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阿部考志

徳島大学

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2023年3月22日更新

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学位: 博士(医学)
職歴・経歴: 2012/4: 徳島大学特任助教, 病院 (-2014.3.)
2014/4: 徳島大学助教, 大学院ヘルスバイオサイエンス研究部 (-2015.3.)
2015/4: 徳島大学助教, 大学院医歯薬学研究部 (-2020.6.)

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2023年3月22日更新

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著書

原田雅史, 里見淳一郎, 藤田浩司, 山本信昭, 阿部考志 :
脳・脊髄の画像診断 ''鑑別診断力"を磨く厳選22題: 専門医試験の画像問題に自信がもてる!,
株式会社メディカ出版, 大阪, 2016年4月. 鹿草宏, 溝渕佳史, 中島公平, 藤田浩司, 阿部考志, 影治照喜, 里見淳一郎, 永廣信治, 山本伸昭 :
眼科内腫瘍性病変,
2015年7月. 武内俊明, 宮本亮介, 大崎裕亮, 阿部考志, 山本伸昭, 藤田浩司, 梶龍兒 :
中脳黒質におけるT1強調画像高信号,
株式会社メディカ出版, 大阪市淀川区宮原3-4-30, 2015年6月. 山本伸昭, 宮城愛, 藤田浩司, 阿部考志, 里見淳一郎, 梶龍兒 :
亜急性に経過した基底核・脳幹部病変,
2015年5月. 宮城愛, 山本伸昭, 藤田浩司, 阿部考志, 寺澤由佳, 梶龍兒 :
大脳半球に多発するT2*強調画像の点状低信号,
2015年2月. 山本伸昭, 宮城愛, 藤田浩司, 阿部考志, 梶龍兒 :
T1強調画像における基底核高信号,
2014年6月.

論文

Yuki Kanazawa, Masafumi Harada, Yo Taniguchi, Hiroaki Hayashi, Takashi Abe, Maki Ohtomo, Yuki Matsumoto, Masaharu Ono, Kosuke Ito, Yoshitaka Bito and Akihiro Haga :
Myelin-weighted imaging derived from quantitative parameter mapping,
European Journal of Radiology, Vol.156, No.110525, 1-9, 2022.

(要約): We developed a novel method which is applicable to visualize contrast according to myelin components in the human brain using relaxation time derived from quantitative parameter mapping magnetic resonance imaging (QPM-MRI). Using healthy volunteer data (n = 10), we verified that our method demonstrated that the myelin-weighted contrast increased proportionally by products R and R*, i.e., QPM-myelin-weighted image, in which modified T-weighted/T-weighted (Tw/Tw) ratio mapping method was applied. We compared measurement values in white matter (WM) and gray matter (GM) regions of the Tw/Tw ratio and R·R* product maps of healthy volunteers. Linear regression analysis between each value. Mann Whitney U test between WM and GM signals in each myelin map. In addition, Additionally, QPM-myelin-weighted image was applied to a 32-year-old female MS patient. Linear regression analysis showed a highly significant correlation between conventional Tw/Tw ratios and R·R* products derived from QPM (R = 0.73, P < 0.0001). Moreover, there is a significant difference between WM and GM structures in each myelin images (both, P < 0.0001). Additionally, in a clinical case, MS lesions enabled observation of not only MS plaques but also heterogeneous myelin signal loss associated with demyelination more clearly than Tw image and conventional Tw/Tw ratio image. Our myelin-weighted imaging technique using QPM may be useful for myelin visualization and is expected to become independent of measurement conditions due to having quantitative characteristics of QPM itself.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.ejrad.2022.110525
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36166986; ● Search Scopus @ Elsevier (PMID): 36166986; ● Search Scopus @ Elsevier (DOI): 10.1016/j.ejrad.2022.110525

(DOI: 10.1016/j.ejrad.2022.110525, PubMed: 36166986) Wataru Sako, Yuishin Izumi, Takashi Abe, Shotaro Haji, Nagahisa Murakami, Yusuke Osaki, Yuki Matsumoto, Masafumi Harada and Ryuji Kaji :
MR spectroscopy and imaging-derived measurements in the supplementary motor area for biomarkers of amyotrophic lateral sclerosis,
Neurological Sciences, Vol.42, No.10, 4257-4263, 2021.

(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s10072-021-05107-3
(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-85100872799

(DOI: 10.1007/s10072-021-05107-3, Elsevier: Scopus) Youichi Otomi, Nahomi Shono, Hajime Onishi, Ryota Mitsuhashi, Saya Matsuzaki, Yukiko Takaoka, Hideaki Enomoto, Yuko Sakamoto, Mihoko Sasahara, Takashi Abe, Takayoshi Shinya, Hideki Otsuka and Masafumi Harada :
A reduced physiological 18 F-fluorodeoxyglucose uptake in the brain and liver caused by malignant lymphoma being deprived of the tracer,
The Journal of Medical Investigation : JMI, Vol.68, No.1. 2, 181-185, 2021.

(要約): Purpose : To investigate whether or not the physiological brain and liver FDG uptake are decreased in patients with highly accelerated glycolysis lesions. Methods : We retrospectively analyzed 51 patients with malignant lymphoma. We compared the FDG uptake in the brain and liver of the patients with that in a control group. In 24 patients with a complete response (CR) or partial response (PR) to treatment, we compared the brain and liver uptake before and after treatment. Results : The maximum standardized uptake value (SUVmax) and total glycolytic volume (TGV) of the brain as well as the SUVmax and mean standardized uptake value (SUVmean) of the liver in malignant lymphoma patients were 13.1 ± 2.3, 7386.3 ± 1918.4, 3.2 ± 0.5, and 2.3 ± 0.4, respectively ; in the control group, these values were 14.9 ± 2.4, 8566.2 ± 1659.5, 3.4 ± 0.4, and 2.5 ± 0.3, respectively. The SUVmax and TGV of the brain and the SUVmean of the liver in malignant lymphoma patients were significantly lower than the control group. The SUVmax and TGV of the brain after treatment were significantly higher than before treatment. Both the SUVmax and SUVmean of liver after treatment were higher than before treatment, but not significant. Conclusion : A decreased physiological brain and liver FDG uptake is caused by highly accelerated lesion glycolysis. J. Med. Invest. 68 : 181-185, February, 2021.
(キーワード): Brain / Fluorodeoxyglucose F18 / Humans / Liver / Lymphoma / Positron Emission Tomography Computed Tomography / Radiopharmaceuticals / Retrospective Studies
(徳島大学機関リポジトリ): ● Metadata: 116011
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.68.181
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33994467; ● CiNii @ 国立情報学研究所 (CRID): 1390006585528207872; ● Search Scopus @ Elsevier (PMID): 33994467; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.68.181

(徳島大学機関リポジトリ: 116011, DOI: 10.2152/jmi.68.181, PubMed: 33994467, CiNii: 1390006585528207872) Maki Ohtomo, Masafumi Harada, Takashi Abe, Yuki Matsumoto, Yumi Abe, Yuki Kanazawa, Mitsuharu Miyoshi, Hiroyuki Kabasawa and Yoshitake Takahashi :
Reproducibility and Variability of Quantitative Cerebral Blood Flow Measured by Multi-delay 3D Arterial Spin Labeling According to Sex and Menstrual Cycle,
The Journal of Medical Investigation : JMI, Vol.67, No.3.4, 321-327, 2020.

(要約): Purpose : To determine the reproducibility of corrected quantitative cerebral blood flow (qCBF) through measurement of transit flow time using multi-delay three-dimensional pseudo-continuous arterial spin labeling (pCASL) in healthy men and women and to evaluate the differences in qCBF between not only men and women, but also the follicular and luteal phases of the women's menstrual cycle. Methods : The participants were 16 healthy volunteers (8 men and 8 women ; mean age, 25.3 years). Two MRI were conducted for all participants ; female participants were conducted in the follicular and luteal phases. The reproducibility of qCBF values was evaluated by the intraclass correlation coefficient (ICC) and differences between the two groups were estimated by voxel-based morphometry (VBM) analysis. Results : The qCBF values were lower in men than in women, and those in females were significantly different between the follicular and luteal phases (P < 0.05). In VBM analysis, the qCBF values of the lower frontal lobes were significantly higher in women than in men (P < 0.05). The qCBF values of the frontal pole were significantly higher in the follicular phase than in the luteal phase (P < 0.01). Conclusion : Multi-delay pCASL can reveal physiological and sex differences in cerebral perfusion. J. Med. Invest. 67 : 321-327, August, 2020.
(キーワード): 脳神経画像 / 動脈スピン標識法 / 脳血流量 (cerebral blood flow) / 三次元定位ROIテンプレート / 男女差
(徳島大学機関リポジトリ): ● Metadata: 115293
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.67.321
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33148909; ● Search Scopus @ Elsevier (PMID): 33148909; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.67.321

(徳島大学機関リポジトリ: 115293, DOI: 10.2152/jmi.67.321, PubMed: 33148909) Yuki Kanazawa, Masafumi Harada, Mitsuharu Miyoshi, Takashi Abe, Yuki Matsumoto and Yasushi Takagi :
Characterization of Brain Tumors using Amide Proton and Nuclear Overhauser Effect at 3 Tesla MR Scanner,
Proceedings of the 28th Virtual Conference of ISMRM, No.1697, 2020. Yuki Kanazawa, Masafumi Harada, Tosiaki Miyati, Takashi Abe, Mitsuharu Miyoshi, Yuki Matsumoto, Hiroaki Hayashi, Yasuhisa Kanematsu and Yasushi Takagi :
Chemical Exchange Saturation Transfer Imaging for Atherosclerotic Plaques,
Proceedings of 28th Virtual Meeting of ISMRM, No.2128, 2020. Yugo Wada, Yuki Kanazawa, Masafumi Harada, Naoki Maeda, Yuki Matsumoto, Takashi Abe, Hiroaki Hayashi, Mitsuharu Miyoshi and Carl Michael :
Multi-components analysis of brain using ultrashort echo time magnetic resonance imaging,
European Congress of Radiology (EPOS), No.C-08766, 2020.

(出版サイトへのリンク): ● Publication site (DOI): 10.26044/ecr2020/C-08766
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.26044/ecr2020/C-08766

(DOI: 10.26044/ecr2020/C-08766) Naoki Maeda, Yuki Kanazawa, Masafumi Harada, Yo Taniguchi, Yuki Matsumoto, Takashi Abe, Hiroaki Hayashi, Masaharu Ono and Yoshitaka Bito :
Multicomponent T1 Relaxometry Analysis using Quantitative Parameter Mapping Magnetic Resonance Imaging,
European Congress of Radiology (EPOS), No.C-8678, 2020.

(出版サイトへのリンク): ● Publication site (DOI): 10.26044/ecr2020/C-08767
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.26044/ecr2020/C-08767

(DOI: 10.26044/ecr2020/C-08767) Kenya Kusunose, Takashi Abe, Akihiro Haga, Daiju Fukuda, Hirotsugu Yamada, Masafumi Harada and Masataka Sata :
A Deep Learning Approach for Assessment of Regional Wall Motion Abnormality From Echocardiographic Images,
JACC. Cardiovascular Imaging, Vol.13, No.2, 374-381, 2020.

(要約): This study investigated whether a deep convolutional neural network (DCNN) could provide improved detection of regional wall motion abnormalities (RWMAs) and differentiate among groups of coronary infarction territories from conventional 2-dimensional echocardiographic images compared with that of cardiologists, sonographers, and resident readers. An effective intervention for reduction of misreading of RWMAs is needed. The hypothesis was that a DCNN trained using echocardiographic images would provide improved detection of RWMAs in the clinical setting. A total of 300 patients with a history of myocardial infarction were enrolled. From this cohort, 3 groups of 100 patients each had infarctions of the left anterior descending (LAD) artery, the left circumflex (LCX) branch, and the right coronary artery (RCA). A total of 100 age-matched control patients with normal wall motion were selected from a database. Each case contained cardiac ultrasonographs from short-axis views at end-diastolic, mid-systolic, and end-systolic phases. After the DCNN underwent 100 steps of training, diagnostic accuracies were calculated from the test set. Independently, 10 versions of the same model were trained, and ensemble predictions were performed using those versions. For detection of the presence of WMAs, the area under the receiver-operating characteristic curve (AUC) produced by the deep learning algorithm was similar to that produced by the cardiologists and sonographer readers (0.99 vs. 0.98, respectively; p = 0.15) and significantly higher than the AUC result of the resident readers (0.99 vs. 0.90, respectively; p = 0.002). For detection of territories of WMAs, the AUC by the deep learning algorithm was similar to the AUC by the cardiologist and sonographer readers (0.97 vs. 0.95, respectively; p = 0.61) and significantly higher than the AUC by resident readers (0.97 vs. 0.83, respectively; p = 0.003). From a validation group at an independent site (n = 40), the AUC by the deep learning algorithm was 0.90. The present results support the possibility of using DCNN for automated diagnosis of RWMAs in the field of echocardiography.
(徳島大学機関リポジトリ): ● Metadata: 114196
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jcmg.2019.02.024
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31103590; ● Summary page in Scopus @ Elsevier: 2-s2.0-85070068493

(徳島大学機関リポジトリ: 114196, DOI: 10.1016/j.jcmg.2019.02.024, PubMed: 31103590, Elsevier: Scopus) Kenya Kusunose, Akihiro Haga, Natsumi Yamaguchi, Takashi Abe, Daiju Fukuda, Hirotsugu Yamada, Masafumi Harada and Masataka Sata :
Deep Learning for Assessment of Left Ventricular Ejection Fraction from Echocardiographic Images,
Journal of the American Society of Echocardiography, Vol.33, No.5, 632-635, 2020.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.echo.2020.01.009
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32111541; ● Summary page in Scopus @ Elsevier: 2-s2.0-85080044447

(DOI: 10.1016/j.echo.2020.01.009, PubMed: 32111541, Elsevier: Scopus) Kenya Kusunose, Akihiro Haga, Takashi Abe and Masataka Sata :
Utilization of Artificial Intelligence in Echocardiography,
Circulation Journal, Vol.83, No.8, 1623-1629, 2019.

(要約): Echocardiography has a central role in the diagnosis and management of cardiovascular disease. Precise and reliable echocardiographic assessment is required for clinical decision-making. Even if the development of new technologies (3-dimentional echocardiography, speckle-tracking, semi-automated analysis, etc.), the final decision on analysis is strongly dependent on operator experience. Diagnostic errors are a major unresolved problem. Moreover, not only can cardiologists differ from one another in image interpretation, but also the same observer may come to different findings when a reading is repeated. Daily high workloads in clinical practice may lead to this error, and all cardiologists require precise perception in this field. Artificial intelligence (AI) has the potential to improve analysis and interpretation of medical images to a new stage compared with previous algorithms. From our comprehensive review, we believe AI has the potential to improve accuracy of diagnosis, clinical management, and patient care. Although there are several concerns about the required large dataset and "black box" algorithm, AI can provide satisfactory results in this field. In the future, it will be necessary for cardiologists to adapt their daily practice to incorporate AI in this new stage of echocardiography.
(徳島大学機関リポジトリ): ● Metadata: 114194
(出版サイトへのリンク): ● Publication site (DOI): 10.1253/circj.CJ-19-0420
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31257314; ● Summary page in Scopus @ Elsevier: 2-s2.0-85070102118

(徳島大学機関リポジトリ: 114194, DOI: 10.1253/circj.CJ-19-0420, PubMed: 31257314, Elsevier: Scopus) Wataru Sako, Takashi Abe, Shotaroh Haji, Nagahisa Murakami, Yusuke Osaki, Yuishin Izumi, Masafumi Harada and Ryuji Kaji :
A method for differential diagnosis of parkinsonian syndromes,
Acta Neurologica Scandinavica, Vol.140, No.3, 229-235, 2019.

(要約): Neurological findings are important for the differential diagnosis of Parkinson's disease (PD), multiple system atrophy with predominant parkinsonian features (MSA-P), and progressive supranuclear palsy (PSP). There is currently no fast and reliable method to distinguish these patients. To address this, we propose a novel approach to measure midbrain and pons size using a longitudinal "one line" method from the mid-sagittal view. Structural images were acquired from 101 subjects who underwent 3.0 T MRI (20 controls, 44 PD, 20 MSA, 12 PSP, and 5 corticobasal syndrome). We measured the middle cerebellar peduncle (MCP), superior cerebellar peduncle (SCP), midbrain, and pons. Brainstem size was measured by area or length of the longitudinal axis, which we named the "one line" method. We conducted intraclass correlation coefficients to assess the extent of agreement and consistency among raters, and receiver operating characteristic curves were used to determine diagnostic accuracy. Intraclass correlation coefficients (ICC) of MCP width were excellent in sagittal and axial sections while those of SCP width were moderate. There were also excellent ICCs between raters for "one line" method of the midbrain and pons, while areas showed good ICCs. "One line" method and area of the midbrain were better than SCP width for the differential diagnosis of PSP from MSA-P and PD. In contrast, there was no clearly superior measurement for differentially diagnosing MSA-P. The "one line" method was comparable with area for inter-rater agreement and diagnostic accuracy even though this was a simple and fast way.
(キーワード): Aged / Diagnosis, Differential / Female / Humans / Magnetic Resonance Imaging / Male / Mesencephalon / Middle Aged / Multiple System Atrophy / Parkinsonian Disorders / Pons / Supranuclear Palsy, Progressive
(出版サイトへのリンク): ● Publication site (DOI): 10.1111/ane.13136
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31225648; ● Summary page in Scopus @ Elsevier: 2-s2.0-85067842485

(DOI: 10.1111/ane.13136, PubMed: 31225648, Elsevier: Scopus) Yuki Kanazawa, Chiba Daiki, Masafumi Harada, Miyati Tosiaki, Miyoshi Mitsuharu, Hiroaki Hayashi, Yuki Matsumoto, Takashi Abe and Akihiro Haga :
Thermal sensitive pH imaging using CEST,
Proceedings of the 27th Annual Meeting of ISMRM, No.3991, 2019. Yuki Kanazawa, Masafumi Harada, Taniguchi Yo, Hiroaki Hayashi, Takashi Abe, Maki Ohtomo, Yuki Matsumoto, Ono Masafumi, Bito Yoshitaka and Akihiro Haga :
Myelin imaging derived from quantitative parameter mapping,
Proceedings of the 27th Annual Meeting of ISMRM, No.3313, 2019. Wataru Sako, Takashi Abe, Yuishin Izumi, Masafumi Harada and Ryuji Kaji :
Deterministic-tractography-based approach for diagnosis and disease monitoring of amyotrophic lateral sclerosis,
Clinical Neurology and Neurosurgery, Vol.181, 73-75, 2019.

(要約): Upper and lower motor neuron signs are required for the diagnosis of amyotrophic lateral sclerosis. The detection of upper motor neuron signs is key for the diagnosis, as quite a few patients with amyotrophic lateral sclerosis lack upper motor neuron signs during the course of disease. This study sought to investigate whether deterministic tractography of the corticospinal tract, reflecting upper motor neuron signs, could be a surrogate biomarker for amyotrophic lateral sclerosis. Fifteen patients with amyotrophic lateral sclerosis and ten controls underwent imaging on a 3.0 T MRI. The corticospinal tract was reconstructed using deterministic tractography, and the track number was calculated. We analyzed the differences between the groups and the relationship between the track number and disease severity, disease duration, progression rate or upper motor neuron signs. A reduction in the track number of the corticospinal tract was found in amyotrophic lateral sclerosis compared with controls (Student's t test, P = 0.008). The sensitivity and specificity were 0.67 and 0.9, respectively. The track number correlated with disease severity alone (r = 0.71, P = 0.003), and significantly associated with upper motor neuron signs (P = 0.004). These findings suggest that the deterministic-tractography-based approach is a potential biomarker for the diagnosis and disease monitoring of amyotrophic lateral sclerosis.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.clineuro.2019.04.015
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31009854; ● Summary page in Scopus @ Elsevier: 2-s2.0-85064459749

(DOI: 10.1016/j.clineuro.2019.04.015, PubMed: 31009854, Elsevier: Scopus) Takashi Abe, Yuki Matsumoto, Yuki Kanazawa, Yoichi Otomi, Maki Otomo, Moriaki Yamanaka, Mihoko Kondo, Saya Matsuzaki, Ariunbold Gankhuyag, Enkhamgalan Dolgorsuren, Oyundari Gonchigsuren and Masafumi Harada :
Comparing neural networks for synthesizing FLAIR images from T1WI and T2WI,
Proceedings of the 27th Annual Meeting of ISMRM, No.240, 2019. Wataru Sako, Takashi Abe, T Furukawa, R Oki, Shotaroh Haji, Nagahisa Murakami, Yuishin Izumi, Masafumi Harada and Ryuji Kaji :
Differences in the intra-cerebellar connections and graph theoretical measures between Parkinson's disease and multiple system atrophy,
Journal of the Neurological Sciences, Vol.400, 129-134, 2019.

(要約): Parkinson's disease (PD) does not present with motor symptoms until dopaminergic neuronal loss exceeds 50%. This might indicate that a network-level compensatory mechanism involving surviving regions in PD acts to reduce brain abnormalities. In contrast, there is no evidence of a compensatory mechanism in multiple system atrophy (MSA). We hypothesized that a comparison of these two diseases would help to identify compensatory effects in PD. We recruited 23 patients with PD, 11 patients with MSA, and 11 controls that showed an aging brain but no neurological deficits. All subjects underwent resting state functional magnetic resonance imaging (fMRI). Regions of interest were defined according to the motor network related to the basal ganglia and cerebellum. Network-level analyses were performed. Network-based statistical analyses revealed that functional connectivity in PD brains was reduced between cerebellar lobules IX on both sides and vermis X, as compared with MSA brains. Transitivity was reduced in MSA as compared with controls. We demonstrated that a part of the intra-cerebellar connectivity was reduced in PD, and that network segregation was reduced in MSA. However, there was no evidence of compensatory effects in PD.
(キーワード): Aged / Aged, 80 and over / Cerebellum / Female / Humans / Magnetic Resonance Imaging / Male / Middle Aged / Multiple System Atrophy / Nerve Net / Parkinson Disease
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jns.2019.03.022
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30928779; ● Summary page in Scopus @ Elsevier: 2-s2.0-85063409926

(DOI: 10.1016/j.jns.2019.03.022, PubMed: 30928779, Elsevier: Scopus) Youichi Otomi, Hideki Otsuka, Kaori Terazawa, Moriaki Yamanaka, Yuki Obama, Maki Arase, Maki Otomo, Saho Irahara, Michiko Kubo, Naoto Uyama, Takashi Abe and Masafumi Harada :
The diagnostic ability of SPECT/CT fusion imaging for gastrointestinal bleeding: a retrospective study.,
BMC Gastroenterology, Vol.18, No.1, 183, 2018.

(要約): Blood loss from the gastrointestinal tract can be an acute and life-threatening event. For the treatment of gastrointestinal bleeding, it is important to accurately detect gastrointestinal bleeding and to localize the sites of bleeding. The purpose of this study was to retrospectively assess the capabilities of SPECT/CT in the diagnosis of gastrointestinal bleeding by a comparison with planar imaging alone as well as planar and SPECT. We conducted a retrospective analysis of 20 patients (21 examinations) who underwent gastrointestinal bleeding scintigraphy in the past 7ears and in whom the bleeding site was identified by endoscopy or capsule endoscopy, or in whom no evidence of gastrointestinal bleeding was identified during the clinical course. Five patients (5 examinations) were diagnosed by planar imaging (planar group). Eight patients (9 examinations) were diagnosed by planar imaging and SPECT (planar + SPECT group). Seven patients (7 examinations) were diagnosed by planar imaging and SPECT/CT (planar + SPECT/CT group). We calculated the diagnostic ability of each method in detecting the presence of bleeding, as well as the ability of each method to identify the sites of bleeding. The sensitivity, specificity, and accuracy of the methods were compared. The diagnostic ability of the three imaging methods in detecting the presence of gastrointestinal bleeding was as follows. Planar imaging showed 100% sensitivity (3/3), 100% specificity (2/2), and 100% accuracy (5/5). Planar + SPECT imaging showed 85.7% sensitivity (6/7), 100% specificity (2/2), and 88.9% accuracy (8/9). Planar + SPECT/CT imaging showed 100% sensitivity (6/6), 100% specificity (1/1), and 100% accuracy (7/7). The diagnostic ability of the three modalities in detecting the site of bleeding was as follows: planar, 33.3% (1/3); planar + SPECT, 71.4% (5/7); and planar + SPECT/CT, 100% (6/6). All 3 imaging methods showed good accuracy in detecting the presence of gastrointestinal bleeding. The addition of SPECT or SPECT/CT made the anatomical position of the uptake clear and contributed to the localization of the site of gastrointestinal bleeding. Planar + SPECT/CT imaging therefore showed the highest diagnostic ability for detecting the site of gastrointestinal bleeding.
(キーワード): Adult / Aged / Female / Gastrointestinal Hemorrhage / Humans / Male / Middle Aged / Radiopharmaceuticals / Retrospective Studies / Sensitivity and Specificity / Single Photon Emission Computed Tomography Computed Tomography / Technetium Tc 99m Aggregated Albumin / Technetium Tc 99m Pentetate
(徳島大学機関リポジトリ): ● Metadata: 114350
(出版サイトへのリンク): ● Publication site (DOI): 10.1186/s12876-018-0915-7
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30526506; ● Search Scopus @ Elsevier (PMID): 30526506; ● Search Scopus @ Elsevier (DOI): 10.1186/s12876-018-0915-7

(徳島大学機関リポジトリ: 114350, DOI: 10.1186/s12876-018-0915-7, PubMed: 30526506) Khashbat Delgerdalai, Masafumi Harada, Takashi Abe, Ganbold Mungunbagana, Seiji Iwamoto, Naoto Uyama, Saho Irahara, Youichi Otomi, Teruyoshi Kageji and Shinji Nagahiro :
Diagnostic Performance of Arterial Spin Labeling for Grading Nonenhancing Astrocytic Tumors,
Magnetic Resonance in Medical Sciences, Vol.17, No.4, 277-282, 2018.

(徳島大学機関リポジトリ): ● Metadata: 116461
(出版サイトへのリンク): ● Publication site (DOI): 10.2463/mrms.mp.2017-0065
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29238007; ● Summary page in Scopus @ Elsevier: 2-s2.0-85055173772

(徳島大学機関リポジトリ: 116461, DOI: 10.2463/mrms.mp.2017-0065, PubMed: 29238007, Elsevier: Scopus) Shinji Nagahiro, Yoshiteru Tada, Junichiro Satomi, Tomoya Kinouchi, Kazuyuki Kuwayama, Kenji Yagi, Kohhei Nakajima, Nobuhisa Matsushita, Takeshi Miyamoto, Tadashi Yamaguchi, Kenji Shimada, Masaaki Korai, Hideo Mure, Y Okayama, Takashi Abe, Masafumi Harada, Keiko T. Kitazato and Yasuhisa Kanematsu :
Treatment of Unruptured Cerebral Aneurysms with the Mineralocorticoid Receptor Blocker Eplerenone-Pilot Study.,
Journal of Stroke & Cerebrovascular Diseases, Vol.27, No.8, 2134-2140, 2018.

(要約): Currently there are no pharmacological therapies for patients with unruptured cerebral aneurysms. Elsewhere we showed that the mineralocorticoid receptor antagonist eplerenone prevented the formation of cerebral aneurysms in our ovariectomized hypertensive aneurysm rat model. The current pilot study evaluated whether it can be used to prevent the growth and rupture of cerebral aneurysms in hypertensive patients. Between August 2011 and May 2014, we enrolled 82 patients with 90 aneurysms in an open-label uncontrolled clinical trial. All provided prior informed consent for inclusion in this study, and all were treated with eplerenone (25-100 mg/d). The primary end points of our study were the rupture and enlargement of the cerebral aneurysms. Of the 82 patients, 80 (88 unruptured aneurysms) were followed for a mean of 21.3 months (153.4 aneurysm-years); 12 patients (15.0%) permanently discontinued taking the drug. One month after the start of eplerenone administration and throughout the follow-up period, eplerenone kept the blood pressure within the normal range. Most notably, no aneurysms smaller than 9 mm ruptured or enlarged. However, of 2 large thrombosed aneurysms, 1 enlarged and the other ruptured. The overall annual rupture rate was .65%; it was 13.16% for aneurysms larger than 10 mm; the overall annual rate for reaching the primary end points was 1.30%. Our observations suggest that eplerenone may help to prevent the growth and rupture of unruptured cerebral aneurysms smaller than 9 mm. To assess its potential long-term clinical benefits, large clinical trials are needed.
(キーワード): Aged / Aneurysm, Ruptured / 脳 (brain) / Disease Progression / 女性 (female) / Follow-Up Studies / Humans / Intracranial Aneurysm / 男性 (male) / Mineralocorticoid Receptor Antagonists / Neuroprotective Agents / Pilot Projects / Spironolactone / Treatment Outcome
(徳島大学機関リポジトリ): ● Metadata: 115570
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jstrokecerebrovasdis.2018.03.008
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29622372; ● Summary page in Scopus @ Elsevier: 2-s2.0-85049537109

(徳島大学機関リポジトリ: 115570, DOI: 10.1016/j.jstrokecerebrovasdis.2018.03.008, PubMed: 29622372, Elsevier: Scopus) Koji Fujita, Yusuke Osaki, Ryosuke Miyamoto, Shimatani Yoshimitsu, Takashi Abe and Shimatani Yoshimitsu :
Neurologic attack and dynamic perfusion abnormality in neuronal intranuclear inclusion disease,
Neurology. Clinical Practice, Vol.7, No.6, e39-e42, 2017.

(出版サイトへのリンク): ● Publication site (DOI): 10.1212/CPJ.0000000000000389
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29431160; ● Search Scopus @ Elsevier (PMID): 29431160; ● Search Scopus @ Elsevier (DOI): 10.1212/CPJ.0000000000000389

(DOI: 10.1212/CPJ.0000000000000389, PubMed: 29431160) Shu Sogabe, Junichiro Satomi, Yoshiteru Tada, Yasuhisa Kanematsu, Kazuyuki Kuwayama, Kenji Yagi, Shotaroh Yoshioka, Yoshifumi Mizobuchi, Hideo Mure, Izumi Yamaguchi, Takashi Abe, Nobuaki Yamamoto, Keiko Kitazato, Ryuji Kaji, Masafumi Harada and Shinji Nagahiro :
Intra-arterial high signals on arterial spin labeling perfusion images predict the occluded internal carotid artery segment,
Neuroradiology, Vol.59, No.6, 587-595, 2017.

(要約): Arterial spin labeling (ASL) involves perfusion imaging using the inverted magnetization of arterial water. If the arterial arrival times are longer than the post-labeling delay, labeled spins are visible on ASL images as bright, high intra-arterial signals (IASs); such signals were found within occluded vessels of patients with acute ischemic stroke. The identification of the occluded segment in the internal carotid artery (ICA) is crucial for endovascular treatment. We tested our hypothesis that high IASs on ASL images can predict the occluded segment. Our study included 13 patients with acute ICA occlusion who had undergone angiographic and ASL studies within 48 h of onset. We retrospectively identified the high IAS on ASL images and angiograms and recorded the occluded segment and the number of high IAS-positive slices on ASL images. The ICA segments were classified as cervical (C1), petrous (C2), cavernous (C3), and supraclinoid (C4). Of seven patients with intracranial ICA occlusion, five demonstrated high IASs at C1-C2, suggesting that high IASs could identify stagnant flow proximal to the occluded segment. Among six patients with extracranial ICA occlusion, five presented with high IASs at C3-C4, suggesting that signals could identify the collateral flow via the ophthalmic artery. None had high IASs at C1-C2. The mean number of high IAS-positive slices was significantly higher in patients with intra- than extracranial ICA occlusion. High IASs on ASL images can identify slow stagnant and collateral flow through the ophthalmic artery in patients with acute ICA occlusion and help to predict the occlusion site.
(徳島大学機関リポジトリ): ● Metadata: 111444
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s00234-017-1828-9
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28397019; ● Search Scopus @ Elsevier (PMID): 28397019; ● Search Scopus @ Elsevier (DOI): 10.1007/s00234-017-1828-9

(徳島大学機関リポジトリ: 111444, DOI: 10.1007/s00234-017-1828-9, PubMed: 28397019) Wataru Sako, Takashi Abe, Yuishin Izumi, Hiroki Yamazaki, Naoko Matsui, Masafumi Harada and Ryuji Kaji :
Spontaneous brain activity in the sensorimotor cortex in amyotrophic lateral sclerosis can be negatively regulated by corticospinal fiber integrity.,
Neurological Sciences, Vol.38, No.5, 755-760, 2017.

(要約): Previous studies failed to detect reduced value of the amplitude of low frequency fluctuation (ALFF) derived from resting state functional magnetic resonance imaging in the primary motor cortex in amyotrophic lateral sclerosis (ALS) though primary motor cortex was mainly affected with ALS. We aimed to investigate the cause of masking the abnormality in the primary motor cortex in ALS and usefulness of ALFF for differential diagnosis among diseases showing muscle weakness. We enrolled ten patients with ALS and eleven disease controls showing muscle weakness. Voxel-wise analysis revealed that significant reduction of ALFF value was present in the right sensorimotor cortex in ALS. There was a significant negative correlation between ALFF value in the right sensorimotor cortex and fractional anisotropy (FA) value in the posterior limbs of the internal capsule (PLIC). For a diagnostic tool, the area under receiver operating characteristic curve improved if the ALS patients with disease duration >1 year were excluded. The present findings raised the possibility of usefulness of ALFF value in the sensorimotor cortex for differential diagnosis of ALS, and supported the notion that adjustment for FA value in the PLIC could improve accuracy.
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s10072-017-2831-y
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28150100; ● Search Scopus @ Elsevier (PMID): 28150100; ● Search Scopus @ Elsevier (DOI): 10.1007/s10072-017-2831-y

(DOI: 10.1007/s10072-017-2831-y, PubMed: 28150100) Mungunbagana Ganbold, Masafumi Harada, Delgerdalai Khashbat, Takashi Abe, Teruyoshi Kageji and Shinji Nagahiro :
Differences In High-Intensity Signal Volume Between Arterial Spin Labeling And Contrast-Enhanced T1-Weighted Imaging May Be Useful For Differentiating Glioblastoma From Brain Metastasis,
The Journal of Medical Investigation : JMI, Vol.64, No.1.2, 58-63, 2017.

(要約): To determine whether differences in tumor volume between arterial spin labeling (ASL) and contrast-enhanced T1-weighted MR images (CE+T1WI) can help differentiate glioblastoma (GBM) from brain metastasis. Patients with a diagnosis of GBM (n=25) or brain metastasis (n=13) were examined by both conventional and ASL MR imaging. Volumes of interest with high signal intensity on ASL and CE+T1WI were defined using three dimensional analysis software. Tumor volume difference (ASL-CE) and tumor volume ratio (ASL/CE) were obtained. Absolute maximal tumor blood flow (TBF) and TBF ratio (normalized to white matter) were also measured. The Mann-Whitney U test and receiver operating characteristic curve analysis were performed to compare measurements between the tumor groups. Both tumor volume difference and tumor volume ratio were significantly higher in GBM than in metastasis. Both TBF and TBF ratio were higher for GBM than for metastasis, but the differences were not significant. The difference in tumor volume as measured by ASL high signal intensity and CE+T1WI might be useful for differentiating GBM from metastasis, whereas ASL-derived TBF is insufficient. J. Med. Invest. 64: 58-63, February, 2017.
(徳島大学機関リポジトリ): ● Metadata: 111082
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.64.58
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28373629; ● Search Scopus @ Elsevier (PMID): 28373629; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.64.58

(徳島大学機関リポジトリ: 111082, DOI: 10.2152/jmi.64.58, PubMed: 28373629) Takashi Abe, Toshitaka Kawarai, Koji Fujita, Wataru Sako, Yuka Terasawa, Tsuyoshi Matsuda, Waka Sakai, Ai Tsukamoto-Miyashiro, Naoko Matsui, Yuishin Izumi, Ryuji Kaji and Masafumi Harada :
MR Spectroscopy in Patients with Hereditary Diffuse Leukoencephalopathy with Spheroids and Asymptomatic Carriers of Colony-stimulating Factor 1 Receptor Mutation.,
Magnetic Resonance in Medical Sciences, Vol.16, No.4, 297-303, 2016.

(要約): Hereditary diffuse leukoencephalopathy with spheroids (HDLS) is a rare neurodegenerative disorder with various clinical presentations. Mutation of the colony-stimulating factor 1 receptor (CSF1R) gene is considered to be a cause of this autosomal dominant disorder. The purpose of this study was to report magnetic resonance spectroscopy (MRS) findings in patients with HDLS and asymptomatic carriers and to clarify the use of MRS in this disease. In this retrospective, institutional review board-approved study, we included four consecutive patients, genetically diagnosed with HDLS, and two asymptomatic carriers after acquiring informed consent. We performed single-voxel MRS of the left centrum semiovale on a 3-T clinical scanner. We also included a sex-matched normal dataset. We quantified N-acetylaspartate (NAA), creatine, choline-containing compounds (Cho), glutamine, glutamate (Glu), myo-inositol (Ins), glutathione, lactate (Lac), and gamma-amino butyric acid using LCModel. We performed statistical analysis, and P value <0.05 was considered significant. In HDLS cases, MRS revealed decreased NAA and Glu concentrations, which probably reflected neuronal damage and/or loss, and a subsequent reduction of neurotransmitters. A patient with HDLS also had increased Cho and Ins concentrations, indicating gliosis, and increased Cho concentration was also observed in an asymptomatic carrier. This suggests that metabolic changes had already occurred in an asymptomatic state. We demonstrated changes in metabolite concentrations not only in patients with HDLS but also in asymptomatic CSF1R mutation carriers. Our study indicates that MRS is a potentially useful tool for the analysis of metabolic and pathophysiological findings of HDLS, even during the early stages of disease.
(徳島大学機関リポジトリ): ● Metadata: 116229
(出版サイトへのリンク): ● Publication site (DOI): 10.2463/mrms.mp.2016-0016
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28025469; ● Summary page in Scopus @ Elsevier: 2-s2.0-85031294587

(徳島大学機関リポジトリ: 116229, DOI: 10.2463/mrms.mp.2016-0016, PubMed: 28025469, Elsevier: Scopus) Delgerdalai Khashbat, Takashi Abe, Mungunbagana Ganbold, Seiji Iwamoto, Naoto Uyama, Saho Irahara, Youichi Otomi, Masafumi Harada, Teruyoshi Kageji and Shinji Nagahiro :
Correlation of 3D Arterial Spin Labeling and Multi-Parametric Dynamic Susceptibility Contrast Perfusion MRI in Brain Tumors.,
The Journal of Medical Investigation : JMI, Vol.63, No.3-4, 175-181, 2016.

(要約): Arterial spin labeling (ASL) is an alternative method to Dynamic susceptibility contrast (DSC) perfusion MRI for brain tumors. However, ASL cerebral blood flow (CBF) can be easily affected by transit time. DSC MRI derived time to maximum of the residue function (Tmax) is possible to assess the transit time on ASL. Thirty patients with brain tumors were studied using ASL and DSC MRI. The relative cerebral blood flow (rCBF), relative cerebral blood volume (rCBV), Tmax, and mean transit time (MTT) were obtained from DSC MRI. The ratios of the parameters were analyzed. ASL CBF ratio correlated with the DSC rCBF ratio (r=0.78, p<0.001) and rCBV ratio (r=0.74, p<0.001). There was a moderate correlation between ASL CBF ratio and Tmax ratio (r=-0.43, p<0.05) in brain tumors. ASL CBF strongly correlated with DSC rCBF and rCBV. In addition, a negative correlation was found between ASL CBF and Tmax in brain tumors, indicating that these parameters would be affected by transit time. This may explain why ASL CBF is different from DSC rCBF and rCBV. The decreased DSC Tmax value may suggest high vascularity in a tumor. J. Med. Invest. 63: 175-181, August, 2016.
(キーワード): Adult / Aged / Brain Neoplasms / Cerebrovascular Circulation / Contrast Media / Female / Humans / 磁気共鳴映像法 (magnetic resonance imaging) / Male / Middle Aged / Perfusion Imaging / Spin Labels
(徳島大学機関リポジトリ): ● Metadata: 111177
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.63.175
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27644554; ● Summary page in Scopus @ Elsevier: 2-s2.0-84987858651

(徳島大学機関リポジトリ: 111177, DOI: 10.2152/jmi.63.175, PubMed: 27644554, Elsevier: Scopus) Wataru Sako, Takashi Abe, Nagahisa Murakami, Yoshimichi Miyazaki, Yuishin Izumi, Masafumi Harada and Ryuji Kaji :
Imaging-based differential diagnosis between multiple system atrophy and Parkinson's disease.,
Journal of the Neurological Sciences, Vol.368, 104-108, 2016.

(要約): There are many tools for differentiating between multiple system atrophy with predominant parkinsonian features (MSA-P) and Parkinson's disease (PD). These include middle cerebellar peduncle (MCP) width, apparent diffusion coefficient (ADC) value of the putamen and cerebellum, and (123)I-metaiodobenzylguanidine (MIBG) myocardial scintigraphy images. We aimed to directly compare the above-mentioned methods, and to determine the optimal tool for differential diagnosis. Eleven patients with MSA-P and 36 patients with PD were enrolled. Of these, 7 patients with MSA-P and 14 patients with PD were chosen as background-matched subjects. We measured MCP width, ADC value of the putamen and cerebellum, and MIBG myocardial scintigraphy images. Area under curve (AUC) of receiver operating characteristic (ROC) was assessed to compare the above-mentioned methods. MCP width and ADC value of the putamen may be helpful for differentiating between MSA-P and PD relative to other methods in background-matched patients (MCP, AUC=0.95; putamen ADC, AUC=0.88; cerebellar ADC, AUC=0.70; MIBG, AUC=0.78). Similar AUCs were seen in all patients with different backgrounds. Our findings suggested that MCP width and ADC value of the putamen could be superior to ADC value of the cerebellum and MIBG uptake for differentiating between MSA-P and PD.
(キーワード): Area Under Curve / 小脳 (cerebellum) / Diagnosis, Differential / Female / Humans / Male / Middle Aged / Middle Cerebellar Peduncle / Multiple System Atrophy / パーキンソン病 (Parkinson's disease) / Putamen / ROC Curve
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jns.2016.06.061
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27538610; ● Summary page in Scopus @ Elsevier: 2-s2.0-84978114190

(DOI: 10.1016/j.jns.2016.06.061, PubMed: 27538610, Elsevier: Scopus) Mungunkhuyag Majigsuren, Takashi Abe, Teruyoshi Kageji, Kazuhito Matsuzaki, Mayumi Takeuchi, Seiji Iwamoto, Youichi Otomi, Naoto Uyama, Shinji Nagahiro and Masafumi Harada :
Comparison of brain tumor contrast-enhancement on T1-CUBE and 3D-SPGR images,
Magnetic Resonance in Medical Sciences, Vol.15, No.1, 34-40, 2016.

(要約): T1-Cube (GE HealthCare) is a relatively new 3-dimensional (3D) fast spin-echo (FSE)-based magnetic resonance (MR) imaging sequence that uses a variable flip angle to acquire gap-free volume scans. We compared the gadolinium enhancement characteristics of a heterogeneous population of brain tumors imaged by T1-Cube and then 3D fast spoiled gradient recall acquisition in steady state (3D FSPGR) 3-tesla MR imaging to identify the superior modality for specific diagnostic purposes. We examined 61 lesions from 32 patients using the 2 sequences after administration of gadopentetic acid (Gd-DTPA; 0.1 mmol/kg). Two neuroradiologists independently measured each lesion twice using a region-of-interest (ROI) method. We measured the contrast-to-noise ratio (CNR), the difference in signal intensity (SI) between the tumor and normal white matter relative to the standard deviation (SD) of the SI within the lesion, for both post-contrast 3D FSPGR and post-contrast T1-Cube images of the same tumor and compared modality-specific CNRs for all tumors and in subgroups defined by tumor size, enhancement ratio, and histopathology. The mean CNR was significantly higher on T1-Cube images than 3D FSPGR images for the total tumor population (1.85 ± 0.97 versus 1.12 ± 1.05, P < 0.01) and the histologic types, i.e., metastasis (P < 0.01) and lymphoma (P < 0.05). The difference in CNR was even larger for smaller tumors in the metastatic group (4.95 to 23.5 mm(2)) (P < 0.01). In contrast, mean CNRs did not differ between modalities for high grade glioma and meningioma. Gadolinium enhancement of brain tumors was generally higher when imaged by T1-Cube than 3D FSPGR, and T1-Cube with Gd enhancement may be superior to 3D FSPGR for detecting smaller metastatic tumors.
(キーワード): Adult / Aged / Aged, 80 and over / Astrocytoma / Brain Neoplasms / Contrast Media / Female / Gadolinium DTPA / Humans / Image Enhancement / Image Processing, Computer-Assisted / Imaging, Three-Dimensional / Lymphoma, Large B-Cell, Diffuse / 磁気共鳴映像法 (magnetic resonance imaging) / Male / Meningioma / Middle Aged / Oligodendroglioma / Signal-To-Noise Ratio / White Matter
(徳島大学機関リポジトリ): ● Metadata: 109458
(出版サイトへのリンク): ● Publication site (DOI): 10.2463/mrms.2014-0129
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26104076; ● Summary page in Scopus @ Elsevier: 2-s2.0-84954305191

(徳島大学機関リポジトリ: 109458, DOI: 10.2463/mrms.2014-0129, PubMed: 26104076, Elsevier: Scopus) Yusuke Osaki, Koji Fujita, Takashi Abe, Masafumi Harada, Yuishin Izumi and Ryuji Kaji :
Mystery Case: Parkinsonism in a diabetic uremic patient.,
Neurology, Vol.86, No.22, e225-7, 2016.

(出版サイトへのリンク): ● Publication site (DOI): 10.1212/WNL.0000000000002713
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27242385; ● Summary page in Scopus @ Elsevier: 2-s2.0-84973577883

(DOI: 10.1212/WNL.0000000000002713, PubMed: 27242385, Elsevier: Scopus) Wataru Sako, Takashi Abe, Yuishin Izumi, Masafumi Harada and Ryuji Kaji :
Fractional anisotropy in the supplementary motor area correlates with disease duration and severity of amyotrophic lateral sclerosis.,
Neurological Sciences, Vol.37, No.4, 573-577, 2016.

(要約): Amyotrophic lateral sclerosis (ALS) is progressive and fatal neurodegenerative disorder with upper and lower motor neuron signs. There are no biomarkers to track disease progression. To address this issue, we investigated regions in which fractional anisotropy (FA) values derived from diffusion weighted images correlated with both disease severity and duration in ALS patients. Fourteen patients with ALS were enrolled in this study. Voxel-based analysis revealed volume of interests (VOIs) showing significant correlation. Finally, Spearman rank correlation coefficient was assessed between FA value in each VOI and disease severity or duration. In the VOI of left supplementary motor area (SMA), FA value significantly correlated with disease severity and duration both (disease severity, rho = 0.59, p = 0.025; disease duration, rho = -0.69, p = 0.006). The present finding suggested the possibility that the abnormality in motor-related region including SMA could be a candidate for a biomarker to track disease progression.
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s10072-016-2487-z
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26809951; ● Summary page in Scopus @ Elsevier: 2-s2.0-84955300415

(DOI: 10.1007/s10072-016-2487-z, PubMed: 26809951, Elsevier: Scopus) Yoshimitsu Shimatani, Yuta Nakano, Naoko Tsuyama, Shigeo Murayama, Ryosuke Oki, Ryosuke Miyamoto, Nagahisa Murakami, Koji Fujita, Syunsuke Watanabe, Hisanori Uehara, Takashi Abe, Hiroyuki Nodera, Toshitaka Kawarai, Yuishin Izumi and Ryuji Kaji :
Extranodal NK/T-cell lymphoma, nasal type, manifesting as rapidly progressive dementia without any mass or enhancing brain lesion.,
Neuropathology, Vol.36, No.5, 456-463, 2016.

(要約): Among the many potential etiologies for rapidly progressive dementia (RPD), primary central nervous system extranodal NK/T-cell lymphoma, nasal-type (ENKL) is a rare entity. We present the first reported case of autopsy-proven RPD due to ENKL without any mass or enhancing lesion of the brain. A 54-year-old immunocompetent man presented with RPD, myoclonus and ataxia. The mini-mental state examination (MMSE) score was 22/30. His brain MRI revealed progressive brain atrophy without gadolinium enhancement or mass lesion. Five months after the initial evaluation, cognitive impairment further worsened with an MMSE score of 3/30. At the advanced stage, lumbar MRI showed swollen cauda equina with gadolinium enhancement. The number of Epstein-Barr virus (EBV) DNA in cerebrospinal fluid had gradually increased. Twelve months after onset, the patient died of respiratory failure. Pathological findings revealed that lymphoma cells had diffusely invaded the meninges, parenchyma of the brain, spinal cord and cauda equina. Cells were positive for CD3, CD56 and EBV-encoded small RNAs and negative for CD20. No evidence of malignancy was identified in the visceral organs. This report indicates that ENKL should be recognized as one of the rare causes of RPD. Early testing for EBV-DNA in cerebrospinal fluid and imaging of cauda equina would be useful diagnostic tools.
(キーワード): Brain / Brain Neoplasms / Cauda Equina / Dementia / Disease Progression / Humans / Immunocompetence / Lymphoma, Extranodal NK-T-Cell / Male / Middle Aged / Spinal Cord
(出版サイトへのリンク): ● Publication site (DOI): 10.1111/neup.12285
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26773724; ● Summary page in Scopus @ Elsevier: 2-s2.0-84989259948

(DOI: 10.1111/neup.12285, PubMed: 26773724, Elsevier: Scopus) Wataru Sako, Takashi Abe, Yuishin Izumi, Masafumi Harada and Ryuji Kaji :
The ratio of N-acetyl aspartate to glutamate correlates with disease duration of amyotrophic lateral sclerosis,
Journal of Clinical Neuroscience, Vol.27, 110-113, 2016.

(要約): Glutamate (Glu)-induced excitotoxicity has been implicated in the neuronal loss of amyotrophic lateral sclerosis. To test the hypothesis that Glu in the primary motor cortex contributes to disease severity and/or duration, the Glu level was investigated using MR spectroscopy. Seventeen patients with amyotrophic lateral sclerosis were diagnosed according to the El Escorial criteria for suspected, possible, probable or definite amyotrophic lateral sclerosis, and enrolled in this cross-sectional study. We measured metabolite concentrations, including N-acetyl aspartate (NAA), creatine, choline, inositol, Glu and glutamine, and performed partial correlation between each metabolite concentration or NAA/Glu ratio and disease severity or duration using age as a covariate. Considering our hypothesis that Glu is associated with neuronal cell death in amyotrophic lateral sclerosis, we investigated the ratio of NAA to Glu, and found a significant correlation between NAA/Glu and disease duration (r=-0.574, p=0.02). The "suspected" amyotrophic lateral sclerosis patients showed the same tendency as possible, probable and definite amyotrophic lateral sclerosis patients in regard to correlation of NAA/Glu ratio with disease duration. The other metabolites showed no significant correlation. Our findings suggested that glutamatergic neurons are less vulnerable compared to other neurons and this may be because inhibitory receptors are mainly located presynaptically, which supports the notion of Glu-induced excitotoxicity.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jocn.2015.08.044
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26765768; ● Summary page in Scopus @ Elsevier: 2-s2.0-84952673779

(DOI: 10.1016/j.jocn.2015.08.044, PubMed: 26765768, Elsevier: Scopus) Wataru Sako, Nagahisa Murakami, Yoshimichi Miyazaki, Takashi Abe, Masafumi Harada, Yuishin Izumi and Ryuji Kaji :
The effect of tremor onset on middle cerebellar peduncle of Parkinson's disease.,
Journal of the Neurological Sciences, Vol.358, No.1-2, 172-177, 2015.

(要約): The majority of studies of Parkinson's disease (PD) focused on basal ganglia initially; however, accumulating evidence suggests cerebellar involvement in pathophysiology. We aimed to investigate the effects of tremor onset on middle cerebellar peduncle (MCP) width of PD patients and of disease duration on differential diagnosis. We measured MCP width of 81 PD, 34 multiple system atrophy (MSA) and 16 normal controls, using MRI. A meta-analysis was performed including two previous and the present studies. We carried out correlation analysis between disease duration and MCP width separately in subgroup of PD with or without tremor onset. Receiver operating characteristic curves were analyzed. Our meta-analysis indicated that MCP width was significantly smaller in MSA relative to PD with homogeneous studies. There was significant correlation between disease duration and MCP width in PD without tremor onset. In contrast, there was no correlation observed in PD with tremor onset. Subclassification according to disease duration showed improved area under curve of PD vs. MSA with predominant parkinsonian features. MCP width could be a valuable tool for differential diagnosis. Our finding suggested that MCP was impaired in advanced stage of PD without tremor onset as part of the abnormality of the cerebellar system.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jns.2015.08.1531
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26341153; ● Summary page in Scopus @ Elsevier: 2-s2.0-84956834073

(DOI: 10.1016/j.jns.2015.08.1531, PubMed: 26341153, Elsevier: Scopus) Takashi Abe, Yoshifumi Mizobuchi, Kohhei Nakajima, Youichi Otomi, Saho Irahara, Yuki Obama, Mungunkhuyag Majigsuren, Delgerdalai Khashbat, Teruyoshi Kageji, Shinji Nagahiro and Masafumi Harada :
Diagnosis of brain tumors using dynamic contrast-enhanced perfusion imaging with a short acquisition time,
SpringerPlus, Vol.24, No.4, 88, 2015.

(要約): This study sought to determine the diagnostic utility of perfusion parameters derived from dynamic contrast-enhanced (DCE) perfusion MRI with a short acquisition time (approximately 3.5 min) in patients with glioma, brain metastasis, and primary CNS lymphoma (PCNSL). Twenty-six patients with 29 lesions (4 low-grade glioma, 13 high-grade glioma, 7 metastasis, and 5 PCNSL) underwent DCE-MRI in a 3 T scanner. A ROI was placed on the hotspot of each tumor in maps for volume transfer contrast K (trans) , extravascular extracellular volume V e , and fractional plasma volume V p . We analyzed differences in parameters between tumors using the Mann-Whitney U test. We calculated sensitivity and specificity using receiver operating characteristics analysis. Mean K (trans) values of LGG, HGG, metastasis and PCNSL were 0.034, 0.31, 0.38, 0.44, respectively. Mean Ve values of each tumors was 0.036, 0.57, 0.47, 0.96, and mean Vp value of each tumors was 0.070, 0.086, 0.26, 0.17, respectively. Compared with other tumor types, low-grade glioma showed lower K (trans) (P < 0.01, sensitivity = 88%, specificity = 100%) and lower V e (P < 0.01, sensitivity = 96%, specificity = 100%). PCNSL showed higher V e (P < 0.01, sensitivity = 100%, specificity = 88%), but the other perfusion parameters overlapped with those of different histology. Kinetic parameters derived from DCE-MRI with short acquisition time provide useful information for the differential diagnosis of brain tumors.
(徳島大学機関リポジトリ): ● Metadata: 109680
(出版サイトへのリンク): ● Publication site (DOI): 10.1186/s40064-015-0861-6
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25793147; ● Summary page in Scopus @ Elsevier: 2-s2.0-84924942590

(徳島大学機関リポジトリ: 109680, DOI: 10.1186/s40064-015-0861-6, PubMed: 25793147, Elsevier: Scopus) 多田恵曜, 平澤元浩, 牟礼英生, 里見淳一郎, 山本伸昭, 阿部考志, 永廣信治 :
T2強調画像で脊髄内に高信号を呈する病変圧迫骨折を伴い，両下肢の筋力低下で発症した80歳女性,
脳神経外科速報, Vol.24, No.11, 1208-1211, 2014年. Yoshiteru Tada, Junichiro Satomi, Takashi Abe, Kazuyuki Kuwayama, Shu Sogabe, Koji Fujita, Nobuaki Yamamoto, Ryuji Kaji, Masafumi Harada and Shinji Nagahiro :
Intra-arterial signal on arterial spin labeling perfusion MRI to identify the presence of acute middle cerebral artery occlusion,
Cerebrovascular Diseases, Vol.38, No.3, 191-196, 2014.

(要約): The susceptibility vessel sign on gradient echo-type-T2*-weighted imaging is a well-known marker of arterial occlusion. Stagnant flow in front of the middle cerebral artery (MCA) occlusion sites may contribute to the intra-arterial, high-intensity signal on arterial spin labeling magnetic resonance imaging (MRI), making it another potential marker of MCA occlusion. We compared the intra-arterial, high-intensity signal and susceptibility vessel sign in patients with symptomatic MCA occlusion and patients without major vessel occlusion. We identified transient ischemic attack or ischemic stroke patients with (1) 3-T MRI performed within 24 h after clinical onset including arterial spin labeling, T2*-weighted imaging, and magnetic resonance angiography (MRA) and (2) either having MCA occlusion (n = 34 patients) or without major vessel occlusion (n = 24 patients). The intra-arterial, high-intensity signal was defined as an enlarged circular or linear bright hyperintensity within the artery. The susceptibility vessel sign was defined as an enlarged spot of hypointensity within the MCA, in which the diameter of the hypointense signal within the vessel exceeded the contralateral vessel diameter. The presence or absence of the intra-arterial, high-intensity signal and susceptibility vessel sign were assessed, along with their inter-rater agreement and consistency with the presence of MCA occlusion on MRA. The intra-arterial, high-intensity signal was detectable in 30 patients (52%), and susceptibility vessel sign was observed in 17 patients (29%). The sensitivity of the intra-arterial high-intensity signal was significantly higher than that of the susceptibility vessel sign (88% vs. 50%; p < 0.05). The accuracy of the intra-arterial high-intensity signal was also higher than that of the susceptibility vessel sign (93% vs. 71%; p < 0.05). The intra-arterial high-intensity signal was situated in the proximal regions of the susceptibility vessel sign on T2*WI within the MCA. Neither the intra-arterial high-intensity signal nor the susceptibility vessel sign was observed in patients without major vessel occlusion. Inter-rater agreement was good for intra-arterial high-intensity signal detection (κ = 0.73) and moderate for susceptibility vessel sign detection (κ = 0.47). The presence or absence of the intra-arterial high-intensity signal was highly consistent with that of MCA occlusion on MRA (κ = 0.74). The intra-arterial high-intensity signal on arterial spin labeling appears to be useful to identify the presence of acute MCA occlusion and may be associated with stagnant flow in front of occlusion sites. The intra-arterial high-intensity signal may also be used to identify the occlusion site.
(キーワード): Aged / Aged, 80 and over / Cerebral Angiography / Female / Humans / Infarction, Middle Cerebral Artery / Ischemic Attack, Transient / Magnetic Resonance Angiography / 磁気共鳴映像法 (magnetic resonance imaging) / Male / Middle Aged / Middle Cerebral Artery / Sensitivity and Specificity / Stroke
(出版サイトへのリンク): ● Publication site (DOI): 10.1159/000365653
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25300901; ● Summary page in Scopus @ Elsevier: 2-s2.0-84912121647

(DOI: 10.1159/000365653, PubMed: 25300901, Elsevier: Scopus) Mungunkhuyag Majigusuren, Masafumi Harada, Takashi Abe, Koji Fujita, Naoko Matsui and Ryuji Kaji :
Longitudinal Monitoring with Multiple MR Techniques in a Case of Progressive Multifocal Leukoencephalopathy Associated with Multiple Myeloma,
Magnetic Resonance in Medical Sciences, Vol.13, No.1, 55-59, 2014.

(要約): Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the brain caused by the JC virus in immunocompromised patients. We report characteristic features of proton MR spectroscopy, 3-dimensional pseudo-continuous arterial spin labeling imaging, and diffusion tensor imaging in a 53-year-old patient with PML. The utility of multi-modal magnetic resonance techniques for longitudinal monitoring was indicated by their reevaluation over time and consideration of their relation to prognosis.
(キーワード): Disease Progression / Humans / Leukoencephalopathy, Progressive Multifocal / Magnetic Resonance Imaging / Male / Middle Aged / Multiple Myeloma
(出版サイトへのリンク): ● Publication site (DOI): 10.2463/mrms.2013-0037
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24492738; ● Summary page in Scopus @ Elsevier: 2-s2.0-84897898031

(DOI: 10.2463/mrms.2013-0037, PubMed: 24492738, Elsevier: Scopus) Yuka Terasawa, Yusuke Osaki, Toshitaka Kawarai, Tatsurou Sugimoto, Antonio Orlacchio, Takashi Abe, Yuishin Izumi and Ryuji Kaji :
Increasing and persistent DWI changes in a patient with Hereditary Diffuse Leukoencephalopathy with Spheroids.,
Journal of the Neurological Sciences, 2013.

(要約): We report a case with genetically confirmed hereditary diffuse leukoencephalopathy with spheroids with distinctive MRI features. A 52-year-old woman with a family history of juvenile dementia presented with an 18-month history of progressive cognitive decline. Longitudinal magnetic resonance imaging studies of the brain revealed increasing and persistent white matter hyperintensities on diffusion-weighted images. Linear high intensity signal along axonal fibers arisen from the cerebral cortex was also shown. Finding of subcortical calcifications was noted on brain CT scan. Sequence analysis of CSF1R showed a novel missense mutation c.2467C>T (p.Ala823Val). Persistent and increasing diffusion on magnetic resonance image, presumably reflecting intramyelinic oedema in regions of neurodegeneration, is a distinctive feature observed in this case. The presence of this unique finding can be a diagnostic clue in the early stage of the disease.
(キーワード): Hereditary Diffuse Leukoencephalopathy with Spheroids (HDLS) / Diffusion-weighted imaging (DWI) / colony stimulating factor 1 receptor (CSF1R)
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jns.2013.08.027
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24094860; ● Search Scopus @ Elsevier (PMID): 24094860; ● Search Scopus @ Elsevier (DOI): 10.1016/j.jns.2013.08.027

(DOI: 10.1016/j.jns.2013.08.027, PubMed: 24094860)

MISC

Yuki Matsumoto, Masafumi Harada, Yuki Kanazawa, Takashi Abe, Maki Ohtomo, Taniguchi Yo, Ono Masaharu and Bito Yoshitaka :
Calculation of Concentration of Contrast Media, Relaxivity, Extracellular pH and Oxygen Extraction Fraction for Brain Tumor Characterization,
Proceedings of the 28th Annual Meeting of ISMRM, No.4983, 2020. Yuki Matsumoto, Masafumi Harada, Yuki Kanazawa, Takashi Abe, Maki Ohtomo, Taniguchi Yo, Ono Masaharu and Bito Yoshitaka :
Calculation of molar relaxivity and concentration map of Gd-DTPA map using quantitative parameter map before and after injection for brain metastasis,
Proceedings of the 27th Annual Meeting of ISMRM, No.4983, 2019. Yuki Matsumoto, Masafumi Harada, Yuki Kanazawa, Takashi Abe, Maki Ohtomo and Miyoshi Mitsuharu :
Chemical exchange saturation transfer imaging depending on several neurodegenerative diseases at 3T,
Proceedings of the 27th Annual Meeting of ISMRM, No.2795, 2019. 中島公平, 松下展久, 溝渕佳史, 阿部考志, 影治照喜, 永廣信治 :
高齢者における頭蓋内多発性病変,
脳神経外科速報, Vol.25, No.3, 268-272, 2015年. 藤田浩司, 大崎裕亮, 阿部考志, 原田雅史, 梶隆兒 :
T2*強調画像における脳実質・脳表の低信号,
脳神経外科速報, Vol.25, No.1, 38-42, 2015年. 多田恵曜, 平澤元浩, 牟礼英生, 里見淳一郎, 山本信昭, 阿部考志 :
T2強調画像で脊髄内に高信号を呈する病変,
脳神経外科速報, Vol.24, No.11, 1194-1197, 2014年. 宮﨑由道, 松井尚子, 藤田浩司, 阿部考志, 高橋利幸, 原田雅史 :
脳室周囲および延髄背側の病変,
脳神経外科速報, Vol.24, No.10, 1100-1105, 2014年. 大崎裕亮, 藤田浩司, 瓦井俊孝, 寺澤由佳, 乾俊夫, 阿部考志 :
年単位で持続する大脳白質の拡散強調画像高信号,
脳神経外科速報, Vol.24, No.9, 980-986, 2014年. 平井聡, 桑山一行, 多田恵曜, 里見淳一郎, 阿部考志, 藤田浩司 :
T2*強調画像における脳静脈洞，皮質静脈の低信号病変,
脳神経外科速報, Vol.24, No.7, 700-704, 2014年. 沖良祐, 藤田浩司, 庄野健児, 里見淳一郎, 阿部考志 :
大脳白質・線条体に相次いで出現する拡散低下,
脳神経外科速報, Vol.24, No.5, 528-531, 2014年. 阿部考志, 原田雅史 :
脳腫瘍 –Permeability imaging を用いた脳腫瘍の画像診断,
月刊インナービジョン, Vol.29, No.5, 40-43, 2014年. 大崎裕亮, 藤田浩司, 阿部考志, 梶隆兒 :
大脳基底核における左右対称の浮腫性病変,
脳神経外科速報, Vol.24, No.4, 400-403, 2014年. Toshio Inui, Toshitaka Kawarai, Koji Fujita, Kazuyuki Kawamura, Takao Mitsui, Antonio Orlacchio, Masaki Kamada, Takashi Abe, Yuishin Izumi and Ryuji Kaji :
A new CSF1R mutation presenting with an extensive white matter lesion mimicking primary progressive multiple sclerosis.,
Journal of the Neurological Sciences, 2013.

(要約): HDLS (Hereditary Diffuse Leukodystrophy with Spheroids) is a hereditary leukodystrophy whose main clinical manifestations include parkinsonism, spasticity, and ataxia. Genetic defects in the colony-stimulating factor 1 receptor (CSF1R) gene have been reported in many HDLS cases. The present report describes a new missense mutation Arg777Gln involving exon 18 of the CSF1R gene in a sporadic patient presenting with tumor-like lesions mimicking primary progressive multiple sclerosis. The patient was initially diagnosed with a progressive variant of multiple sclerosis and received inadequate treatments. Although most HDLS cases have a positive family history, this disease should also be suspected in sporadic patients showing unusual white matter lesions at MRI.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jns.2013.08.020
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24034409; ● Search Scopus @ Elsevier (PMID): 24034409; ● Search Scopus @ Elsevier (DOI): 10.1016/j.jns.2013.08.020

(DOI: 10.1016/j.jns.2013.08.020, PubMed: 24034409)

総説・解説

阿部考志, 原田雅史 :
脳梗塞超急性期の画像診断 MRI,
日獨医報, 2017年. 宮﨑由道, 松井尚子, 藤田浩司, 阿部考志, 高橋利幸, 原田雅史, 梶龍兒 :
見逃し危険!MRIで迫る中枢神経疾患の画像診断(第8回) 脳室周囲および延髄背側の病変心因性障害と考えられていた39歳女性,
脳神経外科速報, Vol.24, No.10, 1094-1099, 2014年.

(要約): <Key Points>(1)視神経炎や脊髄炎を呈し，脳室周囲や延髄背側の病変，3椎体以上の長い脊髄病変を見たときはNMO spectrum disorderを疑い，抗AQP4抗体を検査する．(2)NMO spectrum disorderの急性期はステロイドパルスや血漿交換を行い，再発予防はプレドニゾロンが第一選択である．(著者抄録)
(キーワード): Prednisolone(治療的利用) 延髄(画像診断) 血漿交換 *MRI *視神経脊髄炎(画像診断,薬物療法,治療) 鑑別診断多発性硬化症脳室(画像診断) 心因性疾患ヒト成人(19~44) 女

講演・発表

(出版サイトへのリンク): ● Publication site (DOI): 10.26044/ecr2020/C-08767
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.26044/ecr2020/C-08767

(DOI: 10.26044/ecr2020/C-08767) Wada Yugo, Yuki Kanazawa, Masafumi Harada, Naoki Maeda, Yuki Matsumoto, Takashi Abe, Hiroaki Hayashi, Miyoshi Mitsuharu and Carl Michel :
Multi-components analysis of brain using ultrashort echo time magnetic resonance imaging,
European Congress of Radiology, Wien, Mar. 2020.

(出版サイトへのリンク): ● Publication site (DOI): 10.26044/ecr2020/C-08766
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.26044/ecr2020/C-08766

(DOI: 10.26044/ecr2020/C-08766) Yuki Matsumoto, Masafumi Harada, Yuki Kanazawa, Takashi Abe, Taniguchi Yo, Ono Masaharu and Bito Yoshitaka :
How does synthetic MRI depict biological information? A step toward planning for deep brain stimulation (DBS),
European Congress of Radiology, Wien, Mar. 2020. Yuki Matsumoto, Masafumi Harada, Yuki Kanazawa, Takashi Abe, Maki Ohtomo, Taniguchi Yo, Ono Masaharu and Bito Yoshitaka :
Simultaneously Calculation of Concentration of Contrast Media, Relaxivity, and Oxygen Extraction Fraction using Quantitative Parameter Mapping,
RSNA2019 (Radiological Society of North America), Chicago, Dec. 2019. Yuki Matsumoto, Masafumi Harada, Yuki Kanazawa, Takashi Abe, Maki Ohtomo, Taniguchi Yo, Ono Masaharu and Bito Yoshitaka :
Calculation of molar relaxivity and concentration map of Gd-DTPA map using quantitative parameter map before and after injection for brain metastasis,
ISMRM 27th Annual Meeting, Montreal, May 2019. Yuki Matsumoto, Masafumi Harada, Yuki Kanazawa, Takashi Abe, Maki Ohtomo and Miyoshi Mitsuharu :
Chemical exchange saturation transfer imaging depending on several neurodegenerative diseases at 3T,
ISMRM 27th Annual Meeting, Montreal, May 2019. Yuki Kanazawa, Chiba Daiki, Masafumi Harada, Miyati Tosiaki, Miyoshi Mitsuharu, Hiroaki Hayashi, Yuki Matsumoto, Takashi Abe and Akihiro Haga :
Thermal sensitive pH imaging using CEST,
ISMRM 27th Annual Meeting, Montreal, May 2019. Yuki Kanazawa, Masafumi Harada, Taniguchi Yo, Hiroaki Hayashi, Takashi Abe, Maki Ohtomo, Yuki Matsumoto, Ono Masafumi, Bito Yoshitaka and Akihiro Haga :
Myelin imaging derived from quantitative parameter mapping,
ISMRM 27th Annual Meeting, Montreal, May 2019. Takashi Abe, Yuki Matsumoto, Yuki Kanazawa, Yoichi Otomi, Maki Otomo, Moriaki Yamanaka, Mihoko Kondou, Saya Matsuzaki, Ariundbold Gankhuyag, Enkhamgalan Dolgorsuren, Oyundari Gonchigsuren and Masafumi Harada :
Comparing neural networks for synthesizing FLAIR images from T1WI and T2WI,
ISMRM 27th Annual Meeting, Montreal, Apr. 2019. Wataru Sako, Takashi Abe, Shotaro Haji, Nagahisa Murakami, Yuishin Izumi, Masafumi Harada and Ryuji Kaji :
Derivation and characterization of Parkinson's disease related pattern using functional magnetic resonance imaging,
The Movement Disorder Society 21th International Congress of Parkinson's Disease and Movement Disorders, Hong Kong, Oct. 2018. Takashi Abe and N. Salamon :
A Deep Learning Approach to Synthesize FLAIR Image from T1WI and T2WI,
ISMRM-ESMRMB joint annual meeting 2018, Paris, Jun. 2018. 阿部考志 :
ディープラーニング(画像診断を中心に),
NDC月例会, ロサンゼルス, 2017年10月. Wataru Sako, Takashi Abe, Yuishin Izumi, Masafumi Harada and Ryuji Kaji :
Difference in glutamate concentration in the thalamus between Parkinsons disease and multiple system atrophy,
XX III World Congress of Neurology, Sep. 2017. Wataru Sako, Takashi Abe, Murakami Nagahisa, Miyazaki Yoshimichi, Yuishin Izumi, Masafumi Harada and Kaji Ryuji :
Imaging-based differential diagnosis between multiple system atrophy and Parkinsons disease,
he Movement Disorder Society 20th International Congress of Parkinson's Disease and Movement Disorders, Jun. 2016. Takashi Abe, M. Majigsuren, H Kabasawa, T Matsuda, Shinji Nagahiro and Masafumi Harada :
A study for high signal intensity on ASL outside of enhanced area in brain tumors using DSC perfusion imaging,
ASNR 54th Annual Meeting, Washington, D.C., May 2016. Takashi Abe, D. Khashubat, H. Kabasawa, T. Matsuda, Shinji Nagahiro and Masafumi Harada :
A study for high signal intensity on ASL outside of enhanced area in brain tumors using DCE permeability imaging,
ASNR 54th Annual Meeting, Washington, D.C., May 2016. Takashi Abe, 苛原早保, Youichi Otomi, 小濵祐樹, 山中森晶 and 岩本誠司 :
Discrepancy Between Arterial Spin Labeling Images and Contrast-Enhanced Images of Brain Tumors,
国際磁気共鳴医学会, Jun. 2015. Takashi Abe, Toshitaka Kawarai, 小濵祐樹, 苛原早保, 梶誠司 and Ryosuke Miyamoto :
Retrospective review of MRS findings in HDLS and in elderly asymptomatic carriers of a causative gene, CSF-1R: a single institution study,
Apr. 2015. Takashi Abe, Toshitaka Kawarai, Obama Y, Irahara I, Kaji Seiji, Ryosuke Miyamoto, Sakai Waka, Tsukamoto-Miyashiro Ai, Naoko Matsui, Yuishin Izumi, Ryuji Kaji and Masafumi Harada :
Retrospective review of MRI and MRS findings in hereditary diffuse leukoencephalopathy with spheroids and elderly asymptomatic carrier of causative gene, colony stimulating factor-1 receptor: a single institution study.,
ASNR 53rd Annual Meeting & The Foundation of the ASNR Symposium, Apr. 2015. Junichiro Satomi, Yoshiteru Tada, Takashi Abe, Kazuyuki Kuwayama, Ryuji Kaji, Nobuaki Yamamoto, Masafumi Harada and Shinji Nagahiro :
Intra-arterial signal on arterial spin labeling perfusion MRI can identify stagnant flow in patients with acute middle cerebral rtery occlusion,
INTERNATIONAL STROKE CONFERENCE 2015, Nashville, USA, Feb. 2015. Takashi Abe, Masafumi Harada, M Mungunkhuyag and K Delgerdalai :
Dynamic Contrast- Enhanced Perfusion Imaging Analysis for Diagnosis of Brain Tumors Using Different Measurement Method.,
American Society of Neuroradiology 52nd Annual Meeting, Montreal, Quebec, Canada, May 2014. Takashi Abe, K Delgerdalai, M Mungunkhuyag and Masafumi Harada :
A Short Acquisition Time Dynamic Contrast-Enhanced Perfusion Imaging for the Diagnosis of Brain Tumors with Fixed T1 Method and Full Automatic Detection of Vascular Input Function.,
American Society of Neuroradiology 52nd Annual Meeting, Montreal, Quebec, Canada., May 2014. 金澤裕樹, 前田直輝, 原田雅史, 谷口陽, 松元友暉, 阿部考志, 林裕晃, 伊藤公輔, 尾藤良孝, 芳賀昭弘 :
Quantitative Parameter Mapping(QPM) を用いたコンポーネント間スピン交換定数の導出,
第48回日本磁気共鳴医学会大会Web開催, 2020年9月. Yuki Matsumoto, Masafumi Harada, Yuki Kanazawa, Takashi Abe, Taniguchi Yo, Ono Masaharu and Bito Yoshitaka :
Which contrast agent is more sensitive to extracellular pH change on brain tumor ?,
JSMRM2020, Sep. 2020. 坂本優子, 阿部考志, 音見暢一, 東航平, 松崎紗弥, 三橋遼太, 大友真姫, 原田雅史, 和泉唯信 :
当院における進行性多巣性白質脳症(PML)の5症例の画像所見脳血流や代謝画像を含めて,
第79日回日本医学放射線学会総会, 2020年5月. Yuki Kinjo, Yuki Kanazawa, Masafumi Harada, Yo Taniguchi, Yuki Matsumoto, Takashi Abe, Hiroaki Hayashi, Masaharu Ono, Yoshitaka Bito and Akihiro Haga :
Spatially smoothing processing of quantitative values in voxel-based morphometry (VBM) analysis,
第76回日本放射線技術学会総会学術大会WEB開催, May 2020. Yuki Matsumoto, Masafumi Harada, Yuki Kanazawa, Takashi Abe, Taniguchi Yo, Ono Masaharu and Bito Yoshitaka :
Simultaneous Quantitative Calculation of Concentration of Contrast Agent, Relaxivity, and Extracellular pH Map,
Japanese Journal of Radiological Technology, Apr. 2020. 松田拓, 島田健司, 宮本健志, 阿部考志, 高麗雅章, 兼松康久, 髙木康志 :
T1-CUBEが有効であった頭蓋内動脈解離の2例,
日本脳神経外科学会第78回学術集会, 2019年10月. 松元友暉, 金澤裕樹, 金城祐奎, 原田雅史, 阿部考志, 兼松康久, 髙木康志 :
頸動脈狭窄の定量評価を目的とした4D-flow流体解析,
第1回 4D FLOW研究会, 2019年9月. Yuki Matsumoto, Masafumi Harada, Yuki Kanazawa, Takashi Abe, Taniguchi Yo, Ono Masaharu and Bito Yoshitaka :
Calculation of extracellular pH using quantitative parameter mapping,
JSMRM2019, Sep. 2019. Yuki Kinjo, Yuki Kanazawa, Masafumi Harada, Yo Taniguchi, Yuki Matsumoto, Takashi Abe, Hiroaki Hayashi, Masaharu Ono, Yoshitaka Bito and Akihiro Haga :
Comparison of estimation parameters of relaxation rate and susceptibility for myelin content with quantitative parameter mapping,
JSMRM2019, Sep. 2019.

(要約): To evaluate myelin content derived from QPM, we compared relaxation rate and susceptibility using simultaneously acquired imaging datasets. The relaxation rate and susceptibility derived from QPM enabled us to simultaneously and specifically evaluate structural changes and brain iron homeostasis.

金澤裕樹, 原田雅史, 谷口陽, 林裕晃, 阿部考志, 大友真姫, 松元友暉, 小野順玄, 尾藤良孝, 芳賀昭弘 :
Quantitative Parameter Mappingを用いたミエリンMRI,
第75回日本放射線技術学会総会学術大会, 2019年4月. Yuki Matsumoto, Masafumi Harada, Yuki Kanazawa, Takashi Abe, Maki Ohtomo, Taniguchi Yo, Ono Masaharu and Bito Yoshitaka :
Calculation of molar relaxivity and concentration map of Gd-DTPA map using quantitative parameter map before and after injection for brain metastasis,
ISMRM Japanese Chapter, Dec. 2018. 大友真姫, 阿部考志, 松元友暉, 金澤裕樹, 原田雅史 :
ASL法により観察された健常ボランティアにおける脳灌流の再現性と性差の評価,
第46回日本磁気共鳴学会大会, 2018年9月. 阿部考志, 原田雅史 :
A Deep Learning Approach to Synthesize FLAIR Image from T1WI and T2WI -2nd Report-. Relationship between Synthetic Image and Different Networks,
日本磁気共鳴医学会総会, 2018年9月. Wataru Sako, Takashi Abe, Shotaro Haji, Nagahisa Murakami, Takahiro Furukawa, Yuishin Izumi, Masafumi Harada and Ryuji Kaji :
Compensatory changes in the intra-cerebellar connections in Parkinson disease and multiple system atrophy,
第41回日本神経科学大会, Jul. 2018. 佐光亘, 阿部考志, 土師正太郎, 村上永尚, 古川貴大, 和泉唯信, 原田雅史, 梶龍兒 :
Graph Theoryによるパーキンソン病・多系統萎縮症の小脳を中心としたネットワーク解析,
第59回日本神経学会学術大会, 2018年5月. Takashi Abe, H. Yokota and N. Salamon :
Improvement in Automated Detection of Brain Tumor Using Deep Learning: 2nd report,
第77回日本医学放射線学会総会, Apr. 2018. Takashi Abe, H. Yokota and N. Salamon :
A Deep Learning Approach for Automated Brain Tumor Detection using T2WI with Single Shot Multibox Detector, preliminary study,
第77回日本医学放射線学会総会, Apr. 2018. Takashi Abe :
Detection of brain tumor using convolutional deep neural network trained with deep learning, preliminary study,
第45回日本磁気共鳴医学会総会, Sep. 2017. 阿部考志 :
Deep learning を用いた神経画像診断: 脳腫瘍診断の初期経験,
第45回日本磁気共鳴医学会総会, 2017年9月. Wataru Sako, Takashi Abe, Yuishin Izumi, Naoko Matsui, Masafumi Harada and Ryuji Kaji :
The local neuronal activity associated with GABA in amyotrophic lateral sclerosis,
第40回日本神経科学大会, Jul. 2017. Takashi Abe :
Simultaneous pH- and oxygen-weighted metabolic MRI of human gliomas demonstrates intratumoral metabolic heterogeneity.,
第76回日本医学放射線学会総会, Apr. 2017. Takashi Abe :
Relationship between brain tumor cell invasion, motility, and proliferation level estimates (CIMPLE maps) and 18F-fluorodopa (FDOPA) PET in low grade gliomas.,
第76回日本医学放射線学会総会, Apr. 2017. Takashi Abe :
Hyperintensity on Arterial Spin Labeling Image outside Contrast Enhanced Area in Glioma is Related to Tumor Histology and Prognosis.,
第76回日本医学放射線学会総会, Apr. 2017. 佐光亘, 阿部考志, 原田雅史, 和泉唯信, 梶龍兒 :
筋萎縮性側索硬化症における脳機能ネットワーク独立性の消失,
第46回日本臨床神経生理学会学術大会, 2016年10月. Wataru Sako, Takashi Abe, Masafumi Harada, Yuishin Izumi and 梶龍兒 :
The effect of corticospinal fiber integrity on spontaneous brain activity in the sensorimotor cortex in amyotrophic lateral sclerosis,
第39回日本神経科学大会, Jul. 2016. 佐光亘, 阿部考志, 原田雅史, 和泉唯信, 梶龍兒 :
筋萎縮性側索硬化症における低周波帯域の安静時脳機能MRI信号変化とFA値の関係,
第57回日本神経学会学術大会, 2016年5月. 阿部考志, ハシバットデルゲルダライ, ガンボルドムングンバガナ, ガンホヤグアウリンボルド, マジグスレンムングンホーヤグ, 久岡園花 :
MRSを用いた脳腫瘍の 2ヒドロキシグルタル酸計測の初期経験,
日本医学放射線学会中国四国地方会, 2015年12月. 佐光亘, 阿部考志, 原田雅史, 和泉唯信, 梶龍兒 :
筋萎縮性側索硬化症における低周波帯域の安静時脳機能MRI信号変化,
第45回日本臨床神経生理学会学術大会, 2015年11月. 佐光亘, 村上永尚, 宮﨑由道, 阿部考志, 原田雅史, 和泉唯信, 梶龍兒 :
パーキンソン病における振戦発症の中小脳脚への影響,
第9回パーキンソン病・運動障害疾患コングレス, 2015年10月. 阿部考志, 影治照喜, 永廣信治, 椛沢浩之, 松田豪, 原田雅史 :
脳腫瘍の造影域外のASL高信号域: DSC perfusion を用いた検討,
日本磁気共鳴医学会, 2015年9月. 阿部考志, 影治照喜, 永廣信治, 椛沢浩之, 松田豪, 原田雅史 :
脳腫瘍の造影域外のASL高信号域: DCE 2-compartment model analysis を用いた検討,
日本磁気共鳴医学会, 2015年9月. 佐光亘, Murakami Nagahisa, 宮﨑由道, 阿部考志, 原田雅史, 和泉唯信, 梶龍兒 :
The effect of tremor onset on middle cerebellar peduncle of Parkinsons disease,
第38回日本神経科学大会, 2015年7月. 苛原早保, Takashi Abe, Masafumi Harada, 河野奈緒子, 川﨑幸子 and 竹治励 :
A Case of Omental Actinomycosis,
腹部放射線学会, Jun. 2015. 多田恵曜, 里見淳一郎, 曽我部周, 桑山一行, 永廣信治, 阿部考志, 原田雅史, 原田雅史, 山本伸昭 :
Arterial spin labelingの動脈内高信号は急性期中大脳動脈閉塞におけるstagnant flowを反映する,
第2回日本心血管脳卒中学会学術集会, 2015年6月. Toshitaka Kawarai, Ryosuke Miyamoto, Tamura Asako, Takashi Abe, Funakoshi Yasuhiro, Orlacchio Antonio, Oki Ryosuke, Hideo Mure, Ryoma Morigaki, Satoshi Goto, Yuishin Izumi, Naito Hiroshi, Tomimoto Hidekazu and Ryuji Kaji :
Germline mosaicism of TUBB4A mutation causes dystonia in two siblings.,
56th Annual Meeting of the Japanese Society of Neurology, May 2015. Takashi Abe, 苛原早保, 小濵祐樹, 山中森晶, Youichi Otomi and 岩本誠司 :
Differentiation of recurrence from radiation necrosis after radiation therapy with ASL and DCE permeability MR imaging with histogram analysis,
日本医学放射線学会総会, Apr. 2015. Takashi Abe, 苛原早保, 小濵祐樹, 山中森晶, Youichi Otomi and 岩本誠司 :
The measurement of 2-hyroxyglutarate by using short TE MRS in CNS neoplasms: preliminary result,
日本医学放射線学会総会, Apr. 2015. 阿部考志, 苛原早保, 小濱祐樹, 山中森晶, 音見暢一, 岩本誠司 :
MRS findings of hereditary diffuse leukoencephalopathy with spheroids,
2015年3月. 阿部考志, 山中森晶, 小濱祐樹, 苛原早保, 音見暢一, 岩本誠司 :
Hereditary diffuse leukoencephalopathy with spheroids の MRI・MRS所見,
2014年12月. Takashi Abe, Mungunkhuyag Majigsren, Khashbat Delgerdalai, Otomi Yoichi, Seiji Iwamoto and Irahara Saho :
The discrepancy between pseudocontinuous ASL and CE-MRI of primary intra-axial brain tumor,
第42回日本磁気共鳴医学会, Sep. 2014. 阿部考志, 苛原早保, 宇山直人, 小濱祐樹, 山中森晶, 原田雅史 :
Arterial spin labeling MRI において，興味深い所見を示した gliomatosis cerebri の1例,
第122回日本医学放射線学会中国・四国地方会, 2014年6月. 多田恵曜, 里見淳一郎, 曽我部周, 桑山一行, 永廣信治, 阿部考志, 原田雅史, 山本伸昭 :
中大脳動脈閉塞例におけるarterial spin labelingの動脈内高信号の検討,
第1回日本心血管脳卒中学会学術集会, 2014年6月. 阿部考志, Majigsuren Mungunkhuyag, Khashbat Delgerdalai, 影治照喜, 永廣信治, 原田雅史 :
異なるモデルによるgliomaのDCE-MRI薬物動態モデル解析とpseudo-hyperpermeability signについて,
第73回医学放射線学会総会, 2014年4月. 阿部考志, Majigsuren Mungunkhuyag, Khashbat Delgerdalai, 影治照喜, 永廣信治, 原田雅史 :
DCE-MRI 薬物動態モデル解析を用いた脳腫瘍診断の初期経験,
2014年4月. 阿部考志 :
脳卒中の画像所見,
第二回当直スキルアップセミナー, 2013年6月.

研究会・報告書: 阿部考志 :
神経画像診断カンファレンスで出てきた症例を中心に,
神経内科サマーセミナー, 2015年8月. 阿部考志 :
薬物動態モデル解析を用いた脳腫蕩の画像診断,
第2 回徳島脳神経疾患談話会, 2014年3月. 阿部考志 :
DCE-perfusion analysisにおける脳腫蕩の診断:計測法による結果の違い,
第43回日本神経放射線学会, 2014年3月. 阿部考志 :
Acute bilateral basal ganglia lesions in diabetic uremiaの一例,
第121回日本医学放射線学会中国・四国地方会, 2013年12月. 阿部考志 :
脳卒中様発作を呈し，画像所見が診断の契機となった神経核内封入体病の一例,
第121回日本医学放射線学会中国・四国地方会, 2013年12月. 阿部考志 :
neck paraganglioma の一例,
第26回頭頸部放射線研究会, 2013年10月. 阿部考志 :
急性期脳梗塞と類似した所見を呈した神経変性疾患の2症例-HDLSと核内封入体病について-,
第5回徳島・倉敷脳卒中カンファレンス, 2013年10月. 阿部考志 :
急性期脳卒中の画像診断,
脳卒中リハビリテーション看護院内認定コース, 2013年10月. 阿部考志 :
視野障害で発症した脳病変の一例(primay central nervous system angiitisの一例),
第18回中国四国神経放射線研究会, 2013年8月. 阿部考志 :
徳島大学症例(hereditary diffuse leukoencephalopathy with spheroidsの一例,
第33回神経放射線ワークショップ, 2013年6月.

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補助金・競争的資金: Deep learningを用いたFLAIR画像の合成・新手法と従来法との比較 (研究課題/領域番号: 19K17271 )
レドックス制御と神経伝達バランスに関するMRIを用いたバイオマーカーの開発 (研究課題/領域番号: 15K09926 )
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受賞: 2018年12月, バイエル国際奨励賞国際飛躍症 (日本磁気共鳴医学会)
2018年12月, 優秀ポスター賞 (ISMRM Japanese Chapter)
2020年5月, 第76回日本放射線技術学会総会学術大会座長推薦優秀研究発表 (社団法人日本放射線技術学会)
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研究者番号: 40645347

所属（現在）: 2022/4/1 : 名古屋大学, 医学部附属病院, 助教

所属（過去の研究課題 情報に基づく）*注記: 2020/4/1 : 名古屋大学, 医学部附属病院, 助教
2019/4/1 : 徳島大学, 大学院医歯薬学研究部(医学域), 助教
2016/4/1 – 2017/4/1 : 徳島大学, 大学院医歯薬学研究部(医学系), 助教
2015/4/1 : 徳島大学, 大学院医歯薬学研究部, 助教

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生物系 / 医歯薬学 / 内科系臨床医学 / 放射線科学

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