondo, Tomoaki Urabe, Yuko Noda, Satoshi Kamiya, Noboru Saeki, Masashi Kuroda, Katsuya Tanaka, Yasuo Tsutsumi and Hiroshi Sakaue :
Assessment of postoperative nutritional status and physical function between open surgical aortic valve replacement and transcatheter aortic valve implantation in elderly patients.,
The Journal of Medical Investigation : JMI, Vol.67, No.1.2, 139-144, 2020.

(要約): Background and aims : Severe aortic stenosis (AS) has been normally treated with surgical aortic valve replacement (AVR) whereas recently, transcatheter aortic valve implantation (TAVI) has been introduced as a minimally invasive operation for patients with high surgical risk and frailty. In this study, we have evaluated postoperative physical function and nutrition intake in the patients following AVR and TAVI. Methods : This prospective observational study involved 9 patients with surgical aortic valve replacement (AVR) and 7 patients with transcatheter aortic valve implantation (TAVI). Body composition was measured one day prior surgery, postoperative day (POD) 1, POD 3, POD 5 and POD 7. Hand grip strength, calf circumference and gait speed were measured one day before surgery and on the day of discharge. Results : Skeletal muscle was significantly decreased in AVR patients at postoperative day 3 and 7, while there was no change in TAVI patients. Patients with TAVI showed higher dietary intake after surgery compared to patients with AVR, and they maintained hand grip strength and calf circumference at discharge. Conclusions : In elderly patients with AS, TAVI can improve post-operative recovery maintaining nutritional status and physical function even. J. Med. Invest. 67 : 139-144, February, 2020.
(徳島大学機関リポジトリ): ● Metadata: 114644
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.67.139
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32378597; ● Search Scopus @ Elsevier (PMID): 32378597; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.67.139

(徳島大学機関リポジトリ: 114644, DOI: 10.2152/jmi.67.139, PubMed: 32378597) Abhishek Shetty, Thejaswini Venkatesh, Rie Tsutsumi and S Padmanaban Suresh :
Gene expression changes and promoter methylation with the combined effects of estradiol and leptin in uterine tissue of the ovariectomized mice model of menopause.,
Molecular Biology Reports, Vol.47, No.1, 151-168, 2019.

(要約): Substantial epidemiological studies have shown an association of obesity with the common gynecological malignancy, endometrial cancer. The relevant interactions and contribution of estradiol and the adipose cytokine, leptin, in endometrial lesions are not completely understood. Suitable animal models to understand the physiological response of uterine tissue to the combined effects of estradiol-leptin are lacking. To investigate the effect of estradiol-leptin crosstalk on gene expression and associated altered pathways, we established an ovariectomized mouse model, treated with 17-β estradiol (0.1 µg/mouse subcutaenously., for every 12 h) and/or recombinant mouse leptin (1 μg/g Bwt intraperitoneally., for every 12 h) for 4 h, 20 h, and 40 h. Gene expressions by semi-quantitative RT-PCR, uterine tissue protein phosphorylation status by western blotting and promoter methylation were analyzed in estradiol, progesterone insufficient animals. Semi-quantitative RT-PCR demonstrated significantly increased expression of Esr, Igf1, Igfbp3, Vegfr1, and Vegf, and significantly decreased expression of Mmp9 after co-treatment with estradiol and leptin, indicating a common transcriptional network regulated by the treatments. Ovariectomy-induced histomorphological changes were only reversed by estradiol. Methylation-specific PCR, analyzing methylation of CpG sites of Vegfa, Pgr, and Igf1, revealed that transcriptional regulation after hormonal treatments is independent of methylation at the examined CpG sites. Western blot confirmed the increased expression of PSTAT-3 (Ser-727) and PERK1/2 proteins after estradiol + leptin treatment, confirming the estradiol + leptin cross-talk hypothesis. In conclusion, our in vivo studies determined specific gene expression and signaling protein changes, and further unraveled the molecular targets of estradiol + leptin that may perturb endometrial homeostasis and lead to endometrial hyperplasia development in the chronic stimulated state.
(キーワード): Animals / DNA Methylation / Drug Combinations / Endometrium / Estradiol / Female / Gene Expression Regulation / Leptin / Menopause / Mice / Models, Animal / Ovariectomy / Promoter Regions, Genetic / Uterus
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s11033-019-05116-8
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31602590; ● Summary page in Scopus @ Elsevier: 2-s2.0-85074054627

(DOI: 10.1007/s11033-019-05116-8, PubMed: 31602590, Elsevier: Scopus) Abhishek Shetty, Thejaswini Venkatesh, Rie Tsutsumi and S Padmanaban Suresh :
Regulated expression of Gemin5, Xrn1, Cpeb and Stau1 in the uterus and ovaries after superovulation and the effect of exogenous estradiol and leptin in rodents.,
Molecular Biology Reports, Vol.46, No.2, 2533-2540, 2019.

(要約): The aim of this study was to evaluate whether Gemin 5, Cpeb, Xrn1, and Stau1 expression in rodent ovaries and uterine tissues is dependent on gonadotropins, steroid hormones, and leptin in the superovulation and ovariectomized mouse models of menopause. Treatment of pregnant mare serum gonadotropin-primed rats with human chorionic gonadotropin (hCG) significantly induced Stau1 and Gemin 5 messenger RNA expression in rat ovaries. Gemin 5 expression in ovaries was sustained at relatively high levels at 12 h and 24 h post hCG treatment compared to Stau1, suggesting its role in follicle development, ovulation, and luteogenesis in rat ovaries. Induced expression of Stau1 and Gemin 5 in the uterine tissue post hCG treatment at 12 h and 24 h-the duration between ovulation and post-ovulation-suggests their regulation by hCG and/or ovarian steroids, which are required for pregnancy establishment and maintenance. Cpeb expression was significantly higher (p < 0.05) in the uterine tissues after combined treatment of estradiol and leptin at 4 h. Further, the significant upregulation of uterine Gemin 5 and Xrn1 by the synergistic activities of leptin and estradiol at 40 h in ovariectomized mice establishes them as targets of cross-talk. Although these are preliminary data, the combination of Gemin 5, Cpeb, Xrn1, and Stau1 transcript alterations in rodent ovaries and uterine tissue displayed in two different experimental models underscore their importance as therapeutic targets for anovulation or in overcoming endometrial homeostasis disturbances during pregnancy due to obesity.
(キーワード): Animals / Chorionic Gonadotropin / Cytoskeletal Proteins / Estradiol / Exoribonucleases / Female / Gene Expression Regulation / Leptin / Microtubule-Associated Proteins / Ovariectomy / Ovary / Progesterone / RNA-Binding Proteins / Rats / Rats, Wistar / SMN Complex Proteins / Superovulation / Uterus / mRNA Cleavage and Polyadenylation Factors
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s11033-019-04606-z
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30689188; ● Search Scopus @ Elsevier (PMID): 30689188; ● Search Scopus @ Elsevier (DOI): 10.1007/s11033-019-04606-z

(DOI: 10.1007/s11033-019-04606-z, PubMed: 30689188) Mari Miki, Susumu Yasuoka, Rie Tsutsumi, Yoichi Nakamura, Maeda Hajime, Yukiyasu Takeuchi, Keisuke Miki, Seigo Kitada and Ryoji Maekura :
Human airway trypsin-like protease enhances interleukin-8 synthesis in bronchial epithelial cells by activating protease-activated receptor 2.,
Archives of Biochemistry and Biophysics, Vol.664, 167-173, 2019.

(要約): Human airway trypsin-like protease (HAT) localizes at human bronchial epithelial cells (HBECs). HAT enhanced release of interleukin-8 (IL-8) from HBECs at 10-100 mU/mL and the enhanced release was almost completely abolished by 50 μM leupeptin, a serine protease inhibitor. Previous reports suggested that HAT displays its physiological functions via protease-activated receptor 2 (PAR2). In the present study, we examined the mechanism whereby HAT upregulates IL-8 synthesis in HBECs with a focus on PAR2. Northern blot analysis revealed that HAT enhanced IL-8 mRNA expression at concentrations of 10-100 mU/mL. PAR2 activating peptide (PAR2 AP) also enhanced IL-8 release and IL-8 mRNA expression in HBECs at 50-1,000 μM at similar levels as HAT. Knockdown of PAR2 mRNA by siRNA methods showed that PAR2 mRNA expression was significantly depressed in primary HBECs, and both HAT- and PAR2 AP-induced IL-8 mRNA elevation was significantly depressed in PAR2 siRNA-transfected HBECs. Additionally, HAT cleaved the PAR2 activating site (R
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.abb.2019.01.019
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30677406; ● Summary page in Scopus @ Elsevier: 2-s2.0-85061745596

(DOI: 10.1016/j.abb.2019.01.019, PubMed: 30677406, Elsevier: Scopus) Masahiro Bando, Saeko Masumoto, Masashi Kuroda, Rie Tsutsumi and Hiroshi Sakaue :
Effect of olive oil consumption on aging in a senescence-accelerated mice-prone 8 (SAMP8) model.,
The Journal of Medical Investigation : JMI, Vol.66, No.3.4, 241-247, 2019.

(要約): Background : Mediterranean diets have been linked to a reduced risk of cancer, vascular illnesses, Parkinson's and Alzheimer's disease. Olive oil is the primary fat source in the Mediterranean diet ; however, only a few studies have investigated the effect of olive oil on aging. In the present study, we aimed to determine whether consumption of olive oil significantly influences aging and memory in senescence-accelerated mouse-prone 8 (SAMP8). Methods : SAMP8 and senescence-accelerated mouse resistant 1 (SAMR1) mice were fed either 7% soy oil or 1% olive oil and 6% soy oil during a six-month study period. Reduction in memory in passive avoidance learning was examined after two months from the initiation of the experiment. Results : The weight of organs including the liver, kidney, spleen, and fat tissue changed significantly and memory performance was reduced in SAMP8 than in SAMR1 mice. There were no significant differences in SAMP8 and SAMR1 mice; however, blood triglyceride level decreased significantly in SAMP8 mice fed on olive oil. Conclusions : These results suggest that consuming olive oil may not have a protective role in aging and memory recall, but beneficial effects may be related to improvement in lipid metabolism. J. Med. Invest. 66 : 241-247, August, 2019.
(キーワード): 加齢 (aging) / Animals / Avoidance Learning / Diet, Mediterranean / 記憶 (memory) / Mice / Models, Animal / Olive Oil / Organ Size / Triglycerides
(徳島大学機関リポジトリ): ● Metadata: 113365
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.66.241
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31656282; ● Summary page in Scopus @ Elsevier: 2-s2.0-85074168190

(徳島大学機関リポジトリ: 113365, DOI: 10.2152/jmi.66.241, PubMed: 31656282, Elsevier: Scopus) 堤理恵, 瀬部真由, 別府香名, 渡辺涼乃, 尾平優, 黒田雅士, 阪上浩 :
化学療法に伴う味覚・嗅覚障害への対応 (特集化学療法時の栄養管理),
日本静脈経腸栄養学会雑誌, Vol.33, No.4, 1019-1024, 2018年.

(要約): <p>がんの化学療法中に味覚・嗅覚障害は頻繁に生じ，患者のquality of life(以下，QOLと略)だけでなく，体重低下や栄養状態の悪化を引き起こす深刻な副作用である．しかしながらこれまで確立された治療法や予防策はなく，食事内容や形態の工夫が主な対処法であった．味覚障害は薬剤による亜鉛のキレート化が原因であるとされているが，これに加えて味覚受容体遺伝子の発現変化や口腔粘膜障害の影響も報告されている．本稿では，化学療法中に生じる味覚・嗅覚障害の実態とともに，これに対する栄養的なアプローチを紹介する．</p>
(キーワード): 味覚障害 / 嗅覚障害 / 化学療法
(徳島大学機関リポジトリ): ● Metadata: 113717
(出版サイトへのリンク): ● Publication site (DOI): 10.11244/jspen.33.1019
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390282763059771520; ● Search Scopus @ Elsevier (DOI): 10.11244/jspen.33.1019

(徳島大学機関リポジトリ: 113717, DOI: 10.11244/jspen.33.1019, CiNii: 1390282763059771520) Nagakatsu Harada, Adzumi Hatakeyama, Maiko Okuyama, Yumiko Miyatake, Tadahiko Nakagawa, Masashi Kuroda, Saeko Masumoto, Rie Tsutsumi, Yutaka Nakaya and Hiroshi Sakaue :
Readthrough of ACTN3 577X nonsense mutation produces full-length α-actinin-3 protein.,
Biochemical and Biophysical Research Communications, Vol.502, No.3, 422-428, 2018.

(要約): , respectively) and transfected the constructs into HEK293 cells. Similar constructs for the ACTN3 577R gene were used as controls. HEK293 cells carrying the X gene, but not the X
(キーワード): Actinin / Caffeine / Codon, Nonsense / Gentamicins / HEK293 Cells / Humans / Muscle, Skeletal / Mutant Proteins / Peptide Chain Termination, Translational / RNA Stability / RNA, Messenger / Transfection
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.bbrc.2018.05.193
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29857001; ● Search Scopus @ Elsevier (PMID): 29857001; ● Search Scopus @ Elsevier (DOI): 10.1016/j.bbrc.2018.05.193

(DOI: 10.1016/j.bbrc.2018.05.193, PubMed: 29857001) S Padmanaban Suresh, Rie Tsutsumi and Thejaswini Venkatesh :
YBX1 at the crossroads of non-coding transcriptome, exosomal, and cytoplasmic granular signaling.,
European Journal of Cell Biology, Vol.97, No.3, 163-167, 2018.

(要約): YBX1 (Y box binding protein 1) is an RNA-/DNA-binding multifunctional protein harboring the classical cold shock protein (CSD) domain, an A/P domain, and a long C-terminal domain with alternating positively and negatively charged amino acids. It is a well-established oncogenic transcriptional factor, and regulates apoptosis, translation, cell proliferation, mRNA splicing, repair, differentiation, and stress response. The non-coding transcriptome has added yet another layer of complexity to the YBX1-mediated master regulation of cellular functions. Interestingly, YBX1 has been shown to localize to cytoplasmic granules such as P granules and stress granules. These granules regulate the non-coding transcriptome profile as well as mRNA translation and degradation. In this review, we discuss the recent findings on YBX1 signaling as mediated by various classes of non-coding RNAs, and on the functions of YBX1 at P granules, stress granules, exosomes, and mitochondria. YBX1 is a well-established target for cancer therapy and understanding its functions at organelles and ncRNA transcriptomes will shed new insights for devising organelle based anti-cancer therapies.
(キーワード): Animals / Cytoplasmic Granules / Exosomes / Humans / RNA, Untranslated / Signal Transduction / Transcriptome / Y-Box-Binding Protein 1
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.ejcb.2018.02.003
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29478751; ● Search Scopus @ Elsevier (PMID): 29478751; ● Search Scopus @ Elsevier (DOI): 10.1016/j.ejcb.2018.02.003

(DOI: 10.1016/j.ejcb.2018.02.003, PubMed: 29478751) 福永佳容子, 堤理恵 :
Q&A 蛋白源としてのペプチドの意義 (特集エキスパートに学ぶ栄養管理のすべて),
救急·集中治療, Vol.30, No.1, 79-85, 2018年.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1573950786547852416

(CiNii: 1573950786547852416) Susumu Yasuoka, Mari Miki, Rie Tsutsumi, Masami Yoshioka, Takashi Bando and Fumiko Michishige :
Human airway trypsin-like protease (HAT) is released into saliva.,
The Journal of Medical Investigation : JMI, Vol.65, No.3.4, 258-267, 2018.

(要約): We first discovered human airway trypsin-like protease (HAT) in human mucoid sputum. Precursor HAT (47 kDa), a cell surface type Ⅱ transmembrane serine protease, is proteolyzed to mature HAT (27 kDa). Hitherto, HAT has not been detected in other biological fluids except for human sputum. We aimed to clarify whether human saliva contains mature HAT. Trypsin-like protease was isolated from saliva of healthy volunteers by a method adopted for isolation of HAT from sputum using Boc-Phe-Ser-Arg-MCA as the substrate. Biochemical properties of purified protease were similar to those of recombinant HAT (rHAT). HAT concentration in saliva was measured by ELISA, and immunoreactive HAT:total protein ratio (ng/mg) in saliva samples from healthy subjects was similar to that in mucoid sputum. RT-PCR showed that HAT mRNA was expressed in human gingival epithelial cells but not in gingival fibroblasts. Both indirect immunofluorescence and western blotting using monoclonal antibody for α-smooth muscle actin (α-SMA;a myofibroblast marker) showed that HAT enhanced α-SMA fiber expression in gingival fibroblasts. These results indicate that both mucoid sputum and saliva from healthy subjects have similar concentrations of mature HAT, and HAT is related to certain physiological functions and pathological states of myofibroblasts in the oral cavity. J. Med. Invest. 65:258-267, August, 2018.
(キーワード): Actins / Adult / Cells, Cultured / Epithelial Cells / Female / Fibroblasts / Gingiva / Healthy Volunteers / Humans / Middle Aged / RNA, Messenger / Saliva / Serine Endopeptidases / Sputum / Young Adult
(徳島大学機関リポジトリ): ● Metadata: 112270
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.65.258
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30282870; ● Search Scopus @ Elsevier (PMID): 30282870; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.65.258

(徳島大学機関リポジトリ: 112270, DOI: 10.2152/jmi.65.258, PubMed: 30282870) Chikugo Momoko, Sebe Mayu, Rie Tsutsumi, Iuchi Marina, Jun Kishi, Masashi Kuroda, Nagakatsu Harada, Yasuhiko Nishioka and Hiroshi Sakaue :
Effect of Janus kinase inhibition by tofacitinib on body composition and glucose metabolism.,
The Journal of Medical Investigation : JMI, Vol.65, No.3.4, 166-170, 2018.

(要約): Tofacitinib is the first Janus Kinase (JAK) inhibitor to treat moderately to severely active RA. In this study, we investigated whether the effect of tofacitinib have any effects on body composition in mice and female patients with RA. Female C57BL/6 mice fed with a high-fat diet were treated with 30 mg/kg/day tofacitinib or vehicle for 70 days. Following treatment, trunk muscle, subcutaneous fat, and visceral fats were measured using X-ray computed tomography CT scan. Glucose tolerance and insulin sensitivity were assessed. In female RA patients treated with biological disease modified anti-rheumatic-drugs (biological DMARDs) or tofacitinib (n=4 per group), we also evaluated the body composition after 3 months from the start of treatment initiation using bioelectrical impedance analysis. Treatment with tofacitinib did not affect the body weight, and body composition in C57BL/6 mice. It also did not affect glucose, and insulin tolerance in mice. In patients with RA, treatment with biological DMARDs did not affect the body composition whereas the muscle mass was unchanged after receiving tofacitinib and the fat mass was significantly increased. J. Med. Invest. 65:166-170, August, 2018.
(徳島大学機関リポジトリ): ● Metadata: 112232
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.65.166
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30282855; ● Search Scopus @ Elsevier (PMID): 30282855; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.65.166

(徳島大学機関リポジトリ: 112232, DOI: 10.2152/jmi.65.166, PubMed: 30282855) Rodrigo Scotini, Ian Skinner, Francesca Racioppi, Virginia Fusé, Oliveira Jonas de Bertucci and Rie Tsutsumi :
Supporting Active Mobility and Green Jobs through the Promotion of Cycling.,
International Journal of Environmental Research and Public Health, Vol.14, No.12, 2017.

(要約): This article is a summary of the main findings of the study "Riding towards the green economy: cycling and green jobs", which was developed in the context of the Transport, Health and Environment pan-European Programme (THE PEP). It builds on previous work under THE PEP, which demonstrated the job creation potential of cycling and of green and healthy transport more generally. The report summarized in this article collected data on jobs associated with cycling directly from city authorities and analysed these to re-assess previous estimates of the job creation potential of cycling. It concluded that the number of cycling-related jobs in the pan-European Region could increase by 435,000 in selected major cities if they increased their cycling share to that of the Danish capital Copenhagen. The implications and potential role of municipal and sub-national authorities in facilitating cycling while supporting economic development are then discussed. These findings indicate that investment in policies that promote cycling could deliver not only important benefits for health, the environment and the quality of urban life, but could also contribute to a sizable creation of job opportunities. Authorities need to be proactive in promoting cycling in order to deliver these benefits.
(キーワード): Bicycling / Employment / Europe / European Union / Humans
(徳島大学機関リポジトリ): ● Metadata: 113713
(出版サイトへのリンク): ● Publication site (DOI): 10.3390/ijerph14121603
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29257121; ● Search Scopus @ Elsevier (PMID): 29257121; ● Search Scopus @ Elsevier (DOI): 10.3390/ijerph14121603

(徳島大学機関リポジトリ: 113713, DOI: 10.3390/ijerph14121603, PubMed: 29257121) Nobuto Nakanishi, Jun Oto, Rie Tsutsumi, Marina Iuchi, Mutsuo Onodera and Masaji Nishimura :
Upper and lower limb muscle atrophy in critically ill patients: an observational ultrasonography study.,
Intensive Care Medicine, Vol.44, No.2, 263-264, 2017.

(徳島大学機関リポジトリ): ● Metadata: 113714
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s00134-017-4975-x
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29110031; ● Summary page in Scopus @ Elsevier: 2-s2.0-85033478769

(徳島大学機関リポジトリ: 113714, DOI: 10.1007/s00134-017-4975-x, PubMed: 29110031, Elsevier: Scopus) Nagakatsu Harada, Maiko Okuyama, Aya Yoshikatsu, Hironori Yamamoto, Saori Ishiwata, Chikako Hamada, Tomoyo Hirose, Masayuki Shono, Masashi Kuroda, Rie Tsutsumi, Jiro Takeo, Yutaka Taketani, Yutaka Nakaya and Hiroshi Sakaue :
Endoplasmic Reticulum Stress in Mice Increases Hepatic Expression of Genes Carrying a Premature Termination Codon via a Nutritional Status-Independent GRP78-Dependent Mechanism.,
Journal of Cellular Biochemistry, Vol.118, No.11, 3810-3824, 2017.

(出版サイトへのリンク): ● Publication site (DOI): 10.1002/jcb.26031
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28383761; ● Search Scopus @ Elsevier (PMID): 28383761; ● Search Scopus @ Elsevier (DOI): 10.1002/jcb.26031

(DOI: 10.1002/jcb.26031, PubMed: 28383761) Yasuo Tsutsumi, Takuro Oyama, Nami Kakuta, YT Horikawa, Katsuyoshi Kume, Yoko Sakai, Rie Tsutsumi and Katsuya Tanaka :
Effect of oral carbohydrate with amino acid solution on serum oxidative/anti-oxidative status in healthy volunteers.,
Journal of Anesthesia, Vol.31, No.3, 472-475, 2017.

(要約): The aim of this work was to investigate the effect of oral carbohydrate with amino acid [oral nutritional supplement (ONS)] solution on oxidative stress in healthy persons. Fourteen healthy volunteers were segregated into control and ONS groups. Volunteers in the ONS group ingested 250 ml of Arginaid Water (Nestle Japan, Tokyo, Japan) in the evening before the experiment and at 7:00 am on the day of the experiment. Volunteers in the control group fasted after dinner and drank only water until 7:00 am on the day of the experiment. In both groups, blood was collected at 9:00 am. The serum total oxidant levels and antioxidant capacity were assessed by d-ROMs (derivatives of reactive oxygen metabolites) test and BAP (biological antioxidant potential) test, respectively. In the ONS group, the serum d-ROMs level was significantly lower than in the control group (297 ± 43 and 327 ± 41 U.CARR, respectively, p = 0.018), while the serum BAP level was significantly higher than the control group (2410 ± 432 and 1979 ± 397 µmol/l, respectively, p = 0.005). The OXY level of Arginaid Water was much higher than preOp drink (Nutricia, Ireland). In conclusion, our study showed that an ONS with arginine loading could decrease oxidative stress and increase antioxidant capacity in healthy volunteers.
(キーワード): Amino Acids / Antioxidants / Carbohydrates / Cross-Over Studies / Fasting / Humans / Japan / Oxidative Stress / Reactive Oxygen Species
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s00540-017-2355-x
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28421317; ● CiNii @ 国立情報学研究所 (CRID): 1573106361639755008; ● Summary page in Scopus @ Elsevier: 2-s2.0-85017579285

(DOI: 10.1007/s00540-017-2355-x, PubMed: 28421317, CiNii: 1573106361639755008, Elsevier: Scopus) Yumiko Miyatake, Tetsuya Shiuchi, Kazuaki Mawatari, Satomi Toda, Yasuko Taniguchi, Akari Futami, Fukiko Sato, Masashi Kuroda, Mayu Sebe, Rie Tsutsumi, Nagakatsu Harada, Yasuhiko Minokoshi, Tadahiro Kitamura, Koro Gotoh, Masaki Ueno, Yutaka Nakaya and Hiroshi Sakaue :
Intracerebroventricular injection of ghrelin decreases wheel running activity in rats.,
Peptides, Vol.87, 12-19, 2017.

(要約): There is an increasing interest in elucidating the molecular mechanisms by which voluntary exercise is regulated. In this study, we examined how the central nervous system regulates exercise. We used SPORTS rats, which were established in our laboratory as a highly voluntary murine exercise model. SPORTS rats showed lower levels of serum ghrelin compared with those of the parental line of Wistar rats. Intracerebroventricular and intraperitoneal injection of ghrelin decreased wheel-running activity in SPORTS rats. In addition, daily injection of the ghrelin inhibitor JMV3002 into the lateral ventricles of Wistar rats increased wheel-running activity. Co-administration of obestatin inhibited ghrelin-induced increases in food intake but did not inhibit ghrelin-induced suppression of voluntary exercise in rats. Growth hormone secretagogue receptor (GHSR) in the hypothalamus and hippocampus of SPORTS rats was not difference that in control rats. We created an arcuate nucleus destruction model by administering monosodium glutamate (MSG) to neonatal SPORTS rats. Injection of ghrelin into MSG-treated rats decreased voluntary exercise but did not increase food intake, suggesting that wheel-running activity is not controlled by the arcuate nucleus neurons that regulate feeding. These results provide new insights into the mechanism by which ghrelin regulates voluntary activity independent of arcuate nucleus neurons.
(徳島大学機関リポジトリ): ● Metadata: 113364
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.peptides.2016.11.005
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27825986; ● Summary page in Scopus @ Elsevier: 2-s2.0-84995961350

(徳島大学機関リポジトリ: 113364, DOI: 10.1016/j.peptides.2016.11.005, PubMed: 27825986, Elsevier: Scopus) 堤理恵, 阪上浩, 西村匡司 :
ARDS患者に投与すべき熱量はどのように決めるのか?, --- ARDS-その常識は正しいか?- ---,
救急·集中治療, Vol.29, No.1-2, 125-1313, 2017年.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1572824886667961728

(CiNii: 1572824886667961728) Kadota Takako, Nami Kakuta, Horikawa T. Yousuke, Rie Tsutsumi, Takuro Oyama, Katsuya Tanaka and Yasuo Tsutsumi :
Plasma substance P concentrations in patients undergoing general anesthesia: an objective marker associated with postoperative nausea and vomiting,
JA Clinical Reports, Vol.2, No.9, 2016.

(徳島大学機関リポジトリ): ● Metadata: 114557
(出版サイトへのリンク): ● Publication site (DOI): 10.1186/s40981-016-0034-9
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1186/s40981-016-0034-9

(徳島大学機関リポジトリ: 114557, DOI: 10.1186/s40981-016-0034-9) Sebe Mayu, Rie Tsutsumi, Yamaguchi Sotaro, Horikawa T. Yousuke, Harada Nagakatsu, Takuro Oyama, Nami Kakuta, Katsuya Tanaka, Yasuo Tsutsumi, Yutaka Nakaya and Hiroshi Sakaue :
The synergistic effects of omega-3 fatty acids against 5-fluorouracil-induced mucosal impairment in mice.,
BMC Nutrition, Vol.2, No.17, 1-10, 2016.

(徳島大学機関リポジトリ): ● Metadata: 114371
(出版サイトへのリンク): ● Publication site (DOI): 10.1186/s40795-016-0057-7
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1186/s40795-016-0057-7

(徳島大学機関リポジトリ: 114371, DOI: 10.1186/s40795-016-0057-7) Rie Tsutsumi, Masakazu Goda, Chisa Fujimoto, Kyoko Kanno, Misaki Nobe, Yoshiaki Kitamura, Koji Abe, Misako Kawai, Hideki Matsumoto, Tohru Sakai and Noriaki Takeda :
Effects of chemotherapy on gene expression of lingual taste receptors in patients with head and neck cancer.,
The Laryngoscope, Vol.126, No.3, E103-E109, 2015.

(要約): We aimed to test the hypothesis that chemotherapy changes the gene expression of taste receptors in the tongue to induce dysgeusia in patients with head and neck cancer. Prospective observation study. We enrolled 21 patients who received chemoradiotherapy and five patients who underwent radiotherapy for head and neck cancer. The messenger RNA (mRNA) levels of the taste receptor subunits T1R1, T1R2, T1R3, and T2R5 were measured in lingual mucosa scrapings obtained with a small spatula. The perception thresholds of umami, sweet, and bitter tastes were assessed by the whole mouth gustatory test. In four patients with severe stomatitis induced by chemoradiotherapy, the mRNA levels of T1R1, T1R2, T1R3, and T2R5 in the lingual mucosa were significantly decreased. However, in 17 patients with mild/moderate stomatitis, the mRNA levels of T1R3 were significantly and transiently decreased, whereas those of T1R1 and T1R2 remained unchanged and those of T2R5 mRNA were significantly and transiently increased after chemotherapy. There was a significant negative correlation between the perception thresholds of umami or sweet tastes and lingual mRNA levels of T1R3 in patients with mild/moderate stomatitis after chemotherapy. Although the perception threshold of bitter taste remained unchanged, lingual mRNA levels of T2R5 were significantly increased in patients who complained of phantogeusia after chemotherapy. Chemotherapy specifically changed the gene expression of T1R3 and T2R5 in head and neck cancer patients with mild/moderate stomatitis, resulting in both dysgeusia of umami and sweet tastes as well as phantogeusia. 4. Laryngoscope, 126:E103-E109, 2016.
(キーワード): Adult / Aged / Aged, 80 and over / 分散分析 (analysis of variance) / Antineoplastic Agents / Chemoradiotherapy / Cohort Studies / Dysgeusia / Female / 遺伝子発現 (gene expression) / Head and Neck Neoplasms / Humans / 日本 (Japan) / Male / Middle Aged / Prognosis / Prospective Studies / RNA, Messenger / Receptors, G-Protein-Coupled / Risk Assessment / Severity of Illness Index / Taste Buds / Tongue
(出版サイトへのリンク): ● Publication site (DOI): 10.1002/lary.25679
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26422579; ● Search Scopus @ Elsevier (PMID): 26422579; ● Search Scopus @ Elsevier (DOI): 10.1002/lary.25679

(DOI: 10.1002/lary.25679, PubMed: 26422579) Tomohiro Soga, Katsuyoshi Kume, Nami Kakuta, Eisuke Hamaguchi, Rie Tsutsumi, Ryosuke Kawanishi, Kohei Fukuta, Katsuya Tanaka and Yasuo M. Tsutsumi :
Fosaprepitant versus ondansetron for the prevention of postoperative nausea and vomiting in patients who undergo gynecologic abdominal surgery with patient-controlled epidural analgesia: a prospective, randomized, double-blind study.,
Journal of Anesthesia, Vol.29, No.5, 696-701, 2015.

(要約): No (0 %) patient in the NKI group experienced vomiting after surgery; however, 4-6 (20-30 %) of 20 patients in the ONS group experienced vomiting. This difference was significant at 0-24, 0-48, and 0-72 h. During the study period, no significant differences existed between the NK1 and ONS groups in the incidence of PONV, complete response rate, rescue antiemetic use, nausea score, and VAS score for pain.
(徳島大学機関リポジトリ): ● Metadata: 109689
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s00540-015-2006-z
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25801542; ● Summary page in Scopus @ Elsevier: 2-s2.0-84945453279

(徳島大学機関リポジトリ: 109689, DOI: 10.1007/s00540-015-2006-z, PubMed: 25801542, Elsevier: Scopus) Tohru Sakai, Tomoyo Taki, Akiko Nakamoto, Shiho Tazaki, Mai Arakawa, Mariko Nakamoto, Rie Tsutsumi and Emi Shuto :
Dietary ribonucleic Acid suppresses inflammation of adipose tissue and improves glucose intolerance that is mediated by immune cells in C57BL/6 mice fed a high-fat diet.,
Journal of Nutritional Science and Vitaminology, Vol.61, No.1, 73-78, 2015.

(要約): Recent evidence suggests that immune cells play an important role in differentiation of inflammatory macrophages in adipose tissue, which contributes to systemic chronic inflammation. Dietary ribonucleic acid (RNA) has been shown to modulate immune function. We hypothesized that RNA affects immune cell function in adipose tissue and then improves inflammatory response in adipose tissue. C57/BL6 mice and recombination activating gene-1 (RAG-1) knockout mice on a C57BL/6 mice background were fed a high-fat diet containing 1% RNA for 12 wk. An oral glucose tolerance test was performed. Supplementation of dietary RNA in C57BL/6 mice fed a high-fat diet resulted in a smaller area under the curve (AUC) after oral glucose administration than that for control mice. The mRNA expression levels of inflammation-related cytokines in adipose tissue and serum interleukin-6 levels were reduced by dietary RNA supplementation. Interestingly, reduction of the AUC value by RNA supplementation was abolished in T and B cell-deficient RAG-1 knockout mice. These results indicate that RNA improves inflammation in adipose tissue and reduces the AUC value following oral glucose administration in a T and B cell-dependent manner.
(出版サイトへのリンク): ● Publication site (DOI): 10.3177/jnsv.61.73
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25994141; ● Summary page in Scopus @ Elsevier: 2-s2.0-84929733065

(DOI: 10.3177/jnsv.61.73, PubMed: 25994141, Elsevier: Scopus) Akiko Nakamoto, Emi Shuto, Rie Tsutsumi, Mariko Nakamoto, Yoshitaka Nii and Tohru Sakai :
Vitamin A Deficiency Impairs Induction of Oral Tolerance in Mice.,
Journal of Nutritional Science and Vitaminology, Vol.61, No.2, 147-153, 2015.

(要約): Oral tolerance is a phenomenon of induction of systemic unresponsiveness to antigens ingested by the oral route and loss of immune response. Studies have shown the importance of vitamin A in oral tolerance in vitro but not in an in vivo experimental model. Therefore, we carried out experiments to determine how vitamin A deficiency affects tolerance induction and the ability of mesenteric lymph node (MLN) CD11c(+) cells to induce regulatory T cells (Tregs). Immunological tolerance was induced by oral ovalbumin (OVA) administration in vitamin A-sufficient mice. OVA-specific antibody and cytokine production were significantly reduced. On the other hand, in vitamin A-deficient mice, both OVA-specific antibody and cytokine production were not suppressed by oral OVA administration. Regarding induction of Tregs, the conversion rate of Foxp3(+) cells from naïve CD4(+) cell by CD11c(+) cells was decreased in vitamin A-deficient mice. Our study indicates that vitamin A deficiency causes the breakdown of oral tolerance in vivo.
(出版サイトへのリンク): ● Publication site (DOI): 10.3177/jnsv.61.147
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26052145; ● Summary page in Scopus @ Elsevier: 2-s2.0-84930703907

(DOI: 10.3177/jnsv.61.147, PubMed: 26052145, Elsevier: Scopus) Thejaswini Venkatesh, S Padmanaban Suresh and Rie Tsutsumi :
New insights into the genetic basis of infertility.,
The Application of Clinical Genetics, Vol.7, 235-243, 2014.

(要約): Infertility is a disease of the reproductive system characterized by inability to achieve pregnancy after 12 or more months of regular unprotected sexual intercourse. A variety of factors, including ovulation defects, spermatogenic failure, parental age, obesity, and infections have been linked with infertility, in addition to specific karyotypes and genotypes. The study of genes associated with infertility in rodent models has expanded the field of translational genetics in identifying the underlying cause of human infertility problems. Many intriguing aspects of the molecular basis of infertility in humans remain poorly understood; however, application of genetic knowledge in this field looks promising. The growing literature on the genetics of human infertility disorders deserves attention and a critical concise summary is required. This paper provides information obtained from a systematic analysis of the literature related to current research into the genetics of infertility affecting both sexes.
(出版サイトへのリンク): ● Publication site (DOI): 10.2147/TACG.S40809
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25506236; ● Search Scopus @ Elsevier (PMID): 25506236; ● Search Scopus @ Elsevier (DOI): 10.2147/TACG.S40809

(DOI: 10.2147/TACG.S40809, PubMed: 25506236) Yasuo Tsutsumi, Rie Tsutsumi, Yousuke T. Horikawa, Yoko Sakai, Eisuke Hamaguchi, Hiroshi Kitahata, Asuka Kasai, Noriko Kambe and Katsuya Tanaka :
Geranylgeranylacetone and volatile anesthetic-induced cardiac protection synergism is dependent on caveolae and caveolin-3.,
Journal of Anesthesia, Vol.28, No.5, 733-739, 2014.

(要約): Pharmacological preconditioning, including that with geranylgeranylacetone (GGA) and volatile anesthetics, has been shown to confer cardiac protection from ischemia/reperfusion injury although the mechanisms for this protection are poorly understood. Caveolins, integral membrane proteins that act as scaffolding proteins in caveolar membranes, localize molecules involved in cardiac protection. We have tested the hypothesis that caveolin-3 (Cav-3), the predominant isoform in cardiac myocytes, is essential for the synergistic effect observed between GGA and volatile anesthetics. Mice were randomly assigned to receive GGA, isoflurane [0.5 and 1.0 minimum alveolar concentration (MAC)], or GGA + isoflurane (0.5 MAC). An in vivo mouse model of ischemia/reperfusion injury was tested in wild-type and Cav-3 knockout mice, and the infarct size was determined. Biochemical assays were also performed in excised hearts. Geranylgeranylacetone and therapeutic isoflurane (1.0 MAC) independently reduced infarct size (31.6 ± 6.1 and 28.0 ± 5.0 % of the area at risk, respectively; n = 10) as compared to the controls (45.8 ± 9.4 %; n = 10). The combination GGA + sub-therapeutic isoflurane (0.5 MAC) further decreased the infarct size to 19.3 ± 5.1 % (n = 10). Preconditioning [GGA, isoflurane (1.0 MAC), and GGA + isoflurane] increased the amount of Cav-3 protein in the discontinuous sucrose-gradient buoyant fractions. Additionally, cardiac protection was not observed in Cav-3 knockout mice following the administration of GGA, isoflurane, and GGA + isoflurane. Combined administration of GGA + isoflurane had a synergistic effect, enhancing the protection against myocardial infarction to a greater extent than either drug alone. This beneficial effect is mediated by Cav-3 expression.
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s00540-014-1816-8
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24633659; ● Search Scopus @ Elsevier (PMID): 24633659; ● Search Scopus @ Elsevier (DOI): 10.1007/s00540-014-1816-8

(DOI: 10.1007/s00540-014-1816-8, PubMed: 24633659) Yasuo Tsutsumi, Rie Tsutsumi, Eisuke Hamaguchi, Yoko Sakai, Asuka Kasai, Yoshihiro Ishikawa, Utako Yokoyama and Katsuya Tanaka :
Exendin-4 ameliorates cardiac ischemia/reperfusion injury via caveolae and caveolins-3.,
Cardiovascular Diabetology, Vol.13, 132, 2014.

(要約): Exendin-4 protected cardiac myocytes (CM) from SI/R [35.6 ± 12.6% vs. 64.4 ± 18.0% cell death, P = 0.034] and apoptosis but this protection was abolished by MβCD (71.8 ± 10.8% cell death, P = 0.004). Furthermore, Cav-3/GLP-1R co-localization was observed and membrane fractionation by sucrose density gradient centrifugation of CM treated with MβCD + exendin-4 revealed that buoyant (caveolae enriched) fractions decreased Cav-3 compared to CM treated with exendin-4 exclusively. Furthermore, exendin-4 induced a reduction in infarct size and cardiac troponin relative to control (infarct size: 25.1 ± 8.2% vs. 41.4 ± 4.1%, P < 0.001; troponin: 36.9 ± 14.2 vs. 101.1 ± 22.3 ng/ml, P < 0.001). However, exendin-4 induced cardiac protection was abolished in Cav-3 KO mice (infarct size: 43.0 ± 6.4%, P < 0.001; troponin: 96.8 ± 26.6 ng/ml, P = 0.001).
(キーワード): Animals / Caveolae / Caveolin 3 / Hypoglycemic Agents / 虚血 (ischemia) / Male / Mice, Inbred C57BL / ノックアウトマウス (knockout mice) / Myocardial Reperfusion Injury / 心筋 (myocardium) / Myocytes, Cardiac / Peptides / Rats, Wistar / Venoms
(出版サイトへのリンク): ● Publication site (DOI): 10.1186/s12933-014-0132-9
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25194961; ● Summary page in Scopus @ Elsevier: 2-s2.0-84964812082

(DOI: 10.1186/s12933-014-0132-9, PubMed: 25194961, Elsevier: Scopus) Rie Tsutsumi, Tomomi Yoshida, Yoshitaka Nii, Naoki Okahisa, Shinya Iwata, Masao Tsukayama, Rei Hashimoto, Yasuko Taniguchi, Hiroshi Sakaue, Toshio Hosaka, Emi Shuto and Tohru Sakai :
Sudachitin, a polymethoxylated flavone, improves glucose and lipid metabolism by increasing mitochondrial biogenesis in skeletal muscle.,
Nutrition & Metabolism, Vol.11, 32, 2014.

(要約): Obesity is a major risk factor for insulin resistance, type 2 diabetes, and stroke. Flavonoids are effective antioxidants that protect against these chronic diseases. In this study, we evaluated the effects of sudachitin, a polymethoxylated flavonoid found in the skin of the Citrus sudachi fruit, on glucose, lipid, and energy metabolism in mice with high-fat diet-induced obesity and db/db diabetic mice. In our current study, we show that sudachitin improves metabolism and stimulates mitochondrial biogenesis, thereby increasing energy expenditure and reducing weight gain. C57BL/6 J mice fed a high-fat diet (40% fat) and db/db mice fed a normal diet were treated orally with 5 mg/kg sudachitin or vehicle for 12 weeks. Following treatment, oxygen expenditure was assessed using indirect calorimetry, while glucose tolerance, insulin sensitivity, and indices of dyslipidemia were assessed by serum biochemistry. Quantitative polymerase chain reaction was used to determine the effect of sudachitin on the transcription of key metabolism-regulating genes in the skeletal muscle, liver, and white and brown adipose tissues. Primary myocytes were also prepared to examine the signaling mechanisms targeted by sudachitin in vitro. Sudachitin improved dyslipidemia, as evidenced by reduction in triglyceride and free fatty acid levels, and improved glucose tolerance and insulin resistance. It also enhanced energy expenditure and fatty acid β-oxidation by increasing mitochondrial biogenesis and function. The in vitro assay results suggest that sudachitin increased Sirt1 and PGC-1α expression in the skeletal muscle. Sudachitin may improve dyslipidemia and metabolic syndrome by improving energy metabolism. Furthermore, it also induces mitochondrial biogenesis to protect against metabolic disorders.
(出版サイトへのリンク): ● Publication site (DOI): 10.1186/1743-7075-11-32
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25114710; ● Search Scopus @ Elsevier (PMID): 25114710; ● Search Scopus @ Elsevier (DOI): 10.1186/1743-7075-11-32

(DOI: 10.1186/1743-7075-11-32, PubMed: 25114710) 堤保夫, 堤理恵, 久米克佳, 角田奈美, 山崎理恵, 田中克哉 :
主観的包括的評価(SGA)の結果よりみる周術期栄養状態の実態,
臨床麻酔, Vol.38, No.5, 745-750, 2014年. Rie Tsutsumi and Yasuo Tsutsumi :
Peptides and proteins in whey and their benefits for human health.,
Austin Journal of Nutrition and Food Sciences, Vol.1, No.1, 1-9, 2014. 堤理恵, 平田容子, 中瀧恵実子, 大藤純, 堤保夫, 中屋豊, 今中秀光, 西村匡司 :
ICU患者のエネルギー消費量と病勢との関連の検討．,
日本集中治療医学会雑誌, Vol.21, 173-174, 2014年.

(キーワード): energy expenditure / respiratory quotient (RQ) / mechanical ventilation
(出版サイトへのリンク): ● Publication site (DOI): 10.3918/jsicm.21.173
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390001204445489664; ● Search Scopus @ Elsevier (DOI): 10.3918/jsicm.21.173

(DOI: 10.3918/jsicm.21.173, CiNii: 1390001204445489664) Toshio Hosaka, Sayaka Sasaga, Yukiko Yamasaka, Yoshitaka Nii, Kazuhiro Edazawa, Rie Tsutsumi, Emi Shuto, Naoki Okahisa, Shinya Iwata, Hiroyuki Tomotake and Tohru Sakai :
Treatment with buckwheat bran extract prevents the elevation of serum triglyceride levels and fatty liver in KK-A(y) mice.,
The Journal of Medical Investigation : JMI, Vol.61, No.3-4, 345-352, 2014.

(要約): Buckwheat powder or protein has been shown to decrease the total serum cholesterol level in non-diabetic mice or rats. However, the lipid-lowering effect of buckwheat bran extract (BBE) in diabetic mice has not been fully elucidated. KK-A(y) mice that received six-week treatment with BBE showed decreased body weight and liver weight compared to those of control (vehicle) mice. However, there was no significant difference in food intake. BBE treatments prevented liver triglyceride accumulation and decreased the serum level of triglycerides. In addition, mRNA expression levels lipogenic enzyme genes, fatty acid synthase, acetyl-coenzyme a oxidase and stearyl-coenzyme a desaturase 1, but not those of -oxidized enzyme genes, were decreased in BBE-treated mice. Level of transcription factors ChREBP and SREBP1c, transcripts of lipogenic genes, were also decreased in BBE-treated mice. These results suggest that chronic treatment with BBE derivatives could have beneficial effects on hypertriglycemia in patients with type 2 diabetes mellitus.
(徳島大学機関リポジトリ): ● Metadata: 109583
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.61.345
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25264053; ● Summary page in Scopus @ Elsevier: 2-s2.0-84907513565

(徳島大学機関リポジトリ: 109583, DOI: 10.2152/jmi.61.345, PubMed: 25264053, Elsevier: Scopus) 堤理恵, 堤保夫 :
ICUにおける消化態栄養剤の効果と使い方の検討,
臨床栄養, Vol.123, 600-605, 2013年. 堤保夫, 武川茉莉子, 濵口英佑, 田中克哉, 久米克佳, 中屋豊, 堤理恵 :
重症患者の栄養療法に起因する代謝性有害反応―エネルギーの過剰投与による筋タンパク異化と栄養ストレス―,
静脈経腸栄養, Vol.28, No.6, 1251-1257, 2013年.

(要約): 【目的】本研究では，エネルギーの過剰投与が筋タンパク異化および栄養ストレスに与える影響について検討した．【対象及び方法】対象は，当院ICUに入室した患者のうち呼吸管理を必要とする患者30名とした．エネルギー消費量を測定し，投与エネルギー量と比較して投与不足となっている群 (U群)，両者がほぼ一致している適正群 (A群)，過剰投与となっている群 (O群) の3群に分け比較検討した．【結果】尿中クレアチニン量による補正尿中3-メチルヒスチジン値及び尿中ノルアドレナリン値はU・A群に有意差はなかったが，O群では有意に増加していた．さらに，尿中3-メチルヒスチジン値と尿中ノルアドレナリン値の間に相関関係が認められた．【結論】エネルギーの過剰投与により筋タンパクの異化が亢進するとともに，ノルアドレナリンの分泌に伴う栄養ストレスが筋タンパク分解を促進させることが明らかとなった．
(キーワード): 過剰エネルギー / 筋タンパク異化 / 栄養ストレス
(出版サイトへのリンク): ● Publication site (DOI): 10.11244/jjspen.28.1251
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390001204427337472; ● Search Scopus @ Elsevier (DOI): 10.11244/jjspen.28.1251

(DOI: 10.11244/jjspen.28.1251, CiNii: 1390001204427337472) Tohru Sakai, Tomoyo Taki, Akiko Nakamoto, Emi Shuto, Rie Tsutsumi, Takayuki Toshimitsu, Seiya Makino and Shuuji Ikegami :
Lactobacillus plantarum OLL2712 regulates glucose metabolism in C57BL/6 mice fed a high-fat diet.,
Journal of Nutritional Science and Vitaminology, Vol.59, No.2, 144-147, 2013.

(要約): The aim of the present study was to determine the effect of oral administration of Lactobacillus plantarum OLL2712 (L. plantarum OLL2712) on glucose and lipid metabolism in mice with high-fat diet-induced obesity. Mice that had been administered 10(9) cfu heat-killed L. plantarum OLL2712 for 12 wk showed significant reduction of blood glucose levels in response to insulin. Furthermore, mRNA expression of interleukin-1β in adipose tissue and serum levels of nonesterified fatty acids in mice administered L. plantarum OLL2712 were significantly lower than those in control mice. These results indicate that L. plantarum OLL2712 regulates glucose metabolism.
(キーワード): Adipose Tissue / Animals / Blood Glucose / コレステロール (cholesterol) / Diet, High-Fat / Fatty Acids, Nonesterified / インスリン (insulin) / Interleukin-1beta / Lactobacillus plantarum / Lipid Metabolism / Male / Mice / Mice, Inbred C57BL / 肥満症 (obesity) / Probiotics / RNA, Messenger / Triglycerides
(出版サイトへのリンク): ● Publication site (DOI): 10.3177/jnsv.59.144
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23727645; ● CiNii @ 国立情報学研究所 (CRID): 1390282681301114368; ● Summary page in Scopus @ Elsevier: 2-s2.0-84878434562

(DOI: 10.3177/jnsv.59.144, PubMed: 23727645, CiNii: 1390282681301114368, Elsevier: Scopus) 堤理恵, 武川茉莉子, 田中克哉, 堤保夫 :
整形外科病棟における術前経口補水液の導入とその効果,
栄養-評価と治療, Vol.30, 71-76, 2013年. 堤理恵, 武川茉莉子, 山口想太郎, 堤保夫 :
早期集中治療におけるPEPTAMEN AFの有効性の検討,
臨床栄養, Vol.121, 113-117, 2012年. Rie Tsutsumi, Yasuo M. Tsutsumi, Yousuke T. Horikawa, Yozo Takehisa, Toshio Hosaka, Nagakatsu Harada, Tohru Sakai and Yutaka Nakaya :
Decline in anthropometric evaluation predicts a poor prognosis in geriatric patients.,
Asia Pacific Journal of Clinical Nutrition, Vol.21, No.1, 44-51, 2012.

(要約): Malnutrition is frequent in the geriatric population and is often undetected and untreated. Although we often use serum albumin as a nutritional marker, it has limitations in elderly patients in terms of predicting diseases and infections. Anthropometric measurements are not commonly used, despite their simple, easy, and effective characteristics. We evaluated the associations between anthropometric measurements with other nutritional factors and examined its relationship with mortality, decubitus ulcer, length of hospital stay and antibiotic usage. We enrolled 223 patients, performed anthropometric measurements and then followed them for a mean of 24 months. Patients with hypoalbuminemia but with normal body measurements tended to increase serum albumin levels over the next 24 months and had more favorable outcomes including being discharged. Patients with normal albumin but decreased body measurements resulted in a progressive drop in serum albumin and had a higher mortality rate. Additionally, patients with hypoalbuminemia had higher antibiotic usage than patients without hypoalbuminemia. Decreases in anthropometric measurements were related to mortality, length of hospital stay, and decubitus ulcer. Anthropometric measurements are easily obtained and closely associated with mortality, decubitus ulcer, and length of hospital stay. Anthropometric measurements used in conjunction with serum albumin are more predictive of patient outcome then serum albumin alone.
(キーワード): Aged / Aged, 80 and over / 分散分析 (analysis of variance) / Anthropometry / Anti-Bacterial Agents / Biological Markers / Female / Follow-Up Studies / Geriatric Assessment / Humans / Hypoalbuminemia / 日本 (Japan) / Length of Stay / Male / Malnutrition / Nutrition Assessment / Nutrition Surveys / Nutritional Status / Predictive Value of Tests / Pressure Ulcer / Prevalence / Prognosis / Prospective Studies / Risk Factors / Serum Albumin / Severity of Illness Index / Survival Analysis
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22374559; ● Search Scopus @ Elsevier (PMID): 22374559

(PubMed: 22374559) Kayo Hirose, Yasuo M. Tsutsumi, Rie Tsutsumi, Masayuki Shono, Erika Katayama, Michiko Kinoshita, Katsuya Tanaka and Shuzo Oshita :
Role of the O-linked -N-acetylglucosamine in the cardioprotection induced by isoflurane.,
Anesthesiology, Vol.115, No.5, 955-962, 2011.

(要約): Cardiac protection by volatile anesthetic-induced preconditioning and ischemic preconditioning have similar signaling pathways. Recently, it was reported that augmentation of protein modified with O-linked -N-acetylglucosamine (O-GlcNAc) contributes to cardiac protection. This study investigated the role of O-GlcNAc in cardiac protection induced by anesthetic-induced preconditioning. O-GlcNAc-modified proteins were visualized by immunoblotting. Tolerance against ischemia or reperfusion was tested in vivo (n = 8) and in vitro (n = 6). The opening of the mitochondrial permeability transition pore (mPTP) upon oxidative stress was examined in myocytes treated with calcein AM (n = 5). Coimmunoprecipitation and enzymatic labeling were performed to detect the mitochondrial protein responsible for the mPTP opening. Isoflurane treatment and the consequent augmentation of O-GlcNAc concentrations reduced the infarct size (26 ± 5% [mean ± SD], P < 0.001) compared with the control. The protective effect of O-GlcNAc was eliminated in the group pretreated with the O-GlcNAc transferase inhibitor alloxan (39 ± 5%, P < 0.001). Myocyte survival also showed the same result in vitro. Formation of the mPTP was abrogated in the isoflurane-treated cells (86 ± 4%, P < 0.001) compared with the control and alloxan-plus-isoflurane-treated cells (57 ± 7%, P < 0.001). Coimmunoprecipitation and enzymatic labeling studies revealed that the O-GlcNAc-modified, voltage-dependent anion channel restained the mPTP opening. Isoflurane induced O-GlcNAc modification of mitochondrial voltage-dependent anion channel. This modification inhibited the opening of the mPTP and conferred resistance to ischemia-reperfusion stress.
(キーワード): Acetylglucosamine / Anesthetics, Inhalation / Animals / Cell Survival / Heart / Ischemic Preconditioning, Myocardial / Isoflurane / Male / Mice / Mice, Inbred C57BL / Mitochondrial Membrane Transport Proteins / Myocardial Reperfusion Injury / Voltage-Dependent Anion Channels
(出版サイトへのリンク): ● Publication site (DOI): 10.1097/ALN.0b013e31822fcede
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21876430; ● Search Scopus @ Elsevier (PMID): 21876430; ● Search Scopus @ Elsevier (DOI): 10.1097/ALN.0b013e31822fcede

(DOI: 10.1097/ALN.0b013e31822fcede, PubMed: 21876430) Yasuo M. Tsutsumi, Rie Tsutsumi, Kazuaki Mawatari, Yutaka Nakaya, Michiko Kinoshita, Katsuya Tanaka and Shuzo Oshita :
Compound K, a metabolite of ginsenosides, induces cardiac protection mediated nitric oxide via Akt/PI3K pathway.,
Life Sciences, Vol.88, No.15-16, 725-729, 2011.

(要約): Compound K (C-K; 20-O-D-glucopyranosyl-20(S)-protopanaxadiol) is a novel ginsenoside metabolite formed by intestinal bacteria and does not occur naturally in ginseng. In this study, we investigated whether administration of C-K has protective effects on myocardial ischemia-reperfusion injury and its potential mechanisms.
(キーワード): Androstadienes / Animals / カルシウム (calcium) / Ginsenosides / Immunoblotting / 男性 (male) / Mice / Mice, Inbred C57BL / Mitochondria, Heart / Myocardial Infarction / Myocardial Reperfusion Injury / 一酸化窒素 (nitric oxide) / Nitric Oxide Synthase Type III / Phosphatidylinositol 3-Kinases / Proto-Oncogene Proteins c-akt
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.lfs.2011.02.011
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21338613; ● Summary page in Scopus @ Elsevier: 2-s2.0-79953283184

(DOI: 10.1016/j.lfs.2011.02.011, PubMed: 21338613, Elsevier: Scopus) Toshio Hosaka, Yoshitaka Nii, Hiroyuki Tomotake, Takahiro Ito, Aya Tamanaha, Yukiko Yamasaka, Sayaka Sasaga, Kazuhiro Edazawa, Rie Tsutsumi, Emi Shuto, Naoki Okahisa, Shinya Iwata and Tohru Sakai :
Extracts of common buckwheat bran prevent sucrose digestion.,
Journal of Nutritional Science and Vitaminology, Vol.57, No.6, 441-445, 2011.

(要約): Buckwheat has been shown to have various health benefits such as reduction of hypertension and improvement of hypercholesterolemia; however, its effect on diabetes has not been fully elucidated. In this study, buckwheat bran extracts (BBE) inhibited sucrase activity in vitro more effectively than buckwheat. Balb/c mice pretreated with BBE showed dose-dependent reductions of blood glucose, greater than those observed with control mice, within 60 min following oral sucrose administration. Blood glucose levels in mice pretreated with buckwheat extracts were also significantly lower compared to those in control mice within 30 min following oral administration of sucrose. However, rutin, one of the abundant polyphenols of BBE, did not lower blood glucose level. Our data indicate that components of BBE other than rutin have inhibitory activity against sucrase in vivo. These results suggest that BBE could have beneficial effects on diabetes.
(キーワード): Administration, Oral / Animals / Blood Glucose / 糖尿病 (diabetes mellitus) / Dietary Sucrose / 消化 (digestion) / Dose-Response Relationship, Drug / Fagopyrum / Male / Mice / Mice, Inbred BALB C / Phytotherapy / Plant Extracts / Rutin / Seeds / Sucrose
(出版サイトへのリンク): ● Publication site (DOI): 10.3177/jnsv.57.441
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22472288; ● Search Scopus @ Elsevier (PMID): 22472288; ● Search Scopus @ Elsevier (DOI): 10.3177/jnsv.57.441

(DOI: 10.3177/jnsv.57.441, PubMed: 22472288) Rie Tsutsumi, Devendra Mistry and Nicholas J. G. Webster :
Signaling responses to pulsatile gonadotropin-releasing hormone in LbetaT2 gonadotrope cells.,
The Journal of Biological Chemistry, Vol.285, No.26, 20262-20272, 2010.

(要約): The hypothalamic neuropeptide gonadotropin-releasing hormone (GnRH) is secreted in a pulsatile fashion by hypothalamic neurons, and alterations in pulse frequency and amplitude differentially regulate gonadotropin synthesis and release. In this study, we investigated the kinetics of G(s) and G(q) signaling in response to continuous or pulsatile GnRH using fluorescence resonance energy transfer reporters in live mouse LbetaT2 gonadotrope cells. cAMP and protein kinase A-dependent reporters showed a rapid but transient increase in fluorescence resonance energy transfer signal with increasing doses of constant GnRH, and in contrast diacylglycerol (DAG) and calcium reporters showed a rapid and sustained signal. Multiple pulses of GnRH caused multiple pulses of cAMP and protein kinase A activation without desensitization, but the DAG and calcium reporters were rapidly desensitized resulting in inhibition of calcium and DAG responses. At the transcriptional level, both a cAMP-dependent cAMP-response element reporter and a DAG/calcium-dependent AP-1 reporter showed a pulse frequency-dependent increase in luciferase activity. However, constant GnRH stimulation gave very little cAMP-response element activation but very strong AP-1 activation. Based on these data, we propose that both the GnRH-R-G(s) and G(q) pathways are responsive to pulses of GnRH, but only the G(q) pathway is responsive to constant GnRH. Furthermore, the G(q) pathway is subject to desensitization with multiple GnRH pulses, but the G(s) pathway is not.
(キーワード): Animals / Calcium / Cell Line / Cyclic AMP / Cyclic AMP Response Element-Binding Protein / Cyclic AMP-Dependent Protein Kinases / Diglycerides / Fluorescence Resonance Energy Transfer / Gonadotrophs / Gonadotropin-Releasing Hormone / Immunoblotting / Intracellular Space / Kinetics / Luciferases / Mice / Models, Biological / リン酸化 (phosphorylation) / 情報伝達 (signal transduction) / Transcription Factor AP-1 / Transcriptional Activation
(出版サイトへのリンク): ● Publication site (DOI): 10.1074/jbc.M110.132662
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20406815; ● Search Scopus @ Elsevier (PMID): 20406815; ● Search Scopus @ Elsevier (DOI): 10.1074/jbc.M110.132662

(DOI: 10.1074/jbc.M110.132662, PubMed: 20406815)

MISC

徳里望, 阪上浩, 堤理恵, 黒田雅士, 升本早枝子, 黒井俊哉, 植木歩夢, 堤理恵, 阪上浩, 小瀧歩, 工藤千秋 :
認知症超早期発見チェックシート(Q-ESD)と老研式活動能力指標(TMIG-IC)との相関性の検討,
日本早期認知症学会誌, Vol.13, No.1, 42-48, 2020年.

(要約): 目的:急速な高齢化において認知症の早期発見・早期予防が重要であるが，プレクリニカル期における簡易的に検出可能なスクリーニング方法は開発されていない．今回，我々は，認知機能低下と関係の深い日常生活の変化を捉えるべく，認知症の超早期段階における発見チェックシート;The Questionnaires for Earlier Stage of Dementia(Q-ESD)を開発した．認知症と診断されていない高齢者を対象としてQ-ESDを実施し，その有用性に関して老研式活動能力指標との関連性を比較・検討した．対象と方法:全国13施設において，認知症簡易スクリーニング法TOP-Qスコアが1点以下の認知機能低下を認めない高齢者に対し，導入時と4ヵ月後にQ-ESDと老研式活動能力指標の調査をした．結果:対象者134名(男/女=25/109)の平均年齢は75.2±12.0歳，平均Q-ESDスコアは25.0±7.0点であった．Q-ESDと老研式活動能力指標の合計スコアに負の相関(P<0.05)がみられた．Q-ESDの改善・維持群，悪化群では初回調査時の手段的，知的，社会的ADLが有意に低値であった(p<0.05)．結論:Q-ESDは生活機能の低下を早期に検出し，Q-ESDのスコアの高値は将来の認知症発症の予備軍となり得る可能性が示唆された．(著者抄録)
(キーワード): *Catechin *肥満(実験的) *Biflavonoids *Proanthocyanidins *認知機能低下(実験的) 消化管微生物叢 *Procyanidin マウス動物 / *認知症(診断) 早期診断チェックリスト Mini-Mental State 老研式活動能力指標ヒト中年(45~64) 高齢者(65~79) 高齢者(80~) 男女
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1523669556040598272

(CiNii: 1523669556040598272)

総説・解説

庄野仁志, 堤理恵, 藤本知佐, 合田正和, 金村亮, 大西皓貴, 佐藤豪, 北村嘉章, 阿部晃治, 田村公一, 阪上浩, 武田憲昭 :
頭頸部癌に対する化学療法による味覚障害の分子メカニズムと食事介入による予防 (武田憲昭教授退任記念総説集),
耳鼻咽喉科臨床補冊, No.158, 138-141, 2022年2月.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1571980233936140416

(CiNii: 1571980233936140416) 高岡司, 遠藤亜紀, 松田和徳, 上田千鶴, 猿倉薫子, 堤理恵, 阪上浩, 酒井徹, 山本茂, 武田憲昭 :
新しい亜鉛栄養状態の評価法の開発と亜鉛欠乏性味覚障害の解明 (武田憲昭教授退任記念総説集),
耳鼻咽喉科臨床補冊, No.158, 133-137, 2022年2月.

(出版サイトへのリンク): ● Publication site (DOI): 10.5631/jibirinsuppl.158.133
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1570572859052590848; ● Search Scopus @ Elsevier (DOI): 10.5631/jibirinsuppl.158.133

(DOI: 10.5631/jibirinsuppl.158.133, CiNii: 1570572859052590848) 黒田雅士, 堤理恵, 阪上浩 :
【脂肪細胞・アディポサイトカインと糖尿病】脂肪細胞と糖尿病褐色脂肪細胞と糖尿病,
月刊糖尿病, Vol.14, No.1, 28-34, 2022年1月. 黒田雅士, 堤理恵, 阪上浩 :
脂肪細胞分化に対するエピジェネティック制御機構,
実験医学増刊, Vol.39, No.5, 32-38, 2021年3月. 黒田雅士, 堤理恵, 阪上浩 :
【個人差の理解へ向かう肥満症研究 GWAS，エピゲノム，腸内細菌，栄養学的知見から多様な病態を解明し，Precision Medicineをめざす】(第1章)代謝(エネルギー消費)の分子・細胞・個体メカニズム脂肪細胞分化に対するエピジェネティック制御機構,
実験医学, Vol.39, No.5, 654-660, 2021年3月.

(要約): 生体はヒストン修飾やDNAメチル化などのエピジェネティクスによる制御機構により染色体の局所構造を変化させて，ゲノムDNA中の膨大な情報の中から必要な遺伝子を選択して活性化・不活性化している．このエピジェネティクスによる遺伝子発現制御は幹・前駆細胞がある特定の機能をもった細胞へ分化する際にも重要な意義をもち，分化誘導中の時系列遺伝子発現プロファイルの形成に貢献している．脂肪細胞では分化のマスターレギュレーターPPARγを中心に，その誘導や標的遺伝子の活性化にかかわるエピゲノムの変化が解明されている．(著者抄録)
(キーワード): Histones Histone-Lysine N-Methyltransferase 遺伝子発現調節クロマチン DNAメチル化 CCAAT-Enhancer-Binding Protein-Beta 非翻訳RNA *エピジェネティックプロセス褐色脂肪細胞 Jumonji Domain-Containing Histone Demethylases *脂肪細胞分化ベージュ脂肪細胞細胞発生 Jmjd3 Protein KDM3A Protein EHMT1 Protein ヒト

原加奈子, 堤理恵, 中西信人, 三島優奈, 待田京香, 黒田雅士, 大藤純, 阪上浩 :
重症患者における筋萎縮と尿中タイチン濃度測定の意義,
四国医学雑誌, Vol.76, No.5-6, 267-272, 2020年12月.

(要約): タイチンは，骨格筋において最初に分解される蛋白質として注目されている．尿中のタイチンN末端断片濃度を測定できるELISAが開発され，筋ジストロフィー患者では健常人の数百倍のタイチンN末端断片が検出されることが報告されている．これまでに行った，重症病態における筋萎縮，筋機能低下のバイオマーカーとしての尿中タイチン濃度測定の有用性についての研究を中心に概説した．
(キーワード): バイオマーカー(尿) ICU *筋萎縮症(診断,X線診断) 筋節 X線CT 病勢悪化 *Connectin(尿) ヒト
(徳島大学機関リポジトリ): ● Metadata: 115785
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1050287363395004928

(徳島大学機関リポジトリ: 115785, CiNii: 1050287363395004928) 徳里望, 阪上浩, 堤理恵, 黒田雅士, 升本早枝子, 黒田雅士, 阪上浩 :
【糖・エネルギー代謝ネットワークupdate】脂肪細胞熱産生機構における転写因子による制御,
糖尿病·内分泌代謝科, Vol.51, No.1, 23-27, 2020年7月.

(キーワード): *Catechin *肥満(実験的) *Biflavonoids *Proanthocyanidins *認知機能低下(実験的) 消化管微生物叢 *Procyanidin マウス動物 / DNA-Binding Proteins *転写因子肥満トランスアクチベーター *熱産生 Interferon Regulatory Factors RNA-Binding Protein EWS エピジェネティックプロセス *褐色脂肪細胞脂肪細胞分化 Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-Alpha PRDM16 Protein Interferon Regulatory Factor-4 EBF1 Protein ヒト
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1521699229687059584

(CiNii: 1521699229687059584) 徳里望, 阪上浩, 堤理恵, 黒田雅士, 升本早枝子, 三島優奈, 堤理恵, 阪上浩 :
代謝動態の連関による生体機能制御骨格筋と代謝調節に注目して,
糖尿病·内分泌代謝科, Vol.51, No.1, 71-77, 2020年7月.

(キーワード): *Catechin *肥満(実験的) *Biflavonoids *Proanthocyanidins *認知機能低下(実験的) 消化管微生物叢 *Procyanidin マウス動物 / *エネルギー代謝肝臓飢餓筋萎縮症脂肪組織身体運動絶食 *ホメオスタシス *骨格筋廃用症候群ヒト
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1570854561610309760

(CiNii: 1570854561610309760) 堤理恵, Yasuo M. Tsutsumi , 阪上浩 :

救急・集中治療重症患者の栄養治療, Vol.27, No.7.8, 585-590, 2015年8月. Tohru Sakai, Emi Shuto and Rie Tsutsumi :
Soy-Derived Compounds and Immune Response,
Soy: Nutrition, consumption and Health, 147-159, 2013.

(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-84892079014

(Elsevier: Scopus) Rie Tsutsumi and G Nicholas J Webster :
GnRH pulsatility, the pituitary response and reproductive dysfunction.,
Endocrine Journal, Vol.56, No.6, 729-737, Jul. 2009.

(要約): GnRH plays an essential role in neuroendocrine control of reproductive function. In mammals, the pattern of gonadotropin secretion includes both pulse and surge phases, which are regulated independently. The pulsatile release of GnRH and LH plays an important role in the development of sexual function and in the normal regulation of the menstrual cycle. The importance of GnRH pulsatility was established in a series of classic studies. Fertility is impaired when GnRH pulsatility is inhibited by chronic malnutrition, excessive caloric expenditure, or aging. A number of reproductive disorders in women with including hypogonadotropic hypogonadism, hypothlamic amenorrhea, hyperprolactinemia and polycystic ovary syndrome (PCOS) are also associated with disruption of the normal pulsatile GnRH secretion. Despite these findings, the molecular mechanisms of this pulsatile GnRH regulation are not well understood. Here, we review recent studies about GnRH pulsatility, signaling and transcriptional response, and its implications for disease.
(キーワード): Animals / Female / Gonadotropin-Releasing Hormone / Humans / Infertility / Male / 下垂体 (pituitary gland) / Reproduction
(出版サイトへのリンク): ● Publication site (DOI): 10.1507/endocrj.K09E-185
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19609045; ● Search Scopus @ Elsevier (PMID): 19609045; ● Search Scopus @ Elsevier (DOI): 10.1507/endocrj.K09E-185

(DOI: 10.1507/endocrj.K09E-185, PubMed: 19609045)

講演・発表

Rie Tsutsumi :
The power of whey ; the benefit of whey based enteral nutrition in ICU patients,
Masashi Kuroda, Naho Ugawa, Etsuko Ishikawa, Yasuyo Kawabata, Saya Okamoto, Waka Sasaki, Saeko Masumoto, Rie Tsutsumi and Hiroshi Sakaue :
Transcription factor IRF7 and energy metabolism,
The 11th Scientific Meeting of the Asian Association for the Study of Diabetes., May 2019. Rie Tsutsumi, Yasuo Tsutsumi, Roth David, Patel Hemal, Tanaka Katsuya and Sakaue Hiroshi :
Leucine induces cardioprotection by promoting mitochondrial fusion and function via mTOR and Opa-1 signaling in vitro and diet induced obese mice.,
Keystone Symposia Conference, Kyoto, Oct. 2015. Rie Tsutsumi :
Obesity and lowered muscle mass in patients with rheumatoid arthritis,
Nagoya, Oct. 2015. Rie Tsutsumi :
Identifications of chemotherapy-sensitive taste receptors regulatiing dysgeusia in patients with head and nick cancer,
Asian Congress of Dietitian, Aug. 2014. Eisuke Hamaguchi, Shuzo Oshita, Katsuya Tanaka, Rie Tsutsumi and Yasuo M. Tsutsumi :
Glucagon-like peptide-1 induced cardiac protection is dependent on caveolin-3 expression.,
Experimental Biology Annual Meeting, Boston, Illinois, Apr. 2013. Rie Tsutsumi, Sasaga Sayaka and Yasuo Tsutsumi :
Whey protein promppts TCA cycle and increases energy expenditure via mTOR signaling.,
the 34th European Society for Clinical nutrition and Metabolism Congress, Barcelona, Spain, Sep. 2012. Rie Tsutsumi, Takegawa Mariko and Yasuo Tsutsumi :
Overfeeding induces nutritional stress and protein catabolism,
the 34th European Society for Clinical nutrition and Metabolism Congress, Barcelona, Spain, Sep. 2012. Rie Tsutsumi, Sasaga Sayaka, Takegawa Mariko and Yasuo Tsutsumi :
Whey based formula reduces intestinal atrophy and enhances antioxidant defenses against sepsis.,
Experimental Biology Annual Meeting, San Diego, California, Apr. 2012. Yasuo Tsutsumi, Hirose Kayo, Katayama Erika, Rie Tsutsumi, Kinoshita Michiko, Katsuya Tanaka and Shuzo Oshita :
Role of O-linked -N-acetylglucosamine in isoflurane induced cardiac protection.,
Experimental Biology Annual Meeting, Anaheim, California, Apr. 2010. Rie Tsutsumi, Kazuaki Mawatari, Katayama Erika, Yutaka Nakaya and Yasuo Tsutsumi :
Compound K produces cardiac protection by activating Akt phosphorylation.,
Experimental Biology Annual Meeting, Anaheim, California, Apr. 2010. E Katayama, Rie Tsutsumi, Yutaka Nakaya, K Hirose, K Tanaka, S Oshita and Yasuo Tsutsumi :
Role of mTOR/p70S6K in amino acid-induced caediac protection.,
Experimental Biology 2010(American Siciety for Nutrition), Anaheim,CA, Apr. 2010. 堤理恵 :
重度侵襲下における過剰栄養はタンパク異化をもたらす,
堤理恵 :
ICUにおける管理栄養士の果たす役割,
荒瀬美晴, 中西信人, 堤理恵, 待田京香, 新井悠太, 阪上浩, 大藤純 :
急性心筋梗塞診断における尿中タイチンの有用性評価．,
第49回日本集中治療医学会学術集会, 2022年3月. 和田安純, 黒田雅士, 田村優実, 茶本凜, 富永玲奈, 小林久呂枝, 松村英里佳, 瀧下美由紀, 藤田めい, 堤理恵, 阪上浩 :
脂肪組織由来MFG-E8はNASHでの肝慢性炎症・線維化を促進する,
第42回日本肥満学会, 2022年3月. 黒田雅士, 富永玲奈, 田村優実, 茶本凜, 松村英里佳, 小林久呂枝, 和田安純, 瀧下美由紀, 藤田めい, 志内哲也, 堤理恵, 阪上浩 :
エネルギー代謝調節機構における転写因子IRF7生理的意義の検討,
第25回アディポサイエンス・シンポジウム, 2022年2月. 田中寛人, 堤理恵, 大江健一, 卯川裕一, 向井理恵 :
廃用性筋萎縮からの回復を促進する8-プレニルナリンゲニンがアミノ酸動態に与える影響について,
支部創立20周年記念日本農芸化学会中四国支部第61回支部講演会(例会), 2022年1月. 田中寛人, 堤理恵, 向井理恵 :
骨格筋量の調節に寄与するポリフェノールがアミノ酸動態に与える影響について,
第6回メタボローム解析シンポジウム(徳島大学医学部医科栄養学科メタボローム解析室), 2021年10月. 黒田雅士, 茶本凜, 田村優実, 富永玲奈, 小林久呂枝, 松村英里佳, 和田安純, 瀧下美由紀, 藤田めい, 堤理恵, 阪上浩 :
DNAメチル化による熱産生関連遺伝子制御機構の検討,
第 54 回日本栄養•食糧学会中国•四国支部大会, 2021年10月. 和田安純, 茶本凜, 田村優実, 富永玲奈, 小林久呂枝, 松村英里佳, 瀧下美由紀, 藤田めい, 黒田雅士, 堤理恵, 阪上浩 :
NASH病態形成における脂肪組織由来分泌タンパク質MFG-E8の関与,
第263回徳島医学会, 2021年8月. 黒田雅士, 茶本凜, 富永玲奈, 田村優実, 松村英里佳, 小川美季, 堤理恵, 阪上浩 :
DNAメチル化による脂肪細胞機能制御についての検討,
第64回日本糖尿病学会年次学術集会, 2021年5月. 出葉祥恵, 山下果穂, 竹治香菜, 山崎幸, 黒田雅士, 堤理恵, 阪上浩 :
ストレプトゾトシン抵抗性ラットに認められた消化管・膵臓連関,
糖尿病, Vol.64, No.Suppl.1, III-94-6, 2021年5月. 三島優奈, 堤理恵, 大谷環樹, 原加奈子, 藤本紗織, 黒田雅士, 阪上浩 :
PET/CTを用いたマウス骨格筋インスリン抵抗性の評価,
第41回日本肥満学会, 2021年3月. 岡松優子, 黒田雅士, 堤理恵, 坪田あゆみ, 斉藤昌之, 木村和弘, 阪上浩 :
マウス褐色脂肪組織において寒冷刺激により誘導されるUCP1依存的および非依存的代謝変化,
第41回日本肥満学会, 2021年3月. 松村英里佳, 黒田雅士, 富永玲奈, 田村優実, 茶本凜, 小林久呂枝, 和田安純, 瀧下美由紀, 藤田めい, 志内哲也, 堤理恵, 阪上浩 :
転写因子IRF7によるエネルギー代謝調節機構の解明,
第42回日本肥満学会, 2021年3月. 中西信人, 堤理恵, 上野義豊, 田根なつ紀, 綱野祐美子, 板垣大雅 :
「筋萎縮ゼロプロジェクト:PICS予防のための取り組み」,
日本集中治療医学会雑誌, 2021年2月. 原加奈子, 堤理恵, 三島優奈, 待田京香, 阪上浩, 中西信人, 大藤純 :
重症患者における筋萎縮と尿中タイチン濃度に関する検討,
四国医学雑誌, Vol.76, No.5-6, 341, 2020年12月.

(キーワード): *筋萎縮症(診断) / 病勢悪化 / Connectin(尿) / ヒト

堤理恵, 阪上浩, 敷島康普, 三浦宏之 :
スダチ果皮エキス末の継続摂取が内臓脂肪に与える影響についてのランダム化二重盲検介入試験,
四国医学雑誌, Vol.76, No.5-6, 341-342, 2020年12月.

(キーワード): 植物抽出物(治療的利用) / 二重盲検法 / ミカン属(治療的利用) / ランダム化比較試験 / メタボリックシンドローム(食事療法,X線診断) / 腹腔内脂肪(X線診断) / ヒト / 男 / 女

三島優奈, 堤理恵, 黒田雅士, 阪上浩, 大谷環樹 :
PET/CTを用いたマウス骨格筋インスリン抵抗性の評価,
四国医学雑誌, Vol.76, No.5-6, 342, 2020年12月.

(キーワード): *インスリン抵抗性(実験的) *骨格筋(X線診断,放射性核種診断) *PET-CT検査マウス動物

堤理恵, 福永佳容子, 阿久根愛実, 植木歩夢, 黒井俊哉, 藤田智子, 小瀧歩, 工藤千秋, 阪上浩 :
認知症患者の栄養管理の問題点と工夫早期認知機能低下高齢者に認められる食の変化,
学会誌JSPEN, Vol.2, No.Suppl.1, 153, 2020年11月.

(キーワード): *食行動 *認知機能低下食物摂取頻度調査ヒト中年(45~64) 高齢者(65~79) 高齢者(80~)

堤理恵, 山本智子, 橘高久未子, 中西信人, 阪上浩 :
重症患者の栄養代謝病態と栄養療法の実際重症病態における糖・アミノ酸代謝動態の解明,
学会誌JSPEN, Vol.2, No.Suppl.1, 187, 2020年11月.

(キーワード): *Amino Acids ICU 敗血症(実験的) *タンパク質代謝 *糖代謝メタボロミクスヒトマウス動物高齢者(65~79) 男女

別府香名, 堤理恵, 瀬部真由, 阪上浩 :
食道がん・頭頸部がん患者における安静時エネルギー消費量と食事摂取量および体組成の関係性,
学会誌JSPEN, Vol.2, No.Suppl.1, 252, 2020年11月.

(キーワード): *基礎代謝 *食行動 *食道腫瘍 *頭頸部腫瘍 *身体組成ヒト中年(45~64) 高齢者(65~79)

瀬部真由, 堤理恵, 瀬野浦聖佳, 岸潤, 黒田雅士, 木下成三, 中屋豊, 堤保夫, 西岡安彦, 阪上浩 :
脂質の過剰摂取は関節リウマチ病態の増悪・骨格筋量の減少を引き起こす,
学会誌JSPEN, Vol.2, No.Suppl.1, 824, 2020年11月.

(キーワード): *関節リウマチ(病因,合併症,実験的) 食品中の脂肪(毒性・副作用) 病勢悪化 *筋肉減少症(病因,合併症,実験的) *高脂肪食(有害作用) ヒトマウス動物中年(45~64) 女

遠藤亜紀, 松岡百百世, 高岡司, 堤理恵, 阪上浩, 武田憲昭 :
難治性亜鉛欠乏性味覚障害患者に対するツイントース併用亜鉛補充療法の効果,
第121回日本耳鼻咽喉科学会学術講演会, 2020年10月. 庄野仁志, 堤理恵, 金村亮, 大西皓貴, 佐藤豪, 北村嘉章, 阿部晃治, 阪上浩, 武田憲昭 :
食事へのグルタミン酸Na 添加が頭頸部癌患者の化学療法による舌粘膜の味覚受容体遺伝子発現に与える影響,
第121回日本耳鼻咽喉科学会学術講演会, 2020年10月. 徳里望, 堤理恵, 黒田雅士, 升本早枝子, 庄野仁志, 阿部亮, 大西皓貴, 佐藤豪, 北村嘉章, 阿部晃治, 阪上浩, 武田憲昭 :
食事へのグルタミン酸Na添加が頭頸部癌患者の化学療法による舌粘膜の味覚受容体遺伝子発現に与える影響,
日本耳鼻咽喉科学会会報, Vol.123, No.4, 1065, 2020年9月.

(キーワード): *Catechin *肥満(実験的) *Biflavonoids *Proanthocyanidins *認知機能低下(実験的) 消化管微生物叢 *Procyanidin マウス動物 / *Sodium Glutamate(治療的利用,薬理学) *遺伝子発現 *口腔粘膜抗腫瘍剤(治療的利用,毒性・副作用) *頭頸部腫瘍(薬物療法) 味覚障害(化学的誘発,薬物療法) *味蕾 *舌粘膜ヒト

徳里望, 阪上浩, 堤理恵, 黒田雅士, 升本早枝子, 河相舞香, 竹治香菜, 山崎幸, 松本裕華, 堤理恵, 黒田雅士, 阪上浩 :
ストレプトゾトシン抵抗性ラットにおける膵β細胞保護因子の探索,
糖尿病, Vol.63, No.9, 642, 2020年9月.

(キーワード): *Catechin *肥満(実験的) *Biflavonoids *Proanthocyanidins *認知機能低下(実験的) 消化管微生物叢 *Procyanidin マウス動物 / Insulin *Streptozocin(毒性・副作用) 薬物抵抗性 *細胞保護 *インスリン分泌細胞 Ghrelin(血液) Glucagon-Like Peptide 1(血液) ラット動物

徳里望, 阪上浩, 堤理恵, 黒田雅士, 升本早枝子, 原加奈子, 堤理恵, 三島優奈, 松本裕華, 黒田雅士, 大谷環樹, 阪上浩 :
PET/CTを用いた代謝性疾患モデルマウス骨格筋糖取り込みの評価,
糖尿病, Vol.63, No.9, 649, 2020年9月.

(キーワード): *Catechin *肥満(実験的) *Biflavonoids *Proanthocyanidins *認知機能低下(実験的) 消化管微生物叢 *Procyanidin マウス動物 / *高インスリン症(実験的) 疾患モデル(動物) *骨格筋(X線診断,放射性核種診断) Fluorodeoxyglucose F18(診断的利用) PET-CT検査マウス動物オス

徳里望, 阪上浩, 堤理恵, 黒田雅士, 升本早枝子, 森万理恵, 別府香名, 堤理恵, 森博康, 松久宗英, 阪上浩, 神田彩恵, 堤理恵, 三島優奈, 上嶋奈々子, 松本裕華, 原加奈子, 黒田雅士, 阪上浩 :
ロイシンの抗動脈硬化作用の検討,
糖尿病, Vol.63, No.9, 657, 2020年9月.

(キーワード): *Catechin *肥満(実験的) *Biflavonoids *Proanthocyanidins *認知機能低下(実験的) 消化管微生物叢 *Procyanidin マウス動物 / 血液透析糸球体濾過量 *腎不全-慢性(治療,合併症) *糖尿病(合併症) *味覚障害(病因) *味蕾 Leptin(血液) G-Protein-Coupled Receptors T1R Receptor ヒト / Cholesterol(血液) *Leucine(治療的利用) LDL Cholesterol(血液) *動脈硬化症(薬物療法,実験的) マウス動物メス

徳里望, 阪上浩, 堤理恵, 黒田雅士, 升本早枝子, 岡本彩椰, 黒田雅士, 川端康代, 田村優実, 富永玲奈, 堤理恵, 阪上浩 :
NASH病態形成における脂肪組織由来分泌タンパク質MFG-E8の関与,
糖尿病, Vol.63, No.9, 668, 2020年9月.

(キーワード): *Catechin *肥満(実験的) *Biflavonoids *Proanthocyanidins *認知機能低下(実験的) 消化管微生物叢 *Procyanidin マウス動物 / Aspartate Aminotransferases(血液) *表面抗原脂肪組織糖尿病(合併症) *乳タンパク質肝線維症 *肝疾患-非アルコール性脂肪性(実験的,合併症) *MFGE8 Protein マウス動物

徳里望, 阪上浩, 堤理恵, 黒田雅士, 升本早枝子, 瀬部真由, 堤理恵, 黒田雅士, 阪上浩 :
高脂肪食摂取が関節リウマチ病態に与える影響,
糖尿病, Vol.63, No.9, 668, 2020年9月.

(キーワード): *Catechin *肥満(実験的) *Biflavonoids *Proanthocyanidins *認知機能低下(実験的) 消化管微生物叢 *Procyanidin マウス動物 / *関節リウマチ(実験的) 肥満 CD4陽性T細胞リスク評価 Interleukin-17 *高脂肪食マウス動物

徳里望, 阪上浩, 堤理恵, 黒田雅士, 升本早枝子 :
リンゴ由来プロシアニジンの摂取が老化モデルマウスの肥満・認知機能に及ぼす影響,
糖尿病, Vol.63, No.9, 668, 2020年9月.

(キーワード): *Catechin *肥満(実験的) *Biflavonoids *Proanthocyanidins *認知機能低下(実験的) 消化管微生物叢 *Procyanidin マウス動物

堤理恵, 山本智子, 中西信人, 阪上浩 :
侵襲時における臓器障害連関を科学する~基礎から臨床まで~ 侵襲時における臓器連関による糖・アミノ酸代謝制御機構の解明,
日本集中治療医学会雑誌, Vol.27, No.Suppl., 277, 2020年9月.

(キーワード): *Amino Acids 肝臓骨格筋 *糖代謝ヒトマウス動物中年(45~64) 高齢者(65~79) 高齢者(80~) 男女

中西信人, 堤理恵, 原加奈子, 山本智子, 綱野祐美子, 中瀧恵実子, 板垣大雅, 松尾雅文, 阪上浩, 大藤純 :
侵襲時における臓器障害連関を科学する~基礎から臨床まで~ ICU入室患者における筋萎縮と尿中タイチン濃度に関する検討,
日本集中治療医学会雑誌, Vol.27, No.Suppl., 277, 2020年9月.

(キーワード): *ICU *筋萎縮症(超音波診断) *Connectin(尿) ヒト中年(45~64) 高齢者(65~79) 高齢者(80~)

堤理恵, 山本智子, 中西信人, 阪上浩 :
重症患者に対する栄養療法の工夫と実践重症患者の栄養管理におけるBIAの意義と活用の検討,
日本集中治療医学会雑誌, Vol.27, No.Suppl., 317, 2020年9月.

(キーワード): *インピーダンス *身体組成 *栄養管理ヒト男女

徳里望, 阪上浩, 堤理恵, 黒田雅士, 升本早枝子, 原加奈子, 堤理恵, 中西信人, 阪上浩 :
【重症患者の長期予後を見据えた栄養療法と運動療法】重症病態における代謝変化とアミノ酸代謝の見解,
外科と代謝·栄養, Vol.54, No.3, 143-146, 2020年8月.

(要約): 熱傷や多発外傷，敗血症といった重症病態では，健常時と比較して代謝動態は著しく変化する．侵襲時での炎症性サイトカインや免疫細胞の活性化によって解糖経路の亢進やミトコンドリアの機能不全による酸化的リン酸化の抑制が生じる．このような代謝の変化によってエネルギー代謝の倹約と乳酸の過剰産生が示唆される．また，代謝動態への影響は糖代謝のみではなくアミノ酸代謝にも及ぶ．特に分岐鎖アミノ酸(BCAA)の代謝動態は重要なシグナル因子となっている可能性が考えられる．敗血症においては，骨格筋でのロイシン抵抗性が懸念されるが，一方でロイシンの投与によって骨格筋減少抑制効果があることも報告されている．重症病態において代謝機構の変化に合わせたエネルギー投与量の調整ともに，アミノ酸代謝の意義を究明する必要がある．(著者抄録)
(キーワード): *Catechin *肥満(実験的) *Biflavonoids *Proanthocyanidins *認知機能低下(実験的) 消化管微生物叢 *Procyanidin マウス動物 / *Amino Acids(血液) Branched-Chain Amino Acids 運動療法活性酸素筋萎縮症(予防) *代謝栄養管理ヒト

堤理恵, 敷島康普, 三浦宏之, 阪上浩 :
スダチ果皮エキスによるメタボリックシンドローム予防効果のランダム化二重盲検試験,
糖尿病, Vol.63, No.Suppl.1, S-180, 2020年8月.

(キーワード): *植物抽出物(治療的利用) 二重盲検法 *ミカン属(治療的利用) 治療成績ランダム化比較試験 *メタボリックシンドローム(予防,薬物療法,予後) ヒト男女

瀬部真由, 堤理恵, 瀬野浦聖佳, 岸潤, 黒田雅士, 木下成三, 中屋豊, 堤保夫, 西岡安彦, 阪上浩 :
飽和脂肪酸の過剰摂取は関節リウマチ病態の増悪・骨格筋量の減少を引き起こす,
糖尿病, Vol.63, No.Suppl.1, S-329, 2020年8月.

(キーワード): *関節リウマチ(食事療法) *脂肪酸(毒性・副作用) 骨格筋病勢悪化 *筋肉減少症(化学的誘発) 筋量ヒト女

徳里望, 阪上浩, 堤理恵, 黒田雅士, 升本早枝子, 堤理恵, 瀬部真由, 岸潤, 木下成三, 西岡安彦, 阪上浩 :
飽和脂肪酸の過剰摂取は関節リウマチ病態の増悪・骨格筋量の減少を引き起こす,
日本臨床分子医学会学術総会プログラム・抄録集, No.9, 75, 2020年4月.

(キーワード): *Catechin *肥満(実験的) *Biflavonoids *Proanthocyanidins *認知機能低下(実験的) 消化管微生物叢 *Procyanidin マウス動物 / *関節リウマチ(病因) *脂肪酸骨格筋病勢悪化 *筋肉減少症(病因) 高脂肪食ヒトマウス動物女

徳里望, 阪上浩, 堤理恵, 黒田雅士, 升本早枝子, 瀬部真由, 堤理恵, 瀬野浦聖佳, 黒田雅士, 中屋豊, 阪上浩, 岸潤, 木下成三, 堤保夫, 西岡安彦 :
飽和脂肪酸の過剰摂取は関節リウマチを増悪させ骨格筋量の減少を引き起こす,
四国医学雑誌, Vol.76, No.1-2, 120-121, 2020年4月.

(キーワード): *Catechin *肥満(実験的) *Biflavonoids *Proanthocyanidins *認知機能低下(実験的) 消化管微生物叢 *Procyanidin マウス動物 / 栄養評価 *関節リウマチ(実験的,合併症,診断) *脂肪酸(薬理学) *骨格筋身体組成筋肉減少症(実験的,合併症,診断) ヒトマウス動物中年(45~64) 女

徳里望, 阪上浩, 堤理恵, 黒田雅士, 升本早枝子, 武田英二, 佐藤美智子, 隅田奈美, 久米寛子, 大前博司, 森下照大, 川浦昭彦, 片山貴文, 堤理恵, 阪上浩, 竹谷豊 :
骨格筋肉量，機能，栄養素吸収におよぼす1日1000IUのビタミンD摂取効果,
ビタミン, Vol.94, No.4, 277, 2020年4月.

(キーワード): *Catechin *肥満(実験的) *Biflavonoids *Proanthocyanidins *認知機能低下(実験的) 消化管微生物叢 *Procyanidin マウス動物 / Hydroxycholecalciferols(血液) *Vitamin D(薬理学) *筋骨格系生理学的現象乳 *骨格筋 *身体組成 *生理的吸収 *筋量ヒト成人(19~44) 中年(45~64) 高齢者(65~79) 男女

堤理恵 :
重症患者における栄養療法,
日本集中治療医学会, 2020年3月. 堤理恵 :
高齢者の認知機能とタンパク質の必要性,
日本臨床栄養代謝学会, 2020年2月. 瀬部真由, 堤理恵, 瀨野浦聖佳, 岸潤, 黒田雅士, 木下成三, 中屋豊, 堤保夫, 西岡安彦, 阪上浩 :
飽和脂肪酸の過剰摂取は関節リウマチ病態の憎悪・骨格筋量の減少を引き起こす,
第23回日本病態栄養学会年次学術集会, 2020年1月. 徳里望, 阪上浩, 堤理恵, 黒田雅士, 升本早枝子, 瀬部真由, 堤理恵, 瀬野浦聖佳, 岸潤, 黒田雅士, 木下成三, 中屋豊, 堤保夫, 西岡安彦, 阪上浩 :
飽和脂肪酸の過剰摂取は関節リウマチ病態の増悪・骨格筋量の減少を引き起こす,
日本病態栄養学会誌, Vol.23, No.Suppl., S-1, 2020年1月.

(キーワード): *Catechin *肥満(実験的) *Biflavonoids *Proanthocyanidins *認知機能低下(実験的) 消化管微生物叢 *Procyanidin マウス動物 / *関節リウマチ(化学的誘発,実験的) 危険因子 *脂肪酸(毒性・副作用) 骨格筋病勢悪化 *過栄養(化学的誘発,実験的) *筋肉減少症(化学的誘発,実験的) 筋量マウス動物

徳里望, 阪上浩, 堤理恵, 黒田雅士, 升本早枝子, 阿久根愛実, 堤理恵, 植木歩夢, 瀬部真由, 黒井俊哉, 藤田智子, 小瀧歩, 工藤千秋, 阪上浩 :
認知機能低下と食事摂取・口腔細菌叢の関連性の検討,
日本病態栄養学会誌, Vol.23, No.Suppl., S-46, 2020年1月.

(キーワード): *Catechin *肥満(実験的) *Biflavonoids *Proanthocyanidins *認知機能低下(実験的) 消化管微生物叢 *Procyanidin マウス動物 / *細菌 *食行動食肉食品中のタンパク質無機栄養素野菜 *認知機能低下(予防,診断) *消化管微生物叢 *口腔内細菌ヒト中年(45~64) 高齢者(65~79) 高齢者(80~) 男女

徳里望, 阪上浩, 堤理恵, 黒田雅士, 升本早枝子, 三島優奈, 堤理恵, 松本裕華, 原加奈子, 大谷環樹, 上嶋菜々子, 神田彩恵, 黒田雅士, 阪上浩 :
廃用性筋萎縮モデルにおける骨格筋・肝代謝動態の連関による生体機能制御,
日本病態栄養学会誌, Vol.23, No.Suppl., S-54, 2020年1月.

(キーワード): *Catechin *肥満(実験的) *Biflavonoids *Proanthocyanidins *認知機能低下(実験的) 消化管微生物叢 *Procyanidin マウス動物 / 遺伝子発現エネルギー代謝 *筋萎縮症(実験的) *骨格筋 *糖代謝 *廃用症候群(実験的) Large Neutral Amino Acid-Transporter 1 マウス動物

徳里望, 阪上浩, 堤理恵, 黒田雅士, 升本早枝子, 橘高久未子, 山本智子, 堤理恵, 中西信人, 阪上浩 :
重症病態における血中遊離アミノ酸の意義,
日本病態栄養学会誌, Vol.23, No.Suppl., S-57, 2020年1月.

(キーワード): *Catechin *肥満(実験的) *Biflavonoids *Proanthocyanidins *認知機能低下(実験的) 消化管微生物叢 *Procyanidin マウス動物 / *Amino Acids ICU *エネルギー代謝前向き研究 *メタボロミクスヒト中年(45~64) 高齢者(65~79) 高齢者(80~) 男女

徳里望, 阪上浩, 堤理恵, 黒田雅士, 升本早枝子, 竹治香菜, 山崎幸, 河相舞香, 松本裕華, 黒田雅士, 堤理恵, 阪上浩 :
ストレプトゾトシン抵抗性ラットにおける膵β細胞保護因子の探索,
日本病態栄養学会誌, Vol.23, No.Suppl., S-57, 2020年1月.

(キーワード): *Catechin *肥満(実験的) *Biflavonoids *Proanthocyanidins *認知機能低下(実験的) 消化管微生物叢 *Procyanidin マウス動物 / *Streptozocin(毒性・副作用) *糖尿病(実験的) 薬物抵抗性 *インスリン分泌細胞 *Glucagon-Like Peptide 1(血液) ラット動物

竹治香菜, 山崎幸, 河相舞香, 松本裕華, 黒田雅士, 堤理恵, 阪上浩 :
ストレプドゾトシン抵抗性ラットにおける膵β細胞保護因子の探索,
第23回日本病態栄養学会年次学術集会, 2020年1月. 三島優奈, 堤理恵, 松本裕華, 原加奈子, 大谷環樹, 上嶋菜々子, 神田彩恵, 黒田雅士, 阪上浩 :
廃用性筋萎縮モデルにおける骨格筋・艦隊者動態の連関による生体機能制御,
第23回日本病態栄養学会年次学術集会, 2020年1月. 森万理江, 別府香名, 堤理恵, 森博康, 松久宗英, 阪上浩 :
糖尿病および透析患者における味覚障害と舌味覚受容体発言の関連について,
日本糖尿病学会中国四国地方会第57回総会, 2019年12月. 田中寛人, 西海信, 堤理恵, 向井理恵 :
筋タンパク質合成時にプレニルナリンゲニンが引き起こす骨格筋内代謝物の変動,
第13回日本ポリフェノール学会・第16回日本カテキン学会合同学術集会, 2019年11月. 堤理恵, 瀬部真由, 岸潤, 瀨野浦聖佳, 黒田雅士, 西岡安彦, 阪上浩 :
飽和脂肪酸はインスリン抵抗性誘導を介して慢性関節リウマチを増悪させる,
第40回日本肥満学会, 2019年11月. 川端康代, 黒田雅士, 岡本彩椰, 田村優実, 富永玲奈, 堤理恵, 阪上浩 :
エネルギー代謝調節機構における転写因子IRF7の役割,
第40回日本肥満学会, 2019年11月. 竹治香菜, 山崎幸, 河相舞香, 松本裕華, 黒田雅士, 堤理恵, 阪上浩 :
ストレプトゾトシン抵抗性ラットにおける膵β細胞保護因子の探索,
第40回日本肥満学会, 2019年11月. 武田憲昭, 高岡司, 堤理恵, 阪上浩 :
難治性亜鉛欠乏性味覚障害患者に対するツイントース併用亜鉛補充療法の効果,
第32回日本口腔咽頭科学会, 2019年9月. 庄野仁志, 堤理恵, 阪上浩, 合田正和, 武田憲昭 :
シスプラチンによる舌粘膜の味覚受容体発現低下とグルコサミン酸Naの食事への添加の効果,
第32回日本口腔咽頭科学会, 2019年9月. 川端康代, 黒田雅士, 岡本彩椰, 田村優実, 富永玲奈, 堤理恵, 阪上浩 :
エネルギー代謝調節機構における転写因子IRF7の役割,
第24回アディポサイエンス・シンポジウム, 2019年8月. 堤理恵 :
栄養でがん患者を支える,
日本静脈経腸栄養学会, 2019年6月. 徳里望, 阪上浩, 堤理恵, 黒田雅士, 升本早枝子, 阪上浩, 堤理恵 :
肥満をもう一度考える:新たな肥満症から治療まで肥満から読み解く高齢者栄養の問題点と管理の実際,
日本抗加齢医学会総会プログラム・抄録集, No.9, 137, 2019年6月.

(キーワード): *Catechin *肥満(実験的) *Biflavonoids *Proanthocyanidins *認知機能低下(実験的) 消化管微生物叢 *Procyanidin マウス動物 / 危険因子 *肥満(合併症,治療) *栄養管理筋肉減少症(合併症,治療) *認知機能低下(病因,治療) *フレイル(病因,治療) ヒト高齢者(65~79) 高齢者(80~)

山田美鈴, 黒田暁生, 堤理恵, 冨永ゆかり, 阪上浩, 松久宗英 :
循環血中遊離DNAを標的とした血管内皮細胞傷害の検出,
第62回日本糖尿病学会年次学術集会, 2019年5月. 堤理恵 :
小型魚類を用いた味覚感知機序の解明,
日本栄養食糧学会, 2019年5月. 堤理恵 :
急性期の栄養療法と栄養剤の選択,
関西心不全研究会, 2019年5月. 川端康代, 黒田雅士, 宇川菜穂, 石川悦子, 岡本彩椰, 佐々木和佳, 升本早枝子, 堤理恵, 阪上浩 :
肥大化脂肪細胞における転写因子IRF7の同定と生理的役割の検討,
第62回日本糖尿病学会, 2019年5月. 三島優奈, 堤理恵, 宮武由実子, 末政直哉, 大谷環樹, 兒玉直子, 丹波洋介, 黒田雅士, 升本早枝子, 阪上浩 :
PET/CTを用いた代謝異常時の骨格筋における糖取り込みの測定,
第62回日本糖尿病学会, 2019年5月. 黒田雅士, 石川悦子, 宇川菜穂, 岡本彩椰, 川端康代, 佐々木和佳, 升本早枝子, 堤理恵, 阪上浩 :
脂肪組織慢性炎症及びNASH病態形成における分泌タンパク質MFG-E8の関与,
第62回日本糖尿病学会, 2019年5月. 堤理恵 :
急性期栄養療法,
長崎県NST講演会, 2019年4月. 堤理恵 :
PETCTによる筋代謝評価の確立,
MDF研究会, 2019年4月. 別府香名, 堤理恵, 森博康, 平野春美, 土田健司, 松久宗英, 武田憲昭, 阪上浩 :
透析患者における味覚障害と味覚受容体T1R3遺伝子の発現の関連,
第258回徳島医学会学術集会ポスターセッション, 2019年2月. 堤理恵, 山本智子, 中西信人, 阪上浩 :
敗血症における代謝破綻と血中遊離アミノ酸の意義,
日本集中治療医学会雑誌, Vol.26, No.Suppl., [O75-1], 2019年2月. 堤理恵 :
がん患者と味覚障害,
日本病態栄養学会学術集会, 2019年1月. 堤理恵 :
PET-CTによる筋代謝評価,
2019年1月. 佐々木和佳, 黒田雅士, 石川悦子, 宇川菜穂, 川端康代, 升本早枝子, 堤理恵, 阪上浩 :
脱メチル化3T3-L1脂肪細胞のインスリン感受性調節因子の探索,
第39回日本肥満学会, 2018年10月. 川端康代, 黒田雅士, 石川悦子, 宇川菜穂, 佐々木和佳, 升本早枝子, 堤理恵, 阪上浩 :
肥大化脂肪細胞における転写因子IRF7の同定と生理的役割の検討,
第39回日本肥満学会, 2018年10月. 與儀耕大, 谷口早紀, 宮崎厚子, 一宮由貴, 三木幸代, 堤理恵, 大森哲郎 :
徳島大学病院がんサロンの活動報告と今後の展望,
第31回日本サイコオンコロジー学会総会, 2018年9月. 黒田雅士, 宇川菜穂, 石川悦子, 川端康代, 佐々木和佳, 升本早枝子, 堤理恵, 阪上浩 :
エネルギー代謝における転写因子IRF7の役割,
第23回アディポサイエンス・シンポジウム, 2018年8月. 宇川菜穂, 黒田雅士, 石川悦子, 升本早枝子, 堤理恵, 原田永勝, 阪上浩 :
肥大化脂肪細胞における転写因子 IRF7 の同定と機能解析,
第61回日本糖尿病学会, 2018年5月. 黒田雅士, 石川悦子, 宇川菜穂, 升本早枝子, 堤理恵, 原田永勝, 阪上浩 :
脂肪組織慢性炎症及びNASH病態形成に対するMFG-E8の関与,
第61回日本糖尿病学会, 2018年5月. Masashi Kuroda, Etsuko Ishikawa, Naho Ugawa, Saeko Masumoto, Rie Tsutsumi, Nagakatsu Harada and Hiroshi Sakaue :
Adipose tissue-derived protein, MFG-E8, regulates chronic inflammation and obesity-related liver disease,
第91回日本内分泌学会, Apr. 2018. 井内茉莉奈, 堤理恵, 中西信人, 山本智子, 田中志歩, 大藤純, 中瀧恵実子, 小野寺睦雄, 阪上浩, 西村匡司 :
重症患者におけるエネルギー代謝動態の解析．,
第45回日本集中治療医学会学術集会, 2018年2月. 堤理恵, 竹尾仁良, 板東正浩, 瀬部真由, 山﨑幸, 丹波洋介, 宮原裕子, 黒田雅士, 升本早枝子, 原田永勝, 阪上浩 :
魚油由来長鎖モノエン脂肪酸の上腕動脈内皮機能に与える効果の検討,
第38回日本肥満学会, 2017年10月. 小野山瑠美, 黒田雅士, 西口実佐, 宇川菜穂, 石川悦子, 升本早枝子, 堤理恵, 原田永勝, 阪上浩 :
転写制御領域解析システムを用いた3T3-L1脂肪細胞のインスリン感受性調節因子の探索,
第38回日本肥満学会, 2017年10月. 石川悦子, 黒田雅士, 西口実佐, 小野山瑠美, 宇川菜穂, 升本早枝子, 堤理恵, 原田永勝, 阪上浩 :
脂肪組織慢性炎症及びNASH病態形成に対するMFG-E8の関与,
第38回日本肥満学会, 2017年10月. 庄野仁志, 武田憲昭, 合田正和, 堤理恵, 阪上浩 :
食事へのグルタミン酸Na 添加が化学療法による舌の味覚受容体遺伝子発現に与える影響,
第30 回日本口腔・咽頭科学, 2017年9月. 黒田雅士, 西口実佐, 小野山瑠美, 宇川菜穂, 石川悦子, 升本早枝子, 堤理恵, 原田永勝, 阪上浩 :
脂肪細胞における転写因子IRF7の同定及び機能解析,
第22回アディポサイエンス・シンポジウム, 2017年8月. 庄野仁志, 合田正和, 阿部晃治, 堤理恵, 酒井徹, 武田憲昭 :
頭頸部癌患者に対する化学療法が舌の味覚受容体遺伝子発現に与える影響,
第42回日本外科系連合学会学術集会, 2017年6月. 西口実佐, 黒田雅士, 小野山瑠美, 宇川菜穂, 堤理恵, 原田永勝, 阪上浩 :
肥大化脂肪細胞における転写因子IRF7の同定と機能解析,
第60回日本糖尿病学会年次学術集会, 2017年5月. 小野山瑠美, 黒田雅士, 西口実佐, 宇川菜穂, 堤理恵, 原田永勝, 阪上浩 :
3T3-L1脂肪細胞のインスリン感受性に対するDNAメチル化の制御機構,
第60回日本糖尿病学会年次学術集会, 2017年5月. 黒田雅士, 西口実佐, 小野山瑠美, 宇川菜穂, 堤理恵, 原田永勝, 阪上浩 :
新規肥満関連転写因子IRF7によるMCP-1発現制御機構の解析,
第90回日本内分泌学会学術集会, 2017年4月. 井内茉莉奈, 堤理恵, 中西信人, 大藤純, 中瀧恵実子, 小野寺睦雄, 阪上浩, 西村匡司 :
重症患者における栄養投与開始時期と体組成変化の関連性の検討．,
第44回日本集中治療医学会学術集会, 2017年3月. 中西信人, 堤理恵, 大藤純, 井内茉莉奈, 上野義豊, 西川真理恵, 綱野祐美子, 中瀧恵実子, 小野寺睦雄, 西村匡司 :
超音波によるICU患者の上肢・下肢筋委縮評価．,
第44回日本集中治療医学会学術集会, 2017年3月. 堤理恵, 堤保夫, 西村匡司 :
ペプチド栄養剤の最新情報．,
第44回日本集中治療医学会学術集会, 2017年3月. 丹波洋介, 竹尾仁良, 板東正浩, 瀬部真由, 山崎幸, 福田大受, 宮原裕子, 宮武由実子, 末政直哉, 黒田雅士, 升本早枝子, 原田永勝, 堤理恵, 佐田政隆, 阪上浩 :
魚油由来長鎖モノエン脂肪酸は抗動脈硬化作用を有する,
第21回病態栄養学会年次学術集会, 2017年1月. 安井苑子, 谷村真優, 松原あつみ, 堤理恵, 谷佳子, 松村晃子, 島田亜紀, 阪上浩, 武田憲昭, 濵田康弘 :
頭頸部癌化学放射線療法において治療開始時のクレアチニン身長係数が有害事象や治療中断にあたえる影響,
第31回日本静脈経腸栄養学会, 2016年2月. 井内茉莉奈, 大藤純, 堤理恵, 小野寺睦雄, 阪上浩, 今中秀光, 西村匡司 :
重症患者における栄養予後指標としての位相角の有用性．,
第43回日本集中治療医学会学術集会, 2016年2月. 堤理恵, 大藤純, 井内茉莉奈, 小野寺睦雄, 堤保夫, 今中秀光, 原田永勝, 西村匡司 :
ICU入室中の筋肉量減少と予後の関連性,
第43回日本集中治療医学会学術集会, 2016年2月. 久保みゆ, 安井苑子, 谷村真優, 松原あつみ, 堤理恵, 谷佳子, 松村晃子, 島田亜紀, 阪上浩, 武田憲昭, 濵田康弘 :
頭頸部癌化学放射線療法において治療開始時のクレアチニン身長係数が有害事象に与える影響,
第19回日本病態栄養学会, 2016年1月. 坂口真由香, 秦明子, 四釜洋介, 安藝菜奈子, 酒井徹, 首藤恵泉, 堤理恵, 中尾隆之, 三好雅士, 船木真理, 米本孝二 :
Reduced Rank Regressionにより抽出された食事パターンの一般化可能性に関する検討∼メタボリックシンドローム発症追跡データを用いて∼,
糖尿病, Vol.58, No.Suppl.1, 2015年5月. 堤理恵, 大藤純, 小野寺睦雄, 今中秀光, 西村匡司 :
重症患者におけるインピーダンス測定の有効性の検討．,
第42回日本集中治療医学会学術集会, 2015年2月. 堤理恵 :
重症患者の栄養療法:日本外科感染症学会,
2014年12月. 合田正和, 北村嘉章, 高橋美香, 島谷美映, 堤理恵, 酒井徹, 武田憲昭 :
頭頸部癌化学療法が舌の味覚受容体遺伝子発現に及ぼす影響,
日本耳鼻咽喉科学会第39回四国四県地方部会連合学会, 2013年12月. 合田正和, 堤理恵, 藤本知佐, 酒井徹, 武田憲昭 :
頭頸部癌化学療法が舌の味覚受容体遺伝子発現に及ぼす影響,
第26回日本口腔・咽頭科学会, 2013年9月. 秦明子, 坂東由記子, 四釜洋介, 安藝菜奈子, 小杉知里, 西村美穂, 阿部房代, 佐藤美子, 中奥真理子, 片山りか, 赤松康代, 酒井徹, 首藤恵泉, 堤理恵, 田村綾子, 市原多香子, 南川貴子, 桑村由美, 中尾隆之, 三好雅士, 森口博基, 玉木悠, 松本俊夫, 船木真理 :
徳島県におけるadiponectinや高感度CRPとメタボリックシンドロームとの関連,
糖尿病, Vol.Vol.56, No.Suppl.1, S.208, 2013年5月. 秦明子, 坂東由記子, 四釜洋介, 安藝菜奈子, 小杉知里, 西村美穂, 阿部房代, 佐藤美子, 中奥真理子, 片山りか, 赤松康代, 丹下幸子, 酒井徹, 首藤恵泉, 堤理恵, 田村綾子, 市原多香子, 南川貴子, 桑村由美, 桑村由美, 中尾隆之, 三好雅士, 森口博基, 玉木悠, 松本俊夫, 船木真理 :
徳島県におけるadiponectinや高感度CRPとメタボリックシンドロームとの関連,
糖尿病, Vol.56, 2013年4月. 堤理恵, 酒井徹, 合田正和, 北村嘉章, 阿部晃治, 武田憲昭, 藤本知佐, 河合美佐, 松本英希 :
頭頸部癌の放射線・化学療法中における味覚異常と味覚受容体について,
日本耳鼻咽喉科学会徳島県地方部会第70回学術講演会, 2013年3月. 堤理恵, 堤保夫, 小野寺睦雄, 今中秀光, 西村匡司 :
救急・集中治療領域の栄養管理:問題点と対策の工夫 ICU患者における免疫修飾栄養投与の効果と使い方の検討,
第28回日本静脈経腸栄養学会, 2013年2月. 堤理恵, 堤保夫, 武川茉莉子 :
ICU患者における栄養ストレスの誘導因子の検索とそのメカニズムの解析,
第28回日本静脈経腸栄養学会, 2013年2月. 堤理恵, 堤保夫 :
周術期の栄養管理-ERASの観点から-,
第16回日本病態栄養学会, 2013年1月. 堤理恵, 武川茉莉子, 小野寺睦雄, 中瀧恵実子, 堤保夫, 田中克哉, 今中秀光, 西村匡司 :
過剰栄養がもたらす栄養ストレスとタンパク異化亢進についての検討,
第10回周術期体液・代謝・侵襲研究会, 2012年8月. 吉田知美, 笹賀早也香, 三好まどか, 堤理恵, 首藤恵泉, 保坂利男, 新居佳孝, 津嘉山正夫, 岡久修己, 岩田深也, 酒井徹 :
スダチ抽出物であるスダチチンの肥満および糖尿病予防作用,
第66回日本栄養食糧学会大会, 2012年5月. 小杉知里, 安藝菜奈子, 坂東由記子, 四釜洋介, 西村美穂, 片山りか, 丹下幸子, 阿部房代, 赤松康代, 秦明子, 木宿由佳, 篠田香織, 酒井徹, 首藤恵泉, 堤理恵, 保坂利男, 田村綾子, 市原多香子, 南川貴子, 桑村由美, 森川富昭, 玉木悠, 船木真理 :
初期糖代謝異常を発見する指標としてのIL-18測定有用性の検討,
糖尿病, Vol.Vol.55, No.Suppl.1, S.290, 2012年5月. 堤理恵, 山口想太郎, 堤保夫, 田中克哉 :
高度侵襲下におけるエネルギー平衡とタンパク代謝の検討,
第27回日本静脈経腸栄養学会, 2012年2月. 堤保夫, 堤理恵 :
早期集中治療におけるPEPTAMEN AFの有効性の検討,
第27回日本静脈経腸栄養学会, 2012年2月. 山口想太郎, 平田容子, 堤理恵, 中瀧恵実子, 堤保夫, 田中克哉, 今中秀光, 西村匡司, 中屋豊 :
ICU患者における消費エネルギー量測定による既存推定算出量の再評価,
第15回日本病態栄養学会, 2012年1月. 首藤恵泉, 荒川真衣, 田崎志保, 中本真理子, 堤理恵, 保坂利男, 酒井徹 :
食餌誘導性肥満マウスにおける大豆イソフラボンの炎症反応への影響,
第65回日本栄養食糧学会大会, 2011年5月. 堤理恵 :
徳島大学病院における術前補水食の効果の検討,
日本病態栄養学会, 2011年1月.

研究会・報告書: 研究者総覧に該当データはありませんでした。

特許: 堤理恵 : . 堤理恵, 阪上浩, 武田憲昭 : グルタミン酸を有効成分とする担がん患者の味覚及び/又は食欲障害の改善剤, . 堤理恵 : 重症病態によるアミノ酸濃度の予後予測因子, . 堤理恵, 阪上浩 : . 堤理恵, 阪上浩 : (2018年5月), (2018年11月), 特許第2017-101459 WO2018/216715A1号 (2018年11月). Rie Tsutsumi : (), (Feb. 2018), (Aug. 2019), 2019-137660 (Feb. 2018). 堤理恵 : ゆこう成分を用いた整腸剤, (2017年2月), . 阪上浩, 堤理恵, 武田憲昭, 松島里那 : グルタミン酸を有効成分とする担がん患者の味覚及び/又は食欲障害の改善剤, 特願2016-13808 (2016年1月), . 堤理恵 : スダチチンを有効成分とするメタボリック症候群予防及び改善効果, (2012年4月), 特許第2012005号. Rie Tsutsumi : -, (Apr. 2012), 2012004.
作品: 研究者総覧に該当データはありませんでした。
補助金・競争的資金: 吸入麻酔薬のSirtを介した心筋保護作用に対して高血糖状態が与える影響 (研究課題/領域番号: 22K09048 )
サルコペニアの診断と発症予防法の開発を目指した基盤・応用研究 (研究課題/領域番号: 22H03535 )
敗血症における代謝産物を介した生命維持機構の解明 (研究課題/領域番号: 21K11724 )
抗肥満作用を有する阿波すず香の新規成分の同定とその作用機序の解明 (研究課題/領域番号: 21K05450 )
抗動脈硬化作用を有する極長鎖一価不飽和脂肪酸の基盤・応用研究 (研究課題/領域番号: 19H04055 )
化学療法による味覚障害発症の機序解明及び有効食品のスクリーニングシステムの開発 (研究課題/領域番号: 18K11075 )
細胞膜マイクロドメインを介する心筋保護作用に高血糖が及ぼす影響 (研究課題/領域番号: 16K10940 )
吸入麻酔薬の心筋保護作用における細胞膜マイクロドメインとオートファジーの役割（国際共同研究強化） (研究課題/領域番号: 15KK0344 )
重症患者におけるＢＩＡに基づいた栄養管理の有効性 (研究課題/領域番号: 15K16207 )
吸入麻酔薬の心筋保護作用における細胞膜マイクロドメインとオートファジーの役割 (研究課題/領域番号: 25462405 )
うま味成分による味覚受容体発現の調節―味覚異常患者用治療食への応用― (研究課題/領域番号: 24650489 )
栄養状態が生殖系に与える影響とそのメカニズムの解明 (研究課題/領域番号: 22700749 )
過栄養が引き起こすインスリン抵抗性分子メカニズムの解明 (研究課題/領域番号: 20890279 )
研究者番号（80510172）による検索

その他: 研究者総覧に該当データはありませんでした。

研究者総覧で最新データを確認する

2023年3月22日更新

専門分野・研究分野: 保健学 (Health Studies)
臨床栄養学 (Clinical Nutrition)
所属学会・所属協会: 日本病態栄養学会
日本静脈経腸栄養学会
日本小児栄養研究会
日本栄養改善学会
日本集中治療医学会
委員歴・役員歴: 日本病態栄養学会 (評議員 [2010年12月])
日本静脈経腸栄養学会 (学術評議員 [2003年4月])
日本小児栄養研究会 (運営委員 [2012年4月])
日本栄養改善学会 ( [2015年4月])
日本集中治療医学会 ( [2014年7月]) (日本集中治療医学会 [2008年4月])
受賞: 2012年9月, ネスレ科学財団論文賞 (ネスレ栄養科学財団)
2014年1月, (アメリカ集中治療医学会)
2014年1月, Annual GI/Nutrition Specialty Award (the Society of Critical Care Medicine)
2016年2月,
2016年3月, 医学部優秀教育賞 (徳島大学)
2016年3月, (徳島大学)
2017年10月, 徳島県科学技術大賞 (徳島県庁)
2018年10月,
活動: NHKカルチャーセンター (講師 [2010年9月〜2015年3月])
社会福祉法人あさがお会 (理事・評議員 [2015年7月〜2021年7月])
オープンキャンパス委員 (2019年4月)

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2023年3月19日更新

2023年3月18日更新

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Jグローバル最終確認日: 2023/3/18 01:29
氏名（漢字）: 堤理恵
氏名（フリガナ）: ツツミリエ
氏名（英字）: Rie Tsutsumi
所属機関: 徳島大学講師

リサーチマップ

researchmap最終確認日: 2023/3/19 01:42
氏名（漢字）: 堤理恵
氏名（フリガナ）: ツツミリエ
氏名（英字）: Rie Tsutsumi
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登録日時: 2013/5/14 13:38
更新日時: 2023/1/13 19:57
アバター画像URI: https://researchmap.jp/rie/avatar.jpeg
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所属ID: 0344000000
所属: 徳島大学
部署: 大学院医歯薬学研究部（医学系）
職名: 講師
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ＫＡＫＥＮで最新データを確認する

2023年3月18日更新

研究者番号: 80510172

所属（現在）: 2022/4/1 : 徳島大学, 大学院医歯薬学研究部(医学域), 講師

所属（過去の研究課題 情報に基づく）*注記: 2018/4/1 – 2022/4/1 : 徳島大学, 大学院医歯薬学研究部(医学域), 講師
2018/4/1 : 徳島大学, 大学院医歯薬学研究部(医学系), 講師
2016/4/1 – 2017/4/1 : 徳島大学, 大学院医歯薬学研究部(医学系), 助教
2015/4/1 : 徳島大学, 大学院医歯薬学研究部, 助教
2012/4/1 – 2014/4/1 : 徳島大学, ヘルスバイオサイエンス研究部, 助教
2010/4/1 – 2011/4/1 : 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教
2009/4/1 : 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 学術研究員
2008/4/1 : 武庫川女子大学短期大学部, 食生活学科, 講師

審査区分/研究分野

研究代表者

生物系 / 医歯薬学 / 内科系臨床医学 / 代謝学
総合・新領域系 / 総合領域 / 生活科学 / 食生活学
総合系 / 複合領域 / 生活科学 / 食生活学
小区分59040:栄養学および健康科学関連

研究代表者以外

生物系 / 医歯薬学 / 外科系臨床医学 / 麻酔科学
小区分59040:栄養学および健康科学関連
小区分55050:麻酔科学関連
小区分38050:食品科学関連

キーワード

研究代表者

mTOR / 栄養 / Rheb / 肝臓 / インスリン抵抗性 / たんぱく質合成 / トランスロケーション / Vps34 / アミノ酸 / ゴナドトロピン / kisspeptin / レプチン / ゴナドロピン / FSH / LH / ロイシン / 味覚 / 頭頸部癌 / 化学療法 / 味覚受容体 / 味覚異常 / がん / BIA / 重症患者 / 体組成 / 栄養管理 / ICU / 位相角 / 敗血症 / メタボローム解析 / タイチン / 筋萎縮 / T1R3 / メダカ / 味覚障害 / 食品 / スクリーニング / 小型魚類 / 胃切除 / 抗がん剤 / 食品成分

研究代表者以外

細胞膜マイクロドメイン / オートファジー / 吸入麻酔薬 / 心筋保護作用 / 虚血再灌流障害 / カベオラ / カベオリン / 虚血再灌流実験 / プレコンディショニング / 高血糖 / イソフルラン / 虚血再潅流障害 / 心肥大 / マイクロドメイン / 心筋肥大 / 一価不飽和脂肪酸 / 生活習慣病 / 抗動脈硬化作用 / 腸内細菌 / TMAO / GLP-1 / RCT / 動脈硬化 / 魚油 / 二重盲検試験 / トリメチルアミン-N-オキシド / グルカゴン様ペプチド-1 / SCFA / 血管内皮機能 / サルコペニア / サーチュイン / 香酸柑橘 / 脂肪細胞 / 分化抑制 / 阿波すず香

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2020年7月20日

PET-CTを用いたサルコペニアの画期的診断法の開発を目指した研究

阪上浩堤理恵黒田雅士大谷環樹親泊政一

2021年12月24日

栄養で、ヒトと科学、地域と科学をつなぐ

堤理恵

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堤 理恵

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堤理恵